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Ana Valente, Cristina Caetano, Telma Oliveira, Cristina Garagarza
OBJECTIVE: Evaluate which of two combinations of parameters based on ISRNM recommendations could better identify patients with Protein Energy Wasting (PEW) and to compare the relationship of these two combinations with other clinical and body composition parameters. DESIGN AND METHODS: This was a multicenter longitudinal study with 24 months of follow-up. The PEW patients were characterized by: Group A (GA ) - normalized Protein Catabolic Rate (nPCR) < 1.0 g/Kg/day, albumin < 3...
November 9, 2018: Nephrology
Yuta Tezuka, Izaya Nakaya, Keisuke Nakayama, Masaaki Nakayama, Mayumi Yahata, Jun Soma
AIM: Advanced glycation end products and their precursors cause vascular damage through oxidative stress. We investigated the hypothesis that methylglyoxal (MG), 3-deoxyglucosone (3-DG), and pentosidine influence outcomes of chronic kidney disease (CKD) patients. METHODS: We conducted a three-year prospective observational study involving 150 outpatients at CKD stages 3-5. At enrollment, MG, 3-DG, and pentosidine plasma concentrations were measured; patients were divided into tertiles according to the concentration of each substance...
November 8, 2018: Nephrology
Chi Yuen Cheung, Sydney Chi Wai Tang
Dialysis is the commonest modality of renal replacement therapy for patients suffering from end stage kidney disease. Different registry studies showed that the risks of overall cancer occurrence were significantly higher in chronic dialysis patients than in the age-matched general population. However, the frequency and pattern of different cancers may vary among different geographical areas. Since chronic dialysis patients tend to have multiple comorbidities and a shorter life expectancy, routine cancer screening in all dialysis patients may not be cost-effective; rather screening should be personalized according to the patient's expected survival, candidacy for kidney transplant together with patient preferences...
November 5, 2018: Nephrology
Gülsüm Özkan, Savaş Güzel, Reşit Volkan Atar, Çiğdem Fidan, Sonat Pınar Kara, Şükrü Ulusoy
BACKGROUND: Procollagen C-proteinase enhancer-1 (PCPE-1) is a 55-kDa glycoprotein which increases the activity of procollagen C-proteinases that break down C terminal propeptides. Studies have shown that PCPE-1 is involved in the fibrotic process that occurs in various tissues and organs. Our review of the literature revealed no data concerning the relation between PCPE-1 and chronic kidney disease (CKD). The purpose of this study was to determine PCPE-1 levels in CKD. METHODS: One hundred thirty-one CKD patients and 34 healthy controls were included in our study...
November 4, 2018: Nephrology
Theepika Rajkumar, Shenaaz Mazid, Mirna Vucak-Dzumhur, Tanya M Sykes, Grahame J Elder
INTRODUCTION: Kidney and simultaneous pancreas kidney (SPK) transplant recipients are younger and fitter than most other dialysis patients, but are also more vulnerable in areas of social, emotional and physical interaction. Few studies have tracked their post-transplant health related quality of life (HRQoL). AIM: To assess HRQoL following kidney and SPK transplantation, with comparison to dialysis patients, people with multiple co-morbidities and general population data...
November 4, 2018: Nephrology
Shi Zhou Choo, Emily J See, Rosemary E Simmonds, Christine A Somerville, John W M Agar
AIM: The Barwon Health nocturnal home haemodialysis (NHHD) program was established in 2000 as the first formal NHHD program in Australia. We aimed to assess reasons for and factors associated with program exit, and technique and patient survival rates. METHODS: This retrospective audit included all patients enrolled in the NHHD program from 1st September 2000 to 31st July 2017. The primary outcome was technique failure, defined as transfer to satellite haemodialysis (HD) or to peritoneal dialysis (PD) for greater than or equal to 60 days, or death...
November 4, 2018: Nephrology
Nika Kojc, Alenka Bahovec, Tanja Kersnik Levart
No abstract text is available yet for this article.
November 4, 2018: Nephrology
Yogavijayan Kandasamy, Donna Rudd, Eugenie R Lumbers, Roger Smith
AIM: Indigenous Australians have an increased risk of developing Chronic Kidney Disease (CKD). Indigenous women have a higher rate of CKD than men. In a cohort of Indigenous and non-Indigenous preterm neonates, we assessed total renal volume (TRV) (a proxy indicator for nephron number). We hypothesised that there would be no difference in renal volume between these two groups at term corrected (37 weeks gestation). METHODS: Normally grown preterm neonates less than 32 weeks of gestation were recruited and at term corrected dates, the neonates underwent renal ultrasonography (TRV measurements), urine microalbumin-creatinine ratio (ACR) and serum analysis for Cystatin C measurement for eGFR calculation...
