Chaojun Zhu, Lan Teng, Yihong Lai, Xingxing Yao, Yuxin Fang, Zihuan Wang, Simin Lin, Haonan Zhang, Qingyuan Li, Ye Li, Jianqun Cai, Yue Zhang, Changjie Wu, Bing Huang, Aimin Li, Side Liu, Qiuhua Lai
Peritoneal metastasis, the third most common metastasis in colorectal cancer (CRC), has a poor prognosis for the rapid progression and limited therapeutic strategy. However, the molecular characteristics and pathogenesis of CRC peritoneal metastasis are poorly understood. Here, we aimed to elucidate the action and mechanism of adipose-derived stem cells (ADSCs), a prominent component of the peritoneal microenvironment, in CRC peritoneal metastasis formation. Database analysis indicated that ADSCs infiltration was increased in CRC peritoneal metastases, and high expression levels of ADSCs marker genes predicted a poor prognosis...
April 21, 2024: Cellular and Molecular Life Sciences: CMLS