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International Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/29992389/definitive-chemoradiotherapy-for-anal-canal-cancer-single-center-experience
#1
Izumi Tachibana, Yasumasa Nishimura, Masahiro Inada, Kohei Fukuda, Kazuki Ishikawa, Tatsuyuki Nishikawa, Masaki Yokokawa, Kiyoshi Nakamatsu, Shuichi Kanamori, Jin-Ichi Hida
BACKGROUND: Chemoradiotherapy (CRT) is a standard treatment for anal canal cancer although many patients with anal canal cancer undergo surgery in Japan. The efficacy of CRT for anal canal cancer was evaluated retrospectively. METHODS: Medical charts of 13 patients with anal canal cancer treated by definitive CRT from October 2004 to May 2016 were reviewed. Twelve patients had squamous cell carcinoma and one had adeno-squamous carcinoma. PET/CT simulation was performed in nine patients...
July 10, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29974295/comparison-of-the-university-of-pittsburgh-staging-system-and-the-eighth-edition-of-the-american-joint-committee-on-cancer-tnm-classification-for-the-prognostic-evaluation-of-external-auditory-canal-cancer
#2
Shinya Morita, Takatsugu Mizumachi, Yuji Nakamaru, Tomohiro Sakashita, Satoshi Kano, Kimiko Hoshino, Atsushi Fukuda, Keishi Fujiwara, Akihiro Homma
BACKGROUND: The purpose was to compare survival differences between patients with external auditory canal (EAC) cancer treated according to the University of Pittsburgh modified TNM staging system and those treated in accordance with the 8th edition of the American Joint Committee on Cancer (AJCC) staging manual on the TNM staging system for cutaneous cancers of the head and neck. METHODS: We performed a retrospective, single-institution review of 60 patients with EAC cancer treated with curative intent between September 2002 and March 2018...
July 5, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29974294/cardiac-output-response-to-exercise-in-patients-before-allogenic-hematopoietic-stem-cell-transplantation
#3
Shinya Yoshida, Fujiko Someya, Tetsutaro Yahata
INTRODUCTION: High-dose chemotherapy for remission induction can induce cardiac toxicity prior to hematopoietic stem cell transplantation (HSCT). However, the details of cardiac function in patients undergoing HSCT are unclear, particularly during exercise. The aim of present study was to evaluate cardiac output responses to exercise in patients after high-dose chemotherapy before HSCT compared with in age-matched healthy controls. METHODS: Twenty-nine patients before HSCT (age 44...
July 5, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29971622/clinical-evaluation-of-two-consecutive-urovysion-fluorescence-in-situ-hybridization-tests-to-detect-intravesical-recurrence-of-bladder-cancer-a-prospective-blinded-comparative-study-in-japan
#4
Takahiro Kojima, Hiroyuki Nishiyama, Seiichiro Ozono, Shiro Hinotsu, Naoto Keino, Akito Yamaguchi, Hideki Sakai, Yutaka Enomoto, Shigeo Horie, Kiyohide Fujimoto, Hideyasu Matsuyama, Takehiko Okamura, Yusuke Kanimoto, Mototsugu Oya, Norio Nonomura, Seiji Naito, Hideyuki Akaza
BACKGROUND: We evaluated the use of UroVysion fluorescence in situ hybridization tests to detect the intravesical recurrence of bladder cancer during follow-up after a transurethral resection of bladder tumor (TURBT). METHODS: In this prospective, blinded, comparative study, 486 patients treated by TURBT within the prior 2 years were registered at 12 centers. Urine cytology and UroVysion tests were performed once or twice at a central testing laboratory. For the patients with no suspicious findings of bladder cancer in the first analysis, the same examination set was repeated 3 months later as the second analysis...
