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Acta Neuropsychiatrica

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https://www.readbyqxmd.com/read/28399943/bipolar-disorder-patients-display-reduced-serum-complement-levels-and-elevated-peripheral-blood-complement-expression-levels
#1
Uğur Akcan, Sercan Karabulut, Cem İsmail Küçükali, Sibel Çakır, Erdem Tüzün
OBJECTIVE: Bipolar disorder (BD) patients have recently been shown to exhibit increased proinflammatory cytokine levels indicating the role of inflammation in this disease. As inflammatory responses often include complement level alterations and complement production is influenced by cytokines, we aimed to find out whether complement system is activated in BD in a time-dependent manner and complement factors are involved in BD pathogenesis. METHODS: Serum C4, factor B, sC5b-9 and neuron-specific enolase levels were measured by enzyme-linked immunosorbent assay, whereas peripheral blood mononuclear cell messenger RNA (mRNA) expression levels of C1q, C4, factor B and CD55 were measured by real-time polymerase chain reaction in chronic BD patients (n=22), first episode BD patients (n=24) and healthy controls (n=19)...
April 12, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28393745/correlation-of-reduced-social-communicational-and-interactional-skills-with-regional-grey-matter-volumes-in-schizophrenia-patients
#2
Miho Ota, Junko Matsuo, Noriko Sato, Toshiya Teraishi, Hiroaki Hori, Kotaro Hattori, Yoko Kamio, Hiroshi Kunugi
OBJECTIVE: Recent studies have detected similarities between autism spectrum disorder and schizophrenia. We investigated structural abnormalities associated with autistic-like traits in patients with schizophrenia by voxel-based morphometry. METHODS: Patients with schizophrenia and healthy subjects were evaluated by the adult version of the social responsiveness scale (SRS-A), which is sensitive to autistic traits and symptoms even under subthreshold conditions, and magnetic resonance imaging...
April 10, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28376941/systematic-evaluation-of-skeletal-fractures-caused-by-induction-of-electroconvulsive-seizures-in-rat-state-a-need-for-attention-and-refinement-of-the-procedure
#3
Maria Ekemohn, Marie Kjær Nielsen, Matilda Grahm, Anders Tingström, Birgitte Kousholt, Gregers Wegener, Cecilie Bay-Richter
OBJECTIVE: Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects of ECT. As the treatment itself serves as an instant anaesthetic and anaesthetic agents may affect memory functions and behaviour, ECS is traditionally administered without muscle relaxation and anaesthesia. A major problem of unmodified ECS, which has only been addressed peripherally in the literature, is that some animals sustain spinal fractures and subsequent hind leg paralysis (paraplegia)...
April 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28345494/adaptation-and-validation-of-the-alzheimer-s-disease-assessment-scale-cognitive-adas-cog-in-a-low-literacy-setting-in-sub-saharan-africa
#4
Stella-Maria Paddick, Aloyce Kisoli, Sarah Mkenda, Godfrey Mbowe, William Keith Gray, Catherine Dotchin, Adesola Ogunniyi, John Kisima, Olaide Olakehinde, Declare Mushi, Richard William Walker
OBJECTIVE: This study aimed to assess the feasibility of a low-literacy adaptation of the Alzheimer's Disease Assessment Scale - Cognitive (ADAS-Cog) for use in rural sub-Saharan Africa (SSA) for interventional studies in dementia. No such adaptations currently exist. METHODS: Tanzanian and Nigerian health professionals adapted the ADAS-Cog by consensus. Validation took place in a cross-sectional sample of 34 rural-dwelling older adults with mild/moderate dementia alongside 32 non-demented controls in Tanzania...
March 27, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28343466/treatment-of-gambling-disorder-patients-with-comorbid-depression
#5
Jakob Linnet, Monique Jeppsen Mensink, Johanne de Neergaard Bonde, Michael Winterdahl
OBJECTIVE: This study was conducted to investigate and clinically assess comorbid depression and its relevance in individuals suffering from gambling disorders. The DSM-V defines the condition of gambling disorder as a persistent and recurrent problematic gambling behaviour leading to clinically significant impairment or distress. METHOD: A total of 61 subjects with gambling disorders were assessed using the Structured Clinical Interview for the DSM-IV (SCID-I), the South Oaks Gambling Screen (SOGS) and the Major Depression inventory (MDI)...
March 27, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28318471/adjunctive-n-acetylcysteine-in-depression-exploration-of-interleukin-6-c-reactive-protein-and-brain-derived-neurotrophic-factor
#6
Kyoko Hasebe, Laura Gray, Chiara Bortolasci, Bruna Panizzutti, Mohammadreza Mohebbi, Srisaiyini Kidnapillai, Briana Spolding, Ken Walder, Michael Berk, Gin Malhi, Seetal Dodd, Olivia M Dean
OBJECTIVE: This study aimed to explore effects of adjunctive N-acetylcysteine (NAC) treatment on inflammatory and neurogenesis markers in unipolar depression. METHODS: We embarked on a 12-week clinical trial of NAC (2000 mg/day compared with placebo) as an adjunctive treatment for unipolar depression. A follow-up visit was conducted 4 weeks following the completion of treatment. We collected serum samples at baseline and the end of the treatment phase (week 12) to determine changes in interleukin-6 (IL6), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following NAC treatment...
