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International Journal of Clinical Oncology

Rong Wang, Hai-Mei Qin, Li Qin, Jing-Xi Wei, Yu-Xia Wei, Jun-Li Wang
BACKGROUND: Emerging evidences were accumulated to support the view that GRP78 might be associated with multiple types of cancer. Given these, the aim of this study is to investigate the relationship between single nucleotide polymorphisms (SNPs) of GRP78 gene promoter and nasopharyngeal carcinoma (NPC). METHODS: Three SNPs (rs3216733, rs17840761 and rs17840762) in GRR78 promoter were estimated in 422 NPC patients and 452 controls. Genotyping was performed using SNaPshot SNP...
November 9, 2018: International Journal of Clinical Oncology
Juan Liu, Xianhui Ning, Xicai Sun, Hanyu Lu, Yurong Gu, Dehui Wang
BACKGROUND: Skull base osteoradionecrosis is a devastating post-irradiation complication in nasopharyngeal carcinoma patients. We conducted a retrospective analysis to assess the long-term survival and prognostic factors of patients with skull base osteoradionecrosis treated with endoscopic sequestrectomy. METHODS: We enrolled 59 nasopharyngeal carcinoma patients with skull base osteoradionecrosis who underwent endoscopic nasopharyngectomy. The clinical characteristics and outcome at the last follow-up visit were collected...
November 9, 2018: International Journal of Clinical Oncology
Toshiaki Wada, Kenji Kawada, Nobuaki Hoshino, Susumu Inamoto, Mami Yoshitomi, Koya Hida, Yoshiharu Sakai
BACKGROUND: It remains unclear whether indocyanine green (ICG) angiography could reduce the rate of postoperative anastomotic leakage (AL) following rectal surgery. The aim was to determine whether intraoperative ICG angiography could decrease symptomatic AL following laparoscopic low anterior resection (LAR). METHODS: This is a retrospective study of 149 patients with rectal cancer who underwent laparoscopic LAR at a single institution. Propensity score matching (PSM) was employed to compare groups with and without ICG angiography...
November 8, 2018: International Journal of Clinical Oncology
Takayuki Aoki, Yoshihide Ota, Masashi Sasaki, Ken-Ichi Aoyama, Takeshi Akiba, Yukari Shirasugi, Mariko Naito, Takeru Shiroiwa
BACKGROUND: The EuroQol 5-dimension scale (EQ-5D) is one of the most frequently used preference-based quality of life (QOL) measures for health technology assessment. The 3-level version of the EQ-5D comprises a descriptive system (the EQ-5D-3L) and a visual analog scale (EQ-VAS). It remains unclear whether this five-item scale correlates with the QOL of patients with oral cancer during the perioperative period. We sought to clarify this point in the present study. METHODS: Participants were 84 patients with oral malignancies who underwent radical treatment and completed the EQ-5D-3L and Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) at regular intervals over 3 months after treatment...
November 3, 2018: International Journal of Clinical Oncology
Norikazu Masuda, Kenichi Inoue, Rikiya Nakamura, Yoshiaki Rai, Hirofumi Mukai, Shinji Ohno, Fumikata Hara, Yuko Mori, Satoshi Hashigaki, Yasuaki Muramatsu, Takashi Nagasawa, Yoshiko Umeyama, Xin Huang, Hiroji Iwata
BACKGROUND: In the double-blind, phase 3 PALOMA-3 study, palbociclib-fulvestrant significantly prolonged progression-free survival versus placebo-fulvestrant in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC) whose disease had progressed on prior endocrine therapy. The present study evaluated the efficacy, safety, and pharmacokinetics of palbociclib plus fulvestrant in Japanese patients enrolled in PALOMA-3...
November 3, 2018: International Journal of Clinical Oncology
Shuji Hiramoto, Tomoko Tamaki, Kengo Nagashima, Tetsuo Hori, Ayako Kikuchi, Akira Yoshioka, Akira Inoue
BACKGROUND: Clinical efficacy of aggressive end-of-life (EOL) chemotherapy remains unclear. METHOD: Medical records of patients with advanced cancer between August 2011 and August 2016 were retrospectively analyzed. The primary endpoint was to identify prognostic factors at the last administration of chemotherapy. The secondary endpoint was to analyze the relationship between EOL symptoms and EOL treatment details. RESULTS: Among 300 evaluated patients, the number of patients who died within 14 and 30 days from the last administration of chemotherapy were 16 (5...
October 30, 2018: International Journal of Clinical Oncology
Shuhei Hakiri, Koji Kawaguchi, Takayuki Fukui, Shota Nakamura, Naoki Ozeki, Shunsuke Mori, Masaki Goto, Kumiko Hashimoto, Toshinari Ito, Kohei Yokoi
BACKGROUND: For thymic epithelial tumors (TETs), the National Comprehensive Cancer Network guideline has suggested that complete excision of the tumor should be performed without a preoperative biopsy when resectable. However, little evidence has been provided to support this strategy. The purpose of this study was to review our diagnostic process and to evaluate the validity of radical resection of anterior mediastinal masses (AMMs) without pathological confirmation. METHODS: A total of 254 patients underwent surgical resection for AMMs between 2004 and 2015...
