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Kidney & Blood Pressure Research

Karin J R Ipema, Johanna Kuipers, Ralf Westerhuis, Carlo A J M Gaillard, Cees P van der Schans, Wim P Krijnen, Casper F M Franssen
BACKGROUND/AIMS: Higher interdialytic weight gain (IDWG) is associated with higher predialysis blood pressure and increased mortality. IDWG is also increasingly being recognized as an indicator of nutritional status. We studied in detail the associations of various patient factors and nutritional parameters with IDWG. METHODS: We collected data during one week for IDWG and hemodynamic parameters in 138 prevalent adult haemodialysis patients on a thrice-weekly haemodialysis schedule...
October 14, 2016: Kidney & Blood Pressure Research
Bernd Hewing, Anna Maria Dehn, Oliver Staeck, Fabian Knebel, Sebastian Spethmann, Karl Stangl, Gert Baumann, Henryk Dreger, Klemens Budde, Fabian Halleck
BACKGROUND/AIMS: Cardiac changes observed in chronic kidney disease patients are of multifactorial origin including chronic uremia, hemodynamics or inflammation. Restoration of renal function by kidney transplantation (KTX) may reverse cardiac changes. Novel echocardiographic methods such as speckle tracking echocardiography (STE) allow early and sensitive detection of subtle changes of cardiac parameters. We evaluated changes of cardiac structure and function after KTX by advanced echocardiographic modalities...
October 10, 2016: Kidney & Blood Pressure Research
Xiaoqin Liu, Yi Guan, Sheng Xu, Qingzhao Li, Yuanbo Sun, Ruijie Han, Chunyang Jiang
Accompanied with the broad application of interventional therapy, the incidence of acute kidney injury (AKI) has been recently increasing in clinical renal medicine. The pathogenesis of AKI is diverse and complex. In the context of the requirements for the diagnosis and treatment of a renal disorder, a large number of studies have explored biological markers and their usefulness to the early diagnosis and treatment of AKI, including glomerular injury, renal tubular injury, and others. These biomarkers provide an important basis for early monitoring of AKI, but are still not quite sufficient...
September 28, 2016: Kidney & Blood Pressure Research
Wenxue Hu, Wenna He, Wei Liu, Xiaowu Fang, Yanhua Wu, Feng Yu, Wenke Hao
BACKGROUND/AIMS: Cardiorenal syndrome type 1 (CRS1) is a syndrome characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims of this study were to investigate the risk factors and the prognosis of CRS1 in elderly patients. METHODS: A total of 312 elderly patients (≥60 years old) with acute heart failure (AHF) were studied. They were assigned as CRS1 (suffered from in-hospital AKI) or NCRS1 (without AKI) group. Clinical and laboratory data were recorded...
September 28, 2016: Kidney & Blood Pressure Research
Usama Elewa, Maria D Sanchez-Niño, Ignacio Mahillo-Fernández, Catalina Martin-Cleary, Ana Belen Sanz, Maria Vanessa Perez-Gomez, Beatriz Fernandez-Fernandez, Alberto Ortiz
BACKGROUND/AIMS: Chronic kidney disease and, specifically, diabetic kidney disease, is among the fastest increasing causes of death worldwide. A better understanding of the factors contributing to the high mortality may help design novel monitoring and therapeutic approaches. CXCL16 is both a cholesterol receptor and a chemokine with a potential role in vascular injury and inflammation. We aimed at identifying predictors of circulating CXCL16 levels in diabetic patients with chronic kidney disease...
September 26, 2016: Kidney & Blood Pressure Research
Silvia Lai, Mauro Ciccariello, Mira Dimko, Alessandro Galani, Silvio Lucci, Rosario Cianci, Amalia Mariotti
: Bakground/Aims: Cardiovascular diseases represent the leading causes of morbidity and mortality in patients with cronich kidney disease (CKD). The pathogenesis includes a complex, bidirectional interaction between heart and kidney termed cardiorenal syndrome type 4. The aim of study was to evaluate the association between renal and cardiovascular ultrasonographic parameters and identify early markers of cardiovascular risk. METHODS: A total of 35 patients with CKD and 25 healthy controls, were enrolled and we have evaluated inflammatory indexes, mineral metabolism, renal function, renal and cardiovascular ultrasonographic parameters...
September 26, 2016: Kidney & Blood Pressure Research
You Ke, Hui Tang, Chen Ye, Chun-Tao Lei, Yu-Mei Wang, Hua Su, Chun Zhang, Hua-Jun Jiang
BACKGROUND/AIMS: Caspases, an evolutionary conserved family of aspartate-specific cystein proteases, play pivotal roles in apoptotic and inflammatory signaling. Thus far, 14 mammalian caspases are identified and categorized into 3 distinct sub-types: inflammatory caspases, apoptotic initiator and apoptotic executioner. Caspase-1 is an inflammatory caspase, while caspase-7 belongs to apoptotic executioner. The roles and association of these two distinct types of caspases in renal tubulointerstitial fibrosis (TIF) have not been well recognized...
