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Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society

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https://www.readbyqxmd.com/read/29991919/natural-products-chemistry-the-emerging-trends-and-prospective-goals
#1
Riaz A Khan
The role and contributions of natural products chemistry in advancements of the physical and biological sciences, its interdisciplinary domains, and emerging of new avenues by providing novel applications, constructive inputs, thrust, comprehensive understanding, broad perspective, and a new vision for future is outlined. The developmental prospects in bio-medical, health, nutrition, and other interrelated sciences along with some of the emerging trends in the subject area are also discussed as part of the current review of the basic and core developments, innovation in techniques, advances in methodology, and possible applications with their effects on the sciences in general and natural products chemistry in particular...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991918/evaluation-of-wound-healing-activity-of-henna-pomegranate-and-myrrh-herbal-ointment-blend
#2
Ehab M Elzayat, Sayed H Auda, Fars K Alanazi, Mohamed H Al-Agamy
This study assessed the wound healing potential and antimicrobial activity of henna, pomegranate and myrrh extract formulations and their blend in excision, and dead space wound models in rats in comparison to a marketed ointment (gentamycin). The natural extracts were used in ointment formulations alone or in a combination of three extracts at a total concentration of 15% w/w in medications. The percent of wound contraction in case of henna, myrrh, pomegranate, the blend and gentamycin (10 mg/kg) were 85...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991917/development-of-ternary-solid-dispersions-with-hydrophilic-polymer-and-surface-adsorbent-for-improving-dissolution-rate-of-carbamazepine
#3
Tanja Vojinović, Djordje Medarević, Edina Vranić, Zorica Potpara, Marko Krstić, Jelena Djuriš, Svetlana Ibrić
In this study solid dispersions of carbamazepine in the hydrophilic Kollidon® VA64 polymer, adsorbed onto Neusilin® UFL2 adsorption carrier have been employed to improve carbamazepine dissolution rate. In order to evaluate effects of changing in the proportions of all solid dispersion components on carbamazepine dissolution rate, D-optimal mixture experimental design was used in the formulation development. From all prepared solid dispersion formulations, significantly faster carbamazepine dissolution was observed compared to pure drug...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991916/self-medication-with-antibiotics-in-saudi-arabia
#4
Sultan Alghadeer, Khalid Aljuaydi, Salmeen Babelghaith, Abdullah Alhammad, Mohammed N Alarifi
Introduction: Despite of the global dilemma of antibiotics resistance, this issue is more worsen in developing countries or places where the antibiotics can be dispensed or purchased without prescription such as in Saudi Arabia. Most health awareness campaigns and published studies regarding the self-medication with antibiotics in Saudi Arabia are conducted within hospitals. The prevalence and reasons of self-medication with antibiotics were not well studied from community perspective in Saudi Arabia...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991915/release-studies-of-undecylenoyl-phenylalanine-from-topical-formulations
#5
Anna Olejnik, Aleksandra Glowka, Izabela Nowak
The aim of this study was to characterize the stability of new vehicles for the undecylenoyl phenylalanine that is used as skin-lightening agent in the melasma treatment. The purpose of this research was also to analyse the release kinetics of phenylalanine derivative from topical preparations through different synthetic membranes. Topical formulations such as two different macroemulsions, hydrogels (based on carbomer and hydroxyethylcellulose) and microemulsions were characterized in terms of stability by laser diffraction method...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991914/validation-of-a-score-to-identify-inpatients-at-risk-of-a-drug-related-problem-during-a-4-year-period
#6
O Ferrández, S Grau, O Urbina, S Mojal, M Riu, E Salas
