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Respirology: Official Journal of the Asian Pacific Society of Respirology

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https://www.readbyqxmd.com/read/30242794/emerging-therapies-in-adult-and-paediatric-bronchiectasis
#1
REVIEW
Kate H Regan, Adam T Hill
Bronchiectasis is a chronic respiratory disorder characterized by persistent productive cough and recurrent chest infections secondary to permanent structural airway damage. The current treatment strategies for this debilitating disorder are limited to prompt antibiotic treatment of infective exacerbations and regular airway clearance techniques. Despite its high morbidity and associated mortality across all age groups, it has been a neglected area of research in respiratory medicine and there remain no licensed disease-modifying therapies...
September 21, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30242790/high-pressure-non-invasive-ventilation-during-exercise-in-copd-patients-with-chronic-hypercapnic-respiratory-failure-a-randomized-controlled-cross-over-trial
#2
Rainer Gloeckl, Vasileios Andrianopoulos, Antje Stegemann, Julian Oversohl, Tessa Schneeberger, Ursula Schoenheit-Kenn, Wolfgang Hitzl, Michael Dreher, A Rembert Koczulla, Klaus Kenn
No abstract text is available yet for this article.
September 21, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30231301/red-blood-cell-transfusion-in-acute-pulmonary-embolism
#3
LETTER
Kailei Du, Ligang Bao, Yanfei Shen
No abstract text is available yet for this article.
September 19, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30230659/melbourne-epidemic-thunderstorm-asthma-event-2016-lessons-learnt-from-the-perfect-storm
#4
REVIEW
Francis Thien
No abstract text is available yet for this article.
September 19, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30230655/triaging-treatable-traits-in-asthma
#5
EDITORIAL
Christina Baggott, Richard Beasley
No abstract text is available yet for this article.
September 19, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30230650/annual-decline-in-arterial-blood-oxygen-predicts-development-of-chronic-respiratory-failure-in-copd-with-mild-hypoxaemia-a-6-year-follow-up-study
#6
Kiyoshi Uemasu, Susumu Sato, Shigeo Muro, Atsuyasu Sato, Naoya Tanabe, Koichi Hasegawa, Yoko Hamakawa, Tatsushi Mizutani, Yoshinori Fuseya, Kazuya Tanimura, Tamaki Takahashi, Toyohiro Hirai
BACKGROUND AND OBJECTIVE: Chronic respiratory failure (CRF) with hypoxaemia is an important pathophysiology in patients with chronic obstructive pulmonary disease (COPD), and existing mild hypoxaemia may be a sign of future CRF development. However, little is known about the trajectory of partial arterial pressure of oxygen (PaO2 ) decline in patients with COPD. We assessed decline in PaO2 and the impact of short-term reductions in PaO2 to predict future decline in PaO2 . METHODS: A total of 172 outpatients with COPD from a prospective cohort study were enrolled...
September 19, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30230137/treatable-traits-can-be-identified-in-a-severe-asthma-registry-and-predict-future-exacerbations
#7
Vanessa M McDonald, Sarah A Hiles, Krystelle Godbout, Erin S Harvey, Guy B Marks, Mark Hew, Matthew Peters, Philip G Bardin, Paul N Reynolds, John W Upham, Melissa Baraket, Zaheerodin Bhikoo, Jeffrey Bowden, Ben Brockway, Li Ping Chung, Belinda Cochrane, Gloria Foxley, Jeffrey Garrett, Lata Jayaram, Christine Jenkins, Constance Katelaris, Gregory Katsoulotos, Mariko S Koh, Vicky Kritikos, Marina Lambert, David Langton, Alexis Lara Rivero, Peter G Middleton, Aldoph Nanguzgambo, Naghmeh Radhakrishna, Helen Reddel, Janet Rimmer, Anne Marie Southcott, Michael Sutherland, Francis Thien, Peter A B Wark, Ian A Yang, Elaine Yap, Peter G Gibson
BACKGROUND AND OBJECTIVE: A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data and whether particular treatable traits were associated with future exacerbation risk. METHODS: The Australasian Severe Asthma Web-Based Database (SAWD) enrolled 434 participants with severe asthma and a comparison group of 102 participants with non-severe asthma...
September 19, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30226301/obstructive-sleep-apnoea-and-cholesterol-independence-in-context
#8
EDITORIAL
Shane A Landry, Simon A Joosten
No abstract text is available yet for this article.
