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Acta Neuropsychiatrica

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https://www.readbyqxmd.com/read/28718394/multiple-possible-inaccuracies-cast-doubt-on-a-recent-report-suggesting-selective-serotonin-reuptake-inhibitors-to-be-toxic-and-ineffective
#1
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
According to a systematic review on the use of selective serotonin reuptake inhibitors (SSRIs) in adult depression that was recently published in BMC Psychiatry, the results of which have been widely disseminated in lay media, these drugs increase the risk for serious adverse events (SAEs) while exerting poor antidepressant efficacy. A cursory analysis, however, suggests the analysis of SAEs conducted by the authors to be marred by both methodological inaccuracies and blatant errors. After having corrected for these apparent mistakes, we conducted a sensitivity analysis in which we also accounted for a possible moderating effect of age; while this suggests SSRIs to be safe drugs in the non-elderly, they do confirm what is already known, that is, that they may enhance the risk for SAEs in the old...
July 18, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28714423/distinctive-neuropsychological-profiles-differentiate-patients-with-functional-memory-disorder-from-patients-with-amnestic-mild-cognitive-impairment
#2
Sarah J Wakefield, Daniel J Blackburn, Kirsty Harkness, Aijaz Khan, Markus Reuber, Annalena Venneri
OBJECTIVES: Patients with functional memory disorder (FMD) report significant memory failures in everyday life. Differentiating these patients from those with memory difficulties due to early stage neurodegenerative conditions is clinically challenging. The current study explored whether distinctive neuropsychological profiles could be established, suitable to differentiate patients with FMD from healthy individuals and those experiencing amnestic mild cognitive impairment (a-MCI). METHODS: Patients with a clinical diagnosis of FMD were compared with patients with a-MCI, and healthy matched controls on several tests assessing different cognitive functions...
July 17, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28566105/regional-differences-in-dendritic-spine-density-confer-resilience-to-chronic-social-defeat-stress
#3
Youge Qu, Chun Yang, Qian Ren, Min Ma, Chao Dong, Kenji Hashimoto
OBJECTIVE: Although alterations in the dendritic spine density in the brain regions may play a role in the stress-induced depression-like phenotype, the precise mechanisms are unknown. The aim was to investigate the role of spine density in the brain regions after chronic social defeat stress (CSDS). METHODS: We examined dendritic spine density in the medial prefrontal cortex (mPFC), CA1, CA3, dentate gyrus (DG) of hippocampus, nucleus accumbens (NAc), and ventral tegmental area (VTA) of susceptible and resilient mice after CSDS...
June 1, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28560935/medical-and-psychosocial-determinants-of-risk-of-postpartum-depression-a-cross-sectional-study
#4
Karolina Maliszewska, Mariola Bidzan, Małgorzata Świątkowska-Freund, Krzysztof Preis
OBJECTIVE: The aim of this study was to investigate the degree of risk of maternal postpartum depression during the second month of puerperium. METHOD: In total, 387 postnatal women filled out a questionnaire concerning their health and social status, as well as the following tests: the Edinburgh Postnatal Depression Scale (EPDS), the Patient Health Questionnaire-9 (PHQ-9), the Neo Five-Factor Inventory (NEO-FFI) Personality Inventory and the Berlin Social Support Scales...
May 31, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28535843/validation-of-the-semi-structured-psychotic-depression-assessment-scale-pdas-interview
#5
Rugül Köse Çinar, Søren Dinesen Østergaard
OBJECTIVE: Recently, a semi-structured interview dedicated to aid rating on the Psychotic Depression Assessment Scale (PDAS) was developed. Here, we aimed to validate PDAS ratings collected via this semi-structured interview. METHODS: A total of 50 patients with psychotic depression - 34 with unipolar psychotic depression and 16 with bipolar psychotic depression - were recruited for the study. The following aspects of validity were investigated: clinical validity, psychometric validity (scalability), and responsiveness...
May 24, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28482936/a-comparison-of-immersive-virtual-reality-with-traditional-neuropsychological-measures-in-the-assessment-of-executive-functions
#6
Sophie Melissa Clare Davison, Catherine Deeprose, Sylvia Terbeck
OBJECTIVE: This study investigated immersive virtual reality (IVR), as a novel technique to test executive function of healthy younger and older adults. We predicted IVR tasks to have greater predictive power than traditional measures when assessing age-related cognitive functioning due to the real-world validity of the tasks. METHODS: Participants (n=40) completed the Stroop colour-word test and the trail-making test (TMT) as traditional and commonly used assessments of executive functioning...
