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Wattanachai Ungjaroenwathana, Thanida Chiramongkolsiri, Thasinas Dissayabutra, Chanchai Boonla, Phisit Prapunwattana, Kriang Tungsanga, Piyaratana Tosukhowong
BACKGROUND: Urolithiasis has high recurrent rate after surgical removal within 3 years. Potassium citrate compound is used to prevent stone recurrence but it has intolerable gastrointestinal adverse effects. We conducted a phase 2 clinical study of lime power regimen (LPR), a limeade-based supplement containing potassium and citrate for 6-month period of treatment, to evaluate its effects on biochemical and clinical aspects of recurrent urolithiasis. METHODS: Seventy-four urolithiasis patients were randomly allocated to receive either LPR or placebo for 6 months in a double blinded manner...
September 18, 2018: Nephrology
Youhyun Kim, Hyeok Choi, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
OBJECTIVES: We investigated whether systemic immune-inflammation index (SII) at diagnosis can estimate the cross-sectional high activity and predict the poor outcomes in immunosuppressive drug-naïve patients with ANCA-associated vasculitis (AAV). METHODS: We retrospectively reviewed the medical records of 163 patients with AAV and obtained clinical and laboratory data. We calculated Birmingham vasculitis activity score (BVAS) as well as five factor score (FFS) (2009) at diagnosis...
September 11, 2018: Nephrology
Derek A DuBay, Zemin Su, Thomas A Morinelli, Prabhakar Baliga, Vinayak Rohan, John Bian, David Northrup, Nicole Pilch, Vinaya Rao, Titte R Srinivas, Patrick D Mauldin, David J Taber
AIM: Identifying kidney transplant patients at highest risk for graft loss prior to loss may allow for effective interventions to improve 5-year survival. METHODS: We performed a ten-year retrospective cohort study of adult kidney transplant recipients (n=1,747). We acquired data from electronic health records, United Network of Organ Sharing, social determinants of health, natural language processing data extraction, and real-time capture of dynamically evolving clinical data obtained within 1-year of transplant; from which we developed a 5-year graft survival model...
September 9, 2018: Nephrology
Yu-Ming Huang, Damin Xu, Jianyan Long, Ying Shi, Luxia Zhang, Haibo Wang, Adeera Levin, Ming-Hui Zhao
AIM: To investigate the spectrum of chronic kidney disease (CKD) in China. METHODS: We utilized a large national in-patient database covering 878 class 3 hospitals and involving 64.7 million adult patients in China from 2010 to 2015. The class 3 hospital in China are ranked as the top tier of medical system in China with at least 500 beds and the accreditation from health authorities. The specific causes of CKD were extracted from International Classification of Diseases-10 codes of discharge diagnoses...
September 9, 2018: Nephrology
Chu Lin, Danxia Zheng, Yue Wang, Song Wang
AIM: To investigate the clinicopathological features of idiopathic membranous nephropathy (IMN) in youth. METHODS: Patients with biopsy-proven IMN in Peking University Third Hospital from May 2015 to October 2017 (n=147) were enrolled in this study, in which patients were divided into youth group (≤35 years old), middle-age group (35-65 years old) and elderly group (>65 years old) accordingly. Clinical and pathological records of patients were retrospectively analyzed...
September 3, 2018: Nephrology
Baekjun Sung, Ye Su, Jifu Jiang, Patrick Mcleod, Weihua Liu, Aaron Haig, Douglas R Green, Zhu-Xu Zhang, Anthony M Jevnikar
BACKGROUND: Ischemia reperfusion injury (IRI) is associated with programmed cell death that promotes inflammation and organ dysfunction. Necroptosis is mediated by members of receptor interacting protein kinases (RIPK1/3). Inhibition of RIPK1/3 provides a pro-survival benefit in kidney IRI. Caspase-8 initiate apoptosis and contributes to IRI. We studied whether inhibiting both RIPK3 and caspase-8 would provide an additional benefit in kidney IRI. METHODS: A clamp was applied to the left kidney pedicle for 45 minutes followed by right kidney nephrectomy...
September 3, 2018: Nephrology
Maxime Touzot, Thibaud Lefebvre, Arthur Roux, Catherine Maheas, Christophe Ridel, Hervé Puy, Zoubida Karim
AIM: Relatively few hemodialysis patients (HD) remain independent of recombinant human EPO ("rHU-EPO free patients"). We investigated the role of EPO and Hepcidin, two key hormones involved in anemia. METHODS: we report a monocentric Case-control serie. Iron status, EPO and Hepcidin levels were analysed in 15 Adult HD (Age>18 years) with a stable hemoglobin level that have not received rHU-EPO for at least 6 months (=rHU-EPO free patients); and in 60 controls with a stable rHU-EPO dose and hemoglobin level...
