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Acta Neuropsychiatrica

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https://www.readbyqxmd.com/read/30223911/a-randomised-placebo-controlled-24-week-study-evaluating-adjunctive-brexpiprazole-in-patients-with-major-depressive-disorder
#1
Michael Bauer, Nanco Hefting, Annika Lindsten, Mette Krog Josiassen, Mary Hobart
OBJECTIVE: To evaluate brexpiprazole adjunctive to antidepressant therapies (ADTs) as maintenance treatment in patients with major depressive disorder with inadequate response to ADT, utilising a novel study design. METHODS: The study comprised an 8-week prospective treatment period with open-label ADT with double-blind placebo treatment and a 24-week randomised treatment period. Investigators and patients were blinded to treatment periods, randomisation criteria, and timing of randomisation...
September 18, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/30132427/vascular-risk-factors-and-the-relationships-between-cognitive-impairment-and-hypoperfusion-in-late-onset-alzheimer-s-disease
#2
Michio Takahashi, Yasunori Oda, Koichi Sato, Yukihiko Shirayama
OBJECTIVE: Our recent single-photon emission computed tomography (SPECT) study of patients with late-onset Alzheimer's disease (AD) revealed that regional cerebral blood flow (rCBF) was reduced in the frontal, temporal, and limbic lobes, and to a lesser degree in the parietal and occipital lobes. Moreover, these patients' scores on the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) were significantly correlated with rCBF in some gyri of the frontal, parietal, and limbic lobes...
August 22, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/30079857/magnetic-resonance-mr-spectroscopic-measurement-of-%C3%AE-aminobutyric-acid-gaba-in-major-depression-before-and-after-electroconvulsive-therapy
#3
Marie Krøll Knudsen, Jamie Near, Anne Bastholm Blicher, Poul Videbech, Jakob Udby Blicher
OBJECTIVE: Prior studies suggest that a dysregulation of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) is involved in the pathophysiology of major depression. We aimed to elucidate changes in cortical GABA content in relation to depression and electroconvulsive therapy (ECT) using magnetic resonance spectroscopy (MRS). METHODS: In total, 11 patients with major depression or depressive episode of bipolar disorder (mean pre-ECT Ham-17 of 26) and 11 healthy subjects were recruited...
August 6, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/30058525/observer-rated-retardation-but-not-agitation-corresponds-to-objective-motor-measures-in-depression
#4
Linda van Diermen, Sebastian Walther, Olivia Cools, Erik Fransen, Tom K Birkenhäger, Bernard C G Sabbe, Didier Schrijvers
OBJECTIVE: To explore the correlations between observer ratings and instrumental parameters across domains of psychomotor functioning in depression. METHOD: In total, 73 patients with major depressive disorder underwent extensive psychomotor and clinical testing. Psychomotor functioning was assessed with (i) an observer-rated scale (the CORE measure) and also objectively with (ii) 24-h actigraphy, and (iii) a fine motor drawing task. RESULTS: Observer ratings of retardation correlated with instrumental assessments of fine and gross motor functioning...
July 30, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/30022741/katakam-and-co-workers-have-not-shown-ssris-to-be-harmful-and-ineffective-and-should-stop-claiming-that-they-have
#5
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
Funded by the Danish state to provide guidance in health-related matters, the Copenhagen Trial Unit (CTU) at Rigshospitalet may cause considerable societal harm if allowing their analyses to be influenced by bias and prejudice rather than rigor and impartiality. This is why we found it worthwhile to comment on a report from the CTU in which the authors invoked analyses marred by numerous errors and methodological mistakes to claim that selective serotonin reuptake inhibitors (SSRIs) are harmful and ineffective...
July 19, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/30008280/mediator-effects-of-parameters-of-inflammation-and-neurogenesis-from-a-n-acetyl-cysteine-clinical-trial-for-bipolar-depression
#6
Bruna Panizzutti, Chiara Bortolasci, Kyoko Hasebe, Srisaiyini Kidnapillai, Laura Gray, Ken Walder, Michael Berk, Mohammadreza Mohebbi, Seetal Dodd, Clarissa Gama, Pedro V Magalhães, Susan M Cotton, Flávio Kapczinski, Ashley I Bush, Gin S Malhi, Olivia M Dean
OBJECTIVE: This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression. METHODS: This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers...
July 16, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29565002/quality-of-life-among-parents-of-south-african-children-with-autism-spectrum-disorder
#7
Ayman Alhazmi, Reneva Petersen, Kirsten A Donald
OBJECTIVE: To describe the quality of life (QOL) of South African parents caring for children with autism spectrum disorder (ASD) as compared with parents of typically developing (TD) children from the same community. METHODS: A cross-sectional study was done evaluating the QOL of parents of 52 children (26 parents of children with ASD versus 26 parents of TD children) using a structured measure, (World Health Organization Quality of Life Assessment-BREF). RESULTS: The mean age of the children with ASD was 64...
