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Nephrology

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https://www.readbyqxmd.com/read/29227003/association-between-end-stage-diabetic-nephropathy-and-mthfr-c677t-and-a1298c-gene-polymorphisms
#1
Gnanasambandan Ramanathan, Bollimpalli Harichandana, Suresh Kannan, Ramprasad Elumalai, Solomon Paul
AIM: Methylenetetrahydrofolate reductase (MTHFR) is a regulatory enzyme of homocysteine metabolism. The C677T and A1298C polymorphism of the MTHFR gene has been reported to be associated with elevated plasma homocysteine in patients with Diabetic nephropathy. This study aimed to investigate the influence of the C677T and A1298C polymorphisms on the progression chronic kidney disease in diabetic nephropathy of south Indian population. METHODS: We genotyped 145 DN cases and 100 controls for the C677T and A1298C polymorphisms using PCR-RFLP based protocols, and all diabetic nephropathy cases divided into two groups based on CKD stages: 60 DN cases were early stage (CKD1 to CKD3) and 85 DN cases were advanced stage (CKD4 and CKD5)...
December 11, 2017: Nephrology
https://www.readbyqxmd.com/read/29219209/warfarin-use-and-the-risk-of-stroke-bleeding-and-mortality-in-older-adults-on-dialysis-with-incident-atrial-fibrillation
#2
Jingwen Tan, Sunjae Bae, Jodi B Segal, Junya Zhu, G Caleb Alexander, Dorry L Segev, Mara McAdams-DeMarco
AIM: There is conflicting evidence regarding the safety and effectiveness of warfarin for atrial fibrillation (AF) treatment among older end-stage renal disease (ESRD) patients, and differences among subgroups are unclear. METHODS: Older dialysis patients who were newly diagnosed with AF (7/2007-12/2011) were identified in the United States Renal Data System. The adjusted hazard ratios (HR) of the outcomes (any stroke, ischemic stroke, major bleeding, severe gastrointestinal bleeding, and death) by time-varying warfarin use were estimated using Cox regression accounting for the inverse probability of treatment weight...
December 8, 2017: Nephrology
https://www.readbyqxmd.com/read/29215180/direct-and-indirect-costs-incurred-by-australian-living-kidney-donors
#3
Lianne Barnieh, John Kanellis, Stephen McDonald, Jennifer Arnold, Jessica M Sontrop, Meaghan Cuerden, Scott Klarenbach, Amit X Garg, Neil Boudville
AIM: To describe the direct and indirect costs incurred by Australian living kidney donors. METHODS: We studied 55 living kidney donors from 3 centres in Perth, Australia and 1 centre in Melbourne, Australia (2010-2014); 49 donors provided information on expenses incurred during the donor evaluation period and up to 3 months after donation. We used a micro-costing approach to measure and value the units of resources consumed. Expenses were grouped as direct costs (ground and air travel, accommodation, and prescription medications) and indirect costs (lost wages and lost productivity)...
December 7, 2017: Nephrology
https://www.readbyqxmd.com/read/29206319/cost-utility-analysis-of-the-national-health-screening-program-for-chronic-kidney-disease-in-korea
#4
Dun-Sol Go, Seon-Ha Kim, Jongha Park, Dong-Ryeol Ryu, Hyeon-Jeong Lee, Min-Woo Jo
AIM: Although a national health screening program (NHSP) for chronic kidney disease (CKD) has been implemented in Korea since 2002, its cost-effectiveness has never been determined. This study aimed to estimate the cost-utility of NHSP for CKD in Korea. METHODS: A Markov decision analytic model was constructed to compare CKD screening strategies of the NHSP with no screening. We developed a model that simulated disease progression in a cohort aged 20 to 120 years or death from the societal perspective...
December 5, 2017: Nephrology
https://www.readbyqxmd.com/read/29194872/renal-function-up-to-the-5th-decade-of-life-after-nephrectomy-in-childhood-a-literature-review
#5
REVIEW
Denis A Cozzi, Silvia Ceccanti, Francesco Cozzi
The aim of present study was to find out if in children ablation of 50% of renal mass may be associated with a progressive renal damage (Brenner's hypothesis). We collected 1035 adult or adolescent survivors who underwent during childhood nephrectomy for unilateral oncological or non-oncological causes. Stratification of all survivors for age revealed that the number of subjects with blood hypertension and/or renal dysfunction (glomerular filtration rate <90 ml/min/1.73m2 ) to be significantly higher in survivors ≥30year-old in comparison with younger patients...
