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International Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/29789974/a-prospective-feasibility-study-applying-the-acosog-z0011-criteria-to-japanese-patients-with-early-breast-cancer-undergoing-breast-conserving-surgery
#1
Nobuyoshi Kittaka, Ryu Tokui, Chika Ota, Yoko Hashimoto, Kazuyoshi Motomura, Makoto Ishitobi, Takahiro Nakayama, Yasuhiro Tamaki
BACKGROUND: In patients undergoing breast-conserving surgery and having positive sentinel lymph nodes (SLNs), the ACOSOG Z0011 trial showed equivalent loco-regional outcomes for patients receiving SLN dissection (SLND) alone and those receiving axillary lymph node dissection (ALND). We conducted a prospective single-arm study to confirm the applicability of the Z0011 criteria to Japanese patients with breast cancer. METHODS: Patients meeting the Z0011 inclusion criteria and providing consent to receive no additional ALND were prospectively enrolled at the Osaka International Cancer Institute from April 2012 to December 2016...
May 22, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29785621/comparison-of-efficacy-and-toxicity-of-second-line-combination-chemotherapy-regimens-in-patients-with-advanced-urothelial-carcinoma
#2
Yuji Takeyama, Minoru Kato, Chikako Nishihara, Takeshi Yamasaki, Taro Iguchi, Satoshi Tamada, Katsuyuki Kuratsukuri, Tatsuya Nakatani
BACKGROUND: The aim of this study was to evaluate the efficacy and toxicities of second-line chemotherapy regimens with docetaxel and gemcitabine (GD), or paclitaxel and gemcitabine (GP) for advanced or metastatic urothelial carcinoma (UC) that did not respond to first-line platinum-based chemotherapy. METHODS: From 2002 to 2017, 78 patients with metastatic UCs that progressed after platinum-based chemotherapy were treated with either GD (n = 41) or GP (n = 37)...
May 21, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29785620/how-asymptomatic-are-early-cancer-patients-of-five-organs-based-on-registry-data-in-japan
#3
Narue Nakabayashi, Masahiro Hirose, Ritsuro Suzuki, Junji Suzumiya, Mikio Igawa
BACKGROUND: One reason for the low cancer screening rate in Japan is that people are not concerned about cancer if they do not have symptoms. METHODS: The authors retrospectively analyzed 18,405 cancer patients using hospital-based cancer registry data collected between 2007 and 2013 at the 13 hospitals of Shimane Prefecture, Japan. The symptomatic rates of five cancers (stomach, colorectal, lung, breast, and cervix) at each stage and the time of early diagnosis were investigated...
May 21, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29779136/genetic-mutation-analysis-of-the-malignant-transformation-of-sinonasal-inverted-papilloma-by-targeted-amplicon-sequencing
#4
Shinichiro Yasukawa, Satoshi Kano, Hiromitsu Hatakeyama, Yuji Nakamaru, Dai Takagi, Takatsugu Mizumachi, Masanobu Suzuki, Takayoshi Suzuki, Akira Nakazono, Shinya Tanaka, Hiroshi Nishihara, Akihiro Homma
BACKGROUND: The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. METHODS: To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. RESULTS: The number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular...
May 19, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29777315/the-mdm2-rs937283-a-g-variant-significantly-increases-the-risk-of-lung-and-gastric-cancer-in-chinese-population
#5
Bifeng Chen, Jieling Wang, Yucan Chen, Xiuli Gu, Xianhong Feng
BACKGROUND: Currently, the MDM2 promoter rs937283 A > G variant that is able to alter MDM2 gene expression has been widely studied to explore the association of MDM2 with cancer risk. In this report, we investigate the association of MDM2 rs937283 A > G variant with risk of lung cancer (LC) and gastric cancer (GC) in a Chinese population of Hubei province, which was followed by a meta-analysis. METHODS: The genotyping of rs937283 was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing...
