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International Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/30218412/burden-of-cardiovascular-disease-in-japanese-cancer-patients-and-survivors-a-single-cancer-center-study-in-niigata-city
#1
Yuji Okura, Tsugumi Takayama, Kazuyuki Ozaki, Hiroshi Tanaka, Hiroshi Seki, Tatsuya Takenouchi, Nobuaki Sato, Tohru Minamino
BACKGROUND: Cardiovascular disease (CVD) and cancer are major causes of death in Japan. As most CVDs are chronic and often aggravate, long-term follow-up is necessary. Although some cancer patients and survivors have CVD, its prognostic significance and prevalence are unknown. Therefore, we conducted a retrospective study at our center to determine the prevalence of cancer patients with CVD. METHODS: In 2015, our 10-year (2005-2014) cancer registry was summarized...
September 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30218411/correlations-between-cyp3a4-polymorphism-and-susceptibility-to-breast-cancer-in-chinese-han-population
#2
Xu Liu, Xi Huang, Shanshan Zhang, Fanglin Niu, Yongri Ouyang, Zhexing Shou, Jikui Liu
BACKGROUND: CYP3A4 is a major enzyme catalyzing the metabolism of endogenous steroids that play an important role in the etiology of carcinogenesis. This study was designed to investigate the contribution of CYP3A4 polymorphism to breast cancer in Chinese Han female population. METHODS: To examine whether variants of CYP3A4 contribute to breast cancer, 5 single-nucleotide polymorphisms (SNPs) of CYP3A4 were genotyped by Sequenom MassARRAY in 267 breast cancer patients and 302 healthy controls...
September 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30168090/long-term-influence-of-adjuvant-breast-radiotherapy-on-cognitive-function-in-breast-cancer-patients-treated-with-conservation-therapy
#3
Osamu Shibayama, Kazuhiro Yoshiuchi, Masatoshi Inagaki, Yutaka Matsuoka, Eisho Yoshikawa, Yuriko Sugawara, Tatsuo Akechi, Noriaki Wada, Shigeru Imoto, Koji Murakami, Asao Ogawa, Yosuke Uchitomi
BACKGROUND: The mechanisms underlying cognitive decline after radiotherapy not directed at brain areas remains unclear. We previously suggested that adjuvant breast radiotherapy in breast conservation therapy could lower memory function soon after therapy, and that the process might be partially mediated by plasma interleukin (IL)-6 levels. The present study investigated how that relationship changes longitudinally. METHODS: We performed the Wechsler Memory Scale-Revised (WMS-R) test and measured plasma IL-6 levels for 47 breast cancer surgical patients within 1 year after the initial therapy (study 1) and more than 2 years after study 1 (study 2)...
August 30, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30168088/predicting-marker-for-early-progression-in-unresectable-melanoma-treated-with-nivolumab
#4
Tomohiro Kondo, Motoo Nomura, Atsushi Otsuka, Yumi Nonomura, Yo Kaku, Shigemi Matsumoto, Manabu Muto
BACKGROUND: The objective of this study was to identify predictive markers, including inflammatory and nutritional status measures, of early progressive disease (EPD) in unresectable melanoma patients treated with nivolumab. METHODS: A retrospective review was performed on 39 consecutive patients with unresectable melanoma treated with nivolumab. EPD was defined as progressive disease within 60 days after starting nivolumab according to Response Evaluation Criteria in Solid Tumors version 1...
August 30, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30159691/significance-of-re-biopsy-of-histological-tumor-samples-in-advanced-non-small-cell-lung-cancer-in-clinical-practice
#5
REVIEW
Katsuyuki Hotta, Kiichiro Ninomiya, Eiki Ichihara, Katsuyuki Kiura
The significance of evaluating oncogenes, including EGFR mutations, ALK abnormalities, and PD-L1 expression has become broadly recognized with recent advances in molecular biology. It is now extremely important to investigate tumor oncogene status in each patient at the initial diagnosis. By contrast, the significance of conducting a re-biopsy in the salvage setting has not been systematically reviewed. This review reports that the significance of a re-biopsy varies depending on the clinical situation.
