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Vascular Medicine

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https://www.readbyqxmd.com/read/28145161/repetitive-ischemia-increases-myocardial-dimethylarginine-dimethylaminohydrolase-1-expression
#1
Ping Zhang, John T Fassett, Guangshuo Zhu, Jingxin Li, Xinli Hu, Xin Xu, Yingjie Chen, Robert J Bache
Pharmacologic inhibition of nitric oxide production inhibits growth of coronary collateral vessels. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is the major enzyme that degrades asymmetric dimethylarginine (ADMA), a potent inhibitor of nitric oxide synthase. Here we examined regulation of the ADMA-DDAH1 pathway in a canine model of recurrent myocardial ischemia during the time when coronary collateral growth is known to occur. Under basal conditions, DDAH1 expression was non-uniform across the left ventricular (LV) wall, with expression strongest in the subepicardium...
January 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28145158/impact-of-dpp-4-inhibition-on-acute-and-chronic-endothelial-function-in-humans-with-type-2-diabetes-on-background-metformin-therapy
#2
Michael E Widlansky, Venkata K Puppala, Tisha M Suboc, Mobin Malik, Amberly Branum, Kara Signorelli, Jingli Wang, Rong Ying, Michael J Tanner, Sudhi Tyagi
Cell culture and animal work indicate that dipeptidyl peptidase-4 (DPP-4) inhibition may exert cardiovascular benefits through favorable effects on the vascular endothelium. Prior human studies evaluating DPP-4 inhibition have shown conflicting results that may in part be related to heterogeneity of background anti-diabetes therapies. No study has evaluated the acute response of the vasculature to DPP-4 inhibition in humans. We recruited 38 patients with type 2 diabetes on stable background metformin therapy for a randomized, double-blind, placebo-controlled crossover trial of DPP-4 inhibition with sitagliptin (100 mg/day)...
January 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28145152/same-tt2r2-predicts-quality-of-anticoagulation-in-patients-with-acute-venous-thromboembolism-the-maqi-2-experience
#3
Akash Kataruka, Xiaowen Kong, Brian Haymart, Eva Kline-Rogers, Steve Almany, Jay Kozlowski, Gregory D Krol, Scott Kaatz, Michael W McNamara, James B Froehlich, Geoffrey D Barnes
A high SAMe-TT2R2 score predicted poor warfarin control and adverse events among atrial fibrillation patients. However, the SAMe-TT2R2 score has not been well validated in venous thromboembolism (VTE) patients. A cohort of 1943 warfarin-treated patients with acute VTE was analyzed to correlate the SAMe-TT2R2 score with time in therapeutic range (TTR) and clinical adverse events. A TTR <60% was more frequent among patients with a high (>2) versus low (0-1) SAMe-TT2R2 score (63.4% vs 52.3%, p<0.0001)...
January 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28132595/the-temporal-trend-of-vascular-function-in-women-with-gestational-diabetes
#4
Priyanka Garg, Smriti Badhwar, Ashok Kumar Jaryal, Garima Kachhawa, Kishore Kumar Deepak, Alka Kriplani
The objective of the study was to assess the temporal changes in vascular function during pregnancy in healthy women and in those with gestational diabetes mellitus (GDM). Assessment of vascular function was done at three time points, 11-13(+6) weeks(+days), 20-22(+6) weeks(+days) and 30-32(+6) weeks(+days), by flow-mediated dilatation (FMD), augmentation index (AIx) and carotid-radial pulse wave velocity (crPWV) in women ( n=100) with singleton pregnancies. Out of the 100 women, 20 developed GDM, who were compared with 20 healthy, age-matched pregnant women in a nested case-control design...
January 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28095749/obese-adolescents-with-polycystic-ovarian-syndrome-have-elevated-cardiovascular-disease-risk-markers
#5
Sonali S Patel, Uyen Truong, Martina King, Annie Ferland, Kerrie L Moreau, Jennifer Dorosz, John E Hokanson, Hong Wang, Gregory L Kinney, David M Maahs, Robert H Eckel, Kristen J Nadeau, Melanie Cree-Green
Women with polycystic ovarian syndrome (PCOS) have evidence of subclinical cardiovascular disease (CVD). However, insulin resistance, an important factor in the development of CVD in adults, is common in adolescents with PCOS, yet data in adolescents are limited. Therefore, we sought to measure insulin resistance and CVD markers in obese youth with and without PCOS. Thirty-six PCOS and 17 non-PCOS adolescent girls who were obese, sedentary, and non-hypertensive were recruited from clinics located within the Children's Hospital Colorado...
