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Kidney & Blood Pressure Research

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https://www.readbyqxmd.com/read/28531898/plasma-et-1-concentrations-are-elevated-in-patients-with-hypertension-meta-analysis-of-clinical-studies
#1
Mei Xu, Yong-Ping Lu, Ahmed Abdallah Hasan, Berthold Hocher
BACKGROUND/AIMS: A recent study revealed that global overexpression of ET-1 causes a slight reduction in systemic blood pressure. Moreover, heterozygous ET-1 knockout mice are hypertensive. The role of ET-1 in human hypertension was so far not addressed by a strict meta-analysis of published human clinical studies. METHODS: We included studies published between January 1, 1990 and February 28, 2017. We included case control studies analyzing untreated essential hypertension or hypertensive patients where antihypertensive medication was discontinued for at least two weeks...
May 26, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531904/routine-monitoring-of-sodium-and-phosphorus-removal-in-peritoneal-dialysis-pd-patients-treated-with-continuous-ambulatory-pd-capd-automated-pd-apd-or-combined-capd-apd
#2
Veronika Moor, Robert Wagner, Michael Sayer, Marlies Petsch, Sandra Rueb, Hans-Ulrich Häring, Nils Heyne, Ferruh Artunc
BACKGROUND: Adequate removal of sodium (Na) and phosphorus (P) is of paramount importance for patients with dialysis-dependent kidney disease can easily quantified in peritoneal dialysis (PD) patients. Some studies suggest that automated PD (APD) results in lower Na and P removal. METHODS: In this study we retrospectively analysed our data on Na and P removal in PD patients after implementation of a routine monitoring in 2011. Patients were stratified in those treated with continuous ambulatory PD (CAPD, n=24), automated PD (APD, n=23) and APD with one bag change (CAPD+APD, n=10)...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531900/factors-associated-with-blood-pressure-variability-based-on-ambulatory-blood-pressure-monitoring-in-subjects-with-hypertension-in-china
#3
Wei Li, YanXia Yu, Dehong Liang, En-Zhi Jia
BACKGROUND/AIMS: We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. METHODS: A total of 318 consecutive adult subjects aged 29-94 years with suspected or known hypertension were enrolled in this study. Blood pressure variability measurements were based on ambulatory blood pressure monitoring...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531895/arterial-stiffness-is-an-independent-risk-factor-for-anemia-after-percutaneous-native-kidney-biopsy
#4
Keiko Tanaka, Masashi Kitagawa, Akifumi Onishi, Toshio Yamanari, Ayu Ogawa-Akiyama, Koki Mise, Tatsuyuki Inoue, Hiroshi Morinaga, Haruhito A Uchida, Hitoshi Sugiyama, Jun Wada
BACKGROUND/AIMS: Bleeding is the most common complication after renal biopsy. Although numerous predictors of bleeding have been reported, it remains unclear whether arterial stiffness affects bleeding complications. METHOD: We performed an observational study of the renal biopsies performed in our division over an approximately 6-year period (May 2010 to May 2016). The clinical and laboratory factors were analyzed to reveal the risk factors associated with bleeding, with a focus on anemia (defined as a ≥10% decrease in hemoglobin [Hb] after biopsy)...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531894/evaluation-of-absolute-serum-creatinine-changes-in-staging-of-cirrhosis-induced-acute-renal-injury-and-its-association-with-long-term-outcomes
#5
Fangfang Zhou, Qun Luo, Lina Han, Huadong Yan, Wenhong Zhou, Zemin Wang, Yumei Li
BACKGROUND/AIMS: To assess the prognostic accuracy of absolute serum creatinine (sCr) changes ('Delta-sCr') on the long-term outcomes in cirrhotic patients, and evaluate the performance of the 'Delta-sCr' approach to stage acute kidney injury (AKI), compared with the Kidney Disease Improving Global Outcomes (KDIGO) criteria. METHODS: We conducted a retrospective analysis of 333 hospitalized patients. We classified AKI stages using two methods: 1) KDIGO AKI criteria; 2) 'Delta-sCr' system, defined by the difference between the baseline and the peak sCr value during the hospitalization...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531889/gender-specific-differences-in-peritoneal-dialysis
