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Biological Chemistry

Ly Nguyen, Peng Lu, Daniela Boehm, Paula Bourke, Brendan F Gilmore, Noreen J Hickok, Theresa A Freeman
Bacterial infection and antibiotic resistance are major threats to human health and very few solutions are available to combat this eventuality. A growing number of studies indicate that cold (non-thermal) plasma treatment can be used to prevent or eliminate infection from bacteria, bacterial biofilms, fungi and viruses. Mechanistically, a cold plasma discharge is composed of high-energy electrons that generate short-lived reactive oxygen and nitrogen species which further react to form more stable compounds (NO2, H2O2, NH2Cl and others) depending on the gas mixture and plasma parameters...
September 19, 2018: Biological Chemistry
Nežka Kavčič, Katarina Pegan, Peter Vandenabeele, Boris Turk
Oxidative stress has for a long time been associated with cell death, especially classical necrosis, however, its role in other cell death pathways is less clear. Here, we evaluated in a comparative way, the effect of four different reactive oxygen species (ROS) scavengers, N-acetyl-L-cysteine (NAC), α-tocopherol and two superoxide dismutase mimetics, n(III)tetrakis(4-benzoic acid)porphyrin chloride, and 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol), in four different cell death models, including menadione-triggered necrosis, staurosporine-induced apoptosis and tumor necrosis factor (TNF)-induced apoptosis and necroptosis...
September 19, 2018: Biological Chemistry
Jianfa Jiang, Kenan Yu, Zhaoying Jiang, Min Xue
Endometriosis (EMs) is a chronic inflammatory condition. Interleukin (IL)-37 is a member of the IL-1 family and an anti-inflammatory cytokine. This study aimed to evaluate the possible role of IL-37 in the EMs pathogenesis. We investigated the in vivo effect of IL-37 on EMs by injection with recombinant human IL-37 (rhIL-37) into EMs mice. Furthermore, we evaluated the in vitro effects of IL-37 on proliferation, adhesion, migration and invasiveness of endometrial stromal cells (ESCs), and explored whether Wnt/β-catenin and mitogen-activated protein kinase (MAPK) pathways were involved in this process...
September 19, 2018: Biological Chemistry
Barbara Di Ventura, Henning D Mootz
Synthetic biologists aim at engineering controllable biological parts such as DNA, RNA and proteins in order to steer biological activities using external inputs. Proteins can be controlled in several ways, for instance by regulating the expression of their encoding genes with small molecules or light. However, post-translationally modifying pre-existing proteins to regulate their function or localization leads to faster responses. Conditional splicing of internal protein domains, termed inteins, is an attractive methodology for this purpose...
September 18, 2018: Biological Chemistry
Peng Sun, Dan Zhang, Haiping Huang, Yafeng Yu, Zhendong Yang, Yuyu Niu, Jisheng Liu
This study aimed to investigate the role of miRNA-1225-5p (miR-1225) in laryngeal carcinoma (LC). We found that the expression of miR-1225 was suppressed in human LC samples, while CDC14B (cell division cycle 14B) expression was reinforced in comparison with surrounding normal tissues. We also demonstrated that enhanced expression of miR-1225 impaired the proliferation and survival of LC cells, and resulted in G1/S cell cycle arrest. In contrast, reduced expression of miR-1225 promoted cell survival. Moreover, miR-1225 resulted in G1/S cell cycle arrest and enhanced cell death...
September 15, 2018: Biological Chemistry
Irene A van Dijk, Enno C I Veerman, Eric A J Reits, Jan G M Bolscher, Jan Stap
Histatins are histidine-rich peptides present in the saliva of humans and higher primates and have been implicated in the protection of the oral cavity. Histatin 1 is one of the most abundant histatins and recent reports show that it has a stimulating effect on cellular adherence, thereby suggesting a role in maintaining the quality of the epithelial barrier and stimulating mesenchymal-to-epithelial transition. Here we summarize these findings and discuss them in the context of previous reports. The recent findings also provide new insights in the physiological functions of histatin 1, which are discussed here...
September 13, 2018: Biological Chemistry
Nagendra Kumar Kaushik, Bhagirath Ghimire, Ying Li, Manish Adhikari, Mayura Veerana, Neha Kaushik, Nayansi Jha, Bhawana Adhikari, Su-Jae Lee, Kai Masur, Thomas von Woedtke, Klaus-Dieter Weltmann, Eun Ha Choi
Non-thermal atmospheric pressure plasma has been proposed as a new tool for various biological and medical applications. Plasma in close proximity to cell culture media or water creates reactive oxygen and nitrogen species containing solutions known as plasma-activated media (PAM) or plasma-activated water (PAW) - the latter even displays acidification. These plasma-treated solutions remain stable for several days with respect to the storage temperature. Recently, PAM and PAW have been widely studied for many biomedical applications...
