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Journal of Biological Inorganic Chemistry: JBIC

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https://www.readbyqxmd.com/read/28801867/regulation-of-the-aggregation-behavior-of-human-islet-amyloid-polypeptide-fragment-by-titanocene-complexes
#1
Weihong Du, Gehui Gong, Wenji Wang, Jufei Xu
The aggregation of human islet amyloid polypeptide (hIAPP) is associated with type II diabetes. The misfolding of hIAPP induces amyloid deposition and causes β-cell dysfunction. Metal complexes are potential metallodrugs that may reverse the aggregation of amyloid peptides. hIAPP19-37 is a crucial fragment of the full-length hIAPP1-37 and contains typical aromatic residues and a core hydrophobic region. In this work, we studied the effects of titanocene complexes titanocene dichloride (1), titanocene salicylic acid complex (2), and titanocene methionine complex (3) on the aggregation behavior of hIAPP19-37...
August 11, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28779308/anticancer-activity-of-novel-amino-acid-derivative-of-palladium-complex-with-phendione-ligand-against-of-human-colon-cancer-cell-line
#2
Hossein Farhangian, Mahboube Eslami Moghadam, Adeleh Divsalar, Arezo Rahiminezhad
The aim of this work is the identification of the structural effect of amino acid-Pd complex on DNA as an intracellular target which was studied using various spectroscopic techniques such as fluorescence, UV-visible and circular dichroism in combination with a molecular docking study. Hence, a novel water-soluble palladium complex, [Pd(phendione)(isopentylglycine)]NO3, has been synthesized and characterized by spectroscopic method. The anticancer activity of complex was investigated against human colon cancer cell line of HCT116 after 24 h of incubation using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay...
August 4, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28748309/interaction-of-zn-ii-bleomycin-a2-and-zn-ii-peplomycin-with-a-dna-hairpin-containing-the-5-gt-3-binding-site-in-comparison-with-the-5-gc-3-binding-site-studied-by-nmr-spectroscopy
#3
Shelby E Follett, Azure D Ingersoll, Sally A Murray, Teresa M Reilly, Teresa E Lehmann
Bleomycins are a group of glycopeptide antibiotics synthesized by Streptomyces verticillus that are widely used for the treatment of various neoplastic diseases. These antibiotics have the ability to chelate a metal center, mainly Fe(II), and cause site-specific DNA cleavage. Bleomycins are differentiated by their C-terminal regions. Although this antibiotic family is a successful course of treatment for some types of cancers, it is known to cause pulmonary fibrosis. Previous studies have identified that bleomycin-related pulmonary toxicity is linked to the C-terminal region of these drugs...
July 26, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28721666/erratum-to-vosalophen-a-vanadium-complex-with-a-stilbene-derivative-induction-of-apoptosis-autophagy-and-efficiency-in-experimental-cutaneous-leishmaniasis
#4
Patrícia de A Machado, Jessica O F Moraes, Gustavo S G Carvalho, Wallace P Lima, Gilson C Macedo, Elizandra A Britta, Celso V Nakamura, Adilson D da Silva, Alexandre Cuin, Elaine S Coimbra
No abstract text is available yet for this article.
July 18, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28702751/complexes-of-gastrin-with-in-3-ru-3-or-ga-3-ions-are-not-recognised-by-the-cholecystokinin-2-receptor
#5
Marie Laval, Kathryn M Marshall, John Sachinidis, Andrew Scott, Mal Eutick, Graham S Baldwin
The peptide hormone gastrin (Gamide) binds trivalent metal ions, including indium (In), ruthenium (Ru) and gallium (Ga), with high affinity. Complexes of gastrin with chelated isotopes of In and Ga have previously been used for the location of tumours expressing the cholecystokinin 2 receptor (CCK2R). The aim of the present study was to purify the complexes of Gamide with radioactive isotopes of In, Ru or Ga and to investigate their ability to bind to the CCK2R. The radioactive Gamide complexes were purified on Sep-Pak C18 cartridges or by anion exchange HPLC...
