journal
MENU ▼
Read by QxMD icon Read
search

Journal of Neural Transmission

journal
https://www.readbyqxmd.com/read/29748850/from-aggression-to-autism-new-perspectives-on-the-behavioral-sequelae-of-monoamine-oxidase-deficiency
#1
REVIEW
Marco Bortolato, Gabriele Floris, Jean C Shih
The two monoamine oxidase (MAO) enzymes, A and B, catalyze the metabolism of monoamine neurotransmitters, such as serotonin, norepinephrine, and dopamine. The phenotypic outcomes of MAO congenital deficiency have been studied in humans and animal models, to explore the role of these enzymes in behavioral regulation. The clinical condition caused by MAOA deficiency, Brunner syndrome, was first described as a disorder characterized by overt antisocial and aggressive conduct. Building on this discovery, subsequent studies were focused on the characterization of the role of MAOA in the neurobiology of antisocial conduct...
May 10, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29748849/correlations-between-abnormal-iron-metabolism-and-non-motor-symptoms-in-parkinson-s-disease
#2
Wu Xu, Yan Zhi, Yongsheng Yuan, Bingfeng Zhang, Yuting Shen, Hui Zhang, Kezhong Zhang, Yun Xu
Despite a growing body of evidence suggests that abnormal iron metabolism plays an important role in the pathogenesis of Parkinson's disease (PD), few studies explored its role in non-motor symptoms (NMS) of PD. The present study aimed to investigate the relationship between abnormal iron metabolism and NMS of PD. Seventy PD patients and 64 healthy controls were consecutively recruited to compare serum iron, ceruloplasmin, ferritin, and transferrin levels. We evaluated five classic NMS, including depression, anxiety, pain, sleep disorder, and autonomic dysfunction in PD patients using the Hamilton Depression Scale (HAMD), the Hamilton Anxiety Scale (HAMA), the short form of the McGill Pain Questionnaire, the Pittsburgh Sleep Quality Index and the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms, respectively...
May 10, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29728861/patient-characteristics-driving-clinical-utility-in-psychiatric-pharmacogenetics-a-reanalysis-from-the-ab-gen-multicentric-trial
#3
J M Menchón, J Espadaler, M Tuson, J Saiz-Ruiz, J Bobes, E Vieta, E Álvarez, V Pérez
Clinical utility of commercial multi-gene pharmacogenetic tests in depression is starting to be studied with some promising results on efficacy and tolerability. Among the next steps is the definition of the patient profile that is most likely to benefit from testing. Here we present a reanalysis of data from the AB-GEN randomized clinical trial showing that clinical utility of pharmacogenetic testing can be markedly influenced by patient characteristics such as age, baseline severity and duration of current depressive episode...
May 4, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29713806/an-inducible-mao-b-mouse-model-of-parkinson-s-disease-a-tool-towards-better-understanding-basic-disease-mechanisms-and-developing-novel-therapeutics
#4
REVIEW
Manish Chamoli, Shankar J Chinta, Julie K Andersen
Several studies have suggested that increases in astrocytic monoamine oxidase B (MAO-B) levels in conjunction with Parkinson's disease (PD) may contribute to subsequent neuropathology associated with the disorder. MAO-B inhibitors are currently widely used as symptomatic therapeutics for PD and, although somewhat controversial, these drugs may also exhibit disease-modifying properties. To obtain a better understanding of the potential role of MAO-B in disease neuropathology, we created an inducible astrocyte-specific transgenic MAO-B mouse model...
April 30, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29704061/on-the-neuronal-circuitry-mediating-l-dopa-induced-dyskinesia
#5
REVIEW
M Angela Cenci, Henrik Jörntell, Per Petersson
With the advent of rodent models of L-DOPA-induced dyskinesia (LID), a growing literature has linked molecular changes in the striatum to the development and expression of abnormal involuntary movements. Changes in information processing at the striatal level are assumed to impact on the activity of downstream basal ganglia nuclei, which in turn influence brain-wide networks, but very little is actually known about systems-level mechanisms of dyskinesia. As an aid to approach this topic, we here review the anatomical and physiological organisation of cortico-basal ganglia-thalamocortical circuits, and the changes affecting these circuits in animal models of parkinsonism and LID...
April 27, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29700607/cerebrovascular-inflammation-is-associated-with-tau-pathology-in-guam-parkinsonism-dementia
#6
Petra Majerova, Ralph M Garruto, Andrej Kovac
Parkinsonism-dementia complex of Guam (Guam PDC) is a neurodegenerative disease with parkinsonism and early onset Alzheimer-like dementia. Guam PDC belongs to the family of neurodegenerative disorders, known as tauopathies, which are histopathologically characterized by abnormal deposition of microtubule-associated protein tau. While changes in the blood-brain barrier (BBB) in Alzheimer's disease are increasingly recognized, dysfunction of BBB in Guam PDC has not been extensively studied. In this study, we characterized cerebrovascular changes in the patients with Guam PDC...
