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International Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/28220335/multivariate-evaluation-of-thyroid-imaging-reporting-and-data-system-ti-rads-in-diagnosis-malignant-thyroid-nodule-application-to-pca-and-pls-da-analysis
#1
Tan Zhang, Fangxuan Li, Jiali Mu, Juntian Liu, Sheng Zhang
OBJECTIVE: To explore the significance of ultrasonic features in differential diagnosis of thyroid nodules via combining the thyroid imaging reporting and data system (TI-RADS) and multivariate statistical analysis. METHODS: Patients who received surgical treatment and was diagnosed with single thyroid nodule by postoperative pathology and preoperative ultrasound were enrolled in this study. Multivariate analysis was applied to assess the significant ultrasonic features which correlated with identifying benign or malignance and grading the TI-RADS classification of thyroid nodule...
February 20, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28213742/comparison-of-systemic-inflammatory-and-nutritional-scores-in-colorectal-cancer-patients-who-underwent-potentially-curative-resection
#2
Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Daisuke Izumi, Keisuke Kosumi, Katsunobu Taki, Takaaki Higashi, Tatsunori Miyata, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
BACKGROUND: Various systemic inflammatory and nutritional scores have been reported to predict postoperative outcomes. This study aimed to investigate the best systemic inflammatory and nutritional scores in colorectal cancer (CRC) patients who underwent potentially curative resection. METHOD: We evaluated 468 consecutive CRC patients in this study. Comparisons of systemic inflammatory and nutritional scores, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS), were performed using univariate/multivariate analyses for patient survival...
February 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28210822/plasma-dna-methylation-of-p16-and-shp1-in-patients-with-b-cell-non-hodgkin-lymphoma
#3
Kai Ding, Xiaoshuang Chen, Yihao Wang, Hui Liu, Wenjing Song, Lijuan Li, Guojin Wang, Jia Song, Zonghong Shao, Rong Fu
BACKGROUND: Early diagnosis and treatment of non-Hodgkin lymphoma (NHL) are progressively important. It has been shown that aberrant promoter methylation contributes to the development and progression of lymphoma. We tried to explore the effect of methylation of p16 and shp1 genes in plasma in the diagnosis of B-NHL patients. METHODS: The methylation of p16 and shp1 genes in plasma were detected by methylation specific polymerase chain reaction in 103 patients with B-NHL, and compared with peripheral blood leukocytes (PBLs) and formaldehyde-fixed paraffin-embedded (FFPE) tumor tissues...
February 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28205002/prognostic-impacts-of-postoperative-complications-in-patients-with-intrahepatic-cholangiocarcinoma-after-curative-operations
#4
Tatsunori Miyata, Yo-Ichi Yamashita, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kensuke Yamamura, Kota Arima, Takayoshi Kaida, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
BACKGROUND: The postoperative complication is one of an indicator of poor prognosis in patients with several gastroenterological cancers after curative operations. We, herein, examined prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations. METHODS: We retrospectively analyzed 60 patients with intrahepatic cholangiocarcinoma who underwent primary curative operations from June 2002 to February 2016...
February 15, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28188392/current-status-of-uterine-leiomyosarcoma-in-the-tohoku-region-results-of-the-tohoku-translational-center-development-network-survey
#5
Hideki Tokunaga, Fumiaki Takahashi, Hiroki Yamamoto, Tsuyoshi Honda, Takafumi Watanabe, Tadahiro Shoji, Toru Sugiyama, Hidekazu Yamada, Tomoe Tando, Kosuke Yoshinaga, Satoko Kagabu, Takeo Otsuki, Shogo Kin, Yoshihito Yokoyama, Satoshige Wagatsuma, Kazuyo Sato, Hirokazu Sato, Takashi Oishi, Yuji Yoshida, Tadashi Hayasaka, Toshihiko Matsui, Noriaki Imai, Hidekazu Nishigori, Hiroaki Shimokawa, Nobuo Yaegashi, Yoh Watanabe
BACKGROUND: To prepare for a future clinical trial for improving the long-term prognosis of patients with uterine leiomyosarcoma (ULMS), we conducted a multi-institutional survey in the Tohoku region of Japan. METHODS: We conducted a retrospective cohort study between 2011 and 2014 in member institutions of the Tohoku Translational Research Center Development Network. RESULTS: A total of 53 patients with ULMS were registered in 31 institutions for the present survey...
