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International Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/27909836/febuxostat-and-tumor-lysis-syndrome-an-indication-that-remains-unclear
#1
LETTER
F Vincent, A Dupré, C Mousseaux, C Bornstain, M Darmon
No abstract text is available yet for this article.
December 1, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27909835/breakthrough-chemotherapy-induced-nausea-and-vomiting-report-of-a-nationwide-survey-by-the-cinv-study-group-of-japan
#2
Kazuo Tamura, Keisuke Aiba, Toshiaki Saeki, Yoichi Nakanishi, Toshiharu Kamura, Hideo Baba, Kazuhiro Yoshida, Nobuyuki Yamamoto, Yuko Kitagawa, Yoshihiko Maehara, Mototsugu Shimokawa, Koichi Hirata, Masaki Kitajima
BACKGROUND: We conducted a nationwide survey on chemotherapy-induced nausea and vomiting (CINV) in Japan and demonstrated good compliance with Japanese CINV guidelines, resulting in good control of vomiting. However, almost half the patients experienced breakthrough CINV. We analyzed the survey results in relationship to the management of patients with breakthrough CINV. METHODS: This multicenter, prospective, observational study analyzed data for 1910 patients in Japan scheduled for moderately or highly emetogenic chemotherapy (MEC and HEC, respectively)...
December 1, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27896485/biomarkers-for-precision-medicine-in-bladder-cancer
#3
REVIEW
Takahiro Kojima, Koji Kawai, Jun Miyazaki, Hiroyuki Nishiyama
Bladder cancer (BC) is classified as non-muscle-invasive BC (NMIBC) or muscle-invasive BC (MIBC). Because the recurrence and mortality rates of BC are high, suitable biomarkers for early detection, evaluation of prognosis, and surveillance of drug responses are needed. Urinary markers simplify surveillance schedules and improve early detection of tumors, especially in NMIBC. Various markers have been identified at DNA, RNA, and protein levels with different sensitivities and specificities. Several biomarkers show a higher sensitivity than urinary cytology, but they are not accurate enough to replace it...
November 29, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27866291/japanese-contribution-to-the-field-of-sentinel-lymph-node-biopsy-for-breast-cancer-patients-introduction-to-invited-articles
#4
REVIEW
Shinzaburo Noguchi
No abstract text is available yet for this article.
November 19, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27864624/sentinel-lymph-node-biopsy-using-indocyanine-green-fluorescence-in-early-stage-breast-cancer-a-meta-analysis
#5
REVIEW
Tomoharu Sugie, Takafumi Ikeda, Atsushi Kawaguchi, Akira Shimizu, Masakazu Toi
Sentinel lymph node (SLN) biopsy using indocyanine green (ICG) fluorescence is safe and has a high detection rate for SLNs. However, the results of this novel technique are heterogeneous. The objective of this meta-analysis was to evaluate the diagnostic performance of the ICG fluorescence method compared with the standard radioisotope (RI) method. All eligible studies were identified from 2005 through 2015. A proportion meta-analysis was performed using a fixed effects and/or random effects model based on the study heterogeneity...
November 19, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27864623/simplified-hcc-art-score-for-highly-sensitive-detection-of-small-sized-and-early-stage-hepatocellular-carcinoma-in-the-widely-used-okuda-clip-and-bclc-staging-systems
#6
Abdelfattah M Attallah, Mohamed M Omran, Ahmed A Attallah, Mohamed A Abdelrazek, Khaled Farid, Ibrahim El-Dosoky
BACKGROUND: Small-sized HCC can be effectively cured by surgery with good clinical outcomes. A highly sensitive HCC α-fetoprotein routine test (HCC-ART) for HCC diagnosis as well as a simplied form of the HCC-ART were reported in the British Journal of Cancer. Here, we verified and studied the applicability of the HCC-ART to the detection of early-stage HCC. METHODS: 341 cirrhotic patients and 318 HCC patients were included in this study. For each, the HCC-ART score was calculated, and then the sensitivity, specificity, and results of an ROC curve analysis were compared between the HCC-ART and AFP when these biomarkers were used to detect small-sized HCC...
