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Heart Failure Reviews

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https://www.readbyqxmd.com/read/28993930/in-search-of-a-standard-when-analyzing-medication-adherence-in-patients-with-heart-failure-using-claims-data-a-systematic-review
#1
REVIEW
Katrin Krueger, Nina Griese-Mammen, Ingrid Schubert, Marita Kieble, Lea Botermann, Ulrich Laufs, Charlotte Kloft, Martin Schulz
To determine and address medication non-adherence is important and may improve patient outcomes. Our aim was to perform a systematic review on the operationalization of adherence measures in patients with heart failure using claims data. We searched the MEDLINE, EMBASE, and Cochrane databases. A quality check of the full-text articles was performed using the Quality in Prognosis Studies tool. We included 28 studies. Eleven studies used the medication possession ratio, 15 the proportion of days covered, and six studies used own methods to calculate medication adherence...
October 9, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28986727/dpp-4-inhibitors-and-heart-failure-a-potential-role-for-pharmacogenomics
#2
REVIEW
Chayakrit Krittanawong, Andrew Xanthopoulos, Takeshi Kitai, Natalia Branis, HongJu Zhang, Marrick Kukin
There remains an ongoing controversy regarding the safety of dipeptidyl peptidase-4 (DPP-4) inhibitors and the risk of developing heart failure (HF). In addition, none of the animal studies suggested a mechanism for the DPP-4 inhibitors and HF risk. To date, advances in pharmacogenomics have enabled the identification of genetic variants in DPP-4 gene. Studies have shown that genetic polymorphisms in the gene encoding DPP-4 may be associated with potential pathways involved in HF risk. This review discusses the contradictory findings of DPP-4 inhibitors and HF and a potential role for pharmacogenomics...
October 6, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28952056/pathophysiology-of-acute-heart-failure-syndrome-a-knowledge-gap
#3
REVIEW
Hani N Sabbah
Although much remains unknown regarding the pathophysiology of acute heart failure (AHF), precipitating events are thought to involve a complex set of interactions between the heart, kidneys, and peripheral vasculature. In addition to these interactions, which are considered the primary abnormalities in patients with AHF, several other organ systems may also be affected and contribute to disease progression. Currently available scientific literature suggests that the natural history and pathophysiology of AHF consists of two phases: (1) an "initiation phase" involving a series of triggering events, and (2) an "amplification phase," in which multiple mechanisms contribute to worsening HF and exacerbate end-organ damage...
September 26, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28948410/protective-molecular-mechanisms-of-clusterin-against-apoptosis-in-cardiomyocytes
#4
REVIEW
Rodrigo Martins Pereira, Rania A Mekary, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, José Rodrigo Pauli, Leandro Pereira de Moura
Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarction, transplant, or myocarditis. Clusterin can act directly or indirectly on apoptosis by regulating several intracellular pathways. These pathways include (1) the oxidant and inflammatory program, (2) insulin growth factor 1 (IGF-1) pathway, (3) KU70 / BCL-2-associated X protein (BAX) pathway, (4) tumor necrosis factor alpha (TNF-α) pathway, (5) BCL-2 antagonist of cell death (BAD) pathway, and (6) mitogen-activated protein kinase (MAPK) pathway...
September 25, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28944400/role-of-micrornas-in-doxorubicin-induced-cardiotoxicity-an-overview-of-preclinical-models-and-cancer-patients
#5
REVIEW
Clarissa Ruggeri, Sonia Gioffré, Felice Achilli, Gualtiero I Colombo, Yuri D'Alessandra
Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last years, several investigations focused on the possible involvement of microRNAs (miRNAs) in DOX-induced toxicity in vitro, with contrasting results. Recently, several groups employed animal models to mimic patient's condition, investigate the biological pathways perturbed by DOX, and identify diagnostic markers of cardiotoxicity...
September 25, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28900774/readmission-rate-after-ultrafiltration-in-acute-decompensated-heart-failure-a-systematic-review-and-meta-analysis
#6
REVIEW
Waqas Javed Siddiqui, Andrew R Kohut, Syed F Hasni, Jesse M Goldman, Benjamin Silverman, Ellie Kelepouris, Howard J Eisen, Sandeep Aggarwal
Significance of ultrafiltration in acute decompensated heart failure remains unclear. We performed meta-analysis to determine its role in reducing readmissions after acute decompensated heart failure. MEDLINE was searched using PUBMED from inception to March 22, 2017 for prospective randomized control trials comparing ultrafiltration to diuretics in acute decompensated heart failure. Five hundred ninety studies were found; nine studies with 820 patients were included. Studies with renal replacement therapy bar ultrafiltration, chronic decompensated heart failure, and non-English language were excluded...
