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Cytokine & Growth Factor Reviews

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https://www.readbyqxmd.com/read/28233643/role-of-nod-like-receptors-in-glioma-angiogenesis-insights-into-future-therapeutic-interventions
#1
REVIEW
Shivanjali Saxena, Sushmita Jha
Gliomas are the most common solid tumors among central nervous system tumors. Most glioma patients succumb to their disease within two years of the initial diagnosis. The median survival of gliomas is only 14.6 months, even after aggressive therapy with surgery, radiation, and chemotherapy. Gliomas are heavily infiltrated with myeloid- derived cells and endothelial cells. Increasing evidence suggests that these myeloid- derived cells interact with tumor cells promoting their growth and migration. NLRs (nucleotide-binding oligomerization domain (NOD)-containing protein like receptors) are a class of pattern recognition receptors that are critical to sensing pathogen and danger associated molecular patterns...
February 9, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28190785/crosstalk-between-insulin-like-growth-factor-igf-receptor-and-integrins-through-direct-integrin-binding-to-igf1
#2
Yoshikazu Takada, Yoko K Takada, Masaaki Fujita
It has been generally accepted that integrin cell adhesion receptors are involved in growth factor signaling (integrin-growth factor crosstalk), since antagonists to integrins often suppress growth factor signaling. Partly because integrins have been originally identified as cell adhesion receptors to extracellular matrix (ECM) proteins, current models of the crosstalk between IGF1 and integrins propose that ECM ligands (e.g., vitronectin) bind to integrins and IGF1 binds to IGF receptor type 1 (IGF1R), and two separate signals merge inside the cells...
February 3, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28109670/bone-morphogenetic-protein-2-and-tumor-growth-diverse-effects-and-possibilities-for-therapy
#3
REVIEW
Haijun Tian, Jie Zhao, Elsa J Brochmann, Jeffrey C Wang, Samuel S Murray
Concern regarding safety with respect to the clinical use of human bone morphogenetic protein-2 (BMP-2) has become an increasingly controversial topic. The role of BMP-2 in carcinogenesis is of particular concern. Although there have been many studies of this topic, the results have been contradictory and confusing. We conducted a systematic review of articles that are relevant to the relationship or effect of BMP-2 on all types of tumors and a total of 97 articles were included. Studies reported in these articles were classified into three major types: "expression studies", "in vitro studies", and "in vivo studies"...
January 12, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27964967/expression-and-signaling-of-ngf-in-the-healthy-and-injured-retina
#4
REVIEW
Tarcyane Barata Garcia, Margrit Hollborn, Andreas Bringmann
This review summarizes the present knowledge concerning the retinal localization of the nerve growth factor (NGF), its precursor proNGF, and the receptors TrkA and p75(NTR) in the developing and mature rodent retina. We further discuss the changes in the expression of NGF and the receptors in experimental models of retinal disorders and diseases like inherited retinitis pigmentosa, retinal detachment, glaucoma, and diabetic retinopathy. Since proNGF is now recognized as a bioactive signaling molecule which induces cell death through p75(NTR) activation, the role of proNGF in the induction of retinal cell loss under neurodegenerative conditions is also highlighted...
December 2, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27956133/post-transcriptional-regulation-of-cytokine-and-growth-factor-signaling-in-cancer
#5
REVIEW
Irina Vlasova-St Louis, Paul R Bohjanen
Cytokines and growth factors regulate cell proliferation, differentiation, migration and apoptosis, and play important roles in coordinating growth signal responses during development. The expression of cytokine genes and the signals transmitted through cytokine receptors are tightly regulated at several levels, including transcriptional and post-transcriptional levels. A majority of cytokine mRNAs, including growth factor transcripts, contain AU-rich elements (AREs) in their 3' untranslated regions that control gene expression by regulating mRNA degradation and changing translational rates...
December 2, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27818150/-unknown-title
#6
LETTER
Hans A R Bluyssen
No abstract text is available yet for this article.
