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Acta Medica (Hradec Králové)

Dimitrios Patoulias
Sodium glucose co-transporter type 2 inhibitors (SGLT-2 inhibitors) are a class of antidiabetics, recently approved for the treatment of patients with T2DM. They feature cardioprotective and renoprotective action, while they exert beneficial effects on metabolic parameters. Non-alcoholic fatty liver disease (NAFLD) is a frequent co-morbidity in diabetic patients. Its prevalence reaches up to 70%. Since there is no specific treatment approved for NAFLD, both experimental and clinical studies have been recently conducted highlighting the efficacy and safety of SGLT-2 inhibitors mainly in animal models and secondarily in patients with T2DM and NAFLD...
2017: Acta Medica (Hradec Králové)
Antigony Mitselou, Stamatis S Papadatos, Savvina Tsoultsidou, Kleio Fragkouli, Michail Mitsis, Theodoros Vougiouklakis, Vasiliki Galani
A 59-year-old male patient was hospitalized in the Internal Medicine Department for investigation of hepatic metastases from an unknown primary neoplasm. During the hospitalization the patient died from acute myocardial infarction. The autopsy revealed a 8.2 kilograms (kg) liver that was diffusely infiltrated by whitish metastatic masses. No other tumor was detected, apart from a 2.5 centimeters (cm) pulmonary nodule next to the right intermediate bronchus that was histologically compatible with small cell lung cancer (SCLC)...
2017: Acta Medica (Hradec Králové)
Ioannis Asproudis, Paraskevas Zafeiropoulos, Andreas Katsanos, Christos Kolettis
We present the case of a female patient who grinded a ferrous sulfate tablet and placed it at the conjunctival fornix of her left eye. She rapidly developed severe ocular siderosis, with profoundly decreased visual acuity, corneal opacities, cataract, retinal degeneration and ultimately phthisis bulbi. To our knowledge, this is the first report on the consequences of application of an iron tablet on the conjunctiva.
2017: Acta Medica (Hradec Králové)
Ioannis Aidonis, Nikolaos Lazaridis, Maria Piagkou, Nikolaos Anastasopoulos, Konstantinos Natsis
Laryngocele (LC) is an uncommon clinical entity, occasionally associated with fatal complications. If its neck becomes obstructed, mucous accumulates and then a laryngeal mucocele (LMC) is formed. Reports of LMCs are rare in the literature. A fluid-filled combined LMC in a 48 year-old Greek construction worker with presenting symptoms of cervical swelling and dysphonia is described. The male patient was surgically treated via an external approach. A LC rarely becomes symptomatic and infection unusually occurs...
2017: Acta Medica (Hradec Králové)
Filip Gabalec, Martin Šimkovič, Alžběta Zavřelová, Petra Kašparová, Paula Morávková, Marcela Kopáčová, Václav Masopust, Pavel Žák, Jan Čáp, Jakub Radocha
Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the diagnosis and treatment of LCH as well as successful treatment with cladribine chemotherapy and allogeneic stem cell transplantation.
2017: Acta Medica (Hradec Králové)
Ayhan Aşkın, Ece Güvendi, Ayten Özkan, Ersin Çağrı Şimşek, Uğur Kocabaş, Aliye Tosun
OBJECTIVE: It is aimed to determine the prevalence of fibromyalgia syndrome (FMS) and its correlations with arrhythmia in patients with palpitations. MATERIAL AND METHODS: Sixty-two patients who underwent electrophysiological study (EPS) due to palpitation complaints in Cardiology department and 40 healthy controls were included in the study. The precise diagnosis of arrhythmia was established using EPS. All participants were screened for FMS using American College of Rheumatology 2010 Fibromyalgia diagnostic criteria...
2017: Acta Medica (Hradec Králové)
Jiří Kassa, Jan Korábečný
AIM: The influence of the dose on the ability of promising newly prepared reversible inhibitor of acetylcholinesterase (6-chlorotacrine) to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was evaluated. METHODS: The evaluation of the effect of pharmacological pretreatment is based on the identification of changes of soman-induced toxicity that was evaluated by the assessment of its LD50 value and its 95% confidence limit using probit-logarithmical analysis of death occurring within 24 hrs after administration of soman...
