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Journal of Biological Inorganic Chemistry: JBIC

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https://www.readbyqxmd.com/read/28924921/mg-2-induced-dna-compaction-condensation-and-phase-separation-in-gene-delivery-vehicles-based-on-zwitterionic-phospholipids-a-dynamic-light-scattering-and-surface-enhanced-raman-spectroscopic-study
#1
Erhan Süleymanoğlu
Despite the significant efforts towards applying improved non-destructive and label-free measurements of biomolecular structures of lipid-based gene delivery vectors, little is achieved in terms of their structural relevance in gene transfections. Better understanding of structure-activity relationships of lipid-DNA complexes and their gene expression efficiencies thus becomes an essential issue. Raman scattering offers a complimentary measurement technique for following the structural transitions of both DNA and lipid vesicles employed for their transfer...
September 18, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28913669/resolving-distinct-molecular-origins-for-copper-effects-on-pai-1
#2
Joel C Bucci, Carlee S McClintock, Yuzhuo Chu, Gregory L Ware, Kayla D McConnell, Joseph P Emerson, Cynthia B Peterson
Components of the fibrinolytic system are subjected to stringent control to maintain proper hemostasis. Central to this regulation is the serpin plasminogen activator inhibitor-1 (PAI-1), which is responsible for specific and rapid inhibition of fibrinolytic proteases. Active PAI-1 is inherently unstable and readily converts to a latent, inactive form. The binding of vitronectin and other ligands influences stability of active PAI-1. Our laboratory recently observed reciprocal effects on the stability of active PAI-1 in the presence of transition metals, such as copper, depending on the whether vitronectin was also present (Thompson et al...
September 14, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28884428/in-vitro-and-in-vivo-anti-proliferative-evaluation-of-bis-4-4-tolyl-2-2-6-2%C3%A2-terpyridine-copper-ii-complex-against-ehrlich-ascites-carcinoma-tumors
#3
Dharmasivam Mahendiran, Raju Senthil Kumar, Vijayan Viswanathan, Devadasan Velmurugan, Aziz Kalilur Rahiman
The bis(4'-(4-tolyl)-2,2':6',2″-terpyridine)copper(II) complex [Cu(ttpy)2]Cl2 was synthesized and authenticated by single crystal analysis, which shows distorted octahedral geometry around copper(II) ion. The crystal packing is stabilized by C-H···π inter and intramolecular interactions. The complex was found to be lipophilic as determined by shake-flask method. In vitro cytotoxicity of the complex was tested against Ehrlich ascites carcinoma (EAC) and L6 myotube cell lines. The complex exhibit potent cytotoxicity with respect to the commercially available anticancer drug cisplatin...
September 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28884403/resonance-raman-studies-on-the-flavohemoglobin-of-the-protist-giardia-intestinalis-evidence-of-a-type-i-ii-peroxidase-like-heme-environment-and-roles-of-the-active-site-distal-residues
#4
Brian Lukaszewicz, Eliza McColl, Janet Yee, Steven Rafferty, Manon Couture
Flavohemoglobins are microbial enzymes that counter nitrosative stress, but the details of their underlying enzymatic activities and structure-function relationships are not completely understood. These enzymes have been identified in Gram-negative bacteria, certain fungi, and the parasitic protist Giardia intestinalis (gFlHb) which, despite lacking the ability to make heme, encodes several hemeproteins. To gain knowledge about the biophysical properties of the active site of gFlHb, we used resonance Raman spectroscopy to probe the wild-type protein and variants at globin domain positions E11, E7, and B10 on the distal, ligand-binding side of the heme...
September 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28866736/peroxynitrite-scavenging-by-campylobacter-jejuni-truncated-hemoglobin-p
#5
Paolo Ascenzi, Alessandra Pesce
Truncated hemoglobins (trHb) are present in protozoa, cyanobacteria, nemertean, bacteria, algae, and plants. They are characterized by the 2-on-2 topology and are ordered in four phylogenetic groups (I or N, II or O, III or P, and IV or Q). Several functions have been attributed to trHbs including the inactivation of reactive nitrogen and oxygen species, permitting the survival of microorganisms in the host. Here, the kinetics of peroxynitrite scavenging by ferric Campylobacter jejuni truncated hemoglobin P [i...
