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Environmental Toxicology and Pharmacology

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https://www.readbyqxmd.com/read/28645054/computational-analysis-of-the-toxcast-estrogen-receptor-agonist-assays-to-predict-vitellogenin-induction-by-chemicals-in-male-fish
#1
David A Dreier, Nancy D Denslow, Christopher J Martyniuk
Endocrine disruptors, especially estrogen receptor (ER) agonists, have received considerable research attention. While there are several mechanistic endpoints for ER agonism in the Endocrine Disruptor Screening Program, there have been growing efforts to develop high-throughput screening assays and computational models to reduce testing cost, time, and animal use. For example, there are 16 ER agonist assays and an integrated computational model in ToxCast. In the present study, we examined the relationship between ToxCast ER agonist assays and model activity to male vitellogenin induction in the Fish-Short Term Reproduction Assay...
June 13, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28578144/role-of-pi3k-akt-mtor-signaling-pathway-in-dbp-induced-apoptosis-of-testicular-sertoli-cells-in-vitro
#2
Hongyan Wang, Jun Wang, Jing Zhang, Shuguang Jin, Huan Li
Dibutyl phthalate (DBP) has significant male reproductive toxicity, and the Sertoli cells are the target cells of DBP. This study was to investigate the injury effect induced by DBP on rat testicular Sertoli cells in vitro. MTT results showed that DBP can significantly reduce the survival rate of Sertoli cells; Hoechst staining results showed that the Sertoli cells treated with DBP emerged with typical morphological characteristics of apoptosis, nuclear condensation and chromatin condensation; flow cytometry results showed that DBP significantly increased the apoptotic rate of Sertoli cells, and dose-dependent; Western blotting showed that the expression of PTEN protein in Sertoli cells was significantly higher than that in the control group after treated with different concentrations of DBP for 24h, while the expression of p-PI3K1, p-AKT, p70S6K and 4E-BP1 protein in the PI3K/AKT/mTOR signal pathway were significantly decreased...
May 31, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28586725/cadmium-arsenic-selenium-and-iron-implications-for-tumor-progression-in-breast-cancer
#3
E Jablonska, K Socha, E Reszka, E Wieczorek, J Skokowski, L Kalinowski, W Fendler, B Seroczynska, M Wozniak, M H Borawska, W Wasowicz
The aim of this study was to determine Cd (cadmium) and As (arsenic) contents in human breast cancer tissues, investigate their interactions with Se (selenium) and Fe (iron), and assess their further implications for tumor progression. Metal contents were determined in 42 tissue sets (tumor and adjacent tissue) collected from 42 women diagnosed with primary breast cancer. Analytical methods included AAS and ICP-MS techniques. Significantly higher contents of Cd (p=0.0003), Se (p<0.0001) and Fe (p=0.0441) whereas significantly lower content of As (p<0...
May 30, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28599186/histological-alterations-in-gills-and-liver-of-rainbow-trout-oncorhynchus-mykiss-after-exposure-to-the-antibiotic-oxytetracycline
#4
S Rodrigues, S C Antunes, B Nunes, A T Correia
The aim of this study was to investigate the histopathological effects of oxytetracycline (OTC) on the gill and liver tissues of rainbow trouts (Oncorhynchus mykiss) following acute (96h: 0.005-50mg/L) and chronic (28days: 0.3125-5μg/L) exposures. Results suggest the existence of a cause-and-effect relationship between the exposure to OTC and tissue damage. Most predominant disorders observed in gills were progressive (e.g. hypertrophy of mucous cells and hyperplasia of epithelial cells) in acute exposure and regressive (e...
May 27, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28599185/qsar-models-for-predicting-acute-toxicity-of-pesticides-in-rainbow-trout-using-the-coral-software-and-efsa-s-openfoodtox-database
#5
Andrey A Toropov, Alla P Toropova, Marco Marzo, Jean Lou Dorne, Nikolaos Georgiadis, Emilio Benfenati
Optimal (flexible) descriptors were used to establish quantitative structure - activity relationships (QSAR) for toxicity of pesticides (n=116) towards rainbow trout. A heterogeneous set of hundreds of pesticides has been used, taken from the EFSA's chemical Hazards Database: OpenFoodTox. Optimal descriptors are preparing from simplified molecular input-line entry system (SMILES). So-called, correlation weights of different fragments of SMILES are calculating by the Monte Carlo optimization procedure where correlation coefficient between endpoint and optimal descriptor plays role of the target function...
