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Acta Neuropsychiatrica

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https://www.readbyqxmd.com/read/29764526/cannabinoid-signalling-in-embryonic-and-adult-neurogenesis-possible-implications-for-psychiatric-and-neurological-disorders
#1
Rúbia W de Oliveira, Cilene L Oliveira, Francisco S Guimarães, Alline C Campos
Cannabinoid signalling modulates several aspects of brain function, including the generation and survival of neurons during embryonic and adult periods. The present review intended to summarise evidence supporting a role for the endocannabinoid system on the control of neurogenesis and neurogenesis-dependent functions. Studies reporting participation of cannabinoids on the regulation of any step of neurogenesis and the effects of cannabinoid compounds on animal models possessing neurogenesis-dependent features were selected from Medline...
May 16, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29565002/quality-of-life-among-parents-of-south-african-children-with-autism-spectrum-disorder
#2
Ayman Alhazmi, Reneva Petersen, Kirsten A Donald
OBJECTIVE: To describe the quality of life (QOL) of South African parents caring for children with autism spectrum disorder (ASD) as compared with parents of typically developing (TD) children from the same community. METHODS: A cross-sectional study was done evaluating the QOL of parents of 52 children (26 parents of children with ASD versus 26 parents of TD children) using a structured measure, (World Health Organization Quality of Life Assessment-BREF). RESULTS: The mean age of the children with ASD was 64...
March 22, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29564992/the-neuropathological-study-of-myelin-oligodendrocyte-glycoprotein-in-the-temporal-lobe-of-schizophrenia-patients
#3
Tomoyasu Marui, Youta Torii, Shuji Iritani, Hirotaka Sekiguchi, Chikako Habuchi, Hiroshige Fujishiro, Kenichi Oshima, Kazuhiro Niizato, Shotaro Hayashida, Katsuhisa Masaki, Junichi Kira, Norio Ozaki
OBJECTIVE: Recent studies based on the neuroimaging analysis, genomic analysis and transcriptome analysis of the postmortem brain suggest that the pathogenesis of schizophrenia is related to myelin-oligodendrocyte abnormalities. However, no serious neuropathological investigation of this protein in the schizophrenic brain has yet been performed. In this study, to confirm the change in neuropathological findings due to the pathogenesis of this disease, we observed the expression of myelin-oligodendrocyte directly in the brain tissue of schizophrenia patients...
March 22, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29559020/gene-polymorphisms-and-response-to-transcranial-direct-current-stimulation-for-auditory-verbal-hallucinations-in-schizophrenia
#4
Harleen Chhabra, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anushree Bose, Sri Mahavir Agarwal, Vanteemar S Sreeraj, Damodharan Dinakaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
OBJECTIVE: Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia. METHODS: Schizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS...
March 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29559016/differential-plastic-changes-in-synthesis-and-binding-in-the-mouse-somatostatin-system-after-electroconvulsive-stimulation
#5
Mikkel Vestergaard Olesen, Casper René Gøtzsche, Søren Hofman Christiansen, David Paul Drucker Woldbye
OBJECTIVE: Electroconvulsive therapy (ECT) is regularly used to treat patients with severe major depression, but the mechanisms underlying the beneficial effects remain uncertain. Electroconvulsive stimulation (ECS) regulates diverse neurotransmitter systems and induces anticonvulsant effects, properties implicated in mediating therapeutic effects of ECT. Somatostatin (SST) is a candidate for mediating these effects because it is upregulated by ECS and exerts seizure-suppressant effects...
March 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29530104/the-association-between-school-exam-grades-and-subsequent-development-of-bipolar-disorder
#6
Steffie Damgaard Pedersen, Søren Dinesen Østergaard, Liselotte Petersen
OBJECTIVE: Prior studies have indicated that both high and low school grades are associated with development of bipolar disorder (BD), but these studies have not adjusted for parental history of mental disorder, which is a likely confounder. Furthermore, the association between school grades and bipolar I disorder (BD-I) has not been studied. Therefore, we aimed to study the association between school exam grades and subsequent development of BD and BD-I while adjusting for parental history of mental disorder...
March 13, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29501075/clinical-validation-of-the-psychotic-depression-assessment-scale-pdas-against-independent-global-severity-ratings-in-older-adults
#7
Tom Vermeulen, Lieve Lemey, Linda Van Diermen, Didier Schrijvers, Yamina Madani, Bernard Sabbe, Maarten J A Van Den Bossche, Roos C van der Mast, Søren D Østergaard
OBJECTIVES: According to a recent study, ratings on the Psychotic Depression Assessment Scale (PDAS) obtained via a dedicated semi-structured interview are valid measures of the severity of psychotic depression. This study aimed to further test the validity, scalability and responsiveness of the PDAS in older adults using independent ratings on the Clinical Global Impression Scale - Severity (CGI-S) and the Montgomery-Asberg Depression Rating Scale (MADRS) as references. METHODS: Ratings were performed at admission and discharge at two old age psychiatric wards in Flanders, Belgium...