August 29, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30168089/prognostic-and-predictive-value-of-plasma-d-dimer-levels-in-patients-with-small-cell-lung-cancer
#6
Cuicui Zhang, Yongsheng Jia, Yanan Jia, Xiaoling Zhang, Kai Li
BACKGROUND: To investigate the predictive value of plasma D-dimer levels for short-term therapeutic effect and progression-free survival (PFS) in patients with small-cell lung cancer (SCLC); and to analyze the correlation between baseline plasma D-dimer levels and other clinicopathological features. The aim of the study was to investigate whether the levels of plasma D-dimer could serve as a predictive and prognostic factor in patients with SCLC. METHODS: A retrospective review of the clinicopathological data of 160 patients with pathologically confirmed SCLC, who were treated at the Department of Thoracic Oncology of Tianjin Medical University Tumor Institute and Hospital between June 2011 and June 2016, was performed...
August 27, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30145745/effect-of-combination-of-pre-and-postoperative-pulmonary-rehabilitation-on-onset-of-postoperative-pneumonia-a-retrospective-cohort-study-based-on-data-from-the-diagnosis-procedure-combination-database-in-japan
#7
Shuhei Fujimoto, Takeo Nakayama
BACKGROUND: To examine the effect of rehabilitation on postoperative pulmonary complication when it is conducted in combination of both before and after lung cancer surgery, as compared with either before or after surgery and no rehabilitation. METHODS: A retrospective cohort study was conducted to examine the effect of rehabilitation before and after lung cancer surgery on the causes of postoperative pneumonia. Data were collected from the diagnosis procedure combination (DPC) database...
August 25, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30143906/current-status-of-projects-for-developing-cancer-related-clinical-practice-guidelines-in-japan-and-recommendations-for-the-future
#8
Masafumi Imamura, Koichi Hirata, Michiaki Unno, Kinj Kamiya, Mitsukazu Gotoh, Hiroyuki Konno, Akiko Shibata, Kenichi Sugihara, Arata Takahashi, Masahiko Nishiyama, Kenichi Hakamada, Tsuguya Fukui, Toshiharu Furukawa, Tsunekazu Mizushima, Masamichi Mizuma, Hiroaki Miyata, Masaki Mori, Ichiro Takemasa, Toru Mizuguchi, Toshiyoshi Fujiwara
BACKGROUND: The current status and adoption of cancer-related clinical practice guidelines in Japan has not been elucidated yet. The purpose of this study was to propose roles and suggestions to develop future cancer-related clinical guidelines. METHODS: A questionnaire consisting of four domains with a total of 17 questions was developed. We distributed the questionnaire to 28 specific academic organizations in Japan which have developed any cancer-related clinical practice guidelines and which were funded by the Ministry of Health, Labor, and Welfare...
August 24, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30128722/recognition-and-attitudes-of-japanese-hematologists-on-sperm-banking-before-chemotherapy-present-status-from-nationwide-questionnaire-survey
#9
Yasushi Yumura, Akira Tsujimura, Hiroshi Okada, Kuniaki Ota, Masahumi Kitazawa, Tatsuya Suzuki, Toshiyuki Kakinuma, Chie Watanabe, Seido Takae, Nao Suzuki, Teruaki Iwamoto
BACKGROUND: Treatment advancements have improved young cancer patients' survival rate considerably. Fertility preservation has become a very important tool in the prevention of treatment-induced gonadal toxicity. This study aimed to examine hematologists' awareness of its necessity and importance. METHODS: Questionnaires were mailed to the directors of 230 institutes that treated hematological malignancies in adults. The directors were asked to provide information regarding their institutes, collaboration with sperm banks, the number of patients treated per year, selection criteria for patients providing information, and their awareness of and attitudes toward sperm preservation...
August 20, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30121869/role-of-intensive-nutrition-support-and-prophylactic-percutaneous-endoscopic-gastrostomy-during-concomitant-chemoradiotherapy-for-oropharyngeal-cancer
#10
Miki Takahashi, Nana Kosaka, Emi Wakui, Shinobu Iwaki, Mika Nishii, Masanori Teshima, Hirotaka Shinomiya, Koichi Morimoto, Naomi Kiyota, Ryohei Sasaki, Makoto Usami, Naoki Otsuki, Ken-Ichi Nibu
BACKGROUND: Concomitant chemoradiotherapy (CCRT) produces severe mucositis and swallowing dysfunction, often resulting in malnutrition. Intensive nutrition support (INS) in addition to percutaneous endoscopic gastrostomy (PEG) is reported to decrease adverse effects during CCRT. PATIENTS AND METHODS: Fifty-eight patients with oropharyngeal cancer treated by CDDP-based CCRT were retrospectively analyzed. Twenty-nine patients treated with INS in addition to PEG were classified as INS group, and other 29 patients treated with PEG but without INS were classified as control group...
