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Acta Neuropsychiatrica

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https://www.readbyqxmd.com/read/27938419/increased-gabaa-receptor-binding-in-amygdala-after-prenatal-administration-of-valproic-acid-to-rats
#1
Freja Bertelsen, Arne Møller, Davide Folloni, Kim Ryun Drasbek, Jørgen Scheel-Krüger, Anne M Landau
OBJECTIVE: Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD). An altered gamma-aminobutyric acid (GABA) system may be a key factor in ASD. Here we investigated possible changes in the GABA system in rats exposed to a low dose of prenatal VPA. METHOD: We performed autoradiography with [3H]muscimol, (a GABAA receptor agonist), and [11C]Ro15-4513 (a partial agonist of the GABAA α1+5 receptor subtypes), in brain sections containing amygdala, thalamus and hippocampus of rats treated prenatally with 20 mg/kg VPA or saline from the 12th day of gestation...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923415/association-of-body-mass-index-related-single-nucleotide-polymorphisms-with-psychiatric-disease-and-memory-performance-in-a-japanese-population
#2
Midori Ninomiya-Baba, Junko Matsuo, Daimei Sasayama, Hiroaki Hori, Toshiya Teraishi, Miho Ota, Kotaro Hattori, Takamasa Noda, Ikki Ishida, Shigenobu Shibata, Hiroshi Kunugi
OBJECTIVE: Obesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population. METHODS: The subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923413/impact-of-enriched-environment-on-production-of-tau-amyloid-precursor-protein-and-amyloid-%C3%AE-peptide-in-high-fat-and-high-sucrose-fed-rats
#3
Yavuz Selvi, Hasan Serdar Gergerlioglu, Nursel Akbaba, Mehmet Oz, Ali Kandeger, Enver Ahmet Demir, Fatma Humeyra Yerlikaya, Kismet Esra Nurullahoglu-Atalik
OBJECTIVE: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. METHODS: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n=16) and standard housing condition (n=24)...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923411/reliability-of-basal-plasma-vasopressin-concentrations-in-healthy-male-adults
#4
Daniel S Quintana, Lars T Westlye, Knut T Smerud, Ramy A Mahmoud, Per G Djupesland, Ole A Andreassen
OBJECTIVE: The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27919300/a-randomised-placebo-controlled-trial-of-transcranial-pulsed-electromagnetic-fields-in-patients-with-multiple-chemical-sensitivity
#5
Marie Thi Dao Tran, Sine Skovbjerg, Lars Arendt-Nielsen, Karl Bang Christensen, Jesper Elberling
OBJECTIVE: To evaluate the efficacy of transcranially applied pulsed electromagnetic fields (PEMF) on functional impairments and symptom severity in multiple chemical sensitivity (MCS) patients. METHODS: The study was conducted as a nationwide trial in Denmark using a randomised, parallel-group, double-blind and placebo-controlled design. Sample size was estimated at 40 participants. Eligibility criteria were age 18-75 years and fulfilment of the MCS case criteria...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27852343/pregnancy-and-bipolar-disorder-the-risk-of-recurrence-when-discontinuing-treatment-with-mood-stabilisers-a-systematic-review
#6
Erik Roj Larsen, Kristina Saric
OBJECTIVE: Bipolar disorder in pregnancy may be difficult to treat. The dilemma is whether the women should continue medication throughout pregnancy, and maybe accept a minor risk to harm their unborn child, or discontinue medication and increase the risk of recurrence, which can lead to maternal morbidity, thereby endangering themselves and their foetus. Design and methods In September 2016, three electronic search databases; PubMed, Scopus and PsycInfo, were used searching for clinical trials concerning this question...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27846922/brexpiprazole-in-patients-with-schizophrenia-overview-of-short-and-long-term-phase-3-controlled-studies
#7
Stephen R Marder, Mika Juhani Hakala, Mette Krog Josiassen, Peter Zhang, John Ouyang, Emmanuelle Weiller, Catherine Weiss, Mary Hobart
OBJECTIVE: Review efficacy, safety, and tolerability of brexpiprazole in patients with schizophrenia in short- and long-term phase 3 studies. METHODS: Patients experiencing a current exacerbation of schizophrenia received brexpiprazole in two fixed-dose (2 and 4 mg), 6-week, placebo-controlled studies, one flexible-dose (2-4 mg), 6-week, placebo-control and active reference study, and one fixed-dose (1-4 mg), 52-week, placebo-controlled maintenance study. RESULTS: The efficacy of brexpiprazole was demonstrated in the two short-term fixed-dose studies with statistically significant improvements from baseline in Positive and Negative Syndrome Scale (PANSS) total score compared with placebo...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28803577/auditory-brainstem-response-abr-profiling-tests-as-diagnostic-support-for-schizophrenia-and-adult-attention-deficit-hyperactivity-disorder-adhd
#8
Eva Juselius Baghdassarian, Maria Nilsson Markhed, Eva Lindström, Björn M Nilsson, Tommy Lewander
OBJECTIVE: To evaluate the performances of two auditory brainstem response (ABR) profiling tests as potential biomarkers and diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD), respectively, in an investigator-initiated blinded study design. METHOD: Male and female patients with schizophrenia (n=26) and adult ADHD (n=24) meeting Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM IV) diagnostic criteria and healthy controls (n=58) comprised the analysis set (n=108) of the total number of study participants (n=119)...