Objective: Drug-related problems (DRP) produce high morbidity and mortality. It is therefore essential to identify patients at higher risk of these events. This study aimed to validate a DRP risk score in a large number of inpatients. Material and methods: Validation of a previously designed score to identify inpatients at risk of experiencing at least one DRP in a tertiary university hospital from 2010 to 2013. DRP were detected by a pharmacy warning system integrated in the electronic medical record...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991913/8-cyclopentyl-1-3-dimethylxanthine-enhances-effectiveness-of-antidepressant-in-behavioral-tests-and-modulates-redox-balance-in-the-cerebral-cortex-of-mice
#7
Mariola Herbet, Aleksandra Szopa, Anna Serefko, Sylwia Wośko, Monika Gawrońska-Grzywacz, Magdalena Izdebska, Iwona Piątkowska-Chmiel, Paulina Betiuk, Ewa Poleszak, Jarosław Dudka
The objective of our study was to investigate whether 8-cyclopentyl-1,3-dimethylxanthine (CPT), associated with the adenosine system, enhances the antidepressant efficacy of antidepressant. All experiments were carried out on Albino Swiss mice. Following drugs: CPT (3 mg/kg) and imipramine (15 mg/kg) were administered intraperitoneally ( ip ), 60 min before tests. Two behavioral tests on antidepressant capability - a forced swim test (FST) and a tail suspension test (TST) - were performed. To examine whether co-administration of CPT with antidepressants affects the redox balance, the lipid peroxidation products (LPO), glutathione (GSH), glutathione disulfide (GSSG), nicotinamide adenine dinucleotide phosphate (NADP+), and reduced nicotinamide adenine dinucleotide phosphate (NADPH) were determined in the cerebral cortex...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991912/analysis-of-antioxidative-and-antiviral-biomarkers-%C3%AE-amyrin-%C3%AE-sitosterol-lupeol-ursolic-acid-in-guiera-senegalensis-leaves-extract-by-validated-hptlc-methods
#8
Mohammad K Parvez, Perwez Alam, Ahmed H Arbab, Mohammed S Al-Dosari, Tawfeq A Alhowiriny, Saleh I Alqasoumi
Guiera senegalensis J.F. Gmel is a broad-spectrum African folk- medicinal plant, having activities against fowlpox and herpes viruses. Very recently, we have shown the anti-hepatitis B vius (HBV) potential of G. senegalensis leaves extract (GSLE). Here, we report the antioxidative and hepatoprotective efficacy of GSLE, including HPTLC quantification of four biomarkers of known antioxidative and antiviral activities. In cultured liver cells (HuH7) GSLE attenuated DCFH-induced oxidative stress and cytotoxicity...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991911/risk-factors-for-aquiring-multidrug-resistant-organisms-in-urinary-tract-infections-a-systematic-literature-review
#9
REVIEW
Justin Tenney, Nicholas Hudson, Hazar Alnifaidy, Justin Ting Cheung Li, Kathy Harriet Fung
Background: This is the first review to analyze literature identifying risk factors for a multidrug-resistant urinary tract infection (MDR UTI). Risk factors for other infections involving multidrug-resistant organisms have been evaluated in other reviews, but they do not assess urinary tract infections. The purpose of this study is to collect currently published data to determine the most commonly and consistently identified risk factors for UTIs. Material and methods: For this study, 3 independent researchers searched PubMed, Embase, and Cochrane database from 1966 to February 2016 for articles identifying risk factors for MDR UTI...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991910/evaluation-of-a-novel-oxiconazole-nitrate-formulation-the-thermosensitive-gel
#10
Alper Arslan, Cansel Kose Ozkan, Ali Korhan Sig, Eyup Dogan, Ozgur Esim, Serdar Cetinkaya, Filiz Atalay, Cetin Tas, Ayhan Savaser, Yalcin Ozkan
Superficial fungal infections caused by Candida species are common skin diseases. Therefore, this study aimed to develop a new formulation containing oxiconazole nitrate, which is an azole group derivative for antifungal treatment, as a thermosensitive gel since there has been no literature study until now. MIC value of the novel thermosensitive formulation against three Candida species was calculated and time-dependent antifungal activity analysis was performed. Viscosity, transition temperature Tsol-gel (°C) and gelation time of the thermosensitive gel formulation were also determined in the viscometer...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991909/distribution-of-cyp2b6-516g-t-pharmacogenetically-important-polymorphism-in-the-ukrainian-population
