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Stress: the International Journal on the Biology of Stress

Julie Berg Schmidt, Christel Johanneson Bertolt, Anders Sjödin, Frederik Ackermann, Anne Vibeke Schmedes, Henriette Lynge Thomsen, Anne Marie Juncher, Mads F Hjorth
Lay summary: Human and animal studies have shown that chronic stress interfers with both homeostatic and hedonic appetite control. Here, we investigated the effect of chronic stress on food preferences and eating behavior in real life settings. In random order, fifty healthy students participated in two test periods of 4-5 days; a stressful period (one week prior to an examination) and a nonstressful period (four weeks after an examination). Food preferences were assessed by counting money spent on highly rewarding foods bought with gift certificates, and changes in eating behavior was further assessed by the Three Factor Eating Questionnaire...
November 2, 2018: Stress: the International Journal on the Biology of Stress
Márcio Silveira Corrêa, Daiane Borba de Lima, Bruno Lima Giacobbo, Kelem Vedovelli, Irani Iracema de Lima Argimon, Elke Bromberg
Familial caregivers of Alzheimer's disease (AD) patients experience an emotional and physical burden which characterizes a chronic stress condition. The resulting hypothalamic-pituitary-adrenal axis dysfunction favors an imbalance of neurotoxic/neuroprotective factors and causes cognitive impairments, increasing the caregivers' risk for cognitive decline and compromising their ability to provide adequate care of the patient. Therefore, the present study aimed to investigate the reversibility of the cognitive impairments of familial caregivers of AD patients during their caregiving-related chronic stress condition...
November 1, 2018: Stress: the International Journal on the Biology of Stress
Christian Schinke, Swen Hesse, Michael Rullmann, Georg-Alexander Becker, Julia Luthardt, Franziska Zientek, Marianne Patt, Muriel Stoppe, Elisa Schmidt, Klara Meyer, Philipp M Meyer, Johannes Orthgieß, Matthias Blüher, Jürgen Kratzsch, Yu-Shin Ding, Florian Then Bergh, Osama Sabri
The central noradrenaline (NA) stress-response network co-mediates hypothalamic-pituitary-adrenal (HPA) axis activation and arginine-vasopressin (AVP) release. Dysregulation of these systems contributes to stress-related diseases such as human obesity, but their interrelation remains unclear. The study was aimed to test for the first time in vivo whether central noradrenergic activity quantitatively indexed by the availability of the presynaptic NA transporter (NAT) is associated with HPA axis responsiveness as measured with the combined dexamethasone suppression/corticotropin releasing hormone stimulation (dex/CRH) test and copeptin as a surrogate marker of the serum AVP tone in highly obese, otherwise, healthy individuals compared to age- and sex-matched non-obese, healthy controls...
October 29, 2018: Stress: the International Journal on the Biology of Stress
V M Ignatiuk, M S Izvolskaya, V S Sharova, S N Voronova, L A Zakharova
Stress signals during fetal or early postnatal periods may disorganize reproductive axis development at different levels. This study was aimed to test the hypothesis that prenatal immunological stress induced by bacterial endotoxin, lipopolysaccharide (LPS), has impact on structure and function of the reproductive system in female offspring. Adult female Wistar rats were divided into two groups, a control group (n = 5) and a LPS group (n = 12). Rats were injected with LPS 50 μg/kg body or 0.9% saline intraperitoneally on the 12th day of pregnancy...
October 29, 2018: Stress: the International Journal on the Biology of Stress
André Esser, Thomas Kraus, Andreas Tautz, Helmut Minten, Jessica Lang
The allostatic load index (ALI) assesses the physiological adaption to chronic stress by cumulative changes in the circulation, respiration, inflammation, metabolic and anthropometric systems. The ALI thus can function as a risk marker for secondary prevention in occupational medicine. The aim of this study was to investigate the feasibility of creating a predictive marker by using data from an executive checkup program of an international company and to examine its relationship to work-related surrogate health parameters...
October 23, 2018: Stress: the International Journal on the Biology of Stress
Robin Hermann, Bianca Biallas, Hans-Georg Predel, Katja Petrowski
As a time-efficient training system, high intensity interval training (HIIT) is well known for several beneficial effects. However, the literature on the stress-generating effects of HIIT shows a research deficit. A standardized comparable stressor and different kinds of stress-parameters are needed for quantifying the results. The present study examined the hormonal, autonomic, and psychological stress outcomes of HIIT compared to a standardized psychosocial stressor and tested the cross-stressor-adaptation (CSA) hypothesis which implies a stress-buffering effect at a good fitness level...
