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Kidney & Blood Pressure Research

Lea Katalinic, Branimir Krtalic, Bojan Jelakovic, Nikolina Basic-Jukic
BACKGROUND/AIMS: There is a growing body of evidence that the long-term hemodialysis (HD) treatment leads to disturbances of carnitine homeostasis but the results of L-carnitine supplementation in HD patients have been conflicting. In the present prospective study, we investigated the effectiveness of intravenous L-carnitine in mitigating dialysis-related protein-energy wasting (PEW) based on pre-treatment albumin levels. METHODS: Fifty patients (46% male, mean age 63±18...
July 17, 2018: Kidney & Blood Pressure Research
Chi Chen, Fangzhen Xia, Yi Chen, Kun Zhang, Jing Cheng, Qin Li, Bing Han, Li Zhao, Chunfang Zhu, Ningjian Wang, Yingli Lu
BACKGROUND/AIMS: Increasing evidence suggests an association between thyroid-stimulating hormone (TSH) and estimated glomerular filtration rate (eGFR). We conducted a Mendelian randomization (MR) analysis to examine the causality of the association between TSH and eGFR. METHODS: 10,603 participants were recruited from the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China), which was performed in 23 sites in East China during 2014-2016...
July 17, 2018: Kidney & Blood Pressure Research
Yiping Ruan, Fuyuan Hong, Jiabin Wu, Miao Lin, Chen Wang, Fayang Lian, Fang Cao, Guokai Yang, Meizhu Gao
BACKGROUND/AIMS: The aim of the study was to investigate clinicopathological characteristics, the role of immunosuppressive therapy and renal outcome in IgA nephropathy (IgAN) patients with hyperuricemia. METHODS: 206 biopsy-proven primary IgAN patients were included between January 2010 and December 2015, and divided into two groups: patients without hyperuricemia (n=122), and patients with hyperuricemia (n=84). The clinicopathological features, response, renal outcome and safety were recorded...
July 17, 2018: Kidney & Blood Pressure Research
Jing-Fei Teng, Kai Wang, Zhuo-Min Jia, Yan-Jie Guo, Ya-Wei Guan, Zhi-Hui Li, Xing Ai
BACKGROUND/AIMS: Renal reperfusion injury occurs after the blood flow to the ischemic kidney is re-established under various clinical conditions, such as organ transplantation, renal artery stenosis, embolic disease, and the repair of descending aortic. The current study aims to explore the effects of src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP-2) on the release of inflammatory cytokines and the apoptosis of renal tubular epithelial cells by regulating the TLR4/NF-κB signaling pathway in rats with renal ischemia-reperfusion (I/R) injury...
July 10, 2018: Kidney & Blood Pressure Research
Xinghui Lin, Leyi Gu, Mingli Zhu, Miaolin Che, Zanzhe Yu, Hong Cai, Zhaohui Ni, Weiming Zhang
BACKGROUND/AIMS: Twice-weekly hemodialysis(HD) is prevalent in the developing countries, scarce data are available for this treatment in patients with long-term dialysis vintage. METHODS: 106 patients with more than 5 years HD vintage undergoing twice-weekly HD or thrice-weekly HD in a hemodialysis center in Shanghai between December 1, 2013 and December 31, 2013 were enrolled into the cohort study with 3 years follow-up. Kaplan-Meier analysis and Cox proportional hazards models were used to compare patient survival between the two groups...
July 10, 2018: Kidney & Blood Pressure Research
Kunlin Wang, Kaipeng Xie, Liubao Gu, Bo Xu, Jihai Chen, Qinglin Lou, Yun Yu, Shan Shan, Dan Wu, Linli Dai, Cuining Hu, Zhixiang Shen, Wei Tang
BACKGROUND/AIMS: We aimed to explore whether thyroid function within a normal range is associated with the estimated glomerular filtration rate (eGFR) and the incidence of chronic kidney disease (CKD) in a large Chinese population. METHODS: We conducted a cross-sectional study that included 10,859 euthyroid individuals who underwent an annual regular health checkup in Jiangsu Province Official Hospital between August 2012 and August 2013. We measured the thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) levels using a Roche modular analytics E170 and then calculated the eGFR using the Chinese modified Modification of Diet in Renal Disease (CMDRD) equation...
July 5, 2018: Kidney & Blood Pressure Research
Pavlos Kashioulis, Jaana Lundgren, Emman Shubbar, Lisa Nguy, Aso Saeed, Cecilia Wallentin Guron, Gregor Guron
BACKGROUND/AIMS: Cardiovascular disease is the major cause of death in patients with chronic kidney disease (CKD). Rats with adenine-induced chronic renal failure (ACRF) develop severe renal insufficiency and metabolic abnormalities that closely resemble those in patients with uremia. The aim of the present study was to determine left ventricular (LV) morphology and function in rats with ACRF. METHODS: Male Sprague-Dawley rats received either chow containing adenine or were pair-fed an identical diet without adenine (controls, C)...
