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Journal of Lower Genital Tract Disease

Rebecca Jackson, Li Wang, Nathaniel Jembere, Joan Murphy, Rachel Kupets
OBJECTIVE: The aim of the study was to determine factors associated with the development of cervical malignancy among women participating in an organized cervical screening program. MATERIALS AND METHODS: A population-based retrospective cohort study was performed examining the screening histories 2 to 10 years before diagnosis of invasive cancer in Ontario women between 2011 and 2014. RESULTS: A total of 2,002 cases of cervical cancer were identified; 1,358 (68%) were squamous cell carcinomas and 644 (32%) were adenocarcinomas...
November 27, 2018: Journal of Lower Genital Tract Disease
Colin MacNeill, Glendell S de Guzman, Kate Lupo, Todd Umstead, David S Phelps, Joanna Floros
OBJECTIVE: The aim of the study was to test the hypothesis that vaginal administration of surfactant lipids, which may counter-balance the proinflammatory effects of vaginal surfactant protein A, will decrease proinflammatory cytokines and increase anti-inflammatory cytokines in vaginal mucosal fluid in healthy women. MATERIALS AND METHODS: Three groups of healthy cycling women were randomized to receive vaginally a single dose of the following: (1) low-dose calfactant, a type of surfactant lipids, 0...
November 27, 2018: Journal of Lower Genital Tract Disease
Pedro Vieira-Baptista, Joana Lyra, Catarina Melo, Filipa Almeida, Joana Lima-Silva
No abstract text is available yet for this article.
November 17, 2018: Journal of Lower Genital Tract Disease
Qing Cong, Zhongpeng Fu, Di Zhang, Long Sui
OBJECTIVE: The aim of the study was to investigate the value of cytology, high-risk human papillomavirus (hrHPV) status and colposcopy in the early diagnosis of vaginal cancer after hysterectomy. MATERIALS AND METHODS: A retrospective study was performed in the Obstetrics and Gynecology Hospital of Fudan University. Posthysterectomy patients who were diagnosed with vaginal high-grade intraepithelial lesion (HSIL) by colposcopy-directed biopsy with colposcopy impression of extensive HSIL or suspicion of cancer and underwent upper or total vaginectomy from January 2009 to December 2017 were included...
November 7, 2018: Journal of Lower Genital Tract Disease
Limor Kalfon, Audrey Azran, Yaniv Farajun, Oshrat Golan-Hamu, Aylah Toben, Liora Abramov, Arie Yeshaya, Orly Yakir, Doron Zarfati, Tzipora C Falik Zaccai, Jacob Bornstein
OBJECTIVE: The aim of the study was to study the associations between localized provoked vulvodynia (LPV) and several single-nucleotide polymorphisms (SNPs) in the transient receptor potential vanilloid type 1 (TRPV1), nerve growth factor (NGF), and the heparanase (HPSE) genes. MATERIALS AND METHODS: Prevalence of SNPs among 65 women with moderate or severe primary LPV (initial symptoms occur with first provoking physical contact) and 126 healthy, ethnically matched controls was analyzed in an observational case-control study...
November 7, 2018: Journal of Lower Genital Tract Disease
Daron G Ferris, Teresa M Darragh, Sravan Kavuri, Nikhil Patel, Jennifer L Waller, Angela Goebel
OBJECTIVE: The objective of this study was to determine the performance characteristics of the Tush brush (TB) compared with a saline moistened Dacron swab (DS) as anal cytology sampling devices. MATERIALS AND METHODS: TB and DS anal cytology tests were randomly collected from 146 patients presenting for anal cytology. High-resolution anoscopy and biopsies were obtained as indicated. Sensitivity and specificity as well as rates of satisfactory specimens were determined for each method using the areas under the receiver operating characteristic curve (AUCROC) and McNemar's test, respectively...
November 7, 2018: Journal of Lower Genital Tract Disease
Erin Wilson, Sarah Janssens, Dora Ng, Brian Jolly, David G Hewett, Michael Beckmann
OBJECTIVE: The aim of the study was to review the performance of trainees in loop electrosurgical excision procedure (LEEP) procedures after the introduction of a simulation training program. MATERIALS AND METHOD: A simulation training program was introduced in September 2016 for gynecology trainees at the study institution. Trainees were encouraged to perform at least 3 simulated LEEP procedures before operating. For a 12-month period after the introduction of training, data on operating time and specimen quality measures of clear margin status, adequate depth, and absence of fragmentation were reviewed...