September 13, 2018: Biological Chemistry
Hermann Koepsell
In vitro evaluation of drugs for interaction with transporters is essential during drug development. As polyspecific organic cation transporters (OCTs) are critical for pharmacokinetics of many cationic drugs, in vitro testing of human OCT1 and human OCT2 is recommended. In the currently applied tests it is determined whether uptake of one model cation in stably transfected epithelial cells is inhibited using a substrate concentration in the micromolar range. In this review experimental evidence for the existence of low- and high-affinity cation binding sites in OCTs that may interact with drugs is compiled...
September 11, 2018: Biological Chemistry
Franziska Frank, Veronika Bezold, Kaya Bork, Philip Rosenstock, Jonas Scheffler, Rüdiger Horstkorte
No abstract text is available yet for this article.
September 7, 2018: Biological Chemistry
Shujun Wu, Hui Li, Chunya Lu, Furui Zhang, Huaqi Wang, Xinhua Lu, Guojun Zhang
No abstract text is available yet for this article.
September 4, 2018: Biological Chemistry
Lina Wauters, Susanne Terheyden, Bernd K Gilsbach, Margaux Leemans, Panagiotis S Athanasopoulos, Giambattista Guaitoli, Alfred Wittinghofer, Christian Johannes Gloeckner, Wim Versées, Arjan Kortholt
No abstract text is available yet for this article.
September 4, 2018: Biological Chemistry
Rita Mateus-Seidl, Sebastian Stahl, Stefan Dengl, Fabian Birzele, Hedda Herrmuth, Klaus Mayer, Gerhard Niederfellner, Xiu-Fen Liu, Ira Pastan, Ulrich Brinkmann
The functionality of eukaryotic translation elongation factor 2 (eEF2) is modulated by phosphorylation, eEF2 is simultaneously the molecular target of ADP-ribosylating toxins. We analyzed the interplay between phosphorylation and diphthamide-dependent ADPribosylation. Phosphorylation does not require diphthamide, eEF2 without it still becomes phosphorylated. ADP-ribosylation not only modifies the H715 diphthamide but also inhibits phosphorylation of S595 located in proximity to H715, and stimulates phosphorylation of T56...
September 1, 2018: Biological Chemistry
Yuna Horiuchi, Ryunosuke Ohkawa, Shao-Jui Lai, Azusa Yamazaki, Hayato Ikoma, Kouji Yano, Takahiro Kameda, Minoru Tozuka
High-density lipoprotein (HDL), also known as anti-atherogenic lipoprotein, consists of heterogeneous particles in terms of size, density, and composition, suggesting differences among HDL subclasses in characteristics and functions. We investigated the role of apolipoprotein E (apoE)-containing HDL, a minor HDL subclass, in the cholesterol efflux capacity (CEC) of HDL, which is its predominant atheroprotective function. The CEC of apoE-containing HDL was similar to that of apoE-deficient HDL, but the former exhibited a greater rate increase (1...
September 1, 2018: Biological Chemistry
Rachid Essalmani, Elodie Weider, Jadwiga Marcinkiewicz, Ann Chamberland, Delia Susan-Resiga, Anna Roubtsova, Nabil G Seidah, Annik Prat
No abstract text is available yet for this article.
August 31, 2018: Biological Chemistry
Zhiguo Li, Xinwei Han
No abstract text is available yet for this article.
August 27, 2018: Biological Chemistry
Collins Otieno Nyongesa, Soyeun Park
No abstract text is available yet for this article.
August 23, 2018: Biological Chemistry
Susanne Eschenburg, Thomas F Reubold
No abstract text is available yet for this article.
August 23, 2018: Biological Chemistry
Daniela Boehm, Paula Bourke
No abstract text is available yet for this article.
August 23, 2018: Biological Chemistry
Santi M Mandal, Sounik Manna, Sneha Mondal, Ananta K Ghosh, Ranadhir Chakraborty
While antibiotics remain as a major therapy against life threatening pathogenic infections, they often lead to side effects like rashes, gastrointestinal and central nervous system reactions to serious allergies or organ damage. These adverse effects alongside the emergence of multi-antibiotic resistant bacteria and the decline in the development of new antibiotics, have posed a serious impediment for effective antibiotic therapy. A paradigm shift in attitudes has led us to think about the possibility of controlling infections with the indigenous antimicrobial peptides synthesized by human beings...
August 13, 2018: Biological Chemistry
Maria Igotti, Olga Gnedina, Alisa Morshneva, Svetlana Svetlikova, Valery Pospelov
This study aimed to explore a role of p21Waf1 in γH2AX foci formation and DNA repair as assessed by a Host-Cell Reactivation Assay in wild-type (p21Waf+/+) and p21Waf1-deficient E1A+Ras-transformed cells. p21Waf1+/+ cells have low γH2AX background compared to p21Waf1-/- cells. The treatment with histone deacetylase inhibitor (HDI) sodium butyrate (NaBut) causes to accumulation of γH2AX in p21Waf+/+ cells with little effect in p21Waf-/- cells. Moreover, NaBut inhibits DNA repair in wt cells but not in p21Waf1-/- cells...
August 11, 2018: Biological Chemistry
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