July 3, 2018: Kidney & Blood Pressure Research
Ying Yu, Sheng Peng, Zhongran Cen, Jing Cai, Wei Wang, Ying Tang, Meng Du, Zhanguo Liu, Ping Chang
BACKGROUND/AIMS: Continuous renal replacement therapy (CRRT) is a treatment for acute kidney injury (AKI) patients. It has become a controversy about whether patients with liver dysfunction should perform CRRT with regional citrate anticoagulation (RCA). METHODS: This retrospective observational study enrolled 145 AKI patients (275 CRRT sessions) who received CRRT with RCA and had no history of chronic liver disease. Circuit survival time, blood pressure, trans-membrane pressure (TMP), acid-base and electrolyte status were recorded and analyzed...
July 3, 2018: Kidney & Blood Pressure Research
Wenjuan Wu, Yanhai Cui, Juan Hu, Ruyi Liao, Sijia Li, Liyi Mo, Lixia Xu, Yuanhan Chen, Zhiwen Lian, Xiulan Tian, Zhuo Li, Ruizhao Li, Li Zhang, Huaban Liang, Jianchao Ma, Ting Lin, Zhonglin Feng, Wei Dong, Guibao Ke, Pingjiang Ge, Zhiming Ye, Wenjiang Wang, Bing Zhang, Wei Shi, Xinling Liang, Shuangxin Liu
BACKGROUND/AIMS: Cardiovascular disease (CVD) is an important cause of morbidity and mortality in hemodialysis patients. Vascular calcification is thought to play an important role in causing CVD. Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker strongly predictive of cardiovascular outcomes in the pathogenesis of diabetic patients with renal disease treated with hemodialysis. We investigated the relationship between suPAR and coronary artery calcification (CAC) in patients undergoing maintenance hemodialysis...
May 3, 2018: Kidney & Blood Pressure Research
Daniel Patschan, Ivo Buschmann, Oliver Ritter, Andreas Kribben
Acute kidney injury frequently occurs in hospitalized patients all over the world. The prognosis remains poor since specific therapies for promoting kidney regeneration/repair are still missing. In recent years cell-based strategies have improved AKI outcomes under experimental circumstances. Four groups of cells, each of them displaying certain biological and functional characteristics have been evaluated in AKI, induced Pluripotent Stem Cells (iPSCs), Spermatagonial Stem Cells (SSCs), Proangiogenic Cells (PACs) and Endothelial Colony Forming Cells (ECFCs), and Mesenchymal Stem Cells (MSCs)...
May 3, 2018: Kidney & Blood Pressure Research
Xiao-Fen Weng, Song-Tao Li, Qi Song, Qi Zhu, Dan-Dan Song, Zheng-Hong Qin, Yan Xie
BACKGROUND/AIMS: Renal ischemia-reperfusion injury (IRI) is a common consequence of acute kidney injury. Nicotinamide adenine dinucleotide phosphate (NADPH), which is derived from the pentose phosphate pathway, is essential for the proper functioning of essential redox and antioxidant defense systems. Previous studies have indicated that NADPH is responsible for protecting the brain from ischemic injury. The goal of this study was to analyze the protective function of NADPH in renal IRI...
May 3, 2018: Kidney & Blood Pressure Research
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2018: Kidney & Blood Pressure Research
Rafal Donderski, Paweł Stróżecki, Beata Sulikowska, Magdalena Grajewska, Ryszard Trafny, Magdalena Bodnar, Andrzej Marszałek, Anna Stefańska, Joanna Siódmiak, Grażyna Odrowąż-Sypniewska, Jacek Manitius
BACKGROUND/AIMS: Cardiovascular complications are responsible for increased mortality and morbidity in chronic kidney disease (CKD) patients. Functional and structural changes of peritoneal membrane are reported in CKD patients both on conservative treatment and on renal replacement therapy (RRT). The aim of the study was to assess the structure of peritoneal membrane small arteries (precapillary arterioles) in diabetic and non-diabetic CKD stage 5 patients before initiation of peritoneal dialysis (PD) and evaluate its relationship with heart and large arteries abnormalities and with selected biochemical parameters...
