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Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society

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https://www.readbyqxmd.com/read/29556137/a-novel-release-kinetics-evaluation-of-chinese-compound-medicine-application-of-the-xcelligence-rtca-system-to-determine-the-release-characteristics-of-sedum-sarmentosum-compound-sustained-release-pellets
#1
Guojun Yan, Wei Sun, Yanfang Pei, Zhaogang Yang, Xiaobing Wang, Yuan Sun, Shangtian Yang, Jinhuo Pan
Purpose : To establish a novel release kinetics evaluation method of Chinese compound medicine (Sedum Sarmentosum compound) with xCELLigence Real-Time Cell-based Assay (RTCA) system. Methods : Cell lines sensitive to Sedum Sarmentosum compound are screened, and cell index-time (CI-T) graphs and cell index release kinetics models are established based on the cell index (CI) monitored. The methodological studies of precision and repeatability were processed by the cell monitors system. The release profiles of the sustained-release Sedum Sarmentosum compound were determined...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556136/secondary-metabolites-isolated-from-pinus-roxburghii-and-interpretation-of-their-cannabinoid-and-opioid-binding-properties-by-virtual-screening-and-in-vitro-studies
#2
Rola M Labib, Radhakrishnan Srivedavyasasri, Fadia S Youssef, Samir A Ross
Pinus roxburghii is highly popular as a potent analgesic and anti-inflammatory agent; however its exact mechanism of action was not fully elucidated. We aimed to interpret the analgesic and anti-inflammatory activity of the total ethanol extract of Pinus roxburghii bark (PRE) and its isolated compounds by both in silico molecular modelling and in-vitro cannabinoid and opioid binding activities evaluation for the first time. Comprehensive phytochemical investigation of PRE resulted in the isolation of sixteen compounds that were fully elucidated using1 H NMR and13 C NMR...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556135/-in-vitro-characterization-of-arylhydrazones-of-active-methylene-derivatives
#3
Suresh Palanivel, Anastasia Zhurina, Phuong Doan, Jerome G Chandraseelan, Vinoth Kumar Megraj Khandelwal, Fedor I Zubkov, Kamran T Mahmudov, Armando J L Pombeiro, Olli Yli-Harja, Meenakshisundaram Kandhavelu
Arylhydrazones of active methylene compounds (AHAMCs) are potent chemotherapy agents for the cancer treatment. AHAMCs enhance the apoptotic cell death and antiproliferation properties in cancer cells. In this study, a series of AHAMCs, 13 compounds, was assayed for cytotoxicity, apoptosis, externalization of phosphatidylserine, heterogeneity and cellular calcium level changes. The in vitro cytotoxicity study against HEK293T cells suggests that AHAMCs have significant cytotoxic effect over the concentrations...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556134/investigation-of-nepetolide-as-a-novel-lead-compound-antioxidant-antimicrobial-cytotoxic-anticancer-anti-inflammatory-analgesic-activities-and-molecular-docking-evaluation
#4
Tanzeel Ur Rehman, Arif-Ullah Khan, Azar Abbas, Javid Hussain, Farman Ullah Khan, Kimberly Stieglitz, Shamsher Ali
In the present study, we describe various pharmacological effects and computational analysis of nepetolide, a tricyclic clerodane-type diterpene, isolated from Nepeta suavis . Nepetolide concentration-dependently (1.0-1000 µg/mL) exhibited 1,1-diphenyl,2-picrylhydrazyl free radical scavenging activity with maximum effect of 87.01 ± 1.85%, indicating its antioxidant potential, as shown by standard drug, ascorbic acid. It was moderately active against bacterial strain of Staphylococcus aureus . In brine shrimp's lethality model, nepetolide potently showed cytotoxic effect, with LC50 value of 8...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556133/quality-of-life-and-complementary-and-alternative-medicine-use-among-women-with-breast-cancer
#5
Hadeel Albabtain, Monira Alwhaibi, Khalid Alburaikan, Yousif Asiri
Background: Complementary and Alternative Medication (CAM) is commonly used among women with breast cancer to improve their quality of life (QoL). However, few studies examine the prevalence of CAM and its' relation to the patients' QoL among women with breast cancer. Methods: A cross-sectional study was conducted among 95 women with breast cancer at a tertiary hospital in Saudi Arabia. The outcome measure of interest was the QoL. The correlation was used to assess the association between CAM use and QoL...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556132/release-and-permeation-profiles-of-spray-dried-chitosan-microparticles-containing-caffeic-acid