April 26, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29644397/coq2-variants-in-parkinson-s-disease-and-multiple-system-atrophy
#7
Michitaka Mikasa, Kazuaki Kanai, Yuanzhe Li, Hiroyo Yoshino, Kaoru Mogushi, Arisa Hayashida, Aya Ikeda, Sumihiro Kawajiri, Yasuyuki Okuma, Kenichi Kashihara, Tatsuya Sato, Hiroshi Kondo, Manabu Funayama, Kenya Nishioka, Nobutaka Hattori
Coenzyme Q2, polyprenyltransferase (COQ2) variants have been reported to be associated with multiple system atrophy (MSA). However, the relationship between COQ2 variants and familial Parkinson's disease (PD) remains unclear. We investigated the frequency of COQ2 variants and clinical symptoms among familial PD and MSA. We screened COQ2 using the Sanger method in 123 patients with familial PD, 52 patients with sporadic PD, and 39 patients with clinically diagnosed MSA. Clinical information was collected from medical records for the patients with COQ2 variants...
April 11, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29644396/correction-to-pupillometry-as-an-indicator-of-l-dopa-dosages-in-parkinson-s-disease-patients
#8
O Bartošová, C Bonnet, O Ulmanová, M Šíma, F Perlík, E Růžička, O Slanař
Unfortunately, original article has been published without acknowledgement section.
April 11, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29637260/90-years-of-monoamine-oxidase-some-progress-and-some-confusion
#9
REVIEW
Keith F Tipton
It would not be practical to attempt to deal with all the advances that have informed our understanding of the behavior and functions of this enzyme over the past 90 years. This account concentrates key advances that explain why the monoamine oxidases remain of pharmacological and biochemical interest and on some areas of continuing uncertainty. Some issues that remain to be understood or are in need of further clarification are highlighted.
April 10, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29626260/clinical-utility-of-pharmacogenetic-testing-in-children-and-adolescents-with-severe-mental-disorders
#10
Hilario Blasco-Fontecilla
This is a retrospective cohort study of 20 children and adolescents to evaluate the clinical utility of a pharmacogenetic decision support tool. Twenty children and adolescents underwent pharmacogenetic testing between June 2014 and May 2017. All children and adolescents were evaluated at Puerta de Hierro University Hospital-Majadahonda (Madrid, Spain). We report the proportion of patients achieving clinical improvement, amelioration of side effects, and changes in number of drugs. Data normality was assessed with the Shapiro-Wilk test, and changes of pre- and post-pharmacogenetic testing were analyzed with the Wilcoxon test for paired samples...
April 6, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29623427/neuroinflammation-in-neurodegeneration-role-in-pathophysiology-therapeutic-opportunities-and-clinical-perspectives
#11
EDITORIAL
Guillaume Dorothée
No abstract text is available yet for this article.
April 6, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29616335/behavioral-mechanisms-underlying-the-maternal-disruptive-effect-of-serotonin-5-ht-2a-receptor-activation-in-sprague-dawley-rats
#12
Ruiyong Wu, Collin Davis, Ming Li
Recent evidence indicates that acute activation of 5-HT2A receptors causes a disruption of maternal behavior in rats. However, the behavioral mechanisms underlying such a disruption are not known. We addressed this issue using two behavioral approaches targeting the maternal motivational and emotional processing systems. First, we used the pup-separation technique to increase maternal motivation to see whether pup separation is capable of reducing the maternal disruptive effect of TCB-2 (a high-affinity 5-HT2A agonist) treatment...
April 3, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29600412/associations-of-monoamine-oxidase-a-gene-first-exon-methylation-with-sexual-abuse-and-current-depression-in-women
#13
David Checknita, Tomas J Ekström, Erika Comasco, Kent W Nilsson, Jari Tiihonen, Sheilagh Hodgins
Childhood physical abuse (PA) and sexual abuse (SA) interact with monoamine oxidase A (MAOA) gene polymorphism to modify risk for mental disorders. In addition, PA and SA may alter gene activity through epigenetic mechanisms such as DNA methylation, thereby further modifying risk for disorders. We investigated whether methylation in a region spanning the MAOA first exon and part of the first intron was associated with PA and/or SA, MAOA genotype, alcohol dependence, drug dependence, depression disorders, anxiety disorders, and conduct disorder...
March 29, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29582150/evaluation-of-artifact-corrected-electroencephalographic-eeg-training-a-pilot-study
#14
Jeffry P La Marca, Daniel Cruz, Jennifer Fandino, Fabiana R Cacciaguerra, Joseph J Fresco, Austin T Guerra
This double-blind study examined the effect of electromyographical (EMG) artifacts, which contaminate electroencephalographical (EEG) signals, by comparing artifact-corrected (AC) and non-artifact-corrected (NAC) neurofeedback (NF) training procedures. 14 unmedicated college students were randomly assigned to two groups: AC (n = 7) or NAC (n = 7). Both groups received 12 sessions of NF and were trained using identical NF treatment protocols to reduce their theta/beta power ratios (TBPR). Outcomes on a continuous performance test revealed that the AC group had statistically significant increases across measures of auditory and visual attention...