September 20, 2016: Kidney & Blood Pressure Research
Tadaatsu Imaizumi, Chikashi Yano, Akiko Numata, Koji Tsugawa, Ryo Hayakari, Tomoh Matsumiya, Hidemi Yoshida, Shojiro Watanabe, Kazushi Tsuruga, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka
BACKGROUND/AIMS: Activation of Toll-like receptor 3 (TLR3) signaling followed by type I interferon (IFN) expression is crucial in antiviral and "pseudoviral" immune reactions in renal mesangial cells (MCs). These reactions are probably involved in the pathogenesis of chronic kidney disease (CKD). However, the role of IFN-induced 35-kDa protein 35 (IFI35), a type I IFN-dependent transcript, in glomerular inflammation is unclear. Here, we aimed to investigate the expression and the role of IFI35 in IFN-β/retinoic acid-inducible gene-I (RIG-I)/CCL5 and IFN-β/melanoma differentiation-associated gene 5 (MDA5)/CXCL10 axes in MCs...
September 17, 2016: Kidney & Blood Pressure Research
Marit D Solbu, Jon V Norvik, Hilde M Storhaug, Bjørn O Eriksen, Toralf Melsom, Anne Elise Eggen, Svetlana N Zykova, Jens B Kronborg, Trond G Jenssen
BACKGROUND/AIMS: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponectin, serum uric acid (SUA) and urinary biomarkers of glomerular and tubular damage (albumin-creatinine ratio [ACR] and N-acetyl-β-D-glucosaminidase-creatinine ratio [NAG-CR]) in a large cohort from a general population...
September 14, 2016: Kidney & Blood Pressure Research
Marco Bonani, Ursina Meyer, Diana Frey, Nicole Graf, Heike A Bischoff-Ferrari, Rudolf P Wüthrich
BACKGROUND/AIMS: In a randomized controlled clinical trial in kidney transplant recipients (NCT01377467) we have recently shown that RANKL inhibition with denosumab significantly improved areal bone mineral density (aBMD) when given during the first year after transplantation. The effect of denosumab on skeletal microstructure and bone strength in kidney transplant recipients is not known. METHODS: The purpose of the present bone microarchitecture ancillary study was to investigate high-resolution peripheral quantitative computed tomography (HRpQCT) data from the distal tibia and distal radius in 24 study patients that had been randomized to receive either two injections of denosumab 60 mg at baseline and after 6 months (n=10) or no treatment (n=14)...
September 14, 2016: Kidney & Blood Pressure Research
Moritz Schanz, Dirk Pannes, Jürgen Dippon, Christoph Wasser, Mark Dominik Alscher, Martin Kimmel
BACKGROUND/AIMS: There is a growing role for emergency departments (ED) in assessing acute kidney injury (AKI) for hospital admissions but there are few studies addressing acute kidney injury biomarkers and confounding factors in the ED. Cystatin C (CysC), a newer renal biomarker, is influenced by thyroid function, inflammation and obesity. This study aims to be the first study to address the impact of these parameters in the ED. METHODS: Admitted patients (n=397) were enrolled in the ED at Robert-Bosch-Hospital, Stuttgart, Germany...
September 1, 2016: Kidney & Blood Pressure Research
Valerii Fedchenko, Arthur Kopylov, Nadezhda Kozlova, Olga Buneeva, Alexei Kaloshin, Victor Zgoda, Alexei Medvedev
BACKGROUND/AIMS: Renalase is a recently discovered flavoprotein involved in regulation of blood pressure. Altered renalase levels have been found in blood of patients with end stage renal disease. The antihypertensive effect of circulating renalase is attributed to putative FAD-dependent monoamine oxidase activity demonstrated by some authors. Being synthesized as an intracellular flavoprotein renalase requires the presence of its N-terminal peptide for FAD accommodation. However, conventional routes of export of secretory proteins outside the cell usually include cleavage of their N-terminal peptide...
2016: Kidney & Blood Pressure Research
S-M Kurt Lee, Miguel A Lanaspa, Laura G Sánchez-Lozada, Richard J Johnson
BACKGROUND/AIMS: Hyponatremia associated with high urinary fractional excretion of uric acid which persists after serum sodium is corrected is the cardinal feature of salt losing nephropathy (SLN). We hypothesize that low grade proximal tubular injury is present in SLN because the proximal tubule is the main site of uric acid and sodium transport. METHODS: Five subjects with SLN were compared to four subjects with recurrent hyponatremia and three healthy individuals...