#6
Daniel Kitterer, Stephan Segerer, Niko Braun, M Dominik Alscher, Joerg Latus
BACKGROUND/AIMS: Gender-specific differences between patients on renal replacement therapy have so far rarely been investigated. In the present study we aimed to describe gender-specific differences in a large cohort of peritoneal dialysis (PD) patients. METHODS: Clinical information for all patients who started PD at our center has been collected since the start of the PD-program in 1979. We used Cox regression to examine associations between technique failure and gender...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28531884/pre-interventional-kynurenine-predicts-medium-term-outcome-after-contrast-media-exposure-due-to-coronary-angiography
#7
Christoph Reichetzeder, Fabian Heunisch, Gina von Einem, Oleg Tsuprykov, Karl-Heinz Kellner, Thomas Dschietzig, Axel Kretschmer, Berthold Hocher
BACKGROUND/AIMS: Contrast induced acute kidney injury (CI-AKI) remains a serious complication of contrast media enhanced procedures like coronary angiography. There is still a lack of established biomarkers that help to identify patients at high risk for short and long-term complications. The aim of the current study was to evaluate plasma kynurenine as a predictive biomarker for CI-AKI and long-term complications, measured by the combined endpoint "major adverse kidney events" (MAKE) up to 120 days after CM application...
May 25, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28514782/a-systematic-review-and-meta-analysis-of-influenza-a-virus-infection-during-pregnancy-associated-with-an-increased-risk-for-stillbirth-and-low-birth-weight
#8
Jing He, Zhi-Wei Liu, Yong-Ping Lu, Tao-Yuan Li, Xu-Jing Liang, Petra C Arck, Si-Min Huang, Berthold Hocher, You-Peng Chen
BACKGROUND/AIMS: Impaired pregnancy outcomes, such as low birth weight are associated with increased disease risk in later life, however little is known about the impact of common infectious diseases during pregnancy on birth weight. The study had two aims: a) to investigate risk factors of influenza virus infection during pregnancy, and b) to analyze the impact of influenza virus infection on pregnancy outcome, especially birth weight. METHODS: Prospective and retrospective observational studies found in PubMed, MEDLINE, Embase, Google Scholar, and WangFang database were included in this meta analysis...
May 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28478441/application-of-hanging-drop-technique-for-kidney-tissue-culture
#9
Shaohui Wang, Ximing Wang, Jasmine Boone, Jin Wie, Kay-Pong Yip, Jie Zhang, Lei Wang, Ruisheng Liu
BACKGROUND/AIMS: The hanging drop technique is a well-established method used in culture of animal tissues. However, this method has not been used in adult kidney tissue culture yet. This study was to explore the feasibility of using this technique for culturing adult kidney cortex to study the time course of RNA viability in the tubules and vasculature, as well as the tissue structural integrity. METHODS: In each Petri dish with the plate covered with sterile buffer, a section of mouse renal cortex was cultured within a drop of DMEM culture medium on the inner surface of the lip facing downward...
May 4, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28478435/angiogenesis-and-inflammation-in-peritoneal-dialysis-the-role-of-adipocytes
#10
Jun Shi, Manshu Yu, Meixiao Sheng
Chronic inflammation and angiogenesis are the most common complications in patients undergoing maintenance peritoneal dialysis (PD), resulting in progressive peritoneum remolding and, eventually, utrafiltration failure. Contributing to the deeper tissue under the peritoneal membrane, adipocytes play a neglected role in this process. Some adipokines act as inflammatory and angiogenic promoters, while others have the opposite effects. Adipokines, together with inflammatory factors and other cytokines, modulate inflammation and neovascularization in a coordinated fashion...