March 4, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29759094/abstracts-scandinavian-college-of-neuropsychopharmacology-scnp-59th-annual-meeting-11-13-april-2018-aarhus-denmark
#8
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29183417/neurological-soft-signs-significantly-differentiate-schizophrenia-patients-from-healthy-controls
#9
Konstantinos N Fountoulakis, Panagiotis Panagiotidis, Xenia Gonda, Vasilios Kimiskidis, Ioannis Nimatoudis
OBJECTIVE: Neurological soft signs (NSS) are a group of minor non-localisable neurological abnormalities found more often in patients with schizophrenia. The aim of the current study was to test for the effect of gender, age, parental age, age at onset and clinical symptomatology on NSS.Material and methodsThe study sample included 133 patients suffering from schizophrenia according to DSM-IV-TR (77 males and 56 females; aged 33.55±11.22 years old) and 122 normal controls (66 males and 56 females; aged 32...
April 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29465026/great-boast-small-roast-on-effects-of-selective-serotonin-reuptake-inhibitors-response-to-a-critique-of-our-systematic-review
#10
Kiran Kumar Katakam, Naqash Javaid Sethi, Janus Christian Jakobsen, Christian Gluud
Our systematic review in BMC Psychiatry concluded that selective serotonin reuptake inhibitors (SSRIs) compared with placebo significantly increase the risk of serious adverse events (SAEs) in patients with major depression and the potential beneficial effects of SSRIs seem to be outweighed by the harms. Hieronymus et al. accused us of methodological inaccuracies and blatant errors. In their post-hoc analysis of our data, they reported that SSRIs only increase the risk of SAEs in elderly and seems safe for non-elderly patients...
February 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29409548/a-clinimetric-analysis-of-a-bprs-6-scale-for-schizophrenia-severity
#11
Per Bech, Stephen F Austin, Nina Timmerby, Thomas A Ban, Stine Bjerrum Møller
OBJECTIVE: A restricted Brief Psychiatric Rating Scale (BPRS-6) with the six schizophrenia specific items from the Positive and Negative Syndrome Scale (PANSS) has been investigated. These six items from the PANSS have recently been found to have both clinical validity and 'unidimensionality' in measuring the severity of schizophrenic states. The primary objective of this study was to evaluate the clinical validity of the BPRS-6. The secondary objective was to evaluate the 'unidimensionality' of the BPRS-6 by an 'item response theory' model...
February 7, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29388517/a-brief-history-of-antidepressant-drug-development-from-tricyclics-to-beyond-ketamine
#12
Vitor Silva Pereira, Vinícius Antonio Hiroaki-Sato
OBJECTIVE: Although monoaminergic-targeted drugs have prompted great advances in the development of treatments for depression, the need for new options persists, since these drugs still have a delayed clinical effect and most patients do not respond properly to them. Recently, the observation of the antidepressant effects of ketamine brought on a new wave of studies regarding the comprehension of the neurobiology of depression and the development of new and more effective antidepressant drugs...
February 1, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28112061/inflammation-and-depression-a-causal-or-coincidental-link-to-the-pathophysiology
#13
Brian E Leonard
This review summarises the evidence that chronic low grade inflammation triggers changes that contribute to the mental and physical ill health of patients with major depression. Inflammation, and the activation of the hypothalamic pituitary axis by stress, are normal components of the stress response but when stress is prolonged and the endocrine and immune system become chronic resulting in the activation of the peripheral macrophages, the central microglia and hypercortisolemia, the neuronal networks are damaged and become dysfunctional...
February 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29310728/bdnf-and-nrg1-polymorphisms-and-temperament-in-selective-serotonin-reuptake-inhibitor-treated-patients-with-major-depression
#14
Kadri Andre, Olli Kampman, Merja Viikki, Eija Setälä-Soikkeli, Ari Illi, Nina Mononen, Terho Lehtimäki, Esa Leinonen
OBJECTIVE: We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks. METHODS: The study population consisted of 98 Finnish individuals with MDD...
