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Pathology Oncology Research: POR

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https://www.readbyqxmd.com/read/28224356/trio-gene-encoding-trio-rho-guanine-nucleotide-exchange-factor-harbors-frameshift-mutations-of-in-gastric-and-colorectal-cancers
#1
LETTER
Eun Ji Choi, Min Sung Kim, Nam Jin Yoo, Sug Hyung Lee
No abstract text is available yet for this article.
February 21, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28224355/erratum-to-genetic-screening-in-pheochromocytoma-paraganglioma
#2
Peihua Liu, Xiongbing Zu, Longfei Liu
No abstract text is available yet for this article.
February 21, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28191604/dual-immunohistochemical-detection-of-mitoses-in-melanoma
#3
LETTER
Thomas M Soike, John C Maize, Jonathan S Ralston, Benjamin Hayes, Julie Swick
No abstract text is available yet for this article.
February 12, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28190163/tribute-to-prof-george-klein
#4
LETTER
Ladislas Robert
No abstract text is available yet for this article.
February 12, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28188432/correlations-of-igf-1r-and-cox-2-expressions-with-ras-and-braf-genetic-mutations-clinicopathological-features-and-prognosis-of-colorectal-cancer-patients
#5
Mei Jin, Zi-Wen Long, Jing Yang, Xiang Lin
This case-control study aims to investigate the correlations of insulin-like growth factor receptor 1 (IGF-1R) and cyclooxygenase 2 (COX-2) expressions with Ras and BRAF genetic mutations, clinicopathological features and prognosis of colorectal cancer (CRC) patients. A total of 213 CRC patients (case group) and 200 healthy individuals (control group) were selected from our hospital. Ras (K-Ras/N-Ras) and BRAF genetic mutations were detected by direct sequencing. The positive expression rates of IGF-IR and COX-2 in CRC and normal tissues were detected using immunohistochemistry...
February 10, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28185164/in-vivo-uptake-of-rare-earth-metals-by-triple-negative-breast-cancer-cells
#6
Luca Roncati, Antonietta Morena Gatti, Giuseppe Barbolini, Francesco Piscioli, Teresa Pusiol, Antonio Maiorana
Rare earth metals (REM) are a group of 17 chemical elements in the periodic table, namely scandium (Sc), yttrium (Y) and the lanthanides. In relation to atomic volume and geological behavior, the lanthanides are further subdivided into light, medium and heavy REM. They find many applications in the technological field; however, their impact on the human health is still conflicting and, for many aspects, unknown. During a research program carried on 113 cases of female breast cancer, immunohistochemically categorized in Her2-positive (29 cases), Her2-negative (57 cases) and triple negative (27 cases), aimed to evaluate the role of environmental particulate in carcinogenesis by elemental microanalysis, for the first time in literature we have detected a REM uptake, in detail europium (Eu), dysprosium (Dy) and praseodymium (Pr), inside the neoplastic cells belonging to a single triple negative breast cancer...
February 9, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28176259/low-frequent-mutation-of-arhgap35-a-candidate-tumor-suppressor-gene-in-gastric-and-colorectal-cancers
#7
LETTER
Eun Ji Choi, Min Sung Kim, Sang Yong Song, Nam Jin Yoo, Sug Hyung Lee
No abstract text is available yet for this article.
February 7, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28161812/tumor-grade-versus-expression-of-invasion-related-molecules-in-astrocytoma
#8
József Virga, László Bognár, Tibor Hortobágyi, Gábor Zahuczky, Éva Csősz, Gergő Kalló, Judit Tóth, Gábor Hutóczki, Judit Reményi-Puskár, László Steiner, Almos Klekner
Peritumoral infiltration is characteristic of astrocytomas even in low-grade tumors. Tumor cells migrate to neighbouring tissue and cause recurrence. The extracellular matrix (ECM) plays a role in tumor invasion; expression levels of its components' have been linked to tumor invasion. This study determines the mRNA and protein expression of 20 invasion-related ECM components by examining non-tumor brain; grade I-II-III astrocytoma and glioblastoma samples. Expression levels were measured by QRT-PCR and mass-spectroscopy...
