Hiba Zaaroura, Benoit Cyrenne, Gino R Somers, Karen Wy Wong, Kristen M Davidge, Evan J Propst, Abhaya V Kulkarni, Winnie Lo, Anita Villani, Irene Lara-Corrales, Rebecca Levy
Pigmented epithelioid melanocytomas (PEM) are intermediate-grade melanocytic lesions with frequent lymph node involvement and rare metastases that tend to follow an indolent course with a favorable outcome. We report two unique cases of congenital PEM with PRKCA fusion transcripts: a multifocal PEM with an aggressive incompletely resectable scalp tumor and a solitary palmar PEM with newly reported ITGB5-PRKCA fusion. Through these case reports and a summary of previously reported cases, we outline the spectrum of disease of PEM and highlight the key clinical and histopathologic features associated with PEM with PRKCA fusion transcripts...
October 15, 2023: Dermatology Online Journal