#6
Caroline Magnani Spagnol, Ana Melero Zaera, Vera Lucia Borges Isaac, Marcos Antonio Corrêa, Hérida Regina Nunes Salgado
Caffeic acid (CA), a phenolic compound found in plants with antioxidant and antimicrobial activity, induces collagen production and prevents premature aging of the skin. The objective of this study was to develop two types of chitosan microparticles (MP) containing CA and to relate the morphology with the release and permeation profiles. One type of MP was prepared from a hydroalcoholic solution (MPI) and the other from an aqueous solution (MPII). Their morphology and size was evaluated by high-resolution scanning electron microscopy...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556131/recent-updates-of-marine-antimicrobial-peptides
#7
REVIEW
Mohammad H Semreen, Mohammed I El-Gamal, Shifaa Abdin, Hajar Alkhazraji, Leena Kamal, Saba Hammad, Faten El-Awady, Dima Waleed, Layal Kourbaj
Antimicrobial peptides are group of proteins showing broad-spectrum antimicrobial activity that have been known to be powerful agents against a variety of pathogens. This class of compounds contributed to solving the microbial resistance dilemma that limited the use of many potent antimicrobial agents. The marine environment is known to be one of the richest sources for antimicrobial peptides, yet this environment is not fully explored. Hence, the scientific research attention should be directed toward the marine ecosystem as enormous amount of useful discoveries could be brought to the forefront...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556130/saudi-vigilance-program-challenges-and-lessons-learned
#8
REVIEW
Adel Alharf, Nasser Alqahtani, Ghazi Saeed, Ali Alshahrani, Mubarak Alshahrani, Nasser Aljasser, Mohammed Alquwaizani, Saleh Bawazir
Pharmacovigilance is vital to public health. Adopting a robust spontaneous reporting system for adverse drug events can counteract most hazards that arise from utilizing medicinal products. Prior to the establishment of the Saudi Food and Drug Authority (SFDA), the number of pharmacovigilance-related activities in Saudi Arabia was limited. In 2009, the SFDA established the National Pharmacovigilance and Drug Safety Center (Saudi Vigilance). The pharmacovigilance system has remarkably improved during the past few years...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556129/flavonoid-glycosides-from-leaves-and-straw-of-oryza-sativa-and-their-effects-of-cytotoxicity-on-a-macrophage-cell-line-and-allelopathic-on-weed-germination
#9
Ill-Min Chung, Sung-Kyu Park, Mohd Ali, Mayakrishnan Prabakaran, Young-Tek Oh, Seung-Hyun Kim, Nasir Ali Siddiqui, Ateeque Ahmad
Five new flavonoids namely, 5-hydroxy-6-isoprenyl-7,4'-dimethoxyflavonol-3- O - β -d-arabinofuranoside ( 1 ), 5,7-dihydroxy-4'-methoxyflavone-7- O - β -d-arabinopyranosyl-2''- n -decan-1'''-oate ( 2 ), 3-butanoyl-5,6,8-trihydroxy-7,4'-dimethoxyflavonol--5- O - β -d-glucopyranoside ( 3 ), 7, 4'-dimethoxy-5-hydroxyflavone-5- O - α -d-arabinopyranosyl-(2'' → 1''')- O - α -d-arabinopyranoside ( 4 ), and 5,6-dihydroxy-7, 4'-dimethoxyflavone-5- O - α -d-glucopyranoside ( 5 ), together with two known compounds, were isolated from the methanol extract of Oryza sativa leaves and straw...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556128/formulation-characterization-cytotoxicity-and-salmonella-microsome-mutagenicity-ames-studies-of-a-novel-5-fluorouracil-derivative
#10
Çinel Köksal Karayildirim, Mustafa Kotmakçi, Erkan Halay, Kadir Ay, Yücel Başpinar
5-Fluorouracil is one of the first line drugs for the systemic therapy of solid tumors like breast, colorectal, oesophageal, stomach, pancreatic, head and neck. It could be shown that sugars can improve the absorption across cell membranes and can help to bypass some pharmacokinetic problems. Carbohydrates as most common organic molecules are an important issue of plant and animal metabolisms. They are non toxic and have important duties in the body like participating in DNA and RNA synthesis and being responsible for energy production...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556127/renewable-poly-%C3%AE-decalactone-based-block-copolymer-micelles-as-drug-delivery-vehicle-in-vitro-and-in-vivo-evaluation
