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Cell Biochemistry and Biophysics

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https://www.readbyqxmd.com/read/28434138/dynamic-epr-oximetry-of-changes-in-intracerebral-oxygen-tension-during-induced-thromboembolism
#1
Huagang Hou, Nadeem Khan, Sangeeta Gohain, Clifford J Eskey, Karen L Moodie, Kirk J Maurer, Harold M Swartz, Periannan Kuppusamy
Cerebral tissue oxygenation (oxygen tension, pO2) is a critical parameter that is closely linked to brain metabolism, function, and pathophysiology. In this work, we have used electron paramagnetic resonance oximetry with a deep-tissue multi-site oxygen-sensing probe, called implantable resonator, to monitor temporal changes in cerebral pO2 simultaneously at four sites in a rabbit model of ischemic stroke induced by embolic clot. The pO2 values in healthy brain were not significantly different among the four sites measured over a period of 4 weeks...
April 22, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28434137/cholesterol-hydroperoxide-generation-translocation-and-reductive-turnover-in-biological-systems
#2
Albert W Girotti, Witold Korytowski
Cholesterol is like other unsaturated lipids in being susceptible to peroxidative degradation upon exposure to strong oxidants like hydroxyl radical or peroxynitrite generated under conditions of oxidative stress. In the eukaryotic cell plasma membrane, where most of the cellular cholesterol resides, peroxidation leads to membrane structural and functional damage from which pathological states may arise. In low density lipoprotein, cholesterol and phospholipid peroxidation have long been associated with atherogenesis...
April 22, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28429253/modified-metformin-as-a-more-potent-anticancer-drug-mitochondrial-inhibition-redox-signaling-antiproliferative-effects-and-future-epr-studies
#3
Balaraman Kalyanaraman, Gang Cheng, Micael Hardy, Olivier Ouari, Adam Sikora, Jacek Zielonka, Michael B Dwinell
Metformin, one of the most widely prescribed antidiabetic drugs in the world, is being repurposed as a potential drug in cancer treatment. Epidemiological studies suggest that metformin exerts anticancer effects in diabetic patients with pancreatic cancer. However, at typical antidiabetic doses the bioavailability of metformin is presumably too low to exert antitumor effects. Thus, more potent analogs of metformin are needed in order to increase its anticancer efficacy. To this end, a new class of mitochondria-targeted metformin analogs (or mito-metformins) containing a positively-charged lipophilic triphenylphosphonium group was synthesized and tested for their antitumor efficacy in pancreatic cancer cells...
April 21, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28417231/high-cholesterol-low-cholesterol-effects-in-biological-membranes-review
#4
Witold K Subczynski, Marta Pasenkiewicz-Gierula, Justyna Widomska, Laxman Mainali, Marija Raguz
Lipid composition determines membrane properties, and cholesterol plays a major role in this determination as it regulates membrane fluidity and permeability, as well as induces the formation of coexisting phases and domains in the membrane. Biological membranes display a very diverse lipid composition, the lateral organization of which plays a crucial role in regulating a variety of membrane functions. We hypothesize that, during biological evolution, membranes with a particular cholesterol content were selected to perform certain functions in the cells of eukaryotic organisms...
April 17, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28417230/retraction-note-to-vegf-silencing-inhibits-human-osteosarcoma-angiogenesis-and-promotes-cell-apoptosis-via-pi3k-akt-signaling-pathway
#5
Jian Zhao, Zi-Ru Zhang, Na Zhao, Bao-An Ma, Qing-Yu Fan
No abstract text is available yet for this article.
April 17, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28413858/epr-studies-on-the-properties-of-model-photoreceptor-membranes-made-of-natural-and-synthetic-lipids
#6
Mariusz Duda, Katarzyna Kawula, Anna Pawlak, Tadeusz Sarna, Anna Wisniewska-Becker
The membranes of retina photoreceptors have unique lipid composition. They contain a high concentration of polyunsaturated docosahexaenoic acid, with six double bonds, and are enriched in phosphatidylethanolamines. Based on their phospholipid composition and cholesterol content, membranes of photoreceptors can be divided into three types: plasma membrane, young disks membranes, and old disks membranes. High amount of docosahexaenoic acid, abundant illumination, and high respiratory demands make these membranes sensitive to oxidative stress and lipid peroxidation...
April 17, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28401421/redox-active-transition-metal-ions-make-melanin-susceptible-to-chemical-degradation-induced-by-organic-peroxide
#7
Andrzej Zadlo, Anna Pilat, Michal Sarna, Anna Pawlak, Tadeusz Sarna
With aging, retinal pigment epithelium melanosomes, by fusion with the age pigment lipofuscin, form complex granules called melanolipofuscin. Lipofuscin granules may contain oxidized proteins and lipid hydroperoxides, which in melanolipofuscin could chemically modify melanin polymer, while transition metal ions present in melanin can accelerate such oxidative modifications. The aim of this research was to examine the effect of selected transition metal ions on melanin susceptibility to chemical modification induced by the water-soluble tert-butyl hydroperoxide used as an oxidizing agent...