February 4, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28160197/much-more-than-trousseau-syndrome-the-broad-spectrum-of-the-pancreatic-paraneoplastic-syndromes
#9
REVIEW
Attila Zalatnai, Eszter Perjési, Eszter Galambos
When 150 years ago Armand Trousseau proposed that some thrombotic events might be the first sign of concealed visceral malignancies, these findings seemed to be just of anecdotal interest. Since then, however, we have learned that adenocarcinomas, including pancreatic cancers could be associated with a wide spectrum of paraneoplastic syndromes. They may precede the detection of the tumor, may occur simultaneously or may develop during its progression. Due to various hematologic, endocrine, cutaneous, articular, neuromuscular, renal or even psychiatric syndromes, their correct interpretation is intriguing, and because their early signs are not necessarily recognized first by oncologists, the paraneoplastic syndromes pose a diagnostic challenge...
February 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28144881/association-of-caa-and-tatc-insertion-deletion-genetic-polymorphisms-in-rtn4-3-utr-with-hepatocellular-carcinoma-risk
#10
NaNa Wang, KeYu Chen, Jia Xu, Fang Yuan, HongYu Li, FengMei Deng, LuShun Zhang
Evidence from recent researchers suggested that RTN4 is a multifunctional gene, including tumor suppression, apoptosis, vascular remodeling, and inhibition of axonal regeneration. The CAA and TATC insertion/deletion polymorphisms (CAA/TATC polymorphisms) of RTN4 3″-untranslated regions (UTRs) have been linked to cervical squamous cell carcinoma (CSCC), uterine leiomyomas (UL) and non-small cell lung cancer (NSCLC). However, the association between these two polymorphisms sites with Hepatocellular Carcinoma (HCC) risk was not carry out before...
January 31, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28138922/tumor-preventive-efficacy-of-emodin-in-7-12-dimethylbenz-a-anthracene-induced-oral-carcinogenesis-a-histopathological-and-biochemical-approach
#11
Asokan Manimaran, Shanmugam Manoharan
The aim of the present study is to focus the chemopreventive potential of Emodin during 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Tumors were developed in the buccal pouches of golden Syrian hamsters by painting with 0.5% DMBA thrice a week for 14 weeks. The status of lipid peroxidation, antioxidants and detoxification agents were utilized as biochemical endpoints and the expression pattern of apoptotic proteins was employed as molecular endpoints in addition to the histopathological studies, to substantiate the anticancer potential of Emodin...
January 31, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28138921/absolute-lymphocyte-count-alc-after-induction-treatment-predicts-survival-of-pediatric-patients-with-acute-lymphoblastic-leukemia
#12
Tamas Farkas, Judit Müller, Daniel J Erdelyi, Monika Csoka, Gabor T Kovacs
Absolute Lymphocyte Count (ALC) has been recently established as a prognostic factor of survival in pediatric Acute Lymphoblastic Leukemia (ALL). A retrospective analysis of 132 patients treated according the BFM - ALLIC 2002 protocol was performed in a single institution. A possible association between ALC values and Overall Survival (OS) or Event-Free Survival (EFS) was evaluated at multiple time points during induction chemotherapy. ALC higher than 350 cells/μL measured on the 33th day of induction was associated with better Overall- and Event-Free Survival in both Kaplan-Meier (OS 88...
January 30, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28132116/exosomes-derived-from-irradiated-esophageal-carcinoma-infiltrating-t-cells-promote-metastasis-by-inducing-the-epithelial-mesenchymal-transition-in-esophageal-cancer-cells
#13
Hua Min, Xiangdong Sun, Xi Yang, Hongcheng Zhu, Jia Liu, Yuandong Wang, Guangzong Chen, Xinchen Sun
Exosomes are nanovesicles derived from tumor and normal cells that are detectable in human biological fluids, such as plasma, and cell culture supernatants. The function of exosome secretion from "normal" cells is unclear. Although numerous studies have investigated exosomes derived from hematopoietic cells, little is known regarding exosomes fromT cells, even though these cells play significant roles in innate and acquired immunity. A CCK-8 assay was used to examine the ability of exosomes to inhibit TE13 cell proliferation...
January 28, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28116562/normothermic-and-hyperthermic-intraperitoneal-chemoperfusions-with-cisplatin-to-treat-advanced-ovarian-cancer-in-experimental-settings
#14
LETTER
G S Kireeva, V G Bespalov, O A Belyaeva, K Y Senchik, A N Stukov, G I Gafton, K D Guseynov, A M Belyaev
No abstract text is available yet for this article.