September 13, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28868582/still-sour-about-lactic-acidosis-years-later-role-of-metformin-in-heart-failure
#7
REVIEW
William Kuan, Craig J Beavers, Maya E Guglin
Metformin remains a widely-used, first-line pharmacotherapy agent for patients with type 2 diabetes mellitus because of its efficacy, mild side effects, and affordability.However, use of this medication has traditionally been shunned by clinicians in patient populations that are considered at risk of lactic acidosis, such as those with heart failure. The underutilization of metformin can largely be attributed to the historical stigma of its biguanide predecessor, phenformin, and its association with lactic acidosis...
September 4, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28856513/emerging-pharmacologic-and-structural-therapies-for-hypertrophic-cardiomyopathy
#8
REVIEW
Daniel J Philipson, Eugene C DePasquale, Eric H Yang, Arnold S Baas
Hypertrophic cardiomyopathy is the most common inherited heart disease. Although it was first described over 50 years ago, there has been little in the way of novel disease-specific therapeutic development for these patients. Current treatment practice largely aims at symptomatic control using old drugs made for other diseases and does little to modify the disease course. Septal reduction by surgical myectomy or percutaneous alcohol septal ablation are well-established treatments for pharmacologic-refractory left ventricular outflow tract obstruction in hypertrophic cardiomyopathy patients...
August 31, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28849410/interdisciplinary-approach-to-compensation-of-hypoglycemia-in-diabetic-patients-with-chronic-heart-failure
#9
REVIEW
Yana Anfinogenova, Elena V Grakova, Maria Shvedova, Kristina V Kopieva, Alexander T Teplyakov, Sergey V Popov
Diabetes mellitus is a chronic disease requiring lifelong control with hypoglycemic agents that must demonstrate excellent efficacy and safety profiles. In patients taking glucose-lowering drugs, hypoglycemia is a common cause of death associated with arrhythmias, increased thrombus formation, and specific effects of catecholamines due to sympathoadrenal activation. Focus is now shifting from merely glycemic control to multifactorial approach. In the context of individual drugs and classes, this article reviews interdisciplinary strategies evaluating metabolic effects of drugs for treatment of chronic heart failure (CHF) which can mask characteristic hypoglycemia symptoms...
August 29, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28840400/therapeutic-effects-of-the-combination-of-inhaled-beta2-agonists-and-beta-blockers-in-copd-patients-with-cardiovascular-disease
#10
REVIEW
Vasiliki Petta, Fotis Perlikos, Stelios Loukides, Petros Bakakos, Athanasios Chalkias, Nicoletta Iacovidou, Theodoros Xanthos, Dorothea Tsekoura, Georgios Hillas
Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, with co-morbidities contributing to the overall severity and mortality of the disease. The incidence and prevalence of cardiovascular disease among COPD patients are high. Both disorders often co-exist, mainly due to smoking, but they also share common underlying risk factors, such as aging and low-grade systemic inflammation. The therapeutic approach is based on agents, whose pharmacological properties are completely opposed...
August 25, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28828566/communication-in-heart-failure-and-palliative-care
#11
REVIEW
Joshua Hauser
Communicating difficult information is an essential skill for clinicians of every specialty. The clinical complexity of the heart failure disease process lends itself to important opportunities to determine patient preferences about medical decisions and share information about prognosis. Nevertheless, traditionally most communication between clinicians and patients with heart failure has focused primarily on pathophysiology and treatment options. Studies indicate that patients and families wish to engage with their cardiologists in advance care planning and, when appropriate, end-of-life decision-making...
August 21, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28804855/human-heart-failure-with-preserved-ejection-versus-feline-cardiomyopathy-what-can-we-learn-from-both-veterinary-and-human-medicine
#12
REVIEW
Valentine Prat, Bertrand Rozec, Chantal Gauthier, Benjamin Lauzier
Cardiovascular affections are a growing health burden in human populations. Recent advances in cardiology have improved treatments and outcomes for myocardial infarction and arrhythmias, but other conditions still remain poorly understood. To date, the classical approach to study cardiovascular diseases involves rodent models, despite their strong differences with human cardiac physiology. In this context, this review will focus on the common traits between human and feline cardiac diseases, namely heart failure with preserved ejection fraction and feline cardiomyopathies, respectively...
August 14, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28762019/epicardial-adipose-tissue-as-a-metabolic-transducer-role-in-heart-failure-and-coronary-artery-disease
#13
REVIEW
Vaibhav B Patel, Saumya Shah, Subodh Verma, Gavin Y Oudit
Obesity and diabetes are strongly associated with metabolic and cardiovascular disorders including dyslipidemia, coronary artery disease, hypertension, and heart failure. Adipose tissue is identified as a complex endocrine organ, which by exerting a wide array of regulatory functions at the cellular, tissue and systemic levels can have profound effects on the cardiovascular system. Different terms including "epicardial," "pericardial," and "paracardial" have been used to describe adipose tissue deposits surrounding the heart...
