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Respirology: Official Journal of the Asian Pacific Society of Respirology

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https://www.readbyqxmd.com/read/28926164/pathogenesis-of-pleural-infection-a-complex-warfare
#1
EDITORIAL
Natalia Popowicz, Steven Idell, Y C Gary Lee
No abstract text is available yet for this article.
September 19, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28925574/radiographic-fibrosis-score-predicts-survival-in-systemic-sclerosis-associated-interstitial-lung-disease
#2
Reoto Takei, Machiko Arita, Shogo Kumagai, Yuhei Ito, Fumiaki Tokioka, Takashi Koyama, Rintaro Saito, Keisuke Nishimura, Hironobu Tokumasu, Tadashi Ishida
BACKGROUND AND OBJECTIVE: Interstitial lung disease (ILD) is a common pulmonary manifestation of systemic sclerosis (SSc). It is unknown whether radiographic fibrosis score predicts mortality in SSc-associated ILD (SSc-ILD). We retrospectively analysed patients with SSc-ILD to evaluate whether radiographic fibrosis score was a useful predictor of mortality. METHODS: We identified SSc-ILD patients evaluated at Kurashiki Central Hospital (Japan) from 2006 to 2016, and radiographic fibrosis scores based on the extent of reticulation and honeycombing on high-resolution computed tomography (HRCT) scanning were calculated by manually tracing around each fibrotic area...
September 19, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28913912/streptococcus-pneumoniae-colonization-of-the-nasopharynx-is-associated-with-increased-severity-during-respiratory-syncytial-virus-infection-in-young-children
#3
Jaelle C Brealey, Keith J Chappell, Sally Galbraith, Emmanuelle Fantino, Jane Gaydon, Sarah Tozer, Paul R Young, Patrick G Holt, Peter D Sly
BACKGROUND AND OBJECTIVE: Respiratory syncytial virus (RSV) is the most significant cause of acute respiratory infection (ARI) in early life. RSV and other respiratory viruses are known to stimulate substantial outgrowth of potentially pathogenic bacteria in the upper airways of young children. However, the clinical significance of interactions between viruses and bacteria is currently unclear. The present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric ARI...
September 15, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28913877/minimal-important-difference-of-target-lobar-volume-reduction-after-endobronchial-valve-treatment-for-emphysema
#4
Jorrit B A Welling, Jorine E Hartman, Eva M van Rikxoort, Nick H T Ten Hacken, Huib A M Kerstjens, Karin Klooster, Dirk-Jan Slebos
BACKGROUND AND OBJECTIVE: Target lobar volume reduction (TLVR) is an important efficacy outcome measure for bronchoscopic lung volume reduction (BLVR) treatment using one-way endobronchial valves (EBV) in patients with severe emphysema. The commonly used cut-off value for TLVR that expresses a perceivable clinical benefit is -350 mL. However, a scientifically determined minimal important difference (MID) for TLVR never has been published. The objective of the present study was to determine the MID for TLVR on HRCT in patients who were treated with EBV...
September 15, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28906034/small-airway-disease-a-different-phenotype-of-early-stage-copd-associated-with-biomass-smoke-exposure
#5
Dongxing Zhao, Yumin Zhou, Changbin Jiang, Zhuxiang Zhao, Fang He, Pixin Ran
BACKGROUND AND OBJECTIVE: Chronic exposure to biomass smoke (BS) can significantly compromise pulmonary function and lead to chronic obstructive pulmonary disease (COPD). To determine whether BS exposure induces a unique phenotype of COPD from an early stage, with different physiopathological features compared with COPD associated with smoking (cigarette-smoke (CS) COPD), we assessed the physiopathology of early COPD associated with BS exposure (BS COPD) by incorporating spirometry, high-resolution computed tomography (HRCT) imaging, bronchoscopy and pathological examinations...
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28905522/inclusion-of-sepsis-and-hypoxaemia-in-mortality-prediction-of-hospitalized-patients-with-community-acquired-pneumonia-reply
#6
LETTER
Stefan M T Vestjens, Simone M C Spoorenberg, Ewoudt M W van de Garde, Willem Jan W Bos
No abstract text is available yet for this article.
