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Acta Neuropsychiatrica

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https://www.readbyqxmd.com/read/28318471/adjunctive-n-acetylcysteine-in-depression-exploration-of-interleukin-6-c-reactive-protein-and-brain-derived-neurotrophic-factor
#1
Kyoko Hasebe, Laura Gray, Chiara Bortolasci, Bruna Panizzutti, Mohammadreza Mohebbi, Srisaiyini Kidnapillai, Briana Spolding, Ken Walder, Michael Berk, Gin Malhi, Seetal Dodd, Olivia M Dean
OBJECTIVE: This study aimed to explore effects of adjunctive N-acetylcysteine (NAC) treatment on inflammatory and neurogenesis markers in unipolar depression. METHODS: We embarked on a 12-week clinical trial of NAC (2000 mg/day compared with placebo) as an adjunctive treatment for unipolar depression. A follow-up visit was conducted 4 weeks following the completion of treatment. We collected serum samples at baseline and the end of the treatment phase (week 12) to determine changes in interleukin-6 (IL6), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following NAC treatment...
March 20, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28270247/gut-brain-actions-underlying-comorbid-anxiety-and-depression-associated-with-inflammatory-bowel-disease
#2
Áine Abautret-Daly, Elaine Dempsey, Adolfo Parra-Blanco, Carlos Medina, Andrew Harkin
Introduction Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD...
March 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28262083/exercise-works-for-depression-bridging-the-implementation-gap-and-making-exercise-a-core-component-of-treatment
#3
Felipe Barreto Schuch, Ioannis Dimitrios Morres, Panteleimon Ekkekakis, Simon Rosenbaum, Brendon Stubbs
No abstract text is available yet for this article.
March 6, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28245891/do-not-blame-the-ssris-blame-the-hamilton-depression-rating-scale
#4
Søren Dinesen Østergaard
No abstract text is available yet for this article.
March 1, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28112061/inflammation-and-depression-a-causal-or-coincidental-link-to-the-pathophysiology
#5
Brian E Leonard
This review summarises the evidence that chronic low grade inflammation triggers changes that contribute to the mental and physical ill health of patients with major depression. Inflammation, and the activation of the hypothalamic pituitary axis by stress, are normal components of the stress response but when stress is prolonged and the endocrine and immune system become chronic resulting in the activation of the peripheral macrophages, the central microglia and hypercortisolemia, the neuronal networks are damaged and become dysfunctional...
January 23, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27725006/visuospatial-memory-improvement-in-patients-with-diffuse-axonal-injury-dai-a-1-year-follow-up-study
#6
Ana Luiza Zaninotto, Jessica Elias Vicentini, Davi Jorge Fontoura Solla, Tatiana Tateishi Silva, Vinicius Monteiro de Paula Guirado, Fabrício Feltrin, Mara Cristina Souza de Lucia, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
OBJECTIVE: Diffuse axonal injury (DAI) is prevalent in traumatic brain injury (TBI), and is often associated with poor outcomes and cognitive impairment, including memory deficits. Few studies have explored visual memory after TBI and its relationship to executive functioning. Executive functioning is crucial for remembering an object's location, operating devices, driving, and route finding. We compared visual memory performance via the Rey-Osterrieth Complex Figure (ROCF) test 6 and 12 months after DAI...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27692004/inflammatory-aspects-of-epileptogenesis-contribution-of-molecular-inflammatory-mechanisms
#7
REVIEW
Feyza Alyu, Miriş Dikmen
OBJECTIVE: Epilepsy is a chronic neurological disease characterised with seizures. The aetiology of the most generalised epilepsies cannot be explicitly determined and the seizures are pronounced to be genetically determined by disturbances of receptors in central nervous system. Besides, neurotransmitter distributions or other metabolic problems are supposed to involve in epileptogenesis. Lack of adequate data about pharmacological agents that have antiepileptogenic effects point to need of research on this field...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27406788/decreased-levels-of-kynurenic-acid-in-prefrontal-cortex-in-a-genetic-animal-model-of-depression
#8
Xi-Cong Liu, Sophie Erhardt, Michel Goiny, Göran Engberg, Aleksander A Mathé