May 4, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28478454/vascular-endothelial-growth-factor-augments-arginine-transport-and-nitric-oxide-generation-via-a-kdr-receptor-signaling-pathway
#11
Moshe Shashar, Tamara Chernichovski, Oren Pasvolsky, Sharon Levi, Ayelet Grupper, Rami Hershkovitz, Talia Weinstein, Idit F Schwartz
BACKGROUND/AIMS: Vascular endothelial growth factor (VEGF) is an endothelium-specific peptide that stimulates angiogenesis via two receptor tyrosine kinases, Flt-1 and KDR. Endothelial nitric oxide synthase (eNOS) plays a major role in VEGF signaling. Delivery of arginine to membrane bound eNOS by the cationic amino acid transporter-1 (CAT-1) has been shown to modulate eNOS activity. The current studies were designed to test the hypothesis that VEGF enhances eNOS activity via modulation of arginine transport by CAT-1...
May 3, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28494444/associations-of-usual-24-hour-sodium-and-potassium-intakes-with-blood-pressure-and-risk-of-hypertension-among-adults-in-china-s-shandong-and-jiangsu-provinces
#12
Jianwei Xu, Xiaorong Chen, Zeng Ge, Hao Liang, Liuxia Yan, Xiaolei Guo, Yongqing Zhang, Linhong Wang, Jixiang Ma
BACKGROUND/AIMS: High sodium intake and low intake of potassium can increase blood pressure (BP) and risk of developing hypertension. Few studies have examined the association between 24-h urinary sodium and potassium excretion and BP or risk of hypertension in China, and most used only a single 24-h urinary sample. METHODS: We analyzed data on 2281 participants aged 18-69 years by using two 24-h urinary sodium and potassium excretions from the supplemental baseline survey of the Shandong-Ministry of Health Action on Salt Reduction and Hypertension (SMASH) project...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28437782/detection-of-renal-hypoxia-in-lupus-nephritis-using-blood-oxygen-level-dependent-mr-imaging-a-multiple-correspondence-analysis
#13
Huilan Shi, Tiekun Yan, Dong Li, Junya Jia, Wenya Shang, Li Wei, Zhenfeng Zheng
BACKGROUND/AIMS: Nephrologists have pursued ideal, dynamic and noninvasive methods for assessing renal function and disease progression. Blood oxygen level dependent (BOLD) imaging is a useful technique for assessing renal disease. This current study was performed to explore the correlation between the hypoxia iconographical index and renal pathological features in lupus nephritis. METHODS: Adult patients with lupus nephritis (LN) and healthy volunteers were recruited for this study...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28427080/rapamycin-induces-autophagy-and-reduces-the-apoptosis-of-podocytes-under-a-stimulated-condition-of-immunoglobulin-a-nephropathy
#14
Shikai Liang, Juan Jin, Bo Lin, Jianguang Gong, Yiwen Li, Qiang He
Backgroud/Aims: The aim of this study was to investigate the potential renoprotective effect of rapamycin on the autophagy of podocytes treated with the supernatant of mesangial cells cultured with aggregated IgA1 (aIgA1) from immunoglobulin A nephropathy (IgAN) patients. METHODS: Monomeric IgA1 (mIgA1) was isolated from the serum of IgAN patients or healthy volunteers, and then transformed to aIgA1 by heating. Subsequently, the aIgA1-mesangial cell supernatant was prepared by collecting the medium of mouse mesangial cells (MSC1097) cultured with aIgA1 (100 mg/L) from different IgAN patients or healthy volunteers for 48 h...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28395294/treatment-of-persistent-gross-hematuria-with-tranexamic-acid-in-autosomal-dominant-polycystic-kidney-disease
#15
Qing Yao, Ming Wu, Jie Zhou, Meiyang Zhou, Dongping Chen, Lili Fu, Rongrong Bian, Xiaohong Xing, Lijun Sun, Xiaohong Hu, Lin Li, Bing Dai, Rudolf P Wüthrich, Yiyi Ma, Chang-Lin Mei
BACKGROUND/AIMS: In this retrospective study we aimed to compare the effect of tranexamic acid (TXA) vs etamsylate, two hemostatic agents, on hematuria duration in autosomal dominant polycystic kidney disease (ADPKD) patients with persistent gross hematuria. METHODS: This is a retrospective study of 40 patients with ADPKD and macroscopic hematuria. 20 patients receiving TXA and snake venom blood clotting enzyme injection were compared with 20 matched patients receiving etamsylate and snake venom blood clotting enzyme injection...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28395289/urinary-angiotensinogen-and-renin-excretion-are-associated-with-chronic-kidney-disease
