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Vascular Medicine

Natalie S Evans, Elizabeth V Ratchford
No abstract text is available yet for this article.
October 12, 2016: Vascular Medicine
Sherry M Bumpus, Christa Kuck, Steven T Heidt, Minnie Bluhm
Fibromuscular dysplasia (FMD) is a vascular disorder about which little has been known until recently. Patients with FMD may suffer from hypertension, aneurysms, or strokes, as well as symptoms associated with local artery damage. As a result of advances in vascular medicine and growing outcomes registries, we now have a better understanding of the FMD disease process and epidemiology. Nevertheless, the consequences of FMD on patients' day-to-day experiences and mental health status are not well understood...
October 6, 2016: Vascular Medicine
Héctor A Carmona-Ruiz, Juan Carlos Heredia-Gutiérrez, Oscar Orihuela-Rodríguez
No abstract text is available yet for this article.
October 5, 2016: Vascular Medicine
Akhilesh K Sista, Larry E Miller, Susan R Kahn, Jeffrey A Kline
Long-term right ventricular (RV) function, functional capacity, exercise capacity, and quality of life following pulmonary embolism (PE), and the impact of thrombolysis, are unclear. A systematic review of studies that evaluated these outcomes with ⩾ 3-month mean follow-up after PE diagnosis was performed. For each outcome, random effects meta-analyses were performed. Twenty-six studies (3671 patients) with 18-month median follow-up were included. The pooled prevalence of RV dysfunction was 18.1%. Patients treated with thrombolysis had a lower, but not statistically significant, risk of RV dysfunction versus those treated with anticoagulation (odds ratio: 0...
October 5, 2016: Vascular Medicine
Melissa G Farb, Shakun Karki, Song-Young Park, Samantha M Saggese, Brian Carmine, Donald T Hess, Caroline Apovian, Jessica L Fetterman, Rosa Bretón-Romero, Naomi M Hamburg, José J Fuster, María A Zuriaga, Kenneth Walsh, Noyan Gokce
Obesity is associated with the development of vascular insulin resistance; however, pathophysiological mechanisms are poorly understood. We sought to investigate the role of WNT5A-JNK in the regulation of insulin-mediated vasodilator responses in human adipose tissue arterioles prone to endothelial dysfunction. In 43 severely obese (BMI 44±11 kg/m(2)) and five metabolically normal non-obese (BMI 26±2 kg/m(2)) subjects, we isolated arterioles from subcutaneous and visceral fat during planned surgeries. Using videomicroscopy, we examined insulin-mediated, endothelium-dependent vasodilator responses and characterized adipose tissue gene and protein expression using real-time polymerase chain reaction and Western blot analyses...
September 28, 2016: Vascular Medicine
Yasuhiro Suyama, Mitsumasa Kishimoto, Shinji Togashi, Yasushi Terada, Masato Okada
No abstract text is available yet for this article.
September 28, 2016: Vascular Medicine
Stephanie M Moore, Adam J Berrones, Jody L Clasey, Mark G Abel, Bradley S Fleenor
Higher body mass index (BMI) is associated with greater cardiovascular disease (CVD) risk, in part due to aortic stiffening assessed by carotid-femoral pulse wave velocity (cfPWV). Importantly, greater cardiorespiratory fitness (CRF; VO2peak) decreases CVD risk, and is associated with reductions in aortic stiffness. We tested the hypothesis that young adult overweight (OW, n=17) compared with healthy-weight (HW, n=17) men will have greater resting aortic stiffness, reduced CRF and an impaired post-exercise hemodynamic response...
September 28, 2016: Vascular Medicine
John D Kakisis, Konstantinos G Moulakakis, George S Sfyroeras, George Geroulakos
No abstract text is available yet for this article.
September 15, 2016: Vascular Medicine
Nima Toosizadeh, Hannah Stocker, Rebecca Thiede, Jane Mohler, Joseph L Mills, Bijan Najafi
Although poor walking is the most common symptom of peripheral artery disease (PAD), reported results are inconsistent when comparing gait parameters between PAD patients and healthy controls. This inconsistency may be due to frailty, which is highly prevalent among PAD patients. To address this hypothesis, 41 participants, 17 PAD (74±8 years) and 24 aged-matched controls (76±7 years), were recruited. Gait was objectively assessed using validated wearable sensors. Analysis of covariate (ANCOVA) tests were used to compare gait parameters between PAD and non-PAD groups, considering age, gender, and body mass index as covariates, while stratified based on frailty status...
September 15, 2016: Vascular Medicine
Abbi D Lane-Cordova, Jordan R Witmer, Kaitlyn Dubishar, Lyndsey E DuBose, Catherine A Chenard, Kyle J Siefers, Janie E Myers, Lauren J Points, Gary L Pierce
A diet high in trans-fatty acids (TFAs) is associated with a higher risk of cardiovascular disease (CVD) than a diet high in saturated fatty acids (SFAs), but the mechanisms remain unclear. We hypothesized that a beverage high in TFAs would cause a larger reduction in postprandial endothelial function and an increase in arterial stiffness, in part from greater reductions in insulin sensitivity, compared with a beverage high in SFAs. Eleven healthy adults (aged 47±5 years) ingested a warm test beverage (520 kcal, 56 g total fat, 5 g carbohydrate, 1 g protein) high in either TFAs or SFAs in a randomized cross-over study...
August 23, 2016: Vascular Medicine
Anne Albers
No abstract text is available yet for this article.
