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Seminars in Cutaneous Medicine and Surgery

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https://www.readbyqxmd.com/read/29719009/skin-disease-education-foundation-s-42nd-annual-hawaii-dermatology-seminar%C3%A2-scientific-abstracts
#1
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719024/molecular-advances-in-cutaneous-t-cell-lymphoma
#2
Armando N Bastidas Torres, Safa Najidh, Cornelis P Tensen, Maarten H Vermeer
Cutaneous T-cell lymphoma (CTCL) is a group of malignancies derived from skin-homing T cells. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common CTCL variants. In recent years, the genetic landscape of SS/MF has been characterized using genome-wide nextgeneration sequencing approaches. These studies have revealed that genes subjected to oncogenic mutations take part in cell cycle regulation, chromatin modification, Janus kinase (JAK)-signal transducer and activator of transcription protein (STAT) signaling, T-cell receptor (TCR)/ nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling, and microtubule associated protein kinase (MAPK) signaling, which suggests that deregulation of these cellular processes underlies lymphomagenesis...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719023/maximizing-the-clinical-utility-of-descriptive-lymphoid-pathology-reporting
#3
Timothy H McCalmont
Dermatopathology reporting can be both exact and inexact. Exact reporting represents the use of terminology that corresponds to a disease sui generis, such as discoid lupus erythematosus or disseminated superficial porokeratosis. Inexact reporting can vary greatly amongst various practitioners-both in terms of the exact semantics used and also stylistically-and can be used habitually by pathologists as a means to provide cover for diagnostic uncertainty or inexperience. This article explores the use of descriptive (inexact) reporting as it applies to cutaneous lymphoma and its differential diagnosis...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719022/approach-to-dermal-based-lymphoid-infiltrates-and-proliferations
#4
Yann Charli-Joseph, Sonia Toussaint-Claire, Carmen Lome-Maldonado, Daniel Montante-Montes de Oca, Carlos Ortiz-Hidalgo
The histopathological diagnosis of dermal-based lymphoid infiltrates and proliferations is often challenging due to the vast list of biologically diverse entities that archetypally or occasionally center in the mid-dermis, especially because significant overlap exists in their clinical, histopathologic, and immunophenotypic features. The differential diagnosis includes reactive infiltrates in common and rare inflammatory dermatoses, benign conditions that may mimic lymphoid neoplasms (pseudolymphomas), and true clonal proliferations arising either primarily in the skin or rarely in extracutaneous tissues with secondary cutaneous dissemination...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719021/histopathologic-approach-to-epidermotropic-lymphocytic-infiltrates
#5
Shyam S Raghavan, Jinah Kim
Mycosis fungoides is the most common and therefore quintessential cutaneous lymphoma and is typically characterized by an epidermotropic infiltrate of atypical monoclonal CD4+ lymphocytes. Classical histopathologic findings include epidermotropism, lymphocytes with convoluted nuclear contours and surrounding perinuclear "halos," and papillary dermal fibrosis. Atypical lymphocytes may occasionally form Pautrier's microabscesses with tagging of lymphocytes along the basal keratinocytes. Unfortunately, a variety of benign inflammatory infiltrates, as well as other cutaneous lymphomas, may demonstrate some similar histopathologic findings...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719020/primary-cutaneous-b-cell-lymphomas-clinical-and-histopathologic-features-differential-diagnosis-and-treatment
#6
Steven T Chen, Jeffrey Barnes, Lyn Duncan
Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are rare. Given the variable natural history of the CBCL, proper classification is critical so that patients are treated appropriately. CBCLs can be divided into 2 main groups: indolent and aggressive...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719019/primary-cutaneous-cd4-small-medium-t-cell-lymphoproliferative-disorder-clinical-and-histopathologic-features-differential-diagnosis-and-treatment
#7
Alejandro A Gru, Mark R Wick, Mary Eid
Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder usually presents as a slow-growing and asymptomatic solitary lesion in the form of a nodule or tumor in the head and neck region. By definition, it is histologically characterized by small- to medium-sized CD4+ lymphocytes involving the dermis in a dense and either nodular or diffuse pattern. Epidermotropism should be absent or minimal. Tumor cells are accompanied by numerous reactive B cells, plasma cells, histiocytes, and eosinophils...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719018/nk-t-cell-lymphoma-nasal-type-%C3%AE-%C3%AE-t-cell-lymphoma-and-cd8-positive-epidermotropic-t-cell-lymphoma-clinical-and-histopathologic-features-differential-diagnosis-and-treatment
