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Pharmaceutical Development and Technology

Kantrol Kumar Sahu, Ravi Shankar Pandey
The present study was undertaken with an aim to investigate potential of targeting colonic mucosa following oral vaccine delivery to generate prophylactic humoral and mucosal immune response. In present study, response surface methodology (RSM) using the central composite design (CCD) was applied for optimization of process and composition to get uniform, stable reproducible eudragit nanoparticles suitable for targeting to colon. The optimized formulation had the composition of 173 μg HBsAg, 250 mg polymers concentration (4:1 combination of Eudragit S-100 and L-100) and 2% w/v Polyvinyl alcohol (PVA) along with adjuvant Monophosphoryl lipid A (MPLA)...
February 22, 2018: Pharmaceutical Development and Technology
Rania K Eid, Ebtessam A Essa, Gamal M El Maghraby
The fluidity of vesicular membrane affects vesicular transdermal drug delivery. Essential oils can be located in vesicular membrane imparting flexibility and influencing transdermal delivery. Accordingly, the objective was to investigate the effect of incorporation of essential oils in niosomes on felodipine transdermal delivery. Rigid niosomes comprising Span 60 with cholesterol (2:1, w/w) were used with clove, eucalyptus or lemon oils being incorporated in the vesicles at increasing concentrations. The vesicle size and shape was monitored using scanning electron microscopy...
February 14, 2018: Pharmaceutical Development and Technology
Hannlie Hamman, Josias Hamman, Anita Wessels, Jacques Scholtz, Jan Steenekamp
The SeDeM Expert Diagram System (SeDeM EDS) was originally developed to provide information about the suitability of powders to produce direct compressible tablets. Multiple-unit pellet systems (MUPS) are dosage forms consisting of pellets compressed into tablets or loaded into hard gelatine capsules. The aim of this study was to apply the SeDeM EDS to different size pellets (i.e. 0.5, 1.0, 1.5, 2.0 and 2.5 mm) containing different APIs (i.e. doxylamine, ibuprofen or paracetamol) to determine which properties should be corrected to yield MUPS tablet formulations...
February 2, 2018: Pharmaceutical Development and Technology
Carolin Korte, Julian Quodbach
3D-printing via FDM allows the production of individualized solid dosage forms. However, for bringing this benefit to the patient, API-loaded filaments of pharmaceutical grade excipients are necessary as feedstock and have to be produced industrially. As large-scale production of API-loaded filaments has not been described in literature, this study presents a development of 3D-printable filaments, which can continuously be produced via hot-melt extrusion. Further, a combination of testing methods for mechanical resilience of filaments was applied to improve the prediction of their printability...
January 25, 2018: Pharmaceutical Development and Technology
Hassan Zarei, Reza Kazemi Oskuee, Mohammad Yahya Hanafi-Bojd, Leila Gholami, Legha Ansari, Bizhan Malaekeh-Nikouei
Due to large surface area, tunable pore size, easy surface manipulation and low toxicity, mesoporous silica nanoparticles (MSNs) may act as a suitable vector for gene delivery. In order to make MSNs as a suitable gene delivery system, we modified the surface of phosphonated MSNs (PMSN) with polyethyleneimine (PEI) 10 and 25 KDa. Then nanoparticles were loaded with chloroquine (CQ) (a lysosomotropic agent) and complexed with plasmid DNA. The transfection efficiency and cytotoxicity of these nanoparticles was examined using green fluorescent protein plasmid (pGFP) and cytotoxicity assay...
January 23, 2018: Pharmaceutical Development and Technology
Jaleh Varshosaz, Vahab Ziaei, Mohsen Minaiyan, Ali Jahanian, Leila Seyed Tabatabaei
The purpose of the present study was to enhance the bioavailability and anti-osteoporotic effects of raloxifene HCl (RH) by increasing its solubility and inhibition of the p-glycoprotein-pump using surfactant micelles of Igepal CO-890. The micelles were prepared by the direct method and their critical micellar concentration, drug dissolution rate, saturated solubility, drug loading and surface morphology were defined. The cytotoxicity of Igepal CO-890 and its ability to inhibit the p-glycoprotein pump were studied on Caco-2 cells...