2018: Kidney & Blood Pressure Research
David Spirk, Sarah Noll, Michel Burnier, Stefano Rimoldi, Georg Noll, Isabella Sudano
BACKGROUND/AIMS: Despite availability of a broad spectrum of blood pressure (BP)-lowering drugs many hypertensive patients do not attain BP goals. We aimed to evaluate the influence of home blood pressure monitoring (HBPM) on patient's awareness and attainment of BP goals under antihypertensive treatment with irbesartan alone or in combination with hydro-chlorothiazide. METHODS: In total, 1,268 patients with arterial hypertension were enrolled in the Factors Influencing Results in anti-hypertenSive Treatment (FIRST) study by 348 general practitioners and internal medicine specialists across Switzerland...
2018: Kidney & Blood Pressure Research
Nikolina Basic-Jukic, Jason Kirincich, Bojan Jelakovic, Zeljko Kastelan
BACKGROUND/AIMS: Renal transplant recipients are exposed to immunosuppressive treatment which may increase the risk for developing malignancies. Limited data exists concerning the occurrence of multiple primary malignancies (MPM) in renal transplant patients. METHODS: All the patients who received a renal allograft at our institution from 1973 to 2017 were included in this investigation. Data from patients with more MPM were obtained from the charts and medical records...
2018: Kidney & Blood Pressure Research
Madoka Sato, Norio Hanafusa, Hiroshi Kawaguchi, Ken Tsuchiya, Kosaku Nitta
BACKGROUND/AIMS: Potential relationships between serum sclerostin levels and the levels of bone metabolic markers in maintenance hemodialysis (MHD) patients have yet to be evaluated. This study sought to determine whether serum sclerostin levels are associated with mortality in MHD patients. METHODS: We measured serum sclerostin levels in a Japanese MHD cohort, classified the patients into tertiles according to these levels, and followed their course for a 42-month period...
2018: Kidney & Blood Pressure Research
Manshu Yu, Jun Shi, Meixiao Sheng
Fibrosis and angiogenesis are the most common processes that result in progressive peritoneal tissue remodeling and, eventually, peritoneal membrane dysfunction. The role of exosomes, which contributes to intercellular communication, in these processes has been neglected. Various biomolecules, including DNA, mRNA, proteins, lipids, and particular certain miRNAs, can be transferred by exosomes to local, neighboring and distal cells. Upon stimulation by cytokines or other microenvironment stimuli, donor cells release a mass of exosomes to peritoneal mesothelial cells, further affecting fibrosis and angiogenesis...
2018: Kidney & Blood Pressure Research
Chor Ho Jo, Sua Kim, Joon-Sung Park, Gheun-Ho Kim
BACKGROUND/AIMS: Dipeptidyl peptidase-4 (DPP4) inhibitors are known to have a protective effect on diabetic kidney disease, possibly via reduction of oxidative stress and inflammation in the kidney. However, whether these potential mechanisms play a role in non-diabetic proteinuric kidney diseases is not clear. METHODS: Two different animal experiments were carried out using sitagliptin and linagliptin for DPP4 inhibition. In each experiment, male Sprague-Dawley rats were uninephrectomized and randomly divided into vehicle-treated and doxorubicin-treated rats, with or without DPP4 inhibition...
2018: Kidney & Blood Pressure Research
Cheng-Hao Weng, Ching-Chih Hu, Tzung-Hai Yen, Ching-Wei Hsu, Wen-Hung Huang
BACKGROUND/AIMS: Uremic pruritus (UP) is an unpleasant complication in patients undergoing maintenance dialysis. Cardiovascular and infection related deaths are the major causes of mortality in patients undergoing dialysis. Studies on the correlation between cardiovascular or infection related mortality and UP are limited. METHODS: We analyze 866 maintenance hemodialysis (MHD) patients in our hemodialysis centers. Clinical parameters and 24-month cardiovascular and infection-related mortality are recorded...
2018: Kidney & Blood Pressure Research
Agnieska Ćwiklińska, Monika Cackowska, Ewa Wieczorek, Ewa Król, Robert Kowalski, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwińska, Kamil Dąbkowski, Justyna Zielińska, Alicja Dębska-Ślizień, Maciej Jankowski
BACKGROUND/AIMS: Hypertriglyceridaemia (HTG) and reduction and dysfunction of high density lipoprotein (HDL) are common lipid disturbances in chronic kidney disease (CKD). HTG in CKD is caused mainly by the decreased efficiency of lipoprotein lipase (LPL)-mediated very low density lipoprotein triglyceride (VLDL-TG) lipolysis. It has not been clarified whether HDL dysfunction in CKD contributes directly to HTG development; thus, the aim of this study was to assess the impact of CKD progression on the ability of HDL to enhance LPL-mediated VLDL-TG lipolysis efficiency...
2018: Kidney & Blood Pressure Research
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