May 23, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28528305/characterization-of-estrogenic-and-androgenic-activity-of-phthalates-by-the-xenoscreen-yes-yas-in-vitro-assay
#6
Radosław Czernych, Milena Chraniuk, Paweł Zagożdżon, Lidia Wolska
The presented study investigates and compares the estrogenic and androgenic activities of commonly used diesters of phthalic acid (phthalates) using the XenoScreen YES/YAS assay. Phthalates are commonly used plasticizers in polymers dedicated for i.e. food and drug containers. Since phthalates are not chemically bonded to the polymer, they can leach or migrate from the polymer. Therefore, phthalates are identified as contaminants in a variety of consumer products. Investigation of estrogenic and androgenic activities of phthalates (DEP, DBP, BBP, DEHP and DINP) showed no significant effect of tested substances either on hERα or hAR receptors...
May 12, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28528304/the-relationships-between-arsenic-methylation-and-both-skin-lesions-and-hypertension-caused-by-chronic-exposure-to-arsenic-in-drinking-water
#7
Binggan Wei, Jiangping Yu, Jing Wang, Linsheng Yang, Hairong Li, Chang Kong, Yajuan Xia, Kegong Wu
The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and%MMA, and lower SMI (secondary arsenic methylation index) compared to the H (hypertension) and N (without both hypertension and skin lesions) groups. The arsenic content in water which caused H may be lower than that which caused HS and S...
May 12, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28506607/corrigendum-to-the-role-of-ntcp-oatp2-bsep-and-mrp2-in-liver-injury-induced-by-dioscorea-bulbifera-l-and-diosbulbin-b-in-mice-environ-toxicol-pharmacol-51-2017-16-22
#8
Xiao-Yu Qu, Li-Na Tao, Si-Xi Zhang, Jing-Meng Sun, Jun-Qi Niu, Yan-Hua Ding, Yan-Qing Song
No abstract text is available yet for this article.
May 12, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28549314/application-of-novel-metal-organic-framework-mil-53-fe-and-its-magnetic-hybrid-for-removal-of-pharmaceutical-pollutant-doxycycline-from-aqueous-solutions
#9
Shakiba Naeimi, Hossein Faghihian
As a pharmaceutical pollutant, doxycycline causes contamination when enters into the environment. In this research MIL-53(Fe), and its magnetic hybrid MIL-53(Fe)/Fe3O4 were synthesized and employed for removal of doxycycline from aqueous solutions. The adsorbents were characterized by XRD, SEM, BET, FTIR, EDAX, VSM and TG-DTG technique. The effect of different variables such as DOC concentration, pH, contacting time, and adsorbent dose on the removal efficiency was studied and under optimized conditions the adsorption capacity of 322mgg(-1) was obtained...
May 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28527331/analysis-of-zip-zrt-irt-related-protein-transporter-gene-expression-in-murine-neural-stem-progenitor-cells
#10
Mayu Nishikawa, Hideki Mori, Masayuki Hara
Zinc plays important roles for brain development. Zrt-, Irt-related protein (ZIP) is a major transporter family to regulate the intracellular zinc levels. Neural stem/progenitor cells (NSPCs) are more sensitive than their differentiated progeny (neural/glial cells) to zinc in vitro (Nishikawa et al., 2015). We analyzed relative gene expression of 14 different ZIPs in murine NSPCs and differentiated cells by real-time polymerase chain reaction technique. Expression of Zip4 and that of Zip12 drastically increased, while that of Zip8 clearly decreased after differentiation of NSPCs...