January 16, 2018: Pharmaceutical Development and Technology
Huolong Liu, Shaun C Galbraith, Seo-Young Park, Bumjoon Cha, Zhuangrong Huang, Robert Frederick Meyer, Matthew H Flamm, Thomas O'Connor, Sau Lee, Seongkyu Yoon
In this study, a novel three-compartmental population balance model for a continuous twin screw wet granulation process is developed, combining the techniques of population balance modeling and regression process modeling. The developed model links screw configuration, screw speed and blend throughput with granule properties to predict the granule size distribution and volume-average granule diameter. The granulator screw barrel was divided into three compartments along barrel length: wetting compartment, mixing compartment and steady growth compartment...
January 16, 2018: Pharmaceutical Development and Technology
Chengliang Zhang, Yanan Liu, Wei Li, Ping Gao, Dong Xiang, Xiuhua Ren, Dong Liu
A bilayered mucoadhesive buccal film containing a combination of ornidazole (OD) and dexamethasone sodium phosphate (DEX) was prepared using solvent casting to treat oral ulcers. Films were systematically evaluated in vitro to obtain the optimum formulation. The therapeutic effects of these films were investigated in the rabbit oral ulcer model and the in vivo release of OD and DEX in the human oral cavity was also evaluated. The backing layer contained ethyl cellulose and an optimal mucoadhesive layer containing both OD and DEX was produced...
January 15, 2018: Pharmaceutical Development and Technology
Mana Okasaka, Koji Kubota, Emi Yamasaki, Jianzhong Yang, Sadaki Takata
Anionic surfactants are often used for cleaning and pharmaceutical purposes because of their strong surfactancy and foaming property. However, they are rarely ingested orally, the skin is a part of human body most affected by surfactants. Barrier function of the skin is very strong, but the anionic surfactants can serious damage it. Recently, amino acid-based surfactants have attracted attentions as safer options owing to their biocompatibility. Cytotoxicity examinations revealed the amino acid-based surfactants are superior to sulfate-based surfactants...
January 11, 2018: Pharmaceutical Development and Technology
B Siska, E Snejdrova, I Machac, P Dolecek, J Martiska
Rheological behaviour of pharmaceutical semisolid preparations significantly affects manufacturing process, administration, stability, homogeneity of incorporated drug, accuracy of dosing, adhesion in the place of application, drug release, and resulting therapeutic effect of the product. We performed test of consistency by penetrometry, rotational, oscillation and creep tests, and squeeze and tack tests of model samples to introduce methods suitable for characterization and comparison of semisolids in practice...
January 9, 2018: Pharmaceutical Development and Technology
Kaushalendra Chaturvedi, Bhavin Y Gajera, Ting Xu, Harsh Shah, Rutesh H Dave
The objective of the present study was to investigate the influence of processing methods on the physical and mechanical properties of formulations containing Ibuprofen and HPC-SSL. The powder blends, containing Ibuprofen and HPC-SSL in ratio of 9:0.5, were processed using melt granulation (MG) by hot melt extrusion (HME) and wet granulation (WG) by high shear mixer. Formulated granules and powder blends were compressed into round flat faced tablets using Riva Piccola tablet press. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) studies proved that granulation process did not significantly alter the crystallinity of Ibuprofen, however particle density and flow properties were significantly improved...
January 9, 2018: Pharmaceutical Development and Technology
Hamed Nosrati, Reza Adinehvand, Manjili Hamidreza Kheiri, Kobra Rostamizadeh, Hossein Danafar
In this study, we designed a polymersome system for the controlled release of methotrexate (MTX) as an anticancer drug with the objective of improving the loading efficiency of the drug in polymersomes as well as achievement of an efficient control on the release rate of drug from nanocarriers. We synthesized mono methoxy poly (ethylene glycol)-poly (e-caprolactone) (mPEG-PCL) di block copolymers. The structure of the copolymers was characterized by H-NMR, FT-IR and DSC techniques. MTX was encapsulated within nanoparticles through multiple emulsion method...