November 30, 2017: Nephrology
https://www.readbyqxmd.com/read/29193529/renal-ultrasound-and-doppler-parameters-as-markers-of-renal-function-and-histopathological-damage-in-children-with-ckd
#6
Happy Sawires, Doaa Salah, Rania Hachem, Wesam Ismail, Amr Salem, Osama Botros, Hadeel Seif
BACKGROUND: Doppler ultrasonography can be used to assess the progression of vascular (arterial sclerosis) and parenchymal (glomerular sclerosis and crescents) renal damage. The aim of this study was to evaluate the significance of some sonographic and Doppler parameters as non-invasive markers of glomerular filtration rate (GFR) and renal histopathological damage in children. METHODOLOGY: A cohort of 84 children were enrolled in a case-control study (42 with CKD stages 2-5 and 42 healthy children)...
November 30, 2017: Nephrology
https://www.readbyqxmd.com/read/29193511/epidemiology-of-haemodialysis-patients-and-haemodialysis-performance-in-nauru
#7
Chia-Tien Hsu, Richard Leona, Ming-Ju Wu
AIM: There is limited literature on haemodialysis in island countries in the Central Pacific. The primary aim of this study was to report on the epidemiology of haemodialysis patients and haemodialysis performance in Nauru. METHODS: We obtained registry data from the haemodialysis unit in Nauru to calculate the incidence rate, prevalence, and survival probability of haemodialysis patients in Nauru. We also reviewed medical records from January 2015 to February 2017 to evaluate the haemodialysis performance in Nauru...
November 28, 2017: Nephrology
https://www.readbyqxmd.com/read/29171677/acute-kidney-injury-with-consumption-of-raw-gall-bladder-of-indian-carp-fish-labeo-rohita-a-single-center-study-from-india
#8
Amresh Krishna, Prit Pal Singh, Harsh Vardhan, Om Kumar, Govind Prasad
AIM: This retrospective study examined the clinical presentation and outcome of all patients who presented with acute kidney injury (AKI) following consumption of uncooked fish gallbladder as folk medicine. METHODS: We reviewed all cases admitted at our institute between 1st January 1997 and 31st December 2016 following ingestion of fish gallbladder (Indian carp/Labeo rohita). RESULTS: A total 32 of patients were included, with a male: female ratio of 3:1 and mean age 44...
November 24, 2017: Nephrology
https://www.readbyqxmd.com/read/29160599/models-of-care-for-chronic-kidney-disease-a-systematic-review
#9
REVIEW
Ruairidh Nicoll, Lynn Robertson, Elliot Gemmell, Pawana Sharma, Corri Black, Angharad Marks
Chronic kidney disease (CKD) is common and presents an increasing burden to patients and health services. However, the optimal model of care for patients with CKD is unclear. We systematically reviewed the clinical effectiveness of different models of care for the management of CKD. A comprehensive search of eight databases was undertaken for articles published from 1992 to 2016. We included randomised controlled trials which assessed any model of care in the management of adults with pre-dialysis CKD, reporting renal, cardiovascular, mortality and other outcomes...
November 21, 2017: Nephrology
https://www.readbyqxmd.com/read/29131496/suboptimal-initiation-predicts-short-term-prognosis-and-vulnerability-among-very-elderly-patients-who-start-hemodialysis
#10
Atsuhiro Kanno, Masaaki Nakayama, Satoru Sanada, Mitsuhiro Sato, Toshinobu Sato, Yoshio Taguma
AIM: A recent, growing concern regarding hemodialysis in Japan is a sustained increase in the elderly population. Among very elderly people who start hemodialysis, the prognosis is considered to be poor; however, this has not been fully elucidated. This study aimed to discover the short-term prognosis and related factors in very elderly patients who commence hemodialysis. METHODS: Between January 2008 and December 2013, 122 patients aged ≥85 years at hemodialysis initiation were documented in our hospital...
