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International Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/29159773/japan-society-of-gynecologic-oncology-guidelines-2015-for-the-treatment-of-vulvar-cancer-and-vaginal-cancer
#1
Toshiaki Saito, Tsutomu Tabata, Hitoshi Ikushima, Hiroyuki Yanai, Hironori Tashiro, Hitoshi Niikura, Takeo Minaguchi, Toshinari Muramatsu, Tsukasa Baba, Wataru Yamagami, Kazuya Ariyoshi, Kimio Ushijima, Mikio Mikami, Satoru Nagase, Masanori Kaneuchi, Nobuo Yaegashi, Yasuhiro Udagawa, Hidetaka Katabuchi
BACKGROUND: Vulvar cancer and vaginal cancer are relatively rare tumors, and there had been no established treatment principles or guidelines to treat these rare tumors in Japan. The first version of the Japan Society of Gynecologic Oncology (JSGO) guidelines for the treatment of vulvar cancer and vaginal cancer was published in 2015 in Japanese. OBJECTIVE: The JSGO committee decided to publish the English version of the JSGO guidelines worldwide, and hope it will be a useful guide to physicians in a similar situation as in Japan...
November 20, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29151227/significance-of-prostate-specific-antigen-kinetics-after-three-dimensional-conformal-radiotherapy-with-androgen-deprivation-therapy-in-patients-with-localized-prostate-cancer
#2
Wataru Fukuokaya, Sangji Kim, Takao Natsuyama, Kanako Matsuzaki, Homare Shiomi, Hiroki Kitoh, Nobuko Utsumi, Hiromasa Kurosaki, Masafumi Inoue, Koichiro Akakura
BACKGROUND: To evaluate the relationship between biochemical recurrence and post-radiation prostate-specific antigen (PSA) kinetics in patients with localized prostate cancer treated by radiotherapy with various durations of androgen deprivation therapy (ADT). METHODS: We reviewed our single-institution, retrospectively maintained data of 144 patients with T1c-T3N0M0 prostate cancer who underwent three-dimensional conformal radiotherapy (3D-CRT) between December 2005 and December 2015 and 113 patients were fulfilled the inclusion criteria...
November 18, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29143144/carcinosarcoma-of-the-ovary-compared-to-ovarian-high-grade-serous-carcinoma-impact-of-optimal-cytoreduction-and-standard-adjuvant-treatment
#3
Ibrahim Yalcin, Mehmet Mutlu Meydanli, Ahmet Taner Turan, Salih Taskin, Mustafa Erkan Sari, Tayfun Gungor, Ozgur Akbayir, Ali Ayhan
OBJECTIVE: The purpose of this retrospective study was to compare the prognoses of women with ovarian carcinosarcoma (OCS) who had optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy to those of women with ovarian high-grade serous carcinoma (HGSC) treated in the same manner. METHODS: A multicenter, retrospective department database review was performed to identify patients with OCS at eight gynecologic oncology centers in Turkey...
November 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29138948/correction-to-s-1-and-irinotecan-plus-bevacizumab-as-second-line-chemotherapy-for-patients-with-oxaliplatin-refractory-metastatic-colorectal-cancer-a-multicenter-phase-ii-study-in-japan-kscc1102
#4
Yuji Miyamoto, Akihito Tsuji, Hiroaki Tanioka, Soichiro Maekawa, Hirofumi Kawanaka, Masaki Kitazono, Eiji Oki, Yasunori Emi, Hidetsugu Murakami, Yutaka Ogata, Hiroshi Saeki, Mototsugu Shimokawa, Shoji Natsugoe, Yoshito Akagi, Hideo Baba, Yoshihiko Maehara
In the original publication, in Abstract, the sentence that reads as, "Oral S-1 at a dose of 80 mg/m(2) was…………. drug-free interval" should read as, "Oral S-1 at a dose of 40 mg/m(2) was administered twice daily for 2 weeks, followed by a 1-week drug-free interval.
November 14, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29134363/further-augmentation-of-molecular-responses-with-dasatinib-therapy-in-chronic-myeloid-leukemia-patients-who-gained-major-molecular-response-under-imatinib
#5
LETTER
Ahmet Emre Eskazan
No abstract text is available yet for this article.