May 18, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29774484/effect-of-post-filter-anticoagulation-on-mortality-in-patients-with-cancer-associated-pulmonary-embolism
#6
Jieun Kang, Seon Ok Kim, Yeon-Mok Oh, Sang-Do Lee, Jae Seung Lee
BACKGROUND: Malignancy is associated with an increased risk of venous thromboembolism. Inferior vena cava filters are a viable alternative when anticoagulation is infeasible because of the risk of bleeding. Although the current guidelines recommend that all patients with a vena cava filter be treated with anticoagulation treatment when the risk of bleeding is reduced, studies concerning the role of concomitant anticoagulation after vena cava filter insertion in high-risk patients are scarce...
May 17, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29774483/analysis-of-unexplained-carcinoembryonic-antigen-elevation-after-curative-treatment-of-locally-advanced-rectal-cancer
#7
Sung Uk Lee, Eunjin Jwa, Dae Yong Kim, Tae Hyun Kim, Ji Yeon Baek, Yongjun Cha, Hee Jin Chang, Jae Hwan Oh
BACKGROUND: To analyze the causes and patterns of unexplained carcinoembryonic antigen (CEA) elevation after curative treatment in locally advanced rectal cancer patients. METHODS: Among the 1309 locally advanced rectal cancer patients treated with curative resection and radiotherapy between January 2001 and June 2011, 325 patients who postoperatively developed abnormal CEA elevation were reviewed. The unexplained CEA elevation was defined as a CEA level higher than 5 ng/mL with no evidence of cancer recurrence at the time of elevation...
May 17, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29761307/intravesical-bacillus-calmette-guerin-therapy-after-second-transurethral-resection-for-primary-t1-bladder-cancer
#8
Masato Baba, Susumu Kageyama, Tetsuya Yoshida, Ryo Fujiwara, Chul Jang Kim, Keita Takimoto, Masayuki Nagasawa, Hiroki Soga, Yukihiro Nagatani, Zenkai Nishikawa, Akihiro Kawauchi
BACKGROUND: To evaluate the effect of intravesical bacillus Calmette-Guerin (BCG) instillation therapy after second transurethral resection (TUR) on primary T1 bladder cancer. METHODS: The subjects were 180 patients diagnosed with T1 bladder cancer at our university and at affiliated hospitals between January 1990 and December 2015. Tumor residual rate, intravesical recurrence rate, and risk factors for intravesical recurrence were investigated. RESULTS: The median follow-up period was 26 (1-175) months...
May 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29761306/low-expression-of-cd40l-in-tumor-free-lymph-node-of-oral-cavity-cancer-related-with-poor-prognosis
#9
Yoon Chan Rah, Jae-Cheul Ahn, Eun-Hui Jeon, Hyojin Kim, Jin Ho Paik, Woo-Jin Jeong, Soon-Young Kwon, Soon-Hyun Ahn
BACKGROUND: Recently, the genetic alterations associated with tumor progression and impaired host immunity against transformed cells draw increased attention. Here, we characterized the differential gene expression patterns and protein expression in tumor-free lymph node from recurrent and non-recurrent tumors to identify independent prognostic markers for oral squamous cell carcinoma (OSCC). METHODS: A cDNA microarray analysis was performed to identify the differentially expressed genes in regional tumor-free lymph nodes from OSCC patients with and without recurrence...
May 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29752605/influence-of-incomplete-neoadjuvant-chemotherapy-on-esophageal-carcinoma
#10
Yushi Fujiwara, Shigeru Lee, Satoru Kishida, Ryoya Hashiba, Ken Gyobu, Ryoko Naka, Masaki Nishiyama, Toshio Ihara, Masashi Takemura, Harushi Osugi
BACKGROUND: Neoadjuvant chemotherapy (NAC) involving two cycles of cisplatin plus fluorouracil is recommended in Japan as a standard treatment for resectable, locally advanced esophageal squamous cell carcinoma (ESCC). We have encountered patients who were administered incomplete chemotherapy because of adverse events or the patient's refusal of treatment. Here, we retrospectively investigated the influence on perioperative outcomes and long-term prognosis of patients with ESCC who underwent complete (two cycles) or incomplete (one cycle) NAC...