November 13, 2017: Nephrology
https://www.readbyqxmd.com/read/29131451/what-we-do-and-do-not-know-about-women-and-kidney-diseases-questions-unanswered-and-answers-unquestioned-reflection-on-world-kidney-day-and-international-woman-s-day
#11
EDITORIAL
Giorgina B Piccoli, Mona Alrukhaimi, Zhi-Hong Liu, Elena Zakharova, Adeera Levin
Chronic Kidney Disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly...
November 13, 2017: Nephrology
https://www.readbyqxmd.com/read/29124867/acute-kidney-injury-in-critically-ill-surgical-patients-epidemiology-risk-factors-and-outcomes
#12
Konlawij Trongtrakul, Chaiwut Sawawiboon, Amanda Y Wang, Anusang Chitsomkasem, Ploynapas Limphunudom, Sathit Kurathong, Surasee Prommoon, Thananda Trakarnvanich, Nattachai Srisawat
AIM: Acute kidney injury (AKI) is one of the most serious complications seen in intensive care units (ICUs). However, its epidemiology, risk factors and clinical outcomes in surgical critically ill patients remains unclear. METHODS: A prospective cohort study was conducted in surgical intensive care unit (ICU) of the university hospital in Bangkok, Thailand. AKI was diagnosed according to the KDIGO 2012 criteria. RESULTS: A total of 189 of the 400 patients enrolled in our study developed AKI (47...
November 10, 2017: Nephrology
https://www.readbyqxmd.com/read/29094785/the-green-dialysis-survey-establishing-a-baseline-for-environmental-sustainability-across-dialysis-facilities-in-victoria-australia
#13
Katherine A Barraclough, Alice Gleeson, Stephen G Holt, John Wm Agar
AIM: The Green Dialysis Survey aimed to 1) establish a baseline for environmental sustainability (ES) across Victorian dialysis facilities, and 2) guide future initiatives to reduce the environmental impact of dialysis delivery. METHODS: Nurse unit managers of all Victorian public dialysis facilities received an online link to the survey, which asked 107 questions relevant to the ES of dialysis services. RESULTS: Responses were received from 71/83 dialysis facilities in Victoria (86%), representing 628/660 dialysis chairs (95%)...
November 2, 2017: Nephrology
https://www.readbyqxmd.com/read/29068550/5-aminolevulinic-acid-exerts-renoprotective-effect-via-nrf2-activation-in-murine-rhabdomyolysis-induced-acute-kidney-injury
#14
Atsushi Uchida, Kengo Kidokoro, Yuji Sogawa, Seiji Itano, Hajime Nagasu, Minoru Satoh, Tamaki Sasaki, Naoki Kashihara
AIM: Acute kidney injury (AKI) is associated with chronic kidney disease (CKD), as well as high mortality, but effective treatments for AKI are still lacking. A recent study reported the prevention of renal injury, such as ischemia-reperfusion injury (IRI), by 5-aminolevulinic acid (ALA), which induces an antioxidant effect. The current study aimed to investigate the effect of ALA in a rhabdomyolysis-induced mouse model of AKI created by intramuscular injection of 50% glycerol. METHODS: Rhabdomyolysis-induced AKI was induced by an intramuscular injection of glycerol (5 ml/kg body weight) into mice...
October 25, 2017: Nephrology
https://www.readbyqxmd.com/read/29064141/the-role-of-dietary-phosphate-restriction-in-chronic-kidney-disease
#15
Grahame J Elder, Avya Malik, Kelly Lambert
BACKGROUND AND OBJECTIVES: Patients with progressive chronic kidney disease (CKD) develop positive phosphate balance that is associated with increased cardiovascular risk and mortality. Modification of dietary phosphate is a commonly used strategy to improve outcomes but is complicated by the need for adequate dietary protein. Surprisingly, the evidence for patient-level benefits from phosphate restriction is tenuous, and the justification for using any phosphate binder for pre-dialysis patients is questionable...