November 13, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29134362/selecting-patients-for-hyperthermia-combined-with-preoperative-chemoradiotherapy-for-locally-advanced-rectal-cancer
#6
Sang-Won Kim, Ji Woon Yea, Jae Hwang Kim, Mi Jin Gu, Min Kyu Kang
BACKGROUND: This study investigated the role of hyperthermia combined with preoperative concurrent chemoradiotherapy (CCRT) for locally advanced rectal cancer (LARC) according to hypoxic marker expression. METHODS: One hundred and nine LARC patients with tissue blocks available for immunohistochemical assessment of carbonic anhydrase 9 (CA9) expression were reviewed. CA9 expression was considered positive when the staining percentage of tumor cells was >25% (n = 31)...
November 13, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29127531/impact-of-a-robotic-surgical-system-on-treatment-choice-for-men-with-clinically-organ-confined-prostate-cancer
#7
Takashi Kobayashi, Kent Kanao, Motoo Araki, Naoki Terada, Yasuyuki Kobayashi, Atsuro Sawada, Takahiro Inoue, Shin Ebara, Toyohiko Watanabe, Tomomi Kamba, Makoto Sumitomo, Yasutomo Nasu, Osamu Ogawa
BACKGROUND: Introducing a new surgical technology may affect behaviors and attitudes of patients and surgeons about clinical practice. Robot-assisted laparoscopic radical prostatectomy (RALP) was approved in 2012 in Japan. We investigated whether the introduction of this system affected the treatment of organ-confined prostate cancer (PCa) and the use of radical prostatectomy (RP). METHODS: We conducted a retrospective multicenter study on 718 patients with clinically determined organ-confined PCa treated at one of three Japanese academic institutions in 2011 (n = 338) or 2013 (n = 380)...
November 11, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29110101/histological-transformation-after-acquired-resistance-to-epidermal-growth-factor-tyrosine-kinase-inhibitors
#8
REVIEW
Yi Shao, Dian-Sheng Zhong
Non-small-cell lung cancer patients with sensitive epidermal growth factor receptor mutations generally respond well to tyrosine kinase inhibitors (TKIs). However, acquired resistance will eventually develop place after 8-16 months. Several mechanisms contribute to the resistance including T790M mutation, c-Met amplification, epithelial mesenchymal transformation and PIK3CA mutation; however, histological transformation is a rare mechanism. The patterns and mechanisms underlying histological transformation need to be explored...
November 7, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29103151/monitoring-the-estimated-glomerular-filtration-rate-egfr-in-patients-with-small-cell-lung-cancer-during-chemotherapy-equations-based-on-serum-creatinine-or-cystatin-c
#9
Xue Tian, Xinxing Zhang, Min Yu, You Lu, Zhenyu Ding, Meijuan Huang, Feng Peng, Li Ren, Jin Wang, Yongsheng Wang, Yong Xu, Jiang Zhu, Lin Zhou, Xiaojuan Zhou, Min Deng, Xin Tang, Youling Gong
BACKGROUND: This study compared the differences between the estimated glomerular filtration rate (eGFR) calculated by several equations based on serum creatinine (Scr) and cystatin C (CysC) concentrations for monitoring renal function in patients with small-cell lung cancer (SCLC) during chemotherapy. METHODS: Seventy-one patients with SCLC were retrospectively analyzed. The eGFR before and after each chemotherapy cycle was calculated by the following equations: the chronic kidney disease epidemiology collaboration (CKD-EPI) equation, the modification of diet in renal disease (MDRD) equation, the Cockcroft-Gault (CG) equation, and five CysC-based equations...
November 4, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29101499/combined-detection-of-twist1-snail1-and-squamous-cell-carcinoma-antigen-for-the-prognostic-evaluation-of-invasion-and-metastasis-in-cervical-squamous-cell-carcinoma
#10
Huilun Yang, Haiyang Hu, Yanling Gou, Yuhong Hu, Hui Li, Hongwei Zhao, Beidi Wang, Peiling Li, Zongfeng Zhang
BACKGROUND: Cervical cancer is one of the most common malignant tumours of the female reproductive system, ranking second only to breast cancer in morbidity worldwide. Essential features of the progression of cervical cancer are invasion and metastasis, which are closely related to disease prognosis and mortality rate. At the present time there is no effective method to evaluate cancer invasion and metastasis before surgery. Here we report our study on molecular changes in biopsy tissue for the prognostic evaluation of cancer invasion and metastasis...