May 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28545014/paracetamol-causes-endocrine-disruption-and-hepatotoxicity-in-male-fish-rhamdia-quelen-after-subchronic-exposure
#11
Izonete Cristina Guiloski, João Luiz Coelho Ribas, Laercio Dante Stein Piancini, Ana Carolina Dagostim, Silvana Maris Cirio, Luis Fernando Fávaro, Suelen Lúcio Boschen, Marta Margarete Cestari, Cláudio da Cunha, Helena Cristina Silva de Assis
Paracetamol is one of the most widely sold non-prescription drugs. This study aimed to evaluate the effects of the paracetamol on reproductive, biochemical, genetic, histopathological and hematogical biomarkers by waterborne exposure. Male fish of Rhamdia quelen were exposed to environmental concentrations of paracetamol (0, 0.25, 2.5μg/L) in a semi-static bioassay for 21days. Hemoglobin and hematocrit were reduced upon exposure to 0.25μg/L of paracetamol. Leukocytes and thrombocytes increased after paracetamol exposure...
May 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28531761/3%C3%AE-hydroxy-urs-12-en-28-oic-acid-confers-protection-against-znonps-induced-adversity-in-caenorhabditis-elegans
#12
Hema Negi, Shilpi Khare Saikia, Ranjana Kanaujia, Satish Jaiswal, Rakesh Pandey
Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) for overcoming the cytotoxic challenges of ZnONPs employing Ceanorhabditis elegans. The 24h LC50 of Zn-ONPs (<50nm TEM) was deduced as 4.75mgL(-1). UA (25μM) was observed to defend against this toxicity by attenuating Reactive Oxygen Species (ROS) resulting into better survival at 2mgL(-1) in a time dependent behavior...
May 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28501784/cellular-uptake-mechanism-and-clearance-kinetics-of-fluorescence-labeled-glycyrrhetinic-acid-and-glycyrrhetinic-acid-modified-liposome-in-hepatocellular-carcinoma-cells
#13
Yuqi Sun, Jinghua Lu, Dongxue Yan, Liping Shen, Haiyang Hu, Dawei Chen
Glycyrrhetinic acid (GA) is a natural pentacyclic triterpene derivative that exerts significant effects in the suppression of liver cancer. The receptors of GA on liver cells and hepatocellular carcinoma (HCC) cells have drawn broad attention. The effects of GA might depend on its transport into and out of cells. However, the question has not been previously addressed despite its obvious and fundamental importance. In this paper, GA and GA-modified liposome (GA-Lip) were labeled with fluorescein isothiocyanate (FITC) or coumarin 6 (Cou6) using chemical or pharmaceutical techniques...
May 5, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28501781/green-synthesis-of-au-cu2-xse-heterodimer-nanoparticles-and-their-in-vitro-cytotoxicity-photothermal-assay
#14
Sireesh Babu Maddinedi
We demonstrate a new route for the synthesis of heterogeneous nanoparticles (NPs) composed of a gold domain (Au) and a heavily doped semiconductor domain (Cu2-xSe) which exhibit a broad localized surface plasmon resonance (LSPR) arising from interactions between two nanocrystal domains. We also demonstrate the in-vitro cytotoxicity and photo thermal efficiency of as prepared Au-Cu2-xSe heterodimer nanoparticles. This work establishes a new way of tuning LSPR by engineering the density of free charge carriers in two interacting domains...
May 5, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28549315/associations-between-the-levels-of-thyroid-hormones-and-lipid-lipoprotein-levels-data-from-national-health-and-nutrition-examination-survey-2007-2012
#15
Ram B Jain
Data from National Health and Nutrition Examination Survey for the years 2007-2012 were used to investigate associations between thyroid hormones and lipid/lipoprotein levels for a representative sample of general US population aged ≥20 years. There were no statistically significant differences for adjusted high density lipoprotein levels among thyroid function groups, namely, subclinical hyperthyroid (SCHPR), clinical hyperthyroid (CHPR), euthyroid (EU), clinical hypothyroid (CHYP), and subclinical hypothyroid (SCHYP)...