March 20, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28270247/gut-brain-actions-underlying-comorbid-anxiety-and-depression-associated-with-inflammatory-bowel-disease
#7
Áine Abautret-Daly, Elaine Dempsey, Adolfo Parra-Blanco, Carlos Medina, Andrew Harkin
Introduction Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD...
March 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28262083/exercise-works-for-depression-bridging-the-implementation-gap-and-making-exercise-a-core-component-of-treatment
#8
Felipe Barreto Schuch, Ioannis Dimitrios Morres, Panteleimon Ekkekakis, Simon Rosenbaum, Brendon Stubbs
No abstract text is available yet for this article.
March 6, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28245891/do-not-blame-the-ssris-blame-the-hamilton-depression-rating-scale
#9
Søren Dinesen Østergaard
No abstract text is available yet for this article.
March 1, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27573591/personality-traits-as-an-endophenotype-in-genetic-studies-on-suicidality-in-bipolar-disorder
#10
J Pawlak, M Dmitrzak-Węglarz, M Maciukiewicz, P Kapelski, P Czerski, A Leszczyńska-Rodziewicz, D Zaremba, J Hauser
Introduction The influence of personality traits on suicidal behaviour risk has been well documented. Personality traits and suicidal behaviour are partially genetically determined and personality has been described as an endophenotype of suicidal behaviour. The aim of this study was to investigate a possible association between personality traits with suicidal behaviour and selected serotonergic gene polymorphisms. METHODS: In the study we included 156 patients meeting DSM-IV criteria for bipolar disorder (BP) and 93 healthy controls...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27514629/a-randomised-controlled-trial-of-adjunctive-yoga-and-adjunctive-physical-exercise-training-for-cognitive-dysfunction-in-schizophrenia
#11
RANDOMIZED CONTROLLED TRIAL
Triptish Bhatia, Sati Mazumdar, Joel Wood, Fanyin He, Raquel E Gur, Ruben C Gur, Vishwajit L Nimgaonkar, Smita N Deshpande
BACKGROUND: Yoga and physical exercise have been used as adjunctive intervention for cognitive dysfunction in schizophrenia (SZ), but controlled comparisons are lacking. Aims A single-blind randomised controlled trial was designed to evaluate whether yoga training or physical exercise training enhance cognitive functions in SZ, based on a prior pilot study. METHODS: Consenting, clinically stable, adult outpatients with SZ (n=286) completed baseline assessments and were randomised to treatment as usual (TAU), supervised yoga training with TAU (YT) or supervised physical exercise training with TAU (PE)...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27502527/delirium-in-elderly-patients-association-with-educational-attainment
#12
Sónia Martins, José Artur Paiva, Mário R Simões, Lia Fernandes
OBJECTIVE: Among cognitive reserve markers, educational attainment is the most widely studied, with several studies establishing a strong association with risk of dementia. However, it has not yet been fully examined in delirium. This study aims to analyse the relationship between educational attainment and delirium. METHODS: The study included elderly hospitalised patients admitted (≥48 h) into an intermediate care unit (IMCU) of Intensive Care Medicine Service...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27460766/association-of-nkapl-tspan18-and-mpc2-gene-variants-with-schizophrenia-based-on-new-data-and-a-meta-analysis-in-han-chinese
#13
Zhen Li, Tingting Shen, Ran Xin, Baoyun Liang, Juan Jiang, Weijun Ling, Bo Wei, Li Su
BACKGROUND: Schizophrenia (SZ) is suggested to be a complex polygenetic disorder with high heritability. Genome-wide association studies have found that the rs1635, rs11038167, and rs10489202 polymorphisms are associated with SZ in Han Chinese. However, results of validation studies are inconsistent. This study aimed to test the association between the NKAPL rs1635, TSPAN18 rs11038167, and MPC2 rs10489202 polymorphisms and SZ in a Chinese population. METHODS: This study contained 700 unrelated SZ patients (300 Zhuang and 400 Han) and 700 gender- and age-matched controls (300 Zhuang and 400 Han)...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27412497/increased-serum-g72-protein-levels-in-patients-with-schizophrenia-a-potential-candidate-biomarker
#14
Esra Soydaş Akyol, Yakup Albayrak, Nurkan Aksoy, Başak Şahin, Murat Beyazyüz, Murat Kuloğlu, Kenji Hashimoto
OBJECTIVE: The product of the G72 gene is an activator of d-amino acid oxidase and has been suggested to play a role in the pathogenesis of schizophrenia. Increased G72 protein levels may be associated with disturbed glutamatergic transmission and increased reactive oxygen species. Only one pilot study by Lin et al. has investigated the potential role of serum G72 protein levels as a biomarker for schizophrenia. In this study, we aimed to compare serum G72 protein levels between patients with schizophrenia and healthy controls, and to retest the results of the previous pilot study...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27396868/effects-of-chronic-l-theanine-administration-in-patients-with-major-depressive-disorder-an-open-label-study