October 21, 2018: Stress: the International Journal on the Biology of Stress
Xingxing Mo, Xiao Wang, Qinmin Ge, Fan Bian
Oxidative stress is one of the key mechanisms of sepsis related organ dysfunction including stress hyperglycemia. Silent mating type information regulation 2 homolog 1 (SIRT1) could regulate glucose metabolism through its deacetylase activity. In this study, we aimed to investigate the role of SIRT1/forkhead box protein 1 (FoxO1) pathway on lipopolysaccharide (LPS) induced INS-1 cells dysfunction from aspects of oxidative stress and apoptosis. After being treated with 1 mg/L LPS together with or without SIRT1 activator resveratrol (RSV) or SIRT1 inhibitor EX527, cell viability, ROS generation, malondialdehyde (MDA), superoxide, insulin secretion, and activity of superoxide dismutase (SOD) in INS-1 cells were measured by specific assays...
October 20, 2018: Stress: the International Journal on the Biology of Stress
Monireh-Sadat Mousavi, Gholamhossein Riazi, Alireza Imani, Sogol Meknatkhah, Nahid Fakhraei, Shahriar Pooyan, Nahid Tofigh
Multiple adult health problems are associated with adolescent stress. As the brain discriminates physical and psychological stressors by activation of different neural networks, we hypothesized that behavioral and physiological performance would be modulated differently based on the nature of the stressors. Thus, we studied the comparative effects of adolescent repeated physical and psychological stresses on adult cognitive performance, pro-oxidant-antioxidant balance (PAB) and heart rate in female rats. The aim was to differentiate disparate potency of chronic psychological and physical stresses leading to long-term behavioral and physiological alterations...
October 20, 2018: Stress: the International Journal on the Biology of Stress
Anna Skórzewska, Aleksandra Wisłowska-Stanek, Małgorzata Lehner, Danuta Turzyńska, Alicja Sobolewska, Paweł Krząścik, Janusz Szyndler, Piotr Maciejak, Adam Płaźnik
This study aimed to test the hypothesis that high-anxiety (HR) rats are more sensitive to the effects of chronic corticosterone administration and antalarmin (corticotropin-releasing factor (CRF) receptor 1, CRF1 antagonist) injections than low-anxiety (LR) rats, and this effect is accompanied by changes in CRF system activity in brain regions involved in the control of emotions and the hypothalamic-pituitary-adrenal (HPA) axis. Male rats were divided into LR (n = 25) and HR (n = 30) groups according to the duration of conditioned freezing in a contextual fear test...
October 20, 2018: Stress: the International Journal on the Biology of Stress
Ross W May, Gregory S Seibert, Marcos A Sanchez-Gonzalez, Frank D Fincham
With the detrimental relationship between school burnout and physiological and cognitive functioning now well documented, interventions to ameliorate school burnout symptomology are needed. This study examined the effectiveness of a self-regulatory biofeedback intervention program (Heart Rate Variability Coherence Biofeedback Training [HRVCB]) in contrast to a protocol demonstrated to produce cognitive and physiological improvements (a high intensity interval training protocol [HIIT]) as well as a wait-list control condition at decreasing school burnout in an American collegiate sample (N = 90)...
October 20, 2018: Stress: the International Journal on the Biology of Stress
Jo Wrigglesworth, Marie-Laure Ancelin, Karen Ritchie, Joanne Ryan
A recent study reported for the first time, that DNA methylation of the KITLG gene mediates the association between childhood trauma and cortisol stress reactivity. Our study aimed to provide the first independent replication of these findings. ESPRIT is a prospective study of community-dwelling participants (age ≥ 65), randomly selected from the electoral rolls of the Montpellier district, in France. Clinical depression was assessed using the Mini-International Neuropsychiatric Interview (MINI, French version 5...
October 9, 2018: Stress: the International Journal on the Biology of Stress
Mathias V Schmidt, Alon Chen
No abstract text is available yet for this article.
September 2018: Stress: the International Journal on the Biology of Stress
Brittany L Smith, Rachel L Morano, Yvonne M Ulrich-Lai, Brent Myers, Matia B Solomon, James P Herman
The late adolescent period is characterized by marked neurodevelopmental and endocrine fluctuations in the transition to early adulthood. Adolescents are highly responsive to the external environment, which enhances their ability to adapt and recover from challenges when given nurturing influences, but also makes them vulnerable to aberrant development when exposed to prolonged adverse situations. Female rats are particularly sensitive to the effects of chronic stress in adolescence, which manifests as passive coping strategies and blunted hypothalamo-pituitary adrenocortical (HPA) stress responses in adulthood...
September 2018: Stress: the International Journal on the Biology of Stress
Jenny Hadrévi, Ingibjörg H Jonsdottir, Per-Anders Jansson, Jan W Eriksson, Anna Sjörs
Exhaustion disorder (ED) is a stress-related disorder that often implies a great burden on the individual patient as well as on society. Previous studies have shown that ED is associated with metabolic deviations, such as lowered fasting glucose. Several mechanisms have been discussed as a plausible explanation of the lack of energy described by these patients. Metabolic processes and reduced ability to mobilize energy have been suggested as important factors. This study investigated metabolomics in 20 patients diagnosed with ED and compared them with 21 healthy controls...