August 18, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30109544/phase-ii-feasibility-study-of-preoperative-concurrent-chemoradiotherapy-with-cisplatin-plus-5-fluorouracil-and-elective-lymph-node-irradiation-for-clinical-stage-ii-iii-esophageal-squamous-cell-carcinoma
#11
Jun Hashimoto, Ken Kato, Yoshinori Ito, Takashi Kojima, Tetsuo Akimoto, Hiroyuki Daiko, Yasuo Hamamoto, Hisayuki Matsushita, Susumu Katano, Hiroki Hara, Yoichi Tanaka, Yoshihiro Saito, Kengo Nagashima, Hiroyasu Igaki
BACKGROUND: Preoperative chemoradiotherapy (CRT) is a standard treatment for stage II/III esophageal cancer. Preoperative chemotherapy is also considered a standard treatment for stage II/III esophageal squamous cell carcinoma (ESCC) in patients who undergo radical lymph node dissection. We conducted a feasibility study of preoperative CRT with cisplatin plus 5-fluorouracil (CF) and elective lymph node irradiation followed by esophagectomy with radical lymph node dissection in patients with stage II/III ESCC...
August 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30109543/prognostic-significance-of-neutrophil-lymphocyte-ratio-nlr-and-correlation-with-pet-ct-metabolic-parameters-in-small-cell-lung-cancer-sclc
#12
Cem Mirili, Isa Burak Guney, Semra Paydas, Gulsah Seydaoglu, Tuba Korkmaz Kapukaya, Ali Ogul, Serkan Gokcay, Mahmut Buyuksimsek, Abdullah Evren Yetisir, Bilgin Karaalioglu, Mert Tohumcuoglu
PURPOSE: The aim of this study is to detect the prognostic significance of neutrophil/lymphocyte ratio (NLR) in SCLC and to evaluate the relation with 18F-FDG PET-CT metabolic parameters (PET-CT MPs). METHODS: Demographic parameters, laboratory values including NLR and other clinical variables were analyzed in 112 patients with small cell lung cancer (SCLC) and 54 of these patients had results of metabolic parameters detected with 18 FDG PET-CT [including SUVmax , SUVmean , metabolic tumor volume (MTV), whole body MTV (WBMTV), TLG (total lesion glycolysis), whole body TLG (WBTLG)] were evaluated for survival analyses...
August 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30101389/preoperative-predictors-of-difficult-hypopharyngeal-exposure-by-retractor-for-transoral-robotic-surgery
#13
Kazunori Fujiwara, Satoshi Koyama, Ryouhei Donishi, Takahiro Fukuhara, Naritomo Miyake, Hiromi Takeuchi
INTRODUCTION: Transoral endoscopic surgeries provide excellent oncologic outcomes while preserving speech and swallowing ability. However, feasibility has been a major concern about transoral surgery. Therefore, ensuring visualization of the surgical field and sufficient working space is required. The aim of this study was to evaluate the parameters in the preoperative assessment that affect hypopharyngeal exposure. METHODS: Before transoral surgery, parameters regarding the patient's neck and face such as modified Mallampati index, thyroid-mental distance (TMD), and ability to fully open the mouth were evaluated...
August 13, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30099697/low-dose-gamma-knife-radiosurgery-plus-whole-brain-radiation-therapy-for-patients-with-5-or-more-brain-metastases-with-or-without-meningeal-dissemination
#14
Akifumi Miyakawa, Yuta Shibamoto, Shinya Takemoto, Tatsuo Hirai, Toru Serizawa
PURPOSE/OBJECTIVE(S): Radiosurgery plus whole-brain radiotherapy (WBRT) has been reported to be useful for patients with ≤ 4 brain metastases (BM), but we hypothesized that similar treatment may be applicable to patients with ≥ 5 BM with or without meningeal dissemination. The purpose of this study was to evaluate the efficacy and toxicity of low-dose Gamma Knife (GK) followed by WBRT for patients with advanced BM. MATERIALS/METHODS: Major eligibility criteria for this phase II study were: (1) ≥ 5 BM with or without meningeal dissemination and (2) the largest tumor diameter ≤ 4 cm...
August 11, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30094694/prognostic-outcome-and-complications-of-sentinel-lymph-node-navigation-surgery-for-early-stage-cervical-cancer
#15
Hideaki Yahata, Hiroaki Kobayashi, Kenzo Sonoda, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Ichiro Onoyama, Eisuke Kaneki, Kaoru Okugawa, Shingo Baba, Takuro Isoda, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato
BACKGROUND: To evaluate the prognostic outcome and surgical complications in patients with early-stage cervical cancer who underwent sentinel node navigation surgery (SNNS) for hysterectomy or trachelectomy. METHODS: A total of 139 patients who underwent SNNS using 99m Tc phytate between 2009 and 2015 were evaluated. No further lymph node dissection was performed when intraoperative analysis of the sentinel lymph nodes (SLNs) was negative for metastasis. We compared the surgical complications between the SNNS group and 67 matched patients who underwent pelvic lymph node dissection (PLND) after SLN mapping between 2003 and 2008...