September 2, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28865047/facile-synthesis-of-gd-doped-cdte-quantum-dots-with-optimized-properties-for-optical-mr-multimodal-imaging
#6
Zizhen Li, Ali Dergham, Holly McCulloch, Yubo Qin, Xiuying Yang, Jingchang Zhang, Xudong Cao
Each imaging modality has its own merits and intrinsic limitations; therefore, combining two or more complementary imaging modalities has become an interesting area of research. Recently, magnetic ion-doped quantum dots have become an increasingly promising class of optical/magnetic resonance multimodal imaging probes due to their excellent physical and chemical properties. In this work, Gd-doped CdTe quantum dots (QDs) were successfully synthesized via a facile one-step refluxing route,and their optimal synthesis conditions were investigated...
September 1, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28836015/role-of-protein-glutathione-contacts-in-defining-glutaredoxin-3-2fe-2s-cluster-chirality-ligand-exchange-and-transfer-chemistry
#7
Sambuddha Sen, J A Cowan
Monothiol glutaredoxins (Grx) serve as intermediate cluster carriers in iron-sulfur cluster trafficking. The [2Fe-2S]-bound holo forms of Grx proteins display cysteinyl coordination from exogenous glutathione (GSH), in addition to contact from protein-derived Cys. Herein, we report mechanistic studies that investigate the role of exogenous glutathione in defining cluster chirality, ligand exchange, and the cluster transfer chemistry of Saccharomyces cerevisiae Grx3. Systematic perturbations were introduced to the glutathione-binding site by substitution of conserved charged amino acids that form crucial electrostatic contacts with the glutathione molecule...
August 23, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28825148/crystal-structures-reveal-metal-binding-plasticity-at-the-metallo-%C3%AE-lactamase-active-site-of-pqqb-from-pseudomonas-putida
#8
Xiongying Tu, John A Latham, Valerie J Klema, Robert L Evans, Chao Li, Judith P Klinman, Carrie M Wilmot
PqqB is an enzyme involved in the biosynthesis of pyrroloquinoline quinone and a distal member of the metallo-β-lactamase (MBL) superfamily. PqqB lacks two residues in the conserved signature motif HxHxDH that makes up the key metal-chelating elements that can bind up to two metal ions at the active site of MBLs and other members of its superfamily. Here, we report crystal structures of PqqB bound to Mn(2+), Mg(2+), Cu(2+), and Zn(2+). These structures demonstrate that PqqB can still bind metal ions at the canonical MBL active site...
August 19, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28801867/regulation-of-the-aggregation-behavior-of-human-islet-amyloid-polypeptide-fragment-by-titanocene-complexes
#9
Weihong Du, Gehui Gong, Wenji Wang, Jufei Xu
The aggregation of human islet amyloid polypeptide (hIAPP) is associated with type II diabetes. The misfolding of hIAPP induces amyloid deposition and causes β-cell dysfunction. Metal complexes are potential metallodrugs that may reverse the aggregation of amyloid peptides. hIAPP19-37 is a crucial fragment of the full-length hIAPP1-37 and contains typical aromatic residues and a core hydrophobic region. In this work, we studied the effects of titanocene complexes titanocene dichloride (1), titanocene salicylic acid complex (2), and titanocene methionine complex (3) on the aggregation behavior of hIAPP19-37...
August 11, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28779308/anticancer-activity-of-novel-amino-acid-derivative-of-palladium-complex-with-phendione-ligand-against-of-human-colon-cancer-cell-line
#10
Hossein Farhangian, Mahboube Eslami Moghadam, Adeleh Divsalar, Arezo Rahiminezhad
The aim of this work is the identification of the structural effect of amino acid-Pd complex on DNA as an intracellular target which was studied using various spectroscopic techniques such as fluorescence, UV-visible and circular dichroism in combination with a molecular docking study. Hence, a novel water-soluble palladium complex, [Pd(phendione)(isopentylglycine)]NO3, has been synthesized and characterized by spectroscopic method. The anticancer activity of complex was investigated against human colon cancer cell line of HCT116 after 24 h of incubation using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay...
