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Kidney & Blood Pressure Research

Cheng-Jui Lin, Yin-Hsiu Chien, Thung-S Lai, Hong-Mou Shih, Yi-Chou Chen, Chi-Feng Pan, Han-Hsiang Chen, Wuh-Liang Hwu, Chih-Jen Wu
BACKGROUND/AIMS: Fabry disease (FD), a rare x-lined genetic disorder is a cause of renal deterioration. The phenotype of FD is highly variable and nonspecific, and correct diagnosis has always been delayed. We aimed to explore the prevalence and clinical presentation of FD in this high-risk male population in a Northern Taiwan medical center. METHODS: This is the first study to survey the incidence of FD in this high-risk population through the platform of a chronic kidney disease (CKD) education program in Asia...
2018: Kidney & Blood Pressure Research
Jian-Hua Liu, Long He, Zhi-Miao Zou, Zuo-Chuan Ding, Xue Zhang, Hao Wang, Ping Zhou, Lin Xie, Shuai Xing, Cheng-Zhi Yi
BACKGROUND/AIMS: The TLR/MyD88/NF-κB signaling pathway has been successfully used to treat renal interstitial fibrosis (RIF). However, the exact therapeutic mechanism is still unknown. Here, we assessed the therapeutic efficacy of TJ-M2010-2, a small molecular compound that inhibits MyD88 homodimerization, in RIF induced by ischemia reperfusion injury (IRI). METHODS: In vivo, RIF was induced in mice by IRI, and the mice were prophylactically treated with TJ-M2010-2...
2018: Kidney & Blood Pressure Research
Linpei Jia, Qiang Jia, Jingyan Yang, Rufu Jia, Hongliang Zhang
BACKGROUND/AIMS: Dysbiosis of the intestinal microbiota may accelerate the progression of chronic kidney disease (CKD) by increasing the levels of urea toxins. In recent years, probiotics have been recognized to maintain the physiological balance of the intestinal microbiota. In this study, we aim to assess the therapeutic effects of probiotics on CKD patients with and without dialysis via meta-analysis. METHODS: We conducted a meta-analysis of randomized controlled trials (RCTs) by searching the databases of Pubmed, EMBASE and Cochrane Library (No...
2018: Kidney & Blood Pressure Research
Sehoon Park, Seung Mi Lee, Joong Shin Park, Joon-Seok Hong, Ho Jun Chin, Ki Young Na, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
BACKGROUND/AIMS: The association between gestational estimated glomerular filtration rate (eGFR) and adverse pregnancy outcomes has not been fully investigated. METHODS: This observational cohort study included pregnancy cases of singleton mothers whose serum creatinine levels were measured during pregnancy at two tertiary hospitals in Korea from 2000 to 2015. Those with identified substantial renal function impairment (eGFR < 60 mL/min/1.73 m2 at baseline, during, or after pregnancy) were excluded...
2018: Kidney & Blood Pressure Research
Ying Yu, Lihong Zhang, Guang Xu, Zhenghong Wu, Qian Li, Yong Gu, Jianying Niu
BACKGROUND/AIMS: Angiotensin II type I receptor agonistic autoantibody (AT1-AA) is closely related to pre-eclampsia, which is characterized by proteinuria and hypertension. AT1-AA has been shown to enhance the effect of AngII in pre-eclampsia, such as production of endothelin-1, activation of ROS, and vasoconstriction, which are considered to be associated with hypertension; however, whether or not AT1-AA participates in podocyte damage leading to the generation of proteinuria has not been reported...
2018: Kidney & Blood Pressure Research
Eva Rodríguez, Javier Gimeno, Carlos Arias-Cabrales, Clara Barrios, Dolores Redondo-Pachón, María José Soler, Marta Crespo, Adriana Sierra-Ochoa, Marta Riera, Julio Pascual
BACKGROUND AND AIMS: Complement system seems to play an important role in the pathogenesis of Acute Kidney Injury (AKI). The aim of this study was to investigate the role of complement system in the pathogenesis of human AKI. For this purpose, we studied Membrane Attack Complex (MAC) and factor H in plasma and kidney tissue in AKI. METHODS: Plasmatic concentrations of MAC and Factor H were studied in patients with hospital-acquired AKI and their respective controls...
2018: Kidney & Blood Pressure Research
Wolfgang Pommer, Xiaoyan Su, Mengbi Zhang, Fanna Liu, Lianghong Yin
Assisted PD (assPD) is an option of home dialysis treatment for dependent end-stage renal patients and worldwide applied in different countries since more than 40 years. China and Germany shares similar trends in demographic development with a growing proportion of elderly referred to dialysis treatment. So far number of patients treated by assPD is low in both countries. We analyze experiences in the implementation process, barriers, and benefits of ass PD in the aging population to provide a model for sustainable home dialysis treatment with PD in both countries...
