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Keiko Tanaka, Hitoshi Sugiyama, Toshio Yamanari, Koki Mise, Hiroshi Morinaga, Masashi Kitagawa, Akifumi Onishi, Ayu Ogawa-Akiyama, Katsuyuki Tanabe, Jun Eguchi, Yasukazu Ohmoto, Kenichi Shikata, Jun Wada
AIM: Trefoil factor 3 (TFF3) is a small peptide that is involved in mucosal protection. TFF3 is widely expressed in multiple tissues including kidney tissue. Previous studies have reported that the levels of urinary TFF3 are significantly increased in patients with chronic kidney disease. The aim of this study is to detect the TFF3 mRNA in kidney and elucidate the relationship between renal TFF3 mRNA and tubulointerstitial fibrosis in IgA nephropathy (IgAN). METHODS: We investigated the renal mRNA expression of TFF3 by real time PCR analysis in biopsy specimens from patients with IgAN, other glomerulonephritis (OGN), and minor glomerular abnormalities (MGA)...
July 10, 2018: Nephrology
Boonphiphop Boonpheng, Charat Thongprayoon, Karn Wijarnpreecha, Juan Medaura, Fouad T Chebib, Wisit Cheungpasitporn
BACKGROUND: Complications related to peritoneal dialysis (PD) in patients with autosomal dominant polycystic kidney disease (ADPKD) including intraperitoneal rupture of renal cyst, hernia, membrane failure, and peritonitis have been reported. However, long-term clinical outcomes of ADPKD patients on PD remain unclear. We performed this meta-analysis to assess the risks of death, technique failure, and peritonitis in ADPKD patients on PD. METHODS: A systematic review was conducted using MEDLINE, EMBASE, Cochrane databases from inception through October 2017 to identify studies that evaluated outcomes of ADPKD patients on PD including the risks of death, technique failure, and peritonitis...
June 27, 2018: Nephrology
Diefei Liang, Zijiao Song, Weiwen Liang, Yan Li, Shanying Liu
AIMS: Metformin is a biguanide derivative widely used for the treatment of type 2 diabetes mellitus. Recent evidence implicates that this anti-hyperglycemic drug exerts renal protective effects, yet the mechanisms remain poorly understood. MCP-1 has been recognized as a key mediator of renal fibrosis in chronic kidney diseases including diabetic nephropathy. This study aimed to investigate the effects of metformin on TGF-β1-induced MCP-1 expression and the underlying mechanisms in rat renal tubular epithelial cells...
June 22, 2018: Nephrology
Carlos K H Wong, Julie Y Chen, Samuel K S Fung, Wai Kei Lo, Sing Leung Lui, Daniel T M Chan, Yuk Lun Cheng, Irene Kong, Eric Y F Wan, Cindy L K Lam
BACKGROUND: To compare the health-related quality of life (HRQOL) and health utility of Chinese patients with end-stage renal disease (ESRD) undergoing nocturnal home haemodialysis against those patients undergoing other modes of dialysis. METHODS: Chinese ESRD patients undergoing nocturnal home haemodialysis were recruited in renal specialist outpatient clinics at three public hospitals in Hong Kong. SF-12 Health Survey (SF-12) was used to measure HRQOL and generate the SF-6D heath utility score...
June 21, 2018: Nephrology
Jessica Kong, Matthew Davies, Peter Mount
In contrast to peritoneal dialysis, residual kidney function is commonly disregarded for haemodialysis patients, and not regularly monitored or taken into account in routine clinical care. This is despite evidence that higher levels of residual kidney function in haemodialysis patients associate with better outcomes including survival, total solute clearance, nutrition, inflammation, and fluid balance. This review aims to summarise the clinical effects of residual kidney function specifically in haemodialysis patients...
June 19, 2018: Nephrology
Francesco Porta, Licia Peruzzi, Roberto Bonaudo, Silvia Pieretti, Marta Busso, Enrico Cocchi, Alessandra Conio, Veronica Pagliardini, Marco Spada
Severe urea cycle defects (UCDs), organic acidemias (OAs), and maple syrup urine disease (MSUD) are life-threatening disorders presenting in the first days of life. Renal replacement therapy (RRT) is an emergency option in affected newborns, mostly performed as ultima ratio. We report our 10-year experience using emergency RRT in newborns with UCDs, OAs, and MSUD. Twelve newborns (8 with UCDs, 2 with methylmalonic acidemia, and 2 with MSUD) underwent emergency RRT. The overall survival rate to RRT was 58.3%...