OBJECTIVE: There is a growing interest in the role of kynurenine pathway and tryptophan metabolites in the pathophysiology of depression. In the present study, the metabolism of tryptophan along the kynurenine pathway was analysed in a rat model of depression. METHODS: Kynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK) were measured by high-performance liquid chromatography (HPLC) in prefrontal cortex (PFC) and frontal cortex (FC) in a rat model of depression, the Flinders Sensitive Line (FSL) and their controls, the Flinders Resistant Line (FRL) rats...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27387606/serotonin-and-poor-neonatal-adaptation-after-antidepressant-exposure-in-utero
#9
Noera Kieviet, Vera van Keulen, Peter Marinus van de Ven, Koert Melchior Dolman, Martine Deckers, Adriaan Honig
OBJECTIVE: Infants exposed to selective antidepressants (SADs) in utero are at risk to develop poor neonatal adaptation (PNA) postpartum. As symptoms are non-specific and the aetiology of PNA is unknown, the diagnostic process is hampered. We hypothesised that the serotonin metabolism plays a role in the aetiology of PNA. METHODS: In this controlled study, infants admitted postpartum from February 2012 to August 2013 were included and followed for 3 days. Infants exposed to SADs during at least the last 2 weeks of fetal life were included in the patient group (n=63)...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27345702/effect-of-creatine-monohydrate-supplementation-on-learning-memory-and-neuromuscular-coordination-in-female-albino-mice
#10
Razia Allahyar, Atif Akbar, Furhan Iqbal
BACKGROUND: Research findings made over the last few years have highlighted the important role of creatine (Cr) in health and disease. However, limited information is available regarding the effect of Cr supplementation on cognation. Present study was designed to determine the effect of variable doses of Cr (1% and 3%) on selected parameters of female albino mice behaviour. METHODS: Following weaning, on 20th postnatal day, female albino mice were divided into three groups on the basis of dietary supplementation...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27264499/association-analyses-of-depression-and-genes-in-the-hypothalamus-pituitary-adrenal-axis
#11
Henrietta Nørmølle Buttenschøn, Jesper Krogh, Marit Nyholm Nielsen, Linda Kaerlev, Merete Nordentoft, Ole Mors
OBJECTIVE: Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been reported in depression. The aim was to investigate the potential association between depression and seven genes regulating or interfering with the HPA axis, including the gene encoding angiotensin converting enzyme (ACE). METHODS: In total, 78 single nucleotide polymorphisms (SNPs) and one insertion/deletion polymorphism were genotyped. The study included 408 individuals with depression and 289 controls...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27139778/spatial-memory-impairment-in-morris-water-maze-after-electroconvulsive-seizures
#12
Maria Svensson, Thord Hallin, Jonas Broms, Joakim Ekstrand, Anders Tingström
OBJECTIVE: Electroconvulsive therapy (ECT) is one of the most efficient treatments for severe major depression, but some patients suffer from retrograde memory loss after treatment. Electroconvulsive seizures (ECS), an animal model of ECT, have repeatedly been shown to increase hippocampal neurogenesis, and multiple ECS treatments cause retrograde amnesia in hippocampus-dependent memory tasks. Since recent studies propose that addition of newborn hippocampal neurons might degrade existing memories, we investigated whether the memory impairment after multiple ECS treatments is a cumulative effect of repeated treatments, or if it is the result of a delayed effect after a single ECS...
February 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27938441/a-dual-inhibitor-of-faah-and-trpv1-channels-shows-dose-dependent-effect-on-depression-like-behaviour-in-rats
#13
Christian Kirkedal, Gregers Wegener, Fabricio Moreira, Sâmia Regiane Lourenco Joca, Nico Liebenberg
OBJECTIVE: The cannabinoid receptor 1 (CB1) and transient receptor potential cation channel subfamily V member 1 (TRPV1) are proposed to mediate opposite behavioural responses. Their common denominator is the endocannabinoid ligand anandamide (AEA), which is believed to mediate antidepressant-like effect via CB1-R stimulation and depressive-like effect via TRPV1 activation. This is supposed to explain the bell-shaped dose-response curve for anandamide in preclinical models. METHODS: We investigated this assumption by administering the dual inhibitor of AEA hydrolysis and TRPV1 activation N-arachidonoyl-serotonin (AA-5HT) into the medial prefrontal cortex of rats...
