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Pharmaceutical Development and Technology

Ghada Zidan, Ilva D Rupenthal, Carol Greene, Ali Seyfoddin
Corneal blindness can occur due to improper healing of the corneal tissues after induced injury or abrasion which can be accidental, pathogenic or after corneal surgery. Abnormal regulation of the healing mechanisms can lead to corneal opacity. Reducing inflammation and promoting epithelial wound healing is crucial for scar-free corneal recovery without eyesight complications. Current approaches for corneal wound healing involve amniotic membrane (AM) bandages, bandage contact lenses (BCL) and collagen shields in conjunction with frequent administration of therapeutic eye drops...
September 6, 2017: Pharmaceutical Development and Technology
Ali Ramazani, Mojtaba Keramati, Hojat Malvandi, Hossein Danafar, Hamidreza Kheiri Manjili
PURPOSE: Artemisinin (ART) has anti-inflammatory, antimicrobial, antioxidant, anti-amyloid, and anti-malarial effects, but its application is limited due to its low water solubility and poor oral bioavailability. In this study, the bioavailability, water solubility and anti-plasmodial property of ART were improved by PCL-PEG-PCL triblock copolymers. METHODS: The structure of the copolymers was characterized by (1)HNMR, FT-IR, DSC and GPC techniques. ART was encapsulated within micelles by a single-step nano-precipitation method, leading to the formation of ART-loaded PCL-PEG-PCL micelles...
August 30, 2017: Pharmaceutical Development and Technology
Sachin S Thakur, Jared Solloway, Anneloes Stikkelman, Ali Seyfoddin, Ilva D Rupenthal
This study reports on the impact of cyclodextrin addition on the phase behavior of microemulsion systems. Three distinct oil-in-water microemulsions were formulated and subjected to increasing concentrations of various cyclodextrins. The prepared formulations underwent visual, textural and microscopic characterization followed by evaluation of their in vitro drug release and ex vivo tissue retention behavior. Combining microemulsions with cyclodextrins resulted in either phase separation or transition into a liquid crystalline state depending the concentration and type of cyclodextrin utilized...
August 22, 2017: Pharmaceutical Development and Technology
Dominique Jasmin Lunter
Mesoporous silica particles have recently been used in the preparation of solid oral as well as dermal pharmaceutical formulations. In this work, the use of mesoporous silica of different particle size, pore size and pore volume as carrier for curcumin in hydrogels for dermal use was investigated. Oil absorption capacity of the silica, in vitro release of curcumin from formulations and chemical stability of curcumin during three months storage were evaluated. It was found that the silica particles did not alter in vitro release of curcumin compared to an emulsion...
August 22, 2017: Pharmaceutical Development and Technology
Arunkumar S, Shivakumar H N, S Narasimha Murthy
PURPOSE: The aim of the study was to enhance the transdermal delivery of diclofenac potassium (DP) from hydrogels by constant voltage iontophoresis (CVI). The other objective was to establish the safety and efficacy of CVI in rats. METHODS: Hydrogels of DP were developed using hydroxyethyl cellulose as matrix material and geraniol, l-menthol and thymol as iontophoretic efficiency enhancers (IEE). In vitro permeation of hydrogels under CVI (1.5V) was performed in Franz diffusion cells across porcine skin...
August 17, 2017: Pharmaceutical Development and Technology
Carolina Aloisio, Marcela Longhi
The purpose of this study was to investigate the effect on solubility and dissolution rate of binary complexes of β-(βCD), methyl-(MβCD) and hydroxypropyl-β-cyclodextrin (HPβCD) with diloxanide furoate (DF). The complexation in solution was evaluated by phase solubility studies and (1)H nuclear magnetic resonance (NMR). Enhanced water solubility of DF was obtained with the DF:MβCD system (61-fold). The mode of inclusion was supported by NMR experiments, which indicated that real inclusion complexes were formed between DF and MβCD or HPβCD...
August 16, 2017: Pharmaceutical Development and Technology
Paige Solomon, Jenny Nelson
In this study, we investigated the elemental impurities present in the plastic material of ophthalmic eye drop bottles using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Metallic contaminations, especially localized within the small cavity of the eye, can significantly perturb the ocular metallome. The concern is two-fold: first certain elements, for example heavy metals, can be toxic to humans at even trace levels, and second, these contaminations can have adverse reactions with other medicines or enzymatic processes in the eye...
