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Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association

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https://www.readbyqxmd.com/read/27008827/-some-case-reports-which-suggest-correlation-between-biologics-and-leprosy-mini-symposium-on-problems-on-leprosy
#1
Yutaka Ishida
Biologics are relatively new drugs developed through modern monoclonal antibody techniques and became more familiar to some disease treatments such as Rheumatoid arthritis, psoriasis, ankylosing spondylitis, ulcerative colitis, malignant lymphoma, SLE and lupus nephritis. Some case reports shows development of leprosy during/after biolo- gics treatment and success treatment of ENL with biologics. Collection of reports was done through web search by using document retrieval engine such as Pub-med and ProQuest...
January 2016: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/27008826/-hearing-loss-in-leprosarium-current-status
#2
Reiri Kosugiyama, Norio Kasai, Tsutomu Etani, Akio Oshima
Due to aging and aftereffects of leprosy, many of them are now struggling with hearing loss and visual impairment. The purpose of this study was to investigate and analyze the present situation of hearing level and hearing aid among residents in leprosy sanatorium. We have been carrying out hearing screening for the all ex-patients in three national sanatoriums, Nagashima-Aisein (since 2011), Oku-Komyo-en (since 2012), and Matsuoka-Hoyo-en (since 2014). The results of audiometry and questionnaire in 2014 were analyzed...
January 2016: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/27008825/-the-originality-and-creativity-of-leprosy-sequelae-patients-in-regard-to-dental-care
#3
Masatsugu Nakagawa, Akemi Shimizu
Leprosy sequelae patients surmount the inconvenience by the handicap. When people with the handicap are able to do the same act as healthy people, we may not pay attention to the originality and creativity for it. Therefore, we are not able to notice some risks which are hidden. We turned our attention to the denture in the oral region. The methods of putting in and taking out the denture of leprosy sequelae patients are characteristic. Even a partial denture, there are many patients who take out their denture using only their tongue, without touching a clasp with a finger...
January 2016: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/27008823/-in-memory-of-dr-joon-lew
#4
G T Chae
No abstract text is available yet for this article.
January 2016: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/27008821/-foreword
#5
M Matsuoka
No abstract text is available yet for this article.
January 2016: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/26630800/50-years-on-the-united-states-japan-cooperative-medical-science-program-1965-2015-part-ii-the-leprosy-joint-panel
#6
Patrick J Brennan
No abstract text is available yet for this article.
September 2015: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/26630799/-the-present-conditions-and-future-of-national-sanatorium-kikuchi-keifuen
#7
Reiko Nogami
National Sanatorium Kikuchi Keifuen (NSKK), housing 286 residents as of May 2015, is one of the biggest and oldest Hansen's disease sanatoriums in Japan. Located near the center of Kumamoto city, NSKK has maintained an excellent working relationship with Kumamoto University along with other neighboring medical institutions over the years. However, despite its advantages in standing, it may suffer the same problems as other sanatoriums: continually declining numbers of residents combined with the increasing frailty and dementia of existing residents due to aging and an increasing difficulty in maintaining a competent medical staff into the future...
September 2015: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/26630798/-on-the-present-and-future-of-national-sanatorium-tohokushinseien
#8
T Kai
No abstract text is available yet for this article.
September 2015: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/26630797/-on-the-present-and-future-of-japanese-leprosariums-the-case-of-oshima-seishoen-sanatorium
#9
Norihisa Sano
In all thirteen national sanatorium in Japan, the number of patients have gradually declined year by year. Although it has been long discussed about maintenance and utilization of facilities in the future, clear and specific plans are still not sufficient. Especially Oshima-seishoen sanatorium, Oshima island is an isolated island located off the coast of Takamatsu port. It is very different from the other Leprosy sanatoriums in that there are no general population other than patients and officials of the sanatorium...
September 2015: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/25826852/-what-hansen-s-disease-research-learned-from-tuberculosis-research-from-molecular-biological-aspect
#10
REVIEW
Yasuhiko Suzuki, Tomoyuki Yamaguchi, Hyun Kim, Kazumasa Yokoyama, Chie Nakajima
As for the Mycobacterium leprae which is a causative agent of Hansen's disease, many studies had been done since it was identified in 1873. However, those studies, at the same time, experienced many struggles because of the difficulty of culture of M. leprae on the artificial growth media. Hence, the study of Hansen's disease progressed by taking the knowledge from the study of tuberculosis caused by the bacteria belonging to the same genus, genus Mycobacterium. For instance, the knowledge of mutations in specific genes responsible for rifampicin- and quinolone-resistance in M...
December 2014: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/25826851/-leprosy-and-human-rights-trends-in-japan-and-in-the-world
#11
Yozo Yokota
Leprosy, or Hansen's disease, has long been regarded as an incurable and dreadful contagious disease. The patients have been forcefully hospitalized and deprived of many basic human rights. Their family members have often been discriminated against due to stigma associated with this disease. Soon after the Second World War, a specific remedy called "multi-drug therapy" (MDT) was discovered and leprosy became a relatively easily curable disease. Despite this medical development, it took time to change the policy and legislation of forceful hospitalization of leprosy patients...
December 2014: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/25826850/-current-status-of-dementia-in-admitions-to-national-leprosariums-nationwide
#12
Asako Kawaguchi, Kyoko Watanabe, Tachiko Yoshimura, Kayoko Date, Kiyomi Yamashita
The purpose of this study was to get an overview of the following aspects of people admitted to 13 national leprosariums in Japan: the prevalence of dementia, medical and nursing systems, and facilities and equipment. Subjects included 1733 people admitted to wards for patients or disabled people in these leprosariums. Subjects were examined for cognitive function using Nishimura's behavioral rating scale for the mental states of the elderly (NMS), and for the prevalence of behavioral and psychological symptoms of dementia (BPSD)...
