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CNS Spectrums

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https://www.readbyqxmd.com/read/28807062/neuropsychiatric-characteristics-of-antiterrorist-operation-combatants-in-the-donbass-ukraine
#1
Konstantin N Loganovsky, Natalia A Zdanevich, Marina V Gresko, Donatella Marazziti, Tatiana K Loganovskaja
OBJECTIVE: The present paper aimed to explore the neuropsychiatric characteristics of the antiterrorism (ATO) combatants in the Donets Basin (Donbass) and to propose therapeutic strategies for managing their mental healthcare. METHODS: A total of 54 ATO combatants were included in our study and compared with four groups of subjects exposed to other emergencies, including the Chernobyl disaster and the war in Afghanistan. The neuropsychiatric features were assessed through psychopathological assessments, neurological examinations, and quantitative electroencephalography (qEEG)...
August 15, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28803592/brain-alterations-potentially-associated-with-aggression-and-terrorism
#2
Bernhard Bogerts, Maria Schöne, Stephanie Breitschuh
A large proportion of the persons who join terrorist groups as well as lone-acting terrorists have a history of violent behavior or mental disorder that predated their becoming terrorists. This suggests that brain alterations found to occur in violent perpetrators may also be present in a significant percentage of terrorists. After a short delineation of phylogenetically old neuronal networks that are important for the generation of aggressive behavior in inconspicuous brains, this review summarizes structural and functional brain-imaging studies in violent offenders published over the last 10 years...
August 14, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28766471/why-is-terrorism-a-man-s-business
#3
Anne Maria Möller-Leimkühler
Terrorism, whether it is group-related or performed as lone actor terrorism, is a predominantly male phenomenon. Generally and throughout history, young males have been the main protagonists of criminal and political violence. This article aims to contribute, from different perspecives, to the question of what makes young men violent. These include neurobiological aspects, such as sex differences in the brain that predispose males to physical aggression and violence; gender role aspects, with regard to aggression and violence being basic components for demonstrating and reconstructing masculinity; demographic aspects of male youth bulges as potential breeding grounds for terrorism; aspects of group dynamics and identity fusion in the process of radicalization; and psychosocial characteristics of lone actor terrorists, which differ from group-related terrorists...
August 2, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28766469/the-forsaking-of-the-clinical-eeg-by-psychiatry-how-justified
#4
Nash N Boutros
Despite decades of publications attesting to the role of the clinical EEG in diagnosing and managing psychiatric disorders, the procedure remains highly underutilized in the practice of psychiatry. The visually inspected EEG (vEEG) can detect various forms of abnormalities, each with its own clinical significance. Abnormalities can be paroxysmal (i.e., suggestive of an epileptic-like process) or stationary. The most important unanswered question remains the value of detecting epileptiform activity in a nonepileptic psychiatric patient in predicting favorable responses to anticonvulsant treatment...
August 2, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28683846/beyond-the-pill-new-medication-delivery-options-for-adhd
#5
Andrew J Cutler, Gregory W Mattingly
Successful treatment of pediatric disorders has necessitated the development of alternative medication formulations, as children may prefer alternative dosage forms to tablets or capsules. This is especially true for attention-deficit/hyperactivity disorder (ADHD), which is one of the most common chronic pediatric conditions and often involves children with a variety of overlapping physical, psychological, or neurodevelopmental disorders. A special challenge for developing alternative dosage forms for ADHD treatment is the incorporation of a once-daily long-acting formulation...
July 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28669371/the-following-abstracts-were-presented-as-posters-at-the-2016-nei-psychopharmacology-congress-corrigendum
#6
(no author information available yet)
No abstract text is available yet for this article.
July 3, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28659221/qtc-interval-in-patients-with-schizophrenia-receiving-antipsychotic-treatment-as-monotherapy-or-polypharmacy
#7
Anja Elliott, Thibault Johan Mørk, Mikkel Højlund, Thomas Christensen, Rasmus Jeppesen, Nikolaj Madsen, Anne Grethe Viuff, Peter Hjorth, Jens Cosedis Nielsen, Povl Munk-Jørgensen
OBJECTIVE: Antipsychotics are associated with a polymorphic ventricular tachycardia, torsades de pointes, which, in the worst case, can lead to sudden cardiac death. The QT interval corrected for heart rate (QTc) is used as a clinical proxy for torsades de pointes. The QTc interval can be prolonged by antipsychotic monotherapy, but it is unknown if the QTc interval is prolonged further with antipsychotic polypharmaceutical treatment. Therefore, this study investigated the associations between QTc interval and antipsychotic monotherapy and antipsychotic polypharmaceutical treatment in schizophrenia, and measured the frequency of QTc prolongation among patients...
