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Environmental Toxicology and Pharmacology

Radosław Czernych, Milena Chraniuk, Paweł Zagożdżon, Lidia Wolska
The presented study investigates and compares the estrogenic and androgenic activities of commonly used diesters of phthalic acid (phthalates) using the XenoScreen YES/YAS assay. Phthalates are commonly used plasticizers in polymers dedicated for i.e. food and drug containers. Since phthalates are not chemically bonded to the polymer, they can leach or migrate from the polymer. Therefore, phthalates are identified as contaminants in a variety of consumer products. Investigation of estrogenic and androgenic activities of phthalates (DEP, DBP, BBP, DEHP and DINP) showed no significant effect of tested substances either on hERα or hAR receptors...
May 12, 2017: Environmental Toxicology and Pharmacology
Binggan Wei, Jiangping Yu, Jing Wang, Linsheng Yang, Hairong Li, Chang Kong, Yajuan Xia, Kegong Wu
The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and%MMA, and lower SMI (secondary arsenic methylation index) compared to the H (hypertension) and N (without both hypertension and skin lesions) groups. The arsenic content in water which caused H may be lower than that which caused HS and S...
May 12, 2017: Environmental Toxicology and Pharmacology
Xiao-Yu Qu, Li-Na Tao, Si-Xi Zhang, Jing-Meng Sun, Jun-Qi Niu, Yan-Hua Ding, Yan-Qing Song
No abstract text is available yet for this article.
May 12, 2017: Environmental Toxicology and Pharmacology
Mayu Nishikawa, Hideki Mori, Masayuki Hara
Zinc plays important roles for brain development. Zrt-, Irt-related protein (ZIP) is a major transporter family to regulate the intracellular zinc levels. Neural stem/progenitor cells (NSPCs) are more sensitive than their differentiated progeny (neural/glial cells) to zinc in vitro (Nishikawa et al., 2015). We analyzed relative gene expression of 14 different ZIPs in murine NSPCs and differentiated cells by real-time polymerase chain reaction technique. Expression of Zip4 and that of Zip12 drastically increased, while that of Zip8 clearly decreased after differentiation of NSPCs...
May 11, 2017: Environmental Toxicology and Pharmacology
Yuqi Sun, Jinghua Lu, Dongxue Yan, Liping Shen, Haiyang Hu, Dawei Chen
Glycyrrhetinic acid (GA) is a natural pentacyclic triterpene derivative that exerts significant effects in the suppression of liver cancer. The receptors of GA on liver cells and hepatocellular carcinoma (HCC) cells have drawn broad attention. The effects of GA might depend on its transport into and out of cells. However, the question has not been previously addressed despite its obvious and fundamental importance. In this paper, GA and GA-modified liposome (GA-Lip) were labeled with fluorescein isothiocyanate (FITC) or coumarin 6 (Cou6) using chemical or pharmaceutical techniques...
May 5, 2017: Environmental Toxicology and Pharmacology
Sireesh Babu Maddinedi
We demonstrate a new route for the synthesis of heterogeneous nanoparticles (NPs) composed of a gold domain (Au) and a heavily doped semiconductor domain (Cu2-xSe) which exhibit a broad localized surface plasmon resonance (LSPR) arising from interactions between two nanocrystal domains. We also demonstrate the in-vitro cytotoxicity and photo thermal efficiency of as prepared Au-Cu2-xSe heterodimer nanoparticles. This work establishes a new way of tuning LSPR by engineering the density of free charge carriers in two interacting domains...
May 5, 2017: Environmental Toxicology and Pharmacology
Wenzhen An, Biao Han, Kang Li, Shahnaz Akhtar, Ying Zhang, Xuan Zhang, Xueli Sha, Lan Gao
Boron nitride nanoparticles have been proved to cause various toxicities, damages or inflammations after entering into in vivo in previous reports. However, up to now, there are rare investigations about the alleviation of damages caused by nanoparticles in vivo through natural small molecule drugs. Therefore, in this work, PEG-BNs with high solubility was successfully synthesized, and then their biodistribution in mice were studied using radiolabeling technique. And the heart, lung, liver, spleen, kidney tissues and blood samples were done for histology and biochemical analysis...