October 29, 2018: Journal of Lower Genital Tract Disease
Fabio Bottari, Anna Daniela Iacobone, Sara Boveri, Eleonora Petra Preti, Dorella Franchi, Luciano Mariani, Mario Preti, Fabio Landoni, Rita Passerini, Maria Teresa Sandri
OBJECTIVE: Many methods are available today for human papillomavirus (HPV) testing; they differ for technology, targets, and information on the genotypes detected. In this study, we evaluated the performance of the Onclarity HPV assay in detection and follow-up of cervical preneoplastic lesions. MATERIALS AND METHODS: One hundred sixty-seven women referred to the European Institute of Oncology, Milan, for treatment of cervical lesions were enrolled. We investigated the utility of Onclarity extended genotyping HPV test in the management of cervical intraepithelial neoplasia (CIN) 2+ preneoplastic lesion...
October 26, 2018: Journal of Lower Genital Tract Disease
Limei Chen, Li Liu, Xiang Tao, Luopei Guo, Hongwei Zhang, Long Sui
OBJECTIVE: The aim of the study was to analyze the clinical outcomes of high-grade squamous intraepithelial lesion (HSIL) 6 months after loop electrosurgical excision procedure (LEEP). We explored the risk factors of persistent cervical HSIL after LEEP and evaluated the methods of follow-up. PATIENTS AND METHODS: This retrospective study included women who underwent a LEEP and had a diagnosis of HSIL in their LEEP specimen during 2011 to 2015. The purpose was to determine the risk factors among these women for having persistent HSIL disease at their 6-month follow-up visit...
October 26, 2018: Journal of Lower Genital Tract Disease
Jhalak Dholakia, Deborah Bartholomew
No abstract text is available yet for this article.
October 1, 2018: Journal of Lower Genital Tract Disease
Munetoshi Akazawa, Toshiaki Saito, Masao Okadome, Kazuya Ariyoshi
OBJECTIVE: The aim of this study was to compare the outcomes associated with the use of a novel monopolar scalpel with those associated with the use of an ultrasonic scalpel for cervical conization of cervical intraepithelial neoplasia. MATERIALS AND METHODS: We conducted a retrospective cross-sectional study in patients treated in our institute between April 2010 and March 2017. We used either the VIO monopolar scalpel (VIO) or Harmonic ultrasonic scalpel (HS) for cervical conization...
September 26, 2018: Journal of Lower Genital Tract Disease
Panteha Eshtiaghi, Leslie Ann Sadownik
OBJECTIVE: The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS). MATERIALS AND METHODS: PubMed/MEDLINE, Ovid, Web of Science, and were searched from inception up to May 7, 2018. RESULTS: Seven observational studies were identified, with a total of 98 patients. Both ADSCs and PRP were reported to improve symptoms, quality of life measures, as well as clinical and histological signs of vulvar LS...
September 24, 2018: Journal of Lower Genital Tract Disease
Cathrin Alvendal, Witchuda Kamolvit, Siegfried Wagner, Annelie Brauner, Nina Bohm-Starke
OBJECTIVES: Persistent infection with human papillomavirus causes cervical high-grade squamous intraepithelial lesions (HSILs). The role of antimicrobial peptides (AMPs) in premalignant and malignant transformation is not fully understood. In this study, we examined the expression of human β-defensin 1 (HBD-1), HBD-2, HBD-3, LL37, psoriasin, and interleukin 8 (IL-8) in women with HSIL before and 6 months after surgery. MATERIALS AND METHODS: Biopsies and secretion samples from the cervical canal were collected from 19 patients with HSIL and 14 healthy controls...