#11
Kuldeep K Bansal, Jitendra Gupta, Ari Rosling, Jessica M Rosenholm
Polymers from natural resources are attracting much attention in various fields including drug delivery as green alternatives to fossil fuel based polymers. In this quest, novel block copolymers based on renewable poly(δ-decalactone) (PDL) were evaluated for their drug delivery capabilities and compared with a fossil fuel based polymer i.e. methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-b-PCL). Using curcumin as a hydrophobic drug model, micelles of PDL block copolymers with different orientation i...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556126/modulation-of-cyp450-als1-and-cox-2-signaling-pathways-induced-by-candida-albicans-infection-via-novel-antifungal-agents
#12
Rehab M Abdel Megeed, Dalia B Fayed, Amira Abood, Mai O Kadry
Although, fluconazole is widely used in clinical treatment as an antifungal drug, it recorded potential problems as resistance and intracellular accumulation. Female albino mice were injected with single ip dose of Candida albicans (1.5 × 106 CFU) . Three weeks post treatment with fluconazole and two novel synthesized compounds [(2-(4-(Pyridin-2-yl) aminosulfonylphenylamino)-6-(naphthalen-2-yl)-4-(pyridin-2-yl) pyridine-3carbonitrile) and (2-(4-(Pyrimidin-2-yl) aminosulfonylphenylamino)-6-(naphthalen-2-yl)-4-(pyridine-2-yl)pyridine-3-carbonitrile) (13b & 14b, respectively)] in both low and high doses (50 mg/kg & 200 mg/kg), liver function and vaginal inflammation were assessed...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556125/self-assembled-filomicelles-prepared-from-polylactide-poly-ethylene-glycol-diblock-copolymers-for-sustained-delivery-of-cycloprotoberberine-derivatives
#13
Xue Liu, Yanxiang Wang, Peng Yun, Xin Shen, Feng Su, Yangsheng Chen, Suming Li, Danqing Song
Polylactide-poly(ethylene glycol) (PLA-PEG) block copolymers were synthesized by ring opening polymerization of l-lactide using a monomethoxy PEG (mPEG) as macroinitiator and zinc lactate as catalyst. The resulting diblock copolymers were characterized by1 H NMR and GPC. Polymeric micelles were prepared by self-assembly of copolymers in distilled water using co-solvent evaporation or membrane hydration methods. The resulting micelles are worm-like in shape as shown by TEM measurements. A hydrophobic anticancer drug, cycloprotoberberine derivative A35, was successfully loaded in PLA-PEG filomicelles with high encapsulation efficiency (above 88%)...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556124/an-epidemiological-study-on-herbal-product-self-medication-practice-among-psychotic-outpatients-from-serbia-a-cross-sectional-study
#14
Gordana Nikolić, Nikola M Stojanović, Pavle J Randjelović, Snežana Manojlović, Niko S Radulović
Utilization of herbal products (HPs) is a common practice in the traditional medicine of people from southeastern Serbia. In this study, we focused on the usage of HPs as a self-medication practice among patients diagnosed with a mental illness, by aiming to ascertain the usage prevalence, the identity of the main plant taxa utilized, their formulations and target symptoms. This was accomplished through a cross-sectional study of psychiatric outpatients, conducted in the Clinic for Mental Health Protection in Niš, and which included a questionnaire on HP utilization and a non-structured psychiatric interview...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556123/curcumin-and-piperine-loaded-zein-chitosan-nanoparticles-development-and-in-vitro-characterisation
#15
Yücel Baspinar, Mehmet Üstündas, Oguz Bayraktar, Canfeza Sezgin
Curcumin as the active compound of turmeric has antioxidative, antiinflammatory, antimicrobial and anticancer properties among others. However, its disadvantageous properties like low solubility, poor bioavailability and rapid degradation under neutral or alkaline pH conditions or when exposed to light limit its clinical application. These problems can be solved by a smart combination of using a natural enhancer like piperine and preparing nanoparticles by a proper method like electrospray. Due to these facts it was aimed in this study to develop curcumin and piperine loaded zein-chitosan nanoparticles step by step...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556122/phenolic-compounds-from-viscum-album-tinctures-enhanced-antitumor-activity-in-melanoma-murine-cancer-cells