February 10, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28185020/natural-course-of-asymptomatic-abnormal-prostate-findings-incidentally-detected-by-ct-after-intravesical-bcg-therapy
#6
Masashi Matsushima, Eiji Kikuchi, Hirotaka Akita, Akira Miyajima, Mototsugu Oya, Masahiro Jinzaki
BACKGROUND: Detailed information is not currently available on the incidence, natural course, and management of asymptomatic abnormal prostate findings incidentally detected by radiologic evaluations after BCG therapy for non-muscle-invasive bladder cancer patients. METHODS: We identified 38 patients who were evaluated by contrast-enhanced CT scans before TUR-BT and after BCG therapy between 2006 and 2012. We evaluated the clinical courses of patients with abnormal radiologic findings of the prostate gland after BCG therapy...
February 10, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28176023/postoperative-weight-loss-leads-to-poor-survival-through-poor-s-1-efficacy-in-patients-with-stage-ii-iii-gastric-cancer
#7
Toru Aoyama, Tsutomu Sato, Yukio Maezawa, Kazuki Kano, Tsutomu Hayashi, Takanobu Yamada, Norio Yukawa, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Haruhiko Cho, Takaki Yoshikawa
AIMS: We previously demonstrated that body weight loss (BWL) at one month after gastrectomy, a common finding after surgery for gastric cancer, was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether BWL after gastrectomy leads to poor survival through poor compliance to adjuvant chemotherapy with S-1. METHODS: We conducted this follow-up study in the same cohort as our previous study. Overall survival (OS) and recurrence-free survival (RFS) were examined in 103 patients who underwent curative D2 surgery and were pathologically diagnosed with stage II or III gastric cancer, and who received postoperative adjuvant chemotherapy with S-1 between June 2002 and December 2011...
February 7, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28154951/reply-to-comments-from-vincent-et-al
#8
LETTER
Kazuo Tamura
No abstract text is available yet for this article.
February 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28144884/aprepitant-for-the-treatment-of-breakthrough-chemotherapy-induced-nausea-and-vomiting-in-patients-receiving-moderately-emetogenic-chemotherapy
#9
Takako Inoue, Madoka Kimura, Junji Uchida, Kazumi Nishino, Toru Kumagai, Junko Taniguchi, Fumio Imamura
BACKGROUND: Our aim was to evaluate the efficacy of oral aprepitant in rescue treatment after the primary rescue for breakthrough chemotherapy-induced nausea and vomiting (CINV) in chemotherapy-naive patients receiving moderately emetogenic chemotherapy (MEC). METHODS: This was a single-institutional phase 2 study. Patients who had received MEC regimens and developed breakthrough CINV despite antiemetic prophylaxis without aprepitant were treated with primary rescue antiemetic treatments chosen by physicians...
January 31, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28144883/retrospective-analysis-of-lung-cancer-patients-treated-with-supportive-care-alone
#10
Hironori Ashinuma, Masato Shingyoji, Yasushi Yoshida, Meiji Itakura, Toshihiko Iizasa, Yoshihiko Sakashita, Ikuo Sekine
BACKGROUND: It is not uncommon for patients with lung cancer to receive supportive care alone. However, the clinical characteristics of these patients have not been fully studied. We conducted a retrospective study to identify the clinical characteristics of definitive lung cancer patients treated with supportive care alone. METHODS: We retrospectively analyzed the percentage of and reasons for definitive lung cancer patients treated with supportive care alone at a regional cancer center...
January 31, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28144882/efficacy-and-toxicity-of-transarterial-chemoembolization-therapy-using-cisplatin-and-gelatin-sponge-in-patients-with-liver-metastases-from-uveal-melanoma-in-an-asian-population
#11
Yoshitsugu Shibayama, Kenjiro Namikawa, Miyuki Sone, Akira Takahashi, Arata Tsutsumida, Shunsuke Sugawara, Yasuaki Arai, Yukiko Aihara, Shigenobu Suzuki, Juichiro Nakayama, Shinichi Imafuku, Naoya Yamazaki
BACKGROUND: Although both immune-checkpoint inhibitors and targeted therapies such as MEK inhibitors have been evaluated in metastatic uveal melanoma, the efficacy of these therapies is modest to date. The purpose of this study was to evaluate the efficacy and toxicity of transarterial chemoembolization (TACE) therapy for liver metastasis from uveal melanoma in an Asian population. METHODS: We retrospectively assessed the clinical data of patients with liver metastases from uveal melanoma who received TACE therapy using cisplatin (70 mg/m(2)) and gelatin sponge between 1997 and 2008...
