Read by QxMD icon Read


Gertruida van Biljon, VictorOL Karusseit
BACKGROUND: The South African Renal Registry (SARR) was re-established in 2010. The first report was produced in 2014. It revealed that only 3182 patients out of 43.6 million people who were dependent on the state for medical care, received renal replacement therapy (RRT) in 2012 (73 per million population). METHODS: From the SARR report and 2012 dataset, a cross-sectional study was performed of children under 14 years of age who received chronic dialysis, and incident renal transplants in 2012...
October 15, 2016: Nephrology
I-Kuan Wang, Chung-Ho Hsu, Chun-Hao Tsai, Shih-Sheng Chang, Cheng-Li Lin, Tzung-Hai Yen, Shih-Yi Lin, Chung-Chih Lin, Jiung-Hsiun Liu, Chiz-Tzung Chang, Fung-Chang Sung
No abstract text is available yet for this article.
October 10, 2016: Nephrology
Thomas A Mavrakanas, Allan D Sniderman, Paul E Barré, Ahsan Alam
AIM: This study aims to describe the variability of pre-dialysis troponin values in stable haemodialysis patients and compare the performance of single versus fluctuating or persistently elevated troponins in predicting a composite of mortality and cardiac arrest, myocardial infarction, or stroke. METHODS: 128 stable ambulatory chronic haemodialysis patients were enrolled. Pre-dialysis troponin I was measured for three consecutive months. The patients were followed for one year...
October 8, 2016: Nephrology
Tracey Ying, Samantha Chan, Stephen Lane, Christine Somerville
AIM: To identify risk factors for acute kidney injury following major orthopaedic surgery. METHODS: We included all patients undergoing major orthopaedic surgery at University Hospital Geelong between 2008 and 2014 in the study. Out of 2188 surgeries audited, we identified cases of acute kidney injury using the RIFLE criteria and matched those to controls 2:1 for age, sex, procedure and chronic kidney disease stage. We reviewed their records for risk factors of postoperative acute kidney injury, including medications such as gentamicin, diuretics, non-steroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use...
October 5, 2016: Nephrology
S D Roger, M Tio, H C Park, H L Choong, B Goh, T R Cushway, V Stevens, I C Macdougall
AIM: Higher dosages of erythropoiesis-stimulating agents (ESAs) have been associated with adverse effects. Intravenous iron is used to optimise ESA response and reduce ESA doses in haemodialysis patients; this meta-analysis evaluates the magnitude of this effect. METHODS: A literature search was performed using MEDLINE, Embase and the Cochrane Collaboration Central Register of Clinical Trials from inception until December 2014, to identify randomised controlled trials (RCTs) of intravenous iron and ESA, in patients undergoing haemodialysis for end-stage kidney disease...
October 3, 2016: Nephrology
Timothy M Williams, Andrea F Wise, Daniel S Layton, Sharon D Ricardo
BACKGROUND AND AIM: Kidney ischemia/reperfusion (IR) injury is characterised by tubular epithelial cell (TEC) death and an inflammatory response involving cytokine production and immune cell infiltration. In various kidney diseases, increased macrophage numbers correlate with injury severity and poor prognosis. However, macrophage plasticity enables a diverse range of functions, including wound healing, making them a key target for novel therapies. This study aimed to comprehensively characterise the changes in myeloid and epithelial cells and the production of cytokines throughout the experimental IR model of acute kidney injury to aid in the identification of targets to promote and enhance kidney regeneration and repair...
October 1, 2016: Nephrology
Priyakshi Kalita-DE Croft, Jennifer J Bedford, John P Leader, Robert J Walker
AIM: Long-term administration of lithium has been associated with the development of a chronic interstitial fibrosis in addition to nephrogenic diabetes insipidus (NDI). Earlier studies have demonstrated that amiloride, by blocking the epithelial sodium channel ENaC and thus preventing lithium uptake into the principal cells of the collecting ducts, can partially reverse lithium-induced NDI. However, there are no long-term studies examining whether or not amiloride also modifies the progressive chronic interstitial fibrosis and tubular atrophy often evident with long term lithium exposure...