November 3, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29098520/acute-toxicity-of-image-guided-hypofractionated-proton-therapy-for-localized-prostate-cancer
#11
Koichiro Nakajima, Hiromitsu Iwata, Hiroyuki Ogino, Yukiko Hattori, Shingo Hashimoto, Mikiko Nakanishi, Toshiyuki Toshito, Yukihiro Umemoto, Shoichiro Iwatsuki, Yuta Shibamoto, Jun-Etsu Mizoe
BACKGROUND: Hypofractionated proton therapy (HFPT) is expected to become an effective treatment approach for localized prostate cancer (PCa). The purpose of this study was to evaluate differences in acute toxicity among patients with localized PCa treated with either conventional fractionated proton therapy (CFPT) or HFPT. METHODS: A total of 526 eligible patients treated with proton therapy between February 2013 and May 2016 in three phase II trials were analyzed...
November 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29098519/significance-of-sarcopenia-as-a-prognostic-factor-for-metastatic-urothelial-carcinoma-patients-treated-with-systemic-chemotherapy
#12
Hideyuki Abe, Kohei Takei, Toshitaka Uematsu, Yuumi Tokura, Issei Suzuki, Kazumasa Sakamoto, Daisaku Nishihara, Yoshiyuki Yamaguchi, Tomoya Mizuno, Akinori Nukui, Minoru Kobayashi, Takao Kamai
BACKGROUND: Recently, numerous studies have reported an association between sarcopenia and poor outcomes in various kinds of malignancies. We investigated whether sarcopenia predicts the survival of patients with metastatic urothelial carcinoma who underwent systemic chemotherapy. METHODS: We reviewed 87 metastatic urothelial carcinoma patients who underwent chemotherapy (gemcitabine plus cisplatin or gemcitabine plus carboplatin for cisplatin-unfit patients) between 2007 and 2015...
November 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29098518/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-can-eliminate-systemic-lymphadenectomy-for-patients-with-early-stage-endometrial-cancer
#13
Tomohito Tanaka, Yoshito Terai, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
BACKGROUND: The examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer. STUDY DESIGN: Two hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid ((99m)Tc), indigo carmine and indocyanine green...
November 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29086877/neutrophil-to-lymphocyte-ratio-after-pazopanib-treatment-predicts-response-in-patients-with-advanced-soft-tissue-sarcoma
#14
Hiroshi Kobayashi, Tomotake Okuma, Hiroyuki Oka, Toshihide Hirai, Takahiro Ohki, Masachika Ikegami, Ryoko Sawada, Yusuke Shinoda, Toru Akiyama, Kenji Sato, Satoshi Abe, Hirotaka Kawano, Takahiro Goto, Sakae Tanaka
BACKGROUND: Pazopanib is a multi-tyrosine kinase inhibitor that is used to treat advanced soft-tissue sarcoma, and its efficacy has been confirmed in several clinical trials, although no clinically useful biomarkers have been identified. In other cancers, the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the lymphocyte-to-monocyte ratio (LMR) are associated with chemotherapy response and prognosis. Therefore, we aimed to evaluate the associations of pazopanib response with NLR, PLR, and LMR among patients with advanced soft-tissue sarcoma...
October 31, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29086206/radiotherapy-for-vaginal-cancer-a-multi-institutional-survey-study-of-the-japanese-radiation-oncology-study-group
#15
Hitoshi Ikushima, Masaru Wakatsuki, Takuro Ariga, Yuko Kaneyasu, Sunao Tokumaru, Fumiaki Isohashi, Noriko Ii, Takashi Uno, Tatsuya Ohno, Kokichi Arisawa, Takafumi Toita
PURPOSE: Our aim was to assess the patterns of practice and treatment outcomes of definitive radiotherapy (RT) for vaginal cancer in Japan. MATERIALS AND METHODS: RT methods and outcomes of patients with vaginal cancer treated with definitive RT or chemoradiotherapy at 10 institutes of the Japanese Radiation Oncology Study Group between January 2000 and March 2010 were retrospectively evaluated. RESULTS: A total of 90 patients were enrolled in the study...