August 2016: Vascular Medicine
Mary McGrae McDermott
No abstract text is available yet for this article.
August 2016: Vascular Medicine
Yonathan Litwok, Michael Weinreich, Joe F Lau
No abstract text is available yet for this article.
August 2016: Vascular Medicine
Suresh Vedantham, Susan R Kahn, Samuel Z Goldhaber, Anthony J Comerota, Sameer Parpia, Sreelatha Meleth, Diane Earp, Rick Williams, Akhilesh K Sista, William Marston, Suman Rathbun, Elizabeth A Magnuson, Mahmood K Razavi, Michael R Jaff, Clive Kearon
Patients with advanced post-thrombotic syndrome (PTS) and chronic iliac vein obstruction suffer major physical limitations and impairment of health-related quality of life. Currently there is a lack of evidence-based treatment options for these patients. Early studies suggest that imaging-guided, catheter-based endovascular therapy can eliminate iliac vein obstruction and saphenous venous valvular reflux, resulting in reduced PTS severity; however, these observations have not been rigorously validated. A multidisciplinary expert panel meeting was convened to plan a multicenter randomized controlled clinical trial to evaluate endovascular therapy for the treatment of advanced PTS...
August 2016: Vascular Medicine
Viktoria Tuveson, Hedvig E Löfdahl, Rebecka Hultgren
Patients with abdominal aortic aneurysms (AAA) are more prone to develop popliteal artery aneurysms (PAA), but the prevalence is not well known. Our aim was to investigate the prevalence of PAA in patients with AAA, and to determine whether a certain risk factor profile is more commonly found in patients with concurrent aneurysms. All AAA patients (ICD code I71.3, I71.4) attending the outpatient clinic at the Karolinska University Hospital between 2011 and 2013 were included in the study cohort (n=465); 48% (225) had been subjected to an ultrasound or computed tomography scan of their popliteal arteries...
August 2016: Vascular Medicine
Peta Ellen Tehan, Derek Santos, Vivienne Helaine Chuter
The toe-brachial index (TBI) is used as an adjunct to the ankle-brachial index (ABI) for non-invasive lower limb vascular screening. With increasing evidence suggesting limitations of the ABI for diagnosis of vascular complications, particularly in specific populations including diabetes cohorts, the TBI is being used more widely. The aim of this review was to determine the sensitivity and specificity of the TBI for detecting peripheral artery disease (PAD) in populations at risk of this disease. A database search was conducted to identify current work relating to the sensitivity and specificity of toe-brachial indices up to July 2015...
August 2016: Vascular Medicine
Gregory Piazza, Venkatesh Mani, Samuel Z Goldhaber, Michael A Grosso, Michele Mercuri, Hans J Lanz, Steven Schussler, Ching Hsu, Amy Chinigo, Bruce Ritchie, Venkatesh Nadar, Kevin Cannon, John Pullman, Mauricio Concha, Marlin Schul, Zahi A Fayad
The feasibility of magnetic resonance venography (MRV) for measuring change in thrombus volume with a novel anticoagulation regimen versus standard anticoagulation in patients with symptomatic deep vein thrombosis (DVT) has not been assessed. Our aim was to study the feasibility of MRV to measure change in thrombus volume in patients with acute symptomatic objectively confirmed proximal DVT in an open-label multicenter trial (edoxaban Thrombus Reduction Imaging Study, eTRIS). We randomized patients in a 2:1 allocation ratio to edoxaban 90 mg/day for 10 days followed by 60 mg/day versus parenteral anticoagulation bridging to warfarin for 3 months...
August 2016: Vascular Medicine
Yongzhe Hong, Meghan Sebastianski, Mark Makowsky, Ross Tsuyuki, M Sean McMurtry
We sought to evaluate whether case ascertainment using administrative health data would be a feasible way to identify peripheral artery disease (PAD) patients from the community. Subjects' ankle-brachial index (ABI) scores from two previous prospective observational studies were linked with International Classification of Diseases (ICD) and Canadian Classification of Interventions (CCI) codes from three administrative databases from April 2002 to March 2012, including the Alberta Inpatient Hospital Database (ICD-10-CA/CCI), Ambulatory Care Database (ICD-10-CA/CCI), and the Practitioner Payments Database (ICD-9-CM)...
August 2016: Vascular Medicine
Melissa D Chittle, Rahmi Oklu, Richard M Pino, Ping He, Robert M Sheridan, Joanne Martino, Joshua A Hirsch
This study was undertaken to determine the impact of shared decision-making when selecting a sedation option, from no sedation (local anesthetic), minimal sedation (anxiolysis with a benzodiazepine) or moderate sedation (benzodiazepine and opiate), for venous access device placement (port-a-cath and tunneled catheters) on patient choice, satisfaction and recovery time. This is an IRB-approved, HIPPA-compliant, retrospective study of 198 patients (18-85 years old, 60% female) presenting to an ambulatory vascular interventional radiology department for venous access device placement between 22 October 2014 and 7 October 2015...
August 2016: Vascular Medicine
Daniel M Shivapour, Phillip Erwin, Esther Sh Kim
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disease of medium sized arteries that has been described in multiple anatomic territories with a wide variety of manifestations (e.g. beading, stenosis, occlusion, aneurysm, or dissection). While the first case of FMD is thought to have been described over 75 years ago, the causes, natural history, and epidemiology of FMD in the general population remain incompletely understood. This article reviews important historical and contemporary contributions to the FMD literature that inform our current understanding of the prevalence and epidemiology of this important disorder...
August 2016: Vascular Medicine
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