July 3, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29971621/present-clinical-practices-of-stereotactic-irradiation-for-metastatic-brain-tumors-in-japan-results-of-questionnaire-survey-of-the-japanese-radiation-oncology-study-group-jrosg-working-subgroup-for-neurological-tumors
#5
Ken Harada, Hiroshi Igaki, Eisuke Abe, Takuro Ariga, Nobuyuki Hayashi, Ayae Kanemoto, Takafumi Komiyama, Yasuo Matsumoto, Toshimichi Nakano, Rikiya Onimaru, Hirotake Saito, Minako Sumi, Masao Tago, Kensuke Tanaka, Katsuya Maebayashi, Hidefumi Aoyama
BACKGROUND: To determine the current practice of stereotactic irradiation (STI) for brain metastases in Japan by a questionnaire survey. METHODS: A questionnaire was distributed to 313 institutions performing STI with one of the following machines: Gamma Knife (GK), CyberKnife (CK), Novalis (Nov), or other linear accelerator (LINAC)-based systems (OLS). The participation was voluntary. RESULTS: There were 163 responding institutions. The total number of STI treatments between April 2013 and March 2014 was 10,684...
July 3, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29968168/clinical-outcomes-of-brain-metastases-from-hepatocellular-carcinoma-a-multicenter-retrospective-study-and-a-literature-review
#6
Takeshi Okuda, Nakamasa Hayashi, Masamichi Takahashi, Takeo Uzuka, Yoshiko Okita, Ryohei Otani, Toshiyuki Fujinaka, Mitsugu Fujita, Amami Kato, Yoshitaka Narita, Yoko Nakasu
INTRODUCTION: The introduction of systemic chemotherapy for advanced hepatocellular carcinoma in recent years has led to the prediction that cases of brain metastases from hepatocellular carcinoma will increase. However, because brain metastases from hepatocellular carcinoma are relatively rare, the characteristics of this pathology are poorly understood. METHODS: We carried out a multicenter retrospective study to verify the characteristics of brain metastases from hepatocellular carcinoma in Japan...
July 2, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29959563/radiotherapy-combined-with-zoledronate-can-reduce-skeletal-related-events-in-renal-cell-carcinoma-patients-with-bone-metastasis
#7
Seiichi Hosaka, Hirohisa Katagiri, Masashi Niwakawa, Hideyuki Harada, Junji Wasa, Hideki Murata, Mitsuru Takahashi
BACKGROUND: Skeletal-related events (SRE) are common in patients with renal cell carcinoma (RCC) that includes bone metastasis. The purpose of this study was to clarify the effectiveness of zoledronate with and without sunitinib, combined with radiotherapy, for the treatment of bone metastasis from RCC. METHODS: We retrospectively analyzed 62 RCC patients with bone metastasis, who had been treated with radiotherapy at our institution. We divided the study cohort into two groups: patients treated with radiotherapy alone (RT; n = 27) and those treated with radiotherapy combined with zoledronate (RT + Z; n = 35)...
June 29, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29934842/nationwide-japanese-prostate-cancer-outcome-study-of-permanent-iodine-125-seed-implantation-j-pops-first-analysis-on-survival
#8
Kazuto Ito, Shiro Saito, Atsunori Yorozu, Shinsuke Kojima, Takashi Kikuchi, Satoshi Higashide, Manabu Aoki, Hirofumi Koga, Takefumi Satoh, Toshio Ohashi, Katsumasa Nakamura, Norihisa Katayama, Nobumichi Tanaka, Masahiro Nakano, Naoyuki Shigematsu, Takushi Dokiya, Masanori Fukushima
BACKGROUND: Investigating oncological outcomes in patients registered in the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS) in terms of biochemical relapse-free survival (bRFS) by the Phoenix and the newly developed J-POPS definitions, exploration of predictive factors for bRFS, and preliminary verification of pitfalls of prostate-specific antigen (PSA) failure definitions. METHODS: Between July 2005 and June 2007, 2316 clinically localized patients underwent permanent seed implantation...