2017: Acta Medica (Hradec Králové)
Evangelos Diamantis, Paraskevi Farmaki, Spyridon Savvanis, Georgios Athanasiadis, Theodoros Troupis, Christos Damaskos
The double innervation of the thyroid comes from the sympathetic and parasympathetic nervous system. Injury rates during surgery are at 30% but can be minimized by upwardly preparing the thyroid vessels at the level of thyroid capsule. Several factors have been accused of increasing the risk of injury including age and tumor size. Our aim was to investigate of there is indeed any possible correlations between these factors and a possible increase in injury rates following thyroidectomy. Seven studies were included in the meta-analysis...
2017: Acta Medica (Hradec Králové)
Dimitrios Patoulias, Maria Kalogirou, Ioannis Patoulias
Amyand's hernia is defined as an inguinal hernia, containing the appendix within the hernia sac. Incidence of this rare condition rises up to 1% (0.19-1.7%) of all inguinal hernia cases. Inflammation of the appendix within the inguinal sac is even rarer, as it corresponds to 0.1% (0.07-0.13%) of all Amyand's hernia cases. After a comprehensive review of the limited relevant literature, we aim through this review study to describe the pathophysiology of inflammation of the appendix - contained in the hernia sac - and present the latest data about the diagnostic approach and surgical treatment of Amyand's hernia...
2017: Acta Medica (Hradec Králové)
Andro Gliha, Andrija Car, Stjepan Višnjić, Bozidar Zupancic, Karmen Kondza, Ivan Petracic
The umbilical cord hernia is the rarest form of abdominal wall malformations, anatomically completely different from gastroschisis and omphalocele. It occurs due to the permanent physiological evisceration of abdominal organs into umbilical celom and persistence of a patent umbilical ring. The umbilical cord hernia is often mistaken for omphalocele and called "small omphalocele". Here we present a case of a female newborn with umbilical cord hernia treated in our Hospital. After preoperative examinations surgery was done on the second day of life...
2017: Acta Medica (Hradec Králové)
Ozkan Durmaz, Ali Karadag, Fusun Demircivi Ozer, Mahmut Camlar, Erik H Middlebrooks, Baran Bozkurt, Mehmet Senoglu
We present a rare case of a patient with a persistent headache for many years found to have an intracranial nail present for nearly 65 years. The nail was found entering approximately 1 cm from the midline on the left side, passing below the superior sagittal sinus, with the tip 1.5 mm right of the frontal horn of the lateral ventricle. Treatment strategies designed to optimize outcome for intracranial foreign bodies and possible complications are discussed in this report. We also discuss the decision for surgical intervention for foreign bodies and the relevance of position of the foreign body...
2017: Acta Medica (Hradec Králové)
Zenon Pogorelić, Miro Jukić, Veselin Škrabić, Ivana Mrklić, Vesna Fridl Vidas, Ivo Jurić, Dubravko Furlan
INTRODUCTION: Testicular torsion is a urological emergency. If not recognized in time, this condition may result in ischaemic injury and loss of testis. Simultaneous bilateral neonatal testicular torsion is extremely rare and is usually misdiagnosed. CASE REPORT: We report a case of a male newborn, who presented with bilateral scrotal swelling and redness of the scrotum. Doppler ultrasound supported the diagnosis of bilateral testicular torsion, with an absent blood flow signal on the right side and a weak signal on the left side...
2017: Acta Medica (Hradec Králové)
Suresh Anand, Fathima Rejula, Joseph V G Sam, Ramakrishnan Christaline, Mali G Nair, Shiji Dinakaran
PURPOSE: This double blind randomized clinical trial was conducted with the purpose of evaluating the effects of Nano-hydroxyapatite toothpaste as compared to 8% Arginine containing toothpaste in the management of Dentin hypersensitivity (DH). METHOD AND MATERIALS: Patients (30 in each group) suffering from DH and eliciting a VAS score higher than 2 in air blast and tactile test were randomly allocated (block randomization) into either a group 1 (arginine toothpaste) or group 2 (nHA toothpaste)...
2017: Acta Medica (Hradec Králové)
Paula Morávková, Darina Kohoutová, Jaroslava Vávrová, Jan Bureš
INTRODUCTION: The aim of our study was to assess association of serum S100A4 protein with ulcerative colitis (UC) and Crohn's disease (CD). METHODS: Study included 118 subjects: 93 patients with CD, 16 with UC and 9 controls. In CD group, 20/93 patients had B1 phenotype, 19/93 B2, 20/93 B3 and 34/93 B2 + B3. L1 involvement was present in 15/93, L2 in 14/93 and L3 in 64/93 patients. Serum S100A4 concentration was investigated in peripheral venous blood samples by means of ELISA...