May 1, 2017: Environmental Toxicology and Pharmacology
Amina Ledjeri, Idris Yahiaoui, Hakima Kadji, Farida Aissani-Benissad, Abdeltif Amrane, Florence Fourcade
In this paper, the major factors affecting the degradation and the mineralization of sulfamethazine by Electro/Fe(3+)/peroxydisulfate (PDS) process (e.g. current density, PDS concentration, Fe(3+) ions concentration and initial sulfamethazine (SMT) concentration) were evaluated. The relevance of this process as a pretreatment prior to activated sludge culture was also examined. Regarding the impact on SMT degradation and mineralization, the obtained results showed that they were significantly enhanced by increasing the current density and the PDS concentrations in the ranges 1-40mAcm(-2) and from 1 to 10mM respectively; while they were negatively impacted by an increase of the initial SMT concentration and the Fe(3+) concentration, from 0...
May 1, 2017: Environmental Toxicology and Pharmacology
Alicia Salerno, Isabelle Pitault, Thierry Devers, Jocelyne Pelletier, Stéphanie Briançon
Degradation and body surface decontamination is vital to prevent the skin penetration of paraoxon (POX), an organophosphorus pesticide, and victims poisoning. CeO2 demonstrated a good efficacy for the degradation of POX. The aim of the study was to develop a model which includes the impact of weight of CeO2, POX and diluent volumes on the degradation kinetics. The modelling was realized with rapid and simple experiments carried out in tubes, in aqueous diluent which contained ions in order to be in accordance with in vitro skin decontamination conditions...
May 1, 2017: Environmental Toxicology and Pharmacology
Anna Bizoń, Halina Milnerowicz
The effect of tobacco smoke on lipid peroxidation, the lipid profile and membrane-bound enzymatic activity in the first trimester of pregnancy was investigated. In the plasma of women with active exposure to tobacco smoke, we have found increased lipid peroxidation and higher total concentrations of cholesterol, triglycerides and low-density lipoproteins in the blood, as well as a decreased concentration of high-density lipoproteins. A higher concentration of low-density lipoproteins and a lower concentration of high-density lipoproteins were also found in the plasma of passive smokers...
April 27, 2017: Environmental Toxicology and Pharmacology
Zuliang Liu, Huiru Yan, Hongsha Li
We present a nanoparticle (NP)-mediated delivery vehicle that effectively carries and protects siRNA in pediatric ependymoma (EP) and medulloblastoma (MB) cells. The delivery vehicle consists of gold NPs coated with a polymeric shell comprising polyethylene glycol (PG), chitosan and polyethyleneimine (Au-CP-PEI). NPs loaded with siRNA knocked down Ape1 expression by over 75% in both MB and EP cells. Further, this reduction in Ape1 expression is associated with an increase in DNA damage after irradiation. The results indicate that NP-associated delivery of siApe1 is a feasible approach to circumventing pediatric brain tumor resistance to radiation therapy...
April 27, 2017: Environmental Toxicology and Pharmacology
Sathesh Kumar Annamalai, Kantha D Arunachalam
The early biomarkers for the hematological, serological and histological alterations due to the effect of ½ and ¼ LC50 of (238)U in different organs in freshwater fish Pangasius sutchi for water-borne (238)U accumulation was investigated. The toxicological data due to (238)U accumulation on the hematological parameters such as hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and hematocrit (Hct) to evaluate the oxygen carrying capacity has been indicated as the secondary response of the organisms...
April 27, 2017: Environmental Toxicology and Pharmacology
Zhu Junbo, Yu Yongtao, Li Hongbo, Zheng Fenshuang, Lin Ruyun, Yang Chun'ai
OBJECTIVE: This study explored the effects of sucralfate intervention as a novel treatment for paraquat (PQ) poisoning in Sprague-Dawley (SD) rats. METHODS: After PQ poisoning, the SD rats were randomly divided into the PQ control group (treated with normal saline), the sodium bicarbonate (SB) treatment group, and the sucralfate (LTL) treatment group. Then, the rats were administered normal saline, sodium bicarbonate solution, or sucralfate suspension as an intervention by gastric lavage...
