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Pathology Oncology Research: POR

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https://www.readbyqxmd.com/read/28803425/frameshift-mutations-in-repeat-sequences-of-ank3-hacd4-tcp10l-tp53bp1-mfn1-lcmt2-rnmt-trmt6-mettl8-and-mettl16-genes-in-colon-cancers
#1
Su Yeon Yeon, Yun Sol Jo, Eun Ji Choi, Min Sung Kim, Nam Jin Yoo, Sug Hyung Lee
Diminished ANK3 contributes to cell survival by inhibiting detachment-induced apoptosis. TP53BP1 that interacts with p53 and MFN1 that encodes a mitochondrial membrane protein are considered to have tumor suppressor gene (TSG) functions. HACD4 involving fatty acid synthesis and TCPL10 with transcription regulation functions are considered TSGs. Many genes involved in DNA methylations such as LCMT2, RNMT, TRMT6, METTL8 and METTL16 are often perturbed in cancer. The aim of our study was to find whether these genes were mutated in colorectal cancer (CRC)...
August 12, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28803261/advantages-in-prognosis-of-adult-patients-with-ewing-sarcoma-11-years-experiences-and-current-treatment-management
#2
Dagmar Adamkova Krakorova, Katerina Kubackova, Ladislav Dusek, Tomas Tomas, Pavel Janicek, Stepan Tucek, Jana Prausova, Igor Kiss, Iva Zambo
Ewing sarcoma (ES) is an exceptionally rare tumor in adults. Data regarding outcomes of adult patients with ES and experiences with age-adapted therapeutic strategies are very limited. The aim of this study was to evaluate prognostic factors and clinical outcome in a cohort of adult patients treated according to pediatric protocols in the Czech Republic. The records of 58 adult ES patients diagnosed between 2002 and 2013 were reviewed and factors relevant to prognosis and survival were analyzed. The median age of study cohort was 29 years (range, 18-59)...
August 12, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28795345/prognostic-implications-of-mir-302a-b-c-d-in-human-gastric-cancer
#3
Gang Ma, Qianjun Li, Weijie Dai, Xiaozhong Yang, Aiyu Sang
BACKGROUND: The microRNA (miR)-302 family consisting four members, miR-302a, miR-302b, miR-302c and miR-302d, plays an important role in diverse biological processes, and regulates many pathological changes, including cancer. However, the involvement of the miR-302 family into human gastric cancer (GC) remains unclear. The aim of this study was to investigate the expression patterns of miR-302a/b/c/d and determine their clinical significance in GC. MATERIALS AND METHODS: Expression levels of miR-302a/b/c/d in 160 pairs of human GC and matched normal mucosa tissues were detected by quantitative real-time polymerase chain reaction...
August 9, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28785968/prognosis-of-signet-ring-cell-carcinoma-of-the-colon-and-rectum-and-their-distinction-of-mucinous-adenocarcinoma-with-signet-ring-cells-a-comparative-study
#4
Luis I Pozos-Ochoa, Leonardo S Lino-Silva, Alberto M León-Takahashi, Rosa A Salcedo-Hernández
Signet ring cell carcinoma (SRCC) of the colorectum is very rare, comprising between <1% and 2.4% cases of colorectal cancer. Patients' prognoses are poor. Several case reports had described as SRCC cases that are mucinous adenocarcinomas (MAC) with signet ring cells (SRC). In order to clearly delineate between MAC with SRC and SRCC, we performed a retrospective study at a national cancer referral center in which survival and clinicopathological characteristics between these two forms were compared and also SRCC were characterized by immunohistochemistry...
August 7, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28780723/vitamin-d-receptor-gene-polymorphism-association-with-susceptibility-to-early-onset-breast-cancer-in-iranian-brca1-2-mutation-carrier-and-non-carrier-patients
#5
Ahmad Shahabi, Majid Alipour, Hamid Safiri, Parsa Tavakol, Mehdi Alizadeh, S Milad Hashemi, Mahdieh Shahabi, Mohammad Halimi
Mounting evidences support that vitamin D insufficiency or deficiency is a risk factor of breast cancer. Vitamin D receptor (VDR) is expressed in more than 36 cell types in different organs as in cancerous cells. Numerous allelic variants of VDR gene have been identified in human populations. Association of FokI (rs2228570) and BsmI (rs1544410) single nucleotide polymorphisms (SNPs) in VDR gene with the risk of breast cancer have been investigated in several studies, however, the published data are still inconsistent...