July 12, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28698982/targeting-the-reactive-intermediate-in-polysaccharide-monooxygenases
#6
Erik D Hedegård, Ulf Ryde
Lytic polysaccharide monooxygenases (LPMOs) are copper metalloenzymes that can enhance polysaccharide depolymerization through an oxidative mechanism, making them interesting for the production of biofuel from cellulose. However, the details of this activation are unknown; in particular, the nature of the intermediate that attacks the glycoside C-H bond in the polysaccharide is not known, and a number of different species have been suggested. The homolytic bond-dissociation energy (BDE) has often been used as a descriptor for the bond-activation power, especially for inorganic model complexes...
July 11, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28695374/impact-of-aromaticity-on-anticancer-activity-of-polypyridyl-ruthenium-ii-complexes-synthesis-structure-dna-protein-binding-lipophilicity-and-anticancer-activity
#7
Petar Čanović, Ana Rilak Simović, Snežana Radisavljević, Ioannis Bratsos, Nicola Demitri, Marina Mitrović, Ivanka Zelen, Živadin D Bugarčić
With the aim of assessing how the aromaticity of the inert chelating ligand can influence the activity of ruthenium(II) polypyridyl complexes, two new monofunctional ruthenium(II) complexes, [Ru(Cl-Ph-tpy)(phen)Cl]Cl (1) and [Ru(Cl-Ph-tpy)(o-bqdi)Cl]Cl (2) (where Cl-Ph-tpy = 4'-(4-chlorophenyl)-2,2':6',2″-terpyridine, phen = 1,10-phenanthroline, o-bqdi = o-benzoquinonediimine), were synthesized. All complexes were fully characterized by elemental analysis and spectroscopic techniques (IR, UV-Vis, 1D and 2D NMR, XRD)...
July 10, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28667369/dft-studies-of-the-substituent-effects-of-dimethylamino-on-non-heme-active-oxidizing-species-iron-v-oxo-species-or-iron-iv-oxo-acetate-aminopyridine-cation-radical-species
#8
Fang Wang, Wei Sun, Chungu Xia, Yong Wang
Through the introduction of dimethylamino (Me2N) substituent at the pyridine ring of 2-((R)-2-[(R)-1-(pyridine-2-ylmethyl)pyrrolidin-2-yl]pyrrolidin-1-ylmethyl)pyridine (PDP) ligand, the non-heme Fe(II)((Me2N)PDP)/H2O2/AcOH catalyst system was found to exhibit significant higher catalytic activity and enantioselectivity than the non-substituent one in the asymmetric epoxidation experiments. The mechanistic origin of the remarkable substituent effects in these oxidation reactions has not been well established...
June 30, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28577166/8th-asian-biological-inorganic-chemistry-conference
#9
EDITORIAL
Christian G Hartinger
No abstract text is available yet for this article.