October 24, 2017: Nephrology
https://www.readbyqxmd.com/read/29064128/the-association-between-change-in-serum-bicarbonate-and-change-in-thyroid-hormone-levels-in-patients-receiving-conventional-or-more-frequent-maintenance-hemodialysis
#16
Alessio Molfino, Gerald J Beck, Minwei Li, Joan C Lo, George A Kaysen
AIM: Correction of metabolic acidosis in patients with chronic kidney disease has been associated with improvement in thyroid function. We examined whether changes in bicarbonate were associated with changes in thyroid function in patients with end-stage renal disease receiving conventional or more frequent hemodialysis. METHODS: In the Frequent Hemodialysis Network Trials, the relationship between changes in serum bicarbonate, free triiodothyronine (FT3) and free thyroxine (FT4) was examined among 147 and 48 patients with endogenous thyroid function who received conventional (3x/week) or more frequent (6x/week) hemodialysis (Daily Trial) or who received conventional or more frequent nocturnal hemodialysis (Nocturnal Trial)...
October 24, 2017: Nephrology
https://www.readbyqxmd.com/read/29055055/e-cadherin-gene-polymorphisms-and-susceptibility-to-urolithiasis-in-iraqi-children
#17
HaidarAhmed Shamran, Shatha Hussein Ali, MaysaAbdulla Ali, QasimSharhan Al-Mayah, Elham Ahmed Jasim
AIM: This case/control study aimed to assess the impact of two SNPs in the promoter region of CDH1 gene (-160C>A and -347G>GA) on urinary stone formation in a sample of Iraqi children. METHODS: Forty-seven children with urolithiasisand 50 age- and gender-matched healthy controls. DNA was isolated from peripheral blood and direct sequencing was used for genotyping. RESULTS: The homozygous genotype of the SNP CHD1 -160C>A was more frequent in control than cases (18% vs 6...
October 20, 2017: Nephrology
https://www.readbyqxmd.com/read/29053201/changes-in-pulmonary-artery-systolic-pressure-and-right-ventricular-function-in-patients-with-end-stage-renal-disease-on-maintenance-dialysis
#18
Sadashiv Santosh, Cheng Chu, John Mwangi, Melin Narayan, Amy Mosman, Ravi Nayak, Marie Philipneri
BACKGROUND AND AIMS: Pulmonary hypertension is common in patients with end-stage renal disease, and portends a poor prognosis. There are little data in this population, and previous studies have not evaluated quantitative changes in hemodynamics over time while on maintenance dialysis. This study sought to estimate changes in pulmonary artery systolic pressure (PASP) and right ventricular function over time, and to predict PASP change using clinical variables routinely available at time of initial measurement, in patients on maintenance dialysis...
October 20, 2017: Nephrology
https://www.readbyqxmd.com/read/29030994/transplant-tourism-following-the-declaration-of-istanbul-poor-outcomes-and-nephrologist-dilemma
#19
Meteb M AlBugami, Fahad E AlOtaibe, Abdulnaser M AlAbadi, Khaled Hamawi, Khalid Bel'eed-Akkari
BACKGROUND: Transplant tourism (TT) violates many international laws and documents. Despite all efforts, TT seems to be increasing. The aim of this study is to review outcomes of recipients of commercially transplanted kidneys since the Declaration of Istanbul. METHODS: All recipients of kidney transplantation done abroad and then returned to our center, from September 2008 to December 2015, were included (tourists). Demographics and outcomes were collected from patients' charts...
October 14, 2017: Nephrology
https://www.readbyqxmd.com/read/29030945/adenine-induced-chronic-kidney-disease-in-rats
#20
REVIEW
Vishal Diwan, Lindsay Brown, Glenda C Gobe
Many animal models have been developed to study the causes and treatments of chronic kidney disease (CKD) in humans, an insidious disease resulting from kidney injury and characterised by persistent functional decline for more than 3 months, with or without evidence of structural deficit. The eventual outcome of CKD may be end-stage kidney disease (ESKD), where patients need dialysis or transplantation to survive. Cardiovascular disease is accelerated in patients with CKD and contributes to increased mortality, with the relationship between CKD and cardiovascular disease being bi-directional...
October 14, 2017: Nephrology
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