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28905471/novel-assessment-tool-to-detect-breathing-pattern-disorder-in-patients-with-refractory-asthma
#7
Sarah Todd, Emil S Walsted, Lizzie Grillo, Rebecca Livingston, Andrew Menzies-Gow, James H Hull
BACKGROUND AND OBJECTIVE: Breathing pattern disorder (BPD) can co-exist with and mimic asthma, acting to amplify symptoms and confound assessment of disease control, resulting in inappropriate treatment escalation. The aim of this research was to report the utility of a novel breathing pattern assessment tool (BPAT) to detect BPD in treatment-refractory asthma. METHODS: As a component of a multidisciplinary assessment, adult patients referred with treatment-refractory asthma underwent respiratory physiotherapy assessment to diagnose BPD...
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28905465/inclusion-of-sepsis-and-hypoxaemia-in-mortality-prediction-of-hospitalized-patients-with-community-acquired-pneumonia
#8
LETTER
Huriye Berk Takir, Antonio M Esquinas, Alastair J Glossop
No abstract text is available yet for this article.
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28905464/urinary-desmosine-is-associated-with-emphysema-severity-and-frequent-exacerbation-in-patients-with-copd
#9
Changhwan Kim, Yousang Ko, Su Hee Kim, Hyun Ju Yoo, Jae Seung Lee, Chin Kook Rhee, Jin Hwa Lee, Ji-Hyun Lee, Tae-Hyung Kim, Seong Yong Lim, Kwang Ha Yoo, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Yong Bum Park
BACKGROUND AND OBJECTIVE: Matrix degradation is a key feature of chronic obstructive pulmonary disease (COPD). Desmosine and isodesmosine (desmosines) are excreted in urine following matrix degradation. The main purpose of this study was to investigate the association between computed tomography (CT) emphysema indices and urinary desmosines in patients with COPD. METHODS: A total of 152 subjects were selected from the Korean Obstructive Lung Disease cohort. Their urine samples were assayed for desmosines using liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods...
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28905459/rescue-therapy-within-the-uk-cystic-fibrosis-registry-an-exploration-of-predictors-of-intravenous-antibiotic-use-amongst-adults-with-cf
#10
Zhe Hui Hoo, Martin J Wildman, Rachael Curley, Stephen J Walters, Michael J Campbell
BACKGROUND AND OBJECTIVE: Intravenous (i.v.) antibiotics are needed for rescue when preventative therapy fails to achieve stability among adults with cystic fibrosis (CF). Understanding the distribution of i.v. days can provide insight into the care that adults with CF need. We aim to determine the baseline characteristics that are associated with higher i.v. use, in particular to test the hypothesis that prior-year i.v. use is associated with future-year i.v. use. METHODS: This is a cross-sectional analysis of the 2013-2014 UK CF registry data...
September 14, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28901032/role-of-routine-post-operative-laryngeal-endoscopic-assessment-after-lung-cancer-surgery
#11
EDITORIAL
Chong-Kin Liam
No abstract text is available yet for this article.
September 12, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28901030/treating-osa-current-and-emerging-therapies-beyond-cpap
#12
REVIEW
Geraldo Lorenzi-Filho, Fernanda R Almeida, Patrick J Strollo
Continuous positive airway pressure (CPAP) is the standard treatment for moderate-to-severe obstructive sleep apnoea (OSA). However, adherence to CPAP is limited and non-CPAP therapies are frequently explored. Oral appliance (OA) therapy is currently widely used for the treatment of snoring, mild, moderate and severe OSA. The most commonly used and studied OA consists of a maxillary and mandibular splint which hold the lower jaw forward during sleep. The efficacy of OA is inferior to CPAP; however, the effectiveness as measured by sleepiness, quality of life, endothelial function and blood pressure is similar likely due to higher acceptance and subjective adherence...
September 12, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28891101/the-interstitial-lung-disease-multidisciplinary-meeting-a-position-statement-from-the-thoracic-society-of-australia-and-new-zealand-and-the-lung-foundation-australia
#13
Jyotika D Prasad, Annabelle Mahar, Jane Bleasel, Samantha J Ellis, Daniel C Chambers, Fiona Lake, Peter M A Hopkins, Tamera J Corte, Heather Allan, Ian N Glaspole
Interstitial lung diseases (ILD) are a diverse group of pulmonary diseases for which accurate diagnosis is critical for optimal treatment outcomes. Diagnosis of ILD can be challenging and a multidisciplinary approach is recommended in international guidelines. The purpose of this position paper is to review the evidence for the use of the multidisciplinary meeting (MDM) in ILD and suggest an approach to its governance and constitution, in an attempt to provide a standard methodology that could be applied across Australia and New Zealand...
