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International Journal of Infectious Diseases: IJID

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https://www.readbyqxmd.com/read/28416440/inhibition-of-the-pi3k-akt-mtor-signaling-pathway-in-t-lymphocytes-in-patients-with-active-tuberculosis
#1
XueXuan Zhang, TengYi Huang, Ying Wu, WenGuang Peng, HanBin Xie, MeiChen Pan, HuanBin Zhou, BoZhi Cai, YingE Wu
OBJECTIVES: To investigate PI3K-Akt-mTOR signaling pathway changes and the proliferation of FoxP3(+)Treg cells in patients with active tuberculosis. METHODS: We isolated PBMCs and CD4(+)CD25(+)FoxP3(+) Treg cells from peripheral blood collected from patients with active tuberculosis and healthy controls. We compared the proportion and MFI of PI3K-Akt-mTOR pathway components and PTEN by flow cytometry using specific cell-surface and intracellular markers. Moreover, we detected the specific secretory proteins ESAT-6 and Ag85B, cytokines IL-10, TGF-β1 and IL-35 in serum by ELISA...
April 14, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28412410/probable-pulmonary-blastomyomycocis-in-an-immunocompetent-person
#2
Dan Zhu, Hui Chen, Long Yu
The current case report presents a 29-year old man, who worked as a hotel guard in a city, China. The patient had fever and dry cough before and after hospitalization. Chest X-ray and CT revealed nodular and patchy lesions in both lower lungs. There were no abnormal findings in the examination of sputum and bronchoalveoular lavage fluid (BALF). He was diagnosed as pulmonary blastmycosis by histological examination of lung biopsy and treated with fluconazole. Follow-up chest CT examination demonstrated that the patient was recovered through appropriate antifungal treatment...
April 12, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28412409/development-of-monoclonal-antibodies-against-sj29-and-its-possible-application-for-schistosomiasis-diagnosis
#3
Cui-Ping Ren, Quan Liu, Feng-Chun Liu, Feng-Yu Zhu, Shi-Xiang Cui, Zhen Liu, Wen-Da Gao, Miao Liu, Yong-Sheng Ji, Ji-Jia Shen
OBJECTIVE: Timely Schistosoma japonicum detection improves outcomes in schistosomiasis. Here, we established a double antibody sandwich ELISA to detect Schistosoma japonicum. METHODS: Sj29 polyclonal and monoclonal antibodies were developed and identified. A Sj29 double antibody sandwich ELISA was evaluated. RESULTS: Assay sensitivity for detecting Schistosoma japonicum circulating antigen Sj29 was 76.7% (23/30), 54.5% (18/33) and 50.0% (18/36) in patients with acute, chronic and advanced schistosomiasis...
April 12, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28412408/breast-abscess-due-to-bacillus-calmette-gu%C3%A3-rin
#4
Aurélien Dinh, Clara Duran, Benjamin Davido, Ruxandra Calin, Anne-Laure Roux, Jérôme Salomon
No abstract text is available yet for this article.
April 12, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28412407/prevalence-molecular-epidemiology-and-intra-hospital-acquisition-of-klebsiella-pneumoniae-strains-producing-carbapenemases-in-an-italian-teaching-hospital-from-january-2015-to-september-2016
#5
Andrea Bartolini, Monica Basso, Elisa Franchin, Nicola Menegotto, Anna Ferrari, Ettore De Canale, Samantha Andreis, Renzo Scaggiante, Stefania Stefani, Giorgio Palù, Saverio Giuseppe Parisi
OBJECTIVES: We described Klebsiella pneumoniae producing carbapenemases (CPKP) spread from 01/01/2015 to 13/09/16 in a tertiary level hospital. METHODS: The first positive surveillance rectal swab (SRS) or clinical sample (CS) collected in medical department (MD), surgical department (SD) and intensive care department (ICD) was included in the study. A validated in-house Real-Time PCR method was used to detect carbapenemases, multilocus sequence typing (MLST) was used for further characterization of the strains...
April 12, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28419820/community-acquired-infections-among-the-refugees-leading-to-intensive-care-unit-admissions-in-turkey
#6
Mediha Turktan, Oznur Ak, Hakan Erdem, Dilek Ozcengiz, Sally Hargreaves, Safak Kaya, Emre Karakoc, Ozlem Ozkan-Kuscu, Gunay Tuncer-Ertem, Recep Tekin, Handan Birbicer, Gul Durmus, Canan Yilmaz, Funda Kocak, Edmond Puca, Jordi Rello
OBJECTIVES: Data on the impact of refugees on Intensive Care Units (ICUs) are lacking in the literature, in particular for community-acquired (CA) infectious diseases, for which they are known to be at higher risk. We did a descriptive, multicenter study to analyze CA infections among refugee patients requiring ICU admission. METHODS: Inclusion criteria were adult refugee patients admitted to an ICU due to CA infections. Anonymized data were collected between January 1, 2010 and December 30, 2015 across 10 referral centers...