June 22, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29931597/phase-ii-study-of-s-1-plus-oxaliplatin-130-mg-m-2-in-japanese-patients-with-advanced-gastric-cancer
#9
Yosuke Kito, Nozomu Machida, Sadayuki Kawai, Satoshi Hamauchi, Takahiro Tsushima, Akiko Todaka, Tomoya Yokota, Kentaro Yamazaki, Akira Fukutomi, Yusuke Onozawa, Kunihiro Tsuji, Hisashi Doyama, Yutaka Haraguchi, Koji Nakashima, Kenji Kunieda, Keisei Taku, Keita Mori, Hirofumi Yasui
PURPOSE: Although oxaliplatin 130 mg/m2 every 3 weeks was approved for advanced gastric cancer in Japan, data regarding S-1 plus oxaliplatin 130 mg/m2 (SOX130) are limited in Japanese patients with advanced gastric cancer. We investigated the feasibility and safety of SOX130 in Japanese patients with advanced gastric cancer. METHODS: Patients with unresectable or recurrent gastric adenocarcinoma, no previous chemotherapy, and Eastern Cooperative Oncology Group Performance Status of 0-1 were treated with SOX130...
June 21, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29948240/colorectal-obstruction-is-a-potential-prognostic-factor-for-stage-ii-colorectal-cancer
#10
Yusuke Okuda, Takaya Shimura, Tomonori Yamada, Yoshikazu Hirata, Ryuzo Yamaguchi, Eiji Sakamoto, Hiromi Kataoka
BACKGROUND: Obstructive colorectal cancer (CRC) is an emergency situation with high morbidity and mortality, but long-term outcomes of stage II/III obstructive CRC remain unclear. The aim of this study was to evaluate prognostic factors, including colorectal obstruction. METHODS: Data were retrospectively reviewed from consecutive patients with stage II/III CRC who underwent curative surgery between January 2007 and December 2011 at two Japanese institutions. We analyzed overall survival (OS) and relapse-free survival (RFS), according to various prognostic factors including colorectal obstruction...
June 15, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29948239/changes-in-programmed-death-ligand-1-expression-in-non-small-cell-lung-cancer-patients-who-received-anticancer-treatments
#11
Shota Omori, Hirotsugu Kenmotsu, Masato Abe, Reiko Watanabe, Takashi Sugino, Haruki Kobayashi, Kazuhisa Nakashima, Kazushige Wakuda, Akira Ono, Tetsuhiko Taira, Tateaki Naito, Haruyasu Murakami, Yasuhisa Ohde, Masahiro Endo, Yasuto Akiyama, Takashi Nakajima, Toshiaki Takahashi
BACKGROUND: The expression of programmed death ligand 1 (PD-L1) is considered a predictive biomarker of anti-programmed death 1 (PD-1)/PD-L1 cancer therapies. However, changes in PD-L1 expression of tumor cells during clinical courses have not been fully evaluated. We evaluated changes in PD-L1 expression for non-small cell lung cancer (NSCLC) patients who received anticancer treatments during clinical courses. METHODS: In 76 NSCLC patients, PD-L1 expression was evaluated before and after anticancer treatment by immunohistochemical (IHC) analysis using an anti-PD-L1 antibody...
June 15, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29948238/primary-prophylactic-granulocyte-colony-stimulating-factor-according-to-asco-guidelines-has-no-preventive-effect-on-febrile-neutropenia-in-patients-treated-with-docetaxel-cisplatin-and-5-fluorouracil-chemotherapy
#12
Masahiro Kawahira, Tomoya Yokota, Satoshi Hamauchi, Sadayuki Kawai, Yukio Yoshida, Yusuke Onozawa, Takahiro Tsushima, Akiko Todaka, Nozomu Machida, Kentaro Yamazaki, Akira Fukutomi, Hirofumi Yasui
BACKGROUND: The efficacy of primary prophylactic granulocyte colony-stimulating factor (G-CSF) in preventing febrile neutropenia (FN) in patients treated with docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy remains controversial. We compared the incidence of FN in patients treated with and without primary prophylactic G-CSF. METHODS: We performed a retrospective analysis of 142 patients with locally advanced head and neck or esophageal cancer treated with TPF between January 2009 and March 2017...