September 28, 2016: Nephrology
Magdalena Jankowska, Abdul Rashid Qureshi, Peter Barany, Olof Heimburger, Peter Stenvinkel, Bengt Lindholm
AIM: Autosomal dominant polycystic kidney disease (ADPKD), a systemic disorder caused by mutation in genes encoding polycystins, has been reported to lead to metabolic derangements including new-onset diabetes mellitus after kidney transplantation. We analyzed markers of insulin resistance (IR), inflammation, nutritional status and insulin-like growth factor-1 (IGF-1) in end-stage renal disease (ESRD) patients with ADPKD and ESRD patients with other primary kidney diseases. METHODS: In a post hoc cross-sectional analysis in 254 non-diabetic CKD 5 patients starting on dialysis, glucose metabolism (insulin, IGF-1, homeostasis model assessment of IR, HOMA-IR), inflammation (high sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor), nutritional status, and bone mineral density (BMD), were assessed...
September 22, 2016: Nephrology
Jia Wang, Jian-Nan Li, Zhao Cui, Ming-Hui Zhao
BACKGROUND: Myeloperoxidase (MPO) is pathogenic in ANCA associated vasculitis. It also acts as bactericidal agent. MPO has five N-linked glycosylation sites on its heavy chains. The effect of glycosylation pattern to the functions of MPO is barely known. METHODS: We used eight glycosidases to remove different glycans on MPO separately. The chlorination activity of MPO, the binding between ceruloplasmin and MPO, and the reversing effect of MPO-ANCA to this binding were measured...
September 19, 2016: Nephrology
Lan Wu, Vivian Yawei Guo, Carlos King Ho Wong, Kenny Kung, Li Han, XinLing Wang, Yunzhi Luo
BACKGROUND: Most of the existing risk scores for identifying people with reduced estimated glomerular filtration rate (eGFR) involve laboratory-based factors, which are not convenient and cost-effective to use in large population-based screening program. We aimed at using non-invasive variables to identify subjects with reduced eGFR in a Chinese working population. METHODS: Two study populations were recruited in 2012 and 2015, respectively. The 2012 study population (n = 14,374) was randomly separated as the training dataset (n = 9,621) or the internal testing dataset (n = 4,753) at a ratio of 2:1, and the 2015 study population (n = 4,371) was used as the external testing dataset...
September 14, 2016: Nephrology
Siribha Changsirikulchai, Pornpen Sangthawan, Jirayut Janma, Nintita Sripaiboonkit, Suthee Rattanamongkolgul, Bandit Thinkamrop
AIM: To evaluate the achievement in controlling the risk factors of cardiovascular diseases (CVD) in Thai patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD). METHODS: The DMHT dataset from 2011-2012 which was the cross sectional study of the national survey in Thai patients with T2DM was analysed. RESULTS: There were 1,254 of 15,149 diabetic patients with estimated glomerular filtration rate (eGFR) less than 60 ml/min/1...
September 8, 2016: Nephrology
Rachael Walker, Roger Marshall, Kirsten Howard, Rachael L Morton, Mark R Marshall
BACKGROUND: There is little research exploring the association between clinicians' behaviours and home dialysis uptake. This paper aims to better understand the influence of clinicians on home dialysis modality recommendations and uptake. METHODS: On-line survey of all NZ renal units to determine the influence of individuals within pre-dialysis teams. We used the self-declaration scale of influence to rate the identified member's perceived influence on decision-making...
September 6, 2016: Nephrology
Elham Alehabib, Javad Jamshidi, Hamid Ghaedi, Fahimeh Askarian, Leila Mahmoudieh, Amir Hossein Johari, Hossein Darvish
No abstract text is available yet for this article.
September 5, 2016: Nephrology
Maggie Ming Yee Mok, Maggie Kam Man Ma, Desmond Yat Hin Yap, Gavin Sheung Wai Chan, Man Fai Lam, Janette Siu Yin Kwok, Lorraine Pui Yuen Kwan, Gary Chi Wang Chan, Cindy Bo Ying Choi, Sydney Chi Wai Tang, Tak Mao Chan
AIM: Accumulating literature indicates that late acute rejection (LAR) after kidney transplantation portends an unfavorable prognosis. There is no data on the incidence of LAR in Asian subjects, nor its risk factors and associated clinical outcomes. METHODS: We conducted a retrospective single-centre case-control study to investigate the incidence, risk factors and prognosis of LAR in Chinese kidney transplant recipients. Subjects with or without LAR were matched for age, gender, era of transplantation, allograft type, and maintenance immunosuppression regimen...
