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Spinal Cord

Xiangzhe Li, Qinfeng Wu, Caizhong Xie, Can Wang, Qinghua Wang, Chuanming Dong, Lu Fang, Jie Ding, Tong Wang
STUDY DESIGN: Experimental study. OBJECTIVES: To investigate the role of BDNF-TrkB signaling that promotes the recovery of neurological function in rats with incomplete spinal cord injury (SCI) after treadmill training (TT). SETTING: Rehabilitation Medicine Center of the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. METHODS: Forty rats were divided into five groups: (i) Sham; (ii) SCI and phosphate-buffered saline (PBS) (SCI/PBS); (iii) SCI-TT/PBS; (iv) SCI/TrkB-IgG; and (v) SCI-TT/TrkB-IgG...
July 12, 2018: Spinal Cord
Emelie Butler Forslund, Vivien Jørgensen, Kirsti Skavberg Roaldsen, Claes Hultling, Kerstin Wahman, Erika Franzén
STUDY DESIGN: Prediction study. OBJECTIVES: To investigate the prediction accuracy of the Downton fall risk index (DFRI) and a question of falls the previous year; further to examine the association between time to first fall and risk indicators for falls in wheelchair users and ambulatory persons with Spinal Cord Injury (SCI). SETTING: Two SCI centres in Norway and Sweden (Sunnaas Rehabilitation Hospital, Rehab Station Stockholm /Spinalis)...
July 9, 2018: Spinal Cord
Emil Kostovski, Elena Frigato, Mladen Savikj, Anders Dahm, Per Morten Sandset, Marie-Christine Mowinckel, Grethe Skretting, Bjarne Østerud, Cristiano Bertolucci, Per Ole Iversen
STUDY DESIGN: Crossover double blind, randomized placebo-controlled trial. OBJECTIVES: Circadian oscillators are located both in the brain and in peripheral organs. Melatonin, the main brain-derived hormone governing circadian variations, is highly associated with daylight patterns. However, in subjects with tetraplegia the melatonin levels are blunted. Here we studied peripheral oscillators in peripheral blood mononuclear cells (PBMCs) in males with tetraplegia by examining how exogenous melatonin may influence the expression of clock gene mRNAs...
July 9, 2018: Spinal Cord
Jae-Hyun Yun, Seong-Min Chun, Ju-Chan Kim, Hyung-Ik Shin
STUDY DESIGN: Cross-sectional. OBJECTIVES: To determine the obesity cutoff values for body mass index (BMI) and waist circumference (WC) in Korean men with motor complete spinal cord injury (SCI). SETTING: Tertiary level hospital in Seoul, Korea. METHODS: BMI (kg/m2 ) was calculated and WC (cm) was measured in each participant in the supine position. Percentage of total body fat (%) was determined using whole-body dual-energy X-ray absorptiometry...
July 5, 2018: Spinal Cord
Andréane Richard-Denis, Cynthia Thompson, Jean-Marc Mac-Thiong
STUDY DESIGN: Prospective cohort study. OBJECTIVES: To evaluate the relationship between quality of life (QOL) after a traumatic spinal cord injury (TSCI) and acute predictors, with a particular emphasis on the initial severity of the neurological injury. Secondarily, to compare the QOL after a TSCI with the general population. SETTING: A single Level-1 SCI-trauma centre. METHODS: A cohort of 119 individuals admitted after a cervical TSCI between April 2010 and September 2016 was studied...
July 3, 2018: Spinal Cord
Jean-Marc Soler, Marie-Agnes Navaux, Jean-Gabriel Previnaire
STUDY DESIGN: Prospective study. OBJECTIVES: To analyze determinants of sexual pleasure in men with spinal cord injury (SCI). SETTING: Centre Bouffard-Vercelli, Cerbere, France. METHODS: Face to face interviews with men with chronic SCI who had an active sex life with a female partner, reliable erections permitting intercourse, and sought regular counselling with a sex therapist. Questionnaires: the International Index of Erectile Function (IIEF) and a modified Sexual History Form...