2018: Kidney & Blood Pressure Research
Jiawen Zhao, Jiwen Cheng, Chengyang Li, Mingbin Xu, Chenjun Ma, Lei Qin, Kai Yi, Naikai Liao
BACKGROUND/AIMS: Nephrolithiasis is one of the most prevalent diseases of the urinary system. Approximately 80% of human kidney stones are composed of calcium oxalate (CaOx), and hypercalciuria is one of the most common metabolic disorders. Emerging evidence indicates that autophagy and inflammatory responses are related to the formation of CaOx nephrolithiasis. However, the roles of autophagy and inflammation in patients with hypercalciuria remain unclear. Ethyl pyruvate (EP) displays protective effects in experimental models of many illnesses...
2018: Kidney & Blood Pressure Research
Julia Neuhaus, Frederic Bauer, Christina Fitzner, Ralf-Dieter Hilgers, Felix Seibert, Nina Babel, Adrian Doevelaar, Frank Eitner, Jürgen Floege, Thomas Rauen, Timm H Westhoff
BACKGROUND/AIMS: The addition of immunosuppression to supportive care reduces proteinuria in a subset of patients with IgA nephropathy (IgAN) but is associated with an increased rate of adverse events. The present work investigates whether urinary biomarkers are able to identify subjects who benefit from immunosuppression and to predict the progression of disease in a sub-cohort of the STOP-IgAN trial. METHODS: Urinary neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), calprotectin, and the product of tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 (TIMP2•IGFBP7) were measured in all available urine samples obtained at the time point of enrollment in the STOP-IgAN trial (n=113)...
2018: Kidney & Blood Pressure Research
Jing He, Yong-Ping Lu, Jian Li, Tao-Yuan Li, Xin Chen, Xu-Jing Liang, Wen-Jing Chen, Sai-Nan Pi, Berthold Hocher, You-Peng Chen
BACKGROUND/AIMS: The maternal and fetal Renin-Angiotensin-System is involved in the control of pregnancy outcomes such as blood pressure control and gestational age. However, very little is known about the impact of the angiotensin converting enzyme 2 (ACE2) on pregnancy outcome. We thus performed a prospective clinical observational study analyzing the association of maternal and fetal ACE2 gene rs2074192 polymorphism with fetal growth during pregnancy. METHODS: 898 singleton pregnant women were prospectively recruited...
2018: Kidney & Blood Pressure Research
Kosaku Nitta, Norio Hanafusa, Masayuki Okazaki, Mizuki Komatsu, Hiroshi Kawaguchi, Ken Tsuchiya
BACKGROUND/AIMS: Aortic arch calcification (AoAC) is frequently detected in maintenance hemodialysis (MHD) patients and is associated with cardiovascular and all-cause mortality. We investigated the factors associated with AoAC and analyzed the relationship between the factors including bone-derived biomarkers and AoAC. METHODS: We enrolled 389 stable MHD patients. AoAC was assessed using chest-X ray examination. Demographic data was collected in addition to serum levels of biochemical and bone-derived biomarkers, including sclerostin and fibroblast growth factor-23 (FGF-23)...
2018: Kidney & Blood Pressure Research
Shouci Hu, Pei Ming, Abdul Rashid Qureshi, Bengt Lindholm, Yang Bo, Hongtao Yang
BACKGROUND/AIMS: This study investigated peritonitis episodes with regard to time sequence, microbiological variation, factors associated with peritonitis and clinical outcomes in peritoneal dialysis (PD) patients. METHODS: This single-center cohort study enrolled all incident patients who met the inclusion criteria at our center from June 1, 2012 to June 30, 2015 and who were followed until June, 2017. Clinical, biochemical characteristics and detailed data on peritonitis episodes, and hospitalizations were recorded...
2018: Kidney & Blood Pressure Research
Yue-Chen Chang, Wen-Jing Xue, Wei Ji, Yang Wang, Yan-Ping Wang, Wen-Yan Shi, Li-Ya Shan, Liang Zhang, Chao-Yang Tan, Ke-Tao Ma, Li Li, Jun-Qiang Si
BACKGROUND/AIMS: This experimental study aims to observe whether the protective effect of propofol against renal ischemia-reperfusion injury (IRI) in the rat interlobar artery occurs through altered expression of the gap junction protein connexin 43 (Cx43). METHODS: This study randomly divided male Sprague Dawley (SD) rats into an untreated control group, a sham-operated control group (sham group), an ischemia-reperfusion group (IR group), a propofol group (propofol+IR group) and a fat emulsion group (Intralipid group)...
2018: Kidney & Blood Pressure Research
Shanshan Liang, Sixiu Liu, Hua Liu, Xin He, Lingshuang Sun, Lei Chen, Meng Wei, Fanfan Gao, Hongli Jiang
BACKGROUND/AIMS: Previous studies have shown that homocysteine (Hcy) is an important intestinal-derived uremic toxin. However, whether Hcy is involved in the epithelial barrier dysfunction observed in uremia remains unclear. This study aimed to investigate the effect of Hcy on intestinal permeability and intestinal barrier structure and function in adenine-induced uremic rats. METHODS: Sprague-Dawley rats were divided into five groups: normal control (group NC), Hcy (group H), uremia (group U), uremia + Hcy (group UH), and uremia + Hcy + VSL#3 (group UHV)...
