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Acta Neuropsychiatrica

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https://www.readbyqxmd.com/read/29310728/bdnf-and-nrg1-polymorphisms-and-temperament-in-selective-serotonin-reuptake-inhibitor-treated-patients-with-major-depression
#1
Kadri Andre, Olli Kampman, Merja Viikki, Eija Setälä-Soikkeli, Ari Illi, Nina Mononen, Terho Lehtimäki, Esa Leinonen
OBJECTIVE: We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks. METHODS: The study population consisted of 98 Finnish individuals with MDD...
January 9, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29212563/clinically-relevant-and-simple-immune-system-measure-is-related-to-symptom-burden-in-bipolar-disorder
#2
Ole Köhler-Forsberg, Louisa Sylvia, Thilo Deckersbach, Michael Joshua Ostacher, Melvin McInnis, Dan Iosifescu, Charles Bowden, Susan McElroy, Joseph Calabrese, Michael Thase, Richard Charles Shelton, Mauricio Tohen, James Kocsis, Edward Friedman, Terence Ketter, Andrew Alan Nierenberg
OBJECTIVE: Immunological theories, particularly the sickness syndrome theory, may explain psychopathology in mood disorders. However, no clinical trials have investigated the association between overall immune system markers with a wide range of specific symptoms including potential gender differences. METHODS: We included two similar clinical trials, the lithium treatment moderate-dose use study and clinical and health outcomes initiatives in comparative effectiveness for bipolar disorder study, enrolling 765 participants with bipolar disorder...
December 7, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29212562/a-randomised-controlled-trial-of-the-monoaminergic-stabiliser-osu6162-in-treatment-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#3
Marie Karin Lena Nilsson, Olof Zachrisson, Carl-Gerhard Gottfries, Michael Matousek, Birgitta Peilot, Sara Forsmark, Robert Christiaan Schuit, Maria Lizzie Carlsson, Angelica Kloberg, Arvid Carlsson
OBJECTIVE: The monoaminergic stabiliser (-)-OSU6162 has in previous studies shown promising effects on mental fatigue after stroke and traumatic brain injury. This study investigated the safety and effectiveness of (-)-OSU6162 in patients with myalgic encephalomyelitis/chronic fatigue syndrome. METHODS: A total of 62 patients were randomly assigned to placebo or (-)-OSU6162. Primary outcomes were assessment on the mental fatigue scale (MFS) and the clinical global impression of change (CGI-C) scale...
December 7, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29208055/combinations-of-snp-genotypes-from-the-wellcome-trust-case-control-study-of-bipolar-patients
#4
Erling Mellerup, Martin Balslev Jørgensen, Henrik Dam, Gert Lykke Møller
OBJECTIVES: Combinations of genetic variants are the basis for polygenic disorders. We examined combinations of SNP genotypes taken from the 446 729 SNPs in The Wellcome Trust Case Control Study of bipolar patients. METHODS: Parallel computing by graphics processing units, cloud computing, and data mining tools were used to scan The Wellcome Trust data set for combinations. RESULTS: Two clusters of combinations were significantly associated with bipolar disorder...
December 6, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29202895/bilateral-ischaemic-lesions-of-the-medial-prefrontal-cortex-are-anxiogenic-in-the-rat
#5
Robert A Déziel, R Andrew Tasker
OBJECTIVE: Stroke patients often suffer from delayed disturbances of mood and cognition. In rodents, the prefrontal cortex (PFC) is involved in both higher order cognition and emotion. Our objective was to determine if bilateral focal ischaemic lesions restricted to the medial prefrontal cortex (mPFC) could be used to model post-stroke anxiety and/or cognitive deficits. METHODS: Groups of adult male Sprague-Dawley rats (n=9) received bilateral injections of either endothelin-1 (ET-1) (400 pmol) or vehicle (artificial cerebrospinal fluid) into the mPFC and were tested at various times using both a test of temporal order memory and in an elevated plus maze...
December 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29202894/failure-to-detect-the-action-of-antidepressants-in-the-forced-swim-test-in-swiss-mice
#6
Patrick R Suman, Nathalia Zerbinatti, Lais Cristina Theindl, Karolina Domingues, Cilene Lino de Oliveira
OBJECTIVE: The aims of this study were to replicate previously published experiments and to modify the protocol to detect the effects of chronic antidepressant treatment in mice. METHODS: Male Swiss mice (n=6-8/group) housed in reversed light/dark cycle were randomly assigned into receive vehicle (10% sucrose), sub-effective doses (1 and 3 mg/kg) or effective doses (10 and 30 mg/kg) of bupropion, desipramine, and fluoxetine and a candidate antidepressant, sodium butyrate (1-30 mg/kg) per gavage (p...