August 6, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28766250/exploring-the-histogenesis-and-diagnostic-strategy-using-immunoassay-and-rt-pcr-in-alveolar-soft-part-sarcoma
#6
Xinxin Ju, Kunming Sun, Ruixue Liu, Shugang Li, Gulinaer Abulajiang, Hong Zou, Jiaojiao Lan, Yan Ren, Jinfang Jiang, Weihua Liang, Lijuan Pang, Feng Li
Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma, but it's easily misdiagnosed in rare locations. The derivation of ASPS is still uncertain, therefore we conducted this study to explore the histogenesis of ASPS by analyzing stem cell markers (ALDH1, CD29, CD133 and Nestin). Protein TFE3 and fusion gene ASPS-TFE3 were tested in paraffin to explore diagnostic strategy and molecular pathological features. In this study, nine cases of ASPS were immunostained with stem cell surface markers (ALDH1, CD29, CD133 and Nestin) and protein TFE3...
August 1, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28756506/high-and-low-molecular-weight-oat-beta-glucan-reveals-antitumor-activity-in-human-epithelial-lung-cancer
#7
Anna Choromanska, Julita Kulbacka, Joanna Harasym, Remigiusz Oledzki, Anna Szewczyk, Jolanta Saczko
Beta-glucans are widely used in treatment, cosmetics, and the food industry. Glucans play a significant role in activation of the immune and antioxidant system and inhibiting tumor proliferation. In the current study the antitumor activities of new high and low molecular weight beta-glucan derived from oats were investigated in two human lung cancer cell line (A549, H69AR) and normal keratinocytes (HaCaT). The effect of high and low molecular weight beta-glucan from oat was evaluated by cellular viability assessment, lipid peroxidation and manganese superoxide dismutase evaluation and cytoskeleton visualisation...
July 29, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28755093/her2-and-top2a-gene-amplification-and-protein-expression-in-upper-tract-urothelial-carcinomas
#8
Klaus Aumayr, Tobias Klatte, Barbara Neudert, Peter Birner, Shahrokh Shariat, Manuela Schmidinger, Martin Susani, Andrea Haitel
HER2, a potential target for therapy, has been described to be amplified in urothelial carcinomas. As the topoisomerase II alpha (TOP2A) gene is located close to the HER2 gene on chromosome 17q12-q21, it is frequently either co-amplified or deleted with HER2 amplification. The purpose of this study was to assess the impact HER2 and TOP2A gene amplification as well as protein expression on outcomes of upper tract urothelial carcinoma (UTUC). HER2 and TOP2A gene amplification and protein expression were assessed in 81 patients with radical nephroureterectomy for UTUC...
July 28, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28752222/high-grade-t1-papillary-urothelial-bladder-cancer-shows-prominent-peritumoral-retraction-clefting
#9
Tihana Džombeta, Božo Krušlin
Differentiation of noninvasive from invasive papillary urothelial carcinoma can be challenging due to inability of proper orientation and thermal damage of transurethrally obtained material. The aim of this study was to analyze the presence and extent of peritumoral retractions in pT1 compared to pTa papillary urothelial carcinoma. Since peritumoral retractions may result from altered expression profiles of extracellular matrix proteins, we additionally analyzed the expression of matrix metalloproteinase 2 (MMP-2) and interleukin 8 (IL-8) in these tumors...
July 27, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28744693/vegfa-involves-in-the-use-of-fluvastatin-and-zoledronate-against-breast-cancer
#10
Haihong Pu, Qingyuan Zhang, Chunbo Zhao, Lei Shi, Yan Wang, Jingxuan Wang, Minghui Zhang
Our study aimed to identify key genes involved in the use of fluvastatin and zoledronate against breast cancer, as well as to investigate the roles of vascular endothelial growth factor A (VEGFA) in the malignant behaviors of breast cancer cells. The expression data GSE33552 was downloaded from Gene Expression Omnibus database, including mocked-, fluvastatin- and zoledronate-treated MDA-MB-231 cells. Differentially expressed genes (DEGs) were identified in fluvastatin- and zoledronate-treated cells using limma package, respectively...
