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Allergology International: Official Journal of the Japanese Society of Allergology

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https://www.readbyqxmd.com/read/30648539/severe-asthma-in-children-evaluation-and-management
#1
REVIEW
Mehtap Haktanir Abul, Wanda Phipatanakul
Severe asthma in children is associated with significant morbidity. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life-threatening exacerbations, and impaired quality of life. It is important to differentiate between severe therapy resistant asthma and difficult-to-treat asthma due to comorbidities. The most common problems that need to be excluded before a diagnosis of severe asthma can be made are poor medication adherence, poor medication technique or incorrect diagnosis of asthma...
January 12, 2019: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30598404/thermography-high-sensitivity-and-specificity-diagnosing-contact-dermatitis-in-patch-testing
#2
Florian Anzengruber, Fayez Alotaibi, Lilian S Kaufmann, Adhideb Ghosh, Martin R Oswald, Julia-Tatjana Maul, Barbara Meier, Lars E French, Mathias Bonmarin, Alexander A Navarini
BACKGROUND: Patch testing of contact allergens to diagnose allergic contact dermatitis (ACD) is a traditional, useful tool. The most important decision is the distinction between allergic and irritant reactions, as this has direct implications on diagnosis and management. Our objective was to evaluate a new method of non-contact infrared reading of patch tests. Secondary objectives included a possible correlation between the intensity of the patch test reaction and temperature change...
December 28, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30573389/non-type-2-inflammation-in-severe-asthma-is-propelled-by-neutrophil-cytoplasts-and-maintained-by-defective-resolution
#3
REVIEW
Melody G Duvall, Nandini Krishnamoorthy, Bruce D Levy
Asthma is a highly prevalent heterogeneous inflammatory disorder of the airways. Not all patients respond to anti-inflammatory treatment with corticosteroids, leading to significant morbidity in severe asthma. Much attention has been paid to defining the cellular and molecular mechanisms of type 2 inflammation that are operative in asthma. Development of targeted therapies for pathologic type 2 inflammation is opening a new approach to asthma treatment; however, not all asthmatics have type 2 airway inflammation, especially those with severe corticosteroid-refractory asthma...
December 17, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30559050/intestinal-absorption-of-the-wheat-allergen-gliadin-in-rats
#4
Tomoharu Yokooji, Takahiro Fukushima, Koh Hamura, Naoki Ninomiya, Ryo Ohashi, Takanori Taogoshi, Hiroaki Matsuo
BACKGROUND: Aspirin enhances food allergy symptoms by increasing absorption of ingested allergens. The objective of this study is to elucidate the role of aspirin in facilitating intestinal absorption of the wheat allergen, gliadin, in rats. METHODS: Plasma concentrations of gliadin were determined after oral administration by gavage or administration into a closed intestinal loop in rats. We used an in situ intestinal re-circulating perfusion experiment to examine the effect of pepsin on aspirin-facilitated gliadin absorption...
December 14, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30527936/the-urticaria-control-test-and-urticaria-activity-score-correlate-with-quality-of-life-in-adult-japanese-patients-with-chronic-spontaneous-urticaria
#5
LETTER
Shoko Nakatani, Yoshiko Oda, Ken Washio, Atsushi Fukunaga, Chikako Nishigori
No abstract text is available yet for this article.
December 4, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30527935/bird-egg-syndrome-induced-by-%C3%AE-livetin-sensitization-in-a-budgerigar-keeper-successful-induction-of-tolerance-by-avoiding-exposure-to-avians
#6
LETTER
Naoko Inomata, Katsuyuki Kawano, Michiko Aihara
No abstract text is available yet for this article.
December 4, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30509734/obesity-and-severe-asthma
#7
REVIEW
Hiroki Tashiro, Stephanie A Shore
Obesity is an important global health issue for both children and adults. Obesity increases the prevalence and incidence of asthma and also increases the risk for severe asthma. Here we describe the features of severe asthma phenotypes for which obesity is a defining characteristic, including steroid resistance, airway inflammation, and co-morbidities. We also review current concepts regarding the mechanistic basis for the impact of obesity in severe asthma, including possible roles for vitamin D deficiency, systemic inflammation, and the microbiome...
