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Kidney & Blood Pressure Research

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https://www.readbyqxmd.com/read/29763933/the-calcium-sensing-receptor-gene-polymorphism-rs1801725-and-calcium-related-phenotypes-in-hemodialysis-patients
#1
Alicja E Grzegorzewska, Dariusz Bednarski, Monika Świderska, Adrianna Mostowska, Paweł P Jagodziński
BACKGROUND/AIMS: The calcium-sensing receptor gene (CASR) rs1801725 variant is responsible for a non-conservative amino-acid change (A986S) in the calcium-sensing receptor cytoplasmic tail. We hypothesized that rs1801725 polymorphism might be helpful in understanding Ca-related abnormalities in HD patients. METHODS: In 1215 subjects (245 on cinacalcet), we determined the associations of rs1801725 with secondary hyperparathyroidism (sHPT)-related laboratory parameters, PTH-decreasing effect of cinacalcet hydrochloride, coronary artery disease (CAD), myocardial infarction (MI), nephrolithiasis-related ESRD, and mortality...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29763911/clinical-correlates-of-ambulatory-blood-pressure-phenotypes-at-a-tertiary-care-hospital-in-turkey
#2
Siyar Erdogmus, Sim Kutlay, Zeynep Kendi Celebi, Tolga Aydın, Damla Ors Sendogan, Gizem Kumru, Kenan Keven, Gokhan Nergizoglu, Sehsuvar Erturk, Sule Sengul
BACKGROUND/AIMS: Hypertension and its complications are major public health issues worldwide due to their association with high cardiovascular morbidity and mortality. Despite significant progress in health, the prevalence of hypertension is increasing. Ambulatory blood pressure monitoring (ABPM) is becoming increasingly important for the management of hypertension. In this study, we aimed to investigate the clinical and laboratory correlates of ambulatory blood pressure (ABP) phenotypes at a tertiary care hospital in Turkey...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29763910/different-relevance-of-peripheral-central-or-nighttime-blood-pressure-measurements-in-the-prediction-of-chronic-kidney-disease-progression-in-patients-with-mild-or-no-proteinuria
#3
Piotr Kuczera, Katarzyna Kwiecień, Marcin Adamczak, Teresa Bączkowska, Jolanta Gozdowska, Katarzyna Madziarska, Hanna Augustyniak-Bartosik, Marian Klinger, Magdalena Durlik, Eberhard Ritz, Andrzej Wiecek
BACKGROUND/AIMS: Arterial hypertension is one of the leading factors aggravating the course of chronic kidney disease (CKD). It seems that the novel parameters used in the assessment of the blood pressure (BP) load (i.e. central blood pressure, nighttime blood pressure) may be more precise in predicting the cardiovascular risk and the progression of CKD in comparison with the traditional peripheral blood pressure measurements in the office conditions. The aim of the study was to assess the impact of the central, or nighttime blood pressure on the progression of CKD in patients with mild or no-proteinuria (autosomal, dominant polycystic kidney disease or IgA nephropathy)...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29763902/prognostic-factors-of-renal-involvement-in-systemic-sclerosis
#4
Edoardo Rosato, Antonietta Gigante, Biagio Barbano, Maria Ludovica Gasperini, Rosario Cianci, Maurizio Muscaritoli
BACKGROUND/AIMS: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was to evaluate type and evolution of renal involvement for a period of five years. METHODS: 121 SSc patients (100 F, 21 M) with mean age of 54.9 ± 13.8, disease duration of 9 ± 6 years, of which 62 had a diffused form and 59 limited form were enrolled...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29763891/endothelial-progenitor-cells-and-kidney-diseases
#5
Abdullah Ozkok, Alaattin Yildiz
Endothelial progenitor cells (EPC) are bone marrow derived or tissue-resident cells that play major roles in the maintenance of vascular integrity and repair of endothelial damage. Although EPCs may be capable of directly engrafting and regenerating the endothelium, the most important effects of EPCs seem to be depended on paracrine effects. In recent studies, specific microvesicles and mRNAs have been found to mediate the pro-angiogenic and regenerative effects of EPCs on endothelium. EPC counts have important prognostic implications in cardiovascular diseases (CVD)...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29734173/soluble-urokinase-plasminogen-activator-receptor-is-associated-with-coronary-artery-calcification-and-cardiovascular-disease-in-patients-undergoing-hemodialysis
#6
Wenjuan Wu, Yanhai Cui, Juan Hu, Ruyi Liao, Sijia Li, Liyi Mo, Lixia Xu, Yuanhan Chen, Zhiwen Lian, Xiulan Tian, Zhuo Li, Ruizhao Li, Li Zhang, Huaban Liang, Jianchao Ma, Ting Lin, Zhonglin Feng, Wei Dong, Guibao Ke, Pingjiang Ge, Zhiming Ye, Wenjiang Wang, Bing Zhang, Wei Shi, Xinling Liang, Shuangxin Liu
BACKGROUND/AIMS: Cardiovascular disease (CVD) is an important cause of morbidity and mortality in hemodialysis patients. Vascular calcification is thought to play an important role in causing CVD. Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker strongly predictive of cardiovascular outcomes in the pathogenesis of diabetic patients with renal disease treated with hemodialysis. We investigated the relationship between suPAR and coronary artery calcification (CAC) in patients undergoing maintenance hemodialysis...