September 20, 2018: Journal of Lower Genital Tract Disease
Mark B Woodland, Laura Callanan, Peter F Schnatz, Xuezhi Jiang
OBJECTIVE: The aim of the study was to promote the importance of providing gynecologic screening for transgender men (TGM) who desire to keep their female organs. MATERIALS AND METHODS: In June 2015, the Women's Health Center (WHC) at Reading Hospital was approached to become a resource for transgender (TG) patients in our community. This also presented the opportunity to develop an educational program for OBGYN residents/providers in TG healthcare. From June 2015 to August 2016, we educated ourselves, established standards of care, collaborated with other services, and reached out to the community we represent...
October 2018: Journal of Lower Genital Tract Disease
Molly Lieber, Christopher W Reynolds, Whitney Lieb, Stephen McGill, Ann Marie Beddoe
OBJECTIVE: The aim of this study was to assess human papillomavirus (HPV) prevalence, knowledge, attitudes, and practices, among men who have sex with men (MSM) in Monrovia, Liberia. MATERIALS AND METHOD: This cross-sectional study was conducted with 107 MSM, aged 18 to 58 years, completing questionnaires and anal HPV screenings. Using peer-educators and direct community involvement, demographics, risk factors, and HPV knowledge data were collected. RESULTS: Forty-eight participants (45%) were HPV positive and 21 participants (19...
October 2018: Journal of Lower Genital Tract Disease
Sarah Feldman, Erin Cook, Michelle Davis, Susan T Gershman, Amresh Hanchate, Jennifer S Haas, Rebecca B Perkins
IMPORTANCE: Current cancer screening guidelines recommend cessation of cervical cancer screening at the age of 65 years for most women. To examine residual risk among elderly women, we compared cervical cancer incidence rates (IRs) in Massachusetts from 2004 to 2015 among women younger than 65 years versus 65 years and older. MATERIALS AND METHODS: The Massachusetts Cancer Registry was used to identify all women diagnosed with cervical cancer between January 01, 2004, to December 31, 2015...
October 2018: Journal of Lower Genital Tract Disease
Cortney Eakin, Rodrigue Ekollo, Derick Nembulefack, Gregory Halle-Ekane, Gracious Tangui, Robert Brady, Bikash Bhattarai, George Enow Orock, David Greenspan
OBJECTIVE: The aim of the study was to determine beliefs and utilization of cervical cancer screening and prevalence of low-grade squamous intraepithelial lesion/high-grade squamous intraepithelial lesion among a university-based population in the Southwest region of Cameroon. MATERIALS AND METHODS: A public-private partnership was established between the University of Arizona, University of Buea, and the Cameroon Baptist Convention Health Services. A single-day screening clinic using visual inspection with acetic acid and Lugol's iodine solution (VILI) was provided at the University of Buea...
October 2018: Journal of Lower Genital Tract Disease
Kimberly A Kilfoyle, Andrea C Des Marais, Mai Anh Ngo, LaHoma Romocki, Alice R Richman, Lynn Barclay, Noel T Brewer, Lisa Rahangdale, Jennifer S Smith
OBJECTIVES: Self-collection of samples for human papillomavirus (HPV) testing (self-collection) has the potential to increase cervical cancer screening among underscreened women. We assessed attitudes toward at-home HPV self-collection compared with clinic-based Pap testing in this higher-risk population. MATERIALS AND METHODS: Participants were low-income women in North Carolina overdue for cervical cancer screening. Women self-collected samples at home, returned samples by mail for HPV testing, and completed phone questionnaires about at-home HPV self-collection...
October 2018: Journal of Lower Genital Tract Disease
Amelia B Thompson, Scott E Gillespie, Marina B Mosunjac, Sophia A Hussen, Lisa C Flowers, Andres F Camacho-Gonzalez
OBJECTIVE: Anal cancer rates are increasing among HIV-infected persons. Although an efficacious human papillomavirus (HPV) vaccine is available, HPV vaccination rates remain low. Therefore, providers perform anal cancer screening, but there is no consensus on the optimal methods or timing of screening. This study was performed to determine the prevalence of and factors associated with anal squamous intraepithelial lesions in sexually active HIV-infected young men who have sex with men and transgender women...
October 2018: Journal of Lower Genital Tract Disease
Anna-Barbara Moscicki, Rebecca B Perkins, Marion Saville, Julia M L Brotherton
No abstract text is available yet for this article.
October 2018: Journal of Lower Genital Tract Disease
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