December 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29183417/neurological-soft-signs-significantly-differentiate-schizophrenia-patients-from-healthy-controls
#7
Konstantinos N Fountoulakis, Panagiotis Panagiotidis, Xenia Gonda, Vasilios Kimiskidis, Ioannis Nimatoudis
OBJECTIVE: Neurological soft signs (NSS) are a group of minor non-localisable neurological abnormalities found more often in patients with schizophrenia. The aim of the current study was to test for the effect of gender, age, parental age, age at onset and clinical symptomatology on NSS. Material and methods The study sample included 133 patients suffering from schizophrenia according to DSM-IV-TR (77 males and 56 females; aged 33.55±11.22 years old) and 122 normal controls (66 males and 56 females; aged 32...
November 29, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29151391/repeated-treatment-with-nitric-oxide-synthase-inhibitor-attenuates-learned-helplessness-development-in-rats-and-increases-hippocampal-bdnf-expression
#8
Laura Alves Stanquini, Caroline Biojone, Francisco Silveira Guimarães, Sâmia Regiane Joca
BACKGROUND: Nitric oxide synthase (NOS) inhibitors induce antidepressant-like effects in animal models sensitive to acute drug treatment such as the forced swimming test. However, it is not yet clear if repeated treatment with these drugs is required to induce antidepressant-like effects in preclinical models. OBJECTIVE: The aim of this study was to test the effect induced by acute or repeated (7 days) treatment with 7-nitroindazole (7-NI), a preferential inhibitor of neuronal NOS, in rats submitted to the learned helplessness (LH) model...
November 20, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29151406/towards-operationalising-internal-distractibility-mind-wandering-in-adults-with-adhd
#9
Joseph Biederman, Maura Fitzgerald, Mai Uchida, Thomas J Spencer, Ronna Fried, Jennifer Wicks, Alexandra Saunders, Stephen V Faraone
OBJECTIVE: To investigate whether specific symptoms of attention deficit hyperactivity disorder (ADHD) can help identify ADHD patients with mind wandering. METHODS: Subjects were adults ages 18-55 of both sexes (n=41) who completed the Mind-Wandering Questionnaire (MWQ) and the ADHD module of the Schedule for Affective Disorders and Schizophrenia for School-Age Children Epidemiologic Version. We used Spearman's rank correlation and Pearson's χ2 analyses to examine associations between the ADHD module and the MWQ and receiver operator characteristic (ROC) analyses to evaluate the diagnostic efficiency of the ADHD module...
December 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29151405/acta-neuropsychiatrica-and-social-media
#10
Gregers Wegener
No abstract text is available yet for this article.
December 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27938419/increased-gabaa-receptor-binding-in-amygdala-after-prenatal-administration-of-valproic-acid-to-rats
#11
Freja Bertelsen, Arne Møller, Davide Folloni, Kim Ryun Drasbek, Jørgen Scheel-Krüger, Anne M Landau
OBJECTIVE: Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD). An altered gamma-aminobutyric acid (GABA) system may be a key factor in ASD. Here we investigated possible changes in the GABA system in rats exposed to a low dose of prenatal VPA. METHOD: We performed autoradiography with [3H]muscimol, (a GABAA receptor agonist), and [11C]Ro15-4513 (a partial agonist of the GABAA α1+5 receptor subtypes), in brain sections containing amygdala, thalamus and hippocampus of rats treated prenatally with 20 mg/kg VPA or saline from the 12th day of gestation...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923415/association-of-body-mass-index-related-single-nucleotide-polymorphisms-with-psychiatric-disease-and-memory-performance-in-a-japanese-population
#12
Midori Ninomiya-Baba, Junko Matsuo, Daimei Sasayama, Hiroaki Hori, Toshiya Teraishi, Miho Ota, Kotaro Hattori, Takamasa Noda, Ikki Ishida, Shigenobu Shibata, Hiroshi Kunugi
OBJECTIVE: Obesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population. METHODS: The subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923413/impact-of-enriched-environment-on-production-of-tau-amyloid-precursor-protein-and-amyloid-%C3%AE-peptide-in-high-fat-and-high-sucrose-fed-rats
#13
Yavuz Selvi, Hasan Serdar Gergerlioglu, Nursel Akbaba, Mehmet Oz, Ali Kandeger, Enver Ahmet Demir, Fatma Humeyra Yerlikaya, Kismet Esra Nurullahoglu-Atalik
OBJECTIVE: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. METHODS: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n=16) and standard housing condition (n=24)...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27923411/reliability-of-basal-plasma-vasopressin-concentrations-in-healthy-male-adults
