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Journal of Neural Transmission

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https://www.readbyqxmd.com/read/28920185/motivational-wheel-running-reverses-cueing-behavioural-inflexibility-in-rodents
#1
Taylor Chomiak, Andrew R Brown, G Campbell Teskey, Bin Hu
Behavioural inflexibility and associated atypical learning behaviours are common clinical manifestations of the autism spectrum disorder (ASD) phenotype. Despite advances in our understanding of ASD, little research has been devoted to experimental interventions that might help to circumvent behavioural inflexibility in ASD. The current paper suggests that motivational locomotion in the form of wheel running can reduce behavioural inflexibility and learning impairments in an ASD rat model, and discusses how the strategy of reward-coupled locomotor activity may lead to clinical interventions for children with ASD...
September 18, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28894968/lysosomal-defects-in-atp13a2-and-gba-associated-familial-parkinson-s-disease
#2
Shigeto Sato, Yuanzhe Li, Nobutaka Hattori
Genes encoding lysosomal proteins, such as ATP13A2 and GBA, are associated with familial Parkinson's disease (PD). Heterozygous mutations in GBA are strongly associated with familial PD. ATP13A2, which encodes a lysosomal P-type ATPase, has been identified as the causative gene for Kufor-Rakeb syndrome. While lysosomal dysfunction due to these mutations exhibited early onset Parkinsonism, each animal model demonstrated different pathological mechanisms. Clinicogenetic and animal model studies recently identified several lysosomal alterations that play a role in the pathogenesis of PD...
September 11, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28887651/a-cell-culture-model-for-investigation-of-synapse-influenceability-epigenetics-expression-and-function-of-gene-targets-important-for-synapse-formation-and-preservation-in-sh-sy5y-neuroblastoma-cells-differentiated-by-retinoic-acid
#3
Kirsten Jahn, C Wieltsch, N Blumer, M Mehlich, H Pathak, A Q Khan, H Hildebrandt, H Frieling
SH-SY5Y neuroblastoma cells are frequently used for different neuronal cell culture models. As there is no "gold-standard", miscellaneous protocols exist to differentiate these cells into a neuronal cell type. Here, the aim was to find a differentiation condition making cells suitable for investigation of influenceability of synapses by environmental conditions in pharmacologic experiments. For this purpose, effects on synapse molecules should be somehow rateable and cells should be usable for functional analysis like calcium imaging...
September 8, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28866757/levels-of-amyloid-beta-42-and-csf-pressure-are-directly-related-in-patients-with-alzheimer-s-disease
#4
Tommaso Schirinzi, Giulia Di Lazzaro, Giulia Maria Sancesario, Vito Luigi Colona, Eugenia Scaricamazza, Nicola Biagio Mercuri, Alessandro Martorana, Giuseppe Sancesario
Experimental data suggest that the cerebrospinal fluid (CSF) dynamic is involved in the clearance of beta-amyloid, a key event in the pathogenesis of Alzheimer's disease (AD). At this regard no evidence still exists in vivo. In this study we explored the relationships between CSF pressure and AD pathology, as measured with CSF core biomarkers. We enrolled 16 patients with probable AD and 21 controls, collecting demographics, clinical data, CSF opening pressure and CSF levels of beta-amyloid-42 fragment (Aβ42), total-tau (t-tau), phosphorylated-tau-181 (p-tau), albumin and albumin ratio...
September 2, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28864864/the-anticancer-estrogen-receptor-antagonist-tamoxifen-impairs-consolidation-of-inhibitory-avoidance-memory-through-estrogen-receptor-alpha
#5
Martina Lichtenfels, Arethuza da Silva Dornelles, Fernanda Dos Santos Petry, Martina Blank, Caroline Brunetto de Farias, Rafael Roesler, Gilberto Schwartsmann
Over two-thirds of women with breast cancer have positive tumors for hormone receptors, and these patients undergo treatment with endocrine therapy, tamoxifen being the most widely used agent. Despite being very effective in breast cancer treatment, tamoxifen is associated with side effects that include cognitive impairments. However, the specific aspects and mechanisms underlying these impairments remain to be characterized. Here, we have investigated the effects of tamoxifen and interaction with estrogen receptors on formation of memory for inhibitory avoidance conditioning in female rats...
