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Acta Neuropsychiatrica

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https://www.readbyqxmd.com/read/30008280/mediator-effects-of-parameters-of-inflammation-and-neurogenesis-from-a-n-acetyl-cysteine-clinical-trial-for-bipolar-depression
#1
Bruna Panizzutti, Chiara Bortolasci, Kyoko Hasebe, Srisaiyini Kidnapillai, Laura Gray, Ken Walder, Michael Berk, Mohammadreza Mohebbi, Seetal Dodd, Clarissa Gama, Pedro V Magalhães, Susan M Cotton, Flávio Kapczinski, Ashley I Bush, Gin S Malhi, Olivia M Dean
OBJECTIVE: This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression. METHODS: This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers...
July 16, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29909818/individual-responses-of-rodents-in-modelling-of-affective-disorders-and-in-their-treatment-prospective-review
#2
Haim Einat, Itamar Ezer, Nirit Z Kara, Catherine Belzung
IntroductionLack of good animal models for affective disorders, including major depression and bipolar disorder, is noted as a major bottleneck in attempts to study these disorders and develop better treatments. We suggest that an important approach that can help in the development and use of better models is attention to variability between model animals. RESULTS: Differences between mice strains were studied for some decades now, and sex differences get more attention than in the past...
June 18, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29880069/effects-of-erythropoietin-on-body-composition-and-fat-glucose-metabolism-in-patients-with-affective-disorders
#3
Maj Vinberg, Pernille Højman, Bente Klarlund Pedersen, Lars Vedel Kessing, Kamilla W Miskowiak
BACKGROUND: Erythropoietin (EPO) has been suggested to improve metabolism and also cognition, but human studies are scarce. This randomised controlled trial aimed to investigate whether EPO treatment influences body composition and fat and glycated haemoglobin (HbA1c) and fasting glucose, and whether these changes would be associated with previous observed cognitive benefits of EPO. METHOD: In total, 84 non-obese patients with treatment-resistant unipolar depression or bipolar disorder in remission were randomised to 8 weekly EPO (40,000 IU) or saline (NaCl 0...
June 8, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29764526/cannabinoid-signalling-in-embryonic-and-adult-neurogenesis-possible-implications-for-psychiatric-and-neurological-disorders
#4
Rúbia W de Oliveira, Cilene L Oliveira, Francisco S Guimarães, Alline C Campos
Cannabinoid signalling modulates several aspects of brain function, including the generation and survival of neurons during embryonic and adult periods. The present review intended to summarise evidence supporting a role for the endocannabinoid system on the control of neurogenesis and neurogenesis-dependent functions. Studies reporting participation of cannabinoids on the regulation of any step of neurogenesis and the effects of cannabinoid compounds on animal models possessing neurogenesis-dependent features were selected from Medline...
May 16, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29911523/the-psychotic-depression-assessment-scale-pdas-in-measurement-based-care-of-patients-with-psychotic-depression
#5
Per Bech
No abstract text is available yet for this article.
June 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29759094/abstracts-scandinavian-college-of-neuropsychopharmacology-scnp-59th-annual-meeting-11-13-april-2018-aarhus-denmark
#6
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29208055/combinations-of-snp-genotypes-from-the-wellcome-trust-case-control-study-of-bipolar-patients
#7
Erling Mellerup, Martin Balslev Jørgensen, Henrik Dam, Gert Lykke Møller
OBJECTIVES: Combinations of genetic variants are the basis for polygenic disorders. We examined combinations of SNP genotypes taken from the 446 729 SNPs in The Wellcome Trust Case Control Study of bipolar patients. METHODS: Parallel computing by graphics processing units, cloud computing, and data mining tools were used to scan The Wellcome Trust data set for combinations. RESULTS: Two clusters of combinations were significantly associated with bipolar disorder...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29183417/neurological-soft-signs-significantly-differentiate-schizophrenia-patients-from-healthy-controls
#8
Konstantinos N Fountoulakis, Panagiotis Panagiotidis, Xenia Gonda, Vasilios Kimiskidis, Ioannis Nimatoudis
OBJECTIVE: Neurological soft signs (NSS) are a group of minor non-localisable neurological abnormalities found more often in patients with schizophrenia. The aim of the current study was to test for the effect of gender, age, parental age, age at onset and clinical symptomatology on NSS.Material and methodsThe study sample included 133 patients suffering from schizophrenia according to DSM-IV-TR (77 males and 56 females; aged 33.55±11.22 years old) and 122 normal controls (66 males and 56 females; aged 32...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28714423/distinctive-neuropsychological-profiles-differentiate-patients-with-functional-memory-disorder-from-patients-with-amnestic-mild-cognitive-impairment