January 23, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28116561/prognostic-impact-of-different-histological-types-on-gastric-adenocarcinoma-a-surveillance-epidemiology-and-end-results-database-analysis
#15
Kaitai Liu, Juefeng Wan, Yanping Bei, Xue Chen, Miaozhen Lu
The clinicopathological characteristics and prognosis of gastric mucinous adenocarcinoma (MAC) and signet ring cell carcinoma (SRC) are still controversial. We designed our study to evaluate the clinicopathologic features and prognosis of MAC, SRC and ordinary gastric adenocarcinoma (OGAC) by analyzing the Surveillance, Epidemiology, and End Results (SEER)-registered database. The 5-year overall survival (OS) of patients with SRC was significantly lower than that of patients with MAC (P = 0.001) and OGAC (P < 0...
January 23, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28116560/platelets-micro-particles-and-elastase-a-review-with-extrapolation-to-the-mechanism-of-generation-and-bio-pathology-of-platelet-fragments
#16
LETTER
L Robert, J Labat-Robert
No abstract text is available yet for this article.
January 23, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28110439/combination-of-interleukin-1-polymorphism-and-helicobacter-pylori-infection-an-increased-risk-of-gastric-cancer-in-pakistani-population
#17
Yasir Raza, Adnan Khan, Asif Iqbal Khan, Saeed Khan, Shakeel Akhter, Muhammad Mubarak, Ayaz Ahmed, Shahana Urooj Kazmi
Helicobacter pylori is one of the major risk factors involved in the development ofgastritis and gastric cancer (GC). H. pylori infection leads to increased production of pro-inflammatory cytokines by the host. Carriage of specific polymorphisms in cytokine genes may be associated with host susceptibility to the development of GC. We investigated the role of host genetic factors including polymorphisms of IL-1B and IL-1RN in correlation with gastritis and GC in H. pylori infected Pakistani population. A total of 230 gastritis cases and 100 GC cases were genotyped for IL 1B-511 and IL-1RN penta-allelic variable number of tandem repeats (VNTRs)...
January 21, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28108880/unusual-signal-patterns-of-break-apart-fish-probes-used-in-the-diagnosis-of-soft-tissue-sarcomas
#18
Gergő Papp, Dóra Mihály, Zoltán Sápi
Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Altogether 301 soft tissue sarcomas with confirmed molecular tests using break-apart probes were assessed to reveal the frequency and type of unusual signal pattern. Among 89 synovial sarcoma (SS18) 11%, 12 alveolar rhabdomyosarcoma (FOXO1) 50%, 53 myxoid liposarcoma (DDIT3) 7...
January 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28102463/marked-differences-of-haplotype-tagging-snp-distribution-linkage-and-haplotype-profile-of-apoa5-gene-in-roma-population-samples
#19
Katalin Sumegi, Balazs Duga, Bela I Melegh, Zsolt Banfai, Erzsebet Kovesdi, Anita Maasz, Bela Melegh
Roma people are underprivileged, neglected population worldwide, with severe healthcare problems. They have significantly increased prevalence of cardiovascular morbidity, presumably related to their poor social status, alcohol consumption and smoking habits. Assuming that genetic background also plays a role in their susceptibility for cardiovascular diseases, we hypothesized that APOA5 gene polymorphisms, an important role-player in lipid metabolism and in the development of metabolic syndrome and cardio/cerebrovascular events, may also be involved...
January 19, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28101801/identification-of-changes-in-the-human-papilloma-virus-16-hpv16-genome-during-early-dissemination-of-cervical-cancer-cells-may-complement-histological-diagnosis-of-lymph-node-metastasis
#20
Anirban Roychowdhury, Sudip Samadder, Md Saimul Islam, Kalyansree Chaudhury, Anup Roy, Dipanwita Banerjee, Ranajit Mandal, Partha S Basu, Susanta Roychoudhury, Chinmay Kumar Panda
Cancer of the uterine cervix (CACX) is one of the most common carcinoma affecting women worldwide. During treatment, histologically lymph node (LN) metastasis and presence of HPV DNA in blood plasma act as a major prognostic factor. Despite the lack of apparent LN involvement, some early-invasive CACX patients have shown recurrences and poor survival. This is suggestive of undetected early dissemination of cancer cells characterized by presence of HPV DNA in histologically non-metastatic LNs which finally progresses into histologically visible metastasis...
January 19, 2017: Pathology Oncology Research: POR
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