May 11, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29749579/in-vivo-detection-of-acute-intracellular-acidification-in-glioblastoma-multiforme-following-a-single-dose-of-cariporide
#11
Mohammed Albatany, Alex Li, Susan Meakin, Robert Bartha
Glioblastoma is an aggressive brain cancer that is very difficult to treat. Clinically, it is important to be able to distinguish aggressive from non-aggressive brain tumors. Previous studies have shown that some drugs can induce a rapid change in intracellular pH that could help to identify aggressive cancer. The sodium proton exchanger (NHE1) plays a significant role in maintaining pH balance in the tumor microenvironment. Cariporide is a sodium proton exchange inhibitor that is well tolerated by humans in cardiac applications...
May 10, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29744604/rapid-decrease-of-serum-alpha-fetoprotein-and-tumor-volume-predicts-outcome-in-children-with-hepatoblastoma-treated-with-neoadjuvant-chemotherapy
#12
Rosa Nguyen, M Beth McCarville, April Sykes, Shenghua Mao, Jianrong Wu, Max R Langham, Wayne L Furman
BACKGROUND: Neoadjuvant chemotherapy is given to children with unresectable hepatoblastoma to increase the rate and safety of curative complete surgical resection. Elevated levels of serum alpha-fetoprotein (sAFP) decline with tumor shrinkage. In this single-institution retrospective study, we determined early dynamic changes of sAFP levels and tumor volume in children during therapy for unresectable hepatoblastoma. METHODS: We correlated early dynamic changes of sAFP levels and tumor volume and the sum of the longest primary tumor and measurable metastatic disease diameters as per RECIST 1...
May 9, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29744603/introduction-lynch-syndrome-its-molecular-mechanism-and-current-topics
#13
REVIEW
Naohiro Tomita
No abstract text is available yet for this article.
May 9, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29744602/current-clinical-topics-of-lynch-syndrome
#14
REVIEW
Kohji Tanakaya
Lynch syndrome (LS) is one of the most common genetic cancer syndromes, occurring at a rate of 1 per 250-1000 in the general population. This autosomal dominant disease is caused by a germline variant in one of the four mismatch repair genes, MSH2, MLH1, MSH6, PMS2, or the EPCAM gene. LS develops at early ages in colorectal cancer (CRC), endometrial cancer, and various other associated tumors. Accurate diagnosis of LS and utilization of various risk-reduction strategies such as surveillance, prophylactic surgery, and chemoprevention could improve clinical outcomes...
May 9, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29713911/early-intervention-using-high-precision-radiotherapy-preserved-visual-function-for-five-consecutive-patients-with-optic-nerve-sheath-meningioma
#15
Toshihiko Inoue, Osamu Mimura, Norihisa Masai, Atuyuki Ohashi, Koji Ikenaga, Yoshishige Okuno, Iku Nishiguchi, Ryoongjin Oh
BACKGROUND: There has been a paradigm shift in the treatment for optic nerve sheath meningioma (ONSM) from surgery to fractionated stereotactic radiotherapy (FSRT) in other countries. However, FSRT has seldom been performed in Japan. The purpose of this retrospective study is to reconfirm the effectiveness of early intervention with precision radiotherapy for ONSM reported in our previous study. METHODS: Five consecutive patients with ONSM were retrospectively analyzed...
April 30, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29713910/employment-status-and-termination-among-survivors-of-pediatric-brain-tumors-a-cross-sectional-survey
#16
Iori Sato, Akiko Higuchi, Takaaki Yanagisawa, Shiho Murayama, Toshihiro Kumabe, Kazuhiko Sugiyama, Akitake Mukasa, Nobuhito Saito, Yutaka Sawamura, Mizuhiko Terasaki, Soichiro Shibui, Jun Takahashi, Ryo Nishikawa, Yasushi Ishida, Kiyoko Kamibeppu
BACKGROUND: Some childhood cancer survivors experience employment difficulties. This study aimed to describe pediatric brain-tumor survivors' employment status. METHODS: A cross-sectional, observational study was conducted, with questionnaires distributed to 101 pediatric brain-tumor survivors (aged 15 years or older) and their attending physicians from nine institutions in Japan. We compared category and time-series histories for participants' first-time employment using national census information...
