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International Journal of Infectious Diseases: IJID

Joana Calado, Rita Castro, Ângela Lopes, Maria José Campos, Miguel Rocha, Filomena Pereira
OBJECTIVES: To analyze the susceptibility of Neisseria gonorrhoeae isolates to penicillin (Pen), cefixime (Cfm), ceftriaxone (Cro), tetracycline (Tet), ciprofloxacin (Cip), azithromycin (Azm) and spectinomycin (Spt). To verify the presence of mutations in resistant genes. METHODS: Antibiotic susceptibility testing was carried out by Etest method in 30N. gonorrhoeae isolates collected from MSM population. PCR and DNA sequencing were performed to identify mutations within penA, mtrR, gyrA and parC genes in intermediate or full resistance isolates...
November 6, 2018: International Journal of Infectious Diseases: IJID
Jiahui Zhang, Na Cui, Yun Long, Hao Wang, Wen Han, Yuanfei Li, Meng Xiao
OBJECTIVES: This study aimed to investigate the distinguishing ability of lymphocyte subtyping for Invasive candidiasis (IC) diagnosis and prognosis in non-neutropenic critically ill patients. METHODS: We assessed the quantitative changes in key parameters of lymphocyte subtyping at the onset of clinical signs of infection in non-neutropenic critically ill patients and their potential influence on diagnosis and outcome of IC. The primary outcome was 28-day mortality...
November 3, 2018: International Journal of Infectious Diseases: IJID
Juan David Ramírez, Giovanny Herrera, Carlos Muskus, Claudia Mendez, María Clara Duque, Robert Butcher
AIM: Here, we evaluate the ddPCR platform using an evaluated qPCR-based diagnostic assay for the detection of Leishmania infection in Cutaneous Leishmaniasis patients. METHODS: A standard curve of cultured Leishmania parasite material and clinical samples of CL patients were tested with ddPCR to determine the analytical and diagnostic performance. RESULTS: The limit of detection of the assay on the ddPCR platform was much higher than the published limit of detection of the same assay on the qPCR platform (100 vs 1 parasites/mL, respectively)...
November 3, 2018: International Journal of Infectious Diseases: IJID
Kin Wang To, Shui Shan Lee
Pre-exposure prophylaxis (PrEP) for HIV is approved for HIV prevention in many western countries. PrEP is not yet widely available in South East Asia. Awareness of PrEP among MSM in the region is very variable in different countries. While willingness of PrEP uptake is closely related to the extent of awareness, it is largely affected by factors at the individual level, e.g. financial status, risk perception, understanding of PrEP and convenience. Removal of social stigmata and secure data confidentiality can improve willingness of uptake...
November 2, 2018: International Journal of Infectious Diseases: IJID
J B Te Riele, V Buser, G Calligaro, A Esmail, G Theron, M Lesosky, K Dheda
BACKGROUND: Data about the relationship between chest radiographs and sputum bacillary load, with treatment outcomes, in patients with extensively drug-resistant tuberculosis (XDR-TB) from HIV/TB endemic settings are limited. METHODS: Available chest radiographs from 97 South African XDR-TB patients, at the time of diagnosis, were evaluated by two independent readers using a validated scoring system. Chest radiograph findings were correlated with baseline sputum bacillary load (smear-grade and culture time-to-positive in MGIT), and prospectively ascertained clinical outcomes (culture conversion and all-cause mortality)...
November 2, 2018: International Journal of Infectious Diseases: IJID
Han Xia, Na Zhao, Lu Zhao, Yujuan Wang, Wang Zhao, Zhiming Yuan
OBJECTIVES: Banna virus (BAV) is classified in the genus Seadornavirus within the Reoviridae family and considered to be an emerging pathogen. We aimed to develop a rapid and simple molecular detection approach for all BAV subgroups in isothermal conditions. METHOD: A set of six specific primers was designed to target the segment 12 of BAV, and the reverse transcription-loop mediated isothermal amplification (RT-LAMP) assay was developed and compared with conventional RT-PCR method RESULTS: The amplification of the RT-LAMP assay can be obtained within 40min at 65°C...
November 2, 2018: International Journal of Infectious Diseases: IJID
Arati Mane, Suchit Kamble, Manish Kumar Singh, Manisha Ratnaparakhi, Amit Nirmalkar, Raman Gangakhedkar
BACKGROUND: Our aim was to estimate the seroprevalence of spotted fever group (SFG) and typhus group (TG) rickettsiae among individuals with acute febrile illness (AFI) in the scrub typhus endemic Gorakhpur district, India; one of the worst affected by annual seasonal acute encephalitis syndrome (AES) outbreaks. METHODS: Antibodies against SFG and TG rickettsiae and the associated risk factors were determined in 294 individuals presenting with AFI, encountered during a community based survey conducted during AES outbreak period October-November 2016...