#16
Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, Adalgisa Felippe Wiecikowski, Renato Sampaio Carvalho, Juliana de Lima Castro, Felipe Alves Gomes de Oliveira, Henrique Marcelo Gualberto Pereira, Venicio Feo da Veiga, Marcia Marques Alves Capella, Leandro Rocha, Carla Holandino
Cancer is one of the biggest problems in public health worldwide. Plants have been shown important role in anticancer research. Viscum album L. (Santalaceae), commonly known as mistletoe, is a semi-parasitic plant that grows on different host trees. In complementary medicine, extracts from European mistletoe ( Viscum album L.) have been used in the treatment of cancer. The study was conducted to identify chemical composition and antitumor potential of Viscum album tinctures. Chemical analysis performed by high resolution chromatography equipped with high resolution mass spectrometer identified caffeic acid, chlorogenic acid, sakuranetin, isosakuranetin, syringenin 4-O-glucoside, syringenin 4-O-apiosyl-glucoside, alangilignoside C and ligalbumoside A compounds...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556121/pregabalin-dispensing-patterns-in-amman-jordan-an-observational-study-from-community-pharmacies
#17
Amneh Al-Husseini, Rana Abu-Farha, Mayyada Wazaify, Marie Claire Van Hout
Objectives: Pregabalin is currently approved for the treatment of epilepsy, generalized anxiety disorder, neuropathic pain and fibromyalgia. Rising attention to the abuse liability of pregabalin causing addictive behaviors is partially based on case reports and published literature of pregabalin used in dosages that override the approved therapeutic range. This study was conducted to provide background data regarding the abuse/misuse of pregabalin from community pharmacy in Jordan. Methods: A prospective cross-sectional observational study design was used, which was conducted at different community pharmacies in Amman-Jordan...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29556120/a-focus-group-study-of-patient-s-perspective-and-experiences-of-type-2-diabetes-and-its-management-in-jordan
#18
Anan S Jarab, Tareq L Mukattash, Ahmad Al-Azayzih, Maher Khdour
Background: Diabetes is increasingly becoming a major health problem in Jordan and glycemic goals are often not achieved. Objective: To explore the patients' perspectives regarding type 2 diabetes and its management in order to "fine-tune" future pharmaceutical care intervention programs. Method: Focus groups method was used to explore views from individuals with type 2 diabetes attending outpatient diabetes clinic at the Royal Medical Services Hospital...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29379347/association-between-satisfaction-with-and-adherence-to-warfarin-therapy-on-the-control-of-international-normalized-ratio-a-hospital-based-study-in-saudi-arabia
#19
Balkhi Balkhi, Mabrouk Al-Rasheedi, Abuabker Ibrahim Elbur, Ahmad Alghamadi
Background: High satisfaction with, and adherence to, warfarin therapy are linked to better international normalized ratio (INR) control and good therapeutic outcomes. Objective: This study was conducted to identify the association between satisfaction with, and adherence to, warfarin therapy and the control of the INR within the target therapeutic range. Methods: A cross-sectional study was conducted from June 1 to August 31, 2016, at the Anticoagulation Clinic in the Cardiology Center at King Fahad Hospital, Qassim, Saudi Arabia...
January 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29379346/novel-quinazoline-and-acetamide-derivatives-as-safe-anti-ulcerogenic-agent-and-anti-ulcerative-colitis-activity
#20
Fatmah A S Alasmary, Amani S Awaad, Ahmed M Alafeefy, Reham M El-Meligy, Saleh I Alqasoumi
Two novel quinazoline derivatives named as; 3-[(4-hydroxy-3-methoxy-benzylidene)-amino]-2- p- tolyl-3 H -quinazolin-4-one ( 5 ) and 2- p -Tolyl-3-[3,4,5-trimethoxy-benzylidene-amino]-3 H -quinazolin-4-one ( 6 ) in addition to one acetamide derivative named as 2-(2-Hydroxycarbonylphenylamino)- N -(4-aminosulphonylphenyl) 11 were synthesized, and evaluated for their anti-ulcerogenic & Anti-Ulcerative colitis activities. All of the three compounds showed curative activity against acetic acid induced ulcer model at a dose of 50 mg/kg, they produced 65%, 85% & 57...
January 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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