June 15, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29876691/observational-study-of-chemotherapy-induced-clostridium-difficile-infection-in-patients-with-lung-cancer
#13
Yukihiro Toi, Shunichi Sugawara, Takao Kobayashi, Keisuke Terayama, Yoshihiro Honda
BACKGROUND: Diarrhea post-antibiotic use is primarily attributed to Clostridium difficile infection (CDI)-induced mucosal lesions, and evidence of CDI in patients undergoing chemotherapy without prior antibiotic treatment is also increasing. However, few studies have investigated the relationship between chemotherapy use and diarrhea. This study aimed to determine whether the incidence of CDI increased in patients with lung cancer undergoing chemotherapy even without prior antibiotic treatment...
June 6, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29869758/secondary-cancer-after-a-childhood-cancer-diagnosis-viewpoints-considering-primary-cancer
#14
Yasushi Ishida, Miho Maeda, Souichi Adachi, Hiroko Inada, Hiroshi Kawaguchi, Hiroki Hori, Atsushi Ogawa, Kazuko Kudo, Chikako Kiyotani, Hiroyuki Shichino, Takeshi Rikiishi, Ryoji Kobayashi, Maho Sato, Jun Okamura, Hiroaki Goto, Atsushi Manabe, Shinji Yoshinaga, Dongmei Qiu, Junichiro Fujimoto, Tatsuo Kuroda
BACKGROUNDS: Multidisciplinary therapy has increased the risk of subsequent late effects, but detailed analyses on secondary cancers in childhood cancer survivors (CCSs) are limited in Asian countries. METHODS: This was a retrospective cohort study comprising 10,069 CCSs who were diagnosed between 1980 and 2009 across 15 Japanese hospitals. We conducted secondary analyses to estimate the incidence of secondary cancer according to each primary malignancy and to elucidate the association between primary and secondary cancers...
June 5, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29869757/early-recurrence-after-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec
#15
Grace Hwei Ching Tan, Claramae Shulyn Chia, Sze Huey Tan, Khee Chee Soo, Melissa Ching Ching Teo
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are used in the management of selected peritoneal malignancies. While most patients achieve long-term disease-free survival, there remains a group with early recurrence (ER). We aim to investigate the clinical factors associated with ER. METHODS: A retrospective review of a prospectively maintained database of CRS-HIPEC patients treated between April 2001 and Feb 2016 was performed...
June 5, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29860539/relationships-between-sunitinib-plasma-concentration-and-clinical-outcomes-in-japanese-patients-with-metastatic-renal-cell-carcinoma
#16
Shinya Takasaki, Yoshihide Kawasaki, Masafumi Kikuchi, Masaki Tanaka, Masato Suzuka, Aoi Noda, Yuji Sato, Shinichi Yamashita, Koji Mitsuzuka, Hideo Saito, Akihiro Ito, Hiroaki Yamaguchi, Yoichi Arai, Nariyasu Mano
BACKGROUND: The aim was to investigate the relationships between total sunitinib plasma concentrations (sunitinib plus its active metabolite; N-desethyl sunitinib) and clinical outcomes in Japanese patients with metastatic renal cell carcinoma (mRCC). METHODS: Twenty patients with mRCC were enrolled following treatment with sunitinib. To assess safety, the total sunitinib concentration range up to discontinuation of treatment and dosage reduction associated with adverse events within 6 weeks from initiating administration were analyzed...