#9
Sarah J Wakefield, Daniel J Blackburn, Kirsty Harkness, Aijaz Khan, Markus Reuber, Annalena Venneri
OBJECTIVES: Patients with functional memory disorder (FMD) report significant memory failures in everyday life. Differentiating these patients from those with memory difficulties due to early stage neurodegenerative conditions is clinically challenging. The current study explored whether distinctive neuropsychological profiles could be established, suitable to differentiate patients with FMD from healthy individuals and those experiencing amnestic mild cognitive impairment (a-MCI). METHODS: Patients with a clinical diagnosis of FMD were compared with patients with a-MCI, and healthy matched controls on several tests assessing different cognitive functions...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28566105/regional-differences-in-dendritic-spine-density-confer-resilience-to-chronic-social-defeat-stress
#10
Youge Qu, Chun Yang, Qian Ren, Min Ma, Chao Dong, Kenji Hashimoto
OBJECTIVE: Although alterations in the dendritic spine density in the brain regions may play a role in the stress-induced depression-like phenotype, the precise mechanisms are unknown. The aim was to investigate the role of spine density in the brain regions after chronic social defeat stress (CSDS). METHODS: We examined dendritic spine density in the medial prefrontal cortex (mPFC), CA1, CA3, dentate gyrus (DG) of hippocampus, nucleus accumbens (NAc), and ventral tegmental area (VTA) of susceptible and resilient mice after CSDS...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28482936/a-comparison-of-immersive-virtual-reality-with-traditional-neuropsychological-measures-in-the-assessment-of-executive-functions
#11
Sophie Melissa Clare Davison, Catherine Deeprose, Sylvia Terbeck
OBJECTIVE: This study investigated immersive virtual reality (IVR), as a novel technique to test executive function of healthy younger and older adults. We predicted IVR tasks to have greater predictive power than traditional measures when assessing age-related cognitive functioning due to the real-world validity of the tasks. METHODS: Participants (n=40) completed the Stroop colour-word test and the trail-making test (TMT) as traditional and commonly used assessments of executive functioning...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28478778/investigation-of-serum-levels-of-sortilin-in-response-to-antidepressant-treatment
#12
Henriette Nørmølle Buttenschøn, Marit Nielsen, Simon Glerup, Ole Mors
BACKGROUND: The identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment. METHODS: The study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28462732/anaesthesia-for-electroconvulsive-therapy-new-tricks-for-old-drugs-a-systematic-review
#13
Tobias Kvist Stripp, Martin Balslev Jorgensen, Niels Vidiendal Olsen
OBJECTIVE: The objective of this review is to investigate existing literature in order to delineate whether the use of anaesthesia and timing of seizure induction in a new and optimised way may improve the efficacy of electroconvulsive therapy (ECT). METHODS: PubMed/MEDLINE was searched for existing literature, last search on 24 June 2015. Relevant clinical studies on human subjects involving choice of anaesthetic, ventilation and bispectral index (BIS) monitoring in the ECT setting were considered...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28399943/bipolar-disorder-patients-display-reduced-serum-complement-levels-and-elevated-peripheral-blood-complement-expression-levels
#14
Uğur Akcan, Sercan Karabulut, Cem İsmail Küçükali, Sibel Çakır, Erdem Tüzün
OBJECTIVE: Bipolar disorder (BD) patients have recently been shown to exhibit increased proinflammatory cytokine levels indicating the role of inflammation in this disease. As inflammatory responses often include complement level alterations and complement production is influenced by cytokines, we aimed to find out whether complement system is activated in BD in a time-dependent manner and complement factors are involved in BD pathogenesis. METHODS: Serum C4, factor B, sC5b-9 and neuron-specific enolase levels were measured by enzyme-linked immunosorbent assay, whereas peripheral blood mononuclear cell messenger RNA (mRNA) expression levels of C1q, C4, factor B and CD55 were measured by real-time polymerase chain reaction in chronic BD patients (n=22), first episode BD patients (n=24) and healthy controls (n=19)...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29565002/quality-of-life-among-parents-of-south-african-children-with-autism-spectrum-disorder
#15
Ayman Alhazmi, Reneva Petersen, Kirsten A Donald
OBJECTIVE: To describe the quality of life (QOL) of South African parents caring for children with autism spectrum disorder (ASD) as compared with parents of typically developing (TD) children from the same community. METHODS: A cross-sectional study was done evaluating the QOL of parents of 52 children (26 parents of children with ASD versus 26 parents of TD children) using a structured measure, (World Health Organization Quality of Life Assessment-BREF). RESULTS: The mean age of the children with ASD was 64...