August 4, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28748309/interaction-of-zn-ii-bleomycin-a2-and-zn-ii-peplomycin-with-a-dna-hairpin-containing-the-5-gt-3-binding-site-in-comparison-with-the-5-gc-3-binding-site-studied-by-nmr-spectroscopy
#11
Shelby E Follett, Azure D Ingersoll, Sally A Murray, Teresa M Reilly, Teresa E Lehmann
Bleomycins are a group of glycopeptide antibiotics synthesized by Streptomyces verticillus that are widely used for the treatment of various neoplastic diseases. These antibiotics have the ability to chelate a metal center, mainly Fe(II), and cause site-specific DNA cleavage. Bleomycins are differentiated by their C-terminal regions. Although this antibiotic family is a successful course of treatment for some types of cancers, it is known to cause pulmonary fibrosis. Previous studies have identified that bleomycin-related pulmonary toxicity is linked to the C-terminal region of these drugs...
July 26, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28721666/erratum-to-vosalophen-a-vanadium-complex-with-a-stilbene-derivative-induction-of-apoptosis-autophagy-and-efficiency-in-experimental-cutaneous-leishmaniasis
#12
Patrícia de A Machado, Jessica O F Moraes, Gustavo S G Carvalho, Wallace P Lima, Gilson C Macedo, Elizandra A Britta, Celso V Nakamura, Adilson D da Silva, Alexandre Cuin, Elaine S Coimbra
No abstract text is available yet for this article.
July 18, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28702751/complexes-of-gastrin-with-in-3-ru-3-or-ga-3-ions-are-not-recognised-by-the-cholecystokinin-2-receptor
#13
Marie Laval, Kathryn M Marshall, John Sachinidis, Andrew Scott, Mal Eutick, Graham S Baldwin
The peptide hormone gastrin (Gamide) binds trivalent metal ions, including indium (In), ruthenium (Ru) and gallium (Ga), with high affinity. Complexes of gastrin with chelated isotopes of In and Ga have previously been used for the location of tumours expressing the cholecystokinin 2 receptor (CCK2R). The aim of the present study was to purify the complexes of Gamide with radioactive isotopes of In, Ru or Ga and to investigate their ability to bind to the CCK2R. The radioactive Gamide complexes were purified on Sep-Pak C18 cartridges or by anion exchange HPLC...
July 12, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28698982/targeting-the-reactive-intermediate-in-polysaccharide-monooxygenases
#14
Erik D Hedegård, Ulf Ryde
Lytic polysaccharide monooxygenases (LPMOs) are copper metalloenzymes that can enhance polysaccharide depolymerization through an oxidative mechanism, making them interesting for the production of biofuel from cellulose. However, the details of this activation are unknown; in particular, the nature of the intermediate that attacks the glycoside C-H bond in the polysaccharide is not known, and a number of different species have been suggested. The homolytic bond-dissociation energy (BDE) has often been used as a descriptor for the bond-activation power, especially for inorganic model complexes...
July 11, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28695374/impact-of-aromaticity-on-anticancer-activity-of-polypyridyl-ruthenium-ii-complexes-synthesis-structure-dna-protein-binding-lipophilicity-and-anticancer-activity
#15
Petar Čanović, Ana Rilak Simović, Snežana Radisavljević, Ioannis Bratsos, Nicola Demitri, Marina Mitrović, Ivanka Zelen, Živadin D Bugarčić
With the aim of assessing how the aromaticity of the inert chelating ligand can influence the activity of ruthenium(II) polypyridyl complexes, two new monofunctional ruthenium(II) complexes, [Ru(Cl-Ph-tpy)(phen)Cl]Cl (1) and [Ru(Cl-Ph-tpy)(o-bqdi)Cl]Cl (2) (where Cl-Ph-tpy = 4'-(4-chlorophenyl)-2,2':6',2″-terpyridine, phen = 1,10-phenanthroline, o-bqdi = o-benzoquinonediimine), were synthesized. All complexes were fully characterized by elemental analysis and spectroscopic techniques (IR, UV-Vis, 1D and 2D NMR, XRD)...