April 26, 2017: Environmental Toxicology and Pharmacology
Akiko Honda, Pratiti Home Chowdhury, Sho Ito, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Kayo Ueda, Hirohisa Takano
We investigated the synergic effects of components of particulate matter with aerodynamic diameters ≤2.5μm (PM2.5) on airway inflammation. Co-exposure to cadmium (Cd) and 9,10-phenanthrenequinone (9,10-PQ) additively/synergistically increased pro-inflammatory responses in airway epithelial cells, whereas co-exposure to Cd and phenanthrene resulted in no acceleration. These results suggest that the combination of metal and a quinone derivative can contribute to the exacerbation of respiratory diseases by PM2...
April 26, 2017: Environmental Toxicology and Pharmacology
Syed Baker, Tatiana Volova, Svetlana V Prudnikova, S Satish, Nagendra Prasad M N
Increment of technical knowledge has remarkably uplifted logical thinking among scientific communities to shape the theoretical concepts into near product-oriented research. The concept of nanotechnology has overwhelmed almost all forms of lives and has traded its applications in myriad fields. Despite rapid expansion of nanotechnology, sustainable competitions still do exist in the field of agriculture. In current scenario, agriculture is a manifestation demand to provide adequate nutrition for relentless growing global population...
April 23, 2017: Environmental Toxicology and Pharmacology
Harikiran Lingabathula, Narsimhareddy Yellu
The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase leakage, alkaline phosphatase, lipid peroxidation and total microprotein levels in BAL fluids after 1day, 1 week and 1 month post exposure periods. All the parameters were returned to normal values after 3 months post exposure period may be due to recovery...
April 22, 2017: Environmental Toxicology and Pharmacology
Haifa Othman, Mohamed Ammari, Kaïs Rtibi, Noura Bensaid, Mohsen Sakly, Hafedh Abdelmelek
The present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring. Ten Wistar albino pregnant rats were randomly assigned to two groups (n=5). The experimental group was exposed to a 2.45GHz WiFi signal for 2h a day throughout gestation period. Control females were subjected to the same conditions as treated group without applying WiFi radiations. After delivery, the offspring was tested for physical and neurodevelopment during its 17 postnatal days (PND), then for anxiety (PND 28) and motricity (PND 40-43), as well as for cerebral oxidative stress response and cholinesterase activity in brain and serum (PND 28 and 43)...
April 22, 2017: Environmental Toxicology and Pharmacology
Xinming Yun, Wenbing Rao, Ciying Xiao, Qingchun Huang
Leukemia threatens millions of people's health and lives, and the pesticide-induced leukemia has been increasingly concerned because of the etiologic exposure. In this paper, cytotoxic effect of emamectin benzoate (EMB), an excellent natural-product insecticide, was evaluated through monitoring cell viability, cell apoptosis, mitochondrial membrane potential and intracellular Ca(2+) concentration ([Ca(2+)]i) in leukemia K562 and Molt-4 cells. Following the exposure to EMB, cell viability was decreased and positive apoptosis of K562 and Molt-4 cells was increased in a concentration- and time- dependent fashion...
April 19, 2017: Environmental Toxicology and Pharmacology
Mariana Mardirosian, Flavia Bieczynski, Carlos Luquet, Carlos A Pérez, Guillermina Bongiovanni, Cecilia Lascano, Andrés Venturino
We assessed the toxicodynamics of As in developing Rhinella arenarum toad embryos and larvae exposed from fertilization to 0.01-10mgAsL(-1). We determined As content in toad embryos and larvae by X-ray fluorescence spectrometry. Toad embryos and larvae actively bioaccumulated As, reaching tissue concentrations more than one-thousand higher than control levels after 23d-exposure to 10mgAsL(-1). The bioconcentration factors also increased up to fifty times higher levels in toad larvae respect to media levels...
April 19, 2017: Environmental Toxicology and Pharmacology
Michaela Mináriková, Veronika Fojtikova, Eliška Vyskočilová, Jan Sedláček, Milan Šikut, Lucie Borek-Dohalska, Marie Stiborová, Marketa Martinkova
The aim of the study was to compare the adsorption ability of two adsorbent materials, namely diosmectite and activated charcoal towards selected model compounds that are most commonly involved in acute intoxication. Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenobarbital, ibuprofen, imipramine, carbamazepine, oxazepam, promethazine, and theophylline. Of the tested compounds, promethazine and imipramine were the most effectively adsorbed to diosmectite. Their adsorption to diosmectite (0...
April 17, 2017: Environmental Toxicology and Pharmacology
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