July 25, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28695322/the-tumor-entity-denominated-clear-cell-papillary-renal-cell-carcinoma-according-to-the-who-2016-new-classification-have-the-clinical-characters-of-a-renal-cell-adenoma-as-does-harbor-a-benign-outcome
#11
REVIEW
Francesco Massari, Chiara Ciccarese, Ondrej Hes, Michal Michal, Anna Caliò, Michelangelo Fiorentino, Francesca Giunchi, Alessandro D'Amuri, Francesca Sanguedolce, Roberto Sabbatini, Annalisa Guida, Andrea Ardizzoni, Camillo Porta, Roberto Iacovelli, Giampaolo Tortora, Luca Cima, Cinzia Ortega, Alberto Lapini, Guido Martignoni, Matteo Brunelli
The new WHO 2016 classification of renal neoplasia encounters the new entity called "clear cell papillary renal cell carcinoma" (ccpRCC). The ccpRCC has been long included as a subtype of clear cell RCC histotype and it actually ranges from 2 to 9% in different routinely available cohort of renal carcinomas. Of important note, ccpRCC does not show any recurrences or metastases or lymph-node invasion and the outcome is always good. We reviewed twenty-four publications with available follow-up for patients (no...
July 10, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28695321/angiogenesis-and-lymphangiogenesis-in-the-adrenocortical-tumors
#12
Sofia S Pereira, Madalena M Costa, Susana G Guerreiro, Mariana P Monteiro, Duarte Pignatelli
Adrenocortical tumors (ACT) are common adrenal tumors. The majority of ACTs are non-functioning and benign, while adrenocortical carcinomas (ACC) are rare, usually very aggressive and often metastasized when first diagnosed. Our aim was to assess whether blood and lymph vessel density within ACTs correlate with the malignancy character or tumor functionality. For that, the microvascular distribution was evaluated by immunohistochemistry staining with D2-40 antibody, for lymph vessels and CD-31 antibody, for blood vessels, in ACCs (n = 15), adenomas with Cushing syndrome (n = 9) and non-functioning adenomas (n = 10)...
July 10, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28685219/clinicopathological-significance-of-micropapillary-pattern-in-lung-adenocarcinoma
#13
Jung-Soo Pyo, Joo Heon Kim
The aim of this study was to elucidate the clinicopathological characteristics of the micropapillary (MP) subtype and its correlation with survival in lung adenocarcinoma. We investigated the clinicopathological characteristics, including the incidence, sex, smoking history, tumor size, lymph node metastasis, lymphovascular invasion, distant metastasis, genetic alteration, and prognosis in lung adenocarcinoma with the MP pattern through a meta-analysis. From 48 eligible studies, 19,502 lung adenocarcinomas were included...
July 6, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28685218/influence-of-cyp2c19-genotypes-on-the-occurrence-of-adverse-drug-reactions-of-voriconazole-among-hematological-patients-after-allo-hsct
#14
Beata Sienkiewicz, Donata Urbaniak-Kujda, Jarosław Dybko, Andrzej Dryś, Magdalena Hurkacz, Tomasz Wróbel, Anna Wiela-Hojeńska
The aim of this study was to determine the influence of different CYP2C19 genotypes on selected liver function parameters, and ADR occurrence during VCZ prophylaxis in adult patients after allo-HSCT (allogeneic hematopoietic stem cell transplantation). CYP2C19 mutations were determined in a cohort of 30 adults using PCR-RFLP methods established by Sim et al. and Goldstein and Blaisdell. The patients' protocol included biometrical and biochemical data, information on the underlying disease, chemotherapy, molds infections occurring during VCZ treatment, adverse drug reactions typical for the use of voriconazole, and probable drug - drug interactions...
July 6, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28681123/estrogen-receptor-%C3%AE-as-a-prognostic-marker-of-tumor-progression-in-colorectal-cancer-with-familial-adenomatous-polyposis-and-sporadic-polyps
#15
Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Maria Dirlei Begnami, Fábio de Oliveira Ferreira, Wilson Toshihiko Nakagawa, Ranyell Matheus Sobreira Batista Spencer, Tiago Santoro Bezerra, Philip Edward Boggiss, Ademar Lopes
The incidence of colorectal cancer (CRC) is lower in women than in men, and sex steroids can be considered contributing factors because oral contraception usage and estrogen replacement therapy are associated with decreased risk. Conversely, colorectal polyp development in familial adenomatous polyposis (FAP) begins during puberty. The objectives were to evaluate the relationship between the expression of these hormone receptors and adenoma-carcinoma progression, CRC stage and overall survival. We studied 120 A...