January 31, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28138878/preoperative-platelet-lymphocyte-ratio-is-an-independent-prognostic-marker-and-superior-to-carcinoembryonic-antigen-in-colorectal-peritoneal-carcinomatosis-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#12
Tiffany Sin Hui Bong, Grace Hwei Ching Tan, Claramae Chia, Khee Chee Soo, Melissa Ching Ching Teo
OBJECTIVE: The aim of this study was to examine the prognostic significance of preoperative inflammatory-based indices, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and carcinoembryonic antigen (CEA) in predicting overall survival (OS) in patients with colorectal peritoneal carcinomatosis (CPC) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: Sixty patients with pathologically confirmed CPC treated with CRS and HIPEC between 2003 and 2015 were included...
January 30, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28124284/incidence-of-and-risk-factors-associated-with-nedaplatin-related-hypersensitivity-reactions
#13
Yuki Kawarada, Masayuki Miyazaki, Ayaka Itoh, Risa Araki, Hidetaka Iwamizu, Tomomi Kataoka, Yasuo Kumakura, Akiko Ota, Taku Nagai, Kiyofumi Yamada
BACKGROUND: Nedaplatin (NDP)-related hypersensitivity reactions (HSRs) trigger adverse clinical events. Prediction and prevention of NDP-HSRs are thus essential to minimize the risk and maximize the benefit of NDP therapy. However, the incidence of NDP-HSRs and the associated risk factors remain unclear. METHODS: We retrospectively examined patients who received NDP monotherapy between April 2011 and July 2015 in Nagoya University Hospital. HSRs severity was defined according to the Common Terminology Criteria for Adverse Events version 4 (CTCAE ver...
January 25, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28101757/final-report-of-kscc0803-feasibility-study-of-capecitabine-as-adjuvant-chemotherapy-for-stage-iii-colon-cancer-in-japan
#14
Kazuhito Minami, Masaru Morita, Yasunori Emi, Masahiro Okamoto, Eiji Tanaka, Shigeyuki Nagata, Tetsuo Touyama, Kippei Ohgaki, Takaho Tanaka, Hiroshi Okumura, Toyokuni Suenaga, Shoji Tokunaga, Eiji Oki, Yoshihiro Kakeji, Yoshito Akagi, Hideo Baba, Shoji Natsugoe, Yoshihiko Maehara
BACKGROUND: The impact of oral capecitabine as adjuvant chemotherapy for Japanese patients with resected colon cancer was unclear. We previously planned and conducted a prospective feasibility study (KSCC0803) and reported on the safety of oral capecitabine as adjuvant chemotherapy for Japanese patients with resected stage III colon cancer. The purpose of the current study was to assess the survival results from that study. METHODS: The study subjects were Japanese patients with resected stage III colon cancer...
January 18, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28097441/elevated-preoperative-neutrophil-to-lymphocytes-ratio-predicts-poor-prognosis-after-esophagectomy-in-t1-esophageal-cancer
#15
Kenichi Nakamura, Naoya Yoshida, Yoshifumi Baba, Keisuke Kosumi, Tomoyuki Uchihara, Yuki Kiyozumi, Mayuko Ohuchi, Takatsugu Ishimoto, Masaaki Iwatsuki, Yasuo Sakamoto, Masayuki Watanabe, Hideo Baba
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) has been reported to predict the prognosis of various malignant tumors, including esophageal cancer. However, no previous reports have supported the use of the preoperative NLR as an independent prognostic marker focused on superficial (T1) esophageal cancer. The aim of this study was to elucidate the prognostic impact of the preoperative NLR in T1 esophageal cancer. METHODS: This retrospective study recruited 245 consecutive patients with T1 esophageal cancer who underwent subtotal esophagectomy between 2005 and 2016...
January 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28083737/histologic-grade-and-peritoneal-cytology-as-prognostic-factors-in-type-1-endometrial-cancer
#16
Kei Tanaka, Yoichi Kobayashi, Juri Sugiyama, Tatsuo Yamazaki, Kei Dozono, Momoe Watanabe, Hiromi Shibuya, Yoshiko Nishigaya, Mai Momomura, Hironori Matsumoto, Satoshi Umezawa, Kiyoshi Takamatsu, Mitsutoshi Iwashita
BACKGROUND: Prognostic clinicopathological factors for type 1 endometrial cancer are unknown and the purpose of the current study was to determine the independent prognostic variables for type 1 endometrial cancer. METHODS: We performed a retrospective study of 168 patients with type 1 endometrial cancer primarily treated with comprehensive staging surgery. The median follow-up time was 68 (12-100) months. Independent risk factors for disease-free survival (DFS) and overall survival (OS) were determined using multivariate Cox regression models...