April 11, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28353142/analysis-of-species-selectivity-of-human-mouse-and-rat-cytochrome-p450-1a-and-2b-subfamily-enzymes-using-molecular-modeling-docking-and-dynamics-simulations
#8
Bagavathy Shanmugam Karthikeyan, Suvaiyarasan Suvaithenamudhan, Mohammad Abdulkader Akbarsha, Subbiah Parthasarathy
Cytochrome P450 (CYP) 1A and 2B subfamily enzymes are important drug metabolizing enzymes, and are highly conserved across species in terms of sequence homology. However, there are major to minor structural and macromolecular differences which provide for species-selectivity and substrate-selectivity. Therefore, species-selectivity of CYP1A and CYP2B subfamily proteins across human, mouse and rat was analyzed using molecular modeling, docking and dynamics simulations when the chiral molecules quinine and quinidine were used as ligands...
March 29, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28332021/female-hormone-17%C3%AE-estradiol-downregulated-mmp-2-expression-and-upregulated-a1pi-expression-in-human-corneal-stromal-cells
#9
Hongbo Yin, Qi Wan, Yan Tian, Bo Zhao, Yingping Deng
Collagens are essential for cornea functions. In non-ocular tissues, it has been demonstrated that sex hormones modulate the collagen remodeling. In this study, we investigated whether the primary female hormone 17β-estradiol plays a role in the expressions of matrix metalloproteinases and proteinase inhibitors in cultured human corneal stromal cells. We found that 17β-estradiol treatment significantly reduced the matrix metalloproteinase-2 mRNA in human corneal stromal cells as well as the matrix metalloproteinase-2 proteins, while the matrix metalloproteinase-9 mRNA level was not significantly altered...
March 23, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28321613/idh-inhibiting-small-molecule-dtdq-inhibits-migration-and-invasion-of-a549-human-non-small-cell-lung-cancer-cells-via-sequential-inactivation-of-erk-and-p38-signaling-pathways
#10
Soonchan Park, Jongsung Lee, Sang Yeol Lee
Migration and invasion are two core processes during cancer metastasis, and several signaling pathways have been shown to be involved. A key regulator of metastasis is the mitogen-activated protein kinase signaling pathway. Here, we report that the small molecule, 6,7-dimethyl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinolin-2(1H)-one, inhibited isocitrate dehydrogenase activity and had anti-metastatic effects in A549 human non-small-cell lung cancer cells. 6,7-dimethyl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinolin-2(1H)-one induced sequential inactivation of the extracellular signal-regulated kinases and p38 signaling pathways, both representative mitogen-activated protein kinase family members...
March 21, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28315132/nitroxide-radicals-synthesis-and-functional-bio-nanomaterials-an-introduction
#11
EDITORIAL
Alex I Smirnov, Lawrence J Berliner
No abstract text is available yet for this article.
March 17, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28281231/intrinsically-disordered-regions-in-serum-albumin-what-are-they-for
#12
REVIEW
Ekaterina A Litus, Sergei E Permyakov, Vladimir N Uversky, Eugene A Permyakov
Serum albumin is a major plasma protein in mammalian blood. The importance of this protein lies in its roles in both bioregulation and transport phenomena. Serum albumin binds various metal ions and participates in the transport and storage of fatty acids, bilirubin, steroids amino acids, and many other ligands, usually with regions of hydrophobic surface. Although the primary role of serum albumin is to transport various ligand, its versatile binding capacities and high concentration mean that it can assume a number of additional functions...
March 10, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28281230/identifying-the-interaction-of-vancomycin-with-novel-ph-responsive-lipids-as-antibacterial-biomaterials-via-accelerated-molecular-dynamics-and-binding-free-energy-calculations
#13
Shaimaa Ahmed, Suresh B Vepuri, Mahantesh Jadhav, Rahul S Kalhapure, Thirumala Govender
Nano-drug delivery systems have proven to be an efficient formulation tool to overcome the challenges with current antibiotics therapy and resistance. A series of pH-responsive lipid molecules were designed and synthesized for future liposomal formulation as a nano-drug delivery system for vancomycin at the infection site. The structures of these lipids differ from each other in respect of hydrocarbon tails: Lipid1, 2, 3 and 4 have stearic, oleic, linoleic, and linolenic acid hydrocarbon chains, respectively...