August 26, 2016: Kidney & Blood Pressure Research
Cui-Jiang Wang, You-Xia Shen, Yun Liu
BACKGROUND/AIMS: Dietary patterns, which represent whole-diet and a complex integration of food and nutrient, have been reported to play an important role in the development of hypertension. However, the results have yielded conflicting findings. Herein, we performed this meta-analysis to evaluate the associations between different dietary patterns and the likelihood of hypertension. METHODS: MEDLINE and EBSCO were searched to identify relevant articles published until the end of March 2016...
August 24, 2016: Kidney & Blood Pressure Research
Shujue Li, Wenqi Wu, Wenzheng Wu, Xiaolu Duan, Zhenzhen Kong, Guohua Zeng
BACKGROUND/AIMS: The interactions between calcium oxalate monohydrate (COM) crystals and renal tubular epithelial cells are important for renal stone formation but still unclear. This study aimed to investigate changes of epithelial cell phenotype after COM attachment and whether L-carnitine could protect cells against subsequent COM crystals adhesion. METHODS: Cultured MDCK cells were employed and E-cadherin and Vimentin were used as markers to estimate the differentiate state...
August 24, 2016: Kidney & Blood Pressure Research
Young Youl Hyun, Hyang Kim, Su-Ah Sung, Soo Wan Kim, Dong Wan Chae, Yong-Soo Kim, Kyu Hun Choi, Curie Ahn, Kyu-Beck Lee
BACKGROUND/AIMS: Previous studies have shown that low muscle mass is associated with arterial stiffness, as measured by pulse wave velocity (PWV), in a population without chronic kidney disease (CKD). This link between low muscle mass and arterial stiffness may explain why patients with CKD have poor cardiovascular outcomes. However, the association between muscle mass and arterial stiffness in CKD patients is not well known. METHODS: Between 2011 and 2013, 1,529 CKD patients were enrolled in the prospective Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD)...
August 24, 2016: Kidney & Blood Pressure Research
Yohko Nagai, Kazushige Nakanishi, Nobuaki Yamanaka
BACKGROUND/AIMS: We have reported that the long-term administration of angiotensin II receptor blockers (ARBs) induced unusual proliferative changes of renal afferent arteriolar smooth muscle cells (SMCs) in rats, associated with the overproduction of renin. In this study, we examined that a direct renin inhibitor (DRI: Aliskilen; Novartis Pharma Co, USA) might induce different changes on afferent arteriolar walls compared to ARBs. METHOD: Twenty one 6-weeks-old male spontaneous hypertensive rats (SHRs) were divided into the following three groups: high-dose DRI group (n=7), low-dose DRI group (n=5) and control group (n=9)...
August 24, 2016: Kidney & Blood Pressure Research
Ewelina Sikora-Grabka, Marcin Adamczak, Piotr Kuczera, Magdalena Szotowska, Paweł Madej, Andrzej Wiecek
BACKGROUND/AIMS: In women with chronic kidney disease (CKD) fertility abnormalities occur frequently. Anti-Müllerian hormone (AMH) inhibits excessive recruitment of primordial follicles. The aim of the study was to evaluate the serum AMH concentration in women on hemodialysis and after kidney transplantation (KTx). METHODS: 46 hemodialysed women and 14 with CKD about to undergo kidney transplantation were enrolled into the study. The control group consisted of 40 healthy women...
August 24, 2016: Kidney & Blood Pressure Research
Ying Liu, Ben-Chung Cheng, Wen-Chin Lee, Lung-Chih Li, Chih-Hsiung Lee, Wen Xiu Chang, Jin-Bor Chen
BACKGROUND/AIMS: Abnormal potassium profiles are common in peritoneal dialysis (PD) patients. We studied the factors associated with serum potassium profiles in incident PD patients. METHODS: Patients were enrolled from two hospital-facilitated PD centers from May 2013 to May 2016 and January 2009 to December 2015. A total of 319 incident PD patients were examined for factors associated with serum potassium profile. Average serum potassium levels were obtained for analysis during the first 3 months after PD initiation...
August 24, 2016: Kidney & Blood Pressure Research
Maria Bożentowicz-Wikarek, Aleksander Owczarek, Piotr Kocełak, Magdalena Olszanecka-Glinianowicz, Andrzej Więcek, Jerzy Chudek
BACKGROUND/AIMS: An analytical equivalence between intact fibroblasts growth factor(iFGF23) and C-terminal(cFGF23) assays is logically expected, however, numerous studies demonstrate lack of a strong association between them. Previously, we have demonstrated the increase in cFGF23 slightly precedes the increase of iFGF23 with the impairment of kidney excretory function; without actually analyzing the ratio between both assays, which are postulated to be affected by declining kidney function...
August 9, 2016: Kidney & Blood Pressure Research
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