June 10, 2018: Nephrology
Chung Hee Baek, Hyosang Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
AIM: ABO-incompatible (ABOi) kidney transplantation (KT) has become a routine procedure with graft survival rates comparable to those of ABO-compatible KT. However, the clinical significance of the isoagglutinin titer in ABOi KT remains uncertain. Therefore, in this study, we analyzed the clinical outcomes of ABOi KT according to the baseline and postoperative isoagglutinin titer. METHODS: All patients who received ABOi KT between 2009 and 2013 were reviewed and followed up until December 2016...
June 7, 2018: Nephrology
Ricky W K Lau, Bo Wang, Sharon D Ricardo
Recent developments in targeted gene editing have paved the way for the wide adoption of cluster regular interspaced short palindromic repeats (CRISPR)-associated protein-9 nucleases (Cas9) as a RNA guide molecular tool to modify the genome of eukaryotic cells or animals. Theoretically, the translation of CRISPR-Cas9 can be applied to the treatment of inherited or acquired kidney disease, kidney transplantation and genetic corrections of somatic cells from kidneys with inherited mutations such as polycystic kidney disease...
May 30, 2018: Nephrology
Hiroko Hamatani, Toru Sakairi, Hidekazu Ikeuchi, Yoriaki Kaneko, Akito Maeshima, Yoshihisa Nojima, Keiju Hiromura
BACKGROUND: Wilms' tumor 1 (WT1) is essential for normal podocyte function. Previous reports have shown that the WT1 promoter is often methylated in cancers, leading to transcriptional silencing. Transforming growth factor-β1 (TGF-β1) is reported to downregulate WT1 expression in podocytes. Based on the hypothesis that epigenetic modification plays a role in this process, we examined whether TGF-β1 affects the methylation status of WT1 regulatory regions. METHODS: Conditional immortalized human podocytes were treated with TGF-β1...
May 30, 2018: Nephrology
Dharshan Rangaswamy, Kamal Sud
With increasing longevity and presence of multiple co-morbidities, a significant proportion of hospitalized patients and an even larger population in the community is at increased risk for developing an episode of acute kidney injury (AKI). Because of improvements in short term outcomes following an episode of AKI, survivors of an episode of AKI are now predisposed to develop its long-term sequel. Identification of risk for progression to chronic kidney disease (CKD) is complicated by the absence of good biomarkers that identify this risk and the variability of risk associated with clinical factors including, but not limited to number of AKI episodes, severity, duration of previous AKI and pre-existing chronic kidney disease that has made prediction for long-term outcomes in survivors of AKI more difficult...
May 27, 2018: Nephrology
Hyunsuk Kim, Junga Koh, Sue K Park, Kook Hwan Oh, Yeong Hoon Kim, Yaeni Kim, Curie Ahn, Yun Kyu Oh
AIM: The aim of this study was to describe the baseline characteristics of autosomal dominant polycystic kidney disease (ADPKD) in a cohort of Korean patients with chronic kidney disease (CKD). METHODS: From April 2011 to February 2016, patients with CKD stage 1 to 5 (pre-dialysis) were enrolled as an ADPKD subcohort of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease. Baseline characteristics, the correlation of kidney and liver volume and kidney function, and the factors associated with kidney function were analyzed...
May 24, 2018: Nephrology
Talia Gutman, Pamela Lopez-Vargas, Karine E Manera, Jonathan C Craig, Martin Howell, David Tunnicliffe, Laura J James, Rob MacGinley, Emily See, Jeffrey Wong, David Voss, John Saunders, Solomon Menahem, Shilpanjali Jesudason, Allison Tong, Paul Champion de Crespigny
AIMS: Percutaneous renal biopsy is often essential for providing reliable diagnostic and prognostic information for people with suspected kidney disease, however the procedure can lead to complications and concerns among patients. This study aims to identify and integrate patient priorities and perspectives into the Kidney Health Australia - Caring for Australasians with Renal Impairment clinical practice guidelines for renal biopsy, to ensure patient-relevance. METHODS: We convened a workshop, consisting of three simultaneous focus groups and a plenary session, with ten patients who had undergone a renal biopsy and seven caregivers...
May 23, 2018: Nephrology
Jann Patrick Ong, Ron Wald, Marc B Goldstein, Jonathon Leipsic, Mercedeh Kiaii, Djeven P Deva, Anish Kirpalani, Laura Jimenez-Juan, Olugbenga Bello, Paymon M Azizi, Rachel M Wald, Graham A Wright, Ziv Harel, Kim A Connelly, Andrew T Yan
AIM: Intensified haemodialysis is associated with regression of left ventricular (LV) mass. Compared to LV ejection fraction, LV strain allows more direct assessment of LV function. We sought to assess the impact of in-centre nocturnal haemodialysis (INHD) on global LV strain (radial, circumferential, and longitudinal) and torsion by cardiac MRI (CMR). METHODS: In this prospective, 2-centre cohort study, 37 participants on conventional haemodialysis (CHD, 3-4 hours/session for 3 sessions/week) converted to INHD (7-8 hours/session for 3 sessions/week) and 30 participants continued CHD...