September 3, 2018: Nephrology
Moisés Carminatti, Hélio Tedesco-Silva, Natália Maria da Silva Fernandes, Helady Sanders-Pinheiro
Kidney transplant recipients are a subset of patients with chronic kidney disease that remain at high risk for progression to dialysis and mortality. Recent advances in immunosuppression have only partially improved long-term graft and patient survival. Discovery of new immunosuppressive regimens is a slow and resource-intensive process. Hence, recognition and management of modifiable allogeneic and non-allogeneic risk factors for progression to chronic kidney disease among kidney transplant recipients is of major interest for improving long-term outcomes...
August 30, 2018: Nephrology
Matthew P Sypek, Philip A Clayton, Wai Lim, Peter Hughes, John Kanellis, Jenni Wright, Jeremy Chapman, Stephen P McDonald
BACKGROUND: A detailed analysis of waitlisting for deceased donor kidney transplantation in Australia has not previously been reported. We aimed to determine if patient characteristics associated with waitlisting identify areas of potential inequality in access to transplantation in Australia. METHODS: A competing risk time-to-event model was used to determine predictors of waitlisting for all adult incident renal replacement therapy patients in Australia between 2006-2015...
August 30, 2018: Nephrology
N Abeysekera, A Graver, L Cooley, G Kirkland, M D Jose
AIM: Examine the incidence of suspected and proven infections, the range of infections, antimicrobial use, hospital admissions in kidney transplant recipients in southern Tasmania. METHOD: An audit of the medical records of kidney transplant recipients managed by the Royal Hobart Hospital for the period 1st of January 2015 to 31st of December 2016. Data was collected on positive microbiological investigations, antimicrobial use and hospital admissions. RESULTS: Of the 151 evaluable kidney transplant recipients, there were 339 episodes of suspected infection in 95 (63%) patients with a preponderance of urinary tract infections...
August 27, 2018: Nephrology
Benjamin Anderson, Khalid Khalil, Felicity Evison, Jay Nath, Adnan Sharif
AIM: The aim of this retrospective cohort study was to investigate whether pre-operative hypoalbuminaemia (<35 g/L) is associated with adverse outcomes post kidney transplantation. METHODS: Our retrospective, single-centre analysis included all patients who received their kidney transplant between 2007 and 2017, with documented admission albumin levels prior to surgery. Survival analyses were undertaken to explore the relationship of pre-transplant hypoalbuminaemia versus other baseline variables upon post-transplant outcomes...
August 27, 2018: Nephrology
Fernanda Lourenço de Menezes, Paulo César Koch-Nogueira, Maria Luiza Dautro Moreira do Val, José Osmar Medina Pestana, Vanda Jorgetti, Marlene Antônia Dos Reis, Maria Luiza Gonçalves Dos Reis Monteiro, Heitor Pons Leite
AIM: To investigate if calcification and intimal media thickness of arteries are present in children and adolescents with end-stage renal disease and to describe the risk factors associated with these alterations. METHODS: In an observational, cross-sectional prospective study, 68 patients were evaluated at the time of renal transplantation. A fragment of the inferior epigastric artery was removed during surgery for histopathological analysis to verify the presence or not of arterial calcification...
August 26, 2018: Nephrology
Ryosuke Fujii, Asahi Hishida, Masahiro Nakatochi, Norihiro Furusyo, Masayuki Murata, Keitaro Tanaka, Chisato Shimanoe, Sadao Suzuki, Miki Watanabe, Nagato Kuriyama, Teruhide Koyama, Toshiro Takezaki, Ippei Shimoshikiryo, Kokichi Arisawa, Sakurako Katsuura-Kamano, Naoyuki Takashima, Tanvir C Turin, Kiyonori Kuriki, Kaori Endoh, Haruo Mikami, Yohko Nakamura, Isao Oze, Hidemi Ito, Michiaki Kubo, Yukihide Momozawa, Takaaki Kondo, Mariko Naito, Kenji Wakai
Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies (GWAS) have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11,283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort (J-MICC) Study sites...
August 26, 2018: Nephrology
Serena Low, Lim Su Chi, Xiao Zhang, Jiexun Wang, Su Jian Darren Yeo, Lee Ying Yeoh, Yan Lun Liu, Tavintharan Subramaniam, Chee Fang Sum
AIM: We aim to examine difference in incremental direct medical costs between non-progressive and progressive Chronic Kidney Disease (CKD) in Type 2 Diabetes Mellitus (T2DM) in Singapore. METHODS: This was a prospective study on 676 patients with T2DM attending a Diabetes Centre in a regional hospital. Annual direct medical costs were extracted from the administrative database. Ordinary least squares regression was used to estimate contribution of CKD progression to annual costs, adjusting for demographics and baseline clinical covariates...