January 8, 2018: Pharmaceutical Development and Technology
Jinjiang Li, Sneha Rudraraju, Songyan Zheng, Archana Jaiswal
Protein therapeutics are exposed to various surfaces during product development, where their adsorption possibly causes unfolding, denaturation, and aggregation. In this paper, we aim to characterize four types of typical surfaces used in the development of biologics: polycarbonate, polyethersulfone, borosilicate glass, and cellulose. Contact angles of these surfaces were measured using three probing liquids: water, formamide, and diidomethane, from which acid/base (AB) and Lifshitz-van der Waals (LW) interaction components were derived...
January 5, 2018: Pharmaceutical Development and Technology
Shaun C Galbraith, Huolong Liu, Bumjoon Cha, Seo-Young Park, Zhuangrong Huang, Seongkyu Yoon
Continuous manufacturing techniques are increasingly being adopted in the pharmaceutical industry and powder blending is a key operation for solid-dosage tablets. A modeling methodology involving axial and radial tanks-in-series flowsheet models is developed to describe the residence time distribution (RTD) and blend uniformity of a commercial powder blending system. Process data for a six-component formulation processed in a continuous direct compression line (GEA Pharma Systems) is used to test the methodology...
January 5, 2018: Pharmaceutical Development and Technology
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Pharmaceutical Development and Technology
Craig R Bunt
No abstract text is available yet for this article.
April 2018: Pharmaceutical Development and Technology
Raid Alany
No abstract text is available yet for this article.
March 2018: Pharmaceutical Development and Technology
K M Guthrie, L Rohan, R K Rosen, S E Vargas, J G Shaw, D Katz, E M Kojic, A S Ham, D Friend, K W Buckheit, R W Buckheit
Topical prevention of HIV and other STIs is a global health priority. To provide options for users, developers have worked to design safe, effective and acceptable vaginal dissolving film formulations. We aimed to characterize user experiences of vaginal film size, texture and color, and their role in product-elicited sensory perceptions (i.e. perceptibility), acceptability and willingness to use. In the context of a user-centered product evaluation study, we elicited users' 'first impressions' of various vaginal film formulation designs via visual and tactile prototype inspection during a qualitative user evaluation interview...
March 2018: Pharmaceutical Development and Technology
Yanli Li, Bing Xin Xiao, Jie Dong, Yun Liu, Shan Gao, Jie Pang, Zengxian Sun
Combined treatment is more effective than single treatment against most forms of cancer. The synergistic chemo-thermotherapy mediated by nanoparticles has superior advantages of lesser adverse effects as a promising cancer therapy modality. In this study, we report a theranostic carrier system co-encapsulating Doxorubicin (DOX) and Indocyanine green (ICG) into the D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS). Full physicochemical characterization studies of the DOX/ICG-loaded TPGS nanoparticles (TNPs) are performed...
January 2018: Pharmaceutical Development and Technology
Dinghu Zhang, Zhengyun Zou, Wei Ren, Hanqing Qian, Qianfeng Cheng, Liulian Ji, Baorui Liu, Qin Liu
Poor water solubility and side effects hampered the clinical application of gambogic acid (GA) in cancer therapy. Accordingly, GA-loaded polyethylene glycol-poly(ɛ-caprolactone) (PEG-PCL) nanoparticles (GA-NPs) were developed and administered peritumorally to evaluate their antitumor activity. The particle size, polydispersity index, encapsulation efficiency and loading capacity of GA-NPs were 143.78 ± 0.054 nm, 0.179 ± 0.004, 81.3 ± 2.5% and 14.8 ± 0.6%, respectively. In addition, GA-NPs showed excellent stability, good biocompatibility and sustained release profile...
January 2018: Pharmaceutical Development and Technology
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