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Kidney & Blood Pressure Research

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https://www.readbyqxmd.com/read/27894116/intrarenal-vascular-resistance-is-associated-with-a-prothrombotic-state-in-hypertensive-patients
#1
Cristiana Catena, GianLuca Colussi, Marileda Novello, Valentina Fagotto, Leonardo A Sechi
BACKGROUND/AIMS: Hypertensive nephroangiosclerosis is associated with progressive increase of intrarenal vascular resistance. In addition to blood pressure, other factors can contribute to hypertensive renal damage including a prothrombotic state. We investigated the relationship between hemostatic markers and intrarenal vascular resistance in hypertension. METHODS: In 115 untreated, nondiabetic, hypertensive subjects free of cardiovascular complications and advanced renal function impairment, we measured 24-hour creatinine clearance (GFR) and urinary albumin excretion (UAE), fasting plasma glucose, HOMA-index, and plasma levels of fibrinogen, D-dimer, prothrombin fragment 1+2, plasminogen activator inhibitor-1, homocysteine, and lipoprotein(a)...
November 29, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27889773/evaluation-of-kim-1-and-ngal-as-early-indicators-for-assessment-of-gentamycin-induced-nephrotoxicity-in-vivo-and-in-vitro
#2
Qi-Hui Luo, Meng-Lu Chen, Zheng-Li Chen, Chao Huang, An-Chun Cheng, Jing Fang, Li Tang, Yi Geng
BACKGROUND/AIMS: The aminolycoside Gentamicin is a widely used antibiotic, applied in equine medicine. Despite its clinical use, concerns remain regarding the potential toxic side-effects, such as nephrotoxicity. Early detection of renal damage is critical in preclinical drug development. This study was aimed to determine whether kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may be early indicators in the assessment of Gentamycin-induced nephrotoxicity...
November 28, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27889768/clinical-utility-of-serum-cystatin-c-in-predicting-diabetic-nephropathy-among-patients-with-diabetes-mellitus-a-meta-analysis
#3
Baoqin Zhou, Honghong Zou, Gaosi Xu
BACKGROUND/AIMS: Clinically, there is lack of predictors for diabetic nephropathy (DN) in diabetes mellitus (DM) without microalbuminuria, macroalbuminuria or retinopathy. METHODS: PubMed, Chinese Biomedical Database, Cochrane Library, EMBASE and Elsevier Database were searched from inception to August 13, 2016. Studies involving patients with DM and containing data on cystatin C measurements and the measured glomerular filtration rate (mGFR) were included. Pooled sensitivity, specificity, positive predictive value, negative predictive value and other diagnostic indices were evaluated using a random effect model...
November 28, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27871079/triptolide-attenuates-inflammatory-response-in-membranous-glomerulo-nephritis-rat-via-downregulation-of-nf-%C3%AE%C2%BAb-signaling-pathway
#4
Ying Zhou, Yan Hong, Haihua Huang
BACKGROUND/AIMS: Triptolide (TPL), a main active ingredient of Tripterygium wilfordii has been shown to exert anti-inflammatory effect. The role of TPL on glomerular diseases remains unclear. METHODS: This study aims to investigate the potential anti-inflammatory effect of TPL in rats with membranous glomerulonephritis (MGN). RESULTS: Our data showed that the pathological kidney damage was significantly alleviated by TPL treatment in MGN rats...
November 23, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27871084/olmesartan-prevents-microalbuminuria-in-db-db-diabetic-mice-through-inhibition-of-angiotensin-ii-p38-sirt1-induced-podocyte-apoptosis
#5
Junhui Gu, Ming Yang, Na Qi, Shuqin Mei, Jiejian Chen, Shuwei Song, Ying Jing, Meihan Chen, Liangliang He, Lijun Sun, Huimin Hu, Lin Li, Rudolf P Wüthrich, Ming Wu, Changlin Mei
BACKGROUND/AIMS: Blockage of the renin-angiotensin II system (RAS) prevents or delays albuminuria in diabetic patients. The aim of this study was to investigate the inhibitory mechanism of the angiotensin receptor blocker olmesartan on albuminuria in a murine model of diabetic nephropathy. METHODS: Male db/db diabetic mice were fed with placebo or 20 mg/kg olmesartan by daily gavage for 12 weeks. Conditionally immortalized mouse podocytes were treated with glucose, angiotensin II, olmesartan or p38 inhibitor s8307 in different experimental conditions after differentiation...
