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Nephrology

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https://www.readbyqxmd.com/read/29457863/the-b-type-natriuretic-peptide-is-a-useful-biomarker-for-the-estimation-of-volume-overload-in-children-with-hypertension-in-children-on-peritoneal-dialysis
#1
Joo Hoon Lee, Young Seo Park
AIM: To evaluate the usefulness of serum B-type natriuretic peptide (BNP) as a biomarker of fluid retention in hypertensive children on peritoneal dialysis (PD). METHODS: We included hypertensive children on PD. We reviewed the changes (∆) of body weight (BWt), blood pressure (BP) and serum BNP at initial and follow-up periods. We presented data as mean±standard deviation (median, minimum - maximum). Wilcoxon signed-rank test was used to evaluate the changes in BWt, BP, and BNP...
February 19, 2018: Nephrology
https://www.readbyqxmd.com/read/29451342/deleterious-effect-of-anti-angiotensin-ii-type-1-receptor-antibodies-detected-pretransplant-on-kidney-graft-outcomes-is-both-proper-and-synergistic-with-donor-specific-anti-hla-antibodies
#2
Jorge Malheiro, Sandra Tafulo, Leonídio Dias, La Salete Martins, Isabel Fonseca, Idalina Beirão, António Castro-Henriques, António Cabrita
AIM: Both donor-specific antibodies (DSA) and anti-angiotensin II type 1 receptor antibodies (AT1R-abs) have been associated with poor graft outcomes after kidney transplantation (KT). We aimed to understand the impact of pretransplant AT1R-abs with or without concomitant DSA on KT outcomes. METHODS: Seventy-six patients transplanted in 2009 were studied. DSA (MFI>1000) and/or AT1R-abs (>10UI) were detected by solid-phase assays in pre-KT sera. Multivariable Cox regression models were used to determine independent predictors of outcomes: acute rejection (AR) and graft failure...
February 16, 2018: Nephrology
https://www.readbyqxmd.com/read/29451341/validation-of-acute-kidney-injury-according-to-the-modified-kdigo-criteria-in-infants-after-cardiac-surgery-for-congenital-heart-disease
#3
Kentaro Ueno, Shunji Seki, Naohiro Shiokawa, Tomoyuki Matsuba, Akinori Miyazono, Daisuke Hazeki, Yutaka Imoto, Yoshifumi Kawano
AIM: We aimed to validate the incidence of, risk factors for, and postoperative outcomes of acute kidney injury (AKI) according to the modified Kidney Disease Improving Global Outcomes (m-KDIGO) criteria and compare this criteria with both the pediatric Risk, Injury, Failure, Loss, End-stage disease (pRIFLE) and Acute Kidney Injury Network (AKIN) criteria in infants after cardiac surgery. METHODS: We retrospectively enrolled 145 consecutive infants who underwent open-heart surgery at Kagoshima University Hospital...
February 16, 2018: Nephrology
https://www.readbyqxmd.com/read/29437270/clinicians-attitudes-and-approaches-to-evaluating-the-potential-living-kidney-donor-recipient-relationship-an-interview-study
#4
Angelique F Ralph, Phyllis Butow, Jonathan C Craig, Jeremy R Chapman, John S Gill, John Kanellis, Allison Tong
AIM: Careful assessment of the potential donor-recipient relationship is recommended by guidelines to prevent undue coercion, and ensure realistic expectations and genuine motivations. However, relationships are complex, nuanced and value-laden, and can be challenging to evaluate in living kidney donation. We aimed to describe the attitudes and approaches of transplant clinicians towards assessing the relationship between potential living kidney donors and their recipients. METHODS: Semi-structured interviews were conducted with 54 transplant clinicians (nephrologists, surgeons, coordinators, social workers, psychiatrists and psychologists) from 32 transplant centres across nine countries including Australia, United States, Canada and New Zealand...
February 13, 2018: Nephrology
https://www.readbyqxmd.com/read/29424935/the-effect-of-extended-hours-dialysis-on-sleep-quality-in-a-randomised-trial
#5
Jin-Lan Liao, Oliver van den Broek-Best, Brendan Smyth, Daqing Hong, Kha Vo, Li Zuo, Nicholas A Gray, Christopher T Chan, Janak de Zoysa, Vlado Perkovic, Lei Jiang, Meg Jardine
BACKGROUND: Poor sleep quality is common in haemodialysis patients and associated with worse outcomes. In this pre-specified analysis, we examined the impact of extended hours haemodialysis on sleep quality. METHODS: The ACTIVE Dialysis trial randomized 200 participants to extended (≥24 hours/week) or standard (target 12-15 hours) hours haemodialysis over 12 months. Sleep quality was measured in the Kidney Disease Quality of Life Short Form 1.3 (KDQOL-SF) by overall sleep quality score (0-10, 10 = "very good") and the sleep subscale (0-100, 100 = 'best possible sleep') every three months via blinded telephone interviewer...
