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Allergology International: Official Journal of the Japanese Society of Allergology

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https://www.readbyqxmd.com/read/28784272/surveillance-of-the-use-of-adrenaline-auto-injectors-in-japanese-children
#1
Komei Ito, Manabu Ono, Naoyuki Kando, Teruaki Matsui, Tomoko Nakagawa, Shiro Sugiura, Motohiro Ebisawa
BACKGROUND: The appropriate usage of an adrenaline auto-injector (AAI, Epipen(®)) is a key aspect of patient and social education in the management of anaphylaxis. However, although AAIs are being prescribed increasingly frequently, there are few reports on their actual use. METHODS: The Anaphylaxis Working Group of the Japanese Society of Pediatric Allergy and Clinical Immunology requested that society members register cases in which AAIs were used. Two hundred and sixty-six cases were collected from March 2014 to March 2016...
August 4, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28778455/desensitization-to-a-whole-egg-by-rush-oral-immunotherapy-improves-the-quality-of-life-of-guardians-a-multicenter-randomized-parallel-group-delayed-start-design-study
#2
Naoka Itoh-Nagato, Yuzaburo Inoue, Mizuho Nagao, Takao Fujisawa, Naoki Shimojo, Tsutomu Iwata
BACKGROUND: Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL). METHODS: We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group...
August 1, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28764943/occupational-allergy-to-triticum-spelta-flour
#3
LETTER
Gemma Mencia, David El-Qutob, Fernando Pineda, Miriam Castillo
No abstract text is available yet for this article.
July 29, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28764942/bronchial-thermoplasty-for-severe-uncontrolled-asthma-in-japan
#4
LETTER
Motoyasu Iikura, Masayuki Hojo, Naoko Nagano, Keita Sakamoto, Konomi Kobayashi, Shota Yamamoto, Masao Hashimoto, Satoru Ishii, Shinyu Izumi, Haruhito Sugiyama
No abstract text is available yet for this article.
July 29, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28760534/an-analysis-of-factors-related-to-the-effect-of-sublingual-immunotherapy-on-japanese-cedar-pollen-induced-allergic-rhinitis
#5
Syuji Yonekura, Yoshitaka Okamoto, Daiju Sakurai, Kimihiro Okubo, Minoru Gotoh, Shinya Kaneko, Akiyoshi Konno
BACKGROUND: Sublingual immunotherapy (SLIT) can improve the symptoms of allergic rhinitis and modify its natural history; however, its efficacy varies among patients. This study aimed to determine which factors modify the effect of SLIT through post hoc analysis of a previous phase 3 trial of standardized Japanese cedar (JC) pollen extract (CEDARTOLEN(®)). METHODS: The study included 482 patients who had previously completed a phase 3 trial during two seasons. The SLIT and placebo groups each contained 241 subjects...
July 28, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28755856/th9-cells-induce-steroid-resistant-bronchial-hyperresponsiveness-in-mice
#6
Mayumi Saeki, Osamu Kaminuma, Tomoe Nishimura, Noriko Kitamura, Akio Mori, Takachika Hiroi
BACKGROUND: Reduced responsiveness to corticosteroid therapy is a major problem for patients with severe asthma. Although Th9 cells, along with Th2 cells, facilitate antigen-induced airway eosinophilia and bronchial hyperresponsiveness (BHR), the sensitivity of Th9 cell-mediated responses to steroid therapy remains unknown. In this study, we investigated the effect of dexamethasone (Dex) on antigen-induced airway inflammation in Th9 cell-transferred mice. METHODS: Ovalbumin (OVA)-specific Th2 and Th9 cells were polarized from the CD4(+) T cells of DO11...
July 26, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28754324/histopathological-and-clinical-evaluation-of-chronic-spontaneous-urticaria-patients-with-neutrophilic-and-non-neutrophilic-cutaneous-infiltrate
#7
Cíntia Freitas Martins, Karina Lopes Morais, Pamela Figueroa, Natasha Favoretto Dias, Neusa Sakai Valente, Celina Wakisaba Maruta, Paulo Ricardo Criado
BACKGROUND: Chronic urticaria has an expressive prevalence in general population, especially in adults, and is defined by the presence of intermittent hives for six weeks or longer. Our study aims to characterize the histological patterns of chronic spontaneous urticaria, based on the inflammatory cell infiltrate, and correlate them to laboratory exams. METHODS: It was performed a retrospective analysis of laboratory, histopathology and direct immunofluorescence data of 93 patients with chronic urticaria...