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27618303/growth-factors-as-clinical-biomarkers-of-prognosis-and-diagnosis-in-psychiatric-disorders
#7
Alma Y Galvez-Contreras, Tania Campos-Ordonez, Veronica Lopez-Virgen, Jesus Gomez-Plascencia, Rodrigo Ramos-Zuniga, Oscar Gonzalez-Perez
The psychiatric disorders are one of the most disabling illnesses in the world and represent a major problem for public health. These disorders are characterized by neuroanatomical or biochemical changes and it has been suggested that such changes may be due to inadequate neurodevelopment. Diverse alterations in the gene expression and/or serum level of specific growth factors have been implicated in the etiology, symptoms and progression of some psychiatric disorders. Herein, we summarize the latest information regarding the role of brain-derived neurotrophic factor (BDNF), epidermal growth factor (EGF), fibroblast growth factor (FGF), Insulin-like growth factor (IGF-1), neuroregulin-1 (NGR-1), erythropoietin (EPO), vascular growth factor (VEGF), transforming growth factor beta (TGF-β), nerve growth factor (NGF) and others cytokines in the pathogenesis of schizophrenia, depression, bipolar and anxiety disorders...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27522641/opposing-roles-of-il-10-in-acute-bacterial-infection
#8
Hernán F Peñaloza, Barbara M Schultz, Pamela A Nieto, Geraldyne A Salazar, Isidora Suazo, Pablo A Gonzalez, Claudia A Riedel, Manuel M Alvarez-Lobos, Alexis M Kalergis, Susan M Bueno
Interleukin-10 (IL-10) is recognized as an anti-inflammatory cytokine that downmodulates inflammatory immune responses at multiple levels. In innate cells, production of this cytokine is usually triggered after pathogen recognition receptor (PRR) engagement by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patters (DAMPs), as well as by other soluble factors. Importantly, IL-10 is frequently secreted during acute bacterial infections and has been described to play a key role in infection resolution, although its effects can significantly vary depending on the infecting bacterium...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27496752/role-of-interleukin-18-in-the-pathophysiology-of-allergic-diseases
#9
Nathan L Sanders, Anil Mishra
Interleukin (IL)-18 is an IL-1 family cytokine expressed by macrophages, dendritic cells, epithelial cells, and keratinocytes and is implicated in various aspects of both the innate and adaptive immune systems. IL-18 signals similar to IL-1β intracellularly to activate gene transcription. Since its discovery, IL-18 has been demonstrated to play a key role in pathogen defense from helminths and some bacteria. Recently however, evidence has accumulated that IL-18 expression is increased in many presentations of allergic disease...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27461871/endocytic-regulation-of-cytokine-receptor-signaling
#10
Jaroslaw Cendrowski, Agnieszka Mamińska, Marta Miaczynska
Signaling of plasma membrane receptors can be regulated by endocytosis at different levels, including receptor internalization, endocytic sorting towards degradation or recycling, and using endosomes as mobile signaling platforms. Increasing number of reports underscore the importance of endocytic mechanisms for signaling of cytokine receptors. In this short review we present both consistent and conflicting data regarding endocytosis and its role in signaling of receptors from the tumor necrosis factor receptor superfamily (TNFRSF) and those for interleukins (ILRs) and interferons (IFNRs)...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27325460/wfikkn1-and-wfikkn2-companion-proteins-regulating-tgfb-activity
#11
REVIEW
Olivier Monestier, Véronique Blanquet
The WFIKKN (WAP, Follistatin/kazal, Immunoglobulin, Kunitz and Netrin domain-containing) protein family is composed of two multidomain proteins: WFIKKN1 and WFIKKN2. They were formed by domain shuffling and are likely present in deuterostoms. The WFIKKN (also called GASP) proteins are well known for their function in muscle and skeletal tissues, namely, inhibition of certain members of the transforming growth factor beta (TGFB) superfamily such as myostatin (MSTN) and growth and differentiation factor 11 (GDF11)...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27312790/a-panoramic-review-and-in-silico-analysis-of-il-11-structure-and-function
#12
REVIEW
Manica Negahdaripour, Navid Nezafat, Younes Ghasemi
Human Interleukin (IL)-11 is a multifunctional cytokine, recognized for its thrombopoietic effects for more than two decades; clinically, IL-11 is used in the treatment of thrombocytopenia. IL-11 shares structural and functional similarities with IL-6, a related family member. In recent years, there has been a renewed interest in IL-11, because its distinct biological activities associated with cancers of epithelial origin and inflammatory disorders have been revealed. Although the crystal structure of IL-11 was resolved more than two years, a better understanding of the mechanisms of IL-11 action is required to further extend the clinical use of IL-11...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27165851/interleukin-4-receptor-signaling-and-its-binding-mechanism-a-therapeutic-insight-from-inhibitors-tool-box
#13
REVIEW
Zaheer Ul-Haq, Sehrish Naz, M Ahmed Mesaik
Studies on Interlukin-4 (IL-4) disclosed great deal of information about its various physiological and pathological roles. All these roles depend upon its interaction and signaling through either type-I (IL-4Rα/common γ-chain) or type-II (IL-4Rα/IL-13Rα) receptors. Another cytokine, IL-13, shares some of the functions of IL-4, because both cytokines use a common receptor subunit, IL-4Rα. Here in this review, we discuss the structural details of IL-4 and IL-4Rα subunit and the structural similarities between IL-4 and IL-13...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/26872860/s100a7-a-ramping-up-amp-molecule-in-psoriasis
#14
Fabio D'Amico, Evangelia Skarmoutsou, Mariagrazia Granata, Chiara Trovato, Giulio Antonino Rossi, Maria Clorinda Mazzarino
S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests that S100A7 plays critical roles in amplifying the inflammatory process in psoriatic skin, perpetuating the disease phenotype. This review will discuss the interactions between S100A7 and cytokines in psoriatic skin...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27919646/role-of-neurotrophic-factors-in-attention-deficit-hyperactivity-disorder
#15
Shih-Jen Tsai
Neurotrophins (NTs), a family of proteins including nerve growth factor, brain-derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4, are essential for neural growth, survival, and differentiation, and are therefore crucial for brain development. Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by problems of inattention and/or hyperactivity-impulsivity. ADHD is one of the most common childhood onset psychiatric disorders. Studies have suggested that both genetic and environmental factors influence the development of the disorder, although the precise causes of ADHD have not yet been identified...