June 2, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29845477/plasma-concentrations-of-dasatinib-have-a-clinical-impact-on-the-frequency-of-dasatinib-dose-reduction-and-interruption-in-chronic-myeloid-leukemia-an-analysis-of-the-daria-01-study
#17
Shuichi Mizuta, Masashi Sawa, Hisashi Tsurumi, Kana Matsumoto, Kotaro Miyao, Takeshi Hara, Takeshi Takahashi, Reona Sakemura, Hiroshi Kojima, Akio Kohno, Mari S Oba, Satoshi Morita, Junichi Sakamoto, Nobuhiko Emi
BACKGROUND: Dasatinib has shown promising anti-leukemic activity against chronic myeloid leukemia (CML). However, patients receiving dasatinib frequently require dose reductions and treatment interruptions (treatment alteration). METHODS: We prospectively analyzed the frequency and significance of treatment alteration during dasatinib therapy in patients with CML. In all patients, trough plasma concentrations of dasatinib (Cmin ) at steady state were assessed on day 28 of therapy...
May 29, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29804156/development-and-external-validation-of-a-nomogram-to-predict-high-grade-papillary-bladder-cancer-before-first-time-transurethral-resection-of-the-bladder-tumor
#18
Ken Wakai, Takanobu Utsumi, Kei Yoneda, Ryo Oka, Takumi Endo, Masashi Yano, Masaaki Fujimura, Naoto Kamiya, Nobuyuki Sekita, Kazuo Mikami, Isamu Sugano, Nobuyuki Hiruta, Hiroyoshi Suzuki
BACKGROUND: The aim of this study was to identify the clinical predictors related to the risk of high-grade papillary bladder cancer before first-time transurethral resection of a bladder tumor (TUR-Bt), and to develop and validate a nomogram predicting the risk of high-grade papillary bladder cancer. METHODS: A retrospective clinical study of consecutive patients who underwent first-time TUR-Bt for papillary bladder cancer was performed. Medical records were reviewed uniformly, and the following data were collected: age, sex, episodes of urinary symptoms, tumor size, number of tumors, location of the largest tumor (lateral walls, base, posterior wall, dome, and anterior wall), tumor appearance (papillary or non-papillary, pedunculated or sessile), and urinary cytology...
May 26, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29796740/treatment-outcomes-of-hypofractionated-radiotherapy-combined-with-temozolomide-followed-by-bevacizumab-salvage-therapy-in-glioblastoma-patients-aged-75-years
#19
Ken-Ichiro Matsuda, Kaori Sakurada, Kenji Nemoto, Takamasa Kayama, Yukihiko Sonoda
BACKGROUND: The optimal treatment for elderly patients with glioblastoma has not been established. METHODS: We retrospectively analyzed the safety and efficacy of hypofractionated radiotherapy (45 Gy/15 fr) combined with temozolomide (TMZ) followed by bevacizumab (BEV) salvage treatment in 18 glioblastoma patients aged > 75 years. RESULTS: All of the patients received safe hypofractionated radiotherapy and concomitant TMZ (75 mg/m2 ), and 14 of 18 patients received maintenance TMZ...
May 23, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29789974/a-prospective-feasibility-study-applying-the-acosog-z0011-criteria-to-japanese-patients-with-early-breast-cancer-undergoing-breast-conserving-surgery
#20
Nobuyoshi Kittaka, Ryu Tokui, Chika Ota, Yoko Hashimoto, Kazuyoshi Motomura, Makoto Ishitobi, Takahiro Nakayama, Yasuhiro Tamaki
BACKGROUND: In patients undergoing breast-conserving surgery and having positive sentinel lymph nodes (SLNs), the ACOSOG Z0011 trial showed equivalent loco-regional outcomes for patients receiving SLN dissection (SLND) alone and those receiving axillary lymph node dissection (ALND). We conducted a prospective single-arm study to confirm the applicability of the Z0011 criteria to Japanese patients with breast cancer. METHODS: Patients meeting the Z0011 inclusion criteria and providing consent to receive no additional ALND were prospectively enrolled at the Osaka International Cancer Institute from April 2012 to December 2016...
May 22, 2018: International Journal of Clinical Oncology
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