April 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28408253/humanized-chimeric-mouse-models-of-hepatitis-b-virus-infection
#7
REVIEW
Suwan Sun, Jun Li
Hepatitis B virus (HBV) infection is associated with an increased risk of hepatic cirrhosis, hepatocellular carcinoma, fulminant hepatitis and end-stage hepatic failure. Despite the availability of anti-HBV therapies, HBV infection remains a major global public health problem. Developing an ideal animal model of HBV infection to clarify the details of the HBV replication process, the viral life cycle, the resulting immunoresponse and the precise pathogenesis of HBV is difficult because HBV has an extremely narrow host range and almost exclusively infects humans...
April 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28408252/israeli-spotted-fever-in-sicily-description-of-two-cases-and-minireview
#8
REVIEW
Claudia Colomba, Marcello Trizzino, Anna Giammanco, Celestino Bonura, Danilo Di Bona, Manlio Tolomeo, Antonio Cascio
Mediterranean spotted fever (MSF) is endemic in Italy where Rickettsia conorii subsp. conorii was thought to be the only pathogenic rickettsia and Rhipicephalus sanguineus the vector and main reservoir. R. conorii subsp. israelensis, which belongs to the R. conorii complex, is the agent of Israeli spotted fever (ISF); apart from Israel, it has also been found in Italy (Sicily and Sardinia) and in different regions of Portugal. We describe here two severe cases of ISF which occurred in otherwise healthy Italian adults...
April 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28408251/a-34-year-old-obese-woman-with-rash-finger-swelling-and-fever
#9
Na Huo, Zhao Wu, Xiaoqin Dong, Feng Li, Nong Lin, He Wang, Hong Zhao
Disseminated tuberculosis first presenting as cutaneous lesion is uncommon and difficult to diagnose on account of its divers clinical forms. We present a 34-year-old obese woman with rash, finger swelling and fever. The patient was firstly manifested by fever and mass in palm and finger, gradually involving multisystems injury. She was diagnosed with disseminated tuberculosis in consideration of multiple system involvement, imaging characteristics, tuberculous granuloma in dermis and positive result of Mycobacterium culture...
April 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28408250/international-society-for-infectious-diseases-position-statement-on-the-march-for-science-april-22-2017
#10
EDITORIAL
Jonathan Cohen, Marc Mendelson
No abstract text is available yet for this article.
April 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28392319/diagnostic-accuracy-of-routine-blood-examinations-and-csf-lactate-level-for-post-neurosurgical-bacterial-meningitis
#11
Yang Zhang, Xiong Xiao, Junting Zhang, Zhixian Gao, Nan Ji, Liwei Zhang
OBJECTIVE: To evaluate the diagnostic accuracy of routine blood examinations and Cerebrospinal Fluid (CSF) lactate level for Post-neurosurgical Bacterial Meningitis (PBM) at a large sample-size post-neurosurgical patients. METHODS: The diagnostic accuracies of routine blood examinations and CSF lactate level to distinguish between PAM and PBM were evaluated with the values of the Area Under the Curve of the Receiver Operating Characteristic (AUC-ROC) by retrospectively analyzing the datasets of post-neurosurgical patients in the clinical information databases...
April 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28392318/the-performance-of-the-tbag-pha-ratio-in-the-diagnosis-of-active-tb-disease-in-immunocompromised-patients
#12
Munyemana Jean Bosco, Hongyan Hou, Lie Mao, Xiaohui Wu, Kreeti Devi Ramroop, Yanfang Lu, Liyan Mao, Yu Zhou, Ziyong Sun, Feng Wang
OBJECTIVES: The results of the T-SPOT.TB (T-SPOT) assay are reduced in immunocompromised patients with active tuberculosis (ATB), and it is difficult for using T-SPOT results to distinguish ATB from latent tuberculosis infection (LTBI) in this condition. The aim of this study was to determine the performance of the TBAg/PHA ratio in T-SPOT assay in the diagnosis of ATB in immunocompromised patients. METHODS: One hundred and forty three immunocompromised ATB patients and 124 LTBI individuals were diagnosed according to conventional tests and T-SPOT assay...
April 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28392317/novel-mutations-in-gyra-and-parc-among-shigella-sonnei-strains-from-jiangsu-province-of-china-2002-2011
#13
Bing Gu, Ting-Ting Qin, Wen-Ting Fan, Ru-Ru Bi, Ying Chen, Ying Li, Ping Ma
BACKGROUND & OBJECTIVES: To investigate fluoroquinolone resistance and associated mechanism of Shigella sonnei isolates in Jiangsu Province of China between 2002 and 2011. METHODS: All 337 unduplicated S. sonnei isolates were collected from hospitals in Jiangsu Province from January 2002 to December 2011. Fluoroquinolone susceptibility was characterized by Kirby-Bauer disk diffusion method and direct nucleotide sequencing of genes of the quinolone resistance determining regions were conducted...