July 2, 2018: Spinal Cord
Khashayar Afshari, Amir Dehdashtian, Nazgol-Sadat Haddadi, Arvin Haj-Mirzaian, Arad Iranmehr, Mohammad Ali Ebrahimi, Seyed Mohammad Tavangar, Hedyeh Faghir-Ghanesefat, Fatemeh Mohammadi, Nastaran Rahimi, Abbas Norouzi Javidan, Ahmad Reza Dehpour
STUDY DESIGN: This is an animal study. OBJECTIVES: Metformin is a safe drug for controlling blood sugar in diabetes. It has been shown that metformin improves locomotor recovery after spinal cord injury (SCI). Neuropathic pain is also a disturbing component of SCI. It is indicated that metformin has neuroprotective and anti-inflammatory effects, which attenuate neuropathic pain and hyperalgesia in injured nerves. Thus, we evaluated metformin's therapeutic effects on SCI neuroinflammation and its sensory and locomotor complications...
June 29, 2018: Spinal Cord
J Iruthayarajah, A McIntyre, M Mirkowski, P Welch-West, E Loh, R Teasell
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To determine the risk factors predictive of dysphagia after a spinal cord injury (SCI). SETTING: None. METHODS: A comprehensive literature search was performed in five scientific databases for English articles that identified risk factors for dysphagia after a SCI in adult (≥19 years) individuals. Data extracted included: author name, year and country of publication, participant demographics, sample size, study design, method of dysphagia diagnosis, and risk factor percentages...
June 28, 2018: Spinal Cord
Bart Dekker, Olaf Verschuren, Astrid C J Balemans, Nadia Baart, Frank Tubbing, Casper F van Koppenhagen, Marcel W M Post
STUDY DESIGN: Cross-sectional exploratory study. OBJECTIVES: To determine oxygen uptake (VO2 ), energy expenditure (EE), and muscle activity (MA) during lying (rest), sitting, standing, and walking among ambulatory individuals with spinal cord Injury (SCI) and to compare VO2 , EE, and MA between individuals with different levels of ambulation. SETTING: Rehabilitation institution with a spinal cord injury unit. METHODS: A total of 22 adults with motor-incomplete SCI, ten in a low-ambulation group (non-functional or household walker) and 12 in a high-ambulation group (community or normal walker)...
June 28, 2018: Spinal Cord
Kaila A Holtz, Elena Szefer, Vanessa K Noonan, Brian K Kwon, Patricia B Mills
STUDY DESIGN: Prospective cohort study using the Rick Hansen SCI Registry (RHSCIR) and retrospective medical chart review. OBJECTIVE: To describe treatment patterns of in-patient anti-spasticity medication use following traumatic spinal cord injury (SCI) in acute and rehabilitation hospital settings in British Columbia, Canada. SETTING: Quaternary trauma center, rehabilitation center. METHODS: Individuals with traumatic SCI between 2005 and 2014 enrolled in the Vancouver RHSCIR site (N = 917) were eligible for inclusion...
June 14, 2018: Spinal Cord
Zahra Khazaeipour, Alireza Nikbakht-Nasrabadi, Nooredin Mohammadi, Alireza Salehi-Nejad, Maryam Shabany
STUDY DESIGN: This was a qualitative study conducted using an interpretative phenomenological approach. OBJECTIVES: This study investigated the experience of pregnancy and childbirth in women with spinal cord injury (SCI). SETTING: Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. METHODS: The data were collected using telecommunication and face-to-face semi-structured interviews with eight women with SCI...
June 14, 2018: Spinal Cord
Mariano G Clausi, Alexander M Stessin, Stella E Tsirka, Samuel Ryu
STUDY DESIGN: Experimental study. OBJECTIVES: To evaluate the efficacy of Angiotensin-converting enzyme inhibitor Ramipril, as a mitigator of radiation-induced spinal cord injury. SETTING: Stony Brook University, Stony Brook, NY, USA. METHODS: Total of 22 rats were irradiated with single doses of 23.6-33 Gy at the C4-T2 spinal levels. After irradiation, the rats were randomized to the radiation only control group and the Ramipril-treated (radiation + Ramipril) experimental group...
June 14, 2018: Spinal Cord
Amanda McIntyre, Brooke Benton, Shannon Janzen, Jerome Iruthayarajah, Joshua Wiener, Janice J Eng, Robert Teasell
STUDY DESIGN: Mapping Review. OBJECTIVE: The objective of this study was to map out and characterize the quantity and quality of all published spinal cord injury (SCI) randomized controlled trials (RCTs) with respect to number, sample size, and methodological quality between January 1970 and December 2016. SETTING: Not applicable. METHODS: A literature search of multiple research databases was conducted. Studies adhering to the following criteria were included: the research design was an RCT; written in English; participants were >18 years; and the sample was >50% SCI...