June 2, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28646425/hydroxylamine-induced-oxidation-of-ferrous-carbonylated-truncated-hemoglobins-from-mycobacterium-tuberculosis-and-campylobacter-jejuni-is-limited-by-carbon-monoxide-dissociation
#10
Paolo Ascenzi, Chiara Ciaccio, Tecla Gasperi, Alessandra Pesce, Lucia Caporaso, Massimo Coletta
Hydroxylamine (HA) is an oxidant of ferrous globins and its action has been reported to be inhibited by CO, even though this mechanism has not been clarified. Here, kinetics of the HA-mediated oxidation of ferrous carbonylated Mycobacterium tuberculosis truncated hemoglobin N and O (Mt-trHbN(II)-CO and Mt-trHbO(II)-CO, respectively) and Campylobacter jejuni truncated hemoglobin P (Cj-trHbP(II)-CO), at pH 7.2 and 20.0 °C, are reported. Mixing Mt-trHbN(II)-CO, Mt-trHbO(II)-CO, and Cj-trHbP(II)-CO solution with the HA solution brings about absorption spectral changes reflecting the disappearance of the ferrous carbonylated derivatives with the concomitant formation of the ferric species...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28643149/surface-modification-minimizes-the-toxicity-of-silver-nanoparticles-an-in-vitro-and-in-vivo-study
#11
Balaram Das, Satyajit Tripathy, Jaydeep Adhikary, Sourav Chattopadhyay, Debasis Mandal, Sandeep Kumar Dash, Sabyasachi Das, Aditi Dey, Sankar Kumar Dey, Debasis Das, Somenath Roy
Currently toxicological research in Silver nanoparticle is a leading issue in medical science. The surface chemistry and physical dimensions of silver nanoparticles (Ag-NPs) play an important role in toxicity. The aim of this present study was to evaluate the in vitro and in vivo toxicity of Ag-NPs as well as the alteration of toxicity profile due to surface functionalization (PEG and BSA) and the intracellular signaling pathways involved in nanoparticles mediated oxidative stress and apoptosis in vitro and in vivo system...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28639057/factors-controlling-the-reactivity-of-divalent-metal-ions-towards-pheophytin-a
#12
Ł Orzeł, J Waś, A Kania, A Susz, D Rutkowska-Zbik, J Staroń, M Witko, G Stochel, L Fiedor
In this study, we evaluate the factors which determine the reactivity of divalent metal ions in the spontaneous formation of metallochlorophylls, using experimental and computational approaches. Kinetic studies were carried out using pheophytin a in reactions with various divalent metal ions combined with non- or weakly-coordinative counter ions in a series of organic solvents. To obtain detailed insights into the solvent effect, the metalations with the whole set of cations were investigated in three solvents and with Zn(2+) in seven solvents...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28620693/comparative-studies-of-reaction-of-cobalamin-ii-and-cobinamide-ii-with-sulfur-dioxide
#13
Ilia A Dereven'kov, Pavel A Ivlev, Cristina Bischin, Denis S Salnikov, Radu Silaghi-Dumitrescu, Sergei V Makarov, Oscar I Koifman
The kinetics of reactions of cobalamin (II) and cobinamide (II) with sulfur dioxide was studied by UV-visible (UV-vis) spectroscopy. Reaction results in oxidation of Co(II) center and involves two aquated SO2 moieties. The final product is suggested to be complex Co(III)-S2O 4(•-) . The absence of corrin ring modifications during the reactions was proved.
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28616663/the-water-soluble-axially-disubstituted-silicon-phthalocyanines-photophysicochemical-properties-and-in-vitro-studies
#14
Meltem Göksel, Zekeriya Biyiklioglu, Mahmut Durmuş
Two novel silicon(IV) phthalocyanines bearing 1,3-bis[3(dimethylamino)phenoxy]propan-2-ol or 1,3-bis[3(diethylamino)phenoxy]propan-2-ol groups at their axial positions were synthesized. These phthalocyanines were converted into their water soluble derivatives by the quaternization reaction with methyl iodide. The quaternized phthalocyanines show excellent solubility aqueous solutions without any aggregation which makes them potential photosensitizers for use in photodynamic therapy (PDT). For this reason, the photophysical and photochemical properties such as fluorescence quantum yields, lifetimes, singlet oxygen generation and photodegradation of both non-ionic (3 and 5) and quaternized cationic silicon(IV) phthalocyanines were investigated...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28597089/vosalophen-a-vanadium-complex-with-a-stilbene-derivative-induction-of-apoptosis-autophagy-and-efficiency-in-experimental-cutaneous-leishmaniasis
#15
Patrícia de A Machado, Jessica O F Morais, Gustavo S G Carvalho, Wallace P Lima, Gilson C Macedo, Elizandra A Britta, Celso V Nakamura, Adilson D da Silva, Alexandre Cuin, Elaine S Coimbra