May 4, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28505473/the-protective-study-about-alleviation-of-simvastatin-on-the-damages-of-peg-bns-in-mice
#16
Wenzhen An, Biao Han, Kang Li, Shahnaz Akhtar, Ying Zhang, Xuan Zhang, Xueli Sha, Lan Gao
Boron nitride nanoparticles have been proved to cause various toxicities, damages or inflammations after entering into in vivo in previous reports. However, up to now, there are rare investigations about the alleviation of damages caused by nanoparticles in vivo through natural small molecule drugs. Therefore, in this work, PEG-BNs with high solubility was successfully synthesized, and then their biodistribution in mice were studied using radiolabeling technique. And the heart, lung, liver, spleen, kidney tissues and blood samples were done for histology and biochemical analysis...
May 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28501782/combination-of-the-electro-fe-3-peroxydisulfate-pds-process-with-activated-sludge-culture-for-the-degradation-of-sulfamethazine
#17
Amina Ledjeri, Idris Yahiaoui, Hakima Kadji, Farida Aissani-Benissad, Abdeltif Amrane, Florence Fourcade
In this paper, the major factors affecting the degradation and the mineralization of sulfamethazine by Electro/Fe(3+)/peroxydisulfate (PDS) process (e.g. current density, PDS concentration, Fe(3+) ions concentration and initial sulfamethazine (SMT) concentration) were evaluated. The relevance of this process as a pretreatment prior to activated sludge culture was also examined. Regarding the impact on SMT degradation and mineralization, the obtained results showed that they were significantly enhanced by increasing the current density and the PDS concentrations in the ranges 1-40mAcm(-2) and from 1 to 10mM respectively; while they were negatively impacted by an increase of the initial SMT concentration and the Fe(3+) concentration, from 0...
May 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28499266/model-based-optimization-of-parameters-for-degradation-reaction-of-an-organophosphorus-pesticide-paraoxon-using-ceo2-nanoparticles-in-water-media
#18
Alicia Salerno, Isabelle Pitault, Thierry Devers, Jocelyne Pelletier, Stéphanie Briançon
Degradation and body surface decontamination is vital to prevent the skin penetration of paraoxon (POX), an organophosphorus pesticide, and victims poisoning. CeO2 demonstrated a good efficacy for the degradation of POX. The aim of the study was to develop a model which includes the impact of weight of CeO2, POX and diluent volumes on the degradation kinetics. The modelling was realized with rapid and simple experiments carried out in tubes, in aqueous diluent which contained ions in order to be in accordance with in vitro skin decontamination conditions...
May 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28505474/the-effect-of-passive-and-active-exposure-to-tobacco-smoke-on-lipid-profile-parameters-and-the-activity-of-certain-membrane-enzymes-in-the-blood-of-women-in-the-first-trimester-of-pregnancy
#19
Anna Bizoń, Halina Milnerowicz
The effect of tobacco smoke on lipid peroxidation, the lipid profile and membrane-bound enzymatic activity in the first trimester of pregnancy was investigated. In the plasma of women with active exposure to tobacco smoke, we have found increased lipid peroxidation and higher total concentrations of cholesterol, triglycerides and low-density lipoproteins in the blood, as well as a decreased concentration of high-density lipoproteins. A higher concentration of low-density lipoproteins and a lower concentration of high-density lipoproteins were also found in the plasma of passive smokers...
April 27, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28501783/silencing-of-dna-repair-sensitizes-pediatric-brain-tumor-cells-to-%C3%AE-irradiation-using-gold-nanoparticles
#20
Zuliang Liu, Huiru Yan, Hongsha Li
We present a nanoparticle (NP)-mediated delivery vehicle that effectively carries and protects siRNA in pediatric ependymoma (EP) and medulloblastoma (MB) cells. The delivery vehicle consists of gold NPs coated with a polymeric shell comprising polyethylene glycol (PG), chitosan and polyethyleneimine (Au-CP-PEI). NPs loaded with siRNA knocked down Ape1 expression by over 75% in both MB and EP cells. Further, this reduction in Ape1 expression is associated with an increase in DNA damage after irradiation. The results indicate that NP-associated delivery of siApe1 is a feasible approach to circumventing pediatric brain tumor resistance to radiation therapy...
April 27, 2017: Environmental Toxicology and Pharmacology
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