December 2014: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/25826849/-effectiveness-of-thalidomide-for-erythema-nodosum-leprosum-enl-retrospective-study-of-20-japanese-cases-in-national-sanatrium-oku-komyoen
#13
Takanobu Matsuki, Yoshiko Okano, Yoshinori Aoki, Yutaka Ishida, Kentaro Hatano, Kimiko Kumano
Thalidomide is a TNF-alpha inhibitor and has been administrated for erythema nodosum leprosum (ENL, Type II leprosy reaction) which is one of leprosy reactions and can cause serious illness to patients oflepromatous pole among the immune spectrum. Twenty live cases (at May, 2011) were identified to whom thalidomide had been administrated since 1978 for their ENL reactions. Data were collected from their clinical records in order to evaluate the usage and effectiveness of thalidomide in National Sanatorium Oku-Komyoen, Okayama, Setouchi-city, Japan...
December 2014: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/25272518/50-years-on-the-united-states-japan-cooperative-medical-science-program-1965-2015-part-1
#14
Patrick J Brennan
No abstract text is available yet for this article.
July 2014: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/25272517/-the-characteristic-of-oral-status-and-dental-treatment-of-leprosy-sequelae-patients
#15
Masatsugu Nakagawa, Akemi Shimizu
The leprosy sequelae especially the handicap of eyes and hands makes difficult to maintain the oral health status. So, leprosy sequelae patients are controlling themselves by creative and original methods. However even such efforts have hardly reached the level to stop of caries and periodontal disease. More support is required in order for them to maintain the oral health status. Therefore, in National Sanatorium Nagashima Aiseien, we started the periodic preventive system containing oral check-up, mouth cleaning, and early detection early treatment 15 years before...
July 2014: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/25076761/-review-of-who-expert-committee-on-leprosy-8th-report-comparison-to-7th-report
#16
REVIEW
Shinichi Kitajima, Junichiro En, Shiori Kitajima, Sumana Barua, Masamichi Goto
In 2012 the WHO Expert Committee on Leprosy published its 8th report, 14 years after the publication of its 7th report in 1998. This report, the first since the leprosy reduction goal was met in 2000, highlights key points such as improvements in the quality of various services available to patients and the efforts of individuals and societies, in addition to medical progress in diagnosis and treatment. This review will mainly describe the changes made since the 7th report. Some of the main modifications are the deletion of single lesion paucibacillary type, elongated treatment of patients with high bacterial indices, the introduction of promising new drugs, and a shift from reducing the statistical number of patients to a new target for disability prevention...
March 2014: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/25076760/-rapid-detection-of-mutations-related-to-mycobacterium-leprae-drug-resistance-by-using-hp-rpcr-hairpin-primer-real-time-pcr-method
#17
Masanori Kai
Rapid and simple detection method of drug resistance bacteria is required. In the present study, Hp-rPCR (hairpin primer-real time PCR) was applied to Mycobacterium leprae genes to detect mutations. Target sites of the method were as follows: first base and second base on 53rd codon and second base on 55th codon infolP1 gene for dapsone resistance, first base on 441st codon and 451st codon and second base on 456th and 458th codon in rpoB gene for rifampicin resistance, and first base on 89th codon and second base on 91st codon in gyrA gene for quinolone resistance which were common mutation sites in clinical reports...
March 2014: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/24579462/-guidelines-for-the-treatment-of-hansen-s-disease-in-japan-third-edition
#18
Masamichi Goto, Reiko Nogam, Yoshiko Okano, Masaichi Gidoh, Rie Yotsu, Yutaka Ishida, Shinichi Kitajima, Masanori Kai, Norihisa Ishii, Motoaki Ozaki, Kentaro Hatano
ad hoc committee of Japanese Leprosy Association recommends revised standard treatment protocol of leprosy in Japan, which is a modification of World Health Organization's multidrug therapy (WHO/MDT, 2010). For paucibacillary (PB) leprosy, 6 months treatment by rifampicin and dapsone (MDT/PB) is enough. However, for high bacterial load multibacillary (MB) leprosy, 12 months treatment seems insufficient. Thus, (A) For MB with bacterial index (BI) > 3 before treatment, 2 years treatment by rifampicin, dapsone and clofazimine (MDT/MB) is necessary...
December 2013: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/24579461/-present-state-of-hansen-s-disease-between-2012-and-2013-weekly-epidemiological-record-no-35-2013-88-365-380-translated-by-shuichi-mori
#19
Sumana Barua
No abstract text is available yet for this article.
December 2013: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
https://www.readbyqxmd.com/read/24579460/innate-and-acquired-immune-responses-to-mycobacterial-infections-involvement-of-il-17a-il-23-axis-in-protective-immunity
#20
REVIEW
Masayuki Umemura, Goro Matsuzaki
Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, and continues to be a serious threat to human life. Since M. tuberculosis establishes intracellular parasitism in macrophages, host innate and acquired immune systems have to detect and enhance bactericidal activity against the intracellular bacteria. Understanding of interaction between pathogenic factors of M. tuberculosis and host is also important to understand how immune system copes with the pathogen. In this review, we shortly summarize the mechanisms how innate and acquired immunity recognize M...
December 2013: Japanese Journal of Leprosy: Official Organ of the Japanese Leprosy Association
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