journal
MENU ▼
Read by QxMD icon Read
search

Medical Science Monitor: International Medical Journal of Experimental and Clinical Research

journal
https://www.readbyqxmd.com/read/30444219/increased-expression-of-c-met-is-associated-with-chemotherapy-resistant-breast-cancer-and-poor-clinical-outcome
#1
Lizhou Jia, Xiaobing Yang, Wei Tian, Siqi Guo, Wenbin Huang, Wei Zhao
BACKGROUND The relevance of c-Met expression as a prognostic or predictive clinical indicator in chemotherapy-resistant breast cancer remains unknown. The aims of this study were to investigate the expression of c-Met in breast cancer tissues and its association with expression of type II topoisomerase (TOPO II), including in patients who received neoadjuvant chemotherapy (NAC), and to investigate chemotherapy resistance in vitro in breast cancer cell lines. MATERIAL AND METHODS Tissue samples from 255 patients with breast cancer, with matched adjacent normal breast tissue, were used in tissue microarrays (TMAs)...
November 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30442880/relationship-between-fat-mass-and-obesity-associated-fto-gene-polymorphisms-with-obesity-and-metabolic-syndrome-in-ethnic-mongolians
#2
Qiang Zhang, Xiayun Xia, Shixin Fang, Xiangzhen Yuan
BACKGROUND The distribution of fat mass and obesity-associated gene (FTO) genes rs9939609 and rs1421085 in obese and normal ethnic Mongolians was analyzed to investigate the association of FTO gene polymorphisms with obesity and metabolic syndrome in ethnic Mongolians. MATERIAL AND METHODS The genotypes of FTO genes rs9939609 and rs1421085 in 500 subjects were detected by allele-specific PCR (AS-PCR). General characteristics and clinical biochemical indicators were compared between the obesity group and the control group...
November 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30439866/evaluation-of-intravenous-parecoxib-infusion-pump-of-patient-controlled-analgesia-compared-to-fentanyl-for-postoperative-pain-management-in-laparoscopic-liver-resection
#3
Yufeng Liu, Xuan Song, Dan Sun, Jiabei Wang, Yaliang Lan, Guangchao Yang, Fanzheng Meng, Yan Wang, Yifeng Cui, Bo Zhang, Xianying Li, Lianxin Liu
BACKGROUND As laparoscopic liver resection is becoming a commonly used method for hepatic surgery, postoperative pain management is emerging as one of the trickiest problems after surgery. The ideal method of pain management is controversial and the optimal strategy for postoperative pain management after surgery remains unclear. The present study evaluated the postoperative analgesic efficacy of parecoxib and fentanyl, and the benefit of a new intravenous parecoxib infusion pump with patient-controlled analgesia after laparoscopic liver resection...
November 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30431025/astrocyte-elevated-gene-1-aeg-1-acts-as-a-promoter-gene-in-clear-cell-renal-cell-carcinoma-cell-growth-and-metastasis
#4
Da Peng Yu, Yan Zhou
BACKGROUND Clear cell renal cell carcinoma (ccRCC) is usually incurable once it progresses to metastatic stage. Hence, in-depth investigations to reveal the precise molecular mechanisms behind the metastasis of ccRCC are required to improve the therapeutic outcome of ccRCC. MATERIAL AND METHODS The level of astrocyte elevated gene 1 (AEG-1) in ccRCC tissues and cell lines was determined by quantitative real-time PCR (qRT-PCR) assay. The MTS, colony formation, wound-healing, and Transwell invasion assays were used to assess the role of AEG-1 in ccRCC cells growth, migration, and invasion in vitro, respectively...
November 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30429449/comparison-of-rearranged-during-transfection-ret-gene-rearrangements-in-primary-versus-metastatic-non-small-cell-lung-cancer-nsclc
#5
Quxia Zhang, Chunwei Xu, Wenxian Wang, Meijuan Wu, Youcai Zhu, Wu Zhuang, Kaiqi Du, Yunjian Huang, Yanping Chen, Biao Wu
BACKGROUND RET rearrangements have been reported in 30% of papillary thyroid carcinomas and 1-2% of non-small cell lung cancer (NSCLC). In these tumors, RET gene fusion product provides a constitutively active tyrosine kinase (TKR), leading to uncontrolled cellular proliferation, differentiation, and migration. In this investigation we assessed the positivity rate of RET gene rearrangement in primary and metastatic non-small cell lung cancer and explored their relationships. MATERIAL AND METHODS Between January 2013 and May 2015, we collected 384 cases of primary metastatic non-small cell lung cancer, which included 246 matched metastatic tumors cases from multiple centers...
