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Journal of Cutaneous Medicine and Surgery

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https://www.readbyqxmd.com/read/29231053/the-contribution-of-malodour-in-quality-of-life-of-patients-with-hidradenitis-suppurativa
#1
Afsaneh Alavi, Delaram Farzanfar, Rosa Kyuwon Lee, Dalal Almutairi
BACKGROUND: Malodourous discharge in patients with hidradenitis suppurativa (HS) has a strong psychosocial impact and is often reported as a source of embarrassment, low self-esteem, social stigma, and barriers to interpersonal relationships. Malodour is a maker of bacterial colonization, and its role in HS is understudied. OBJECTIVES: The aim of this study is to assess the relationship between severity of malodourous discharge and quality-of-life impairment in patients with HS...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29202605/toxic-epidermal-necrolysis-spectrum-management-at-sunnybrook-health-sciences-centre-our-multidisciplinary-approach-after-review-of-the-current-evidence
#2
Alexandra Mereniuk, Alejandra Jaque, Marc G Jeschke, Neil H Shear
Toxic epidermal necrolysis spectrum (TENS) is a rare yet severe adverse drug reaction associated with a high mortality rate. Beyond supportive care, there is still no established therapy for TENS, although recent meta-analyses and UK guideline recommendations have attempted to offer a review of relevant literature on this difficult topic. As most directed treatments lack clear consensual evidence, care centres often resort to establishing their own strategies. As Canada's largest adult burn centre and the provincial reference centre for most burn patients in Ontario, our team at the Ross Tilley Burn Centre, in collaboration with the Department of Dermatology at Sunnybrook Health Sciences Centre, Toronto, Canada, has managed over 60 confirmed cases of TENS over the past 2 decades...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29191054/onychomycosis-and-chronic-fungal-disease-exploiting-a-commensal-disguise-to-stage-a-covert-invasion
#3
Aditya K Gupta, Jessie Carviel, Neil H Shear
Onychomycosis is a chronic fungal infection that is recalcitrant to treatment and often results in relapse. New evidence suggests that disease prognosis may be linked to pathogens manipulating host immune responses. Therefore, individuals with specific mutations, including those affecting pattern recognition receptors or the interleukin (IL)-17 and IL-22 pathways, may be more susceptible to infection. Moreover, it is recommended that those with a family history of immune mutations or predisposition to fungal disease be treated aggressively for onychomycosis prior to symptom progression...
November 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29191053/diagnosis-and-management-of-conjunctivitis-for-the-dermatologist
#4
Melinda Gooderham, Julian McDonald, Kim Papp
Atopic dermatitis is a chronic, sometimes relapsing inflammatory skin condition that presents with pruritus and characteristic skin manifestations. Conjunctivitis is a common ocular comorbidity affecting almost half of patients with the risk increasing with atopic dermatitis severity. Recent targeted biologic therapies that successfully treat atopic skin disease, including dupilumab, which blocks interleukin (IL)-4 and IL-13, as well as agents that block IL-13 alone, have been associated with an increased rate of conjunctivitis in clinical trials...
November 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29137492/a-guide-to-topical-vehicle-formulations
#5
Julia N Mayba, Melinda J Gooderham
Adherence to topical treatment for a variety of chronic skin conditions, such as psoriasis, acne, and atopic dermatitis, is known to be very poor. A number of factors contribute to this phenomenon, including lack of treatment efficacy and patient concerns regarding side effects, among others. At the forefront of barriers facing optimal patient adherence to topical treatment is choosing the ideal topical vehicle formulation. Medical professionals have demonstrated a lack of understanding with respect to the composition and nomenclature of the various topical formulations...