#15
Shinsuke Hidese, Miho Ota, Chisato Wakabayashi, Takamasa Noda, Hayato Ozawa, Tsutomu Okubo, Hiroshi Kunugi
OBJECTIVE: l-theanine, an amino acid uniquely contained in green tea (Camellia sinensis), has been suggested to have various psychotropic effects. This study aimed to examine whether l-theanine is effective for patients with major depressive disorder (MDD) in an open-label clinical trial. METHODS: Subjects were 20 patients with MDD (four males; mean age: 41.0±14.1 years, 16 females; 42.9±12.0 years). l-theanine (250 mg/day) was added to the current medication of each participant for 8 weeks...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27145824/a-critical-review-of-exercise-as-a-treatment-for-clinically-depressed-adults-time-to-get-pragmatic
#16
REVIEW
Felipe Barreto Schuch, Ioannis Dimitrios Morres, Panteleimon Ekkekakis, Simon Rosenbaum, Brendon Stubbs
OBJECTIVE: Although considerable evidence supports the efficacy of exercise as an antidepressant treatment, critical reviews informing routine practice and future research directions are scarce. METHODS: We critically reviewed exercise studies for clinically depressed adults, focussing on the PICOS criteria referred to participants, interventions, comparisons, outcomes, and study designs. RESULTS: Most studies have not screened their samples for symptom heterogeneity...
April 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27725006/visuospatial-memory-improvement-in-patients-with-diffuse-axonal-injury-dai-a-1-year-follow-up-study
#17
Ana Luiza Zaninotto, Jessica Elias Vicentini, Davi Jorge Fontoura Solla, Tatiana Tateishi Silva, Vinicius Monteiro de Paula Guirado, Fabrício Feltrin, Mara Cristina Souza de Lucia, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
OBJECTIVE: Diffuse axonal injury (DAI) is prevalent in traumatic brain injury (TBI), and is often associated with poor outcomes and cognitive impairment, including memory deficits. Few studies have explored visual memory after TBI and its relationship to executive functioning. Executive functioning is crucial for remembering an object's location, operating devices, driving, and route finding. We compared visual memory performance via the Rey-Osterrieth Complex Figure (ROCF) test 6 and 12 months after DAI...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27692004/inflammatory-aspects-of-epileptogenesis-contribution-of-molecular-inflammatory-mechanisms
#18
REVIEW
Feyza Alyu, Miriş Dikmen
OBJECTIVE: Epilepsy is a chronic neurological disease characterised with seizures. The aetiology of the most generalised epilepsies cannot be explicitly determined and the seizures are pronounced to be genetically determined by disturbances of receptors in central nervous system. Besides, neurotransmitter distributions or other metabolic problems are supposed to involve in epileptogenesis. Lack of adequate data about pharmacological agents that have antiepileptogenic effects point to need of research on this field...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27406788/decreased-levels-of-kynurenic-acid-in-prefrontal-cortex-in-a-genetic-animal-model-of-depression
#19
Xi-Cong Liu, Sophie Erhardt, Michel Goiny, Göran Engberg, Aleksander A Mathé
OBJECTIVE: There is a growing interest in the role of kynurenine pathway and tryptophan metabolites in the pathophysiology of depression. In the present study, the metabolism of tryptophan along the kynurenine pathway was analysed in a rat model of depression. METHODS: Kynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK) were measured by high-performance liquid chromatography (HPLC) in prefrontal cortex (PFC) and frontal cortex (FC) in a rat model of depression, the Flinders Sensitive Line (FSL) and their controls, the Flinders Resistant Line (FRL) rats...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27387606/serotonin-and-poor-neonatal-adaptation-after-antidepressant-exposure-in-utero
#20
Noera Kieviet, Vera van Keulen, Peter Marinus van de Ven, Koert Melchior Dolman, Martine Deckers, Adriaan Honig
OBJECTIVE: Infants exposed to selective antidepressants (SADs) in utero are at risk to develop poor neonatal adaptation (PNA) postpartum. As symptoms are non-specific and the aetiology of PNA is unknown, the diagnostic process is hampered. We hypothesised that the serotonin metabolism plays a role in the aetiology of PNA. METHODS: In this controlled study, infants admitted postpartum from February 2012 to August 2013 were included and followed for 3 days. Infants exposed to SADs during at least the last 2 weeks of fetal life were included in the patient group (n=63)...
February 2017: Acta Neuropsychiatrica
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