October 29, 2018: International Journal of Clinical Oncology
Aristotelis Bamias, Vasilios Karavasilis, Nikolaos Gavalas, Kimon Tzannis, Epaminontas Samantas, Gerasimos Aravantinos, Angelos Koutras, Ioannis Gkerzelis, Euthymios Kostouros, Konstantinos Koutsoukos, Flora Zagouri, George Fountzilas, Meletios-Athanasios Dimopoulos
BACKGROUND: Vascular endothelial growth factor (VEGF) targeting represents the standard first-line therapy for metastatic renal-cell carcinoma (mRCC), while blocking the mammalian target of rapamycin (mTOR) is effective in relapsed disease. Since continuing blockade of VEGF may be of value, we studied the combination of bevacizumab with temsirolimus in mRCC patients relapsing after first-line treatment. METHODS: A prospective, phase II study of the combination of bevacizumab (10 mg/kg, every 2 weeks) with temsirolimus (25 mg weekly) in patients with mRCC who failed first-line anti-VEGF treatment...
October 29, 2018: International Journal of Clinical Oncology
Yoshiyuki Kobayashi, Tsutomu Tabata, Mayu Omori, Eiji Kondo, Toru Hirata, Kenta Yoshida, Masayuki Sekine, Atsuo Itakura, Takayuki Enomoto, Tomoaki Ikeda
BACKGROUND: In recent years, the incidence of malignant disease in pregnancy has been increasing, but there are few large-scale surveys of malignant disease in pregnancy in Japan. The aim of this study was to survey malignant disease occurring during pregnancy in Japan. METHODS: Malignant disease in pregnancy was defined as diagnosis or treatment for malignant disease, except in situ carcinoma during pregnancy, or within 1-year postpartum. First, a primary survey questionnaire of the incidence of malignant disease in pregnancy and the number of deliveries over the course of 2014 was sent to 510 medical centers in Japan...
October 27, 2018: International Journal of Clinical Oncology
Koji Kawai, Hiroyuki Nishiyama
Chemotherapy-induced gonadal dysfunction resulting in transient or persistent infertility depends on the type of drugs and cumulative dose, and it is an important long-term complication, especially for adolescent and young adult (AYA) cancer patients. Due to its importance, a clinical practice guideline for fertility preservation in childhood and AYA cancer patients was published by the Japan Society of Clinical Oncology (JSCO) in 2017. Although the precise mechanisms remain unclear, several studies reported that the cancer itself, not the cancer treatment, adversely affected semen quality...
October 23, 2018: International Journal of Clinical Oncology
Fan Dong, Tianyuan Xu, Xianjin Wang, Yifan Shen, Xiaohua Zhang, Shanwen Chen, Shan Zhong, Minguang Zhang, Qiang Ding
OBJECTIVES: To evaluate the survival benefits that lymph node dissection (LND) brought to clinically node-negative upper tract urothelial carcinoma (UTUC) patients. METHODS: Non-metastatic node-negative UTUC patients were identified from the Surveillance, Epidemiology and End Results database. N0 patients were naturally divided as cN0-pNx group (clinically diagnosed as N0 without LND performed) and cNx-pN0 group (pathologically diagnosed as node-negative no matter what clinical node status they have)...
October 17, 2018: International Journal of Clinical Oncology
Yutaka Negoro, Ryoichi Yano, Mari Yoshimura, Yoko Suehiro, Shinji Yamashita, Takaaki Kodawara, Kyohei Watanabe, Hitoshi Tsukamoto, Toshiaki Nakamura, Maiko Kadowaki, Miwa Morikawa, Yukihiro Umeda, Masaki Anzai, Tamotsu Ishizuka, Nobuyuki Goto
BACKGROUND: The association between UGT1A1 polymorphism and etoposide-induced toxicities is still not clear. The aim of this study was to assess the association between uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene polymorphism and severe hematologic toxicities in Japanese patients receiving etoposide plus platinum chemotherapy for small-cell lung cancer. METHODS: This retrospective analysis included patients with small-cell lung cancer who had received their first-line chemotherapy with etoposide plus cisplatin or carboplatin, between October 2008 and April 2018, at the University of Fukui Hospital...
October 17, 2018: International Journal of Clinical Oncology
Yukiharu Hiyoshi, Yuji Miyamoto, Yuki Kiyozumi, Hiroshi Sawayama, Kojiro Eto, Yohei Nagai, Masaaki Iwatsuki, Shiro Iwagami, Yoshifumi Baba, Naoya Yoshida, Koichi Kawanaka, Yasuyuki Yamashita, Hideo Baba
BACKGROUND: Radiofrequency ablation (RFA) can be a minimally invasive therapeutic option in patients with lung metastasis from colorectal caner. We aimed to elucidate the safety and survival benefit of computed tomography (CT)-guided percutaneous RFA for lung metastasis from colorectal cancer. METHODS: A total 188 lesions were ablated in 43 patients from 2005 to 2017. The clinicopathological and survival data of patients were collected retrospectively. The short- and long-term outcomes and prognostic factors were analyzed...
