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Heart Failure Reviews

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https://www.readbyqxmd.com/read/28646467/symptom-management-challenges-in-heart-failure-pharmacotherapy-considerations
#1
REVIEW
Diana Stewart, Mary Lynn McPherson
Heart failure is a chronic, progressive illness that is increasing in prevalence in the USA. Patients with advanced heart failure experience a high symptom burden that is comparable to patients with advanced cancer. Palliative care, however, is underutilized in patients with heart failure, and symptoms may go untreated as the disease progresses. A combination of pharmacologic and non-pharmacologic interventions should be used to address symptoms and maintain quality of life. While there have been significant advances in evidence-based heart failure treatments in recent years, selection of appropriate palliative medications as symptoms progress is challenging due to limited clinical studies in this patient population...
June 24, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28646466/effects-of-catheter-based-renal-denervation-on-heart-failure-with-reduced-ejection-fraction-a-systematic-review-and-meta-analysis
#2
REVIEW
Hidekatsu Fukuta, Toshihiko Goto, Kazuaki Wakami, Nobuyuki Ohte
Despite the recent advances in the management of heart failure, the mortality of heart failure patients remains high. It is of urgent need to develop new therapy for heart failure. Heart failure is characterized by increased sympathetic activity, and chronic sympathetic activation is involved in the maintenance of the pathological state. Catheter-based renal denervation (RDN) has emerged as an invasive but safe approach that can reduce sympathetic activation. Studies have reported inconsistent results regarding the effect of RDN in heart failure patients due to limited power with small sample sizes...
June 24, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28639006/angiogenic-growth-factors-in-myocardial-infarction-a-critical-appraisal
#3
REVIEW
Hemalatha Thiagarajan, UmaMaheswari Thiyagamoorthy, Iswariya Shanmugham, Gunadharini Dharmalingam Nandagopal, Anbukkarasi Kaliyaperumal
In the recent past, substantial advances have been made in the treatment of myocardial infarction (MI). Despite the impact of these positive developments, MI remains to be a leading cause of morbidity as well as mortality. An interesting hypothesis is that the development of new blood vessels (angiogenesis) or the remodeling of preexisting collaterals may form natural bypasses that could compensate for the occlusion of an epicardial coronary artery. A number of angiogenic factors are proven to be elicited during MI...
June 21, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28623475/t1-mapping-in-cardiac-mri
#4
REVIEW
Dina Radenkovic, Sebastian Weingärtner, Lewis Ricketts, James C Moon, Gabriella Captur
Quantitative myocardial and blood T1 have recently achieved clinical utility in numerous pathologies, as they provide non-invasive tissue characterization with the potential to replace invasive biopsy. Native T1 time (no contrast agent), changes with myocardial extracellular water (edema, focal or diffuse fibrosis), fat, iron, and amyloid protein content. After contrast, the extracellular volume fraction (ECV) estimates the size of the extracellular space and identifies interstitial disease. Spatially resolved quantification of these biomarkers (so-called T1 mapping and ECV mapping) are steadily becoming diagnostic and prognostically useful tests for several heart muscle diseases, influencing clinical decision-making with a pending second consensus statement due mid-2017...
June 16, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28620745/strain-imaging-using-cardiac-magnetic-resonance
#5
REVIEW
A Scatteia, A Baritussio, C Bucciarelli-Ducci
The objective assessments of left ventricular (LV) and right ventricular (RV) ejection fractions (EFs) are the main important tasks of routine cardiovascular magnetic resonance (CMR). Over the years, CMR has emerged as the reference standard for the evaluation of biventricular morphology and function. However, changes in EF may occur in the late stages of the majority of cardiac diseases, and being a measure of global function, it has limited sensitivity for identifying regional myocardial impairment. On the other hand, current wall motion evaluation is done on a subjective basis and subjective, qualitative analysis has a substantial error rate...
June 15, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28620744/introduction-to-the-special-issue-myocardial-imaging-in-heart-failure
#6
EDITORIAL
Mouaz H Al-Mallah
No abstract text is available yet for this article.
June 15, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28601914/left-ventricular-ejection-fraction-as-therapeutic-target-is-it-the-ideal-marker
#7
REVIEW
V Katsi, G Georgiopoulos, A Laina, E Koutli, J Parissis, C Tsioufis, P Nihoyannopoulos, D Tousoulis
Heart failure (HF) consists the fastest growing clinical cardiac disease. HF patients are categorized on the basis of underlying left ventricular ejection fraction (LVEF) into HF with preserved EF (HFpEF), reduced LVEF (HFrEF), and mid-range LVEF (HFmrEF). While LVEF is the most commonly used surrogate marker of left ventricular (LV) systolic function, the implementation of two-dimensional echocardiography in estimating this parameter imposes certain caveats on current HF classification. Most importantly, LVEF could fluctuate in repeated measurements or even recover after treatment, thus blunting the borders between proposed categories of HF and enabling upward classification of patients...