#11
Olga Filiptsova, Marina Kobets, Julia Kobets, Olga Naboka, Olga Koiro, Alexandr Ochkur, Larisa Galiy
The CYP2B6 is one of the members of the cytochrome P450 superfamily. This enzyme metabolizes a number of currently prescribed drugs and different compounds. In light of clinical significance of the CYP2B6∗6 variant of the CYP2B6 gene, the aim of this study was to investigate the distribution of one of the gene polymorphisms, namely, the 516G/T in the Ukrainian population. The study cohort consisted of 102 healthy Ukrainian adults (48 males, 54 females). Genotyping of the CYP2B6 (rs3745274) polymorphism in the study subjects was carried out using a polymerase chain reaction...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991908/antimicrobial-activity-of-the-biogenically-synthesized-core-shell-cu-pt-nanoparticles
#12
Renata Dobrucka, Jolanta Dlugaszewska
The interest in the biological synthesis of mono metal nanoparticles has been visible for years. As more attention is also given to the biological methods of synthesizing bimetallic nanoparticles, this work used the Agrimoniae herba extract in order to obtain bimetallic core-shell Cu@Pt nanoparticles. The formed core-shell Cu@Pt nanoparticles were characterized by Ultraviolet-Visible (UV-vis), Fourier Transform-Infrared (FT-IR), Scanning electron microscopy (SEM), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM) measurements...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991907/efficacy-of-metformin-in-the-management-of-periodontitis-a-systematic-review-and-meta-analysis
#13
REVIEW
Shariq Najeeb, Muhammad Sohail Zafar, Zohaib Khurshid, Sana Zohaib, Sreenath Arekunnath Madathil, Maria Mali, Khalid Almas
Periodontitis is characterized by inflammation of the periodontium and leads to loss of teeth if untreated. Although a number of surgical and pharmacological options are available for the management of periodontitis, it still affects a large proportion of population. Recently, metformin (MF), an oral hypoglycemic, has been used to treat periodontitis. The aim of this review is to systematically evaluate the efficacy of MF in the treatment of periodontitis. An electronic search was carried out using the keywords 'metformin', 'periodontal' and 'periodontitis' via the PubMed/Medline, ISI Web of Science and Google Scholar databases for relevant articles published from 1949 to 2016...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991906/pharmacy-students-perceptions-towards-online-learning-in-a-saudi-pharmacy-school
#14
Dalia Almaghaslah, Mohammed Ghazwani, Abdurahman Alsayari, Arwa Khaled
Objectives: The aim of the study was to evaluate previous exposure to online learning and preference for learning through pre-recorded online lectures with or without live active learning among pharmacy students in their fifth year. Methods: An anonymous online survey was self-administered to fifth-year students enrolled on the Graduation Research Project Course. Results: The response rate was 100%. Ninety-seven percent of students had previous experience with at least one online course during their pharmacy undergraduate curriculum; 76% of the courses were science courses...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991905/effect-of-educational-intervention-on-healthcare-providers-knowledge-and-perception-towards-pharmacovigilance-a-tertiary-teaching-hospital-experience
#15
Rana Abu Farha, Khawla Abu Hammour, Mai Rizik, Rand Aljanabi, Lina Alsakran
Objective: Based on the theory on planned behavior, perception or attitude is found to be a well-established predictor of healthcare providers' intentions to perform different behaviors. Also, improving knowledge was proposed to affect their practice as well. In Jordan, many studies have been conducted to evaluate healthcare providers' knowledge and perception towards pharmacovigilance but no intervention or training was provided. Thus, the aim of this study was to evaluate the impact of an educational workshop on the knowledge and perception of healthcare providers towards pharmacovigilance in a Jordanian tertiary teaching hospital...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29991904/cell-free-preparations-of-probiotics-exerted-antibacterial-and-antibiofilm-activities-against-multidrug-resistant-e-coli