November 1, 2018: International Journal of Infectious Diseases: IJID
Evgeniya Sovershaeva, Tinei Shamu, Tom Wilsgaard, Tsitsi Bandason, Trond Flægstad, David Katzenstein, Rashida A Ferrand, Jon Odland
OBJECTIVE: To investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare. METHODS: Children (0-19 years) and adults (>19years) starting ART between 2013 and 2015 were followed for a median of 2.8 and 2.7 years respectively. The incidence rates of virological failure (VF), low level viraemia (LLV) and viral blips were assessed and the predictors of viraemia were determined using logistic and parametric survival regression...
October 31, 2018: International Journal of Infectious Diseases: IJID
Jiye Fu, Chu Jiang, Juguang Wang, Run Cai, Wei Cheng, Lifei Shi, Fan Zhang, Zhilan Xu, Xing Yan
BACKGROUND: Since the National Action Plan for Measles Elimination 2006-2012 was released in 2006, China has entered into an era of accelerated measles elimination. Despite substantial decline, measles outbreak continued to occur mainly in non-targeted population, in particular health workers due to occupational exposure. We investigated a measles outbreak in a Chinese medicine hospital, Beijing, in March 2018. METHODS: Descriptive analysis was performed on epidemiology of the outbreak, clinical and laboratory evaluations, vaccination status of cases, and public health response...
October 31, 2018: International Journal of Infectious Diseases: IJID
Mariam M Mirambo, Said Aboud, Majigo Mtebe, Uwe Groβ, Stephen E Mshana
OBJECTIVE: This study investigated the adverse pregnancy outcomes among pregnant women with acute Rubella infections in the city of Mwanza, Tanzania. METHODS: A longitudinal study was conducted between 2014 and 2016 among pregnant women attending antenatal clinics. Women were screened for Rubella IgG and IgM antibodies using enzyme immunoassay (EIA). IgM seropositive pregnant women were followed until the end of the pregnancy to determine Congenital Rubella Syndrome, congenital infections and other pregnancy outcomes...
October 31, 2018: International Journal of Infectious Diseases: IJID
Yibeltal Assefa, Charles F Gilks, Judith Dean, Betru Tekle, Meskele Lera, Taye Tolera Balcha, Yimam Getaneh, Wim Van Damme, Peter S Hill
BACKGROUND: Ethiopia has adopted the global plan to end the epidemic of HIV/AIDS. We aimed to assess the progress toward achieving this plan. METHODS: A review and analysis of national population-based surveys, surveillances and routine program data was executed. Data analysis was conducted using Excel 2016 and Stata 14: Data Analysis and Statistical Software, StataCorp LP, College Station, Texas, USA. FINDINGS: Between 2011 and 2016, the number of HIV-related deaths dropped by 58% while that of new HIV infections dropped by only 6%...
October 31, 2018: International Journal of Infectious Diseases: IJID
Shui Shan Lee, Eskild Petersen
No abstract text is available yet for this article.
October 30, 2018: International Journal of Infectious Diseases: IJID
Luigi Brunetti, Seung-Mi Lee, Ronald G Nahass, David Suh, Benjamin Miao, John Bucek, Dongwon Kim, Ok-Kyu Kim, Dong-Churl Suh
OBJECTIVES: Levofloxacin and amiodarone are both known to prolong the QT interval. This study was conducted to estimate the risk of cardiac events in patients receiving concomitant levofloxacin and amiodarone. METHODS: The study included patients who were admitted to a large academic community medical center from 1/2012 to 12/2015 and received both levofloxacin and amiodarone at some point during their hospitalization. Patients received concomitant or non-concomitant levofloxacin and amiodarone during hospitalization...
October 29, 2018: International Journal of Infectious Diseases: IJID
Marta Kicia, Magdalena Szydłowicz, Kamil Cebulski, Katarzyna Jakuszko, Paweł Piesiak, Aneta Kowal, Bohumil Sak, Magdalena Krajewska, Andrzej B Hendrich, Martin Kváč, Żaneta Kopacz
OBJECTIVES: Encephalitozoon spp. and Enterocytozoon bieneusi are intracellular parasitic fungi from the phylum Microsporidia, which initially localize to intestine. As opportunistic pathogens, especially Encephalitozoons can disseminate, among others to the respiratory tract. Patients under life-long immunosuppression are at higher risk of such infections, mostly symptomatic. METHODS: Sputum samples and bronchial washings from 72 renal transplant recipients and 105 patients with various respiratory diseases were screened for Encephalitozoon spp...
