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Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society

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https://www.readbyqxmd.com/read/30532641/effect-of-treatment-with-vitamin-d-plus-calcium-on-oxidative-stress-in-streptozotocin-induced-diabetic-rats
#1
Fatema Suliman Alatawi, Uzma A Faridi, Mohsen Suliaman Alatawi
Background: In diabetes mellitus, uncontrolled hyperglycemia has been reported to induce oxidative stress, which may lead to health complications. Vitamin D, however, acts as a non-enzymatic antioxidant to protect cells against oxidative stress and damage. Objective: To investigate the antioxidative effect of vitamin D combined with calcium in streptozotocin (STZ)-induced diabetic rats. Methods: Rats were divided into four groups (ten rats in each group)...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532640/green-chromatographic-method-for-analysis-of-some-anti-cough-drugs-and-their-toxic-impurities-with-comparison-to-conventional-methods
#2
Eglal A Abdelaleem, Nada S Abdelwahab
Toxic solvents are widely used in chemical laboratories, which are dangerous on health, safety of workers, and environment. Green chemistry established different principles to keep safety of environment, one of these goals is to replace toxic solvents by greener alternatives or by minimizing the used volumes. Paracetamol (PAR), Guaifenesin (GUF), Oxomemazine (OX), and Sodium benzoate (SB) combination is a widely used cough preparation. 4- aminophenol (4-AP) is PAR poisonous impurity and related substance. Guiacol (GUC) is GUF impurity and related substance; its presence may lead to rejection of GUF sample...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532639/ginkgolide-c-reduced-oleic-acid-induced-lipid-accumulation-in-hepg2-cells
#3
Wen-Chung Huang, Ya-Ling Chen, Hui-Chia Liu, Shu-Ju Wu, Chian-Jiun Liou
Ginkgolide C, isolated from Ginkgo biloba , is a diterpene lactone that has multiple biological functions and can improve Alzheimer disease and platelet aggregation. Ginkgolide C also inhibits adipogenesis in 3T3-L1 adipocytes. The present study evaluated whether ginkgolide C reduced lipid accumulation and regulated the molecular mechanism of lipogenesis in oleic acid-induced HepG2 hepatocytes. HepG2 cells were treated with 0.5 mM oleic acid for 48 h to induce a fatty liver cell model. Then, the cells were exposed to various concentrations of ginkgolide C for 24 h...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532638/an-approach-to-enhanced-stability-formulation-and-characterization-of-solanum-lycopersicum-derived-lycopene-based-topical-emulgel
#4
Muhammad Sohail, Akhtar Naveed, Rouf Abdul, Gulfishan, Hajji Muhammad Shoaib Khan, Hira Khan
Focus of the study was to design a novel and cost effective extraction technique for the lycopene from Lycopersicum esculentum L. fruit and to develop and characterize a stable emulgel formulation containing lycopene as an active ingredient as well as to design an analytical method to determine lycopene concentration in emulgel. Emulgel formulation was prepared and evaluated for its stability at different storage conditions, 8 °C, 25 °C, 40 °C, 40 °C + 75% relative humidity (RH) and 50 °C, for 6 months...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532637/targeting-of-somatostatin-receptors-expressed-in-blood-cells-using-quantum-dots-coated-with-vapreotide
#5
Ahmed A H Abdellatif, Heba A Abou-Taleb, Ahmed A Abd El Ghany, Ilka Lutz, Abdellatif Bouazzaoui
Cancer may be difficult to target, however, if cancer targeted this provides the chance for a better and more effective treatment. Q uantum dots (Qdots) coated vapreotide (VAP) as a somatostatin receptors (SSTRs) agonist can be efficient targeting issue since may reduce side effects and increase drug delivery to the target tissue. This study highlights the active targeting of cancer cells by cells imaging with improving the therapeutic outcomes. VAP was conjugated to Qdots using amine-to-sulfhydryl crosslinker...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532636/trigger-tools-are-as-effective-as-non-targeted-chart-review-for-adverse-drug-event-detection-in-intensive-care-units
#6
Renato R Martins, Lunara T Silva, Gabriela G Bessa, Flavio M Lopes
Objective: This study aimed to compare the use of trigger tools and non-targeted chart review as methods for the detection of adverse drug events in an intensive care unit considering the health system of a developing country. Methods: Patients were divided in groups that were submitted to different methods (trigger tool and non-targeted chart review) for adverse drug event detection. Medical records were retrospectively reviewed, and adverse drug events detected during the data collection were analyzed by a multidisciplinary team and classified according to their causality, predictability, severity and damage level...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532635/prevalence-of-torsades-de-pointes-inducing-drugs-usage-among-elderly-outpatients-in-north-jordan-hospitals
#7
Ahmad Al-Azayzih, Sara Gharaibeh, Anan S Jarab, Tareq L Mukattash
