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Allergology International: Official Journal of the Japanese Society of Allergology

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https://www.readbyqxmd.com/read/29128192/efficacy-and-safety-of-benralizumab-in-japanese-patients-with-severe-uncontrolled-eosinophilic-asthma
#1
Ken Ohta, Mitsuru Adachi, Yuji Tohda, Tadashi Kamei, Motokazu Kato, J Mark Fitzgerald, Masayuki Takanuma, Tadahiro Kakuno, Nobuyuki Imai, Yanping Wu, Magnus Aurivillius, Mitchell Goldman
BACKGROUND: In the Phase III CALIMA trial, benralizumab significantly reduced asthma exacerbations, increased lung function, and alleviated symptoms for patients with severe, uncontrolled eosinophilic asthma. The aim of this subgroup analysis was to evaluate the efficacy and safety of benralizumab for Japanese patients in the CALIMA trial. METHODS: CALIMA was a randomised, controlled trial of 1306 patients (aged 12-75 years; registered at ClinicalTrials.gov: NCT01914757) with severe asthma uncontrolled by medium- to high-dosage inhaled corticosteroids and long-acting β2-agonists (ICS/LABA)...
November 8, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29122495/up-regulation-of-serum-periostin-and-squamous-cell-carcinoma-antigen-levels-in-infants-with-acute-bronchitis-due-to-respiratory-syncytial-virus
#2
Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Noriko Ogasawara, Keisuke Yamamoto, Norikazu Shimizu, Hiroyuki Tsutsumi, Kenji Izuhara, Toshio Katsunuma
BACKGROUND: Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. METHODS: Infants younger than 36 months were enrolled and classified into three groups...
November 6, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29103905/how-important-is-allergic-sensitization-as-a-cause-of-atopic-asthma
#3
LETTER
Jun Kanazawa, Hironori Masuko, Hideyasu Yamada, Yohei Yatagai, Tohru Sakamoto, Haruna Kitazawa, Hiroaki Iijima, Takashi Naito, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
No abstract text is available yet for this article.
November 2, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29102514/efficacy-and-safety-of-omalizumab-for-the-treatment-of-refractory-chronic-spontaneous-urticaria-in-japanese-patients-subgroup-analysis-of-the-phase-3-polaris-study
#4
Michihiro Hide, Atsuyuki Igarashi, Akiko Yagami, Yuko Chinuki, Naoko Inomata, Atsushi Fukunaga, Guenther Kaiser, Junyi Wang, Soichiro Matsushima, Steven Greenberg, Sam Khalil
BACKGROUND: Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H1 antihistamines (H1AH) in the POLARIS study (NCT02329223), a randomized, double-blind, placebo-controlled trial in East Asian patients. However, data in Japanese patients, who have specific baseline characteristics (e.g., low angioedema incidence, different background medications) that may impact clinical outcomes, are lacking...
November 1, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29092781/successful-treatment-of-refractory-alopecia-universalis-by-persuading-a-patient-not-to-sleep-with-her-dog
#5
LETTER
Takahiro Arita, Tomoko Nomiyama, Jun Asai, Norito Katoh
No abstract text is available yet for this article.
October 30, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29066290/phenotype-classification-using-the-combination-of-lung-sound-analysis-and-fractional-exhaled-nitric-oxide-for-evaluating-asthma-treatment
#6
Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Sadahiro Asai
BACKGROUND: We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200-400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment. METHODS: A total of 233 patients with bronchial asthma were included...
October 21, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28993062/chronic-spontaneous-urticaria-and-the-extrinsic-coagulation-system
#7
REVIEW
Yuhki Yanase, Shunsuke Takahagi, Michihiro Hide
Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway...
October 6, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28965921/therapeutic-approaches-of-asthma-and-copd-overlap
#8
REVIEW
Mitsuko Kondo, Jun Tamaoki
Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and high economic burden. However, no large-scaled therapeutic trials of ACO have been conducted. At present, ACO is treated according to asthma/COPD guidelines. The goals of ACO treatment are to relieve symptoms and improve QOL and lung functions. Treatment must also prevent disease progression, airway remodeling, exacerbation, complications, and comorbidities...
September 28, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28964642/a-case-of-clinically-amyopathic-dermatomyositis-that-developed-during-anti-tnf-%C3%AE-therapy-for-rheumatoid-arthritis
#9
LETTER
Miki Takata, Akira Yamasaki, Nanako Yamada, Hiroshi Hagino, Yoshihiro Funaki, Tomoya Harada, Ryota Okazaki, Yasuyuki Hasegawa, Takehito Fukushima, Masato Morita, Yuriko Sueda, Akihiro Yamamoto, Eiji Shimizu
No abstract text is available yet for this article.
September 27, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28941636/role-of-airway-epithelial-barrier-dysfunction-in-pathogenesis-of-asthma
#10
REVIEW
Yasuhiro Gon, Shu Hashimoto
Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation. Repeated injury, repair, and regeneration of the airway epithelium following exposure to environmental factors and inflammation results in histological changes and functional abnormalities in the airway mucosal epithelium; such changes are believed to have a significant association with the pathophysiology of asthma...
September 20, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28935120/vitamin-d-deficiency-exacerbates-sensitization-and-allergic-diarrhea-in-a-murine-food-allergy-model
#11
LETTER
Teruaki Matsui, Hirotaka Yamashita, Ken-Ichi Saneyasu, Hiroyuki Tanaka, Komei Ito, Naoki Inagaki
No abstract text is available yet for this article.