May 21, 2018: Nephrology
Rachael C Walker, Derisha Naicker, Tonya Kara, Suetonia C Palmer
RATIONALE AND OBJECTIVE: Kidney transplantation offers improved quality of life and life expectancy compared with dialysis for children. This study aims to understand the experiences and expectations of children during the kidney transplantation process to inform clinical care. STUDY DESIGN: Face-to-face, semi-structured interviews. SETTING AND PARTICIPANTS: We interviewed 13 children and adolescents aged between 7 and 17 years old in New Zealand who had received a kidney transplantation...
May 21, 2018: Nephrology
Ru Yu Tan, Michelle Manning, Jacqueline Spurway, Thulasi Jegatheesan, Michelle Bertram, Lisa Phipps, Jan Swinnen
AIM: Formation of autogenous arteriovenous fistula (AVF) in patients with chronic kidney disease (CKD) is complicated by a high primary failure rate due to pre-existing vascular damage. We hypothesized that Venous Preservation Scan (VPS) - early (months to years before AVF creation) vascular mapping followed by vasculature preservation is effective in protecting the patient's best "for fistula" vasculature. This study was performed to evaluate the impact of VPS on AVF outcomes...
May 20, 2018: Nephrology
Vikraman G, Sanjay Kumar Agarwal, Sandeep Agarwal, Sandeep Mahajan, Dipankar Bhowmik, Soumita Bagchi
BACKGROUND: Few studies have assessed the impact of infections after renal transplantation (RTX) in low and middle income countries. This single center study aimed to delineate the profile and impact of infections requiring hospitalisation (IRH) occurring in the first year after RTX in India. METHOD: Patients who underwent RTX between July 2012 and June 2015 were followed up for 12 months after transplantation. RESULTS: 60.2% of the 387 patients studied had atleast one IRH and total 492 infections were diagnosed...
May 14, 2018: Nephrology
Radhika Sharma, Priya Battu, Mandakini Singla, Neha Goyal, Vijay L Sharma
AIM: Isoniazid (INH), Rifampicin (RIF) and Pyrazinamide (PZA) are part of first-line anti-tuberculosis therapy used against infection caused by Mycobacterium tuberculosis. However these drugs are known to be potentially harmful as these are associated with numerous side effects and when taken together their harmful outcomes are elevated in a synergistic manner. Identification of possible mechanism underlying RIF+INH+PZA induced nephrotoxicity may be advantageous in developing strategies to prevent their toxic implications...
May 8, 2018: Nephrology
Edlyn Gui Fang Tan, Irene Teo, Eric A Finkelstein, Choong Meng Chan
BACKGROUND: In Singapore, most elderly end stage renal disease (ESRD) patients choose dialysis over palliative management. However, dialysis may not be the optimal treatment option given only moderate survival benefits and high costs and treatment burden compared to non-dialysis management. Elderly patients may therefore come to regret this decision. This study investigated (1) extent of patients' decision regret after starting dialysis, and (2) potentially modifiable predictors of regret: satisfaction with chronic kidney disease education, decisional conflict, and decision-making involvement...
May 7, 2018: Nephrology
Shi Z Choo, Kevan R Polkinghorne, Peter G Kerr
AIM: Extended-hours haemodialysis has long been regarded as the optimal form of dialysis for solute clearance. With emerging benefits of haemodiafiltration, we wanted to compare these two head-to-head. METHODS: In this randomised cross-over trial, we recruited existing nocturnal haemodialysis patients, who had not been hospitalised in the prior three months. After a baseline 8-hour haemodialysis session, subjects were randomised to either 2 weeks of 8-hour haemodialysis or 4-hour haemodiafiltration with cross-over to the alternative treatment after a 2-week washout period...
May 2, 2018: Nephrology
Hywel Lloyd, Grace Li, Andrew Tomlin, Murray W Tilyard, Robert Walker, John Schollum
BACKGROUND: While the prevalence of end stage kidney disease in New Zealand (NZ) is well defined, the prevalence of CKD in NZ is unknown. AIM: To estimate the prevalence of and risk factors for CKD in the southern region of New Zealand METHODS: A retrospective electronic health record cohort study using data from the Southern Primary Care register covering 94% of the population. Patients, 20 years or older were identified and linked to laboratory results for serum creatinine and urinary albumin excretion...
May 2, 2018: Nephrology
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