December 12, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27938419/increased-gabaa-receptor-binding-in-amygdala-after-prenatal-administration-of-valproic-acid-to-rats
#14
Freja Bertelsen, Arne Møller, Davide Folloni, Kim Ryun Drasbek, Jørgen Scheel-Krüger, Anne M Landau
OBJECTIVE: Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD). An altered gamma-aminobutyric acid (GABA) system may be a key factor in ASD. Here we investigated possible changes in the GABA system in rats exposed to a low dose of prenatal VPA. METHOD: We performed autoradiography with [3H]muscimol, (a GABAA receptor agonist), and [11C]Ro15-4513 (a partial agonist of the GABAA α1+5 receptor subtypes), in brain sections containing amygdala, thalamus and hippocampus of rats treated prenatally with 20 mg/kg VPA or saline from the 12th day of gestation...
December 12, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923415/association-of-body-mass-index-related-single-nucleotide-polymorphisms-with-psychiatric-disease-and-memory-performance-in-a-japanese-population
#15
Midori Ninomiya-Baba, Junko Matsuo, Daimei Sasayama, Hiroaki Hori, Toshiya Teraishi, Miho Ota, Kotaro Hattori, Takamasa Noda, Ikki Ishida, Shigenobu Shibata, Hiroshi Kunugi
OBJECTIVE: Obesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population. METHODS: The subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls...
December 7, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923413/impact-of-enriched-environment-on-production-of-tau-amyloid-precursor-protein-and-amyloid-%C3%AE-peptide-in-high-fat-and-high-sucrose-fed-rats
#16
Yavuz Selvi, Hasan Serdar Gergerlioglu, Nursel Akbaba, Mehmet Oz, Ali Kandeger, Enver Ahmet Demir, Fatma Humeyra Yerlikaya, Kismet Esra Nurullahoglu-Atalik
OBJECTIVE: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. METHODS: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n=16) and standard housing condition (n=24)...
December 7, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923411/reliability-of-basal-plasma-vasopressin-concentrations-in-healthy-male-adults
#17
Daniel S Quintana, Lars T Westlye, Knut T Smerud, Ramy A Mahmoud, Per G Djupesland, Ole A Andreassen
OBJECTIVE: The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations...
December 7, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27919302/exercise-and-depression-where-do-we-go-from-here-a-rebuttal-to-schuch-et-al
#18
Fabien David Legrand, Elise Neff
No abstract text is available yet for this article.
December 6, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27919300/a-randomised-placebo-controlled-trial-of-transcranial-pulsed-electromagnetic-fields-in-patients-with-multiple-chemical-sensitivity
#19
Marie Thi Dao Tran, Sine Skovbjerg, Lars Arendt-Nielsen, Karl Bang Christensen, Jesper Elberling
OBJECTIVE: To evaluate the efficacy of transcranially applied pulsed electromagnetic fields (PEMF) on functional impairments and symptom severity in multiple chemical sensitivity (MCS) patients. METHODS: The study was conducted as a nationwide trial in Denmark using a randomised, parallel-group, double-blind and placebo-controlled design. Sample size was estimated at 40 participants. Eligibility criteria were age 18-75 years and fulfilment of the MCS case criteria...
December 6, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27805543/descending-serotonergic-and-noradrenergic-systems-do-not-regulate-the-antipruritic-effects-of-cannabinoids
#20
Zeynep Gizem Todurga, Ozgur Gunduz, Cetin Hakan Karadag, Ahmet Ulugol
BACKGROUND: For centuries, cannabinoids have been known to be effective in pain states. Itch and pain are two sensations sharing a lot in common. OBJECTIVE: The goal of this research was to observe whether the cannabinoid agonist WIN 55,212-2 reduces serotonin-induced scratching behaviour and whether neurotoxic destruction of descending serotonergic and noradrenergic pathways mediate the antipruritic effect of WIN 55,212-2. Material and methods Scratching behaviour was induced by intradermal injection of serotonin (50 µg/50 µl/mouse) to Balb/c mice...
December 2016: Acta Neuropsychiatrica
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