August 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29564992/the-neuropathological-study-of-myelin-oligodendrocyte-glycoprotein-in-the-temporal-lobe-of-schizophrenia-patients
#8
Tomoyasu Marui, Youta Torii, Shuji Iritani, Hirotaka Sekiguchi, Chikako Habuchi, Hiroshige Fujishiro, Kenichi Oshima, Kazuhiro Niizato, Shotaro Hayashida, Katsuhisa Masaki, Junichi Kira, Norio Ozaki
OBJECTIVE: Recent studies based on the neuroimaging analysis, genomic analysis and transcriptome analysis of the postmortem brain suggest that the pathogenesis of schizophrenia is related to myelin-oligodendrocyte abnormalities. However, no serious neuropathological investigation of this protein in the schizophrenic brain has yet been performed. In this study, to confirm the change in neuropathological findings due to the pathogenesis of this disease, we observed the expression of myelin-oligodendrocyte directly in the brain tissue of schizophrenia patients...
August 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29559020/gene-polymorphisms-and-response-to-transcranial-direct-current-stimulation-for-auditory-verbal-hallucinations-in-schizophrenia
#9
Harleen Chhabra, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anushree Bose, Sri Mahavir Agarwal, Vanteemar S Sreeraj, Damodharan Dinakaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
OBJECTIVE: Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia. METHODS: Schizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS...
August 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29559016/differential-plastic-changes-in-synthesis-and-binding-in-the-mouse-somatostatin-system-after-electroconvulsive-stimulation
#10
Mikkel Vestergaard Olesen, Casper René Gøtzsche, Søren Hofman Christiansen, David Paul Drucker Woldbye
OBJECTIVE: Electroconvulsive therapy (ECT) is regularly used to treat patients with severe major depression, but the mechanisms underlying the beneficial effects remain uncertain. Electroconvulsive stimulation (ECS) regulates diverse neurotransmitter systems and induces anticonvulsant effects, properties implicated in mediating therapeutic effects of ECT. Somatostatin (SST) is a candidate for mediating these effects because it is upregulated by ECS and exerts seizure-suppressant effects...
August 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29530104/the-association-between-school-exam-grades-and-subsequent-development-of-bipolar-disorder
#11
Steffie Damgaard Pedersen, Søren Dinesen Østergaard, Liselotte Petersen
OBJECTIVE: Prior studies have indicated that both high and low school grades are associated with development of bipolar disorder (BD), but these studies have not adjusted for parental history of mental disorder, which is a likely confounder. Furthermore, the association between school grades and bipolar I disorder (BD-I) has not been studied. Therefore, we aimed to study the association between school exam grades and subsequent development of BD and BD-I while adjusting for parental history of mental disorder...
August 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29501075/clinical-validation-of-the-psychotic-depression-assessment-scale-pdas-against-independent-global-severity-ratings-in-older-adults
#12
Tom Vermeulen, Lieve Lemey, Linda Van Diermen, Didier Schrijvers, Yamina Madani, Bernard Sabbe, Maarten J A Van Den Bossche, Roos C van der Mast, Søren D Østergaard
OBJECTIVES: According to a recent study, ratings on the Psychotic Depression Assessment Scale (PDAS) obtained via a dedicated semi-structured interview are valid measures of the severity of psychotic depression. This study aimed to further test the validity, scalability and responsiveness of the PDAS in older adults using independent ratings on the Clinical Global Impression Scale - Severity (CGI-S) and the Montgomery-Asberg Depression Rating Scale (MADRS) as references. METHODS: Ratings were performed at admission and discharge at two old age psychiatric wards in Flanders, Belgium...
August 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29409548/a-clinimetric-analysis-of-a-bprs-6-scale-for-schizophrenia-severity
#13
Per Bech, Stephen F Austin, Nina Timmerby, Thomas A Ban, Stine Bjerrum Møller
OBJECTIVE: A restricted Brief Psychiatric Rating Scale (BPRS-6) with the six schizophrenia specific items from the Positive and Negative Syndrome Scale (PANSS) has been investigated. These six items from the PANSS have recently been found to have both clinical validity and 'unidimensionality' in measuring the severity of schizophrenic states. The primary objective of this study was to evaluate the clinical validity of the BPRS-6. The secondary objective was to evaluate the 'unidimensionality' of the BPRS-6 by an 'item response theory' model...