January 12, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28078540/preplanned-safety-analysis-of-the-jfmc37-0801-trial-a-randomized-phase-iii-study-of-six-months-versus-twelve-months-of-capecitabine-as-adjuvant-chemotherapy-for-stage-iii-colon-cancer
#17
Takeshi Suto, Megumi Ishiguro, Chikuma Hamada, Katsuyuki Kunieda, Hiroyuki Masuko, Ken Kondo, Hideyuki Ishida, Genichi Nishimura, Kazuaki Sasaki, Takayuki Morita, Shoichi Hazama, Koutarou Maeda, Hideyuki Mishima, Hideyuki Ike, Sotaro Sadahiro, Kenichi Sugihara, Masazumi Okajima, Shigetoyo Saji, Junichi Sakamoto, Naohiro Tomita
BACKGROUND: Six months of adjuvant chemotherapy is regarded as the standard of care for patients with stage III colon cancer. However, whether longer treatment can improve prognosis has not been fully investigated. We conducted a phase III study comparing 6 and 12 months of adjuvant capecitabine chemotherapy for stage III colon cancer, and report here the results of our preplanned safety analysis. METHODS: Patients aged 20-79 years with curatively resected stage III colon cancer were randomly assigned to receive 8 cycles (6 months) or 16 cycles (12 months) of capecitabine (2500 mg/m(2)/day on days 1-14 of each 21-day cycle)...
January 11, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28074298/effect-of-intraoperative-radiotherapy-in-the-treatment-of-retroperitoneal-sarcoma
#18
Liz B Wang, David McAneny, Gerard Doherty, Teviah Sachs
BACKGROUND: Current National Comprehensive Cancer Network guidelines for the treatment of retroperitoneal sarcomas (RPS) endorse surgical resection, but the role of radiotherapy (RT) is less clear. We investigate the utilization and benefits of intraoperative RT (IORT) in the treatment of RPS. METHODS: We queried the Surveillance, Epidemiology and End Results (SEER) database (1988-2013) for the utilization of IORT and perioperative external beam RT (EBRT) in patients who underwent surgical resection of RPS...
January 10, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28064398/prognostic-significance-of-hyperfibrinogenemia-in-patients-with-esophageal-squamous-cell-carcinoma
#19
Takashi Suzuki, Hideaki Shimada, Tatsuki Nanami, Yoko Oshima, Satoshi Yajima, Naohiro Washizawa, Hironori Kaneko
BACKGROUND: Preoperative hyperfibrinogenemia is associated with inflammatory mediators and a poor prognosis in several types of cancer. However, there is no published information on the monitoring of patients with preoperative hyperfibrinogenemia after surgery. The aim of the study reported here was to assess the clinicopathological and prognostic significance of plasma fibrinogen levels in patients with esophageal squamous cell carcinoma before and after surgical treatment. METHODS: Plasma fibrinogen levels were analyzed before surgical treatment (endoscopic submucosal dissection and surgery) in 82 patients with esophageal squamous cell carcinoma...
January 7, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28064397/review-and-proposal-of-regional-surgical-management-for-melanoma-revisiting-of-integumentectomy-and-incontinuity-dissection-in-treatment-of-skin-melanoma
#20
Toshihiko Hayashi, Hiroshi Furukawa, Takashi Kitamura, Ryuji Shichinohe, Naoki Murao, Akihiko Oyama, Emi Funayama, Taku Maeda, Yuhei Yamamoto
BACKGROUND: Past studies showed that integumentectomy and incontinuity could be effective procedures in the surgical management of melanoma patients. The present study reports on the historical background of these procedures. In addition, we analyze the ICG assisted integumentectomy and incontinuity techniques and algorithms that we had created when performing this procedure. METHOD: In accordance with our algorithm, we performed ICG assisted integumentectomy/incontinuity procedures on 17 patients with stage III melanomas between 2008 and 2016...
January 7, 2017: International Journal of Clinical Oncology
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