May 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29734169/cell-based-therapies-in-acute-kidney-injury-aki
#7
Daniel Patschan, Ivo Buschmann, Oliver Ritter, Andreas Kribben
Acute kidney injury frequently occurs in hospitalized patients all over the world. The prognosis remains poor since specific therapies for promoting kidney regeneration/repair are still missing. In recent years cell-based strategies have improved AKI outcomes under experimental circumstances. Four groups of cells, each of them displaying certain biological and functional characteristics have been evaluated in AKI, induced Pluripotent Stem Cells (iPSCs), Spermatagonial Stem Cells (SSCs), Proangiogenic Cells (PACs) and Endothelial Colony Forming Cells (ECFCs), and Mesenchymal Stem Cells (MSCs)...
May 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29734167/protective-effect-of-nicotinamide-adenine-dinucleotide-phosphate-on-renal-ischemia-reperfusion-injury
#8
Xiao-Fen Weng, Song-Tao Li, Qi Song, Qi Zhu, Dan-Dan Song, Zheng-Hong Qin, Yan Xie
BACKGROUND/AIMS: Renal ischemia-reperfusion injury (IRI) is a common consequence of acute kidney injury. Nicotinamide adenine dinucleotide phosphate (NADPH), which is derived from the pentose phosphate pathway, is essential for the proper functioning of essential redox and antioxidant defense systems. Previous studies have indicated that NADPH is responsible for protecting the brain from ischemic injury. The goal of this study was to analyze the protective function of NADPH in renal IRI...
May 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29742515/dose-response-between-cardiovascular-risk-factors-and-cardiovascular-mortality-among-incident-peritoneal-dialysis-patients
#9
Xiaoxue Zhang, Dahai Yu, Yamei Cai, Jin Shang, Rui Qin, Jing Xiao, Xing Tian, Zhanzheng Zhao, David Simmons
BACKGROUND/AIMS: Traditional cardiovascular (CV) risk factors (RFs) and their management targets may not be applicable to specific medical subpopulations, particularly dialysis patients. This study aimed to evaluate the dose-response association between measurements of RFs, cardiovascular mortality, and potential metabolic targets among Chinese patients initializing peritoneal dialysis (PD). METHODS: Risk-set sampling was applied to two population based 1: 10 case-control studies of incident PD patients, matched by age, sex and the year of initialisation of PD: a main sample (204 cases and 2,040 controls) and a replication sample (81 cases and 810 controls)...
April 23, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29698975/intrarenal-arterial-lesions-are-associated-with-higher-blood-pressure-reduced-renal-function-and-poorer-renal-outcomes-in-patients-with-iga-nephropathy
#10
Ying Zhang, Lili Sun, Suhan Zhou, Qihe Xu, Qiannan Xu, Dongyu Liu, Lu Liu, Ruimin Hu, Songxia Quan, Guolan Xing
BACKGROUND/AIMS: Arterial fibrotic intimal thickening and arteriolar hyaline are considered common pathological features in immunoglobulin A nephropathy (IgAN), whereas little is known about the acute pathological manifestations of endothelial cell injury. The aim of this study was to investigate characteristics of intrarenal arterial lesions and to estimate their prognostic values in patients with IgAN. The primary renal endpoint was a 50% reduction in estimated glomerular filtration rate (eGFR) or end-stage renal disease (ESRD)...