August 14, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28793939/discovery-versus-implementation-research-on-mental-disorders-in-low-and-middle-income-countries
#9
Dan J Stein, Gregers Wegener
No abstract text is available yet for this article.
August 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27498914/genetic-variation-within-grin2b-in-adolescents-with-alcohol-use-disorder-may-be-associated-with-larger-left-posterior-cingulate-cortex-volume
#10
Shareefa Dalvie, Samantha J Brooks, Valerie Cardenas, George Fein, Raj Ramesar, Dan J Stein
OBJECTIVE: Brain structure differences and adolescent alcohol dependence both show substantial heritability. However, exactly which genes are responsible for brain volume variation in adolescents with substance abuse disorders are currently unknown. The aim of this investigation was to determine whether genetic variants previously implicated in psychiatric disorders are associated with variation in brain volume in adolescents with alcohol use disorder (AUD). METHODS: The cohort consisted of 58 adolescents with DSM-IV AUD and 58 age and gender-matched controls of mixed ancestry ethnicity...
August 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28718394/multiple-possible-inaccuracies-cast-doubt-on-a-recent-report-suggesting-selective-serotonin-reuptake-inhibitors-to-be-toxic-and-ineffective
#11
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
According to a systematic review on the use of selective serotonin reuptake inhibitors (SSRIs) in adult depression that was recently published in BMC Psychiatry, the results of which have been widely disseminated in lay media, these drugs increase the risk for serious adverse events (SAEs) while exerting poor antidepressant efficacy. A cursory analysis, however, suggests the analysis of SAEs conducted by the authors to be marred by both methodological inaccuracies and blatant errors. After having corrected for these apparent mistakes, we conducted a sensitivity analysis in which we also accounted for a possible moderating effect of age; while this suggests SSRIs to be safe drugs in the non-elderly, they do confirm what is already known, that is, that they may enhance the risk for SAEs in the old...
July 18, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28714423/distinctive-neuropsychological-profiles-differentiate-patients-with-functional-memory-disorder-from-patients-with-amnestic-mild-cognitive-impairment
#12
Sarah J Wakefield, Daniel J Blackburn, Kirsty Harkness, Aijaz Khan, Markus Reuber, Annalena Venneri
OBJECTIVES: Patients with functional memory disorder (FMD) report significant memory failures in everyday life. Differentiating these patients from those with memory difficulties due to early stage neurodegenerative conditions is clinically challenging. The current study explored whether distinctive neuropsychological profiles could be established, suitable to differentiate patients with FMD from healthy individuals and those experiencing amnestic mild cognitive impairment (a-MCI). METHODS: Patients with a clinical diagnosis of FMD were compared with patients with a-MCI, and healthy matched controls on several tests assessing different cognitive functions...
