Naveen Kumar, Vikram Delu, Ilya Ulasov, Sanjay Kumar, Rishi Kant Singh, Sandeep Kumar, Alok Shukla, Anand Kumar Patel, Lokesh Yadav, Ruchi Tiwari, Kumari Rachana, Shivashish Priyadarshi Mohanta, Varsha Singh, Anuradha Yadav, Kaushalendra Kaushalendra, Arbind Acharya
Nucleoside analogs are a common form of chemotherapy that disrupts DNA replication and repair, leading to cell cycle arrest and apoptosis. Reactive oxygen species (ROS) production is a significant mechanism through which these drugs exert their anticancer effects. This study investigated a new nucleoside analog called FNC or Azvudine, and its impact on ROS production and cell viability in Dalton's lymphoma (DL) cells. The study found that FNC treatment resulted in a time- and dose-dependent increase in ROS levels in DL cells...
March 14, 2024: Cell Biochemistry and Biophysics