November 21, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27871082/self-reported-physical-activity-quality-of-life-and-psychological-status-in-relation-to-plasma-25-hydroxyvitamin-d-concentration-in-patients-treated-with-hemodialysis
#6
Alicja E Grzegorzewska, Agnieszka Izdebska, Leszek Niepolski, Wojciech Warchoł, Paweł P Jagodziński
BACKGROUND/AIMS: Vitamin D status is announced among factors that may influence physical performance and mental health. Our aim was to evaluate self-reported physical activity, quality of life, psychiatric functioning, and affects with respect to plasma 25-hydroxyvitamin D [25(OH)D] concentrations in HD patients. METHODS: The study was carried out in HD patients not receiving vitamin D supplements (n = 112). IPAQ-L, QLI-D, GHQ-28, and PANAS were used in psychological evaluations...
November 21, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27871081/renal-complications-in-patients-with-renal-infarction-prevalence-and-risk-factors
#7
Jae Hyun Kwon, Bum Jin Oh, Sang Ook Ha, Dae Yong Kim, Han Ho Do
BACKGROUND/AIMS: This study aimed to investigate the incidence and risk factors for acute kidney injury (AKI) and chronic kidney disease (CKD) in patients with renal infarction. METHODS: A single-center retrospective study was conducted from January 2005 to December 2013. Baseline and clinical characteristics of the enrolled patients with renal infarction were evaluated and analyzed according to the presence of AKI and CKD. In particular, predictors for AKI and CKD were determined using logistic regression analysis...
November 21, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27871077/impact-of-annexin-a-7-deficiency-on-fgf23-plasma-concentrations
#8
Anja T Umbach, Omar El-Attar, Dong Luo, Hajar Fakhri, Rosi Bissinger, Florian Lang
BACKGROUND/AIMS: The release of fibroblast growth factor FGF23, a powerful regulator of 1,25(OH)2D3 formation and mineral metabolism, is stimulated by store-operated Ca2+ entry (SOCE), which is accomplished by the pore forming Ca2+ release activated channel protein Orai1. Regulators of Orai1 and thus FGF23 release include serum & glucocorticoid inducible kinase SGK1, a kinase up-regulated by glucocorticosteroids. Some effects of glucocorticoids require the presence of annexin A7, such as suppression of prostaglandin E2 in gastric glands...
November 21, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27871075/comparative-effectiveness-of-renin-angiotensin-system-antagonists-in-maintenance-dialysis-patients
#9
Theresa I Shireman, Jonathan D Mahnken, Milind A Phadnis, Edward F Ellerbeck, James B Wetmore
BACKGROUND/AIMS: Whether angiotensin converting enzyme inhibitors (ACE) and angiotensin receptor blockers (ARB) are differentially associated with reductions in cardiovascular events and mortality in patients receiving maintenance dialysis is uncertain. We compared outcomes between ACE and ARB users among hypertensive, maintenance dialysis patients. METHODS: National retrospective cohort study of hypertensive, Medicare-Medicaid eligible patients initiating chronic dialysis between 1/1/2000 to 12/31/2005...
November 21, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27871085/plasma-renalase-is-not-associated-with-blood-pressure-and-brachial-ankle-pulse-wave-velocity-in-chinese-adults-with-normal-renal-function
#10
Yang Wang, Yong-Bo Lv, Chao Chu, Man Wang, Bing-Qing Xie, Lan Wang, Fan Yang, Ding-Yi Yan, Rui-Hai Yang, Jun Yang, Yong Ren, Zu-Yi Yuan, Jian-Jun Mu
BACKGROUND/AIMS: This study aimed to investigate the association of renalase with blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV) in order to better understand the role of renalase in the pathogenesis of hypertension and atherosclerosis. METHODS: A total of 344 subjects with normal kidney function were recruited from our previously established cohort in Shaanxi Province, China. They were divided into the normotensive (NT) and hypertensive (HT) groups or high baPWV and normal baPWV on the basis of BP levels or baPWV measured with an automatic waveform analyzer...