Background: Torsade de Pointes (TdP) is an abnormal cardiac rhythm associated with a prolongation of QT interval. Although in most cases it spontaneously returns to the normal rhythm, TdP can lead to sudden cardiac death. Medications are the main cause of QT-prolongation and subsequent TdP flare, even though the exact mechanism of why some people evoke TdP but others do not is still unknown. It is evident that elderly patients are more susceptible to experience drug's side effects especially with chronically used medications...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532634/zingerone-4-4-hydroxy-3-methylphenyl-butan-2-one-protects-against-alloxan-induced-diabetes-via-alleviation-of-oxidative-stress-and-inflammation-probable-role-of-nf-kb-activation
#8
Bilal Ahmad, Muneeb U Rehman, Insha Amin, Manzoor Ur Rahman Mir, Sheikh Bilal Ahmad, Adil Farooq, Showkeen Muzamil, Ishraq Hussain, Mubashir Masoodi, Bilques Fatima
Diabetes is considered as the most common metabolic disease affecting millions of people all around the world. Use of natural herbal medicines can be effective in treating diabetes. Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) a polyphenolic alkanone extracted from ginger has a broad spectrum of pharmacological properties and thus can be used as a promising candidate against various ailments. In the current study we aimed at demonstrating the protective effect of zingerone against diabetes mellitus and elucidating its possible mechanism...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532633/inhaler-technique-education-and-asthma-control-among-patients-hospitalized-for-asthma-in-jordan
#9
Iman A Basheti, Nathir M Obeidat, Helen K Reddel
Objectives: To investigate the effect of inhaler technique education delivered by a clinical pharmacist to patients hospitalised for asthma, on inhaler technique scores and asthma control at three months post-discharge. Methods: This pre-post interventional study in Jordan enrolled patients who had been admitted for asthma and were using controller medication by Accuhaler [Diskus] (ACC), Turbuhaler (TH) or Pressurized metered dose inhalers (pMDI). Inhaler technique was assessed using published checklists (score 0-9)...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532632/radioiodination-and-biodistribution-of-newly-synthesized-3-benzyl-2-3-methoxybenzyl-thio-benzo-g-quinazolin-4-3-h-one-in-tumor-bearing-mice
#10
Rashad Al-Salahi, Moustapha E Moustapha, Hatem A Abuelizz, Abdulrahman I Alharthi, Khalid A Alburikan, Ismail T Ibrahim, Mohamed Marzouk, Mohamed A Motaleb
3-Benzyl-2-((3-methoxybenzyl)thio)benzo[ g ]quinazolin-4(3 H )-one was previously synthesized and proved by physicochemical analyses (HRMS, 1 H and 13 C NMR). The target compound was examined for its radioactivity and the results showed that benzo[ g ]quinazoline was successfully labeled with radioactive iodine using NBS via an electrophilic substitution reaction. The reaction parameters that affected the labeling yield such as concentration, pH and time were studied to optimize the labeling conditions. The radiochemical yield was 91...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532631/the-prevalence-of-benzodiazepines-utilization-and-its-association-with-falls-among-saudi-older-adults-results-from-the-saudi-national-survey-for-elderly-health-snseh
#11
Mohammad H Aljawadi, Abdullah T Khoja, Abdullah M Alhammad, Azzam D AlOtaibi, Sulaiman A Al-Shammari, Tawfik A Khoja
Purpose: First, to determine benzodiazepines prevalence (BDZs) among Saudi older adults (SOA); Second, to quantify the association between BDZs use and falls among SOA. Third, to determine falls effect on all-cause mortality among SOA. Methods: This is a cross-sectional study that used the Saudi National Survey for Elderly Health; a nationally-representative, population-based survey. Participants were asked about BDZs use and falls history during the 12 months prior to the interview...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532630/animal-use-in-pharmacy-undergraduate-pharmacology-laboratories-students-perceptions-and-need-assessments
#12
Feras D Elhajji, Iman A Basheti
Background: During the undergraduate years, laboratory practical classes using experimental animals are important in pharmacy schools. Limitations for experimental use of animals exist, including the procurement of animals, the difficulty in performing animal experiments, ethical considerations, and more often students' preferences. Objective: To evaluate pharmacy students' perceptions, barriers, and confidence regarding animal use in the pharmacology laboratory course, and the effect of animal handling on their confidence...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532629/identification-and-characterization-of-a-novel-antimicrobial-peptide-compound-produced-by-bacillus-megaterium-strain-isolated-from-oral-microflora
#13
Abdullah S A Al-Thubiani, Yahia A Maher, Adel Fathi, Mohammed A S Abourehab, Mohammed Alarjah, Mohd S A Khan, Saleh B Al-Ghamdi
In recent years, the decreased efficacy of existing antibiotics toward management of emergent drug-resistant strains has necessitated the search for novel antibiotics from natural products. In this regard, Bacillus sp is well known for producing variety of secondary metabolites of potential use. Therefore, we performed an investigation to isolate and identify Bacillus sp from oral cavity for production of novel antimicrobial compounds. We extracted, purified, and identified a novel bioactive compound by B. megaterium (KC246043...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532628/stat3-sirna-induced-b16-f10-melanoma-cell-death-more-association-with-vegf-downregulation-than-p-stat3-knockdown
#14
Aws Alshamsan