#8
Shamir Geller, Patricia L Myskowski, Melissa Pulitzer
The cytotoxic lymphomas of the skin constitute a heterogeneous group of rare lymphoproliferative diseases that are derived from mature T cells and natural killer (NK) cells that express cytotoxic molecules (T-cell intracellular antigen- 1, granzyme A/B, and perforin). Although frequently characterized by an aggressive course and poor prognosis, these diseases can have variable clinical behavior. This review delivers up-to-date information about the clinical presentation, histopathologic features, differential diagnosis, and therapy of extranodal NK/T-cell lymphoma, nasal type, primary cutaneous gamma delta T-cell lymphoma, and primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719017/cutaneous-cd30-positive-t-cell-lymphoproliferative-disorders-clinical-and-histopathologic-features-differential-diagnosis-and-treatment
#9
Werner Kempf, Katrin Kerl, Christina Mitteldorf
Cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPD) are the second most common form of cutaneous T-cell lymphoma. CD30+ LPD include lymphomatoid papulosis, primary cutaneous anaplastic large-cell lymphoma, and borderline lesions. Despite expression of CD30 by the neoplastic cells as the hallmark of these disorders, they differ in their clinical presentation and histological features as well as the course, the prognosis, and consecutively in the treatment. Diagnosis of CD30+ LPD and distinction from the broad spectrum of differential diagnoses essentially depends on clinicopathologic correlation as well as the results of staging examinations...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719016/s%C3%A3-zary-syndrome-clinical-and-histopathologic-features-differential-diagnosis-and-treatment
#10
Kerith E Spicknall
Sézary syndrome (SS) is a rare subtype of cutaneous T-cell lymphoma marked by erythroderma, circulating neoplastic T cells, and poor prognosis. Its low incidence has made the study of its etiology, immunologic/molecular pathways, and effective treatments difficult. Because histopathology may be nonspecific in SS, microscopic findings must be correlated with the clinical presentation and the results of blood evaluation in order to make the diagnosis. Treatments that preserve, rather than compromise, the immune system are preferred...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719015/mycosis-fungoides-variants-clinicopathologic-features-differential-diagnosis-and-treatment
#11
Rein Willemze
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, which typically presents with erythematous patches and plaques, histopathologically characterized by superficial infiltrates of small to mediumsized atypical epidermotropic T cells. Apart from this classic type of MF, many clinical and/or histopathologic variants have been described. Correct diagnosis of these MF variants is important, but may be difficult, because they may mimic a wide variety of inflammatory skin diseases. In this review, clinical and histopathologic characteristics of distinct variants of MF are presented, and their differential diagnosis and therapeutic options are discussed...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29719014/mycosis-fungoides-clinical-and-histopathologic-features-differential-diagnosis-and-treatment
#12
Lorenzo Cerroni
Mycosis fungoides (MF) is the most common type of cutaneous lymphoma. The term MF should be used only for the classical presentation of the disease characterized by the evolution of patches, plaques, and tumors or for variants showing a similar clinical course. MF is divided into 3 clinical phases: patch, plaque, and tumor stage, and the clinical course is usually protracted over years or decades. Histopathologically, MF is characterized by an epidermotropic infiltrate of T lymphocytes that displays in most cases a helper phenotype...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29614139/practical-strategies-for-optimizing-management-of-psoriasis
#13
Jashin J Wu, April W Armstrong, Kenneth B Gordon, M Alan Menter
Approximately 30% of patients with moderate plaque psoriasis and 20% of those with severe psoriasis have inadequate disease control with their current therapeutic regimens. Among the factors that affect treatment efficacy are drug selection and lack of patient adherence to treatment, which is often due to patient frustration that psoriasis is a chronic, multisystemic, and incurable disease. By forming a strong therapeutic alliance with patients and by asking them about their expectations for treatment, clinicians have a better chance of providing patients with more effective and durable relief from their psoriasis symptoms...