July 17, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28566105/regional-differences-in-dendritic-spine-density-confer-resilience-to-chronic-social-defeat-stress
#13
Youge Qu, Chun Yang, Qian Ren, Min Ma, Chao Dong, Kenji Hashimoto
OBJECTIVE: Although alterations in the dendritic spine density in the brain regions may play a role in the stress-induced depression-like phenotype, the precise mechanisms are unknown. The aim was to investigate the role of spine density in the brain regions after chronic social defeat stress (CSDS). METHODS: We examined dendritic spine density in the medial prefrontal cortex (mPFC), CA1, CA3, dentate gyrus (DG) of hippocampus, nucleus accumbens (NAc), and ventral tegmental area (VTA) of susceptible and resilient mice after CSDS...
June 1, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28560935/medical-and-psychosocial-determinants-of-risk-of-postpartum-depression-a-cross-sectional-study
#14
Karolina Maliszewska, Mariola Bidzan, Małgorzata Świątkowska-Freund, Krzysztof Preis
OBJECTIVE: The aim of this study was to investigate the degree of risk of maternal postpartum depression during the second month of puerperium. METHOD: In total, 387 postnatal women filled out a questionnaire concerning their health and social status, as well as the following tests: the Edinburgh Postnatal Depression Scale (EPDS), the Patient Health Questionnaire-9 (PHQ-9), the Neo Five-Factor Inventory (NEO-FFI) Personality Inventory and the Berlin Social Support Scales...
May 31, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28535843/validation-of-the-semi-structured-psychotic-depression-assessment-scale-pdas-interview
#15
Rugül Köse Çinar, Søren Dinesen Østergaard
OBJECTIVE: Recently, a semi-structured interview dedicated to aid rating on the Psychotic Depression Assessment Scale (PDAS) was developed. Here, we aimed to validate PDAS ratings collected via this semi-structured interview. METHODS: A total of 50 patients with psychotic depression - 34 with unipolar psychotic depression and 16 with bipolar psychotic depression - were recruited for the study. The following aspects of validity were investigated: clinical validity, psychometric validity (scalability), and responsiveness...
May 24, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28482936/a-comparison-of-immersive-virtual-reality-with-traditional-neuropsychological-measures-in-the-assessment-of-executive-functions
#16
Sophie Melissa Clare Davison, Catherine Deeprose, Sylvia Terbeck
OBJECTIVE: This study investigated immersive virtual reality (IVR), as a novel technique to test executive function of healthy younger and older adults. We predicted IVR tasks to have greater predictive power than traditional measures when assessing age-related cognitive functioning due to the real-world validity of the tasks. METHODS: Participants (n=40) completed the Stroop colour-word test and the trail-making test (TMT) as traditional and commonly used assessments of executive functioning...
May 9, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28478778/investigation-of-serum-levels-of-sortilin-in-response-to-antidepressant-treatment
#17
Henriette Nørmølle Buttenschøn, Marit Nielsen, Simon Glerup, Ole Mors
BACKGROUND: The identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment. METHODS: The study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment...
May 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28473012/circuits-regulating-pleasure-and-happiness-evolution-and-role-in-mental-disorders
#18
Anton J M Loonen, Svetlana A Ivanova
Taking the evolutionary development of the forebrain as a starting point, the authors developed a biological framework for the subcortical regulation of human emotional behaviour which may offer an explanation for the pathogenesis of the principle symptoms of mental disorders. Appetitive-searching (reward-seeking) and distress-avoiding (misery-fleeing) behaviour are essential for all free-moving animals to stay alive and to have offspring. Even the oldest ocean-dwelling animal creatures, living about 560 million years ago and human ancestors, must therefore have been capable of generating these behaviours...
May 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28462732/anaesthesia-for-electroconvulsive-therapy-new-tricks-for-old-drugs-a-systematic-review
#19
Tobias Kvist Stripp, Martin Balslev Jorgensen, Niels Vidiendal Olsen
OBJECTIVE: The objective of this review is to investigate existing literature in order to delineate whether the use of anaesthesia and timing of seizure induction in a new and optimised way may improve the efficacy of electroconvulsive therapy (ECT). METHODS: PubMed/MEDLINE was searched for existing literature, last search on 24 June 2015. Relevant clinical studies on human subjects involving choice of anaesthetic, ventilation and bispectral index (BIS) monitoring in the ECT setting were considered...
May 2, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28485253/abstracts-scandinavian-college-of-neuropsychopharmacology-scnp-58th-annual-meeting-26-28-april-2017-copenhagen-denmark
#20
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Acta Neuropsychiatrica
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