November 19, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27838691/monascus-adlay-and-monacolin-k-attenuates-arterial-thrombosis-in-rats-through-the-inhibition-of-icam-1-and-oxidative-stress
#11
An-Jan Tien, Tsung-Hung Chueh, Chih-Ping Hsia, Chiang-Ting Chien
BACKGROUND/AIMS: Monascus Adlay (MA) prepared from fungal fermentation of Monascus purpureus inoculating with cooked adlay contains high content of monakolin K (MK) and phenolic compounds. We explored whether MA and MK improve FeCl3-induced arterial thrombosis in rats. METHODS: The rats were divided into control, FeCl3-treated rat carotid artery occlusion (TTO), TTO determined with one-week MA, and TTO determined with one-week MK. We compared MA or MK effects on oxidative stress by chemiluminescence amplification and immunohistochemistry, TTO by a transonic system, NFκB, ICAM-1, endoplasmic reticulum stress CHOP and Nrf2 signaling by western blotting...
November 14, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27832660/global-overexpression-of-et-1-decreases-blood-pressure-a-systematic-review-and-meta-analysis-of-et-1-transgenic-mice
#12
Yong Ping Lu, Oleg Tsuprykov, Nicolas Vignon-Zellweger, Susi Heiden, Berthold Hocher
BACKGROUND/AIMS: ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide. To determine the net effect of these partially counteracting mechanisms on blood pressure, a systematic meta-analysis was performed. METHODS: Based on the principles of Cochrane systematic reviews, we searched in major literature databases - MEDLINE (PubMed), Embase, Google Scholar, and the China Biological Medicine Database (CBM-disc) - for articles relevant to the topic of the blood pressure phenotype of endothelin-1 transgenic (ET-1+/+) mice from January 1, 1988 to March 31, 2016...
November 11, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27832657/expression-of-bmp-2-in-vascular-endothelial-cells-of-recipient-may-predict-delayed-graft-function-after-renal-transplantation
#13
Nikolina Basic-Jukic, Marijana Gulin, Tvrtko Hudolin, Zeljko Kastelan, Lea Katalinic, Marijana Coric, Marija Varnai Veda, Vanja Ivkovic, Petar Kes, Bojan Jelakovic
BACKGROUND/AIMS: Delayed graft function (DGF) is associated with adverse outcomes after renal transplantation. Bone morphogenetic protein-2 (BMP-2) is involved in both endothelial function and immunological events. We compared expression of BMP-2 in epigastric artery of renal transplant recipients with immediate graft function (IGF) and DGF. METHODS: 79 patients were included in this prospective study. Patients were divided in IGF group (64 patients) and DGF group (15 patients)...
November 11, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27832650/gulo-acts-as-a-de-novo-marker-for-pronephric-tubules-in-xenopus-laevis
#14
Yajun Xie, Yuhang Liu, Ya Zhao, Hui Wang, Yamin Liu, Honglian Wang, Mi Li, Hui Zhao, Qin Zhou, Xiaoyan Lv
BACKGROUNDS/AIMS: Vitamin C is an antioxidant and acts as a cofactor for several key enzymatic catalytic reactions in animals. Amphibians produce vitamin C in their kidneys, as opposed to mammals that produce vitamin C in their liver. Gulo serves as a crucial enzyme for vitamin C synthesis in mammals, but the characteristics and localization of its homologous genes during kidney development in Xenopus laevis, an amphibian, remains unknown. METHODS: We aligned amino acid sequences of Gulo across different species by using bioinformatics methods and detected patterns of expression for Gulo during kidney development by using RT-PCR and in situ hybridization...