July 25, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28734740/immediate-type-allergic-reactions-to-local-anesthetics
#8
LETTER
Naomi Nakamura, Risa Tamagawa-Mineoka, Koji Masuda, Norito Katoh
No abstract text is available yet for this article.
July 19, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28734739/serum-levels-of-squamous-cell-carcinoma-antigens-1-and-2-reflect-disease-severity-and-clinical-type-of-atopic-dermatitis-in-adult-patients
#9
Tomoko Okawa, Yukie Yamaguchi, Kenzen Kou, Junya Ono, Yoshinori Azuma, Noriko Komitsu, Yusuke Inoue, Masumi Kohno, Setsuko Matsukura, Takeshi Kambara, Shoichiro Ohta, Kenji Izuhara, Michiko Aihara
BACKGROUND: Recent studies have indicated that serum levels of squamous cell carcinoma antigen (SCCA) 1 and 2 induced by type 2 cytokines such as IL-4 and IL-13, are increased in patients with atopic dermatitis (AD). However, no clinical studies have analyzed serum levels of SCCA2 in larger series of AD patients or their association with various clinical characteristics. This study was performed to clarify whether serum levels of SCCA2 are associated with disease severity and clinical phenotypes of adult AD patients...
July 19, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28716456/resveratrol-inhibits-ige-binding-and-down-regulates-intracellular-phosphorylation-of-syk-following-ige-aggregation-on-human-basophils
#10
LETTER
Sayaka Arakawa, Maho Suzukawa, Sayaka Igarashi, Hirotoshi Matsui, Masao Yamaguchi, Takahide Nagase, Ken Ohta
No abstract text is available yet for this article.
July 14, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28712741/epithelial-mesenchymal-transition-of-human-lung-adenocarcinoma-a549-cells-up-regulates-cytokine-production-upon-lps-stimulation
#11
LETTER
Takafumi Kato, Koichi Kobayashi, Maho Suzukawa, Minako Saito, Kenichi Okuda, Kazuya Koyama, Sayaka Igarashi, Sayaka Arakawa, Nobuharu Ohshima, Hirotoshi Matsui, Takahide Nagase, Ken Ohta
No abstract text is available yet for this article.
July 13, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28705588/elevated-uric-acid-and-adenosine-triphosphate-concentrations-in-bronchoalveolar-lavage-fluid-of-eosinophilic-pneumonia
#12
Takehito Kobayashi, Kazuyuki Nakagome, Toru Noguchi, Kiyoko Kobayashi, Yutaka Ueda, Tomoyuki Soma, Kenji Ikebuchi, Hidetomo Nakamoto, Makoto Nagata
BACKGROUND: Recent evidence has suggested that the innate immune response may play a role in the development of eosinophilic airway inflammation. We previously reported that uric acid (UA) and adenosine triphosphate (ATP), two important damage-associated molecular pattern molecules (DAMPs), activate eosinophil functions, suggesting that these molecules may be involved in the development of eosinophilic airway inflammation. The objective of this study was to measure the concentrations of DAMPs including UA and ATP in the bronchoalveolar lavage fluid (BALF) of patients with eosinophilic pneumonia (EP)...
July 10, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28693971/gut-microbiome-metabolome-and-allergic-diseases
#13
REVIEW
So-Ichiro Hirata, Jun Kunisawa
The number of patients with allergic and inflammatory disorders has been increasing during the past several decades. Accumulating evidence has refined our understanding of the relationship between allergic diseases and the gut microbiome. In addition, the gut microbiome is now known to produce both useful and harmful metabolites from dietary materials. These metabolites and bacterial components help to regulate host immune responses and potentially affect the development of allergic diseases. Here, we describe recent findings regarding the immunologic crosstalk between commensal bacteria and dietary components in the regulation of host immunity and the influence of this relationship on the development of allergic diseases...