November 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30428482/epigallocatechin-gallate-is-the-most-effective-catechin-against-antioxidant-stress-via-hydrogen-peroxide-and-radical-scavenging-activity
#6
Jinting He, Lei Xu, Le Yang, Xiaofeng Wang
BACKGROUND Hydrogen peroxide-induced neuronal oxidative stress is a serious threat to the nervous system. Catechins and related compounds are effective radical scavengers that protect against nerve cell damage. MATERIAL AND METHODS Here, we investigated the antioxidant property of various catechins in protecting against hydrogen peroxide, as well as their radical-scavenging activity. RESULTS We found that catechins treatment effectively protected HT22 cells against H₂O₂-induced cell viability by decreasing and attenuating reactive oxidative species production in different proportions...
November 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30427826/high-expression-of-kif22-kinesin-like-dna-binding-protein-kid-as-a-poor-prognostic-factor-in-prostate-cancer-patients
#7
Zheng Zhang, Hui Xie, Shimiao Zhu, Xuanrong Chen, Jianpeng Yu, Tianyun Shen, Xiaoqing Li, Zhiqun Shang, Yuanjie Niu
BACKGROUND Kid (kinesin-like DNA binding protein), a member of microtubule-dependent molecular motor proteins, also known as KIF22, is reported to be associated with carcinogenesis and cancer progression in different types of malignant tumor, but the biologic behavior and clinical outcome of KIF22 in prostate cancer (PCa) has not been well studied. This study aimed to analyze the association between KIF22 and clinical outcome in PCa patients. MATERIAL AND METHODS The expression of KIF22 in tumor specimens compared with paired paracancerous tissue from 114 patients undergoing radical prostatectomy was detected by immunohistochemistry; results were verified using The Cancer Genome Atlas (TCGA) database...
November 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30426970/therapeutic-evaluation-of-radiotherapy-with-contrast-enhanced-ultrasound-in-non-resectable-hepatocellular-carcinoma-patients-with-portal-vein-tumor-thrombosis
#8
Hongxue Li, Junjie Liu, Miao Chen, Hang Li, Liling Long
BACKGROUND Therapeutic evaluation of 3-dimensional conformal radiotherapy (3DCRT) is rarely reported for non-resectable hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). The aim of this study was to determine the value of contrast-enhanced ultrasound (CEUS) in evaluating the therapeutic response of HCC with PVTT treated with 3DCRT. MATERIAL AND METHODS PVTT reduction rate in the study was determined after 3DCRT using time intensity curve (TIC) analysis software before and after radiotherapy...
November 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30425234/role-of-pyk2-in-human-cancers
#9
Ting Shen, Qiang Guo
Proline-rich tyrosine kinase 2 (Pyk2) plays essential roles in tumorigenesis and tumor progression. Pyk2 serves as a non-receptor tyrosine kinase regulating tumor cell survival, proliferation, migration, invasion, metastasis, and chemo-resistance, and is associated with poor prognosis and shortened survival in various cancer types. Thus, Pyk2 has been traditionally regarded as an oncogene and potential therapeutic target for cancers. However, a few studies have also demonstrated that Pyk2 exerts tumor-suppressive effects in some cancers, and anti-cancer treatment of Pyk2 inhibitors may only achieve marginal benefits in these cancers...
November 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30423587/efficacy-and-safety-of-botulinum-toxin-type-a-in-spasticity-caused-by-spinal-cord-injury-a-randomized-controlled-trial
#10
Xu Yan, Jie Lan, Yancheng Liu, Jun Miao
BACKGROUND Baclofen is approved by the US FDA to treat spasticity, but its sustained use may cause drug addiction. The objective of this study was to compare the efficacy and safety of botulinum toxin type A versus baclofen in spasticity. MATERIAL AND METHODS A total of 336 patients who had spasticity caused by spinal cord injury were enrolled in a randomized (in 1: 1: 1: ratio) for placebo, controlled trial. Patients had received baclofen (BA group, n=112), local intramuscular injection of 500 U Botulinum toxin type A (BTI group, n=112), or physical therapies alone (placebo group, n=112)...
November 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30422972/impact-of-hyperbaric-oxygen-on-tissue-healing-around-dental-implants-in-beagles
#11
Juan Liao, Meng-Jun Wu, Yan-Dong Mu, Peng Li, Jun Go
BACKGROUND The impact of hyperbaric oxygen (HBO) on the healing of soft tissues around dental implants was studied in a beagle model. MATERIAL AND METHODS Beagle dogs were randomized to receive implants, followed by postoperative HBO therapy or not (n=10 per group). On postoperative days 3, 7, and 14, tissue specimens were paraffin-embedded and analyzed by hematoxylin-eosin and Masson staining, as well as immunohistochemistry against CD31. RESULTS Scores for inflammation pathology based on hematoxylin-eosin staining and mean optical density of collagen fibers were significantly different between the HBO and control groups on postoperative days 3 and 7 (P<0...