June 10, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28593557/assessment-of-myocardial-blood-flow-and-coronary-flow-reserve-with-positron-emission-tomography-in-ischemic-heart-disease-current-state-and-future-directions
#8
REVIEW
Firas Al Badarin, Ahmed Aljizeeri, Fatimah Almasoudi, Mouaz H Al-Mallah
Positron emission tomography (PET) is a versatile imaging technology that allows assessment of myocardial perfusion, both at a spatially relative scale and also in absolute terms, thereby enabling noninvasive evaluation of myocardial blood flow (MBF) and coronary flow reserve (CFR). Assessment of MBF using FDA-approved PET isotopes, such as (82)Rb and (13)N-ammonia, has been well validated, and several software packages are currently available, thereby allowing for MBF evaluation to be incorporated into routine workflow in contemporary nuclear laboratories...
June 7, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28589503/promise-of-adeno-associated-virus-as-a-gene-therapy-vector-for-cardiovascular-diseases
#9
REVIEW
Abesh Bera, Dwaipayan Sen
Cardiovascular diseases pose a unique threat to global mortality because it presents as one of the most diverse conglomerations of pathophysiological conditions that can create significant casualty even without straying into its collateral damage. This puts them right beside obesity and cancer in terms of severity. Their pervasive nature and high prevalence prompted biologists to seek newer prophylactic avenues of addressing this global hazard, among which adeno-associated virus (AAV) gene therapy rose to significant prominence...
June 7, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28577280/the-role-of-myocardial-viability-in-contemporary-cardiac-practice
#10
REVIEW
Abdelrahman Jamiel, Mohamad Ebid, Amjad M Ahmed, Dalia Ahmed, Mouaz H Al-Mallah
Ischemic heart disease (IHD) remains the single most common cause of death worldwide. Ischemic cardiomyopathy is a major sequel of coronary artery disease. The economic health burden of IHD is substantial. In patients with old myocardial infarction (OMI), the extent of viable myocardium (VM) directly affects the short- and long-term outcome. There is a considerable collection of observational data showing substantial improvement in patients with significant left ventricular dysfunction when the need for revascularization is guided by preoperative assessment of viability and hibernation...
June 3, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28577279/role-of-pet-to-evaluate-coronary-microvascular-dysfunction-in-non-ischemic-cardiomyopathies
#11
REVIEW
Paco E Bravo, Marcelo F Di Carli, Sharmila Dorbala
Coronary microvascular dysfunction (CMD) can result from structural and functional abnormalities at the intramural and small coronary vessel level affecting coronary blood flow autoregulation and consequently leading to impaired coronary flow reserve. CMD often co-exists with epicardial coronary artery disease but is also commonly seen in patients with various forms of heart disease, including dilated, hypertrophic, and infiltrative cardiomyopathies. CMD can go unnoticed without any symptoms, or manifest as angina, and/or dyspnea, and contribute to the development of heart failure, and even sudden death especially when co-existing with myocardial fibrosis...
June 3, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28536966/a-comprehensive-review-of-the-bioenergetics-of-fatty-acid-and-glucose-metabolism-in-the-healthy-and-failing-heart-in-nondiabetic-condition
#12
REVIEW
Ashish Gupta, Brian Houston
The function of the heart is defined by its ability to deliver adequate cardiac output to meet the requirements of the body both at rest and with exertion. To fill this role, the heart demonstrates an impressive capacity to tightly regulate energy generation and consumption. Energy production and transfer within cardiac myocytes primarily relies on the process of oxidative phosphorylation. In the failing heart, there is an imbalance between the work of the cardiac system and the energy required to generate this work...
May 24, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28497231/t2-mapping-and-t2-imaging-in-heart-failure
#13
REVIEW
A S Lota, P D Gatehouse, R H Mohiaddin
Cardiovascular magnetic resonance (CMR) is a versatile imaging modality that enables aetiological assessment and provides additional information to that of standard echocardiography in a significant proportion of patients with heart failure. In addition to highly accurate and reproducible assessment of ventricular volumes and replacement fibrosis, multiparametric mapping techniques have rapidly evolved to further expand the diagnostic and prognostic applications in various conditions ranging from acute inflammatory and ischaemic cardiomyopathy, to cardiac involvement in systemic diseases such as sarcoidosis and iron overload cardiomyopathy...
May 11, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28497230/heart-failure-with-preserved-ejection-fraction-a-nephrologist-directed-primer
#14
REVIEW
Baris Afsar, Patrick Rossignol, Loek van Heerebeek, Walter J Paulus, Kevin Damman, Stephane Heymans, Vanessa van Empel, Alan Sag, Alan Maisel, Mehmet Kanbay
There is substantial causal and consequential interaction between the ever-growing heart failure and renal failure patients. Half of the patients with heart failure (HF) have preserved left ventricular ejection fraction (HFpEF), which is difficult to diagnose and rising in prevalence relative to HF with reduced EF (HFpEF). To date, only weight reduction, exercise training, and diuretics have been shown to improve exercise tolerance and morbidity in HFpEF. This review aims to establish the baseline kidney-related concepts specific to the diagnosis and treatment of HFpEF patients and the different aspects of HFpEF and HFpEF in the clinical setting...