July 8, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28690032/survey-on-the-proper-use-of-an-adrenaline-auto-injector-in-551-japanese-outdoor-workers-after-hymenoptera-stings
#14
LETTER
Hirokuni Hirata, Naruo Yoshida, Masamitsu Tatewaki, Sadaaki Shiromori, Kozo Sato, Tomoshige Wakayama, Shingo Tokita, Kumiya Sugiyama, Masafumi Arima, Kazuhiro Kurasawa, Takeshi Fukuda, Daisuke Shima, Yasutsugu Fukushima
No abstract text is available yet for this article.
July 7, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28684198/flow-cytometry-based-diagnosis-of-primary-immunodeficiency-diseases
#15
REVIEW
Hirokazu Kanegane, Akihiro Hoshino, Tsubasa Okano, Takahiro Yasumi, Taizo Wada, Hidetoshi Takada, Satoshi Okada, Motoi Yamashita, Tzu-Wen Yeh, Ryuta Nishikomori, Masatoshi Takagi, Kohsuke Imai, Hans D Ochs, Tomohiro Morio
Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs. Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and intranuclear proteins, biologic effects associated with specific immune defects, and certain functional immune characteristics, each being useful for the diagnosis and evaluation of PIDs...
July 3, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28676431/efficacy-of-oral-immunotherapy-with-a-rice-based-edible-vaccine-containing-hypoallergenic-japanese-cedar-pollen-allergens-for-treatment-of-established-allergic-conjunctivitis-in-mice
#16
Ken Fukuda, Waka Ishida, Yosuke Harada, Yuhya Wakasa, Hidenori Takagi, Fumio Takaiwa, Atsuki Fukushima
BACKGROUND: We have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice. METHODS: BALB/c mice were sensitized with two intraperitoneal injections of Japanese cedar pollen in alum, challenged with pollen in eyedrops, and then fed for 16 days with transgenic rice seeds expressing modified Japanese cedar pollen allergens Cry j 1 and Cry j 2 or with nontransgenic rice seeds as a control...
July 1, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28673440/a-lung-sound-analysis-in-a-child-thought-to-have-cough-variant-asthma-a-case-report
#17
LETTER
Eri Imai, Mayumi Enseki, Mariko Nukaga, Hideyuki Tabata, Kota Hirai, Masahiko Kato, Hiroyuki Mochizuki
No abstract text is available yet for this article.
June 30, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28669635/neuropsychiatry-phenotype-in-asthma-psychological-stress-induced-alterations-of-the-neuroendocrine-immune-system-in-allergic-airway-inflammation
#18
REVIEW
Isao Ohno
Since the recognition of asthma as a syndrome with complex pathophysiological signs and symptoms, recent research has sought to classify asthma phenotypes based on its clinical and molecular pathological features. Psychological stress was first recognized as a potential immune system modulator of asthma at the end of the 19th century. The activation of the central nervous system (CNS) upon exposure to psychological stress is integral for the initiation of signal transduction processes. The stress hormones, including glucocorticoids, epinephrine, and norepinephrine, which are secreted following CNS activation, are involved in the immunological alterations involved in psychological stress-induced asthma exacerbation...
June 29, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28655443/different-hypersensitivities-against-homologous-proteins-of-mgl_1304-in-patients-with-atopic-dermatitis
#19
Takuma Kohsaka, Takaaki Hiragun, Kaori Ishii, Makiko Hiragun, Akiko Kamegashira, Michihiro Hide
BACKGROUND: Atopic dermatitis (AD) is exacerbated by sweating, and the skin of most patients with AD are resided by Malassezia (M.) fungi. Recently, MGL_1304 produced by Malasseziaglobosa was identified as the major histamine releasing antigen in human sweat. METHODS: The full length cDNA of the counterpart of MGL_1304 in Malasseziarestricta (Mala r 8), was cloned by degenerate PCR and rapid identification of cDNA ends (RACE). Recombinant MGL_1304, and its counterparts, Mala s 8 (produced by Malasseziasympodialis) and Mala r 8 were prepared, and compared in their allergenicities by dot blot analysis and histamine release tests with sera and basophils of patients with AD...
June 24, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28648979/obesity-related-systemic-oxidative-stress-an-important-factor-of-poor-asthma-control
#20
LETTER
Masako To, Yuta Kono, Naoto Ogura, Shintaro Mikami, Natsue Honda, Akihiro Hitani, Ichino Kano, Kosuke Haruki, Yasuo To
No abstract text is available yet for this article.
June 23, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
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