July 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28681122/lewis-x-antigen-is-associated-to-head-and-neck-squamous-cell-carcinoma-survival
#16
Martín E Rabassa, Adrian Pereyra, Liliana Pereyra, Amada Segal-Eiras, Martín C Abba, Maria V Croce
Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with poor prognosis without appropriate prognostic markers. Previous research shows that Lewis antigens have been involved in carcinoma dissemination and patients´ survival. Fucosyl and sialyltransferases are the enzymes implicated in the Lewis antigens synthesis. The purpose of this study was to evaluate the prognostic utility of Lewis antigens in HNSCC. We conducted a prospective research including histological samples from 79 patients with primary HNSCC...
July 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28669081/distribution-of-vascular-patterns-in-different-subtypes-of-renal-cell-carcinoma-a-morphometric-study-in-two-distinct-types-of-blood-vessels
#17
Amparo Ruiz-Saurí, V García-Bustos, E Granero, S Cuesta, M A Sales, V Marcos, A Llombart-Bosch
To analyze the presence of mature and immature vessels as a prognostic factor in patients with renal cell carcinoma and propose a classification of renal cancer tumor blood vessels according to morphometric parameters. Tissue samples were obtained from 121 renal cell carcinoma patients who underwent radical nephrectomy. Staining with CD31 and CD34 was used to differentiate between immature (CD31+) and mature (CD34+) blood vessels. We quantified the microvascular density, microvascular area and different morphometric parameters: maximum diameter, minimum diameter, major axis, minor axis, perimeter, radius ratio and roundness...
July 1, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28669080/identification-of-potential-gene-network-associated-with-hcv-related-hepatocellular-carcinoma-using-microarray-analysis
#18
Yang Cheng, Jian Ping, Jianjie Chen
In order to identify potential specific gene networks of Hepatitis C virus (HCV) related hepatocellular carcinoma (HCC), weighted gene co-expression network analysis (WGCNA) was performed, which may provide an insight into the potential mechanism of the HCC development. HCV-related HCC and normal sample data were downloaded from GEO, T test of limma package was used to screen different expression genes (DEGs); KEGG pathway was used to analyze related biochemical pathways, and WGCNA was used to construct clustering trees and screen hub genes in the HCC-specific modules...
July 1, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28669079/immunohistochemical-analysis-of-foxp3-cd4-cd8-cell-infiltrates-and-pd-l1-in-oral-squamous-cell-carcinoma
#19
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
The immunoexpression of the PD-L1 and the number of immune infiltrating cells have been shown to be a significant prognostic factors in various human cancers. Immunohistochemical method was used to examine the immunoexpression of PD-L1 and number of Foxp3+, CD4+, CD8+ cells in 78 cases of oral squamous cell carcinomas (OSCCs): with better prognosis - OSCCBP (n = 37), and with poorer prognosis - OSCCPP (n = 41), and 18 cases of normal mucosa as a control. The immunoexpression of PD-L1 and the mean number of Foxp3+ cells was significantly increased in OSCCPP group in comparison to OSCCBP and control groups...
July 1, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28667494/single-nucleotide-polymorphisms-of-the-msh2-and-mlh1-genes-potential-molecular-markers-for-susceptibility-to-the-development-of-basal-cell-carcinoma-in-the-brazilian-population
#20
Poliane da Silva Calixto, Otávio Sérgio Lopes, Mayara Dos Santos Maia, Sylvia Satomi Takeno Herrero, Carlos Alberto Longui, Cynthia Germoglio Farias Melo, Ivan Rodrigues de Carvalho Filho, Leonardo Ferreira Soares, Arnaldo Correia de Medeiros, Plínio Delatorre, André Salim Khayat, Rommel Rodriguez Burbano, Eleonidas Moura Lima
Basal cell carcinoma - BCC is considered a multifactorial neoplasm involving genetic, epigenetic and environmental factors. Where UVB radiation is considered the main physical agent involved in BCC carcinogenesis. The Brazil and state of Paraíba are exposed to high levels of UVB rays. The mismatch repair - MMR is important DNA repair mechanisms to maintain replication fidelity. Therefore, single nucleotide polymorphisms (SNPs) in genes encoding proteins involved in MMR may be potential molecular markers of susceptibility to BCC...
June 30, 2017: Pathology Oncology Research: POR
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