October 17, 2018: International Journal of Clinical Oncology
Akira Ohara, Tatsuro Furui, Chikako Shimizu, Seiichiro Ozono, Kazuhito Yamamoto, Akira Kawai, Ryohei Tatara, Akiko Higuchi, Keizo Horibe
In the original publication, Tables 4 and 5 have not been published in a readable format. The corrected clear version is given in this Correction.
October 15, 2018: International Journal of Clinical Oncology
Hiroshi Matsuura, Shigeki Arase, Yasuhide Hori
BACKGROUND: This study investigated the clinical outcomes of stent placement for malignant extrinsic ureteral obstruction (MUO) and predictive factors for stent failure. METHODS: We retrospectively analyzed clinical data for 91 patients with radiologically significant hydronephrosis due to MUO who underwent successful stent placement. In total, 132 ureters were stented for the decompression. Factors related to stent failure were analyzed with a Cox proportional hazards model...
October 8, 2018: International Journal of Clinical Oncology
Yasuhiko Ebina, Mikio Mikami, Satoru Nagase, Tsutomu Tabata, Masanori Kaneuchi, Hironori Tashiro, Masaki Mandai, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi, Nobuo Yaegashi, Yasuhiro Udagawa, Daisuke Aoki
The Japan Society of Gynecologic Oncology (JSGO) Guidelines 2017 for the Treatment of Uterine Cervical Cancer are for the purpose of providing standard treatment strategies for cervical cancer, indicating treatment methods currently considered appropriate for cervical cancer, minimizing variances in treatment methods among institutions, improving the safety of treatment and prognosis of diseases, reducing the economic and psychosomatic burden of patients by promoting performance of appropriate treatment, and enhancing mutual understanding between patients and healthcare professionals...
October 5, 2018: International Journal of Clinical Oncology
Misato Kaso, Yoshimitsu Takahashi, Takeo Nakayama
BACKGROUND: This study aimed to determine the factors related to undergoing cervical cancer screening among Japanese women of childrearing age by focusing on the presence or absence of children. METHODS: This was a cross-sectional study of a nationally representative sample based on the Comprehensive Survey of Living Conditions in Japan. Data for women aged 20-39 were selected, and those whose number of children was unknown, whose youngest child was under 2 years or of unknown age, who were either hospitalized or institutionalized, and who were pregnant were excluded...
October 1, 2018: International Journal of Clinical Oncology
Nobuaki Hoshino, Katsuhiro Murakami, Koya Hida, Takashi Sakamoto, Yoshiharu Sakai
PURPOSE: Accurate diagnosis of lateral lymph node metastasis is a major concern in rectal cancer. Metastasis is not only a poor prognostic factor, but it can also affect decisions about treatment options, such as preoperative chemoradiotherapy and lateral lymph node dissection. The purpose of this review was to assess the diagnostic performance of magnetic resonance imaging and computed tomography for lateral lymph node metastasis in rectal cancer. METHODS: A literature search was systematically performed using PubMed, Scopus, and the Cochrane Central Register of Controlled Trials...
September 26, 2018: International Journal of Clinical Oncology
Ayako Tsuboya, Ken-Ichi Fujita, Yutaro Kubota, Hiroo Ishida, Iori Taki-Takemoto, Daisuke Kamei, Shinichi Iwai, Yasutsuna Sasaki
BACKGROUND: Cholinergic syndrome is an acute adverse event frequently observed in patients administered irinotecan, and can sometimes negatively affect their quality of life. In some manifestations of the syndrome such as bradycardia, careful monitoring of patients is advised. In this study, we retrospectively investigated the risk factors associated with irinotecan-induced cholinergic syndrome in Japanese patients with cancer. METHODS: Patients who received irinotecan-based chemotherapy between April 2014 and June 2018 were examined...
September 22, 2018: International Journal of Clinical Oncology
Déborah Gavanier, Hélène Leport, Jérome Massardier, Fatima Abbas, Anne-Marie Schott, Touria Hajri, François Golfier, Pierre-Adrien Bolze
OBJECTIVE: To evaluate the survival and functional outcome of patients with brain metastasis due to gestational trophoblastic neoplasia (GTN). METHODS: A 17-year retrospective study based on case review of women with brain metastasis from GTN identified by the electronic databases held in the French Reference Centre. PRIMARY OUTCOME MEASURE: 5-year overall survival calculated with the Kaplan-Meier method. SECONDARY OUTCOME MEASURES: causes of death, prognostic factors and functional outcomes...
September 21, 2018: International Journal of Clinical Oncology
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