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International Journal of Infectious Diseases: IJID

Manfredi Gagliano, Costanza Marchiani, Giulia Bandini, Paolo Bernardi, Nicolas Palagano, Elisa Cioni, Martina Finocchi, Silvia Bellando Randone, Alberto Moggi Pignone
BACKGROUND: Spondylodiscitis are vertebral column infections whose incidence is rising due to an increase of the susceptible population and improved ascertainment. They have been associated with a wide range of microorganisms. Fungal spondylodiscitis is uncommon (0.5%-1.6%) and strongly associated with immunodepression and diabetes (Gouliouris et al., 2010). We present a rare case of Candida glabrata spondylodiscitis in a non neutropenic diabetic patient with the review of the literature...
January 12, 2018: International Journal of Infectious Diseases: IJID
Zuzanna Tyrakowska-Dadełło, Eugeniusz Tarasów, Dariusz Janusek, Anna Moniuszko-Malinowska, Joanna Zajkowska, Sławomir Pancewicz
BACKGROUND: Magnetic resonance imaging (MRI) changes in Tick-borne encephalitis (TBE) are nonspecific and pathophysiologic mechanisms leading to their formation remain unclear. This study aimed to investigate brain perfusion in TBE patients using dynamic susceptibility contrast (DSC) MR perfusion imaging. METHODS: MRI scans were performed in 12 patients in the acute phase, 3-5days after TBE diagnosis, with conventional MR images and DSC-MRI perfusion studies. Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak (TTP) parametric maps were created...
January 11, 2018: International Journal of Infectious Diseases: IJID
Emily Y Y Chan, Cheuk Pong Chiu, Gloria K W Chan
Complex emergencies remain as major threats to human well-being in the 21st century. More than 0.3 million Rohingya people in Myanmar, one of the most forgotten minority globally, had fled to the neighborhood communities, during the past decades. In recent crisis, the sudden influx within 3 months almost tripled the accumulated displaced population in Bangladesh. Using the Rohingya people in Bangladesh as a case context, this perspective paper synthesized evidence in published literature regarding what might be the key health risks associated with the five main health and survival supporting domains namely, water and sanitation, food and nutrition, shelter and non-food item, access to health service and information for the displaced living in camp settlements in Asia...
January 9, 2018: International Journal of Infectious Diseases: IJID
Marissa Gripenberg, Naveena Aloysia D'Cor, Maïna L'Azou, Grenville Marsh, Sophie Druelles, Joshua Nealon
OBJECTIVES: Hepatitis A is a viral liver disease whose prevalence is associated with low socio-economic and hygiene levels due to its fecal-oral transmission. Severity increases with age, and immunity is life-long. Decreased endemicity could result in increased age, and severity of cases. We conducted a literature review following PRISMA guidelines to describe changes in age-stratified hepatitis A seroprevalence in Asia Pacific countries from 1980-2016, and to identify literature gaps...
December 29, 2017: International Journal of Infectious Diseases: IJID
Hongzhi Gao, Xiang Ye, Ruowei Cai, Qiping Xu, Liping Liang, Shuji Izumo, Hui Qin Xing, Ryuji Kubota
We report a Chinese patient with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), who shows typical neurological symptoms of the disease. Since the presence of anti-HTLV-1 antibody had not been examined, HAM/TSP diagnosis of the patient has been delayed for the last four years. MRI examination revealed multiple spotty lesions in the cervical spinal cord, probably reflecting pathological changes known as perivascular lymphocytic infiltrations in the spinal cord. As this is the first case report of a HAM/TSP patient in China, we suggest that HTLV-1 serologic testing should be considered in patients with spastic paraparesis even in non-endemic areas of HTLV-1...
December 29, 2017: International Journal of Infectious Diseases: IJID
Maria Bonou, Chris J Kapelios, Michael Samarkos, George Benetos, Maria Tampaki, Nikoletta Pianou, Alexandros Georgakopoulos, Ioannis Moyssakis, Constantinos Anagnostopoulos, John Barbetseas
No abstract text is available yet for this article.
December 22, 2017: International Journal of Infectious Diseases: IJID
Theodoros Retsas, Klaus Huse, Lazaros-Dimitrios Lazaridis, Niki Karampela, Michael Bauer, Matthias Platzer, Virginia Kolonia, Eirini Papageorgiou, Evangelos J Giamarellos-Bourboulis, George Dimopoulos
OBJECTIVES: Several manuscripts provide conflicting results for the role of single nucleotide polymorphisms (SNPs) at the promoter region of TNF for susceptibility to sepsis. Former manuscripts were based on previous sepsis definitions. We investigated the influence of TNF haplotypes on sepsis development using the new Sepsis-3 definitions. METHODS: DNA was isolated from patients suffering from infection and systemic inflammatory response syndrome; haplotyping was performed for six SNPs of TNF...
