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Environmental Toxicology and Pharmacology

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https://www.readbyqxmd.com/read/28806580/the-eco-toxic-effects-of-pesticide-and-heavy-metal-mixtures-towards-earthworms-in-soil
#1
REVIEW
Herman Uwizeyimana, Meie Wang, Weiping Chen, Kifayatullah Khan
Earthworms are the key soil organisms, contribute to many positive ecological services that could be degraded by pesticides and other soil pollutants such as heavy metals. Chemicals usually occur as mixtures in the environmental systems which can lead synergistic effects. The assessment and characterization of soil pollutants that effects risks are very difficult due to the complexity of soil matrix, poor understanding about the fate and effects of chemical combinations like pesticide and metal mixtures in terrestrial systems, and scarcity of toxicological data on mixtures of pollutants...
August 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28802958/interaction-of-erythromycin-and-ketoconazole-on-the-neurological-biochemical-and-behavioral-responses-in-crucian-carp
#2
Jianchao Liu, Yuanfei Cai, Guanghua Lu, Xiaoxiang Dan, Donghai Wu, Zhenhua Yan
The presence of pharmaceuticals in the aquatic environment has received great attention due to their potential impacts on public health. The single, as well as the combined toxicities of erythromycin (ERY) and ketoconazole (KCZ) on the bioaccumulation, biochemical and behavioral responses, were examined in crucian carp. This study focused on the uptake of contaminants, acetylcholinesterase (AChE) activity in the brain, swimming and shoaling behavior of fish. After 14days of binary exposure, the addition of KCZ at nominal concentrations of 0...
August 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28800561/vaccination-is-fundamental-but-can-it-escape-from-a-more-insightful-and-critical-information-about-its-action
#3
LETTER
Salvatore Chirumbolo, Geir Bjørklund
No abstract text is available yet for this article.
July 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28787644/mitochondrial-dysfunction-and-inflammatory-response-in-the-cytotoxicity-of-nr8383-macrophages-induced-by-fine-particulate-matter
#4
Qi Xiong, Qin Ru, Lin Chen, Xiang Tian, Chaoying Li
Exposure to fine particulate matter (fine PM) is known to cause severe public health problems. However, the potential mechanisms of alveolar macrophages cytotoxicity induced by fine PM exposure are still unclear. The aim of this study was to determine if both the mitochondrial dysfunction and the inflammatory response of NR8383 macrophages were triggered by Standard Reference Material 2786 (SRM 2786) for fine PM. NR8383 cells were exposed to different concentrations of SRM 2786, mitochondrial membrane potential, ultrastructure of mitochondria, activities of caspase 3/9, release of IL-6/TNF-α, expression of NF-κB and IκBα were evaluated...
July 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28778020/long-term-effect-of-dietary-overload-lithium-on-the-glucose-metabolism-in-broiler-chickens
#5
Shiping Bai, Shuqin Pan, Keying Zhang, Xuemei Ding, Jianping Wang, Qiufeng Zeng, Yue Xuan, Zuowei Su
Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35days. Compared to controls, glucose disappearance rates were lower (p=0.035) 15-120min after glucose gavage, and blood glucose concentrations were lower (p=0.038) 30min after insulin injection in overload lithium broilers...
July 22, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28755625/x-ray-irradiation-has-positive-effects-for-the-recovery-of-peripheral-nerve-injury-maybe-through-the-vascular-smooth-muscle-contraction-signaling-pathway
#6
Bo Jiang, Yong Zhang, Chang She, Jiaju Zhao, Kailong Zhou, Zhicheng Zuo, Xiaozhong Zhou, Peiji Wang, Qirong Dong
INTRODUCTION: It is well known that moderate to high doses of ionizing radiation have a toxic effect on the organism. However, there are few experimental studies on the mechanisms of LDR ionizing radiation on nerve regeneration after peripheral nerve injury. METHODS: We established the rats' peripheral nerve injury model via repaired Peripheral nerve injury nerve, vascular endothelial growth factor a and Growth associated protein-43 were detected from different treatment groups...
July 22, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28763719/dynamic-responses-of-antioxidant-enzymes-in-pearl-oyster-pinctada-martensii-exposed-to-di-2-ethylhexyl-phthalate-dehp
#7
Nan Xiang, Chunfeng Zhao, Xiaoping Diao, Qian Han, Hailong Zhou
Di(2-ethylhexyl) phthalate (DEHP) is recognized as one of the most ubiquitous contaminants in marine environments and causes adverse effects on the health of marine organisms. The purpose of this study was to investigate the toxic effects of DEHP on the pearl oyster Pinctada martensii. The Pinctada martensii was exposed to 0.0, 0.5, 2, 8, or 32mgL(-1) DEHP for 7 and 10days using parameters of antioxidant. Antioxidant indicators included levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), peroxidase (POD), and total antioxidant capacity (T-AOC) in the gills and hepatopancreas of Pinctada martensii for 7 and 10days...