January 9, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29212563/clinically-relevant-and-simple-immune-system-measure-is-related-to-symptom-burden-in-bipolar-disorder
#15
Ole Köhler-Forsberg, Louisa Sylvia, Thilo Deckersbach, Michael Joshua Ostacher, Melvin McInnis, Dan Iosifescu, Charles Bowden, Susan McElroy, Joseph Calabrese, Michael Thase, Richard Charles Shelton, Mauricio Tohen, James Kocsis, Edward Friedman, Terence Ketter, Andrew Alan Nierenberg
OBJECTIVE: Immunological theories, particularly the sickness syndrome theory, may explain psychopathology in mood disorders. However, no clinical trials have investigated the association between overall immune system markers with a wide range of specific symptoms including potential gender differences. METHODS: We included two similar clinical trials, the lithium treatment moderate-dose use study and clinical and health outcomes initiatives in comparative effectiveness for bipolar disorder study, enrolling 765 participants with bipolar disorder...
December 7, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29212562/a-randomised-controlled-trial-of-the-monoaminergic-stabiliser-osu6162-in-treatment-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#16
Marie Karin Lena Nilsson, Olof Zachrisson, Carl-Gerhard Gottfries, Michael Matousek, Birgitta Peilot, Sara Forsmark, Robert Christiaan Schuit, Maria Lizzie Carlsson, Angelica Kloberg, Arvid Carlsson
OBJECTIVE: The monoaminergic stabiliser (-)-OSU6162 has in previous studies shown promising effects on mental fatigue after stroke and traumatic brain injury. This study investigated the safety and effectiveness of (-)-OSU6162 in patients with myalgic encephalomyelitis/chronic fatigue syndrome. METHODS: A total of 62 patients were randomly assigned to placebo or (-)-OSU6162. Primary outcomes were assessment on the mental fatigue scale (MFS) and the clinical global impression of change (CGI-C) scale...
December 7, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29208055/combinations-of-snp-genotypes-from-the-wellcome-trust-case-control-study-of-bipolar-patients
#17
Erling Mellerup, Martin Balslev Jørgensen, Henrik Dam, Gert Lykke Møller
OBJECTIVES: Combinations of genetic variants are the basis for polygenic disorders. We examined combinations of SNP genotypes taken from the 446 729 SNPs in The Wellcome Trust Case Control Study of bipolar patients. METHODS: Parallel computing by graphics processing units, cloud computing, and data mining tools were used to scan The Wellcome Trust data set for combinations. RESULTS: Two clusters of combinations were significantly associated with bipolar disorder...
December 6, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29202895/bilateral-ischaemic-lesions-of-the-medial-prefrontal-cortex-are-anxiogenic-in-the-rat
#18
Robert A Déziel, R Andrew Tasker
OBJECTIVE: Stroke patients often suffer from delayed disturbances of mood and cognition. In rodents, the prefrontal cortex (PFC) is involved in both higher order cognition and emotion. Our objective was to determine if bilateral focal ischaemic lesions restricted to the medial prefrontal cortex (mPFC) could be used to model post-stroke anxiety and/or cognitive deficits. METHODS: Groups of adult male Sprague-Dawley rats (n=9) received bilateral injections of either endothelin-1 (ET-1) (400 pmol) or vehicle (artificial cerebrospinal fluid) into the mPFC and were tested at various times using both a test of temporal order memory and in an elevated plus maze...
December 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29202894/failure-to-detect-the-action-of-antidepressants-in-the-forced-swim-test-in-swiss-mice
#19
Patrick R Suman, Nathalia Zerbinatti, Lais Cristina Theindl, Karolina Domingues, Cilene Lino de Oliveira
OBJECTIVE: The aims of this study were to replicate previously published experiments and to modify the protocol to detect the effects of chronic antidepressant treatment in mice. METHODS: Male Swiss mice (n=6-8/group) housed in reversed light/dark cycle were randomly assigned into receive vehicle (10% sucrose), sub-effective doses (1 and 3 mg/kg) or effective doses (10 and 30 mg/kg) of bupropion, desipramine, and fluoxetine and a candidate antidepressant, sodium butyrate (1-30 mg/kg) per gavage (p...
December 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29151406/towards-operationalising-internal-distractibility-mind-wandering-in-adults-with-adhd
#20
Joseph Biederman, Maura Fitzgerald, Mai Uchida, Thomas J Spencer, Ronna Fried, Jennifer Wicks, Alexandra Saunders, Stephen V Faraone
OBJECTIVE: To investigate whether specific symptoms of attention deficit hyperactivity disorder (ADHD) can help identify ADHD patients with mind wandering. METHODS: Subjects were adults ages 18-55 of both sexes (n=41) who completed the Mind-Wandering Questionnaire (MWQ) and the ADHD module of the Schedule for Affective Disorders and Schizophrenia for School-Age Children Epidemiologic Version. We used Spearman's rank correlation and Pearson's χ2 analyses to examine associations between the ADHD module and the MWQ and receiver operator characteristic (ROC) analyses to evaluate the diagnostic efficiency of the ADHD module...
December 2017: Acta Neuropsychiatrica
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