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Acta Medica (Hradec Králové)

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https://www.readbyqxmd.com/read/28976878/retinoblastoma-magnetic-isotope-effects-might-make-a-difference-in-the-current-anti-cancer-research-strategy
#1
Alexander A Bukhvostov, Anton S Dvornikov, Kirill V Ermakov, Pavel B Kurapov, Dmitry A Kuznetsov
Human retinoblastoma cells were proven to possess some very unusual DNApolβ species. Being 23.5 kDa monomers, which itself is not common for the DNApolβ superfamily members, these chromatin associated proteins manifests most of the DNApolβ-specifc functional peculiarities making them legitimate targets for DNA repair cytostatic inhibitors. Particularly, these tumor specific enzymes were found to be very sensitive to 25Mg2+-, 43Ca2+- and 67Zn2+-promoted magnetic isotope effects (MIE) caused a marked DNA sequence growth limitation as well as a formation of the size-invalid, i...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28976877/a-case-of-pseudoaneurysm-of-the-internal-carotid-artery-following-endoscopic-endonasal-pituitary-surgery-endovascular-treatment-with-flow-diverting-stent-implantation
#2
Ali Karadag, Burak Kinali, Omer Ugur, Ismail Oran, Erik H Middlebrooks, Mehmet Senoglu
Internal carotid artery (ICA) pseudoaneurysm is a rare complication of endoscopic endonasal surgery occurring in 0.4-1.1% of cases. Pseudoaneurysms can subsequently result in other complications, such as subarachnoid hemorrhage, epistaxis, and caroticocavernous fistula with resultant death or permanent neurologic deficit. In this case, we illustrate endovascular treatment with a flow-diverting stent for an ICA pseudoaneurysm after endoscopic endonasal surgery for a pituitary adenoma in a 56-year-old male. Surgery was complicated by excessive intraoperative bleeding and emergent CT angiography confirmed an iatrogenic pseudoaneurysm on the anteromedial surface of the ICA...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28976876/parathyroidectomy-in-hyperparathyroidism-associated-calciphylaxis-in-end-stage-renal-disease-should-be-prompt-and-radical-a-case-report-with-two-original-therapeutic-modifications-and-successful-outcome
#3
Sylvie Dusilová Sulková, Jiří Horáček, Eva Vykoukalová, Roman Šafránek, Alena Malá, Vladimír Palička
We present a case of severe calciphylaxis in both thighs and calves in a patient with end-stage renal disease and advanced secondary hyperparathyroidism with successful outcome after modified therapeutic approach. The cause of calciphylaxis is multifactorial. In our case, not only severe hyperparathyroidism and mediocalcinosis, but also medication (warfarin, calcium and active vitamin D) was involved. Because the initial conservative therapy was not successful, we indicated parathyroidectomy. However, we were not able to localize parathyroid glands and we contraindicated bilateral neck exploration due to the patient's critical status...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28976875/antiplatelet-therapy-in-a-patient-with-coronary-artery-disease-and-myelodysplastic-syndrome-with-thrombocytopenia
#4
Francisco José Fernández-Fernández, Eugenia Ameneiros-Lago, Cintia Tuñas-Gesto, Inmaculada Gómez-Buela
To date, there are no sufficient data to make firm recommendations on the treatment of patients with severe thrombocytopenia who require antiplatelet therapy after experiencing acute coronary syndrome. Therefore, we think that it is important to communicate the experience with individual cases. We report the case of a patient who presented with pericardial effusion causing cardiac tamponade. He had thrombocytopenia associated with myelodysplastic syndrome, and ten weeks before this admission, percutaneous transluminal coronary angioplasty with implantation of drug-eluting stents was performed for non-ST-segment elevation acute coronary syndrome...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28976874/paraesophageal-hernia-as-a-cause-of-chronic-asymptomatic-anemia-in-a-6-years-old-boy-case-report-and-review-of-the-literature
#5
Dimitrios Patoulias, Maria Kalogirou, Thomas Feidantsis, Ignatios Kallergis, Ioannis Patoulias
Esophageal hiatal hernia is defined as the prolapse of one or more intra-abdominal organs through the esophageal hiatus. Four types are identified: type Ι or sliding hiatal hernia, type II or paraesophageal hernia (PEH), type III or mixed hernia and type IV. Congenital type II esophageal hiatal hernia is caused by a remaining gap after the formation of pleuroperitoneal membrane. We present a case of a six years old boy admitted to our department, appearing with asymptomatic anemia, who was incidentally diagnosed with Type II esophageal hiatal hernia...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28976873/inflammatory-biomarkers-and-liver-histopathology-in-non-uremic-and-uremic-chronic-hepatitis-c-patients
#6
Bengu Tatar, Sukran Kose, Emel Pala, Erhan Tatar