November 30, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30473412/airway-innate-lymphoid-cells-in-the-induction-and-regulation-of-allergy
#8
REVIEW
Taylor A Doherty, David H Broide
The recent discovery of innate lymphoid cells has revolutionized our understanding of the pathogenesis of immune diseases including allergy and asthma. Innate lymphoid cells (ILCs) are a heterogeneous collection of lymphocytes that lack antigen-specificity (non-T, non-B cells) and potently produce characteristic cytokines of T cell subsets (Th1, Th2, Th17). ILCs are divided into group 1 (ILC1s), group 2 (ILC2s), or group 3 (ILC3s). Similar to Th2 cells, ILC2s produce IL-4, IL-5, and IL-13, among others, and are present in increased numbers in samples from patients with many allergic disorders including asthma and chronic rhinosinusitis (CRS)...
November 22, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30473411/obesity-but-not-metabolic-syndrome-as-a-risk-factor-for-late-onset-asthma-in-japanese-women
#9
Yasuhiro Tomita, Yuma Fukutomi, Mari Irie, Kazuhiro Azekawa, Hiroaki Hayashi, Yosuke Kamide, Kiyoshi Sekiya, Yoichi Nakamura, Chiharu Okada, Terufumi Shimoda, Yoshinori Hasegawa, Masami Taniguchi
BACKGROUND: Several cross-sectional studies have suggested an association between obesity and asthma. However, few studies have investigated this relationship longitudinally, especially in middle-aged subjects. Although metabolic syndrome is a well-known risk factor for many non-communicable diseases, its contribution to asthma remains controversial. METHODS: From 2008, specific health checkups for metabolic syndrome have been conducted throughout Japan. To seek relationships of obesity and metabolic syndrome with late-onset asthma in Japan, we analyzed data collected from health insurance claims and specific health checkups for metabolic syndrome at three large health insurance societies...
November 22, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30470479/critical-role-of-platelets-in-the-production-of-thymus-and-activation-regulated-chemokine-in-children-a-case-series-study
#10
LETTER
Yuka Okura, Yutaka Takahashi, Ichiro Kobayashi
No abstract text is available yet for this article.
November 20, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30424940/bidirectional-roles-of-il-22-in-the-pathogenesis-of-allergic-airway-inflammation
#11
REVIEW
Takashi Ito, Koichi Hirose, Hiroshi Nakajima
Asthma is the most prevalent allergic disease of the airway, which is characterized by eosinophilic inflammation, mucus hyperproduction, and airway hyper-responsiveness. Although these pathognomonic features are mainly mediated by antigen-specific Th2 cells and their cytokines, such as IL-4, IL-5, and IL-13, recent studies have revealed that other inflammatory cells, including Th17 cells and innate lymphoid cells (ILCs), also play a critical role in the pathogenesis of asthma. IL-22, one of the cytokines produced by Th17 cells and type 3 ILCs, has distinct functional properties, as IL-22 exclusively acts on non-hematopoietic cells including epithelial cells of mucosal surface and exhibits a broad range of action in regeneration and host protection...
November 10, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30420208/periostin-deletion-suppresses-late-phase-response-in-mouse-experimental-allergic-conjunctivitis
#12
Yosuke Asada, Mikiko Okano, Waka Ishida, Satoshi Iwamoto, Ken Fukuda, Toshiaki Hirakata, Norihiro Tada, Atsuki Fukushima, Nobuyuki Ebihara, Akira Kudo, Akira Matsuda
BACKGROUND: To investigate the potential roles of periostin (POSTN), an extracellular matrix preferentially expressed in Th2-skewed conditions in the pathophysiology of allergic conjunctivitis. METHODS: The roles of POSTN in ragweed-induced experimental allergic conjunctivitis (RW-EAC) were evaluated using both POSTN-knockout (KO) and congenic BALB/c wild-type mice. Histological analysis was carried out to enumerate eosinophils/basophils in the conjunctival tissue...
November 9, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30391169/efficacy-and-safety-of-rupatadine-in-japanese-patients-with-seasonal-allergic-rhinitis-a-double-blind-randomized-multicenter-placebo-controlled-clinical-trial
#13
Kimihiro Okubo, Takamasa Suzuki, Ayaka Tanaka, Hiroshi Aoki
BACKGROUND: Rupatadine is a novel non-sedating second-generation H1 -antihistamine with antiplatelet-activating factor activity, first marketed in Spain in 2003. It is used for treating allergic rhinitis in more than 80 countries. This study investigated its efficacy and safety in Japanese patients with seasonal allergic rhinitis (SAR). METHODS: This was a randomized, placebo-controlled, double-blind study conducted at 4 medical institutions in Japan (JapicCTI-152785)...