May 9, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28478778/investigation-of-serum-levels-of-sortilin-in-response-to-antidepressant-treatment
#7
Henriette Nørmølle Buttenschøn, Marit Nielsen, Simon Glerup, Ole Mors
BACKGROUND: The identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment. METHODS: The study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment...
May 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28473012/circuits-regulating-pleasure-and-happiness-evolution-and-role-in-mental-disorders
#8
Anton J M Loonen, Svetlana A Ivanova
Taking the evolutionary development of the forebrain as a starting point, the authors developed a biological framework for the subcortical regulation of human emotional behaviour which may offer an explanation for the pathogenesis of the principle symptoms of mental disorders. Appetitive-searching (reward-seeking) and distress-avoiding (misery-fleeing) behaviour are essential for all free-moving animals to stay alive and to have offspring. Even the oldest ocean-dwelling animal creatures, living about 560 million years ago and human ancestors, must therefore have been capable of generating these behaviours...
May 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28462732/anaesthesia-for-electroconvulsive-therapy-new-tricks-for-old-drugs-a-systematic-review
#9
Tobias Kvist Stripp, Martin Balslev Jorgensen, Niels Vidiendal Olsen
OBJECTIVE: The objective of this review is to investigate existing literature in order to delineate whether the use of anaesthesia and timing of seizure induction in a new and optimised way may improve the efficacy of electroconvulsive therapy (ECT). METHODS: PubMed/MEDLINE was searched for existing literature, last search on 24 June 2015. Relevant clinical studies on human subjects involving choice of anaesthetic, ventilation and bispectral index (BIS) monitoring in the ECT setting were considered...
May 2, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28485253/abstracts-scandinavian-college-of-neuropsychopharmacology-scnp-58th-annual-meeting-26-28-april-2017-copenhagen-denmark
#10
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28399943/bipolar-disorder-patients-display-reduced-serum-complement-levels-and-elevated-peripheral-blood-complement-expression-levels
#11
Uğur Akcan, Sercan Karabulut, Cem İsmail Küçükali, Sibel Çakır, Erdem Tüzün
OBJECTIVE: Bipolar disorder (BD) patients have recently been shown to exhibit increased proinflammatory cytokine levels indicating the role of inflammation in this disease. As inflammatory responses often include complement level alterations and complement production is influenced by cytokines, we aimed to find out whether complement system is activated in BD in a time-dependent manner and complement factors are involved in BD pathogenesis. METHODS: Serum C4, factor B, sC5b-9 and neuron-specific enolase levels were measured by enzyme-linked immunosorbent assay, whereas peripheral blood mononuclear cell messenger RNA (mRNA) expression levels of C1q, C4, factor B and CD55 were measured by real-time polymerase chain reaction in chronic BD patients (n=22), first episode BD patients (n=24) and healthy controls (n=19)...
April 12, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28393745/correlation-of-reduced-social-communicational-and-interactional-skills-with-regional-grey-matter-volumes-in-schizophrenia-patients
#12
Miho Ota, Junko Matsuo, Noriko Sato, Toshiya Teraishi, Hiroaki Hori, Kotaro Hattori, Yoko Kamio, Hiroshi Kunugi
OBJECTIVE: Recent studies have detected similarities between autism spectrum disorder and schizophrenia. We investigated structural abnormalities associated with autistic-like traits in patients with schizophrenia by voxel-based morphometry. METHODS: Patients with schizophrenia and healthy subjects were evaluated by the adult version of the social responsiveness scale (SRS-A), which is sensitive to autistic traits and symptoms even under subthreshold conditions, and magnetic resonance imaging...
April 10, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28376941/systematic-evaluation-of-skeletal-fractures-caused-by-induction-of-electroconvulsive-seizures-in-rat-state-a-need-for-attention-and-refinement-of-the-procedure
#13
Maria Ekemohn, Marie Kjær Nielsen, Matilda Grahm, Anders Tingström, Birgitte Kousholt, Gregers Wegener, Cecilie Bay-Richter
OBJECTIVE: Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects of ECT. As the treatment itself serves as an instant anaesthetic and anaesthetic agents may affect memory functions and behaviour, ECS is traditionally administered without muscle relaxation and anaesthesia. A major problem of unmodified ECS, which has only been addressed peripherally in the literature, is that some animals sustain spinal fractures and subsequent hind leg paralysis (paraplegia)...