May 11, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28474327/pet-imaging-in-heart-failure-the-role-of-new-tracers
#15
REVIEW
Antti Saraste, Juhani Knuuti
Positron emission tomography (PET) myocardial perfusion imaging is being increasingly used for the detection of coronary artery disease. In the presence of significant left ventricle dysfunction, the assessment of myocardial ischemia and viability by PET plays a role in the identification of patients who may benefit from revascularization. In addition to these, new PET tracers may play a role in the assessment of underlying pathophysiology and therapeutic options in heart failure. Studies have shown the ability of sympathetic innervation imaging to assess the risk of cardiac death, arrhythmia, and disease progression...
May 5, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28474326/palliative-care-in-cardiac-transplantation-an-evolving-model
#16
REVIEW
Essraa Bayoumi, Farooq Sheikh, Hunter Groninger
It is currently estimated that 5.7 million Americans live with heart failure. Of these, less than 3000 will receive a heart transplant this year, according to the US Department of Health and Human Services Organ Procurement and Transplantation Network. With successful transplantation can come significant emotional and physical symptoms that are not always addressed. Although palliative care is an interdisciplinary subspecialty designed to alleviate multiple domains of suffering in serious illness, many mistakenly associate it solely with the end of life...
May 5, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28474325/a-multidimensional-sight-on-cardiac-failure-uncovered-from-structural-to-molecular-level
#17
REVIEW
Vijay Urmaliya, Gustavo Franchelli
Heart failure is one of the leading causes of death, with high mortality rate within 5 years after diagnosis. Treatment and prognosis options for heart failure primarily targeted on hemodynamic and neurohumoral components that drive progressive deterioration of the heart. However, given the multifactorial background that eventually leads to the "phenotype" named heart failure, better insight into the various components may lead to personalized treatment opportunities. Indeed, currently used criteria to diagnose and/or classify heart failure are possibly too focused on phenotypic improvement rather than the molecular driver of the disease and could therefore be further refined by integrating the leap of molecular and cellular knowledge...
May 5, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28432605/cardiac-magnetic-resonance-imaging-in-heart-failure-where-the-alphabet-begins
#18
REVIEW
Ahmed Aljizeeri, Abdulbaset Sulaiman, Naji Alhulaimi, Ahmed Alsaileek, Mouaz H Al-Mallah
Cardiac Magnetic Resonance Imaging has become a cornerstone in the evaluation of heart failure. It provides a comprehensive evaluation by answering all the pertinent clinical questions across the full pathological spectrum of heart failure. Nowadays, CMR is considered the gold standard in evaluation of ventricular volumes, wall motion and systolic function. Through its unique ability of tissue characterization, it provides incremental diagnostic and prognostic information and thus has emerged as a comprehensive imaging modality in heart failure...
April 22, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28417295/drug-induced-pulmonary-arterial-hypertension-a-review
#19
REVIEW
Lohit Garg, Ghulam Akbar, Sahil Agrawal, Manyoo Agarwal, Leila Khaddour, Rishin Handa, Aakash Garg, Mahek Shah, Brijesh Patel, Bhavinkumar D Dalal
Pulmonary arterial hypertension (PAH) is a subgroup of PH patients characterized hemodynamically by the presence of pre-capillary PH, defined by a pulmonary artery wedge pressure (PAWP) ≤15 mmHg and a PVR >3 Wood units (WU) in the absence of other causes of pre-capillary PH. According to the current classification, PAH can be associated with exposure to certain drugs or toxins such as anorectic agents, amphetamines, or selective serotonin reuptake inhibitors. With the improvement in awareness and recognition of the drug-induced PAH, it allowed the identification of additional drugs associated with an increased risk for the development of PAH...
April 18, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28405789/left-ventricular-strain-and-twisting-in-heart-failure-with-preserved-ejection-fraction-an-updated-review
#20
REVIEW
Marijana Tadic, Elisabeth Pieske-Kraigher, Cesare Cuspidi, Martin Genger, Daniel A Morris, Kun Zhang, Nina Alexandra Walther, Burket Pieske
Despite the high prevalence of the patients with heart failure with preserved ejection fraction (HFpEF), our knowledge about this entity, from diagnostic tools to therapeutic approach, is still not well established. The evaluation of patients with HFpEF is mainly based on echocardiography, as the most widely accepted tool in cardiac imaging. Identification of left ventricular (LV) diastolic dysfunction has long been considered as the only responsible for HFpEF, and its evaluation is still "sine qua non" of HFpEF diagnostics...
April 12, 2017: Heart Failure Reviews
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