April 30, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29705976/feasibility-study-of-postoperative-adjuvant-chemotherapy-with-s-1-in-patients-with-biliary-tract-cancer
#17
Kohei Nakachi, Masaru Konishi, Masafumi Ikeda, Kazuaki Shimada, Takuji Okusaka, Akio Saiura, Hiroshi Ishii, Masanori Sugiyama, Junji Furuse, Hirohiko Sakamoto, Tomotaka Shimamura, Takehiro Ohta
BACKGROUND: The role of adjuvant chemotherapy has not yet been established for patients with resected biliary tract cancer. S-1 has been shown to exert activity against advanced biliary tract cancer. Therefore, we evaluated the feasibility of adjuvant chemotherapy with S-1 in patients with resected biliary tract cancer. METHODS: Patients with complete macroscopic resection of intrahepatic/extrahepatic bile duct, gall bladder, or ampullary cancer were eligible. S-1 was administered orally twice daily for 4 weeks every 6 weeks, up to 4 cycles...
April 28, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29700636/results-of-a-phase-ii-trial-for-high-risk-neuroblastoma-treatment-protocol-jn-h-07-a-report-from-the-japan-childhood-cancer-group-neuroblastoma-committee-jnbsg
#18
Tomoro Hishiki, Kimikazu Matsumoto, Miki Ohira, Takehiko Kamijo, Hiroyuki Shichino, Tatsuo Kuroda, Akihiro Yoneda, Toshinori Soejima, Atsuko Nakazawa, Tetsuya Takimoto, Isao Yokota, Satoshi Teramukai, Hideto Takahashi, Takashi Fukushima, Takashi Kaneko, Junichi Hara, Michio Kaneko, Hitoshi Ikeda, Tatsuro Tajiri, Akira Nakagawara
BACKGROUND: The Japanese Children's Cancer Group (JCCG) Neuroblastoma Committee (JNBSG) conducted a phase II clinical trial for high-risk neuroblastoma treatment. We report the result of the protocol treatment and associated genomic aberration studies. METHODS: JN-H-07 was a single-arm, late phase II trial for high-risk neuroblastoma treatment with open enrollment from June 2007 to February 2009. Eligible patients underwent five courses of induction chemotherapy followed by high-dose chemotherapy with hematopoietic stem cell rescue...
April 26, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29691673/multi-panel-assay-of-serum-autoantibodies-in-colorectal-cancer
#19
Mitsunori Ushigome, Yoshihiro Nabeya, Hiroaki Soda, Nobuhiro Takiguchi, Akiko Kuwajima, Masatoshi Tagawa, Kazuyuki Matsushita, Junichi Koike, Kimihiko Funahashi, Hideaki Shimada
BACKGROUND: Although serum p53 autoantibodies (s-p53-Abs) are induced even in the early stages of colorectal cancer, their positive rate is only approximately 20%. Therefore, we assessed the possibility of using other serum autoantibodies to increase the positive rates for detecting colorectal cancer. METHODS: Autoantibodies against 17 tumor antigens (p53, RalA, HSP70, Galectin1, KM-HN-1, NY-ESO-1, p90, Sui1, HSP40, CyclinB1, HCC-22-5, c-myc, PrxVI, VEGF, HCA25a, p62, and Annexin II) were evaluated in 279 patients with colorectal cancer and 74 healthy controls...
April 24, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29679177/impact-of-the-number-of-removed-lymph-nodes-on-recurrence-free-survival-in-stage-i-ovarian-clear-cell-carcinoma
#20
Yuji Takei, Suzuyo Takahashi, Shizuo Machida, Akiyo Taneichi, Takahiro Yoshiba, Yoshifumi Takahashi, Chikako Yoshida, Yasushi Saga, Shigeki Matsubara, Hiroyuki Fujiwara
BACKGROUND: Although there have been several reports regarding the significance of staging lymphadenectomy for early stage ovarian clear cell carcinoma (CCC) patients, there have been few reports focusing on the number of removed lymph nodes. The aim of this study was to evaluate the impact of the number of removed lymph nodes on recurrence-free survival (RFS) in stage I ovarian CCC. METHODS: The subjects were patients with ovarian CCC who underwent surgery between January 1988 and December 2013...
April 20, 2018: International Journal of Clinical Oncology
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