September 2, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28865043/cerebrospinal-fluid-injection-into-adult-zebrafish-for-disease-research
#6
Hideaki Matsui, Noriko Matsui
A modified method of cerebrospinal fluid injection was developed for the efficient and reliable administration of substances to the zebrafish central nervous system. The accuracy of this modified method was evaluated using Alexa Fluor dye injection. A high survival ratio was achieved due to the simplicity of the procedure and ice-tricaine combined anaesthesia. To validate this new method, we injected ammonium chloride, which successfully blocked lysosome function resulting in elevated LC3-II and the accumulation of ubiquitinated proteins...
September 1, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28864916/effects-of-transcranial-direct-current-stimulation-on-the-auditory-mismatch-negativity-response-and-working-memory-performance-in-schizophrenia-a-pilot-study
#7
Danielle Impey, Ashley Baddeley, Renee Nelson, Alain Labelle, Verner Knott
Cognitive impairment has been proposed to be the core feature of schizophrenia (Sz). Transcranial direct current stimulation (tDCS) is a non-invasive form of brain stimulation which can improve cognitive function in healthy participants and in psychiatric patients with cognitive deficits. tDCS has been shown to improve cognition and hallucination symptoms in Sz, a disorder also associated with marked sensory processing deficits. Recent findings in healthy controls demonstrate that anodal tDCS increases auditory deviance detection, as measured by the brain-based event-related potential, mismatch negativity (MMN), which is a putative biomarker of Sz that has been proposed as a target for treatment of Sz cognition...
September 1, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28864907/alterations-in-the-reduced-pteridine-contents-in-the-cerebrospinal-fluids-of-lrrk2-mutation-carriers-and-patients-with-parkinson-s-disease
#8
Hiroshi Ichinose, Ken-Ichi Inoue, Shinobu Arakawa, Yuki Watanabe, Hiroki Kurosaki, Shoko Koshiba, Eldbjorg Hustad, Masahiko Takada, Jan O Aasly
Tetrahydrobiopterin (BH4) is a cofactor for tyrosine hydroxylase that is essential for the biosynthesis of dopamine. Parkinson's disease (PD) is characterized by a progressive degeneration of nigrostriatal dopaminergic neurons, and biomarkers reflecting the degree of neurodegeneration are important not only for basic research but also for clinical diagnosis and the treatment of the disease. Although the total neopterin and biopterin levels in the cerebrospinal fluids (CSF) of the patients with PD were reported, alterations in the composition of reduced and oxidized forms of pteridine compounds have not been examined...
September 1, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28864885/a-systematic-meta-analysis-of-the-association-of-neuregulin-1-nrg1-d-amino-acid-oxidase-dao-and-dao-activator-daoa-g72-polymorphisms-with-schizophrenia
#9
Vinita Jagannath, Miriam Gerstenberg, Christoph U Correll, Susanne Walitza, Edna Grünblatt
The glutamate hypothesis of schizophrenia is related to the proposed dysregulation of D-amino acid oxidase (DAO), DAO activator (DAOA)/G72, and Neuregulin 1 (NRG1) genes. Genetic studies have shown significant associations between DAO, DAOA, NRG1 single-nucleotide polymorphisms (SNPs), and schizophrenia. The systematic literature search yielded 6, 5, and 18 new studies for DAO, DAOA, and NRG1 published after 2011 and not included in the previous SchizophreniaGene (SZGene) meta-analysis. We conducted meta-analyses of 20, 23, and 48 case-control studies, respectively, to comprehensively evaluate the association of 8 DAO, 12 DAOA, and 14 NRG1 SNPs with schizophrenia...