June 29, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28659216/response-to-the-letters-addressing-much-ado-about-nothing
#8
Ken Gillman
No abstract text is available yet for this article.
June 29, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28631584/clinical-characterization-of-italian-suicide-attempters-with-bipolar-disorder
#9
Bernardo Dell'Osso, Matteo Vismara, Cristina Dobrea, Laura Cremaschi, Benedetta Grancini, Chiara Arici, Beatrice Benatti, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
Introduction Bipolar disorder (BD) is a chronic, highly disabling condition associated with psychiatric/medical comorbidity and substantive morbidity, mortality, and suicide risks. In prior reports, varying parameters have been associated with suicide risk. OBJECTIVES: To evaluate sociodemographic and clinical variables characterizing Italian individuals with BD with versus without prior suicide attempt (PSA). METHODS: A sample of 362 Italian patients categorized as BD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM IV-TR) was assessed and divided in 2 subgroups: with and without PSA...
June 20, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28625204/effect-of-aripiprazole-lauroxil-in-patients-with-acute-schizophrenia-as-assessed-by-the-positive-and-negative-syndrome-scale-supportive-analyses-from-a-phase-3-study
#10
Leslie Citrome, Robert Risinger, Andrew J Cutler, Yangchun Du, Jacqueline Zummo, Henry A Nasrallah, Bernard L Silverman
OBJECTIVE: Aripiprazole lauroxil (AL) is a long-acting injectable atypical antipsychotic that was evaluated for the treatment of schizophrenia in a randomized, placebo-controlled, Phase 3 study. Here, we present exploratory analyses of supportive efficacy endpoints. METHODS: Patients experiencing an acute exacerbation of schizophrenia received AL 441 mg intramuscularly (IM), AL 882 mg IM, or matching placebo IM monthly. Supportive endpoints included changes from baseline at subsequent time points in Clinical Global Impression-Severity (CGI-S) scale score; Positive and Negative Syndrome Scale (PANSS) Total score; PANSS Positive, Negative, and General Psychopathology subscale scores; PANSS Marder factors (post hoc); and PANSS responder rate...
June 19, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28625201/a-perspective-on-the-editorial-by-ken-gillman-much-ado-about-nothing-monoamine-oxidase-inhibitors-drug-interactions-and-dietary-tyramine
#11
https://www.readbyqxmd.com/read/28535835/a-biopsychosocial-evaluation-of-the-risk-for-suicide-in-schizophrenia
#12
Nuwan C Hettige, Ali Bani-Fatemi, Isaac Sakinofsky, Vincenzo De Luca
The risk of suicide is greatly increased in individuals with schizophrenia. Previous research has identified several potential risk factors for suicidal behavior in schizophrenia, although their ability to independently predict suicide is limited. The objective of this review was to systematically analyze and identify the interaction between the proposed risk factors in the literature that may predict suicidal behavior in schizophrenia. Articles that explored suicidal behavior and suicide risk in schizophrenia that were published between 1980 and August of 2015, indexed in PubMed, MEDLINE, and Scopus were systematically reviewed...
May 24, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28758887/dazzled-by-the-dominions-of-dopamine-clinical-roles-of-d3-d2-and-d1-receptors
#13
Stephen M Stahl
Unravelling the mystery of dopamine neurotransmission, especially at its 3 most clinically relevant receptors, D3, D2, and D1, helps explain the pathophysiology of numerous psychiatric and neurologic symptoms in various CNS disorders that are theoretically caused by dysregulation of this neurotransmitter.
August 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28571592/hyperkinesia-in-ancient-china-perspectives-and-prescriptions
#14
Jia Liu, Lu-Ning Wang
No abstract text is available yet for this article.
June 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28376938/does-treating-hearing-loss-prevent-or-slow-the-progress-of-dementia-hearing-is-not-all-in-the-ears-but-who-s-listening
#15
Stephen M Stahl
Since hearing loss is strongly linked to cognitive decline, treating hearing impairment may have the potential to prevent the onset or slow the progress of dementia.