November 18, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27858183/acute-and-late-toxicities-of-pirarubicin-in-the-treatment-of-childhood-acute-lymphoblastic-leukemia-results-from-a-clinical-trial-by-the-japan-association-of-childhood-leukemia-study
#7
Hiroki Hori, Tooru Kudoh, Shinichiro Nishimura, Megumi Oda, Makoto Yoshida, Junichi Hara, Akio Tawa, Ikuya Usami, Akihiko Tanizawa, Keiko Yumura-Yagi, Koji Kato, Ryoji Kobayashi, Yoshihiro Komada, Keitaro Matsuo, Keizo Horibe
BACKGROUND: Anthracyclines are used to treat childhood acute lymphoblastic leukemia (ALL). Even when administered at low doses, these agents are reported to cause progressive cardiac dysfunction. We conducted a clinical trial comparing the toxicities of two anthracyclines, pirarubicin (THP) and daunorubicin (DNR), in the treatment of childhood ALL. The results from our study that relate to acute and late toxicities are reported here. METHODS: 276 children with B-ALL were enrolled in the trial from April 1997 to March 2002 and were randomly assigned to receive a regimen including either THP (25 mg/m(2) × 11) or DNR (30 mg/m(2) × 11)...
November 17, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27832387/incidence-of-hypophosphatemia-in-advanced-cancer-patients-a-recent-report-from-a-single-institution
#8
Taichi Yoshida, Daiki Taguchi, Koji Fukuda, Kazuhiro Shimazu, Masahiro Inoue, Katsunori Murata, Hiroyuki Shibata
BACKGROUND: Recent approval of molecular-targeted agents has contributed to improving the therapeutic outcomes of advanced cancer patients. However, they result in unusual adverse events that rarely occur with cytotoxic agents, such as hypertension, hypomagnesemia, and an acne-like rash. Although hypophosphatemia can be induced by various agents, some kinds of molecular-targeted agents are known to induce it. In addition, cancer survivors may be at a risk of hypophosphatemia. METHODS: One hundred and seventy patients, who visited the Department of Clinical Oncology at Akita University from 1 April 2014 to 31 August 2016 were enrolled in this study after providing informed consent...
November 10, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27832386/association-between-ugt1a1-28-28-genotype-and-lung-cancer-in-the-japanese-population
#9
Yoshitaka Nishikawa, Masashi Kanai, Maiko Narahara, Akiko Tamon, J B Brown, Kei Taneishi, Masahiko Nakatsui, Kazuya Okamoto, Yu Uneno, Daisuke Yamaguchi, Teruko Tomono, Yukiko Mori, Shigemi Matsumoto, Yasushi Okuno, Manabu Muto
BACKGROUND: Lung cancer is the leading cause of cancer death and is closely linked to tobacco smoking. Genetic polymorphisms in genes that encode enzymes involved in metabolizing tobacco carcinogens could affect an individual's risk for lung cancer. While polymorphism of UDP-glucuronosyltransferase1A1 (UGT1A1) is involved in detoxification of benzo(a)pyrene-7,8-dihydrodiol(-), a major tobacco carcinogen, the association between UGT1A1 genotype and lung cancer has not been examined. METHODS: We retrieved the clinical data of 5,285 patients who underwent systemic chemotherapy at Kyoto University Hospital...
November 10, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27826659/fractionated-stereotactic-radiotherapy-for-metastatic-brain-tumors-that-recurred-after-gamma-knife-radiosurgery-results-in-acceptable-toxicity-and-favorable-local-control
#10
Akifumi Miyakawa, Yuta Shibamoto, Shinya Takemoto, Toru Serizawa, Shinya Otsuka, Tatsuo Hirai
BACKGROUND: To treat local recurrence of brain metastases after gamma knife radiosurgery (GKS), we have used fractionated stereotactic radiotherapy (SRT). The purpose of this study was to evaluate the efficacy and toxicity of SRT in these patients. METHODS: Fifty locally recurrent metastatic brain tumors in 47 patients were treated with SRT. The median prescribed dose of GKS was 20 Gy at the periphery. The median interval between the GKS (the last session in cases in which multiple GKS procedures were performed) and recurrence was 7...