August 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29909818/individual-responses-of-rodents-in-modelling-of-affective-disorders-and-in-their-treatment-prospective-review
#14
Haim Einat, Itamar Ezer, Nirit Z Kara, Catherine Belzung
IntroductionLack of good animal models for affective disorders, including major depression and bipolar disorder, is noted as a major bottleneck in attempts to study these disorders and develop better treatments. We suggest that an important approach that can help in the development and use of better models is attention to variability between model animals. RESULTS: Differences between mice strains were studied for some decades now, and sex differences get more attention than in the past...
June 18, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29880069/effects-of-erythropoietin-on-body-composition-and-fat-glucose-metabolism-in-patients-with-affective-disorders
#15
Maj Vinberg, Pernille Højman, Bente Klarlund Pedersen, Lars Vedel Kessing, Kamilla W Miskowiak
BACKGROUND: Erythropoietin (EPO) has been suggested to improve metabolism and also cognition, but human studies are scarce. This randomised controlled trial aimed to investigate whether EPO treatment influences body composition and fat and glycated haemoglobin (HbA1c) and fasting glucose, and whether these changes would be associated with previous observed cognitive benefits of EPO. METHOD: In total, 84 non-obese patients with treatment-resistant unipolar depression or bipolar disorder in remission were randomised to 8 weekly EPO (40,000 IU) or saline (NaCl 0...
June 8, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29911523/the-psychotic-depression-assessment-scale-pdas-in-measurement-based-care-of-patients-with-psychotic-depression
#16
Per Bech
No abstract text is available yet for this article.
June 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29310728/bdnf-and-nrg1-polymorphisms-and-temperament-in-selective-serotonin-reuptake-inhibitor-treated-patients-with-major-depression
#17
Kadri Andre, Olli Kampman, Merja Viikki, Eija Setälä-Soikkeli, Ari Illi, Nina Mononen, Terho Lehtimäki, Esa Leinonen
OBJECTIVE: We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks. METHODS: The study population consisted of 98 Finnish individuals with MDD...
June 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29212562/a-randomised-controlled-trial-of-the-monoaminergic-stabiliser-osu6162-in-treatment-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#18
Marie Karin Lena Nilsson, Olof Zachrisson, Carl-Gerhard Gottfries, Michael Matousek, Birgitta Peilot, Sara Forsmark, Robert Christiaan Schuit, Maria Lizzie Carlsson, Angelica Kloberg, Arvid Carlsson
OBJECTIVE: The monoaminergic stabiliser (-)-OSU6162 has in previous studies shown promising effects on mental fatigue after stroke and traumatic brain injury. This study investigated the safety and effectiveness of (-)-OSU6162 in patients with myalgic encephalomyelitis/chronic fatigue syndrome. METHODS: A total of 62 patients were randomly assigned to placebo or (-)-OSU6162. Primary outcomes were assessment on the mental fatigue scale (MFS) and the clinical global impression of change (CGI-C) scale...
June 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29202895/bilateral-ischaemic-lesions-of-the-medial-prefrontal-cortex-are-anxiogenic-in-the-rat
#19
Robert A Déziel, R Andrew Tasker
OBJECTIVE: Stroke patients often suffer from delayed disturbances of mood and cognition. In rodents, the prefrontal cortex (PFC) is involved in both higher order cognition and emotion. Our objective was to determine if bilateral focal ischaemic lesions restricted to the medial prefrontal cortex (mPFC) could be used to model post-stroke anxiety and/or cognitive deficits. METHODS: Groups of adult male Sprague-Dawley rats (n=9) received bilateral injections of either endothelin-1 (ET-1) (400 pmol) or vehicle (artificial cerebrospinal fluid) into the mPFC and were tested at various times using both a test of temporal order memory and in an elevated plus maze...
June 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29202894/failure-to-detect-the-action-of-antidepressants-in-the-forced-swim-test-in-swiss-mice
#20
Patrick R Suman, Nathalia Zerbinatti, Lais Cristina Theindl, Karolina Domingues, Cilene Lino de Oliveira
OBJECTIVE: The aims of this study were to replicate previously published experiments and to modify the protocol to detect the effects of chronic antidepressant treatment in mice. METHODS: Male Swiss mice (n=6-8/group) housed in reversed light/dark cycle were randomly assigned into receive vehicle (10% sucrose), sub-effective doses (1 and 3 mg/kg) or effective doses (10 and 30 mg/kg) of bupropion, desipramine, and fluoxetine and a candidate antidepressant, sodium butyrate (1-30 mg/kg) per gavage (p...
June 2018: Acta Neuropsychiatrica
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