September 1, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28864837/near-infrared-spectroscopy-nirs-and-vagus-somatosensory-evoked-potentials-vsep-in-the-early-diagnosis-of-alzheimer-s-disease-rationale-design-methods-and-first-baseline-data-of-the-vogel-study
#10
Thomas Polak, Martin J Herrmann, Laura D Müller, Julia B M Zeller, Andrea Katzorke, Matthias Fischer, Fabian Spielmann, Erik Weinmann, Leif Hommers, Martin Lauer, Andreas J Fallgatter, Jürgen Deckert
Functional near-infrared spectroscopy (fNIRS) and vagus somatosensory evoked potentials (VSEP) show deviant patterns in subjects with Alzheimer's disease (AD) compared to healthy controls. We now aimed at testing the predictive value of these methods in the early diagnosis of AD. The Vogel study is a prospective, observational, long-term follow-up study with three time points of investigation within 6 years. Residents of the city of Würzburg born between 1936 and 1941 were recruited. Every participant underwent physical, psychiatric, and laboratory examinations, and performed an intense neuropsychological testing as well as VSEP and NIRS according to the published procedures...
September 1, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28861737/chronic-mptp-administration-regimen-in-monkeys-a-model-of-dopaminergic-and-non-dopaminergic-cell-loss-in-parkinson-s-disease
#11
REVIEW
Gunasingh J Masilamoni, Yoland Smith
Parkinson's disease (PD) is a progressive neurodegenerative disorder clinically characterized by cardinal motor deficits including bradykinesia, tremor, rigidity and postural instability. Over the past decades, it has become clear that PD symptoms extend far beyond motor signs to include cognitive, autonomic and psychiatric impairments, most likely resulting from cortical and subcortical lesions of non-dopaminergic systems. In addition to nigrostriatal dopaminergic degeneration, pathological examination of PD brains, indeed, reveals widespread distribution of intracytoplasmic inclusions (Lewy bodies) and death of non-dopaminergic neurons in the brainstem and thalamus...
August 31, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28836067/is-nigrostriatal-dopaminergic-deficit-necessary-for-holmes-tremor-to-develop-the-datscan-and-ibzm-spect-study
#12
Agata Gajos, Sławomir Budrewicz, Magdalena Koszewicz, Małgorzata Bieńkiewicz, Janusz Dąbrowski, Jacek Kuśmierek, Jarosław Sławek, Andrzej Bogucki
Holmes's tremor (HT) is assumed to be the result of coexistence of nigrostriatal dopaminergic system impairment and the lesion of cerebello-thalamic pathways. It was suggested that dopaminergic deficiency is responsible for rest tremor, and lack of compensatory cerebellar function leads to spill of tremor into voluntary movements. Cases of HT with and without abnormalities of the presynaptic part of dopaminergic nigrostriatal were published and these findings raised the question of possibility of the postsynaptic lesion...
August 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28828495/abstracts-of-the-wasad-conference-2017-14-16-september-w%C3%A3-rzburg-germany
#13
(no author information available yet)
No abstract text is available yet for this article.
August 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28821967/effects-of-oxytocin-and-arginine-vasopressin-on-the-proliferation-and-differentiation-of-a-serotonergic-cell-line
#14
Zoya Marinova, Susanne Walitza, Edna Grünblatt
The neuropeptides oxytocin and arginine vasopressin (AVP) are involved in the regulation of social behavior and cognition. The current study analyzed the effect of oxytocin and AVP on proliferation and differentiation of serotonergic neurons (RN46A cells). Oxytocin did not affect, while 5-10 μM AVP decreased RN46A proliferation. Oxytocin did not significantly alter, while 10 μM AVP decreased the number of cells extending neurites. We found divergent effects of oxytocin and AVP in serotonergic neurons, underscoring their functional differences...
August 18, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28815330/homer1a-protein-expression-in-schizophrenia-bipolar-disorder-and-major-depression
#15
Stefan L Leber, Ida C Llenos, Christine L Miller, Jeannette R Dulay, Johannes Haybaeck, Serge Weis
In recent years, there was growing interest in postsynaptic density proteins in the central nervous system. Of the most important candidates of this specialized region are proteins belonging to the Homer protein family. This family of scaffolding proteins is suspected to participate in the pathogenesis of a variety of diseases. The present study aims to compare Homer1a expression in the hippocampus and cingulate gyrus of patients with major psychiatric disorders including schizophrenia, bipolar disorder and major depression...