In our previous work, we demonstrated the promising in vitro effect of VOSalophen, a vanadium complex with a stilbene derivative, against Leishmania amazonensis. Its antileishmanial activity has been associated with oxidative stress in L. amazonensis promastigotes and L. amazonensis-infected macrophages. In the present study, the mechanism involved in the death of parasites after treatment with VOSalophen, as well as in vivo effect in the murine model cutaneous leishmaniasis, has been investigated. Promastigotes of L...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28584975/crystal-structure-and-functional-analysis-of-leishmania-major-pseudoperoxidase
#16
Georges Chreifi, Dillon Dejam, Thomas L Poulos
Leishmania major pseudoperoxidase (LmPP) is a recently discovered heme protein expressed by the human pathogen. Previous in vivo and in vitro studies suggest that LmPP is a crucial element of the pathogen's defense mechanism against the reactive nitrogen species peroxynitrite produced during the host immune response. To shed light on the potential mechanism of peroxynitrite detoxification, we have determined the 1.76-Å X-ray crystal structure of LmPP, revealing a striking degree of homology with heme peroxidases...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28516215/are-clinical-findings-of-systemic-titanium-dispersion-following-implantation-explained-by-available-in-vitro-evidence-an-evidence-based-analysis
#17
REVIEW
Justin Paul Curtin, Minji Wang
Although the presence of titanium wear particles released into tissues is known to induce local inflammation following the therapeutic implantation of titanium devices into humans, the role that titanium ions play in adverse tissue responses has received little attention. Support that ongoing titanium ion release occurs is evidenced by the presence of ionic titanium bound to transferrin in blood, and ongoing excretion in the urine of patients with titanium devices. However, as reports documenting the presence of titanium within tissues do not distinguish between particulate and ionic forms due to technical challenges, the degree to which ionic titanium is released into tissues is unknown...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28509989/the-dna-sequence-specificity-of-bleomycin-cleavage-in-a-systematically-altered-dna-sequence
#18
Shweta D Gautam, Jon K Chen, Vincent Murray
Bleomycin is an anti-tumour agent that is clinically used to treat several types of cancers. Bleomycin cleaves DNA at specific DNA sequences and recent genome-wide DNA sequencing specificity data indicated that the sequence 5'-RTGT*AY (where T* is the site of bleomycin cleavage, R is G/A and Y is T/C) is preferentially cleaved by bleomycin in human cells. Based on this DNA sequence, we constructed a plasmid clone to explore this bleomycin cleavage preference. By systematic variation of single nucleotides in the 5'-RTGT*AY sequence, we were able to investigate the effect of nucleotide changes on bleomycin cleavage efficiency...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28508949/zn-ii-dipicolylamine-based-metallo-lipids-as-novel-non-viral-gene-vectors
#19
Rong-Chuan Su, Qiang Liu, Wen-Jing Yi, Zhi-Gang Zhao
In this study, a series of Zn(II)-dipicolylamine (Zn-DPA) based cationic lipids bearing different hydrophobic tails (long chains, α-tocopherol, cholesterol or diosgenin) were synthesized. Structure-activity relationship (SAR) of these lipids was studied in detail by investigating the effects of several structural aspects including the type of hydrophobic tails, the chain length and saturation degree. In addition, several assays were used to study their interactions with plasmid DNA, and results reveal that these lipids could condense DNA into nanosized particles with appropriate size and zeta-potentials...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28502066/ebselen-ameliorates-%C3%AE-amyloid-pathology-tau-pathology-and-cognitive-impairment-in-triple-transgenic-alzheimer-s-disease-mice
#20
Yongli Xie, Yibin Tan, Youbiao Zheng, Xiubo Du, Qiong Liu
Alzheimer's disease (AD) is a progressive neurodegenerative disease which is clinically characterized by memory loss and cognitive decline caused by protein misfolding and aggregation. Imbalance between free radicals and the antioxidant system is a prominent and early feature in the neuropathology of AD. Selenium (Se), a vital trace element with excellent antioxidant potential, is preferentially retained in the brain in Se-limited conditions and has been reported to provide neuroprotection through resisting oxidative damage...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
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