STAT3 knockdown by small interfering RNA (siRNA) has been described to inhibit carcinogenic growth in various types of tumors. Earlier we have reported delivery of siRNA by oleic acid- and stearic acid-modified-polyethylenimine and enhancement of silencing of STAT3 by small interfering RNA (siRNA) in B16.F10 melanoma cell lines and consequent tumor suppression. Present investigation mainly focused on the downstream events involved in B16.F10 melanoma cell death and consequent tumor suppression following knockdown of p-STAT3 by siRNA...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532627/effect-of-poplar-type-propolis-on-oxidative-stability-and-rheological-properties-of-o-w-emulsions
#15
Soukaina El-Guendouz, Smail Aazza, Badiaa Lyoussi, Nessrine Majdoub, Vassya Bankova, Milena Popova, Sara Raposo, Maria Dulce Antunes, Maria Graça Miguel
Propolis is known to possess antioxidant activity. However, there is no information on this activity in emulsions O/W. The protective effect of propolis on the oxidation and rheological properties of emulsions O/W containing wheat germ and almond oils was evaluated. Emulsions O/W were prepared with different concentration of propolis extract, almond oil and wheat germ oil. All emulsions physically stable without phase separation were stored at 37 °C for 9 weeks. Chemical composition of propolis was established by Gas chromatography coupled to mass spectrometry...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30532626/novel-plant-inducers-of-pxr-dependent-cytochrome-p450-3a4-expression-in-hepg2-cells
#16
Mohammed S Al-Dosari, Mohammad K Parvez
The cytochrome P450 3A4 (CYP3A4) is the most abundant CYP450 enzyme involved in the metabolism of endogenous products and xenobiotics, including prescription drugs and herbals. Modulation of hepatic CYP3A4 gene expression via nuclear receptors, like pregnane X receptor (PXR), is a major cause of adverse effects like drug-unresponsiveness and toxicity. In the present study, ethanol extracts of 58 medicinal plants, belonging to 27 families, were evaluated for potential activities in CYP3A4 induction in HepG2 cells by reporter gene assay...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30510473/pharmacists-interventions-to-reduce-sedative-hypnotic-use-for-insomnia-in-hospitalized-patients
#17
Aisha F Badr, Sawsan Kurdi, Samah Alshehri, Claire McManus, Jeannie Lee
Background: Hospitalization can contribute to insomnia in many patients and is usually treated symptomatically. However, sedative/hypnotic misuse is associated with complications in this population, especially in the elderly. Such complications include dizziness, falls and over-sedation. Due to the implicit dangers, widespread use of these drugs for insomnia, particularly in older patients, has been discouraged by many hospitals. The aim of this study was to review and evaluate prescribing patterns and to optimize the use of the sedative/hypnotic agents through daily pharmacy interventions at a community hospital...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30510472/evaluation-of-the-role-of-cdkn2b-gene-in-type-2-diabetes-mellitus-and-hypertension-in-ethnic-saudi-arabs
#18
Maha Meshal AlRasheed
Background: Coronary heart disease (CAD) is a multiple with several contributory risk traits, including type 2 diabetes and hypertension, which may share common genetic risk variants with the disease. Genome-wide association studies (GWASs) have yielded a wealth of information suggesting that CAD, the extent of contributory variants may differ according to genetic locus. The present study aimed at verifying whether the cyclin-dependent kinase 4 inhibitor B ( CDKN2B ) genomic region strongly associated with coronary artery disease (CAD)/myocardial infarction (MI) may also constitute risk for its risk factors type 2 diabetes mellitus (T2DM) and hypertension (HTN) in ethnic Saudi Arabs...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30510471/the-impact-of-dapagliflozin-on-glucose-excursions-related-to-early-proatherogenic-derangement-in-the-aortic-wall
#19
Agnieszka Stelmaszyk, Anna Wesołowska, Karolina Pomieczyńska, Saule Iskakova, Magdalena Frydrychowicz, Grzegorz Dworacki, Marzena Dworacka
Introduction: Cardiovascular risk in the course of diabetes depends greatly on glycemic variability which is even more significant than chronic hyperglycemia. Optimal management of diabetes involves a multidisciplinary approach focused in particular on decreasing the risk of atherosclerosis. Therefore, our purpose was to evaluate the impact of dapagliflozin on glucose excursions and related proatherogenic changes in the aortic wall. Methods and materials: Animal model of type 2 diabetes rich-fat/STZ rats was used...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/30510470/the-use-of-social-media-among-saudi-residents-for-medicines-related-information
#20
Mahmoud S Alhaddad
This study aimed to measure the use of social media applications for health information among residents in Saudi Arabia. A cross sectional study was adopted in this study between 20th of September to 1st of December 2017. A pre-validated questionnaire was either distributed through face to face to respondents in public areas or through online survey which was posted to main social media groups in Saudi Arabia. All data was analyzed through using SPSS version 22.0. All p-values of less than 0.05 were considered significant...
December 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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