June 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28065178/investigating-the-role-of-anticipatory-reward-and-habit-strength-in-obsessive-compulsive-disorder
#16
Gabriela M Ferreira, Murat Yücel, Andrew Dawson, Valentina Lorenzetti, Leonardo F Fontenelle
Aims To determine the rates and associated illness characteristics of obsessive-compulsive disorder (OCD) patients who describe their symptoms as either rewarding or habitual. METHODS: Seventy-three treatment-seeking OCD patients had their dominant compulsive behavior assessed with a structured interview (the Temporal Impulsive-Compulsive Scale-Revised) to track the progression of rewarding (ie, gain in positive affect), aversive (ie, decrease in negative affect), and neutral (or non-affective) states and a self-report scale (the Self-Report Habit Index) to evaluate their habitual features...
June 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28031054/decreased-lymphocyte-dopamine-transporter-in-romantic-lovers
#17
Donatella Marazziti, Stefano Baroni, Gino Giannaccini, Armando Piccinni, Federico Mucci, Mario Catena-Dell'Osso, Grazia Rutigliano, Gabriele Massimetti, Liliana Dell'Osso
OBJECTIVE: The role of dopamine (DA) in romantic love is suggested by different evidence and is supported by the findings of some brain imaging studies. The DA transporter (DAT) is a key structure in regulating the concentration of the neurotransmitter in the synaptic cleft. Given the presence of DAT in blood cells, the present study aimed to explore it in resting lymphocytes of 30 healthy subjects of both sexes in the early stage of romantic love (no longer than 6 months), as compared with 30 subjects involved in a long-lasting relationship...
June 2017: CNS Spectrums
https://www.readbyqxmd.com/read/27866497/neurodevelopmental-outcomes-in-infants-exposed-in-utero-to-antipsychotics-a-systematic-review-of-published-data
#18
Salvatore Gentile, Maria Luigia Fusco
The proportion of pregnancies exposed to either second-generation antipsychotics (SGAs) or first-generation antipsychotics (FGAs) varies between 0.3%-2% of all pregnancies, but, until now, little is known about the potential neurobehavioral teratogenicity of antipsychotics. Assessing this safety facet is the aim of this article. PubMed, Scopus, and Google Scholar were searched for eligible articles. PubMed (1954 to May 2016) was searched using several medical subject headings, variously combined. PubMed search results were also limited using the search filter for human studies published in English...
June 2017: CNS Spectrums
https://www.readbyqxmd.com/read/27669819/schizo-obsessive-spectrum-disorders-an-update
#19
Estêvão Scotti-Muzzi, Osvaldo Luis Saide
The presence of obsessive-compulsive symptoms (OCS) and obsessive-compulsive disorders (OCD) in schizophrenia is frequent, and a new clinical entity has been proposed for those who show the dual diagnosis: the schizo-obsessive disorder. This review scrutinizes the literature across the main academic databases, and provides an update on different aspects of schizo-obsessive spectrum disorders, which include schizophrenia, schizotypal personality disorder (SPD) with OCD, OCD with poor insight, schizophrenia with OCS, and schizophrenia with OCD (schizo-obsessive disorder)...
June 2017: CNS Spectrums
https://www.readbyqxmd.com/read/27268576/the-medial-forebrain-bundle-as-a-target-for-deep-brain-stimulation-for-obsessive-compulsive-disorder
#20
Volker A Coenen, Thomas E Schlaepfer, Peter Goll, Peter C Reinacher, Ulrich Voderholzer, Ludger Tebartz van Elst, Horst Urbach, Tobias Freyer
Deep brain stimulation (DBS) is a promising putative modality for the treatment of refractory psychiatric disorders such as major depression and obsessive-compulsive disorder (OCD). Several targets have been posited; however, a clear consensus on differential efficacy and possible modes of action remain unclear. DBS to the supero-lateral branch of the medial forebrain bundle (slMFB) has recently been introduced for major depression (MD). Due to our experience with slMFB stimulation for MD, and because OCD might be related to similar dysfunctions of the reward system, treatment with slMFB DBS seams meaningful...
June 2017: CNS Spectrums
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