October 30, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29063984/esophageal-squamous-cell-neoplasia-is-an-independent-negative-prognostic-factor-for-head-and-neck-cancer-patients
#16
Yasuhiko Hamada, Toshiro Mizuno, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Reiko Yamada, Hiroyuki Inoue, Yoshiyuki Takei, Naoyuki Katayama
BACKGROUND: Patients with head and neck cancer (HNC) have a high incidence of esophageal squamous cell neoplasms (ESCN). ESCN also has a negative impact on the survival of HNC patients. However, recent endoscopic advances enable the early detection of ESCN, and novel treatments may lead to improving survival rates for HNC patients with ESCN. METHODS: HNC patients who underwent magnifying esophagogastroduodenoscopy (EGDS) from 2005 to 2012 were included in this study (n = 226)...
October 24, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29063983/retrospective-analysis-of-first-line-treatment-for-follicular-lymphoma-based-on-outcomes-and-medical-economics
#17
Manaka Muneishi, Ayaka Nakamura, Katsumi Tachibana, Junko Suemitsu, Shinji Hasebe, Kazuto Takeuchi, Yoshihiro Yakushijin
BACKGROUND: Follicular lymphoma (FL) is the most common type of non-Hodgkin lymphoma (NHL), with indolent progression. Several treatment options are selected, based not only on disease status, quality of life (QOL), and age of patient, but also on recent increasing medical costs. We retrospectively analysed the first-line treatment of FL with regard to treatment outcomes and medical economics, and discuss the appropriate strategies for FL. METHODS: Data on a total of 69 newly-diagnosed patients with FL was retrospectively collected from 2001 to 2015...
October 24, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29039073/a-double-blind-randomized-phase-ii-dose-finding-study-of-olanzapine-10%C3%A2-mg-or-5%C3%A2-mg-for-the-prophylaxis-of-emesis-induced-by-highly-emetogenic-cisplatin-based-chemotherapy
#18
Takako Yanai, Satoru Iwasa, Hironobu Hashimoto, Fumiyoshi Ohyanagi, Tomomi Takiguchi, Koji Takeda, Masahiko Nakao, Hiroshi Sakai, Toshiaki Nakayama, Koichi Minato, Takahiro Arai, Kenichi Suzuki, Yasuhiro Shimada, Kengo Nagashima, Hiroyuki Terakado, Noboru Yamamoto
PURPOSE: The aim of this phase II study was to evaluate the efficacy and safety of two doses (10 and 5 mg) of olanzapine in combination with standard antiemetic treatment (aprepitant, palonosetron, and dexamethasone) for patients receiving highly emetogenic chemotherapy (HEC). METHODS: A multi-institutional, double-blind, randomized phase II, dose-finding study of olanzapine was performed in patients with a malignant solid tumor who were receiving HEC with cisplatin (≥ 50 mg/m(2))...
October 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29039072/first-line-bolus-5-fluorouracil-plus-leucovorin-for-peritoneally-disseminated-gastric-cancer-with-massive-ascites-or-inadequate-oral-intake
#19
Hiroki Hara, Shigenori Kadowaki, Masako Asayama, Akira Ooki, Toko Yamada, Takako Yoshii, Kensei Yamaguchi
BACKGROUND: There are few chemotherapeutic options for advanced gastric cancer with severe disseminated peritoneal metastases, which are usually accompanied by ascites. Bolus 5-fluorouracil (5-FU) plus leucovorin therapy has been widely used against gastrointestinal malignancies, with resulting mild toxicities. METHODS: We retrospectively analyzed the efficacy and safety of first-line chemotherapy with bolus 5-FU plus l-leucovorin in 30 advanced gastric cancer patients who had massive ascites and/or inadequate oral intake...
October 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28988295/associations-between-clinical-data-and-computed-tomography-features-in-patients-with-epidermal-growth-factor-receptor-mutations-in-lung-adenocarcinoma
#20
Yiyuan Cao, Haibo Xu, Meiyan Liao, Yanjuan Qu, Liying Xu, Dongyong Zhu, Bicheng Wang, Sufang Tian
BACKGROUND: To analyse the differences in computed tomography (CT) features between patients with lung adenocarcinoma who have epidermal growth factor receptor (EGFR) mutations and those who have wild-type EGFR. METHODS: Patients with lung adenocarcinoma (n = 156) were enrolled from October 2013 to March 2016, including 56 patients with wild-type EGFR and 100 patients with EGFR mutations. Two independent radiologists evaluated patient characteristics and imaging features...
October 7, 2017: International Journal of Clinical Oncology
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