February 9, 2018: Nephrology
https://www.readbyqxmd.com/read/29419916/consensus-opinion-on-diagnosis-and-management-of-thrombotic-microangiopathy-in-australia-and-new-zealand
#6
REVIEW
Lucy Fox, Solomon J Cohney, Joshua Y Kausman, Jake Shortt, Peter D Hughes, Erica M Wood, Nicole M Isbel, Theo de Malmanche, Anne Durkan, Pravin Hissaria, Piers Blombery, Thomas D Barbour
Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory to look for red cell fragments on a blood film. Whilst TMA of any aetiology generally demands prompt treatment, this is especially so in thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS), where organ failure may be precipitous, irreversible and fatal...
February 8, 2018: Nephrology
https://www.readbyqxmd.com/read/29405547/abdominal-aortic-calcification-score-predicts-the-occurrence-of-coronary-artery-disease-in-middle-aged-peritoneal-dialysis-patients
#7
Hung-Chih Chen, Che-Yi Chou, Hsuan-Jen Lin, Chiu-Ching Huang, Chiz-Tzung Chang
BACKGROUND: Abdominal aortic calcification (AAC) score in dialysis patients was associated with coronary artery disease (CAD) in cross-sectional study, but the use of AAC score in the CAD occurrence prediction was not clear. We aimed to use AAC score in the estimation of CAD occurrence in middle-aged peritoneal dialysis (PD) patients. METHODS: Middle-aged (45-65 years old) PD patients were recruited and followed up until CAD occurrence, patient mortality, or PD failure...
February 5, 2018: Nephrology
https://www.readbyqxmd.com/read/29405503/review-an-australian-model-of-care-for-co-morbid-diabetes-and-chronic-kidney-disease
#8
REVIEW
Clement Lo, Edward Zimbudzi, Helena Teede, Alan Cass, Greg Fulcher, Martin Gallagher, Peter G Kerr, Stephen Jan, Greg Johnson, Tim Mathew, Kevan Polkinghorne, Grant Russell, Tim Usherwood, Rowan Walker, Sophia Zoungas
Diabetes and chronic kidney disease (CKD) are two of the most prevalent co-morbid chronic diseases in Australia. The increasing complexity of multi-morbidity, and current gaps in health-care delivery for people with co-morbid diabetes and CKD, emphasise the need for better models of care for this population. Previously, proposed published models of care for co-morbid diabetes and CKD have not been co-designed with stake-holders or formally evaluated. Particular components of health-care shown to be effective in this population are interventions that: are structured, intensive and multifaceted (treating diabetes and multiple cardiovascular risk factors); involve multiple medical disciplines; improve self-management by the patient; and upskill primary health-care...
February 5, 2018: Nephrology
https://www.readbyqxmd.com/read/29389053/a-case-control-study-of-end-of-life-treatment-preferences-and-costs-following-advance-care-planning-for-adults-with-end-stage-kidney-disease
#9
Marcus Sellars, Rachael L Morton, Josephine M Clayton, Allison Tong, Daveena Mawren, William Silvester, David Power, Ronald Ma, Karen M Detering
AIM: To examine the efficacy of advance care planning (ACP) to improve the likelihood that end-stage kidney disease (ESKD) patient's preferences will be known and adhered to at end-of-life. METHODS: A case-control study of a nurse-led ACP program in adults with ESKD from a major tertiary hospital. The primary outcome was the proportion of patients whose preferences were known (by substitute decision maker and/or clinicians) and adhered to by their treating doctors...
February 1, 2018: Nephrology
https://www.readbyqxmd.com/read/29380920/interleukin-10-1082a-g-polymorphism-is-associated-with-renal-parenchymal-damage-in-congenital-anomalies-of-the-kidney-and-urinary-tract
#10
Lyuba Dineva Miteva, Emilya Stambolova Kostadinova, Spaska Angelova Stanilova
AIM: The aim of the study was to investigate whether the functional IL10-1082A/G polymorphism exert a role in congenital anomalies of the kidney and urinary tract (CAKUT) in children. Also, the serum IL-10 and its association with genotype and renal parenchymal damage in CAKUT were explored. METHODS: In current case-control study, 134 paediatric cases of CAKUT and 382 unrelated controls were included. The genotyping of IL10-1082A/G polymorphism was performed by amplification refractory mutation system-PCR and IL-10 serum level was determined by ELISA...