April 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28262083/exercise-works-for-depression-bridging-the-implementation-gap-and-making-exercise-a-core-component-of-treatment
#14
Felipe Barreto Schuch, Ioannis Dimitrios Morres, Panteleimon Ekkekakis, Simon Rosenbaum, Brendon Stubbs
No abstract text is available yet for this article.
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27919302/exercise-and-depression-where-do-we-go-from-here-a-rebuttal-to-schuch-et-al
#15
Fabien David Legrand, Elise Neff
No abstract text is available yet for this article.
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27573591/personality-traits-as-an-endophenotype-in-genetic-studies-on-suicidality-in-bipolar-disorder
#16
J Pawlak, M Dmitrzak-Węglarz, M Maciukiewicz, P Kapelski, P Czerski, A Leszczyńska-Rodziewicz, D Zaremba, J Hauser
Introduction The influence of personality traits on suicidal behaviour risk has been well documented. Personality traits and suicidal behaviour are partially genetically determined and personality has been described as an endophenotype of suicidal behaviour. The aim of this study was to investigate a possible association between personality traits with suicidal behaviour and selected serotonergic gene polymorphisms. METHODS: In the study we included 156 patients meeting DSM-IV criteria for bipolar disorder (BP) and 93 healthy controls...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27514629/a-randomised-controlled-trial-of-adjunctive-yoga-and-adjunctive-physical-exercise-training-for-cognitive-dysfunction-in-schizophrenia
#17
RANDOMIZED CONTROLLED TRIAL
Triptish Bhatia, Sati Mazumdar, Joel Wood, Fanyin He, Raquel E Gur, Ruben C Gur, Vishwajit L Nimgaonkar, Smita N Deshpande
BACKGROUND: Yoga and physical exercise have been used as adjunctive intervention for cognitive dysfunction in schizophrenia (SZ), but controlled comparisons are lacking. Aims A single-blind randomised controlled trial was designed to evaluate whether yoga training or physical exercise training enhance cognitive functions in SZ, based on a prior pilot study. METHODS: Consenting, clinically stable, adult outpatients with SZ (n=286) completed baseline assessments and were randomised to treatment as usual (TAU), supervised yoga training with TAU (YT) or supervised physical exercise training with TAU (PE)...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27502527/delirium-in-elderly-patients-association-with-educational-attainment
#18
Sónia Martins, José Artur Paiva, Mário R Simões, Lia Fernandes
OBJECTIVE: Among cognitive reserve markers, educational attainment is the most widely studied, with several studies establishing a strong association with risk of dementia. However, it has not yet been fully examined in delirium. This study aims to analyse the relationship between educational attainment and delirium. METHODS: The study included elderly hospitalised patients admitted (≥48 h) into an intermediate care unit (IMCU) of Intensive Care Medicine Service...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27460766/association-of-nkapl-tspan18-and-mpc2-gene-variants-with-schizophrenia-based-on-new-data-and-a-meta-analysis-in-han-chinese
#19
Zhen Li, Tingting Shen, Ran Xin, Baoyun Liang, Juan Jiang, Weijun Ling, Bo Wei, Li Su
BACKGROUND: Schizophrenia (SZ) is suggested to be a complex polygenetic disorder with high heritability. Genome-wide association studies have found that the rs1635, rs11038167, and rs10489202 polymorphisms are associated with SZ in Han Chinese. However, results of validation studies are inconsistent. This study aimed to test the association between the NKAPL rs1635, TSPAN18 rs11038167, and MPC2 rs10489202 polymorphisms and SZ in a Chinese population. METHODS: This study contained 700 unrelated SZ patients (300 Zhuang and 400 Han) and 700 gender- and age-matched controls (300 Zhuang and 400 Han)...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27412497/increased-serum-g72-protein-levels-in-patients-with-schizophrenia-a-potential-candidate-biomarker
#20
Esra Soydaş Akyol, Yakup Albayrak, Nurkan Aksoy, Başak Şahin, Murat Beyazyüz, Murat Kuloğlu, Kenji Hashimoto
OBJECTIVE: The product of the G72 gene is an activator of d-amino acid oxidase and has been suggested to play a role in the pathogenesis of schizophrenia. Increased G72 protein levels may be associated with disturbed glutamatergic transmission and increased reactive oxygen species. Only one pilot study by Lin et al. has investigated the potential role of serum G72 protein levels as a biomarker for schizophrenia. In this study, we aimed to compare serum G72 protein levels between patients with schizophrenia and healthy controls, and to retest the results of the previous pilot study...
April 2017: Acta Neuropsychiatrica
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