October 31, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30591151/new-trends-in-mucosal-immunology-and-allergy
#14
EDITORIAL
Hiroshi Kiyono, Kenji Izuhara
No abstract text is available yet for this article.
January 2019: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30029967/efficacy-and-safety-of-rupatadine-in-japanese-adult-and-adolescent-patients-with-chronic-spontaneous-urticaria-a-double-blind-randomized-multicenter-placebo-controlled-clinical-trial
#15
Michihiro Hide, Takamasa Suzuki, Ayaka Tanaka, Hiroshi Aoki
BACKGROUND: Rupatadine, a novel nonsedating second-generation H1-antihistamine with antiplatelet-activating factor activity, has been used in the treatment of allergic rhinitis and urticaria in European countries since 2003. However, its efficacy and safety in Japanese patients with chronic spontaneous urticaria (CSU) are unknown. METHODS: We conducted a prospective, multicenter, randomized, placebo-controlled, double-blind study in adolescent and adult CSU outpatients aged 12 to < 65 years (JAPIC-CTI No...
January 2019: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30366757/a-comprehensive-understanding-of-the-gut-mucosal-immune-system-in-allergic-inflammation
#16
REVIEW
Daisuke Tokuhara, Yosuke Kurashima, Mariko Kamioka, Toshinori Nakayama, Peter Ernst, Hiroshi Kiyono
Despite its direct exposure to huge amounts of microorganisms and foreign and dietary antigens, the gut mucosa maintains intestinal homeostasis by utilizing the mucosal immune system. The gut mucosal immune system protects the host from the invasion of infectious pathogens and eliminates harmful non-self antigens, but it allows the cohabitation of commensal bacteria in the gut and the entry of dietary non-self antigens into the body via the mucosal surface. These physiological and immunological activities are regulated by the ingenious gut mucosal immune network, comprising such features as gut-associated lymphoid tissue, mucosal immune cells, cytokines, chemokines, antimicrobial peptides, secretory IgA, and commensal bacteria...
October 23, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30355455/identification-of-biomarkers-for-predicting-the-response-to-cyclosporine-a-therapy-in-patients-with-chronic-spontaneous-urticaria
#17
LETTER
Takahiro Endo, Shota Toyoshima, Kazuko Kanegae, Satoshi Izaki, Nobuyuki Nishimori, Mana Ito, Kazuko Sugai, Koremasa Hayama, Tadashi Terui, Yoshimichi Okayama
No abstract text is available yet for this article.
October 22, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30348485/reduced-nasal-nitric-oxide-levels-in-patients-with-eosinophilic-chronic-rhinosinusitis
#18
Kanako Yoshida, Tetsuji Takabayashi, Yoshimasa Imoto, Masafumi Sakashita, Norihiko Narita, Shigeharu Fujieda
BACKGROUND: In Eosinophilic chronic rhinosinusitis (ECRS), it is difficult to estimate the refractoriness and recurrence risk for each patient. Fraction of exhaled nitric oxide (FeNO) is known as a biomarker of eosinophilic inflammation in lower airway. It has been reported that nasal NO has some crucial functions in the upper and lower airways. However, in upper airway, paranasal sinuses, the usefulness of NO measurement remains controversial. The purpose of this study is to identify the usefulness of nasal NO measurement in ECRS and the involvement of nasal NO in the pathogenesis of ECRS...
October 19, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30342889/sema4a-promotes-eosinophil-survival-and-contributes-to-eosinophil-mediated-allergic-diseases
#19
LETTER
Yohei Maeda, Takeshi Tsuda, Yoshito Takeda, Shohei Koyama, Yoshitomo Hayama, Satoshi Nojima, Tetsuya Kimura, Daisuke Ito, Hyota Takamatsu, Sujin Kang, Masayuki Nishide, Keiko Morimoto, Takashi Hosokawa, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Kazuya Takeda, Masaki Hayama, Sho Obata, Hitoshi Akazawa, Takashi Shikina, Hidenori Inohara, Atsushi Kumanogoh
No abstract text is available yet for this article.
October 17, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/30342888/efficacy-of-a-short-pretreatment-with-omalizumab-in-children-with-anaphylaxis-to-hymenoptera-venom-immunotherapy-a-report-of-three-cases
#20
LETTER
Catherine Droitcourt, Claude Ponvert, Alain Dupuy, Pierre Scheinmann, Rola Abou-Taam, Jacques de Blic, Guillaume Lezmi
No abstract text is available yet for this article.
October 17, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
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