2018: Kidney & Blood Pressure Research
Steffen Bobka, Nadja Ebert, Eloed Koertvely, Johannes Jacobi, Michael Wiesener, Maike Büttner-Herold, Kerstin Amann, Christoph Daniel
BACKGROUND/AIMS: Complement activation is important in post-transplantation renal injury, but data on its role as predictor of transplant outcome/complications when assessed in donor kidneys are lacking. METHODS: In human renal transplant biopsies with delayed graft function (DGF, n=12), antibody mediated rejection (ABMR, n=8), T-cell mediated rejection (TCMR, n=11), 1 year protocol biopsies (control, n=10) and corresponding zero-biopsies we performed immunohistochemical analyses of 6 complement factors using FFPE sections and correlated the findings with kidney function, as assessed by serum creatinine, and morphological changes including interstitial fibrosis and tubular atrophy (IF/TA)...
2018: Kidney & Blood Pressure Research
Shohei Yamamoto, Ryota Matsuzawa, Yoshifumi Abe, Keika Hoshi, Kei Yoneki, Manae Harada, Takaaki Watanabe, Takahiro Shimoda, Yuta Suzuki, Yusuke Matsunaga, Kentaro Kamiya, Atsushi Yoshida, Atsuhiko Matsunaga
BACKGROUND/AIMS: Several clinical practice guidelines recommend regular assessment of physical activity and physical function as part of routine care in hemodialysis patients. However, there is no clear evidence to support these recommendations. We investigated whether the proportion of attendance at a regular program for management of physical activity and physical function can predict all-cause mortality and cardiovascular events in hemodialysis patients. METHODS: This retrospective cohort study consisted of 266 hemodialysis patients participating in the management program at least once...
2018: Kidney & Blood Pressure Research
Tao Zhang, Yitian Dou, Xuejun Wang, Jing Li, Shili Cao
BACKGROUND/AIMS: Mounting clinical experience and evidence from scale observational studies have suggested that polycystic kidney disease (PKD) was not a contraindication for peritoneal dialysis (PD). Recent studies have reported that PD may be associated with a better prognosis in PKD than that of non-PKD patients. To solve the problem, we performed a systematic review and comprehensive meta-analysis to compare the outcomes between PKD and non-PKD patients on PD and the all-cause mortality between patients with PKD on PD and hemodialysis (HD)...
2018: Kidney & Blood Pressure Research
Flore Duranton, Alfonso Palma, Bernd Stegmayr, Michel Wauthier, Armando Torres, Àngel Argilés
BACKGROUND/AIMS: Climate influences the regulation of blood pressure (BP). Our objective was to precisely estimate BP seasonality in hemodialysis (HD) patients from five European cities with marked climate differences. METHODS: Stable prevalent HD patients from 5 European facilities (Santa Cruz de Tenerife (Spain), Seville (Spain), Montpellier (France), Ottignies (Belgium), Umea (Sweden)) present over the years 1995-1999 were included in this historical longitudinal observational study...
2018: Kidney & Blood Pressure Research
Cheng-Chieh Lin, Kuo-Tung Tang, Chia-Ing Li, Chiu-Shong Liu, Ming-May Lai, Wen-Yuan Lin, Cheng-Chieh Lin
BACKGROUND/AIMS: Brachial-ankle pulse wave velocity (baPWV) reflects the stiffness of muscular arteries. Albuminuria is recognized as a marker of vascular dysfunction. We assessed the association between arterial stiffness and albuminuria in a population-based longitudinal study. METHODS: 1116 adults aged ≥ 40 years in the Taichung Community Health Study (TCHS) in 2004 attended a follow-up visit in 2011. Albuminuria was defined as an urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g...
2018: Kidney & Blood Pressure Research
Guibao Ke, Junlin Huang, Yue Zhu, Jia Yang, Yamei Zhang, Lvlin Chen, Juan Hu, Shaoqiang Tao, Yao Hu, Dehua Yang, Shuangxin Liu
BACKGROUND/AIMS: Hemodialysis (HD) patients often have inadequate nutrition, especially with respect to ascorbic acid (AA). It is reported that every HD session may cause a 50%- 75% decrease in plasma AA levels. Some studies have shown that supplementation of AA can change the outcome of chronic kidney disease-mineral bone disorders (CKD-MBD), but the effect of AA on HD patients with CKD-MBD remains controversial. Consequently, we decided to perform a meta-analysis to evaluate the efficacy of AA supplementation in CKD-MBD patients requiring dialysis...
2018: Kidney & Blood Pressure Research
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