October 23, 2018: Nephrology
Junlin Zhang, Rui Zhang, Yiting Wang, Yucheng Wu, Hanyu Li, Qianqian Han, Ruikun Guo, Tingli Wang, Jiali Wang, Pramesh Grung, Fang Liu
BACKGROUND: Chronic low-grade inflammation related to diabetic nephropathy (DN) may affect the serum neutrophil-lymphocyte ratio (NLR). We aimed to examine the cross-sectional relationships of NLR with renal function and structural lesions of DN in patients with type 2 diabetes mellitus (T2DM). METHODS: The study retrospectively included 247 patients with T2DM and biopsy-proven DN. The severity of different pathological lesions was evaluated based on the criteria of Renal Pathology Society...
October 22, 2018: Nephrology
Haruka Yasuda, Yasunori Iwata, Satoshi Nakajima, Kengo Furuichi, Taito Miyake, Norihiko Sakai, Shinji Kitajima, Tadashi Toyama, Yasuyuki Shinozaki, Akihiro Sagara, Taro Miyagawa, Akinori Hara, Miho Shimizu, Yasutaka Kamikawa, Kouichi Sato, Megumi Oshima, Shiori Yoneda-Nakagawa, Shuichi Kaneko, Takashi Wada
AIM: High glucose (HG) induces endothelial injury in vasculature, leading to tissue injury in diabetic condition. Therefore, diabetes is one of the major cause of end stage kidney disease as well as cardiovascular diseases. Chronic inflammation is involved in the progression of HG induced cell injury. Recently, it has been reported that erythropoietin (EPO) protects the tissues from some kind of injury, such as hypoxia and mechanical stress. However, the contribution of EPO to HG induced tissue injury remains to be explored...
October 22, 2018: Nephrology
Yasuhiro Onishi, Haruhito A Uchida, Takeuchi Hidemi, Yuki Kakio, Hitoshi Sugiyama, Jun Wada, Noriaki Shimada, Hironobu Tokumasu, Masaki Fukushima, Kenichiro Asano
AIM: Deteriorated health-related quality of life (HRQOL) is associated with increased risk for death in both CKD and ESRD patients, however, the impact of HRQOL on CKD progression is not well investigated. METHODS: We aimed to evaluate the association between HRQOL and CKD progression in Japanese patients with CKD. One hundred and three outpatients who visited the department of nephrology at our hospital (mean eGFR; 32.1±11.2 mL/min/1.73m2 ) between April 2007 and March 2012 were enrolled in this study...
October 17, 2018: Nephrology
Teng-Hsiang Chang, Ping-Fang Chiu, Chun-Chieh Tsai, Chin-Hua Chang, Chia-Lin Wu, Chew-Teng Kor, Jhao-Rong Li, Cheng-Ling Kuo, Ching-Shan Huang, Cheng-Chung Chu, Chih-Ming Lin, Chia-Chu Chang
BACKGROUND AND PURPOSE: Recombinant tissue plasminogen activator (rt-PA) administration is the most prevalent treatment for acute ischemic within golden time. However, the effects of rt-PA on the kidney function in such patients remain unknown. This study determined long-term renal outcomes in patients with acute ischemic stroke receiving systemic rt-PA. METHODS: We enrolled patients who were hospitalized for acute ischemic stroke from January 2001 to January 2017...
October 17, 2018: Nephrology
Cheney Li, Long Zhao, Yanfei Wang, Lin Che, Hong Luan, Congjuan Luo, Yan Xu
AIM: Studies have shown that cysteine-rich protein 61 (Cyr61) increased in the post-ischemic human kidney tissue. However, it is still unknown whether Cyr61 can be used as a biomarker in kidney ischemia/reperfusion (I/R) injury METHODS: Microarray data were collected from GSE58438 and GSE52004. The rat I/R model was established to evaluate the mRNA and protein expression of Cyr61, localization of Cyr61 by immunohistochemical and immunofluorescence staining, and changes in serum creatinine (Scr) at the same time...