July 10, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28667369/dft-studies-of-the-substituent-effects-of-dimethylamino-on-non-heme-active-oxidizing-species-iron-v-oxo-species-or-iron-iv-oxo-acetate-aminopyridine-cation-radical-species
#16
Fang Wang, Wei Sun, Chungu Xia, Yong Wang
Through the introduction of dimethylamino (Me2N) substituent at the pyridine ring of 2-((R)-2-[(R)-1-(pyridine-2-ylmethyl)pyrrolidin-2-yl]pyrrolidin-1-ylmethyl)pyridine (PDP) ligand, the non-heme Fe(II)((Me2N)PDP)/H2O2/AcOH catalyst system was found to exhibit significant higher catalytic activity and enantioselectivity than the non-substituent one in the asymmetric epoxidation experiments. The mechanistic origin of the remarkable substituent effects in these oxidation reactions has not been well established...
June 30, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28646425/hydroxylamine-induced-oxidation-of-ferrous-carbonylated-truncated-hemoglobins-from-mycobacterium-tuberculosis-and-campylobacter-jejuni-is-limited-by-carbon-monoxide-dissociation
#17
Paolo Ascenzi, Chiara Ciaccio, Tecla Gasperi, Alessandra Pesce, Lucia Caporaso, Massimo Coletta
Hydroxylamine (HA) is an oxidant of ferrous globins and its action has been reported to be inhibited by CO, even though this mechanism has not been clarified. Here, kinetics of the HA-mediated oxidation of ferrous carbonylated Mycobacterium tuberculosis truncated hemoglobin N and O (Mt-trHbN(II)-CO and Mt-trHbO(II)-CO, respectively) and Campylobacter jejuni truncated hemoglobin P (Cj-trHbP(II)-CO), at pH 7.2 and 20.0 °C, are reported. Mixing Mt-trHbN(II)-CO, Mt-trHbO(II)-CO, and Cj-trHbP(II)-CO solution with the HA solution brings about absorption spectral changes reflecting the disappearance of the ferrous carbonylated derivatives with the concomitant formation of the ferric species...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28643149/surface-modification-minimizes-the-toxicity-of-silver-nanoparticles-an-in-vitro-and-in-vivo-study
#18
Balaram Das, Satyajit Tripathy, Jaydeep Adhikary, Sourav Chattopadhyay, Debasis Mandal, Sandeep Kumar Dash, Sabyasachi Das, Aditi Dey, Sankar Kumar Dey, Debasis Das, Somenath Roy
Currently toxicological research in Silver nanoparticle is a leading issue in medical science. The surface chemistry and physical dimensions of silver nanoparticles (Ag-NPs) play an important role in toxicity. The aim of this present study was to evaluate the in vitro and in vivo toxicity of Ag-NPs as well as the alteration of toxicity profile due to surface functionalization (PEG and BSA) and the intracellular signaling pathways involved in nanoparticles mediated oxidative stress and apoptosis in vitro and in vivo system...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28639057/factors-controlling-the-reactivity-of-divalent-metal-ions-towards-pheophytin-a
#19
Ł Orzeł, J Waś, A Kania, A Susz, D Rutkowska-Zbik, J Staroń, M Witko, G Stochel, L Fiedor
In this study, we evaluate the factors which determine the reactivity of divalent metal ions in the spontaneous formation of metallochlorophylls, using experimental and computational approaches. Kinetic studies were carried out using pheophytin a in reactions with various divalent metal ions combined with non- or weakly-coordinative counter ions in a series of organic solvents. To obtain detailed insights into the solvent effect, the metalations with the whole set of cations were investigated in three solvents and with Zn(2+) in seven solvents...
August 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28620693/comparative-studies-of-reaction-of-cobalamin-ii-and-cobinamide-ii-with-sulfur-dioxide
#20
COMPARATIVE STUDY
Ilia A Dereven'kov, Pavel A Ivlev, Cristina Bischin, Denis S Salnikov, Radu Silaghi-Dumitrescu, Sergei V Makarov, Oscar I Koifman
The kinetics of reactions of cobalamin (II) and cobinamide (II) with sulfur dioxide was studied by UV-visible (UV-vis) spectroscopy. Reaction results in oxidation of Co(II) center and involves two aquated SO2 moieties. The final product is suggested to be complex Co(III)-S2O 4(•-) . The absence of corrin ring modifications during the reactions was proved.
August 2017: Journal of Biological Inorganic Chemistry: JBIC
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