November 30, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27916611/cytokine-signatures-in-hereditary-fever-syndromes-hfs
#16
REVIEW
José Noel Ibrahim, Isabelle Jéru, Jean-Claude Lecron, Myrna Medlej-Hashim
Hereditary fever syndromes (HFS) include a group of disorders characterized by recurrent self-limited episodes of fever accompanied by inflammatory manifestations occurring in the absence of infection or autoimmune reaction. Advances in the genetics of HFS have led to the identification of new gene families and pathways involved in the regulation of inflammation and innate immunity. The key role of several cytokine networks in the pathogenesis of HFS has been underlined by several groups, and supported by the rapid response of patients to targeted cytokine blocking therapies...
November 22, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27890472/dna-damage-talks-to-inflammation
#17
Idan Cohen
Interleukin-1 alpha (IL-1α) and beta (IL-1β) are pleiotropic cytokines affecting multiple cells and regulating many immune and inflammatory responses. The recent finding that nuclear IL-1α is recruited to sites of DNA damage, and its ability to actively sense and report genotoxic stress to the surrounding tissue, dramatically alters the way we view IL-1 biology. This discovery add a new face to the classical "danger theory" and show that danger signaling is not strictly limited to passive release or dying cells...
November 18, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27765498/myokines-and-adipokines-involvement-in-the-crosstalk-between-skeletal-muscle-and-adipose-tissue
#18
Fengna Li, Yinghui Li, Yehui Duan, Chien-An A Hu, Yulong Tang, Yulong Yin
Skeletal muscle and adipose tissue are the two largest organs in the body. Skeletal muscle is an effector organ, and adipose tissue is an organ that stores energy; in addition, they are endocrine organs that secrete cytokines, namely myokines and adipokines, respectively. Myokines consist of myostatin, interleukin (IL)-8, IL-15, irisin, fibroblast growth factor 21, and myonectin; adipokines include leptin, adiponectin, resistin, chemerin, and visfatin. Furthermore, certain cytokines, such as IL-6 and tumor necrosis factor-α, are released by both skeletal muscle and adipose tissue and exhibit a bioactive effect; thus, they are called adipo-myokines...
October 13, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27769579/molecular-structure-and-differential-function-of-choline-kinases-chk%C3%AE-and-chk%C3%AE-in-musculoskeletal-system-and-cancer
#19
Xi Chen, Heng Qiu, Chao Wang, Yu Yuan, Jennifer Tickner, Jiake Xu, Jun Zou
Choline, a hydrophilic cation, has versatile physiological roles throughout the body, including cholinergic neurotransmission, memory consolidation and membrane biosynthesis and metabolism. Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). PC is a major constituent of the phospholipid bilayer which constitutes the eukaryotic cell membrane, and regulates cell signal transduction...
October 8, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27743775/curcumin-as-a-natural-regulator-of-monocyte-chemoattractant-protein-1
#20
Maryam Saberi Karimian, Matteo Pirro, Muhammed Majeed, Amirhossein Sahebkar
Monocyte chemoattractant/chemotactic protein-1 (MCP-1), a member of the CC chemokine family, is one of the key chemokines that regulate migration and tissue infiltration of monocytes/macrophages. Its role in the pathophysiology of several inflammatory diseases has been widely recognized, thus making MCP-1 a possible target for anti-inflammatory treatments. Curcumin (diferuloylmethane) is a natural polyphenol derived from the rhizomes of Curcuma Longa L. (turmeric). Anti-inflammatory action underlies numerous pharmacological effects of curcumin in the control and prevention of several diseases...
October 8, 2016: Cytokine & Growth Factor Reviews
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