August 11, 2017: Pharmaceutical Development and Technology
Shengyu Zhang, Liuwan Zhao, Nanqin Qiu, Yanjun Liu, Bohui Xu, Hongyan Zhu
Hypoxia, an outstanding characteristic of various solid tumors, has been considered a critical factor of aggressive tumor phenotypes, poor clinical prognosis, and increased expression of the multi drug-resistant gene. Therefore, it is critical to develop a drug delivery system to enhance the delivery effect of the antitumor drug in the hypoxic tumor. We constructed two types of tumor-targeting micelles based on chitosan, and evaluated their properties in targeting hypoxic tumors. Chitosan-based micelles consisted of a hydrophobic group octyl group, a hydrophilic polyethylene glycol, tumor-targeting ligands glucosamine or folic acid, and a transmembrane peptide 9-D-arginine...
August 7, 2017: Pharmaceutical Development and Technology
Michael Chetcuti, Anthony Serracino-Inglott, Gavril Flores, John J Borg
The aim of this study was to identify pharmaceutical issues encountered during regulatory review in European Procedures. A database of issues from Day 70 assessment reports of 150 EU procedures was compiled; most procedures were for generics (108). Frequencies of common deficiencies have been calculated and summarised for use of all stakeholders. Out of the 150 procedures reviewed, covering 309 products, a total of 4796 concerns were identified. Of these concerns, 167 were Potential Serious Risks to Public Health, 67 were raised on drug substance and 100 on the drug product...
August 7, 2017: Pharmaceutical Development and Technology
Amr ElShaer, Ali Al-Khattawi, Afzal R Mohammed, Monika Warzecha, Dimitrios A Lamprou, Hany Hassanin
The fast development in materials science has resulted in the emergence of new pharmaceutical materials with superior physical and mechanical properties. Low-substituted hydroxypropyl cellulose is an ether derivative of cellulose and is praised for its multi-functionality as a binder, disintegrant, film coating agent and as a suitable material for medical dressings. Nevertheless, very little is known about the compaction behaviour of this polymer. The aim of the current study was to evaluate the compaction and disintegration behaviour of four grades of L-HPC namely; LH32, LH21, LH11 and LHB1...
August 4, 2017: Pharmaceutical Development and Technology
Mouhamad Khoder, Hamdy Abdelkader, Amr ElShaer, Ayman Karam, Mohammad Najlah, Raid G Alany
In this study, solid dispersions of prednisolone (PRD) and bovine serum albumin (BSA) were prepared by spray drying and freeze drying methods using a PRD:BSA solution (20:1 Molar Ratio (MR)). PRD-BSA dispersed mixtures were characterised by scanning electron microscopy (SEM), and powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC). PRD-BSA physical and dispersed mixtures showed significantly higher solubility in water than that of unprocessed drug. Enhancement factor of six was obtained in both physical mixture and solid dispersion solubility studies...
August 3, 2017: Pharmaceutical Development and Technology
Krzysztof Siczek, Jakub Fichna, Hubert Zatorski, Bożena Karolewicz, Leszek Klimek, Artur Owczarek
CONTEXT: Recent findings indicating the anti-inflammatory action of silver preparations through modulation of the gut microbiota and apoptosis of inflammatory cells predestine silver use in inflammatory bowel disease (IBD). OBJECTIVE: The aim of our study was to validate the possibility of effective silver release from silver-coated glass beads for anti-inflammatory local application in the lower sections of the gastrointestinal (GI) tract. MATERIALS AND METHODS: Silver-coated glass beads were prepared using magnetron method...
August 3, 2017: Pharmaceutical Development and Technology
Pascale Gauthier, Jean-Michel Cardot, Erick Beyssac, Jean-Marc Aiache
Different previous works have shown that various kinds of spheres can be manufactured by rotor granulation in a 'single-pot process' using a lipid base: hydrogenated castor oil. This single-pot technology is based on wet granulation where all components are placed in the powder form in the rotor bowl; then, they are continuously suspended in a fluidized air, with a tangentially sprayed liquid solution. This process allows the granulation and manufacturing of sphere during the same time. Previous experiments have studied the influence of the formulation and the manufacturing process parameters on spheres in terms of feasibility and dissolution properties...