December 20, 2017: International Journal of Infectious Diseases: IJID
Alaa Badawi, Seung Gwan Ryoo, Danitsa Vasileva, Sahar Yaghoubi
BACKGROUND: Epidemiologic evidence suggests that patients with chikungunya virus (CHIKV) infection may be at risk of severe disease complications when they also have comorbidities such as obesity, diabetes, cardiac diseases, and/or asthma. However, the prevalence of these co-existing medical conditions in severe CHIKV cases has not been systematically reported. OBJECTIVE: The aim of the present study is to conduct a systematic review and meta-analysis to describe the prevalence of chronic comorbidities in CHIKV and evaluate their possible contributions to disease severity...
December 19, 2017: International Journal of Infectious Diseases: IJID
Isaí Medina-Piñón, Martín Wah-Suárez, Luis Arturo Acosta-Calderón, Javier Ramos-Jiménez
No abstract text is available yet for this article.
December 15, 2017: International Journal of Infectious Diseases: IJID
Rosca Elena Cecilia, Simu Mihaela
Trichinosis is a parasitic disease that, due to variable clinical syndromes, is often underrecognized. We present the case of a patient with eosinophilia, focal neurological signs and multiple bilateral brain lesions, distributed mainly in the border zones. The diagnostic workup revealed neurotrichinosis, which should be suspected even without a clear history of consumption of poorly cooked meat.
December 15, 2017: International Journal of Infectious Diseases: IJID
Isaac Zentner, Chawangwa Modongo, Nicola M Zetola, Jotam G Pasipanodya, Shashikant Srivastava, Scott K Heysell, Stellah Mpagama, Hans P Schlect, Tawanda Gumbo, Gregory P Bisson, Christopher Vinnard
OBJECTIVES: Pyrazinamide is a key drug in the first-line tuberculosis treatment regimen, with a potent sterilizing effect. Although low pyrazinamide peak serum concentrations (Cmax) are associated with poor treatment outcomes, many resource-constrained settings do not have sufficient laboratory capacity to support therapeutic drug monitoring. Our objective was to determine whether a colorimetric test of urine can identify tuberculosis patients with adequate pyrazinamide exposures, as defined by the serum Cmax above a target threshold...
December 15, 2017: International Journal of Infectious Diseases: IJID
Silva P Kouyoumjian, Houssine El Rhilani, Amina Latifi, Amina El Kettani, Hiam Chemaitelly, Kamal Alami, Aziza Bennani, Laith J Abu-Raddad
OBJECTIVES: We aimed to assess HIV modes of exposure in Morocco at the national level, and for Souss Massa Draa, the most affected region by HIV. We further aimed to assess the impact of different scenarios of select intervention packages. METHODS: Modes of Transmission Model was adapted and used, and was parameterized by quality bio-behavioral surveillance data among key populations, routine data sources, and literature reviews. RESULTS: Nationally in 2013, the largest number of new infections occurred among clients of female sex workers (FSWs) (25%; 95% confidence interval-CI=14-37%), followed by men who have sex with men (MSM) (22%; 95% CI=12-35%), HIV sero-discordant couples (22%; 95% CI=12-34%), FSWs (11%; 95% CI=6-18%), and people who inject drugs (5%; 95% CI=2-9%)...
December 15, 2017: International Journal of Infectious Diseases: IJID
Zheng Jie Marc Ho, Cynthia Bin Eng Chee, Rick Twee-Hee Ong, Li Hwei Sng, Woei Ling Justine Peh, Alex R Cook, Li Yang Hsu, Yee Tang Wang, Han Fang Koh, Vernon Jian Ming Lee
OBJECTIVE: Between February 2012 and May 2016, six residents of an 11-storey apartment block were diagnosed with MDR-TB. Based on initial tests, all isolates had similar genotypic profiles, although there were no identifiable epidemiological transmission patterns between three cases. We present findings from the cluster investigation and results of a mass screening exercise. DESIGN: Free voluntary TB screening was offered to past and current residents of the apartment block, comprising an interview, Chest X-Ray, and Interferon Gamma Release Assay or Tuberculin skin test...