September 2, 2016: Nephrology
Masaaki Yanishi, Hiroyasu Tsukaguchi, Nguyen Thanh Huan, Yuya Koito, Hisanori Taniguchi, Kenji Yoshida, Takao Mishima, Motohiko Sugi, Hidefumi Kinoshita, Tadashi Matsuda
AIM: Optimizing nephron supply to recipient demand is a non-immunologic determinant of renal allograft outcome. Nephron reduction is usually caused by physical donor-recipient mismatch, but its pathologic relevance remains to be determined. METHODS: Thirty-one recipients of living donor renal transplants were divided into three subgroups: those who received transplants from the same gender (n = 6, Group 1) and those who underwent male-to-female (n = 8, Group 2) and female-to-male (n = 17, Group 3) transplants...
August 30, 2016: Nephrology
Leah Krischock, Sean E Kennedy, Andrew Hayen
AIM: Improve the understanding of outcomes and complications of dialysis in Adolescents and Young Adults (AYA) to inform decisions about dialysis modality in this patient population. METHODS: Registry data on Australian AYA aged 13 to 20 years who commenced dialysis between 1/1/2000 and 31/12/2013 were retrieved from the Australia and New Zealand Dialysis and Transplantation Registry and analysed to determine associations between demographic characteristics, dialysis modality and outcomes...
August 30, 2016: Nephrology
Sradha Kotwal, Martin Gallagher, Alan Cass, Angela Webster
AIM: Patients in rural areas experience poor access to health services. There are limited data on patterns of health service utilization in rural patients treated with renal replacement therapy (RRT). METHODS: All prevalent patients over the age of 18 and resident in New South Wales (NSW) who were receiving RRT on 01/07/2000 and incident patients who started RRT between the 01/07/2000 up until 31/07/2010 were included in the study. The Accessibility Remoteness Index of Australia was used to measure rurality, and to categorise participant postcode of residence at the time of their first use of a NSW health care facility after the start of RRT...
August 30, 2016: Nephrology
Jeng-Dau Tsai, Chang-Ching Wei, Sheng-Hui Yang, Hueng-Chuen Fan, Chih-Chuan Hsu, Min-Che Tung, Min-Ling Tsai, Ji-Nan Sheu
AIM: Tuberous sclerosis complex (TSC) presents with multisystem benign neoplasm induced by dysregulation of the mammalian target of rapamycin pathway. This study aimed to examine the effects of oral everolimus with either at 2.5 or 5.0 mg daily on the treatment of TSC-associated renal angiomyolipoma (AML). METHODS: Between July 2012 and August 2015, patients with TSC-associated renal AML were selected for everolimus therapy protocol. An oral everolimus starting dose at 2...
August 27, 2016: Nephrology
Xiaoyang Wang, Xiaoxue Zhang, Shan Lu, Dong Liu, Genyang Chen, Yanna Dou, Wenming Yuan, Shuang Ma, Yansheng Li, Jing Xiao, Zhanzheng Zhao
OBJECTIVES: This study aims to evaluate the safety of mycophenolate mofetil (MMF) and its effect on residual renal function (RRF) during peritoneal dialysis (PD). METHODS: This is a prospective, randomized study comprising 60 PD patients. The patients were assigned either to the MMF group (MMF dosage: 1-1.5 g/day in two divided doses for 6 months, followed by a dose of 0.5-0.75 g/day for another 6 months) or to the control group. The patients close monitoring for 1 year...
August 25, 2016: Nephrology
Kazuomi Yamashita, Sonoo Mizuiri, Yoshiko Nishizawa, Shigemoto Kenichiro, Shigehiro Doi, Takao Masaki
BACKGROUND/AIM: Iron deficiency stimulates fibroblast growth factor 23 (FGF23) transcription. This study aimed to determine whether oral ferrous iron (Fe(2+) ) reduces the serum FGF23 levels of iron-deficient maintenance hemodialysis (MHD) patients in the same way as oral ferric iron (Fe(3+) ). METHODS: Thirty-one MHD patients with iron deficiency were enrolled in this prospective study. Patients who had taken iron supplements during the 8 weeks before the study were excluded...
August 25, 2016: Nephrology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"