BACKGROUND: The aim of this study is to investigate the association between hepatic activity index (HAI) and fibrosis score (FS) with inflammation biomarkers in non-uremic and uremic hepatitis C positive patients. METHODS: Fifty chronic hepatitis C (cHepC) positive patients, having a liver biopsy were included in this study. Liver biopsies were scored according to modified ISHAC scoring system. 25 healthy controls of similar age and gender were also enrolled as control group...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28976872/comparison-of-non-gated-vs-ecg-gated-ct-angiography-of-fontan-circulation-in-patients-with-implanted-stents-in-pulmonary-branches
#7
Marek Kardoš, Juraj Mikuláš, Ivan Vulev, Jozef Mašura
BACKGROUND: Motion artifacts may degrade CT examination of Fontan pathway and hinder accurate diagnosis of in-stent restenosis. PURPOSE: We retrospectively compared ECG-gated multi-detector computed tomography (CT) with non-ECG-gated CT in order to demonstrate whether or not one of the methods should be preferred. METHOD: The study included 13 patients with surgically reconstructed Fontan pathway. A total of 16 CT examinations were performed between February 2010 and November 2015...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28976871/the-terrorist-attacks-and-the-human-live-birth-sex-ratio-a-systematic-review-and-meta-analysis
#8
Gwinyai Masukume, Sinéad M O'Neill, Ali S Khashan, Louise C Kenny, Victor Grech
AIM: The live birth sex ratio is defined as male/total births (M/F). Terrorist attacks have been associated with a transient decline in M/F 3-5 months later with an excess of male losses in ongoing pregnancies. The early 21st century is replete with religious/politically instigated attacks. This study estimated the pooled effect size between exposure to attacks and M/F. Registration number CRD42016041220. METHODS: PubMed and Scopus were searched for ecological studies that evaluated the relationship between terrorist attacks from 1/1/2000 to 16/6/2016 and M/F...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28591553/familial-adenomatous-polyposis-registry-in-czech-republic-history-present-and-future
#9
Jiří Cyrany
No abstract text is available yet for this article.
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28591552/aberrant-cutaneous-nerve-loops-in-the-axilla
#10
Vishwajit Ravindra Deshmukh, Harshita Bhardwaj, Feroz Khan, Tony George Jacob
During routine dissection classes, conducted for first year undergraduate medical students, we encountered a rare anatomical variation in relation to the intercostobrachial nerve (ICBN). The ICBN represents the lateral undivided cutaneous branch of second intercostal nerve. In this case, the ICBN formed nerve loops with branches of the lateral cutaneous branch of the third intercostal nerve. These loops eventually gave branches that probably supplied the floor of the axilla and proximal arm. Nowadays, this ICBN is gaining clinical importance during the axillary lymph node dissections and mammary gland surgeries...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28591551/papillary-thyroid-carcinoma-analysis-of-the-central-compartment-s-lymph-nodes-metastases
#11
Ján Sojak, Marian Sičák, Adrian Kališ, Michal Slašťan
BACKGROUND: Papillary thyroid carcinoma is typical by regional lymph nodes metastases. Therefore we decided to analyse associated risk factors. OBJECTIVE: In this retrospective study we focused on the incidence of metastatic involvement of the central compartment's lymph nodes correlated with age, size of the primary tumour, infiltration of thyroid gland capsule, positive lymphangioinvasion in order to assess risk factors. METHOD: We analysed group of 156 patients with papillary carcinoma, who have undergone total thyroidectomy and bilateral elective central compartment neck dissection...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28591550/investigation-of-p120catenin-expression-in-human-basal-cell-carcinoma-of-the-skin
#12
Vladimír Bartoš, Milada Kullová
BACKGROUND: P120(ctn) is a specific membranous adhesion protein, that maintains the stability of intercellular junctions. An altered expression of p120(ctn), either reduced in the cell membrane or increase in the cytoplasm, plays a crucial role in carcinogenesis. No research has analysed the expression of p120(ctn) in basal cell carcinoma (BCC) of the skin so far. Therefore, we immunohistochemically studied p120(ctn) in a set of cutaneous BCCs in order to determine, whether there is difference in the expression pattern related to the histologic subtypes and tumor growth characteristics...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28550689/a-diagnostic-program-of-vascular-tumor-and-vascular-malformations-in-children-according-to-modern-classification
#13
Iryna Benzar
The aim of the study was to analyze the cohort of inpatient children with vascular anomalies according to the globally accepted classification introduced by the ISSVA. METHODS: The study included 205 inpatient children within the time period of the years 2010-2015. Types of vascular anomalies (VAs), age of patients, diagnostic procedures, and anatomical localization of VAs were analyzed. RESULTS: 65 patients of first year of life had vascular tumors, with prevalence of infantile hemangiomas (IHs) in 57 (87...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28467299/serum-level-of-antibodies-igg-igm-against-benzo-a-pyrene-7-8-diol-9-10-epoxide-dna-adducts-in-children-dermatologically-exposed-to-coal-tar
#14