March 22, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29564992/the-neuropathological-study-of-myelin-oligodendrocyte-glycoprotein-in-the-temporal-lobe-of-schizophrenia-patients
#16
Tomoyasu Marui, Youta Torii, Shuji Iritani, Hirotaka Sekiguchi, Chikako Habuchi, Hiroshige Fujishiro, Kenichi Oshima, Kazuhiro Niizato, Shotaro Hayashida, Katsuhisa Masaki, Junichi Kira, Norio Ozaki
OBJECTIVE: Recent studies based on the neuroimaging analysis, genomic analysis and transcriptome analysis of the postmortem brain suggest that the pathogenesis of schizophrenia is related to myelin-oligodendrocyte abnormalities. However, no serious neuropathological investigation of this protein in the schizophrenic brain has yet been performed. In this study, to confirm the change in neuropathological findings due to the pathogenesis of this disease, we observed the expression of myelin-oligodendrocyte directly in the brain tissue of schizophrenia patients...
March 22, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29559020/gene-polymorphisms-and-response-to-transcranial-direct-current-stimulation-for-auditory-verbal-hallucinations-in-schizophrenia
#17
Harleen Chhabra, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anushree Bose, Sri Mahavir Agarwal, Vanteemar S Sreeraj, Damodharan Dinakaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
OBJECTIVE: Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia. METHODS: Schizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS...
March 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29559016/differential-plastic-changes-in-synthesis-and-binding-in-the-mouse-somatostatin-system-after-electroconvulsive-stimulation
#18
Mikkel Vestergaard Olesen, Casper René Gøtzsche, Søren Hofman Christiansen, David Paul Drucker Woldbye
OBJECTIVE: Electroconvulsive therapy (ECT) is regularly used to treat patients with severe major depression, but the mechanisms underlying the beneficial effects remain uncertain. Electroconvulsive stimulation (ECS) regulates diverse neurotransmitter systems and induces anticonvulsant effects, properties implicated in mediating therapeutic effects of ECT. Somatostatin (SST) is a candidate for mediating these effects because it is upregulated by ECS and exerts seizure-suppressant effects...
March 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29530104/the-association-between-school-exam-grades-and-subsequent-development-of-bipolar-disorder
#19
Steffie Damgaard Pedersen, Søren Dinesen Østergaard, Liselotte Petersen
OBJECTIVE: Prior studies have indicated that both high and low school grades are associated with development of bipolar disorder (BD), but these studies have not adjusted for parental history of mental disorder, which is a likely confounder. Furthermore, the association between school grades and bipolar I disorder (BD-I) has not been studied. Therefore, we aimed to study the association between school exam grades and subsequent development of BD and BD-I while adjusting for parental history of mental disorder...
March 13, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29501075/clinical-validation-of-the-psychotic-depression-assessment-scale-pdas-against-independent-global-severity-ratings-in-older-adults
#20
Tom Vermeulen, Lieve Lemey, Linda Van Diermen, Didier Schrijvers, Yamina Madani, Bernard Sabbe, Maarten J A Van Den Bossche, Roos C van der Mast, Søren D Østergaard
OBJECTIVES: According to a recent study, ratings on the Psychotic Depression Assessment Scale (PDAS) obtained via a dedicated semi-structured interview are valid measures of the severity of psychotic depression. This study aimed to further test the validity, scalability and responsiveness of the PDAS in older adults using independent ratings on the Clinical Global Impression Scale - Severity (CGI-S) and the Montgomery-Asberg Depression Rating Scale (MADRS) as references. METHODS: Ratings were performed at admission and discharge at two old age psychiatric wards in Flanders, Belgium...
March 4, 2018: Acta Neuropsychiatrica
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