July 26, 2017: Pharmaceutical Development and Technology
Tahir Emre Yalcin, Sibel Ilbasmis-Tamer, Burçin Ibisoglu, Aysun Özdemir, Mustafa Ark, Sevgi Takka
The aim of this study is to formulate and compare the physicochemical properties of negatively-charged liposomes and poly-lactide-co-glycolide (PLGA) nanoparticles loaded with gemcitabine hydrochloride. The influence of the formulation variables on the liposome and nanoparticle properties on particle size, zeta potential, encapsulation efficiency and drug release were evaluated. Although the PEGylated nanoparticles and PEGylated liposomes were of the same size (∼200 nm), the encapsulation efficiency was 1...
July 20, 2017: Pharmaceutical Development and Technology
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No abstract text is available yet for this article.
July 17, 2017: Pharmaceutical Development and Technology
Shaza El-Nemr, Basma Y Al-Najjar, Huner K Omer, Abdelbary M A Elhissi, Mohamed A Alhnan
Cremophor EL (CrEL) is commonly used to solubilize paclitaxel (Ptx); a widely established anticancer agent used against many types of cancer. Using laser-based microplate nephelometry, in this work we assessed the precipitation kinetics of Ptx in CrEL-containing formulations upon dilutions with different infusion media or upon introduction into rat plasma. The precipitation profile of Ptx was assessed for a Taxol-like formulation and compared with an preparation with reduced CrEL content. These two formulations were diluted at various ratios in compatible infusion media and with or without rat plasma...
July 11, 2017: Pharmaceutical Development and Technology
Gholamreza Aryanpour, Masoud Farzaneh
Die compaction is widely used in the compaction of pharmaceutical powders (tableting). It is well known that the powder densification is a result of particle rearrangement and particle deformation. The former is considered to be the governing mechanism of densification in an initial stage of compaction and the latter is regarded as the governing mechanism in the compaction at the higher pressure range. As a more realistic assumption, one can consider that a simultaneous performance of both the rearrangement and deformation mechanisms takes place from the beginning of compaction...
July 6, 2017: Pharmaceutical Development and Technology
Ugne Cizauskaite, Mindaugas Marksa, Jurga Bernatoniene
For the last couple of decades multiple emulsions were prepared either by the re-emulsification of primary emulsion or they were produced by an emulsion inversion and their technological peculiarities were widely investigated. The aim of our study was to investigate and determine the optimal technological parameters of innovative multiple emulsion, prepared directly - by addition of ethanolic rosemary extract in the presence of polymeric emulsifier - and evaluate its stability by experimental surface response design approach...
July 4, 2017: Pharmaceutical Development and Technology
Sıla Gülbağ, Duygu Yılmaz Usta, Hazal E Gültekin, Ayşe N Oktay, Özden Demirtaş, Alptuğ Karaküçük, Nevin Çelebi
Nowadays pharmaceutical industries and regulatory authorities suggest new approaches such as Quality by Design principles to reduce experiments of formulation studies, improve product quality, save cost and time. SeDeM Expert System is a predictive approach for the preformulation studies and it provides information about suitability of API for direct compression by evaluating 12 parameters. The system also allows selecting appropriate excipients by determining same parameters to improve compressibility of API...
June 28, 2017: Pharmaceutical Development and Technology
Elham Jafarifar, Marziyeh Hajialyani, Mona Akbari, Masoud Rahimi, Yalda Shokoohinia, Ali Fattahi
The aim of the present study is to prepare risperidone-loaded poly lactic-co-glycolic acid (PLGA) microspheres within microfluidic system and to achieve a formulation with uniform size and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optimizing study was carried out at different processing parameters (e.g. PLGA and surfactant concentration and flow rates ratio of outer to inner phase). The computational fluid dynamic (CFD) modeling was performed, and loading and release study were carried out...
September 2017: Pharmaceutical Development and Technology
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