January 30, 2018: Nephrology
https://www.readbyqxmd.com/read/29369449/biomarkers-for-acute-kidney-injury-in-decompensated-cirrhosis-a-prospective-study
#11
David A Jaques, Laurent Spahr, Gregory Berra, Vincent Poffet, Pierre Lescuyer, Eric Gerstel, Nicolas Garin, Pierre-Yves Martin, Belen Ponte
BACKGROUND: Acute kidney injury (AKI) is a frequent complication in cirrhotic patients. As serum creatinine is a poor marker of renal function in this population, we aimed to study the utility of several biomarkers in this context. METHODS: A prospective study was conducted in hospitalized patients with decompensated cirrhosis. Serum creatinine (SCr), Cystatin C (CystC), NGAL and urinary NGAL, KIM-1, protein, albumin and sodium were measured on three separate occasions...
January 25, 2018: Nephrology
https://www.readbyqxmd.com/read/29359889/periodontal-and-chronic-kidney-disease-association-a-systematic-review-and-meta-analysis
#12
Kostas Kapellas, Ankur Singh, Maitê Bertotti, Gustavo Nascimento, Lisa M Jamieson
AIM: Chronic kidney disease (CKD) and kidney failure is increasing globally and evidence from observational studies suggest periodontal disease may contribute to kidney functional decline. METHODS: Electronic searches of the PubMed, EMBASE, Web of Science, Scopus and Cochrane Library databases were conducted for the purposes of conducting a systematic review. Hand searching of reference lists was also performed. Meta-analysis of observational studies involving periodontal disease and chronic kidney disease in adults was performed...
January 23, 2018: Nephrology
https://www.readbyqxmd.com/read/29356227/efficacy-of-peritoneal-dialysis-in-neonates-presenting-with-hyperammonaemia-due-to-urea-cycle-defects-and-organic-acidaemia
#13
Muhittin Celik, Osman Akdeniz, Nezir Ozgun
AIM: Newborns with inborn errors of metabolism can present with hyperammonaemic coma. In this study, we evaluated the effect of peritoneal dialysis on plasma ammonium levels and on the short-term outcome in neonatal patients with urea cycle defects and organic acidaemia. METHODS: Data from infants with hyperammonaemia due to urea cycle defects or organic acidaemia treated with dialysis were collected and retrospectively analysed. The results of patient groups (group I, survived; and group II, died) were compared...
January 22, 2018: Nephrology
https://www.readbyqxmd.com/read/29345092/-known-unknowns-examining-the-burden-of-neurocognitive-impairment-in-the-end-stage-renal-failure-population
#14
REVIEW
Scott Wilson, Arup Dhar, Peter Tregaskis, Gavin Lambert, David Barton, Rowan Walker
The burden of neurocognitive impairment (NCI) in patients receiving maintenance dialysis represents a spectrum of deficits across multiple cognitive domains which are associated with hospitalisation, reduced quality-of-life, mortality and forced decision-making around dialysis withdrawal. Point prevalence data suggests that dialysis patients manifest NCI at rates 3-5 fold higher than the general population with executive function the most commonly affected cognitive domain. The unique physiology of the renal failure state and maintenance dialysis appears to drive an excess of vascular dementia subtype compared to the general population where classical Alzheimer's disease predominates...
January 18, 2018: Nephrology
https://www.readbyqxmd.com/read/29327401/daclatasvir-and-reduced-dose-sofosbuvir-an-effective-and-pangenotypic-treatment-for-hepatitis-c-in-patients-with-egfr-30-ml-min
#15
Amit Goel, Dharmendra Singh Bhadauria, Anupma Kaul, Prashant Verma, Mayank Mehrotra, Amit Gupta, Raj Kumar Sharma, Praveer Rai, Rakesh Aggarwal
BACKGROUND & AIMS: Sofosbuvir is a key agent for HCV treatment. It is not recommended for patients with chronic kidney disease (CKD) and estimated glomerular filtration rate (eGFR) <30 mL/min. We report real-life experience of treating a cohort of CKD patients with eGFR <30 mL/min using daclatasvir and half-daily dose of sofosbuvir. METHODS: Adults patients who (i) had eGFR<30 ml/min and detectable HCV RNA and (ii) were treated with interferon and ribavirin free, DAA based regimens were included...