September 10, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28857370/refining-the-role-of-endobronchial-ultrasound-transbronchial-needle-aspiration-in-lung-cancer-staging
#14
EDITORIAL
Phan Nguyen
No abstract text is available yet for this article.
August 30, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28857362/diagnostic-performance-of-endobronchial-ultrasound-guided-mediastinal-lymph-node-sampling-in-early-stage-non-small-cell-lung-cancer-a-prospective-study
#15
Macarena R Vial, Oisin J O'Connell, Horiana B Grosu, Mike Hernandez, Laila Noor, Roberto F Casal, John Stewart, Mona Sarkiss, Carlos A Jimenez, David Rice, Reza Mehran, David E Ost, George A Eapen
BACKGROUND AND OBJECTIVE: Standard nodal staging of lung cancer consists of positron emission tomography/computed tomography (PET/CT), followed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) if PET/CT shows mediastinal lymphadenopathy. Sensitivity of EBUS-TBNA in patients with N0/N1 disease by PET/CT is unclear and largely based on retrospective studies. We assessed the sensitivity of EBUS-TBNA in this setting. METHODS: We enrolled patients with proven or suspected lung cancer staged as N0/N1 by PET/CT and without metastatic disease (M0), who underwent staging EBUS-TBNA...
August 30, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28851038/hypersensitivity-pneumonitis-a-protean-and-challenging-disease
#16
EDITORIAL
Adelle S Jee, Helen E Jo, Tamera J Corte
No abstract text is available yet for this article.
August 29, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28851013/body-size-adjusted-dose-analysis-of-pirfenidone-in-patients-with-interstitial-pneumonia
#17
Masahiro Uehara, Noriyuki Enomoto, Yoshiyuki Oyama, Yuzo Suzuki, Masato Kono, Kazuki Furuhashi, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Takafumi Suda
BACKGROUND AND OBJECTIVE: Pirfenidone is an effective anti-fibrotic agent for idiopathic pulmonary fibrosis (IPF). Although adverse events (AE) sometimes prevent patients from continuing treatment, current dose adjustment guidance does not consider patient body size or weight (BW). The aim of this study was to evaluate the importance of pirfenidone dose adjustment by body surface area (BSA) or BW for preventing AE and permitting continuous treatment in patients with interstitial pneumonia (IP)...
August 29, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28850767/recent-controversies-about-mdr-and-xdr-tb-global-implementation-of-the-who-shorter-mdr-tb-regimen-and-bedaquiline-for-all-with-mdr-tb
#18
REVIEW
Keertan Dheda, Helen Cox, Aliasgar Esmail, Sean Wasserman, Kwok Chiu Chang, Christoph Lange
Tuberculosis (TB) is now the biggest infectious disease killer worldwide. Although the estimated incidence of TB has marginally declined over several years, it is out of control in some regions including in Africa. The advent of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) threatens to further destabilize control in several regions of the world. Drug-resistant TB constitutes a significant threat because it underpins almost 25% of global TB mortality, is associated with high morbidity, is a threat to healthcare workers and is unsustainably costly to treat...
August 29, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28845601/asthma-prescribing-where-are-we-headed
#19
EDITORIAL
Richard Beasley, Jo Hardy, Robert Hancox
No abstract text is available yet for this article.
August 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28845582/pathophysiology-of-exercise-intolerance-in-pulmonary-arterial-hypertension
#20
REVIEW
Derek L Tran, Edmund M T Lau, David S Celermajer, Glen M Davis, Rachael Cordina
Pulmonary arterial hypertension (PAH) is a chronic disease with poor prognosis and important exercise limitation despite the proliferation of treatment options in the last decade. Chronically increased right ventricular (RV) afterload results in right heart failure and without treatment, rapid clinical deterioration is common. Exercise intolerance is the cardinal feature of the disease impacting upon quality of life and clinical outcome. The pathophysiological mechanisms that lead to reduced exercise capacity in this population are complex with ventriculoarterial uncoupling likely to be the predominant feature...
August 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
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