June 14, 2018: Spinal Cord
J Wangdell, J Fridén
STUDY DESIGN: Retrospective cohort study OBJECTIVES: To evaluate the impact of preoperative neuropathic pain on outcome and postoperative compliance after grip reconstructive surgery in people with tetraplegia. SETTING: Specialized tetraplegia upper-limb surgery center in Sweden. METHODS: All patients who underwent grip reconstructive surgery and attended a 6 month follow up during January 2012 and May 2015 were included. Participants were divided into two groups, pain group and no pain group, based on preoperative rating of experienced pain on a visual analog scale...
June 14, 2018: Spinal Cord
Jonviea D Chamberlain, Hans Peter Gmünder, Kerstin Hug, Xavier Jordan, André Moser, Martin Schubert, Martin W G Brinkhof
STUDY DESIGN: Observational cohort study. OBJECTIVES: To understand differentials in the force of mortality with increasing time since injury according to key spinal cord injury (SCI) characteristics. SETTING: Specialized rehabilitation centers within Switzerland. METHODS: Data from the Swiss Spinal Cord Injury (SwiSCI) cohort study were used to model mortality in relation to age, sex, and lesion characteristics. Hazard ratios (HRs) and adjusted survival curves were estimated using flexible parametric survival models of time since discharge from first rehabilitation to death or 30 September 2011, whichever came first...
June 12, 2018: Spinal Cord
Marcel W M Post, Jacinthe J E Adriaansen, Claudio Peter
STUDY DESIGN: Cross-sectional psychometric study. OBJECTIVES: The University of Washington Self-Efficacy Scale (UW-SES) is a measure of self-efficacy regarding managing challenges related to multiple sclerosis or spinal cord injury (SCI) that can be used across disabling conditions. The objective of this study was to examine the psychometric properties of its short form, the UW-SES-6, using the Rasch model. SETTING: Community, The Netherlands...
June 12, 2018: Spinal Cord
Anthony Gélis, Arnaud Dupeyron, Jean Pierre Daures, David Goossens, Dominique Gault, Jean Paul Pedelucq, Michel Enjalbert, Eric Maupas, Paul Kennedy, Charles Fattal, Sarah Mathieu, Toufik Bouchema
STUDY DESIGN: Cross-sectional psychometrics study. OBJECTIVES: To determine the construct validity and internal consistency of the revised Skin Management Needs Assessment Checklist (revised SMnac). SETTING: Six spinal cord rehabilitation centers. METHODS: One-hundred and thirty-two community-dwelling individuals with spinal cord injury (SCI) were included. Construct validity was assessed by a Spearman's rank correlation coefficient between the revised SMnac and several questionnaires: Rosenberg Self-Esteem Scale, Ways of Coping Questionnaire, Hospital Anxiety and Depression Scale (HADS), Braden scale; or clinical variables: educational level, presence of a pressure ulcer (PU), history of multiple PUs, time since injury, and pain...
June 12, 2018: Spinal Cord
Marlene Elmelund, Niels Klarskov, Fin Biering-Sørensen
STUDY DESIGN: Cross-sectional study. OBJECTIVES: There is a knowledge gap on urinary incontinence in women with spinal cord injury. Hence, the aim of this study was to determine the prevalence and conditions associated with urinary incontinence in this population. SETTING: Clinic for Spinal Cord Injuries, Rigshospitalet, Denmark. METHODS: Women with a spinal cord injury between September 1999 and August 2016, who attended a consultation in our clinic during August 2010-August 2016, were included...
June 12, 2018: Spinal Cord
Plínio Luna Albuquerque, Thyciane Mendonça, Mayara Campêlo, Lívia Shirahige, Kátia Monte-Silva
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVES: To summarize the available evidence regarding the effects of trans-spinal direct current stimulation (tsDCS) on spinal monosynaptic circuit excitability in healthy individuals. SETTING: Applied Neuroscience Laboratory, Brazil. METHODS: Abstract screening was performed independently by two authors for studies found in the following databases: PubMed, CINAHL, PsycINFO, Web of Science, and LILACS...
June 12, 2018: Spinal Cord
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