March 9, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28271339/spin-probe-multi-frequency-epr-study-of-unprocessed-cotton-fibers
#14
Antonin Marek, Maxim A Voinov, Alex I Smirnov
Known since the ancient times, cotton continues to be one of the essential materials for the human civilization. Cotton fibers are almost pure cellulose and contain both crystalline and amorphous nanodomains with different physicochemical properties. While understanding of interactions between the individual cellulose chains within the crystalline phase is important from a perspective of mechanical properties, studies of the amorphous phase lead to characterization of the essential transport parameters, such as solvent diffusion, dyeing, drug release, and toxin absorption, as well as more complex processes of enzymatic degradation...
March 7, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28210984/effect-of-solution-ionic-strength-on-the-pka-of-the-nitroxide-ph-epr-probe-2-2-3-4-5-5-hexamethylimidazolidin-1-oxyl
#15
Kaleigh Margita, Maxim A Voinov, Alex I Smirnov
Spin probe and spin labeling Electron Paramagnetic Resonance methods are indispensable research tools for solving a wide range of bioanalytical problems-from measuring microviscosity and polarity of phase-separated liquids to oxygen concentrations in tissues. One of the emerging uses of spin probes are the studies of proton transfer-related and surface electrostatic phenomena. The latter Electron Paramagnetic Resonance methods rely on molecular probes containing an additional functionality capable of reversible ionization (protonation, in particular) in the immediate proximity to an Electron Paramagnetic Resonance-active reporter group, such as (N-O(•)) for nitroxides...
February 17, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28197900/letter-from-the-editor-in-chief-2017
#16
EDITORIAL
Lawrence J Berliner
No abstract text is available yet for this article.
February 15, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28144904/vp40-of-the-ebola-virus-as-a-target-for-ebov-therapy-comprehensive-conformational-and-inhibitor-binding-landscape-from-accelerated-molecular-dynamics
#17
Marissa Balmith, Mahmoud E S Soliman
The first account of the dynamic features of the loop region of VP40 of the Ebola virus was studied using accelerated molecular dynamics simulations and reported herein. Among the proteins of the Ebola virus, the matrix protein (VP40) plays a significant role in the virus lifecycle thereby making it a promising therapeutic target. Of interest is the newly elucidated N-terminal domain loop region of VP40 comprising residues K127, T129, and N130 which when mutated to alanine have demonstrated an unrecognized role for N-terminal domain-plasma membrane interaction for efficient VP40-plasma membrane localization, oligomerization, matrix assembly, and egress...
March 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28111710/ip-10-cxcr3-axis-promotes-the-proliferation-of-vascular-smooth-muscle-cells-through-erk1-2-creb-signaling-pathway
#18
Hui-Jin Wang, Yu Zhou, Rui-Ming Liu, Yuan-Sen Qin, Ying-Huan Cen, Ling-Yu Hu, Shen-Ming Wang, Zuo-Jun Hu
Excessive proliferation of vascular smooth muscle cells is one of the main pathological processes leading to atherosclerosis and intimal hyperplasia after vascular interventional therapy. Our previous study has shown that interferon-γ inducible protein-10 contributes to the proliferation of vascular smooth muscle cell. However, the underlying mechanisms remain unclear. Extracellular signal-regulated kinase 1/2, serine/threonine kinase Akt, and cAMP response element binding protein are signaling pathways, which are considered to play important roles in the processes of vascular smooth muscle cell proliferation...
March 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28101696/role-of-the-helix-in-talin-f3-domain-f3-helix-in-talin-mediated-integrin-activation
#19
Ang Li, Qiang Guo, Ailin Wei, Yaliang Zhou, Weiming Hu
Increases in ligand binding to cellular integrins (activation) play an important role in platelet and leukocyte function. Talin is necessary in vivo and sufficient in vitro for integrin αIIbβ3 activation. The precise mechanisms by which talin activates integrin are still being elucidated. In particular, talin undergoes conformational changes (around the F3 helix) and inserts the F3 helix into lipid bilayer; however, the connection between this lipid-inserting mechanism of talin and talin's capacity to activate integrin has never been explored before...
March 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28054303/amino-acid-properties-of-trafficking-determinants-in-the-outer-pore-forming-region-of-kv1-potassium-channels-in-cell-lines
#20
Barbara Gomez, Jing Zhu, Esperanza Recio-Pinto, William B Thornhill
Different classes of Kv1 potassium channels have different trafficking patterns despite having very similar amino acid sequences. Two amino acids responsible for these differences have been identified in the outer pore turret region of Kv1.1 and Kv1.4. Here we tested a series of substitutions at these two determinants on Kv1.4. All P506 substitutions tested resulted in a significant decrease in surface protein, total protein, and protein half-life, indicating that proline is required at 506 to stabilize protein conformation and increase trafficking to the cell surface...
March 2017: Cell Biochemistry and Biophysics
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