October 26, 2018: International Journal of Infectious Diseases: IJID
M Montero, M Mir, E Sulleiro, J L Avalos Esquivel, E García López, D Molina-Morant, I López Montesinos, L Sorlí, G Veliz Espinosa, E Mounteis Oliva, M Crespo, I Monge, J P Horcajada, S Grau, J Pascual
There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was successfully treated with larger benznidazole doses than are recommended, in order to reach therapeutically effective concentrations in the brain.
October 25, 2018: International Journal of Infectious Diseases: IJID
Ralph Huits, Dorien Van Den Bossche, Kaat Eggermont, Erica Lotgering, Anne-Marie Feyens, Idzi Potters, Jan Jacobs, Marjan Van Esbroeck, Lieselotte Cnops, Emmanuel Bottieau
BACKGROUND: The incidence rate of Zika virus (ZIKV) infection in travelers from non-endemic areas to the Americas during the ZIKV outbreak in 2016 is unknown. METHODS: We prospectively recruited Belgian adults, who planned to travel to South America (SAM), Central America (CAM) and the Caribbean (CAR), to study the incidence and characteristics of ZIKV. We collected demographic data and sera at baseline. We trained participants to collect capillary blood on filter paper (BFP)...
October 24, 2018: International Journal of Infectious Diseases: IJID
Admire S Murongazvombo, Riitta A Dlodlo, Hemant Deepak Shewade, Valerie Robertson, Susumu Hirao, Elijah Pikira, Cedric Zhanero, Rachael K Taruvinga, Precious Andifasi, Cremence Tshuma
OBJECTIVES: To describe the pre-diagnosis and pre-treatment loss to follow-up (LTFU) in the TB care cascade in Guruve (2015-16), a rural district in Zimbabwe. DESIGN: Guruve has 19 rural health centres (RHCs) and one district hospital. In this cohort study, persons (≥15years) with presumptive pulmonary TB were tracked from the facility presumptive TB registers to the laboratory registers and if laboratory diagnosed, to the district TB register (contains details of all TB patients registered for treatment)...
October 24, 2018: International Journal of Infectious Diseases: IJID
Qianqian Fan, Wai-Kit Ming, Wai-Ying Yip, Joyce H S You
OBJECTIVE: Hong Kong is a high-income city of China with intermediate tuberculosis (TB) burden and 1% of TB cases were multidrug-resistant tuberculosis (MDR-TB). We aimed to examine the potential cost-effectiveness of adding bedaquiline or delamanid to background regimen (BR) for treatment of MDR-TB in Hong Kong. METHODS: A decision-analytic model was designed to simulate outcomes, over a 10-year time horizon, of MDR-TB patients treated with bedaquiline plus BR (B-BR), delamanid plus BR (D-BR) or BR alone...
October 17, 2018: International Journal of Infectious Diseases: IJID
Laure Stella Ghoma Linguissi, Violaine Lucaccioni, Matthew Bates, Alimuddin Zumla, Francine Ntoumi
The Human Immunodeficiency Virus (HIV) epidemic continues to be a major global public health issue. Since 2012, there has been a paucity of information from the RoC on HIV incidence and prevalence rates, national HIV program effectiveness, HAART rollout, patient adherence to treatment, operational and basic science research studies on HIV/AIDS, and donor funding and its impact from the RoC. We conducted a review of the existing literature on HIV in the RoC focused our review on prevalence trends, effectiveness of current HIV national program, HAART rollout, patient adherence to antiretrovirals (ARVs), resistance to ARVs, the cost of treatment and operational issues affecting HIV/AIDS programs in the RoC...
October 17, 2018: International Journal of Infectious Diseases: IJID
Neha Rastogi, Surbhi Khurana, Balaji Veeraraghavan, Francis Yesurajan Inbanathan, Suresh Kumar Rajamani Sekar, Deepak Gupta, Keshav Goel, Ashish Bindra, Navdeep Sokhal, Ashutosh Panda, Rajesh Malhotra, Purva Mathur
OBJECTIVE: This study describes a detailed epidemiological and molecular characterization of an outbreak of Burkholderia cepacia at a neuro-trauma intensive care unit of a level-1 trauma centre. It emphasizes stringent infection control interventions taken to successfully curb this outbreak. METHODS: Clinical and microbiological data was reviewed for the patients, who had more than one blood culture that grew B. cepacia. Bacterial identification and antimicrobial susceptibility was done using automated VITEK II systems...
October 17, 2018: International Journal of Infectious Diseases: IJID
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