July 31, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28736789/spiritual-distress-and-spiritual-care-in-advanced-heart-failure
#14
REVIEW
Ronald Gillilan, Sameena Qawi, Audrey J Weymiller, Christina Puchalski
As patients face serious and chronic illness, they are confronted with the realities of dying. Spiritual and existential issues are particularly prominent near the end of life and can result in significant distress. It is critical that healthcare professionals know how to address patients' and families' spiritual concerns, diagnose spiritual distress and attend to the deep suffering of patients in a way that can result in a better quality of life for patients and families. Tools such as the FICA spiritual history tool help clinicians invite patients and families to share their spiritual or existential concerns as well as sources of hope and meaning which can help them cope better with their illness...
July 24, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28733912/failing-better-a-new-paradigm-of-care
#15
EDITORIAL
Hunter Groninger
No abstract text is available yet for this article.
July 22, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28733911/effects-of-cognitive-behavioural-therapy-for-depression-in-heart-failure-patients-a-systematic-review-and-meta-analysis
#16
REVIEW
Kishaan Jeyanantham, Dipak Kotecha, Devsaagar Thanki, Rebecca Dekker, Deirdre A Lane
This systematic review and meta-analysis aimed to evaluate the effects of cognitive behavioural therapy (CBT) on depression, quality of life, hospitalisations and mortality in heart failure patients. The search strategy was developed for Ovid MEDLINE and modified accordingly to search the following bibliographic databases: PubMed, EMBASE, PsycINFO, CENTRAL and CINAHL. Databases were searched from inception to 6 March 2016 for randomised controlled trials (RCTs) or observational studies that used CBT in heart failure patients with depression or depressive symptoms...
July 22, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28730459/fetal-programming-as-a-predictor-of-adult-health-or-disease-the-need-to-reevaluate-fetal-heart-function
#17
REVIEW
Joana O Miranda, Carla Ramalho, Tiago Henriques-Coelho, José Carlos Areias
Epidemiologic and experimental evidence suggests that adverse stimuli during critical periods in utero permanently alters organ structure and function and may have persistent consequences for the long-term health of the offspring. Fetal hypoxia, maternal malnutrition, or ventricular overloading are among the major adverse conditions that can compromise cardiovascular development in early life. With the heart as a central organ in fetal adaptive mechanisms, a deeper understanding of the fetal cardiovascular physiology and of the echocardiographic tools to assess both normal and stressed pregnancies would give precious information on fetal well-being and hopefully may help in early identification of special risk groups for cardiovascular diseases later in life...
July 20, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28721466/the-moge-s-classification-for-cardiomyopathies-current-status-and-future-outlook
#18
REVIEW
Julian G Westphal, Angelos G Rigopoulos, Constantinos Bakogiannis, Sarah E Ludwig, Sophie Mavrogeni, Boris Bigalke, Torsten Doenst, Matthias Pauschinger, Carsten Tschöpe, P Christian Schulze, Michel Noutsias
Cardiomyopathies are complex diseases of multifactorial pathogenesis and have a high morbidity and mortality. Over the past decades, several revisions of classifications and definitions of cardiomyopathies have been proposed, primarily focusing on the phenotypic characterization of cardiomyopathies. The MOGE(S) classification system published in 2013 encompasses the classification of rapidly growing knowledge on genetic mutations, acquired causes (i.e., intramyocardial inflammation, viral infections), and further conditions involved in the induction of cardiomyopathies (e...
July 19, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28714039/current-role-of-echocardiography-in-cardiac-resynchronization-therapy
#19
REVIEW
Donato Mele, Matteo Bertini, Michele Malagù, Marianna Nardozza, Roberto Ferrari
Cardiac resynchronization therapy (CRT) is an established treatment for patients with heart failure and left ventricular systolic dysfunction. Patients are usually assessed by echocardiography, which provides a number of anatomical and functional information used for cardiac dyssynchrony assessment, prognostic stratification, identification of the optimal site of pacing in the left ventricle, optimization of the CRT device, and patient follow-up. Compared to other cardiac imaging techniques, echocardiography has the advantage to be non-invasive, repeatable, and safe, without exposure to ionizing radiation or nefrotoxic contrast...
July 17, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28702858/effect-of-renin-angiotensin-system-inhibitors-on-mortality-in-heart-failure-with-preserved-ejection-fraction-a-meta-analysis-of-observational-cohort-and-randomized-controlled-studies
#20
REVIEW
Hidekatsu Fukuta, Toshihiko Goto, Kazuaki Wakami, Nobuyuki Ohte
Despite the high mortality rate, there is no therapy to improve survival in heart failure with preserved ejection fraction (HFpEF). Large randomized controlled trials (RCTs) did not show clear mortality benefit of renin-angiotensin system (RAS) inhibitors (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) in HFpEF. However, because of the strict enrollment criteria, the patients who participated in these trials might represent a selected group of patients that is poorly representative of patients treated in routine clinical practice...
July 12, 2017: Heart Failure Reviews
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