#14
Daniel S Quintana, Lars T Westlye, Knut T Smerud, Ramy A Mahmoud, Per G Djupesland, Ole A Andreassen
OBJECTIVE: The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27919300/a-randomised-placebo-controlled-trial-of-transcranial-pulsed-electromagnetic-fields-in-patients-with-multiple-chemical-sensitivity
#15
Marie Thi Dao Tran, Sine Skovbjerg, Lars Arendt-Nielsen, Karl Bang Christensen, Jesper Elberling
OBJECTIVE: To evaluate the efficacy of transcranially applied pulsed electromagnetic fields (PEMF) on functional impairments and symptom severity in multiple chemical sensitivity (MCS) patients. METHODS: The study was conducted as a nationwide trial in Denmark using a randomised, parallel-group, double-blind and placebo-controlled design. Sample size was estimated at 40 participants. Eligibility criteria were age 18-75 years and fulfilment of the MCS case criteria...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27852343/pregnancy-and-bipolar-disorder-the-risk-of-recurrence-when-discontinuing-treatment-with-mood-stabilisers-a-systematic-review
#16
Erik Roj Larsen, Kristina Saric
OBJECTIVE: Bipolar disorder in pregnancy may be difficult to treat. The dilemma is whether the women should continue medication throughout pregnancy, and maybe accept a minor risk to harm their unborn child, or discontinue medication and increase the risk of recurrence, which can lead to maternal morbidity, thereby endangering themselves and their foetus. Design and methods In September 2016, three electronic search databases; PubMed, Scopus and PsycInfo, were used searching for clinical trials concerning this question...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27846922/brexpiprazole-in-patients-with-schizophrenia-overview-of-short-and-long-term-phase-3-controlled-studies
#17
Stephen R Marder, Mika Juhani Hakala, Mette Krog Josiassen, Peter Zhang, John Ouyang, Emmanuelle Weiller, Catherine Weiss, Mary Hobart
OBJECTIVE: Review efficacy, safety, and tolerability of brexpiprazole in patients with schizophrenia in short- and long-term phase 3 studies. METHODS: Patients experiencing a current exacerbation of schizophrenia received brexpiprazole in two fixed-dose (2 and 4 mg), 6-week, placebo-controlled studies, one flexible-dose (2-4 mg), 6-week, placebo-control and active reference study, and one fixed-dose (1-4 mg), 52-week, placebo-controlled maintenance study. RESULTS: The efficacy of brexpiprazole was demonstrated in the two short-term fixed-dose studies with statistically significant improvements from baseline in Positive and Negative Syndrome Scale (PANSS) total score compared with placebo...
October 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28803577/auditory-brainstem-response-abr-profiling-tests-as-diagnostic-support-for-schizophrenia-and-adult-attention-deficit-hyperactivity-disorder-adhd
#18
Eva Juselius Baghdassarian, Maria Nilsson Markhed, Eva Lindström, Björn M Nilsson, Tommy Lewander
OBJECTIVE: To evaluate the performances of two auditory brainstem response (ABR) profiling tests as potential biomarkers and diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD), respectively, in an investigator-initiated blinded study design. METHOD: Male and female patients with schizophrenia (n=26) and adult ADHD (n=24) meeting Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM IV) diagnostic criteria and healthy controls (n=58) comprised the analysis set (n=108) of the total number of study participants (n=119)...
August 14, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28793939/discovery-versus-implementation-research-on-mental-disorders-in-low-and-middle-income-countries
#19
Dan J Stein, Gregers Wegener
No abstract text is available yet for this article.
August 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27498914/genetic-variation-within-grin2b-in-adolescents-with-alcohol-use-disorder-may-be-associated-with-larger-left-posterior-cingulate-cortex-volume
#20
Shareefa Dalvie, Samantha J Brooks, Valerie Cardenas, George Fein, Raj Ramesar, Dan J Stein
OBJECTIVE: Brain structure differences and adolescent alcohol dependence both show substantial heritability. However, exactly which genes are responsible for brain volume variation in adolescents with substance abuse disorders are currently unknown. The aim of this investigation was to determine whether genetic variants previously implicated in psychiatric disorders are associated with variation in brain volume in adolescents with alcohol use disorder (AUD). METHODS: The cohort consisted of 58 adolescents with DSM-IV AUD and 58 age and gender-matched controls of mixed ancestry ethnicity...
August 2017: Acta Neuropsychiatrica
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