August 7, 2018: Stress: the International Journal on the Biology of Stress
Brita Roy, Carley Riley, Rajita Sinha
Chronic stress is a risk factor for incident cardiovascular (CV) disease. Emotion regulation is the ability to modulate one's state or behavior in response to a given situation or stressor, and may mitigate the effect of chronic stress on CV disease risk. Data from a cohort of 754 community-dwelling young to middle-aged adults who were assessed between 2007 and 2012 on stress, emotion regulation, and CV risk measures were used to test the hypothesis that emotion regulation mitigates the effect of chronic stress on CV risk...
August 7, 2018: Stress: the International Journal on the Biology of Stress
Ugo Cappucci, Giulia Torromino, Assunta Maria Casale, Jeremy Camon, Fabrizio Capitano, Maria Berloco, Andrea Mele, Sergio Pimpinelli, Arianna Rinaldi, Lucia Piacentini
Transposable elements (TEs) are conserved mobile genetic elements that are highly abundant in most eukaryotic genomes. Although the exact function of TEs is still largely unknown, it is increasingly clear that they are significantly modulated in response to stress in a wide range of organisms, either directly or indirectly through regulation of epigenetic silencing. We investigated the effect of repeated restraint stress (2 h a day, for 5 d) on transcription levels of LINE-1 (L1) retrotransposon in the brain of inbred BALB/c, DBA/2, C57BL/6N, and outbred CD1 mice...
July 11, 2018: Stress: the International Journal on the Biology of Stress
Alina Kistenmacher, Jakob Goetsch, Dorothee Ullmann, Ewelina K Wardzinski, Uwe H Melchert, Kamila Jauch-Chara, Kerstin M Oltmanns
Psychosocial stress may lead to increased food consumption and overweight. In turn, obesity is related to reduced brain energy content. We hypothesized that psychosocial stress influencing food intake may alter the neuroenergetic status in the human brain. We tested 14 healthy normal weight men in a randomized crossover design. A modified version of the Trier Social Stress Test (TSST) was carried out to induce psychosocial stress vs. control in a neuroimaging setting. Cerebral energy content, i.e. high energy phosphates adenosine triphosphate (ATP) and phosphocreatine (PCr), was measured by 31 phosphorus magnetic resonance spectroscopy...
July 3, 2018: Stress: the International Journal on the Biology of Stress
Damek Homiack, Emma O'Cinneide, Sema Hajmurad, Gary P Dohanich, Laura A Schrader
Post-traumatic stress disorder (PTSD) is characterized by the development of paradoxical memory disturbances including intrusive memories and amnesia for specific details of the traumatic experience. Despite evidence that women are at higher risk to develop PTSD, most animal research has focused on the processes by which male rodents develop adaptive fear memory. As such, the mechanisms contributing to sex differences in the development of PTSD-like memory disturbances are poorly understood. In this investigation, we exposed adult male and female Wistar rats to the synthetic alarm odor 2,4,5-trimethylthiazole (TMT) to assess development of generalized fear behavior and rapid modulation of glutamate uptake and signaling cascades associated with hippocampus-dependent long-term memory...
July 2018: Stress: the International Journal on the Biology of Stress
Hanna Malmberg Gavelin, Therese Eskilsson, Carl-Johan Boraxbekk, Maria Josefsson, Anna Stigsdotter Neely, Lisbeth Slunga Järvholm
Stress-related exhaustion has been associated with selective and enduring cognitive impairments. However, little is known about how to address cognitive deficits in stress rehabilitation and how this influences stress recovery over time. The aim of this open-label, parallel randomized controlled trial ( NCT03073772) was to investigate the long-term effects of 12 weeks cognitive or aerobic training on cognitive function, psychological health, and work ability for patients diagnosed with exhaustion disorder (ED)...
July 2018: Stress: the International Journal on the Biology of Stress
Antônio Ribeiro-Oliveira, Junia R O L Schweizer, Pedro H S Amaral, Mariana F Bizzi, Warley Cezar da Silveira, Daniel T A Espirito-Santo, Giancarlo Zille, Beatriz S Soares, Herbert A Schmid, Kevin C J Yuen
Pasireotide is a new-generation somatostatin analog that acts through binding to multiple somatostatin receptor subtypes. Studies have shown that pasireotide induces hyperglycemia, reduces glucocorticoid secretion, alters neurotransmission, and potentially affects stress responses typically manifested as hyperglycemia and increased corticosterone secretion. This study specifically aimed to evaluate whether pasireotide treatment modifies glucose and costicosterone secretion in response to acute restraint stress...
July 2018: Stress: the International Journal on the Biology of Stress
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