August 9, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30094693/results-of-weekday-on-and-weekend-off-administration-schedule-of-sunitinib-therapy-for-advanced-renal-cell-carcinoma
#16
Atsunari Kawashima, Motohide Uemura, Taigo Kato, Takeshi Ujike, Akira Nagahara, Kazutoshi Fujita, Ryoichi Imamura, Yohei Yamanaka, Eisuke Tomiyama, Go Tanigawa, Yasushi Miyagawa, Toshiaki Yoshioka, Osamu Miyake, Norio Nonomura
BACKGROUND: Sunitinib is widely prescribed as first-line therapy for metastatic renal cell carcinoma. To reduce the ratio of severe adverse events and improve the relative dose intensity, we prospectively tried our own alternative medication schedule, which we called the "weekday-on and weekend-off regimen". Here we report the results of this regimen compared to the conventional medication schedule. METHODS: In total, 58 patients were enrolled in this study...
August 9, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30083964/does-tumour-effraction-during-robotic-partial-nephrectomy-have-any-impact-on-recurrence
#17
Zine-Eddine Khene, Benoit Peyronnet, Benjamin Pradère, Corentin Robert, Anna Goujon, Solène-Florence Kammerer-Jacquet, Grégory Verhoest, Nathalie Rioux-Leclercq, Romain Mathieu, Karim Bensalah
OBJECTIVE: To evaluate the impact of accidental surgical incision into the tumour (ASIT) on oncological outcomes in patients undergoing RPN for a malignant tumour. MATERIALS AND METHODS: A retrospective review of our prospectively maintained database was performed to identify all patients who underwent RPN for a localized RCC between June 2010 and July 2016. We stratified our cohort into two groups according to the presence of an ASIT. Perioperative data were compared between the two groups...
August 6, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30078140/analysis-and-treatment-of-45-platinum-allergic-gynecologic-malignant-tumors
#18
Xiaolin Ma, Xiuqin Li
BACKGROUND: This study aimed to explore the potential risk factors of platinum allergy and follow-up treatment to provide a reference for the clinical prevention and treatment of platinum allergic reactions in patients with gynecological tumors. METHODS: The study retrospectively analyzed 45 cases of platinum allergic reactions that occurred in Shengjing Hospital affiliated to China Medical University from August 2010 to July 2016. Analysis of risk factors included the cumulative dose, treatment course and time intervals...
August 4, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30074104/novel-graded-prognostic-assessment-for-colorectal-cancer-patients-with-brain-metastases
#19
Byoung Hyuck Kim, Hae Jin Park, Kyubo Kim, Sae-Won Han, Tae-You Kim, Seung-Yong Jeong, Kyu Joo Park, Eui Kyu Chie
PURPOSE: It is important to take into account potential prognostic factors to select patients with brain metastasis from colorectal cancer (CRC) who will benefit from active neurosurgical treatment. Therefore, we experimentally investigated our single institutional data to develop a novel CRC-specific graded prognostic assessment (GPA) and to help clinicians determine the optimal management. METHODS AND MATERIALS: We retrospectively reviewed the records of 107 patients with brain metastases from CRC who received any kind of treatment in our hospital and had sufficient clinical information...
August 3, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30069798/effect-of-everolimus-treatment-for-regrown-renal-angiomyolipoma-associated-with-tuberous-sclerosis-complex-after-transcatheter-arterial-embolization
#20
Takashi Hatano, Taishi Matsu-Ura, Kei-Ichiro Mori, Hiroyuki Inaba, Katsuhisa Endo, Mayumi Tamari, Shin Egawa
BACKGROUND: The aim of this study was to evaluate the effects and the utility of second-line everolimus treatment for regrown renal angiomyolipoma (AML) with tuberous sclerosis complex (TSC) after transcatheter arterial embolization (TAE). METHODS: We investigated a total of 14 patients who underwent second-line everolimus treatment for TSC-AML that regrew after TAE, and assessed their effects and adverse events. Everolimus treatment was performed for AML with a maximum diameter of 4 cm...
August 1, 2018: International Journal of Clinical Oncology
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