April 23, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29689561/urate-lowering-agents-in-asymptomatic-hyperuricemia-role-of-urine-sediment-analysis-and-musculoskeletal-ultrasound
#11
Davide Viggiano, Giuseppe Gigliotti, Gianfranco Vallone, Anna Giammarino, Michelangelo Nigro, Giovambattista Capasso
Current urate-lowering therapy (ULT) includes three direct acting drugs (allopurinol, febuxostat, Rasburicase) and at least four 'indirect' drugs with other important targets (canagliflozin, losartan, fenofibrate and sevelamer). Moreover, the alcalinization of urines using bicarbonate can be used to dissolve urate crystals and the clinician may discontinue several drugs are known to increase serum levels of uric acid, such as diuretics, aspirin, cyclosporine, theophylline, mycophenolate and ACE inhibitors. While there is a consensus to start ULT in cases of symptomatic hyperuricemia (gout, urate-nephrolithiasis), the very frequent conditions of asymptomatic hyperuricemia remains a major conundrum...
April 19, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29689548/nestin-improves-preeclampsia-like-symptoms-by-inhibiting-activity-of-cyclin-dependent-kinase-5
#12
Xu Yang, Yiling Ding, Mengyuan Yang, Ling Yu, Yun Hu, Yali Deng
BACKGROUND/AIMS: Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that is characterised by a high incidence of hypertension and proteinuria. Podocytes are involved in the formation of a split membrane, which is the last barrier preventing the leakage of protein into the urine. Nestin, a cytoskeleton protein, is expressed stably in podocytes. However, the association between the Nestin concentration in urine and the progression of PE and the role of Nestin in PE remains unclear...
April 19, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29669332/paritaprevir-ritonavir-ombitasvir-plus-dasabuvir-regimen-in-the-treatment-of-genotype-1-chronic-hepatitis-c-infection-in-patients-with-severe-renal-impairment-and-end-stage-renal-disease-a-real-life-cohort
#13
Jan Sperl, Miluse Kreidlova, Dusan Merta, Klara Chmelova, Renata Senkerikova, Sona Frankova
BACKGROUND/AIMS: Chronic hepatitis C (HCV) virus infection reactivates under immunosuppressive drugs and therefore has a negative impact on long-term survival of kidney transplant recipients. Treatment-induced clearance of hepatitis C virus (HCV) in kidney transplant candidates prevents virus reactivation after transplantation. Paritaprevir/Ritonavir/Ombitasvir with Dasabuvir (PrOD) represents a highly effective treatment regimen for HCV genotype 1 (GT1), also suitable for patients with end-stage renal disease (ESRD)...
April 13, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29669331/previous-exercise-effects-in-cisplatin-induced-renal-lesions-in-rats
#14
Heloísa D C Francescato, Lucas F Almeida, Natany G Reis, Camila M Faleiros, Marcelo Papoti, Roberto S Costa, Terezila M Coimbra
BACKGROUND/AIMS: Physical training has beneficial effects on endothelial function and can influence the regeneration of the endothelial cell. We investigated the effect of physical training on cisplatin (CP)-induced acute kidney injury and assessed the impact of training on endothelial structure and function, and on the inflammatory processes in rats. METHODS: We injected male Wistar rats subjected to previous physical training in treadmill running (trained, TR) or not (sedentary, SED) with CP (5 mg/kg) (TR+CP and SED+CP groups, respectively)...
April 13, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29642068/angiopoietin-2-renal-deterioration-major-adverse-cardiovascular-events-and-all-cause-mortality-in-patients-with-diabetic-nephropathy
#15
Yi-Chun Tsai, Chee-Siong Lee, Yi-Wen Chiu, Jia-Jung Lee, Su-Chu Lee, Ya-Ling Hsu, Mei-Chuan Kuo
BACKGROUND/AIMS: Diabetic nephropathy is the leading cause of end-stage renal disease and accounts for 30∼40% of patients requiring maintenance dialysis, thereby increasing the burden on health insurance programs. Diabetic nephropathy is also the strongest predictor of cardiovascular morbidity and mortality. The aim of this study was to examine whether angiopoietin-2 (Angpt2), a modulator of endothelial function, affects the clinical outcomes of diabetic patients. METHODS: This study enrolled 236 patients with diabetes mellitus with estimated glomerular filtration rate (eGFR) < 60ml/min/1...
