Hyun Ju Yoo, Yeogyeong Yi, Yoorha Kang, Su Jung Kim, Young-In Yoon, Phuc Huu Tran, Taewook Kang, Min Kyung Kim, Jaeseok Han, Eunyoung Tak, Chul-Soo Ahn, Gi-Won Song, Gil-Chun Park, Sung-Gyu Lee, Jae-Joong Kim, Dong-Hwan Jung, Shin Hwang, Nayoung Kim
We set up this study to understand the underlying mechanisms of reduced ceramides on immune cells in acute rejection (AR). The concentrations of ceramides and sphingomyelins were measured in the sera from hepatic transplant patients, skin graft mice and hepatocyte transplant mice by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Serum concentrations of C24 ceramide, C24:1 ceramide, C16:0 sphingomyelin, and C18:1 sphingomyelin were lower in liver transplantation (LT) recipients with than without AR...
November 30, 2023: Molecules and Cells