March 26, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29569037/monoamine-oxidase-b-inhibitors-in-the-treatment-of-parkinson-s-disease-clinical-pharmacological-aspects
#15
REVIEW
Peter Riederer, Thomas Müller
This invited narrative review emphasizes the role of MAO-B inhibition in the drug portfolio for dopamine substitution in patients with Parkinson's disease. Neuronal and glial MAO-B inhibition contributes to more stable levels of dopamine and other biogenic amines in the synaptic cleft. Accordingly, symptomatic effects of MAO-B inhibition for a limited amelioration of impaired motor behaviour and wearing-off phenomena in patients with Parkinson's disease are well proven, even when MAO-B inhibitors are only applied together with dopamine agonists...
March 22, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29541852/neuroinflammation-in-l-dopa-induced-dyskinesia-beyond-the-immune-function
#16
REVIEW
Augusta Pisanu, Laura Boi, Giovanna Mulas, Saturnino Spiga, Sandro Fenu, Anna R Carta
Neuroinflammation is a main component of Parkinson's disease (PD) neuropathology, where unremitting reactive microglia and microglia-secreted soluble molecules such as cytokines, contribute to the neurodegenerative process as part of an aberrant immune reaction. Besides, pro-inflammatory cytokines, predominantly TNF-α, play an important neuromodulatory role in the healthy and diseased brain, being involved in neurotransmitter metabolism, synaptic scaling and brain plasticity. Recent preclinical studies have evidenced an exacerbated neuroinflammatory reaction in the striatum of parkinsonian rats that developed dyskinetic responses following L-DOPA administration...
March 14, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29520614/attentional-functioning-in-individuals-with-22q11-deletion-syndrome-insight-from-erps
#17
Daniela Mannarelli, Caterina Pauletti, Tommaso Accinni, Luca Carlone, Marianna Frascarelli, Guido Maria Lattanzi, Antonio Currà, Francesco Fattapposta
The 22q11 deletion syndrome (22q11DS), or DiGeorge syndrome (DG), is one of the most common genetic deletion syndromes. DG also carries a high risk for psychiatric disorders, with learning disabilities frequently being reported. Impairments in specific cognitive domains, such as executive functioning and attention, have also been described. The aim of this study was to investigate attentional functioning in a group of subjects with DG using ERPs, and in particular the P300 and CNV components. We studied ten patients with DG and ten healthy subjects that performed a P300 Novelty task and a CNV motor task...
March 8, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29520613/in-vivo-exploration-of-retinal-nerve-fiber-layer-morphology-in-parkinson-s-disease-patients
#18
Femke Visser, Koenraad A Vermeer, Babak Ghafaryasl, Annemarie M M Vlaar, Valentin Apostolov, Jan van Hellenberg Hubar, Henry C Weinstein, Johannes F de Boer, Henk W Berendse
Thinning of the retinal nerve fiber layer (RNFL) is a recently discovered feature of Parkinson's disease (PD). Its exact pathological mechanism is yet unknown. We aimed to determine whether morphological changes of the RNFL are limited to RNFL thinning or also comprise an altered internal structure of this layer. Therefore, we investigated RNFL thickness and applied the RNFL attenuation coefficient (RNFL-AC), a novel method derived from optical coherence tomography, in PD patients and healthy controls (HCs)...
March 8, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29516165/kinetics-mechanism-and-inhibition-of-monoamine-oxidase
#19
REVIEW
Rona R Ramsay, Alen Albreht
Monoamine oxidases (MAOs) catalyse the oxidation of neurotransmitter amines and a wide variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs. While inhibition of MAO activity in the periphery removes protection from biogenic amines and so is undesirable, inhibition in the brain gives vital antidepressant and behavioural advantages that make MAO a major pharmaceutical target for inhibitor design. In neurodegenerative diseases, MAO inhibitors can help to maintain neurotransmitter levels, making it a common feature in novel multi-target combinations designed to combat Alzheimer's disease, albeit not yet proven clinically...
March 7, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29511827/impulse-control-disorders-in-parkinson-s-disease
#20
REVIEW
Ana Marques, Franck Durif, Pierre-Olivier Fernagut
Impulse control disorders (ICD) are frequent side effects of dopamine replacement therapy (DRT) used in Parkinson's disease (PD) with devastating consequences on the patients and caregivers. ICD are behavioural addictions including compulsive gambling, shopping, sexual behaviour, and binge eating that are mainly associated with dopamine D2/D3 agonists. Their management is a real clinical challenge due to the lack of therapeutic alternative. Clinical studies have identified demographic and clinical risk factors for ICD such as younger age at disease onset, male gender, prior history of depression or substance abuse, REM sleep behaviour disorders and higher rate of dyskinesia...
March 7, 2018: Journal of Neural Transmission
journal
journal
32684
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"