January 12, 2018: Nephrology
https://www.readbyqxmd.com/read/29316017/a-comparison-of-graft-and-patient-outcomes-following-kidney-transplantation-in-extended-hour-and-conventional-haemodialysis-patients
#16
Emily J See, Carmel M Hawley, Yeoungjee Cho, Nigel D Toussaint, John Wm Agar, Elaine M Pascoe, Wai H Lim, Ross S Francis, Michael G Collins, David W Johnson
AIM: Differences in early graft function between kidney transplant recipients previously managed with either haemodialysis (HD) or peritoneal dialysis are well described. However, only two single-centre studies have compared graft and patient outcomes between extended hour and conventional HD patients, with conflicting results. METHODS: This study compared the outcomes of all extended hour (≥24 hours/week) and conventional HD patients transplanted in Australia and New Zealand between 2000 and 2014...
January 8, 2018: Nephrology
https://www.readbyqxmd.com/read/29314372/reduction-in-anastomotic-flow-disturbance-within-a-modified-end-to-side-arteriovenous-fistula-configuration-results-of-a-computational-flow-dynamic-model
#17
John Carroll, Ramon L Varcoe, Tracie Barber, Anne Simmons
BACKGROUND/AIMS: We sought to determine if a modification to the peri-anastomotic vein configuration during end-to-side arteriovenous fistula (AVF) creation would achieve a favorable hemodynamic environment compared with the standard acute-angle AVF. METHODS: Computational fluid dynamics (CFD) modelling of two end-to-side AVF geometries (smooth-vein-loop vs acute-angle) allowed for hemodynamic modelling. Hemodynamic fields at various stages of the pulse cycle were observed and compared across both models...
January 5, 2018: Nephrology
https://www.readbyqxmd.com/read/29292855/molecular-basis-of-complement-factor-i-deficiency-in-tunisian-atypical-hemolytic-and-uremic-syndrome-patients
#18
Hend Jlajla, Fatma Dehman, Manel Jallouli, Rania Khedher, Imen Ayadi, Yosr Zerzeri, Lilia Laadhar, Imen Sfar, Abdelmajid Mahfoudh, Yosr Gorgi, Elhem Cheour, Karim Zouaghi, Tahar Gargueh, Maryam Kallel Sellami
AIM: To characterize molecular basis of complement factor I deficiency in Tunisian atypical haemolytic and uremic syndrome patients with low factor I levels. METHODS: Six adults and 7 children were enrolled in this study. Complement factor I levels were assessed by a homemade sandwich ELISA and ranged between 12.5 and 60%. Genomic DNA was amplified by way of a polymerase chain reaction using intronic primers flanking the 13 coding exons. Sequencing of amplified products was carried by the dye terminator sequencing method...
January 2, 2018: Nephrology
https://www.readbyqxmd.com/read/29280536/screening-of-genes-involved-in-epithelial-mesenchymal-transition-and-differential-expression-of-complement-related-genes-induced-by-pax2-in-renal-tubules
#19
Xiu-Li Wang, Ling Hou, Cheng-Guang Zhao, Ying Tang, Bo Zhang, Jing-Ying Zhao, Yu-Bin Wu
AIM: To screen and verify downstream genes involved in the epithelial mesenchymal transition (EMT) induced by paired box 2 (PAX2) in NRK-52E cells. METHODS: NRK-52E cells were transfected with lentivirus carrying PAX2 gene or no-load virus respectively. Total RNA was isolated 72 hr after transfection from PAX2-overexpressing cells and control cells. Isolated RNA was then hybridized with the Rat OneArray Plus expression profile chip. The chips were examined by Agilent 0...
December 27, 2017: Nephrology
https://www.readbyqxmd.com/read/29278442/sevelamer-hydrochloride-suppresses-proliferation-of-parathyroid-cells-during-the-early-phase-of-chronic-renal-failure-in-rats
#20
Xiao Xiao, Yan Liu, Xiaoshi Zhong, Daoyuan Zhou, Xuan Xiong
AIM: We examined the effects of sevelamer on parathyroid cell proliferation and secondary hyperparathyroidism in rats following induction of early-phase early phase of chronic renal failure (CRF) by unilateral ureteral obstruction (UUO). METHODS: For 5 days, rats in the control group received normal food, rats in the sevelamer group (SH) received control food plus 5% sevelamer, and rats in the low protein group (LP) received low protein food. Five rats of each group were sacrificed at baseline (d0)...
December 26, 2017: Nephrology
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