April 6, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29642064/integrative-bioinformatics-analysis-provides-insight-into-the-molecular-mechanisms-of-chronic-kidney-disease
#16
Le-Ting Zhou, Shen Qiu, Lin-Li Lv, Zuo-Lin Li, Hong Liu, Ri-Ning Tang, Kun-Ling Ma, Bi-Cheng Liu
BACKGROUND/AIMS: Chronic kidney disease (CKD) is a worldwide public health problem. Regardless of the underlying primary disease, CKD tends to progress to end-stage kidney disease, resulting in unsatisfactory and costly treatment. Its common pathogenesis, however, remains unclear. The aim of this study was to provide an unbiased catalog of common gene-expression changes of CKD and reveal the underlying molecular mechanism using an integrative bioinformatics approach. METHODS: We systematically collected over 250 Affymetrix microarray datasets from the glomerular and tubulointerstitial compartments of healthy renal tissues and those with various types of established CKD (diabetic kidney disease, hypertensive nephropathy, and glomerular nephropathy)...
April 6, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29642060/metabolic-syndrome-severity-and-risk-of-ckd-and-worsened-gfr-the-jackson-heart-study
#17
Mark D DeBoer, Stephanie L Filipp, Solomon K Musani, Mario Sims, Mark D Okusa, Matthew Gurka
BACKGROUND/AIMS: The metabolic syndrome (MetS), as assessed using dichotomous criteria, is associated with increased risk of future chronic kidney disease (CKD), though this relationship is unclear among African Americans, who have lower risk for MetS but higher risk for CKD. METHODS: We performed logistic regression using a sex- and race-specific MetS-severity z-score to assess risk of incident CKD among 2,627 African-American participants of the Jackson Heart Study, assessed at baseline and 8 years later...
April 6, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29627842/high-neutrophil-to-lymphocyte-ratio-is-a-significant-predictor-of-cardiovascular-and-all-cause-mortality-in-patients-undergoing-peritoneal-dialysis
#18
Xiangxue Lu, Shixiang Wang, Guizhi Zhang, Ruifang Xiong, Han Li
BACKGROUND/AIMS: Chronic inflammation is associated with increased risk of cardiovascular death in patients with end-stage renal disease (ESRD). Although elevated neutrophil-to-lymphocyte ratio (NLR), a novel inflammatory marker, has been shown to predict cardiovascular disease and all-cause mortality in the general population, limited evidence is available for its role in ESRD. METHODS: We enrolled 86 patients undergoing peritoneal dialysis (PD) for a 36-month follow-up to investigate the association between the NLR and arterial stiffness markers, namely, carotid-femoral pulse wave velocity (cfPWV) and carotid augmentation index (AIx), and mortality in PD patients...
March 29, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29627840/lung-dysfunction-and-mortality-in-patients-with-chronic-kidney-disease
#19
Hideyuki Mukai, Pei Ming, Bengt Lindholm, Olof Heimbürger, Peter Barany, Peter Stenvinkel, Abdul Rashid Qureshi
BACKGROUND/AIMS: Lung dysfunction associates with increased mortality but the impact of chronic kidney disease (CKD) is less clear. We evaluated lung function and its association with mortality among individuals with normal to severely reduced glomerular filtration rate (GFR). METHODS: 404 individuals representing GFR category G1 (n=31; GFR >90 mL/min/1.73 m2), G2 (n=46), G3 (n=33), G4 (n=49) and G5 (n=245; GFR< 15 mL/min/1.73 m2) underwent spirometry yielding lung function indices forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and peak expiratory flow (PEF)...
March 29, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29627839/genotype-phenotype-analysis-in-pediatric-patients-with-distal-renal-tubular-acidosis
#20
Eujin Park, Myung Hyun Cho, Hye Sun Hyun, Jae Il Shin, Joo Hoon Lee, Young Seo Park, Hyun Jin Choi, Hee Gyung Kang, Hae Il Cheong
BACKGROUND/AIMS: Primary distal renal tubular acidosis (dRTA) in children is a rare genetic disorder, and three causative mutated genes have been identified: SLC4A1, ATP6V1B1, and ATP6V0A4. We analyzed the prevalence and phenotypic differences of genetic mutations in children with dRTA. METHODS: A total of 17 children with dRTA were enrolled in the study. All patients underwent genetic testing for all three candidate genes. RESULTS: Pathogenic mutations, including six novel mutations, were detected in 15 (88...
March 29, 2018: Kidney & Blood Pressure Research
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