2017: Acta Medica (Hradec Králové)
Yannis Pappas, Jitka Všetečková, Shoba Poduval, Pei Ching Tseng, Josip Car
BACKGROUND AND OBJECTIVES: CVD is an important global healthcare issue; it is the leading cause of global mortality, with an increasing incidence identified in both developed and developing countries. It is also an extremely costly disease for healthcare systems unless managed effectively. In this review we aimed to: - Assess the effect of computer-assisted versus oral-and-written history taking on the quality of collected information for the prevention and management of CVD. - Assess the effect of computer-assisted versus oral-and-written history taking on the prevention and management of CVD...
2017: Acta Medica (Hradec Králové)
Alexander A Bukhvostov, Anton S Dvornikov, Kirill V Ermakov, Pavel B Kurapov, Dmitry A Kuznetsov
Human retinoblastoma cells were proven to possess some very unusual DNApolβ species. Being 23.5 kDa monomers, which itself is not common for the DNApolβ superfamily members, these chromatin associated proteins manifests most of the DNApolβ-specifc functional peculiarities making them legitimate targets for DNA repair cytostatic inhibitors. Particularly, these tumor specific enzymes were found to be very sensitive to 25Mg2+-, 43Ca2+- and 67Zn2+-promoted magnetic isotope effects (MIE) caused a marked DNA sequence growth limitation as well as a formation of the size-invalid, i...
2017: Acta Medica (Hradec Králové)
Ali Karadag, Burak Kinali, Omer Ugur, Ismail Oran, Erik H Middlebrooks, Mehmet Senoglu
Internal carotid artery (ICA) pseudoaneurysm is a rare complication of endoscopic endonasal surgery occurring in 0.4-1.1% of cases. Pseudoaneurysms can subsequently result in other complications, such as subarachnoid hemorrhage, epistaxis, and caroticocavernous fistula with resultant death or permanent neurologic deficit. In this case, we illustrate endovascular treatment with a flow-diverting stent for an ICA pseudoaneurysm after endoscopic endonasal surgery for a pituitary adenoma in a 56-year-old male. Surgery was complicated by excessive intraoperative bleeding and emergent CT angiography confirmed an iatrogenic pseudoaneurysm on the anteromedial surface of the ICA...
2017: Acta Medica (Hradec Králové)
Sylvie Dusilová Sulková, Jiří Horáček, Eva Vykoukalová, Roman Šafránek, Alena Malá, Vladimír Palička
We present a case of severe calciphylaxis in both thighs and calves in a patient with end-stage renal disease and advanced secondary hyperparathyroidism with successful outcome after modified therapeutic approach. The cause of calciphylaxis is multifactorial. In our case, not only severe hyperparathyroidism and mediocalcinosis, but also medication (warfarin, calcium and active vitamin D) was involved. Because the initial conservative therapy was not successful, we indicated parathyroidectomy. However, we were not able to localize parathyroid glands and we contraindicated bilateral neck exploration due to the patient's critical status...
2017: Acta Medica (Hradec Králové)
Francisco José Fernández-Fernández, Eugenia Ameneiros-Lago, Cintia Tuñas-Gesto, Inmaculada Gómez-Buela
To date, there are no sufficient data to make firm recommendations on the treatment of patients with severe thrombocytopenia who require antiplatelet therapy after experiencing acute coronary syndrome. Therefore, we think that it is important to communicate the experience with individual cases. We report the case of a patient who presented with pericardial effusion causing cardiac tamponade. He had thrombocytopenia associated with myelodysplastic syndrome, and ten weeks before this admission, percutaneous transluminal coronary angioplasty with implantation of drug-eluting stents was performed for non-ST-segment elevation acute coronary syndrome...
2017: Acta Medica (Hradec Králové)
Dimitrios Patoulias, Maria Kalogirou, Thomas Feidantsis, Ignatios Kallergis, Ioannis Patoulias
Esophageal hiatal hernia is defined as the prolapse of one or more intra-abdominal organs through the esophageal hiatus. Four types are identified: type Ι or sliding hiatal hernia, type II or paraesophageal hernia (PEH), type III or mixed hernia and type IV. Congenital type II esophageal hiatal hernia is caused by a remaining gap after the formation of pleuroperitoneal membrane. We present a case of a six years old boy admitted to our department, appearing with asymptomatic anemia, who was incidentally diagnosed with Type II esophageal hiatal hernia...
2017: Acta Medica (Hradec Králové)
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