December 15, 2017: International Journal of Infectious Diseases: IJID
Yutaka Tojo, Satoru Yanagisawa, Eisaku Miyauchi, Masakazu Ichinose
No abstract text is available yet for this article.
December 15, 2017: International Journal of Infectious Diseases: IJID
José Moreira, Rodolfo Castro, Cristiane Lamas, Sayonara Ribeiro, Beatriz Grinsztejn, Valdiléa G Veloso
BACKGROUND: Hyperglycemia occurs in tuberculosis (TB), but the long-term impact is unknown. We estimated the prevalence of hyperglycemia and compared the TB treatment outcomes and 1-year mortality rate according to the glycemic status noted during TB treatment. METHODS: We conducted a retrospective cohort analysis of adult patients who had TB and HIV co-infection and started receiving TB treatment at the Instituto Nacional de Infectologia Evandro Chagas, Brazil, between 2010-2015...
December 15, 2017: International Journal of Infectious Diseases: IJID
Tat Trung Ngo, Van Tong Hoang, Thi Lien Tran, Van Son Trinh, Thi Thanh Huyen Tran, Thanh Quyen Dao, Quoc Hoan Phan, Christian G Meyer, Huu Song Le
INTRODUCTION: For the identification of bacterial pathogens, blood culture is still the gold standard diagnostic method. However, several disadvantages apply to blood cultures, such as time and rather large volumes of blood sample required. We have previously established an optimised multiplex real-time PCR method in order to diagnose bloodstream infections. MATERIAL AND METHODS: In the present study, we evaluated the diagnostic performance of this optimised multiplex RT-PCR in blood samples collected from 110 septicaemia patients enrolled at the 108 Military Central Hospital, Hanoi, Vietnam...
December 15, 2017: International Journal of Infectious Diseases: IJID
José A Del Campo, Manuel Parra-Sánchez, Blanca Figueruela, Silvia García-Rey, Josep Quer, Josep Gregori, Samuel Bernal, Lourdes Grande, José C Palomares, Manuel Romero-Gómez
BACKGROUND: The effectiveness of new generation of hepatitis C treatments named DAAs (direct-acting antiviral agents) is conditioned by the genotype, subtype and resistance associated substitutions to DAAs present in individual patients. The aim of this study is the evaluation of a massive sequencing platform for the analysis of genotypes and subtypes of hepatitis C and therapy optimization. METHODS: We have analyzed 84 HCV patients. Routine genotyping methodology for hepatitis C virus used in our center (VERSANT HCV Assay, LiPA), was compared with deep sequencing platform (454/GS-Junior and Illumina MiSeq)...
December 15, 2017: International Journal of Infectious Diseases: IJID
Silveira Filho Luiz Gonzaga da, Correia Dalmo
Cranial computed tomography (CT) is still valuable in the identification of opportunistic pathologies (OP) in AIDS' patients from low-income countries. Delayed iodinated contrast media (ICM) CT-images have the potential ability to better demonstrate inflammatory-infectious or neoplastic OP.
December 13, 2017: International Journal of Infectious Diseases: IJID
Renske REMLabordus-van Helvoirt, Miranda MMLvan Rijen, Peter Pvan Wijngaarden
In several countries, including the Netherlands, a search and destroy policy is part of the standard of care. Due to this policy and restrictive use of antibiotics the prevalence of MRSA carrier state and infections in The Netherlands is among the lowest in the world. In the Netherlands health care workers with a MRSA carrier state are not allowed to carry out work involving direct patient care. This means that treatment failure can have major implications for their working career. Despite repeated treatments according to guidelines, eradication of MRSA fails in a minority of cases...
December 12, 2017: International Journal of Infectious Diseases: IJID
Linlin Yan, Yanhui Chen, Jiyuan Zhou, Hong Zhao, Henghui Zhang, Guiqiang Wang
OBJECTIVES: Circulating cell-free DNA (cfDNA) is a potential biomarker for tumor diagnosis. Hepatocyte damage is characteristic component of the pathobiology of hepatocellular carcinoma (HCC), which would be expected to result in substantial leakage of cfDNA into the circulation. However, the diagnostic value of cfDNA levels for HCC remains unclear. METHODS: Plasma samples were collected from 24 HCC patients and 62 HBV-related liver fibrosis patients. Plasma cfDNA levels was quantified by Qubit method...
December 8, 2017: International Journal of Infectious Diseases: IJID
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