July 20, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28743066/toxic-effects-of-juvenile-sablefish-anoplopoma-fimbria-by-ammonia-exposure-at-different-water-temperature
#8
Jun-Hwan Kim, Hee-Ju Park, In-Ki Hwang, Jae-Min Han, Do-Hyung Kim, Chul Woong Oh, Jung-Sick Lee, Ju-Chan Kang
Juvenile sablefish, Anoplopoma fimbria (mean length 17.1±2.4cm, and mean weight 75.6±5.7g) were used to evaluate toxic effects on antioxidant systems, immune responses, and stress indicators by ammonia exposure (0, 0.25, 0.75, and 1.25mg/L) at different water temperature (12 and 17°C) in 1 and 2 months. In antioxidant responses, superoxide dismutase (SOD) and catalase (CAT) were significantly increased by ammonia exposure, whereas glutathione (GSH) was decreased. In immune responses, lysozyme and phagocytosis activity were significantly increased by ammonia exposure...
July 19, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28738286/emodin-suppresses-cadmium-induced-osteoporosis-by-inhibiting-osteoclast-formation
#9
Xiao Chen, Shuai Ren, Guoying Zhu, Zhongqiu Wang, Xiaolin Wen
Environmental level of cadmium (Cd) exposure can induce bone loss. Emodin, a naturally compound found in Asian herbal medicines, could influence osteoblast/osteoclast differentiation. However, the effects of emodin on Cd-induced bone damage are not clarified. The aim of this study was to investigate the role of emodin on Cd-induced osteoporosis. Sprague-Dawley male rats were divided into three groups which were given 0mg/L, 50mg Cd/L and 50mg Cd/L plus emodin (50mg/kg body weight). Bone histological investigation, microCT analysis, metabolic biomarker determination and immunohistochemical staining were performed at the 12th week...
July 18, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28787675/biocompatibility-and-fabrication-of-rgo-chitosan-film-for-cartilage-tissue-recovery
#10
Lei Cao, Chunwen Lu, Qiugen Wang, Fan Li
Graphene oxide (GO) has been successfully deoxygenated via an environmental friendly approach using chitosan. The prepared RGO was characterized using several microscopic and spectroscopic techniques. Also, the synthesized RGO is used to develop a highly compatible film with chitosan. Further, the in-vitro cytotoxicity results showed the biocompatible nature of prepared RGO/chitosan composite towards the human articular chondrocytes indicating their use in future cartilage tissue engineering applications.
July 17, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28734242/environmental-estrogen-s-induced-swimming-behavioural-alterations-in-adult-zebrafish-danio-rerio
#11
Basavaraj B Goundadkar, Pancharatna Katti
The present study is an attempt to investigate the effects of long-term (75days) exposure to environmental estrogens (EE) on the swimming behaviour of zebrafish (Danio rerio). Adult zebrafish were exposed semi-statically to media containing commonly detected estrogenic water contaminants (EE2, DES and BPA) at a concentration (5ng/L) much lower than environmentally recorded levels. Time spent in swimming, surface preference, patterns and path of swimming were recorded (6mins) for each fish using two video cameras on day 15, 30 60 and 75...
July 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28728133/zebrafish-have-an-ethanol-inducible-hepatic-4-nitrophenol-hydroxylase-that-is-not-cyp2e1-like
#12
Jessica H Hartman, Jordan S Kozal, Richard T Di Giulio, Joel N Meyer
Zebrafish are an attractive model organism for toxicology; however, an important consideration in translating between species is xenobiotic metabolism/bioactivation. CYP2E1 metabolizes small hydrophobic molecules, e.g. ethanol, cigarette smoke, and diesel exhaust components. CYP2E1 is thought to only be conserved in mammals, but recent reports identified homologous zebrafish cytochrome P450s. Herein, ex vivo biochemical measurements show that unlike mammals, zebrafish possess a low-affinity 4-nitrophenol hydroxylase (Km ∼0...
July 10, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28710931/ligustrazine-modulates-renal-cysteine-biosynthesis-in-rats-exposed-to-cadmium
#13
Wenhua Kuang, Xu Zhang, Wufu Zhu, Zhou Lan
The objective of this study was to determine the effect of ligustrazine (TMP) on cadmium (Cd)-induced nephrotoxicity and its relevant mechanism. TMP (50mg/kg) was injected intraperitoneally (i.p.) into rats 1h prior to CdCl2 exposure (at a Cd dose of 0.6mg/kg). TMP reversed Cd-induced nephrotoxicity, evidenced by the relatively normal architecture of the renal cortex. Additionally, TMP alleviated renal oxidative stress of rats that were exposed to Cd, evidenced by the decreased levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), elevated levels of glutathione (GSH) and GSH/GSSG (glutathione disulfide) ratios...