September 18, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30223306/modification-of-the-prolonged-mechanical-ventilation-prognostic-model-score-to-predict-short-term-and-1-year-mortalities
#9
Yu Rang Park, Ji Sung Lee, Hwa Jung Kim, Sang-Bum Hong, Chae-Mann Lim, Younsuck Koh, Jin Won Huh
BACKGROUND AND OBJECTIVE: We aimed to validate the use of the Prolonged Mechanical Ventilation Prognostic Model (ProVent) score in medically ill patients with co-morbidities and to modify the score to improve the prediction power of 1-year mortality. METHODS: We conducted a retrospective study of all patients who required at least 14 days of mechanical ventilation (MV) and established two groups (14-20 and ≥21 days of MV) based on the MV duration. We performed external validation of the present ProVent Model in our patients on Day 14 (or Day 21 for the ≥21-day MV group) of MV, and established the extended ProVent model, while considering the albumin and bilirubin levels and co-morbidities (chronic obstructive pulmonary disease and cancer)...
September 17, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30218470/insights-into-respiratory-disease-through-bioinformatics
#10
REVIEW
Bhavna Hurgobin, Emma de Jong, Anthony Bosco
Respiratory diseases such as asthma, chronic obstructive pulmonary disease and lung cancer represent a critical area for medical research as millions of people are affected globally. The development of new strategies for treatment and/or prevention, and the identification of biomarkers for patient stratification and early detection of disease inception are essential to reducing the impact of lung diseases. The successful translation of research into clinical practice requires a detailed understanding of the underlying biology...
September 14, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30215873/work-environment-risks-for-health-care-workers-with-cystic-fibrosis
#11
Scott C Bell, David Armstrong, Glenys Harrington, Luke Jardine, Rebekah Divakaran, Bebe Loff, Peter G Middleton, Tim McDonald, Karen Rowland, Michael Wishart, Michelle E Wood, Rhonda L Stuart
In Australia and New Zealand, >50% of people with cystic fibrosis (CF) are adults and many of these people are pursuing vocational training and undertaking paid employment. More than 6% of adults with CF are working in health care. There is limited guidance in literature to support health care workers with CF (HCWcf) in training and in employment to support safe practice and to provide protection for themselves and their patients from the acquisition of health care associated infection. A multidisciplinary team of CF and Infectious Disease Clinicians, Infection Prevention and Control Practitioners, HCWcf, academic experts in medical ethics and representatives from universities, appraised the available evidence on the risk posed to and by HCWcf...
September 14, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30209855/high-intensity-inspiratory-muscle-training-in-bronchiectasis-a-randomized-controlled-trial
#12
Ozge Ozalp, Deniz Inal-Ince, Aslihan Cakmak, Ebru Calik-Kutukcu, Melda Saglam, Sema Savci, Naciye Vardar-Yagli, Hülya Arikan, Jale Karakaya, Lütfi Coplu
BACKGROUND AND OBJECTIVE: Inspiratory muscle training (IMT) enhances velocity of inspiratory muscle contraction and modifies inspiratory and expiratory time. This study aimed to examine the impact of high-intensity IMT (H-IMT) on exercise capacity in bronchiectasis. METHODS: Forty-five patients were included. Lung function, respiratory muscle strength and endurance, exercise capacity, dyspnoea, fatigue and quality of life (QOL) were evaluated. Patients were randomized into two groups: H-IMT and control groups...
September 12, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30209848/letter-from-vietnam
#13
LETTER
Giap Van Vu
No abstract text is available yet for this article.
September 12, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30207018/bronchiectasis-treatment-decisions-for-pulmonary-exacerbations-and-their-prevention
#14
REVIEW
Scott C Bell, Joseph S Elborn, Catherine A Byrnes
Interest in bronchiectasis has increased over the past two decades, as shown by the establishment of disease-specific registries in several countries, the publication of management guidelines and a growing number of clinical trials to address evidence gaps for treatment decisions. This review considers the evidence for defining and treating pulmonary exacerbations, the approaches for eradication of newly identified airway pathogens and the methods to prevent exacerbations through long-term treatments from a pragmatic practice-based perspective...