August 24, 2018: Nephrology
Lu Wen, Zhanzheng Zhao, Zheng Wang, Jing Xiao, Henrik Birn, Jon Waarst Gregersen
AIM: Complement activation is involved in the pathogenesis and progression of IgA nephropathy (IgAN); however, the clinical implication of abnormal complement protein levels in serum and urine is not clear. To address this we analysed the correlation between disease activity and complement proteins in serum and urine from IgAN patients, and compared to patients with other types of chronic kidney disease (CKD) as well as healthy controls. METHODS: We included 85 Chinese patients with IgAN, 23 patients with non-proliferative CKD, and 20 healthy individuals...
August 23, 2018: Nephrology
Xuemei Geng, Xialian Xu, Yi Fang, Shuan Zhao, Jiachang Hu, Jiarui Xu, Ping Jia, Xiaoqiang Ding, Jie Teng
AIM: long noncoding RNAs (lncRNAs) have been shown to play a critical role in a variety of pathophysiological processes, such as cell proliferation, apoptosis and migration. However, there were few studies addressing the function of lncRNAs in renal ischemia/reperfusion (I/R) injury. Apoptosis is an important pathogenesis during I/R injury. Here we identified the effect of hypoxia-responsive lncRNA GAS5 on apoptosis in renal I/R injury. METHODS: I/R injury in mice or hypoxia/reoxygenation (H/R) in renal tubular epithelial cells (HK-2 cells) was practiced to induce apoptosis...
August 20, 2018: Nephrology
Shu-Li Wang, Yi-Wen Chiu, Lan-Fang Kung, Tzu-Hui Chen, Shih-Ming Hsiao, Pei-Ni Hsiao, Shang-Jyh Hwang, Hui-Min Hsieh
AIM: Self-care behavior represents the "action" element of self-management. This study aimed to use the Chronic Kidney Disease Self-Care (CKDSC) scale to examine factors associated with self-care and aspects of self-care deficits among patients with CKD stages in Taiwan. METHODS: A cross-sectional investigation was conducted using the CKDSC scale with a total of 449 CKD patients in Taiwan. The CKDSC is a 16-item questionnaire with five subscales, including medication adherence, diet control, exercise, smoking behaviors, and blood pressure monitoring...
August 20, 2018: Nephrology
Stephen R Ritchie, Emma Burrett, Patricia Priest, Juliet Drown, Susan Taylor, Jason Wei, John Collins, Mark G Thomas
AIM: For patients requiring haemodialysis, the risk of S. aureus disease is higher in those colonised and persists while the person requires haemodialysis, necessitating frequent decolonisation. However, the duration of successful decolonisation is not known. This study aimed to determine the duration of efficacy of decolonisation in intermittent and persistent S. aureus carriers requiring haemodialysis using two decolonisation strategies. METHODS: We screened 100 outpatients requiring haemodialysis for S...
August 20, 2018: Nephrology
Jessica A Vanderlinden, Amanda Ross-White, Rachel Holden, M Khaled Shamseddin, Andrew Day, J Gordon Boyd
IMPORTANCE: Cognitive dysfunction is reportedly highly prevalent among chronic kidney disease (CKD) patients. A variety of screening tools and neuropsychiatric batteries are utilized to quantify the magnitude and nature of this dysfunction in CKD patients. OBJECTIVE: To summarize the neurocognitive testing used and determine what degree cognitive dysfunction is reported in CKD patients. METHODS: Articles published in English containing consenting age of majority participants who were either: pre-dialysis patients, hemodialysis (HD) or peritoneal dialysis (PD) patients, or renal transplant recipients were considered...
August 10, 2018: Nephrology
Agnes Katalin Urban, Celine Foote, Frank P Brennan, Mark Brown, Brendon Lee
AIM: To explore the quality of deaths in the acute hospital under a Nephrology service at two teaching hospitals in Sydney with Renal Supportive Care services over time. METHODS: Retrospective chart review of all deaths in the years 2004, 2009 and 2014 at St George Hospital (SGH) and in 2014 at Concord Repatriation General Hospital (CRGH). Domains assessed were recognition of dying, invasive interventions, symptom assessment, anticipatory prescribing, documentation of spiritual needs and bereavement information for families...
August 9, 2018: Nephrology
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