September 18, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28927962/long-term-course-of-serum-total-and-free-ige-levels-in-severe-asthma-patients-treated-with-omalizumab
#12
LETTER
Yasuhiro Gon, Reiko Ito, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Yuko Iida, Mari Hikichi, Sotaro Shikano, Shu Hashimoto
No abstract text is available yet for this article.
September 16, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28919488/mast-cells-derived-from-human-induced-pluripotent-stem-cells-are-useful-for-allergen-tests
#13
Akira Igarashi, Yasuhiro Ebihara, Tomoaki Kumagai, Hiroyuki Hirai, Kinya Nagata, Kohichiro Tsuji
BACKGROUND: Several methods have been developed to detect allergen-specific IgE in sera. The passive IgE sensitization assay using human IgE receptor-expressing rat cell line RBL-2H3 is a powerful tool to detect biologically active allergen-specific IgE in serum samples. However, one disadvantage is that RBL-2H3 cells are vulnerable to high concentrations of human sera. Only a few human cultured cell lines are easily applicable to the passive IgE sensitization assay. However, the use of human induced pluripotent stem cells (iPSCs) to generate human mast cells (MCs) has not yet been reported...
September 14, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28886913/mucus-plugging-in-allergic-bronchopulmonary-aspergillosis-implication-of-the-eosinophil-dna-traps
#14
LETTER
Ayumi Omokawa, Shigeharu Ueki, Yuta Kikuchi, Masahide Takeda, Mariko Asano, Kazuhiro Sato, Masaaki Sano, Hiroshi Ito, Makoto Hirokawa
No abstract text is available yet for this article.
September 5, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28882557/exposure-amount-and-timing-of-solar-irradiation-during-pregnancy-and-the-risk-of-sensitization-in-children
#15
Hyun Yong Koh, Eunhae Cho, So-Yeon Lee, Woo Kyung Kim, Yong Mean Park, Jihyun Kim, Kangmo Ahn, Seung Won Lee, Mi Ae Kim, Myung-Il Hahm, Yoomi Chae, Kee-Jae Lee, Ho-Jang Kwon, Man Yong Han
BACKGROUND: Solar irradiation affects sensitization to aeroallergens and the prevalence of allergic diseases. Little is known, however, about how the time and amount of solar irradiation during pregnancy affects such risks in children. We aimed to find out how solar irradiation during pregnancy affects sensitization to aero-allergens and the prevalence of allergic diseases in children. METHODS: This population-based cross-sectional study involved 7301 aged 6 years and aged 12 years children...
September 4, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28874315/hand-eczema-as-a-risk-factor-for-food-allergy-among-occupational-kitchen-workers
#16
Takafumi Minami, Yuma Fukutomi, Kiyoshi Sekiya, Akira Akasawa, Masami Taniguchi
BACKGROUND: An increasing number of studies in children is highlighting the importance of transdermal routes of exposure to food allergens through damaged skin in the pathogenesis of food allergies. However, data on this in adults are limited. A few case-series studies has documented development of food allergy among kitchen workers with hand eczema after direct contact exposure to foods. METHODS: To explore the significance of hand eczema as a risk factor for food allergies in adults at the epidemiological level, we performed a cross-sectional web-based questionnaire survey on kitchen workers whose exposures were classed as occupational (cooks and food handlers, n = 1592) or non-occupational (housewives, n = 1915)...
September 2, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28867215/development-of-a-questionnaire-to-evaluate-asthma-control-in-japanese-asthma-patients
#17
Yuji Tohda, Soichiro Hozawa, Hiroshi Tanaka
BACKGROUND: The asthma control questionnaires used in Japan are Japanese translations of those developed outside Japan, and have some limitations; a questionnaire designed to optimally evaluate asthma control levels for Japanese may be necessary. The present study was conducted to validate the Japan Asthma Control Survey (JACS) questionnaire in Japanese asthma patients. METHODS: A total of 226 adult patients with mild to severe persistent asthma were enrolled and responded to the JACS questionnaire, asthma control questionnaire (ACQ), and Mini asthma quality of life questionnaire (Mini AQLQ) at Weeks 0 and 4...
August 31, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28843441/urticaria-by-thiamine-vitamin-b1
#18
LETTER
Ana Rodríguez-Fernández, Marcos Sánchez-Domínguez, Blanca Noguerado-Mellado, Patricia Rojas-Pérez-Ezquerra
No abstract text is available yet for this article.
August 23, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28964405/old-friends-microbes-and-allergic-diseases
#19
EDITORIAL
Naoki Shimojo, Kenji Izuhara
No abstract text is available yet for this article.
October 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28882556/role-of-the-microbiota-in-skin-immunity-and-atopic-dermatitis
#20
REVIEW
Yuriko Yamazaki, Yuumi Nakamura, Gabriel Núñez
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15-20% of children and 2-5% of adults in industrialized countries. The pathogen Staphylococcus aureus selectively colonizes the lesional skin of AD patients while this bacterium is absent in the skin of the majority of healthy individuals. However, the role of S. aureus in the pathogenesis of AD remains poorly understood. In addition to S. aureus, recent studies show a contribution of the skin microbiota to the regulation of immune responses in the skin as well as to the development of inflammatory skin disease...
October 2017: Allergology International: Official Journal of the Japanese Society of Allergology
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