January 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28215109/lipoprotein-associated-phospholipase-a2-and-risk-of-incident-peripheral-arterial-disease-in-a-multi-ethnic-cohort-the-multi-ethnic-study-of-atherosclerosis
#6
Parveen K Garg, Neal W Jorgensen, Robyn L McClelland, Nancy S Jenny, Michael H Criqui, Matthew A Allison, Philip Greenland, Robert S Rosenson, David S Siscovick, Mary Cushman
Prospective studies supporting a relationship between elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) and incident peripheral arterial disease (PAD) are limited. We evaluated the association of Lp-PLA2 with incident PAD in a multi-ethnic cohort without clinical cardiovascular disease. A total of 4622 participants with measurement of Lp-PLA2 mass and Lp-PLA2 activity and an ankle-brachial index (ABI) between 0.9 and 1.4 were followed for the development of PAD (median follow-up = 9.3 years), defined as an ABI ⩽0...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28215108/antithrombotic-therapy-in-aortic-diseases-a-narrative-review
#7
Francois Caron, Sonia S Anand
Aortic diseases are a heterogeneous group of disorders, including atherothrombotic conditions like aortic atheroma, cholesterol embolization syndrome, aortic mural thrombus, thrombus within an aneurysm, and large vessel vasculitis. In this review, we provide a summary of the current evidence regarding atherothrombotic diseases of the aorta, focusing on therapeutic avenues. In patients with previous stroke, aortic arch atheroma is recognized as a strong predictor of recurrent atheroembolism, and antiplatelet therapy alone is still associated with a high (11...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28215107/letter-to-the-vascular-medicine-readership
#8
Heather L Gornik
No abstract text is available yet for this article.
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28215106/svm-28th-annual-scientific-sessions-and-abvm-recertification
#9
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28215105/advanced-vascular-imaging
#10
Michael Weinreich, Yonathan Litwok, Leonora W Mui, Joe F Lau
No abstract text is available yet for this article.
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27940922/peripheral-vascular-intervention-is-better-than-tibial-bypass-for-critical-limb-ischemia
#11
Bruce H Gray
No abstract text is available yet for this article.
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27928034/below-knee-endovascular-interventions-have-better-outcomes-compared-to-open-bypass-for-patients-with-critical-limb-ischemia
#12
Caitlin W Hicks, Alireza Najafian, Alik Farber, Matthew T Menard, Mahmoud B Malas, James H Black, Christopher J Abularrage
Both open surgery and endovascular peripheral interventions have been shown to effectively improve outcomes in patients with peripheral artery disease, but minimal data exist comparing outcomes performed at and below the knee. The purpose of this study was to compare outcomes following infrageniculate lower extremity open bypass (LEB) versus peripheral vascular intervention (PVI) in patients with critical limb ischemia. Using data from the 2008-2014 Vascular Quality Initiative, 1-year primary patency, major amputation, and mortality were compared among all patients undergoing LEB versus PVI at or below the knee for rest pain or tissue loss...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27913777/risk-factors-for-major-bleeding-in-the-seattle-ii-trial
#13
Immad Sadiq, Samuel Z Goldhaber, Ping-Yu Liu, Gregory Piazza
Ultrasound-facilitated, catheter-directed, low-dose fibrinolysis minimizes the risk of intracranial bleeding compared with systemic full-dose fibrinolytic therapy for pulmonary embolism (PE). However, major bleeding is nevertheless a potential complication. We analyzed the 150-patient SEATTLE II trial of submassive and massive PE patients to describe those who suffered major bleeding events following ultrasound-facilitated, catheter-directed, low-dose fibrinolysis and to identify risk factors for bleeding. Major bleeding was defined as GUSTO severe/life-threatening or moderate bleeds within 72 hours of initiation of the procedure...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27903955/effect-of-diabetes-mellitus-on-walking-distance-parameters-after-supervised-exercise-therapy-for-intermittent-claudication-a-systematic-review
#14
David Hageman, Lindy Nm Gommans, Marc Rm Scheltinga, Joep Aw Teijink
Some believe that certain patients with intermittent claudication may be unsuitable for supervised exercise therapy (SET), based on the presence of comorbidities and the possibly increased risks. We conducted a systematic review (MEDLINE, EMBASE and CENTRAL) to summarize evidence on the potential influence of diabetes mellitus (DM) on the response to SET. Randomized and nonrandomized studies that investigated the effect of DM on walking distance after SET in patients with IC were included. Considered outcome measures were maximal, pain-free and functional walking distance (MWD, PFWD and FWD)...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27821586/ruptured-abdominal-aortic-aneurysm
#15
Umberto G Rossi, Pierluca Torcia, Maurizio Cariati
No abstract text is available yet for this article.