April 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28392316/prevalence-of-latent-mycobacterium-tuberculosis-infection-ltbi-in-saudi-arabia-population-based-survey
#14
Hanan H Balkhy, Kamel El Beltagy, Aiman El-Saed, Badr Aljasir, Abdulhakeem Althaqafi, Adel F Alothman, Mohammad Alshalaan, Hamdan Al-Jahdali
BACKGROUND: The annual risk of tuberculosis infection (ARTI) data in Saudi Arabia has never been updated since 1993. OBJECTIVES: To estimate the prevalence of latent TB infection (LTBI) and ARTI in a population-based sample in Saudi Arabia using Tuberculin skin test (TST) and QuantiFERON TB Gold in tube (QFT-GIT) test. METHODS: A population-based cross sectional study was conducted between July 2010 and March 2013. Participants were randomly selected from the population served by the primary healthcare centers of the Ministry of National Guard Health Affairs in Riyadh, Jeddah, Alhassa and Dammam, Saudi Arabia...
April 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28392315/clinical-efficacy-of-ceftazidime-avibactam-versus-other-active-agents-for-the-treatment-of-bacteremia-due-to-carbapenemase-producing-enterobacteriaceae-in-hematologic-patients
#15
Juan J Castón, Isabel Lacort, Pilar Martín-Dávila, Belén Loeches, Salvador Tabares, Liz Temkin, Julián Torre-Cisneros, José R Paño
OBJECTIVES: The primary objective was to describe clinical features, treatment and outcomes in patients with carbapenemase-producing Enterobacteriaceae (CPE) bacteremia. Additionally, patients treated with ceftazidime/avibactam (study group) were compared to the rest of the patients (comparator group) to determine the influence of the treatment in both crude mortality and clinical cure. METHODS: Multicenter and retrospective study that included patients with hematologic malignancies who had CPE bacteremia...
April 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28359826/response-to-socio-political-prescriptions-for-latent-tuberculosis-infection-are-required-to-prevent-reactivation-of-tuberculosis
#16
LETTER
Greg J Fox, Claudia C Dobler, Ben J Marais, Justin T Denholm
The importance of addressing the conditions that predispose individuals and populations to develop tuberculosis is increasingly being recognized. Accurate quantification of the protective effect of preventive therapy and the provision of pragmatic guidance for clinical care and public health interventions is important. However, this approach must be nested within a socio-political context that addresses associated disadvantage and inequality.
March 27, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28347741/corrigendum-to-global-correlates-of-emerging-zoonoses-anthropogenic-environmental-and-biodiversity-risk-factors-int-j-infect-dis-53-supplement-december-2016-21
#17
T Allen, K Murray, C Zambrana-Torrelio, S Morse, C Rondinini, M di Marco, K Olival, P Daszak
No abstract text is available yet for this article.
March 25, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28347852/first-report-of-human-parechovirus-type-3-infection-in-a-pregnant-woman
#18
Makiko Shinomoto, Tatsuya Kawasaki, Takuya Sugahara, Keiko Nakata, Tomoya Kotani, Hidetaka Yoshitake, Kento Yuasa, Masashi Saeki, Yasuhiro Fujiwara
Human parechovirus type 3 (HPeV3) can cause serious conditions in neonates, such as sepsis and encephalitis, but data for adults are lacking. The case of a pregnant woman with HPeV3 infection is reported herein. A 28-year-old woman at 36 weeks of pregnancy was admitted because of myalgia and muscle weakness. Her grip strength was 6.0kg for her right hand and 2.5kg for her left hand. The patient's symptoms, probably due to fasciitis and not myositis, improved gradually with conservative treatment, however labor pains with genital bleeding developed unexpectedly 3 days after admission...
March 24, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28347851/implementation-of-an-antibiotic-checklist-increased-appropriate-antibiotic-use-in-the-hospital-on-aruba
#19
Frederike Vera van Daalen, Anouk Lagerburg, Jaclyn de Kort, Elena Sànchez Rivas, Suzanne Eugenie Geerlings
OBJECTIVES: No interventions have yet been implemented to improve antibiotic use on Aruba. In the Netherlands, the introduction of an antibiotic checklist resulted in more appropriate antibiotic use in nine hospitals. The aim of this study was to introduce the antibiotic checklist on Aruba, test its effectiveness, and evaluate the possibility of implementing this checklist outside the Netherlands. METHODS: The antibiotic checklist includes seven quality indicators (QIs) that define appropriate antibiotic use...
March 24, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28347850/clinical-features-and-treatment-of-patients-with-vibrio-vulnificus-infection
#20
Wei Yu, Xiaomin Shen, Hongying Pan, Tingting Xiao, Ping Shen, Yonghong Xiao
OBJECTIVES: Infections with Vibrio vulnificus are commonly fatal, and the speed and accuracy of diagnosis and treatment is directly linked to mortality. The main aims of this study were to investigate the clinical characteristics of six patients with V. vulnificus infections retrospectively and to determine the effect of treatment with tigecycline (TGC) alone compared with doxycycline plus ceftazidime (DOX/CAZ). METHODS: The medical records of patients were reviewed...
March 24, 2017: International Journal of Infectious Diseases: IJID
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