November 8, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27816990/combined-antitumor-effect-of-%C3%AE-secretase-inhibitor-and-abt-737-in-notch-expressing-non-small-cell-lung-cancer
#11
Jun Sakakibara-Konishi, Yasuyuki Ikezawa, Satoshi Oizumi, Junko Kikuchi, Eiki Kikuchi, Hidenori Mizugaki, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Masaharu Nishimura
BACKGROUND: Inhibition of Notch by γ-secretase inhibitor (GSI) has been shown to have an antitumor effect in Notch-expressing non-small cell lung cancer (NSCLC) and to induce apoptosis through modulation of Bcl-2 family proteins. In particular, Bim, a BH3-only member of the Bcl-2 family of proteins, has an important role in the induction of apoptosis in NSCLC when cells are treated with GSI. ABT-737, a BH3-only mimetic, targets the pro-survival Bcl-2 family and also induces apoptosis...
November 5, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27804040/oncologic-and-obstetric-outcomes-and-complications-during-pregnancy-after-fertility-sparing-abdominal-trachelectomy-for-cervical-cancer-a-retrospective-review
#12
Kaoru Okugawa, Hiroaki Kobayashi, Kenzo Sonoda, Eisuke Kaneki, Yoshiaki Kawano, Nobuhiro Hidaka, Katsuko Egashira, Yasuyuki Fujita, Hideaki Yahata, Kiyoko Kato
BACKGROUND: Trachelectomy was developed as a fertility-sparing surgery for early-stage cervical cancer in patients of childbearing age. The purpose of this study is to evaluate oncologic and obstetric outcomes and complications after abdominal trachelectomy. METHODS: We began to perform abdominal trachelectomy in 2005. Our institutional review board approved this clinical study, and fully informed consent was obtained from each patient. The medical records of patients who underwent trachelectomy were retrospectively reviewed...
November 1, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27787627/status-of-oncologic-specialties-global-survey-of-physicians-treating-cancer
#13
Takefumi Komiya, Christine B Mackay, Prabhakar Chalise
BACKGROUND: In the United States, medical oncologists play a central role in the management of systemic therapy for cancer patients. Medical oncology as a specialty is not as established in Japan and several other European nations according to recent surveys, and little is known about this specialty in developing nations. We aimed to identify global differences in the roles of physicians treating cancer; specifically, how the management of advanced disease differs among nations. METHODS: In March 2016, a self-administered internet survey was conducted with degreed physicians who prescribed systemic agents for adult cancer treatment within the past 5 years...
October 27, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27783239/risk-scores-as-useful-predictors-of-perioperative-complications-in-patients-with-rectal-cancer-who-received-radical-surgery
#14
Hiroshi Miyakita, Sotaro Sadahiro, Gota Saito, Kazutake Okada, Akira Tanaka, Toshiyuki Suzuki
BACKGROUND: Rectal cancer is associated with a higher rate of surgical complications. The ability to predict the risk of complications before treatment would facilitate the design of personalized treatment strategies optimally suited for each patient. METHODS: We retrospectively studied 260 patients with rectal cancer who underwent radical surgery to examine the relations between complications and 5 types of risk scores. RESULTS: Complications developed in 56 patients (21...
October 25, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27778118/a-panel-of-autoantibodies-as-potential-early-diagnostic-serum-biomarkers-in-patients-with-breast-cancer
#15
Ying Liu, Ying Liao, Linlin Xiang, Kuo Jiang, Siyao Li, Mingmei Huangfu, Shilong Sun
BACKGROUND: Specific circulating autoantibodies are produced by host immune systems to respond to antigens that arise during tumorigenesis. To achieve auxiliary diagnosis, the present study was designed to test whether circulating autoantibodies against tumor-associated antigens (TAAs) were altered in early breast cancer. METHODS: A total of 102 breast cancer patients and 146 age-matched healthy volunteers were recruited to participate in this study. Autoantibody expression was tested using in-house developed enzyme-linked immunosorbent assay (ELISA) with linear peptide envelope antigens derived from TAAs...