November 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29134825/assessing-the-need-for-a-comprehensive-acne-quality-of-life-scale-for-face-and-torso-acne
#6
Chelsea McLellan, Marc Philip Frey, Jerry Tan
PURPOSE: While acne, a common condition, largely involves the face, chest, and back, current acne quality-of-life measures focus primarily on facial acne. The purpose of this study was to assess the need for a comprehensive quality-of-life measure intended for use with patients who have facial and/or torso acne. METHODS: We evaluated the need for a comprehensive quality-of-life scale for facial and torso acne based on data from an epidemiological survey (N = 690) in which participants were grouped according to the location of their acne (face, torso, or both) and where quality of life was assessed...
November 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29098866/derivation-evaluation-and-validation-of-illustrations-of-key-counselling-points-for-a-pediatric-eczema-action-plan
#7
Alana McEvoy, Maxwell B Sauder, Katherine McDonald, Phillipe Suter, Annie Pouliot, Roger Zemek, Nordau Kanigsberg, Regis Vaillancourt, Michele L Ramien
BACKGROUND: Current eczema action plans (EAP) are based on written instructions without illustrations. Incorporating validated illustrations into EAPs can significantly improve comprehension and usability. OBJECTIVE: To produce and validate a set of illustrations for key counselling points of a pediatric EAP. METHODS: Illustrations were developed using key graphic elements and refined by subject experts. Illustrations were evaluated during one-on-one structured interviews with parents/caregivers of children ages 9 and younger, as well as with children ages 10 to 17 years between September 2015 and June 2016...
November 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29082775/a-treatment-algorithm-for-moderate-to-severe-atopic-dermatitis-in-adults
#8
Charles W Lynde, Marc Bourcier, Melinda Gooderham, Lyn Guenther, Chih-Ho Hong, Kim A Papp, Yves Poulin, Gordon Sussman, Ronald Vender
BACKGROUND: Atopic dermatitis (AD) is a common and chronic inflammatory skin disease. Approximately 10% of adults with AD do not respond adequately to topical therapies and require phototherapy and/or systemic therapy. OBJECTIVE: To provide a patient-focused approach to the identification and management of adults with AD who require systemic treatment. METHODS: A working group of clinicians experienced in managing AD was convened to review and discuss current evidence on the identification and clinical management of adults with moderate to severe AD...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29067826/yellow-nail-syndrome-presenting-with-a-pericardial-effusion-a-case-report-and-review-of-the-literature
#9
Laura C Soong, Richard M Haber
Yellow nail syndrome (YNS) is a constellation of clinical findings including at least 2 of the 3 features of thickened yellow nails, respiratory tract involvement, and lymphedema. We report the case of a middle-aged man presenting with dystrophic, thickened yellow nails; an idiopathic pericardial effusion in the absence of pleural effusion(s); and unilateral apical bronchiectasis found on computed tomography of the chest. This represents a unique presentation of YNS as the first report of a patient with YNS and a pericardial effusion in the absence of pleural effusions and lymphedema and is the 11th case report of YNS with pericardial effusion...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29056083/frontal-fibrosing-alopecia-update-and-review-of-challenges-and-successes
#10
Derek To, Jennifer Beecker
BACKGROUND: Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris (LPP) and is characterised as a progressive cicatricial alopecia affecting the frontotemporal hairline. OBJECTIVES: To perform a comprehensive, up-to-date review of the etiopathogenesis, clinicopathological features, and therapeutic options for FFA. METHODS: A literature search was conducted using PubMed (from 1946) and Cochrane (from 1991) databases on March 7, 2017...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29056081/the-risks-and-benefits-of-cannabis-in-the-dermatology-clinic
#11
Gurbir Dhadwal, Mark G Kirchhof
Cannabis ( Cannabis sativa/indica), also known as marijuana, has been used for medicinal and recreational purposes for millennia. There has been a recent trend to legalize the use of cannabis, as illustrated by the recent legalization votes in numerous states in the United States and legislation in Canada to allow recreational cannabis use. With this increasing consumption of cannabis, dermatologists will see increased pressure to prescribe cannabis and will see the side effects of cannabis use with greater frequency...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29056080/persistency-of-biologic-therapies-for-plaque-psoriasis-in-2-large-community-practices