July 9, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28704756/protective-role-of-dietary-spirulina-platensis-against-diazinon-induced-oxidative-damage-in-nile-tilapia-oreochromis-niloticus
#14
Nevien K M Abdelkhalek, Ismail A M Eissa, Eman Ahmed, Omnia E Kilany, Mohamed El-Adl, Mahmoud A O Dawood, Ahmed M Hassan, Mohamed M Abdel-Daim
The current study was performed to investigate the ameliorating effect of dietary supplementation of 0.5 and 1% Spiurolina platensis (SP) diet against the sub-acute toxicity of diazinon (DZN) 0.28mg/L in Nile tilapia. At the end of experiment after 28days, hepatic and renal damage markers (aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid and creatinine), serum biochemical parameters (total proteins, albumin, cholesterol and glucose) and tissue antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and malondialdehyde) were detesrmined...
July 5, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28704753/resveratrol-improves-prostate-fibrosis-during-progression-of-urinary-dysfunction-in-chronic-prostatitis
#15
Yi He, Hui-Zhi Zeng, Yang Yu, Jia-Shu Zhang, Xingping Duan, Xiao-Na Zeng, Feng-Tao Gong, Qi Liu, Bo Yang
AIM: We investigated whether prostate fibrosis was associated with urinary dysfunction in chronic prostatitis (CP) and whether resveratrol improved urinary dysfunction and the underlying molecular mechanism. METHODS: Rat model of CP was established via subcutaneous injections of DPT vaccine and subsequently treated with resveratrol. Bladder pressure and volume tests investigated the effect of resveratrol on urinary dysfunction in CP rats. Western blotting and immunohistochemical staining examined the expression level of C-kit/SCF and TGF-β/Wnt/β-catenin...
July 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28704751/protective-effect-of-ferulic-acid-on-cisplatin-induced-nephrotoxicity-in-rats
#16
Erliasa Bami, Ozlem Bingol Ozakpınar, Zarife Nigar Ozdemir-Kumral, Kutay Köroglu, Feriha Ercan, Zeynep Cirakli, Turgut Sekerler, Fikret Vehbi Izzettin, Mesut Sancar, Betul Okuyan
This study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p<0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group...
July 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28697452/effect-of-fluoride-exposure-on-mrna-expression-of-cav1-2-and-calcium-signal-pathway-apoptosis-regulators-in-pc12-cells
#17
Qiuxia Liao, Rui Zhang, Xiaoyu Wang, Weiwei Nian, Lulu Ke, Wei Ouyang, Zigui Zhang
This study investigated the effects of fluoride exposure on the mRNA expression of Cav1.2 calcium signaling pathway and apoptosis regulatory molecules in PC12 cells. The viability of PC12 cell receiving high fluoride (5.0mM) and low fluoride (0.5mM) alone or fluoride combined with L-type calcium channel (LTCC) agonist/inhibitor (5umol/L FPL6417/2umol/L nifedipine) was detected using cell counting kit-8 at different time points (2, 4, 6, 8, 12, 10, and 24h). Changes in the cell configuration were observed after exposing the cells to fluoride for 24h...
June 30, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28728132/melatonin-protect-the-development-of-preimplantation-mouse-embryos-from-sodium-fluoride-induced-oxidative-injury
#18
Jiamin Zhao, Beibei Fu, Wei Peng, Tingchao Mao, Haibo Wu, Yong Zhang
Recently study shows that melatonin can protect embryos from the culture environment oxidative stress. However, the protective effect of melatonin on the mouse development of preimplantation embryos under sodium fluoride (NaF) induced oxidative stress is still unclear. Here, we showed that exposure to NaF significantly increased the reactive oxygen species (ROS) level, decreased the blastocyst formation rates, and increased the fragmentation, apoptosis and retardation of blastocysts in the development of mouse preimplantation embryos...
June 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28704755/oral-warfarin-intake-affects-skin-inflammatory-cytokine-responses-in-rats
#19
Aleksandra Popov Aleksandrov, Ivana Mirkov, Lidija Zolotarevski, Marina Ninkov, Dina Mileusnic, Dragan Kataranovski, Milena Kataranovski
Warfarin is an anticoagulant used in prevention/prophylaxis of thromboembolism. Besides the effects on coagulation, non-hemorrhagic reactions have also been documented. Although cutaneous reactions were reported in some patients, the impact on skin immunity was not explored. In the present paper, the effect of 30-day oral warfarin intake on skin cytokine responses in rats was analyzed. Increased release of inflammatory cytokines (TNF, IL-1β and IL-10) was noted by skin explants from rats which received warfarin, but without effect on IL-6...
June 28, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28704754/metabolomics-study-of-cadmium-induced-diabetic-nephropathy-and-protective-effect-of-caffeic-acid-phenethyl-ester-using-uplc-q-tof-ms-combined-with-pattern-recognition
#20
Pin Gong, Xiangna Chang, Xuefeng Chen, Xiaohuan Bai, He Wen, Sihui Pi, Wenjuan Yang, Lan Wang, Fuxin Chen
Diabetic nephropathy (DN) is the most severe complication of diabetes and multiple factors are involved in the pathogenesis of DN. Among them, cadmium (Cd) acts as a risk factor inducing the occurrence of DN. The present study focused on investigating the protective role of caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, against Cd-induced DN in mice based on ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS)and pattern recognition...
June 28, 2017: Environmental Toxicology and Pharmacology
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