Pavel Borský, Ctirad Andrýs, Jan Krejsek, Květoslava Hamáková, Jan Kremláček, Andrea Málková, Lenka Bartošová, Zdeněk Fiala, Vladimír Palička, Lenka Borská
Crude coal tar (CCT) contains polycyclic aromatic hydrocarbons (PAHs). Benzo[a]pyrene (BaP) is metabolized into a highly reactive metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) that is able to bind to DNA and creates BPDE-DNA adducts. Adducted DNA becomes immunogenic and induces immune response by production of antibodies against BPDE-DNA adducts (Ab-BPDE-DNA). Circulating Ab-BPDE-DNA was proposed as potential biomarker of genotoxic exposure to BaP (PAHs). Goeckerman therapy (GT) of psoriasis uses dermal application of CCT ointment (PAHs)...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28418831/the-evaluation-of-benefit-of-newly-prepared-reversible-inhibitors-of-acetylcholinesterase-and-commonly-used-pyridostigmine-as-pharmacological-pretreatment-of-soman-poisoned-mice
#15
Jiří Kassa, Jan Korábečný, Eugenie Nepovimová
AIM: The ability of four newly prepared reversible inhibitors of acetylcholinesterase (6-chlorotacrine, 7-phenoxytacrine, compounds 1 and 2) and currently used carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was evaluated. METHODS: The evaluation of the effect of pharmacological pretreatment is based on the identification of changes of soman-induced toxicity that was evaluated by the assessment of its LD50 value and its 95% confidence limit using probitlogarithmical analysis of death occurring within 24 h after administration of soman...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28399389/anthelmintic-flubendazole-and-its-potential-use-in-anticancer-therapy
#16
REVIEW
Kristýna Čáňová, Lucie Rozkydalová, Emil Rudolf
Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths. The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer agents. In this minireview flubendazole effects towards selected human malignant cells including myeloma, leukemia, neuroblastoma, breast cancer, colorectal cancer and melanoma are discussed along with basic data on its pharmacokinetics, metabolism and toxicity...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28260604/the-osteogenic-potential-of-human-nondifferentiated-and-pre-differentiated-mesenchymal-stem-cells-combined-with-an-osteoconductive-scaffold-early-stage-healing
#17
Luboš Tuček, Zuzana Kočí, Kristýna Kárová, Helena Doležalová, Jakub Suchánek
Despite the huge research into stem cells and their regenerative properties for bone healing, there are still unanswered questions including the recipient's respond to the presence of the stem cells, the fate of stem cells inside the bone defect and the possible advantage in utilizing pre-differentiated cells. To address these problems, we used human multipotent mesenchymal stromal/stem cells (MSCs), GMP Grade, in a rat model of bone formation. In a "bioreactor concept" approach seven Wistar rats were implanted with 0...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28440218/a-case-of-2-year-old-child-with-entero-enteric-fistula-following-ingestion-of-25-magnets
#18
Zenon Pogorelić, Matija Borić, Joško Markić, Miro Jukić, Leo Grandić
INTRODUCTION: Magnet ingestion usually does not cause serious complications, but in case of multiple magnet ingestion or ingestion of magnet with other metal it could cause intestinal obstruction, fistula formation or even perforation. CASE REPORT: We report case of intestinal obstruction and fistula formation following ingestion of 25 magnets in a 2-year-old girl. Intraoperatively omega shaped intestinal loop with fistula caused by two magnetic balls was found...
2016: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28440217/intraparenchymal-epididymal-cyst-iec-4-cm-in-diameter-in-a-15-year-old-male-patient-a-case-report-and-review-of-the-literature
#19
REVIEW
Dimitrios Patoulias, Maria Kalogirou, Ioannis Patoulias
Intraparenchymal epididymal cysts (IECs) are benign cystic formations of the epididymis of unknown pathogenesis, which typically appear in adolescence or adulthood. In patients older than 14 years old their prevalence is doubled. After systematic and thorough research of the current literature, we did not find another case report of intraparenchymal epididymal cyst with similar dimensions. The male patient, 15 years old, visited our outpatient department complaining of pain in the right hemiscrotum. Diagnosis of IEC was confirmed after the conduction of ultrasound examination...
2016: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28440216/transseptal-suturing-reduce-patient-anxiety-after-septoplasty-compared-to-nasal-packing
#20
Kamran Sari, Ali Irfan Gul, Yunus Kantekin, Ozgul Karaaslan, Zeliha Kapusuz Gencer
BACKGROUND: We measured postoperative anxiety in patients who underwent transseptal suturing or nasal packing after septoplasty. MATERIALS AND METHODS: Transseptal suturing was performed on Group 1 patients and nasal splints with airway were placed after septoplasty in Group 2 patients. Postoperative 48-h anxiety levels of both groups were measured using the State-Trait Anxiety Inventory (STAI) clinical assessment scale, prior to removal of nasal packing in Group 2...
2016: Acta Medica (Hradec Králové)
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