November 11, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27832647/extracellular-volume-overload-and-increased-vasoconstriction-in-patients-with-recurrent-intradialytic-hypertension
#15
Peter Noel Van Buren, Yunyun Zhou, Javier A Neyra, Guanghua Xiao, Wanpen Vongpatanasin, Jula Inrig, Robert Toto
BACKGROUND/AIMS: Intradialytic hypertension (IH) occurs frequently in some hemodialysis patients and increases mortality risk. We simultaneously compared pre-dialysis, post-dialysis and changes in extracellular volume and hemodynamics in recurrent IH patients and controls. METHODS: We performed a case-control study among prevalent hemodialysis patients with recurrent IH and hypertensive hemodialysis controls. We used bioimpedance spectroscopy and impedance cardiography to compare pre-dialysis, post-dialysis, and intradialytic change in total body water (TBW) and extracellular water (ECW), as well as cardiac index (CI) and total peripheral resistance index (TPRI)...
November 11, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27832640/roles-of-non-coding-rnas-in-acute-kidney-injury
#16
Ping Zhou, Zhi Chen, Yan Zou, Xiaoxiao Wan
Acute kidney injury (AKI) is a complex kidney disorder that leads to numerous complications, such as elevated nitrogenous wastes, metabolic acidosis, high potassium levels and even death. The pathogenesis of AKI is very complicated, and its causes are commonly categorized as prerenal, intrinsic or postrenal. In the past few years, evidence has accumulated showing that non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI...
November 11, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27788510/blood-pressure-reduction-is-associated-with-the-changes-in-oxidative-stress-and-endothelial-activation-in-hypertension-regardless-of-antihypertensive-therapy
#17
Martina Mihalj, Refmir Tadzic, Aleksandar Vcev, Silvija Rucevic, Ines Drenjancevic
BACKGROUND/AIMS: Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodium dismutase activity. This study aimed to investigate the effects of antihypertensive therapy and also vitamin C/E supplementation on BP, oxidative stress and endothelial activation in patients with essential hypertension...
October 28, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27788506/overexpression-of-intrarenal-renin-angiotensin-system-in-human-acute-tubular-necrosis
#18
Wei Cao, Lingwei Jin, Zhanmei Zhou, Manqiu Yang, Chunyi Wu, Liling Wu, Shuang Cui
BACKGROUND/AIMS: Acute tubular necrosis (ATN), a leading cause of acute kidney injury (AKI), is associated with decreased survival and increased progression of chronic kidney disease. A barrier to improving the clinical outcomes is the incomplete understanding of the pathogenesis of AKI. Our objective is to test the hypothesis that intrarenal renin-angiotensin system (RAS) is overexpressed in patients with ATN and could be an indicator of ATN severity. METHODS: A transversal study was conducted in patients with biopsy-proven ATN...
October 28, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27771713/frailty-in-chinese-peritoneal-dialysis-patients-prevalence-and-prognostic-significance
#19
Jack Kit-Chung Ng, Bonnie Ching-Ha Kwan, Kai-Ming Chow, Phyllis Mei-Shan Cheng, Man-Ching Law, Wing-Fai Pang, Chi-Bon Leung, Philip Kam-Tao Li, Cheuk-Chun Szeto
BACKGROUND/AIMS: Previous studies showed that frailty is prevalent in both pre-dialysis and dialysis patients. However, the prevalence and prognostic implication of frailty in Chinese peritoneal dialysis (PD) patients remain unknown. METHODS: We used a validated questionnaire to determine the Frailty Score of 193 unselected prevalent PD patients. All patients were then followed for 2 years for their need of hospitalization and mortality. RESULTS: Amongst the 193 patients, 134 (69...
October 24, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27676190/risk-factors-and-prognosis-of-cardiorenal-syndrome-type-1-in-elderly-chinese-patients-a-retrospective-observational-cohort-study
#20
Wenxue Hu, Wenna He, Wei Liu, Xiaowu Fang, Yanhua Wu, Feng Yu, Wenke Hao
BACKGROUND/AIMS: Cardiorenal syndrome type 1 (CRS1) is a syndrome characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). The aims of this study were to investigate the risk factors and the prognosis of CRS1 in elderly patients. METHODS: A total of 312 elderly patients (≥60 years old) with acute heart failure (AHF) were studied. They were assigned as CRS1 (suffered from in-hospital AKI) or NCRS1 (without AKI) group. Clinical and laboratory data were recorded...
September 28, 2016: Kidney & Blood Pressure Research
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