#16
Ahmed G Abdelhamid, Aliaa Esaam, Mahmoud M Hazaa
The sharp increase in antibiotic resistance imposes a global threat to human health and the discovery of effective antimicrobial alternatives is needed. The use of probiotics to combat bacterial pathogens has gained a rising interest. Pathogenic Escherichia coli is causative of multiple clinical syndromes such as diarrheal diseases, meningitis and urinary tract infections. In this work, we evaluated the efficacy of probiotics to control multidrug-resistant E. coli and reduce their ability to form biofilms. Six E...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29989035/characterization-of-polysaccharides-and-their-antioxidant-properties-from-plumula-nelumbinis
#17
Yueping Jiang, Wen Zi, Zhifang Pei, Shao Liu
Two novel polysaccharides, Plumula nelumbinis (P. nelumbinis) polysaccharide I (LNP I) and P. nelumbinis polysaccharide II (LNP II), were extracted and purified from P. nelumbinis , and a sulfated polysaccharide, P. nelumbinis polysaccharide III (LNP III), with a substitution degree of 0.62 was prepared from LNPI. The structures of the LNPs were preliminarily characterized using high performance size exclusion chromatography (HPSEC), gas chromatography-mass spectrometry (GC-MS), Fourier transformed infrared spectrometry (FT-IR), and nuclear magnetic resonance (NMR) spectrometry...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29989025/a-computerized-exposure-system-for-animal-models-to-optimize-nicotine-delivery-into-the-brain-through-inhalation-of-electronic-cigarette-vapors-or-cigarette-smoke
#18
REVIEW
Fawaz Alasmari, Laura E Crotty Alexander, Christopher A Drummond, Youssef Sari
Pre-clinical studies investigated the effects of chronic exposure to nicotine on lungs, kidneys and brains using animal models. Most of these studies delivered nicotine into the circulatory and central nervous systems (CNS) through intraperitoneal injection or oral consumption methods. Few studies used inhalation machine system for nicotine delivery into brains in rodents to mimic human exposure to cigarettes. However, finding a more accurate and clinically relevant method of nicotine delivery is critical. A computerized inhalation machine has been designed (SciReq) and is currently employed in several institutions...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29989016/current-status-and-future-prospects-of-pharmaco-epidemiology-and-post-marketing-surveillance-in-saudi-arabia-a-review-of-literature
#19
REVIEW
Ashraf El-Metwally
Background: Pharmacoepidemiology is the concept used for evaluating the impact of drugs among a large number of people in the post-marketing phase . The use of this concept makes it increasingly necessary to detect the recurrence of drug-related anomalies that mostly occur through health care professionals or patients themselves. Pharmacoepidemiology is important since it helps to provide the right balance of benefits versus risks of the drug products while remaining an excellent tool to prepare the risk/benefit balance profile...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29989011/inhibition-of-cytochrome-p450-enzymes-by-thymoquinone-in-human-liver-microsomes
#20
Ahmed A Albassam, Abdul Ahad, Abdullah Alsultan, Fahad I Al-Jenoobi
The aim of the present study was to investigate the potential effect of thymoquinone (TQ) on the metabolic activity of four major drug metabolizing enzymes in human liver microsomes, namely cytochrome P450 (CYP) 1A2, CYP2C9, CYP2D6 and CYP3A4. The inhibition of CYP enzymatic activities by TQ was evaluated by incubating typical substrates (phenacetin for CYP1A2, tolbutamide for CYP2C9, dextromethorphan for CYP2D6, and testosterone for CYP3A4) with human liver microsomes and NADPH in the absence or presence of TQ (1, 10 and 100 µM)...
July 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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