October 17, 2018: Nephrology
Yu-Hsiang Chou, Wei-Lieh Huang, Chin-Hao Chang, Cheryl C H Yang, Terry B J Kuo, Shuei-Liong Lin, Wen-Chih Chiang, Tzong-Shinn Chu
AIM: Autonomic dysfunction contributes to cardiovascular morbidity/mortality and can be evaluated with heart rate variability (HRV). This study is to evaluate the prognostic significance of HRV on renal function in non-dialysis chronic kidney disease (CKD) patients. METHODS: We enrolled 326 non-dialysis CKD patients in this prospective observational study. The median follow-up period was 2.02 years. Five-minutes of electrocardiography recordings obtained at enrollment were reprocessed to assess HRV...
October 17, 2018: Nephrology
Anh Nguyen, Mukunda Kafle, Kamal Sud, Vincent Lee
AIMS: (1) To determine incidence and reasons for transfer from maintenance hemodialysis to peritoneal dialysis; (2) To compare mortality of hemodialysis patients transferred to peritoneal dialysis with those who initiated and remained on peritoneal dialysis. METHODS: A 1:2 matched cohort of ANZDATA included patients dialyzing over 3 months dividing into 2 groups. Group A (hemodialysis to peritoneal dialysis) was compared to group B (initiated and remained on peritoneal dialysis) and matched peritoneal dialysis group (Group C)...
October 16, 2018: Nephrology
Meg Jardine, Robert Commons, Janak de Zoysa, Muh Geot Wong, Nicole Gilroy, Julianne Green, Belinda Henderson, Rhonda Stuart, David Tunnicliffe, Carolyn van Eps, Eugene Athan
AIM: There is no national consensus on infection control in haemodialysis units in Australia and New Zealand. The primary aim of this guideline was to provide recommendations on screening for blood-borne viruses and multi-resistant organisms for dialysis units based on the available evidence. METHODS: The KHA-CARI overall approach to guideline development follows the GRADE framework. A facilitated workshop was conducted to ensure that patient and caregiver concerns were considered...
October 16, 2018: Nephrology
Surachet Vongsanim, Stanley Fan, Andrew Davenport
BACKGROUND: Heat sterilisation of peritoneal dialysis (PD) dialysates leads to the generation of advanced glycation products (AGEs), which can then deposit in the skin and be measured by skin autofluorescence (SAF). Newer biocompatible dual chamber dialysates contain less AGEs. We wished to determine whether the use of these newer dialysates resulted in lower SAF. METHODS: SAF was measured using the AGE reader, which directs ultraviolet light, intensity range 300-420 nm (peak 370 nm) in patients established on PD for > 3 months using glucose containing dialysates...
October 8, 2018: Nephrology
Xiaolei Chen, Yiling Cao, Zheng Wang, Dongmei Zhang, Wanxin Tang
AIM: Hypertensive nephropathy (HTN) is one of the leading causes of end-stage renal disease and is closely associated with inflammation and tubule-interstitial fibrosis. The molecular mechanism underlying HTN remains unclear. This study utilized bioinformatic analysis to identify the novel gene targets for HTN. METHODS: We downloaded the microarray data of GSE99325 and GSE32591 from Gene Expression Omnibus. The dataset comprised 20 HTN and 15 normal samples. The differentially expressed genes (DEGs) were identified, and then gene ontology (GO) enrichment was performed, and a GO tree was constructed by using clusterProfiler and ClueGO...
October 8, 2018: Nephrology
K Ducharlet, V Sundarajan, J Philip, J Weil, N Barker N, R G Langham, J Burchell, H Gock
Symptom and quality of life (QOL) measures in patients with advanced chronic kidney disease (CKD) are recognised indicators of patient-centred care and represent important research, quality and clinical measures. This study examined relationships between symptom burden, QOL and functional status and associations of symptoms and mortality risk. A multisite longitudinal cohort analysis was undertaken in CKD stage 4/5 (no dialysis, ND) and dialysis patients. Patients completed symptom and QOL measures (Palliative Care Outcome Symptom Score (POS-S renal) [1], World Health Organisation QOL, WHOQOL-BREF) [2] and Karnofsky Performance scale [3]...
October 8, 2018: Nephrology
Brendan Smyth, Sradha Kotwal, Martin Gallagher, Nicholas A Gray, Kevan Polkinghorne
AIM: Dialysis catheter associated infections (CAI) are a serious and costly burden on patients and the healthcare system. Many approaches to minimising catheter use and infection prophylaxis are available and the practice patterns in Australia and New Zealand are not known. We aimed to describe dialysis catheter management practices in dialysis units in Australia and New Zealand. METHODS: Online survey comprising 51 questions, completed by representatives from dialysis units from both countries...
September 28, 2018: Nephrology
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