August 16, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28803382/cortical-afferent-inhibition-abnormalities-reveal-cholinergic-dysfunction-in-parkinson-s-disease-a-reappraisal
#16
REVIEW
Raffaele Nardone, Francesco Brigo, Viviana Versace, Yvonne Höller, Frediano Tezzon, Leopold Saltuari, Eugen Trinka, Luca Sebastianelli
Parkinson's disease (PD) is a multisystem neurodegenerative disorder affecting, besides the dopaminergic function, multiple neurotransmission systems, including the cholinergic system. Central cholinergic circuits of human brain can be tested non-invasively by coupling peripheral nerve stimulation with transcranial magnetic stimulation (TMS) of motor cortex; this test is named short latency afferent inhibition (SAI). SAI abnormalities have been reported in PD patients with gait disturbances and many non-motor symptoms, such as visual hallucinations (VHs), REM sleep behavior disorder (RBD), dysphagia, and olfactory impairment...
August 12, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28795276/topiramate-via-nmda-ampa-kainate-gabaa-and-alpha2-receptors-and-by-modulation-of-creb-bdnf-and-akt-gsk3-signaling-pathway-exerts-neuroprotective-effects-against-methylphenidate-induced-neurotoxicity-in-rats
#17
Majid Motaghinejad, Manijeh Motevalian, Sulail Fatima, Tabassom Beiranvand, Shiva Mozaffari
Chronic abuse of methylphenidate (MPH) often causes neuronal cell death. Topiramate (TPM) carries neuroprotective effects, but its exact mechanism of action remains unclear. In the present study, the role of various doses of TPM and its possible mechanisms, receptors and signaling pathways involved against MPH-induced hippocampal neurodegeneration were evaluated in vivo. Thus, domoic acid (DOM) was used as AMPA/kainate receptor agonist, bicuculline (BIC) as GABAA receptor antagonist, ketamine (KET) as NMDA receptor antagonist, yohimbine (YOH) as α2 adrenergic receptor antagonist and haloperidol (HAL) was used as dopamine D2 receptor antagonist...
August 9, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28785851/erratum-to-effects-of-methylphenidate-on-attention-in-wistar-rats-treated-with-the-neurotoxin-n-2-chloroethyl-n-ethyl-2-bromobenzylamine-dsp4
#18
Joachim Hauser, Andreas Reissmann, Thomas-A Sontag, Oliver Tucha, Klaus W Lange
No abstract text is available yet for this article.
August 7, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28770390/genome-wide-significant-replicated-and-functional-risk-variants-for-alzheimer-s-disease
#19
Xiaoyun Guo, Wenying Qiu, Rolando Garcia-Milian, Xiandong Lin, Yong Zhang, Yuping Cao, Yunlong Tan, Zhiren Wang, Jing Shi, Jijun Wang, Dengtang Liu, Lisheng Song, Yifeng Xu, Xiaoping Wang, Na Liu, Tao Sun, Jianming Zheng, Justine Luo, Huihao Zhang, Jianying Xu, Longli Kang, Chao Ma, Kesheng Wang, Xingguang Luo
Genome-wide association studies (GWASs) have reported numerous associations between risk variants and Alzheimer's disease (AD). However, these associations do not necessarily indicate a causal relationship. If the risk variants can be demonstrated to be biologically functional, the possibility of a causal relationship would be increased. In this article, we reviewed all of the published GWASs to extract the genome-wide significant (p < 5×10(-8)) and replicated associations between risk variants and AD or AD-biomarkers...
August 2, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28770389/long-term-stability-of-reconstituted-incobotulinumtoxina-how-can-we-reduce-costs-of-botulinum-toxin-therapy
#20
Dirk Dressler, Hans Bigalke
Botulinum neurotoxin (BNT), the biologically active component of botulinum toxin (BT), is a large double-stranded protein susceptible to various physical and chemical influences. All BT type A (BT-A) drugs are stored as powders allowing shelf lives from 24 to 36 months. After reconstitution, the specified shelf life is reduced to 8-24 h. Some studies, however, suggest longer shelf life. We wanted to test the long-term stability of reconstituted BT-A drugs in the hemidiaphragm assay (HDA), a high quality BT potency test...
August 2, 2017: Journal of Neural Transmission
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