February 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29614138/common-and-not-so-common-comorbidities-of-psoriasis
#14
M Alan Menter, April W Armstrong, Kenneth B Gordon, Jashin J Wu
Plaque psoriasis is increasingly recognized as a multisystemic disease whose most common comorbidities include psoriatic arthritis, cardiovascular disease, metabolic syndrome, overweight/obesity, inflammatory bowel disease, and depression. The presence of such comorbidities affects the therapeutic choices for clinicians. Patients often visit dermatologists more frequently than they do other clinicians, so it is incumbent upon dermatologists to recognize and address early signs of psoriatic comorbidities to prevent further deterioration and improve their patients' quality of life...
February 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29614137/treating-to-target-a-realistic-goal-in-psoriasis
#15
Kenneth B Gordon, April W Armstrong, M Alan Menter, Jashin J Wu
For many patients, the new biologic therapies for psoriasis can improve Psoriasis Area and Severity Index (PASI) scores in a relatively short time. But when results are less than optimal, patients often become frustrated. By providing effective medical treatment using a treat-to-target strategy, clinicians can relieve symptoms and halt disease progression. Although body surface area (BSA) and PASI scores are appropriate for analyzing results of clinical trials, clinicians need to use more patient-centered assessments of patients' progress such as the Dermatology Life Quality Index (DLQI) and Psoriasis Symptom Inventory (PSI), as well as other validated patientreported outcomes, which can enable them to set realistic and achievable goals for individual patients...
February 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29614136/the-evolving-landscape-of-psoriasis-treatment
#16
April W Armstrong, Kenneth B Gordon, M Alan Menter, Jashin J Wu
The process of discovering new drugs for plaque psoriasis has revealed much about the multisystemic nature of the disease. Current and emerging biologic agents may reliably achieve a Psoriasis Area and Severity Index (PASI 75) up to 90. Initially, clinicians select therapies based on the severity of the psoriasis. Although mild disease can be treated with topical agents, for patients with moderate to severe disease, concurrent therapy with oral systemic agents, biologics, and/ or phototherapy needs to be considered...
February 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29614135/introduction
#17
Alan M Menter
No abstract text is available yet for this article.
February 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29659641/introduction
#18
Lawrence F Eichenfield
No abstract text is available yet for this article.
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29292805/scientific-abstracts-skin-disease-education-foundation-s-18th-annual-las-vegas-dermatology-seminar%C3%A2
#19
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29224039/state-of-the-art-lasers-and-light-treatments-for-vascular-lesions-from-red-faces-to-vascular-malformations
#20
Manuel Valdebran, Brent Martin, Kristen M Kelly
Notable milestones in the treatment of vascular lesions have been achieved over the past century. Many cutaneous vascular lesions can be successfully treated with lightbased devices. In this review, we will discuss the treatment of port-wine birthmarks, lymphatic malformations, infantile hemangiomas, rosacea, venous lakes, pyogenic granulomas, cherry angiomas, and angiofibromas using lasers, total reflection amplification of spontaneous emission of radiation, intense pulsed light, and photodynamic therapy. In addition, for several of these diagnoses, we will review medical therapies that can be combined with light-based devices to provide enhanced results...
December 2017: Seminars in Cutaneous Medicine and Surgery
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