#16
Annett Juretzko, Antje Steinbach, Anke Hannemann, Karlhans Endlich, Nicole Endlich, Nele Friedrich, Uwe Lendeckel, Sylvia Stracke, Rainer Rettig
BACKGROUND/AIMS: Several studies sought to identify new biomarkers for chronic kidney disease (CKD). As the renal renin-angiotensin system is activated in CKD, urinary angiotensinogen or renin excretion may be suitable candidates. We tested whether urinary angiotensinogen or renin excretion is elevated in CKD and whether these parameters are associated with estimated glomerular filtration rate (eGFR). We further tested whether urinary angiotensinogen or renin excretion may convey additional information beyond that provided by albuminuria...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28395286/heart-failure-with-preserved-and-reduced-ejection-fraction-in-hemodialysis-patients-prevalence-disease-prediction-and-prognosis
#17
Marlies Antlanger, Stefan Aschauer, Chantal Kopecky, Manfred Hecking, Johannes J Kovarik, Johannes Werzowa, Julia Mascherbauer, Bernd Genser, Marcus D Säemann, Diana Bonderman
BACKGROUND/AIMS: Heart failure (HF) is a main cause of mortality of hemodialysis (HD) patients. While HF with reduced ejection fraction (HFrEF) is known to only affect a minority of patients, little is known about the prevalence, associations with clinical characteristics and prognosis of HF with preserved ejection fraction (HFpEF). METHODS: We included 105 maintenance HD patients from the Medical University of Vienna into this prospective single-center cohort study and determined the prevalence of HFpEF (per the 2013 criteria of the European Society of Cardiology) and HFrEF (EF <45%), using standardized post-HD transthoracic echocardiography...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28391282/association-between-ifn-%C3%AE-gene-polymorphisms-and-iga-nephropathy-in-a-chinese-han-population
#18
Jie Gao, Linting Wei, Xinghan Liu, Li Wang, Dan Niu, Tianbo Jin, Ganglian Yao, Meng Wang, Qiaoling Yu, Rongguo Fu
BACKGROUND/AIMS: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. METHODS: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28359068/the-effect-of-combined-treatment-with-the-pro-renin-receptor-blocker-hrp-and-quinapril-in-type-1-diabetic-rats
#19
Gábor Kökény, Lilla Fang, Csaba Révész, Miklós M Mózes, Péter Vörös, Gábor Szénási, László Rosivall
BACKGROUND/AIMS: Diabetic nephropathy remains a major clinical problem. The effects of prorenin might be adverse, but the literature data are controversial. We compared the renal effects of the (pro)renin receptor ((P)RR) blockade and angiotensin converting enzyme (ACE) inhibition on the progression of diabetic nephropathy in rats. METHODS: Diabetes (DM) was induced by ip. streptozotocin administration in adult male Sprague-Dawley rats, followed by eight weeks of treatment with the (P)RR blocker "handle region" decoy peptide (HRP, 0,1 mg/kg/day) or with the ACE inhibitor Quinapril (Q, 50 mg/kg/day) and grouped as follows: 1...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28359064/interleukin-17a-and-toll-like-receptor-4-in-patients-with-arterial-hypertension
#20
Tihana Simundic, Bojan Jelakovic, Andrea Dzumhur, Tajana Turk, Ines Sahinovic, Blazenka Dobrosevic, Boris Takac, Jerko Barbic
BACKGROUND/AIMS: Immune responses are involved in arterial hypertension. An observational cross-sectional case control study was conducted to estimate the association between Toll-like receptor 4 (TLR4) expression and interleukin (IL)-17A serum levels in patients with controlled and non-controlled hypertension. METHODS: We have enrolled 105 non-complicated otherwise healthy hypertensive patients: 53 with well-controlled blood pressure and 52 non-controlled. TLR4 peripheral monocytes expression and serum IL-17A levels were determined by flow cytometry and ELISA, respectively...
2017: Kidney & Blood Pressure Research
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