September 11, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30189465/choosing-the-right-mask-for-your-asian-patient-with-sleep-apnoea-a-randomized-crossover-trial-of-cpap-interfaces
#15
Ken Junyang Goh, Rui Ya Soh, Leong Chai Leow, Song Tar Toh, Pei Rong Song, Ying Hao, Ken Cheah Hooi Lee, Gan Liang Tan, Thun How Ong
BACKGROUND AND OBJECTIVE: A major challenge with the treatment of obstructive sleep apnoea (OSA) is adherence to continuous positive airway pressure (CPAP) therapy. Mask tolerability is an important determinant of adherence, however evidence to guide selection of mask interfaces is lacking. METHODS: We conducted a randomized crossover trial of mask interfaces in CPAP therapy for moderate-to-severe OSA to assess adherence and efficacy of CPAP therapy with nasal mask, nasal pillow and oronasal masks...
September 6, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30189463/drug-resistance-mechanisms-and-drug-susceptibility-testing-for-tuberculosis
#16
REVIEW
Paolo Miotto, Ying Zhang, Daniela Maria Cirillo, Wing Cheong Yam
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is the deadliest infectious disease and the associated global threat has worsened with the emergence of drug resistance, in particular multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). Although the World Health Organization (WHO) End-TB Strategy advocates for universal access to antimicrobial susceptibility testing, this is not widely available and/or it is still underused. The majority of drug resistance in clinical MTB strains is attributed to chromosomal mutations...
September 6, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30187976/bacteriology-and-clinical-outcomes-of-patients-with-culture-positive-pleural-infection-in-western-australia-a-6-year-analysis
#17
Fraser Brims, Natalia Popowicz, Andrew Rosenstengel, Julie Hart, Arthee Yogendran, Catherine A Read, Felicity Lee, Ranjan Shrestha, Alexander Franke, Joshua R Lewis, Ian Kay, Grant Waterer, Y C Gary Lee
BACKGROUND AND OBJECTIVE: Pleural infection is a clinical challenge; its microbiology can be complex. Epidemiological and outcome data of pleural infection in adult Australians are lacking. We describe the bacteriology and clinical outcomes of Australian adults with culture-positive pleural infection (CPPI) over a 6-year period. METHODS: Cases with CPPI were identified through Western Australian public hospitals electronic record. Culture isolates, admission dates, vital status, co-morbidities, radiology, blood and pleural fluid tests were extracted...
September 6, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30183115/driving-pressure-and-acute-respiratory-distress-syndrome-in-critically-ill-patients
#18
Raiko Blondonnet, Elodie Joubert, Thomas Godet, Pauline Berthelin, Thibaut Pranal, Laurence Roszyk, Russell Chabanne, Nathanael Eisenmann, Alexandre Lautrette, Corinne Belville, Sophie Cayot, Thierry Gillart, Bertrand Souweine, Damien Bouvier, Loic Blanchon, Vincent Sapin, Bruno Pereira, Jean-Michel Constantin, Matthieu Jabaudon
BACKGROUND AND OBJECTIVE: Elevated driving pressure (ΔP) may be associated with increased risk of acute respiratory distress syndrome (ARDS) in patients admitted via the emergency department and with post-operative pulmonary complications in surgical patients. This study investigated the association of higher ΔP with the onset of ARDS in a high-risk, intensive care unit (ICU) population. METHODS: This is a secondary analysis of a prospective multicentre observational study...
September 5, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30180305/pulmonary-arterial-hypertension-in-a-multi-ethnic-asian-population-characteristics-survival-and-mortality-predictors-from-a-14-year-follow-up-study
#19
Yinghao Lim, Ting-Ting Low, Siew-Pang Chan, Ting Wei Teo, Jin-Hao Justin Jang, Nicole Yip, Ivandito Kuntjoro, Edgar Lik-Wui Tay, James Wei-Luen Yip
BACKGROUND AND OBJECTIVE: Pulmonary arterial hypertension (PAH) is a rare and fatal disease. Data from Asia are lacking compared with the West. We aim to describe disease characteristics in an ethnically diverse South-East Asian population and assess predictors for survival. METHODS: We consecutively enrolled patients with PAH referred to our pulmonary hypertension specialty centre from January 2003 to December 2016. Baseline characteristics and survival were analysed...
September 4, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/30146773/does-virtual-bronchoscopic-navigation-improve-the-diagnostic-yield-of-transbronchial-biopsy
#20
EDITORIAL
Fumihiro Asano
No abstract text is available yet for this article.
August 26, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
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