#12
Luvneet Verma, Julia N Mayba, Melinda J Gooderham, Ankush Verma, Kim A Papp
BACKGROUND: Biologics have transformed the management of moderate to severe psoriasis. The persistency of biologics lacks real-world data. OBJECTIVES: To quantify drug survival of infliximab (IFX), adalimumab (ADA), etanercept (ETA), and ustekinumab (UST) and to identify potential factors affecting drug survival. METHODS: An observational, retrospective 2-centre study consisting of 906 patients from private practices in Ontario between July 2003 and June 13, 2016, was conducted, including patients with plaque psoriasis receiving commercial treatment with ADA, ETA, IFX, and UST...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29056071/hidradenitis-suppurativa-a-novel-model-of-care-and-an-integrative-strategy-to-adopt-an-orphan-disease
#13
Wayne Gulliver, Ian D R Landells, David Morgan, Syed Pirzada
Unnecessary investigations, inappropriate treatment, worsening disease, and frustration for both patients and health care professionals are the hallmarks of hidradenitis suppurativa (HS) management. In light of a new treatment algorithm and biologic therapies made available to patients, an HS model of care is outlined in this article. The recommendations and management strategy presented here have been developed to help address the currently unmet needs of this patient population. The patient-centred model of care and disease management strategies were developed through the guidance and recommendations of HS medical experts in Newfoundland and Labrador...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29039219/allergic-contact-cheilitis-from-a-variety-of-lip-balm-ingredients
#14
Linghong Linda Zhou, Melanie Pratt
No abstract text is available yet for this article.
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29020800/an-approach-to-minimising-risk-of-adrenal-insufficiency-when-discontinuing-oral-glucocorticoids
#15
Mathew N Nicholas, Stephanie K Li, Marlene Dytoc
Oral glucocorticoids are commonly used across every field of medicine; however, discontinuing them in patients can be challenging. The risk of acute adrenal crises secondary to glucocorticoid withdrawal can be fatal and arises from chronic suppression of the adrenal glands. Identifying risk factors for adrenal suppression in dermatological patients, such as doses greater than 5 to 7.5 mg of prednisone equivalent, duration of glucocorticoid use greater than 3 weeks, certain medications, and comorbidities, can help risk-stratify patients...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28992738/preliminary-validation-of-the-hs-qol-a-quality-of-life-measure-for-hidradenitis-suppurativa
#16
Chelsea McLellan, Mia Sisic, Hazel H Oon, Jerry Tan
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with adverse physical and psychosocial impacts. The development of an HS quality-of-life measure, HS-QoL, has been recently described. OBJECTIVE: This study was designed to validate the HS-QoL. METHOD: Fifty-five patients with HS from 4 dermatology clinics completed the 30-minute online survey. Item reduction, reliability (internal consistency), and correlation analysis (to assess convergent validity) were conducted...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28991496/bed-bug-bites-limited-to-exposed-skin
#17
Whitney General, Christina Wlodek, Giles Dunnill
No abstract text is available yet for this article.
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28978228/an-unusual-childhood-mole-pigmented-basal-cell-cancer-mimicking-macular-seborrheic-keratosis
#18
Ramya Vangipuram, Kevin G Sharghi, Stephen K Tyring
No abstract text is available yet for this article.
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29117719/introducing-a-workplace-prescription-to-facilitate-return-to-work-for-workers-with-occupational-contact-dermatitis
#19
Irena Kudla, Marie-Claude Houle, Yuliya Velykoredko, Pilar Gomez, Joel DeKoven, Sandy Skotnicki, D Linn Holness
No abstract text is available yet for this article.
November 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29117718/deep-tissue-sequencing-using-augmented-intelligence-to-probe-melanocytic-lesions
#20
John Arlette, Alexander Wong, Iman Khodadad, Farnoud Kazemzadeh
No abstract text is available yet for this article.
November 2017: Journal of Cutaneous Medicine and Surgery
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