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27811237/low-utility-of-lower-extremity-ultrasound-prior-to-application-of-sequential-compression-device-in-critically-ill-adults
#16
Eliane Younes, Fady Haddad, Hani Tamim, Ali Taher, Imad BouAkl, Hassan A Chami
No abstract text is available yet for this article.
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27811236/a-multidisciplinary-quality-improvement-program-increases-the-inferior-vena-cava-filter-retrieval-rate
#17
John P Winters, Christopher S Morris, Chris E Holmes, Patricia Lewis, Anant D Bhave, Kenneth E Najarian, Joseph T Shields, William Charash, Mary Cushman
Published reports indicate low retrieval rates for retrievable inferior vena cava (IVC) filters. We performed a historic-controlled study of a 5-year intervention (March 2007 to February 2012) to improve IVC filter retrieval rates at a university medical center serving a rural area. All adults with a retrievable filter placed were included, except those with a life expectancy <6 months. The intervention included initial verbal counseling and printed educational materials, correspondence after discharge, and a hematology consultation...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27799423/novel-association-between-bone-mineral-density-scores-and-the-prevalence-of-peripheral-artery-disease-in-both-sexes
#18
Melissa J Baldwin, Aleksandra Policha, Thomas Maldonado, Jade S Hiramoto, Stephen Honig, Michael S Conte, Jeffrey Berger, Caron B Rockman
The purpose of the current study was to investigate the association between bone mineral density (BMD) scores and the prevalence of peripheral artery disease (PAD) in a large cohort of subjects who underwent arterial Doppler assessments and calcaneal bone densitometry. The study was performed using data obtained from Life Line Screening Inc. Subjects were self-selected and paid for screening tests. The prevalence of PAD was significantly higher in men with osteopenia (4.5%) and osteoporosis (10.9%) compared to men with normal BMD (3...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27707980/persistent-right-ventricular-dysfunction-functional-capacity-limitation-exercise-intolerance-and-quality-of-life-impairment-following-pulmonary-embolism-systematic-review-with-meta-analysis
#19
Akhilesh K Sista, Larry E Miller, Susan R Kahn, Jeffrey A Kline
Long-term right ventricular (RV) function, functional capacity, exercise capacity, and quality of life following pulmonary embolism (PE), and the impact of thrombolysis, are unclear. A systematic review of studies that evaluated these outcomes with ⩾ 3-month mean follow-up after PE diagnosis was performed. For each outcome, random effects meta-analyses were performed. Twenty-six studies (3671 patients) with 18-month median follow-up were included. The pooled prevalence of RV dysfunction was 18.1%. Patients treated with thrombolysis had a lower, but not statistically significant, risk of RV dysfunction versus those treated with anticoagulation (odds ratio: 0...
February 2017: Vascular Medicine
https://www.readbyqxmd.com/read/27681488/cold-associated-painful-purple-digits-due-to-type-i-cryoglobulinemia
#20
Yasuhiro Suyama, Mitsumasa Kishimoto, Shinji Togashi, Yasushi Terada, Masato Okada
No abstract text is available yet for this article.
February 2017: Vascular Medicine
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