October 24, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27778117/a-comparison-of-clinical-outcomes-between-three-dimensional-conformal-radiotherapy-and-intensity-modulated-radiotherapy-for-prostate-cancer
#16
Takuya Shimizuguchi, Keiji Nihei, Tomoyuki Okano, Yumiko Machitori, Kei Ito, Katsuyuki Karasawa
BACKGROUND: Intensity-modulated radiation therapy (IMRT) reduces the dose delivered to organs at risk. However, there have been few direct comparisons of IMRT with conventional three-dimensional conformal radiotherapy (3DCRT). The aim of this study was to evaluate the clinical benefit of IMRT in terms of toxicity and biochemical control. METHODS: The medical records of 203 consecutive patients with localized to non-metastatic (stage T1a-T3bN0M0) prostate cancer between 2007 and 2011 were retrospectively reviewed...
October 24, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27771776/multidisciplinary-evaluation-at-baseline-and-during-treatment-improves-the-rate-of-compliance-and-efficacy-of-deferasirox-in-elderly-myelodysplastic-patients
#17
Lisette Del Corso, Lucia Biale, Emanuele Luigi Parodi, Rodolfo Russo, Rosa Filiberti, Eleonora Arboscello
BACKGROUND: Deferasirox (DFX) is used to reduce iron levels in patients with myelodysplastic syndrome (MDS) who develop iron overload after chronic red blood cell infusions. However, DFX can be associated with renal and gastrointestinal toxicities, which may cause treatment interruption or discontinuation. This study aimed to determine the effectiveness and safety of DFX in patients with MDS. METHODS: This multicenter, retrospective, observational study was conducted at two hospitals in Italy...
October 22, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27752787/multi-institutional-phase-ii-study-on-the-feasibility-of-liver-resection-following-preoperative-mfolfox6-therapy-for-resectable-liver-metastases-from-colorectal-cancers
#18
Satoshi Nagayama, Suguru Hasegawa, Koya Hida, Kenji Kawada, Etsuro Hatano, Kojiro Nakamura, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Takashi Matsuo, Masazumi Zaima, Akiyoshi Kanazawa, Hiroaki Terajima, Masaharu Tada, Yukihito Adachi, Ryuta Nishitai, Dai Manaka, Tsunehiro Yoshimura, Koji Doi, Takahiro Horimatsu, Akira Mitsuyoshi, Kenichi Yoshimura, Miyuki Niimi, Shigemi Matsumoto, Yoshiharu Sakai, Shinji Uemoto
BACKGROUND: Although liver resection combined with preoperative chemotherapy is expected to improve outcomes of patients with resectable colorectal liver metastasis (CRLM), there is as yet insufficient clinical evidence supporting the efficacy of preoperative systemic chemotherapy. The aim of this phase II study was to assess the feasibility and efficacy of preoperative FOLFOX systemic chemotherapy for patients with initially resectable CRLM. METHODS: A prospective multi-institutional phase II study was conducted to evaluate the feasibility and efficacy of preoperative chemotherapy for resectable CRLM (ClinicalTrials...
October 17, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27747456/biphasic-decline-in-renal-function-after-radical-cystectomy-with-urinary-diversion
#19
Katsuhiro Makino, Tohru Nakagawa, Atsushi Kanatani, Taketo Kawai, Satoru Taguchi, Masafumi Otsuka, Akihiko Matsumoto, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yukio Homma
BACKGROUND: We evaluated short- and long-term renal function in patients after radical cystectomy with urinary diversion and identified risk factors for the deterioration of renal function. METHODS: This retrospective study comprised 91 patients who underwent radical cystectomy and urinary diversion for bladder cancer and survived ≥3 years after surgery. The estimated glomerular filtration rate (eGFR) was calculated, and longitudinal changes of eGFR were assessed...
October 17, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27747455/erratum-to-final-overall-survival-in-jo22903-a-phase-ii-open-label-study-of-first-line-erlotinib-for-japanese-patients-with-egfr-mutation-positive-non-small-cell-lung-cancer
#20
Noboru Yamamoto, Koichi Goto, Makoto Nishio, Kenichi Chikamori, Toyoaki Hida, Makoto Maemondo, Nobuyuki Katakami, Toshiyuki Kozuki, Hiroshige Yoshioka, Takashi Seto, Kosei Tajima, Tomohide Tamura
No abstract text is available yet for this article.
October 17, 2016: International Journal of Clinical Oncology
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