November 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30421728/clinical-inertia-in-type-2-diabetes-patients-in-primary-health-care-clinics-in-central-bosnia
#12
Marijan Marjanović, Davorka Vrdoljak, Valerija Bralić Lang, Ozren Polašek, Vedran Đido, Marinka Kašćel Fišić, Ivanka Mađar Šimić, Danijela Dodig, Marina Radoš Perić
BACKGROUND The goal of this research was to determine the frequency of clinical inertia of general practice physicians in the region of Central Bosnia in healthcare for type 2 diabetes patients, to analyze characteristics of patients and physicians, as well as glucose regulation during clinical inertia, and, on the basis of these indicators, give recommendations for reducing clinical inertia. MATERIAL AND METHODS This study included 29 doctors, family physicians, or general practitioners, who collected data in a total sample of 541 type 2 diabetes mellitus patients from July to November 2017...
November 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30420588/expression-and-molecular-regulation-of-the-cox2-gene-in-gastroenteropancreatic-neuroendocrine-tumors-and-antiproliferation-of-nonsteroidal-anti-inflammatory-drugs-nsaids
#13
Feng Gao, Mohammad Ishraq Zafar, Stefan Jüttner, Michael Höcker, Bertram Wiedenmann
BACKGROUND Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has had a significant increase over the past 4 decades. The pathophysiological role of the cyclooxygenase-2 (cox-2) gene and factors responsible for the expression in GEP-NETs is of clinical value. Current study determined the expression of cox-2 gene in human GEP-NET tissues and corresponding cell lines, investigated the molecular mechanisms underlying the regulation of cox-2 gene expression and assessed the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on both anchorage-dependent and independent growth of GEP-NET cells...
November 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30419569/clinical-study-on-complications-of-intracranial-ruptured-aneurysm-embolization-by-stent-assisted-coil
#14
Yinlong Liu, Jianren Wang, Liqing Lin, Chunsheng Sang, Zexi Lin, Yaohua Pan, Xi'an Fu
BACKGROUND The aim of this study was to retrospectively analyze the incidence of complications of intracranial complex aneurysms embolization by stent-assisted coils, and to investigate the causes of complications and corresponding treatment methods. MATERIAL AND METHODS A total of 71 patients with subarachnoid hemorrhage (SAH) underwent stent-assisted coil embolization from 2015 to 2018 were enrolled in this study. Among them, 59 cases were single aneurysm, 12 cases were multiple aneurysms (11 cases with 2 aneurysms and 1 case with 3 aneurysms), for a total of 84 aneurysms...
November 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30418964/up-regulation-of-phosphatase-in-regenerating-liver-3-prl-3-contributes-to-malignant-progression-of-hepatocellular-carcinoma-by-activating-phosphatase-and-tensin-homolog-deleted-on-chromosome-ten-pten-phosphoinositide-3-kinase-pi3k-akt-signaling-pathway
#15
Bing-Hui Li, Yang Wang, Chao-Yang Wang, Ming-Juan Zhao, Tong Deng, Xue-Qun Ren
BACKGROUND The purpose of the study was to investigate the functional roles of phosphatase in regenerating liver-3 (PRL-3) in hepatocellular carcinoma (HCC), as well as the related molecular mechanisms. MATERIAL AND METHODS HCC tissues and adjacent normal tissues were collected from 124 HCC patients. The mRNA and protein levels of PRL-3 were detected using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, respectively. The relationship between PRL-3 expression and clinical characteristics of HCC patients was evaluated by chi-square test...
November 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30417859/heat-shock-protein-70-hsp70-reduces-hepatic-inflammatory-and-oxidative-damage-in-a-rat-model-of-liver-ischemia-reperfusion-injury-with-hyperbaric-oxygen-preconditioning
#16
Hsing-Hsien Wu, Chien-Cheng Huang, Ching-Ping Chang, Mao-Tsun Lin, Ko-Chi Niu, Yu-Feng Tian
BACKGROUND Several clinical conditions can cause hepatic ischemia/reperfusion (I/R) injury. This study aimed to determine the mechanism of the protective effect of hyperbaric oxygen preconditioning (HBO₂P) on hepatic ischemia/reperfusion (I/R) injury in a rat model, and to investigate the effects on HBO₂P and I/R injury of blocking HSP70 using antibody (Ab) pretreatment. MATERIAL AND METHODS Male Sprague-Dawley rats underwent HBO₂P for 60 min at 2.0 atmosphere absolute (ATA) pressure for five consecutive days before surgical hepatic I/R injury, performed by clamping the portal vein and hepatic lobe...
November 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30416194/long-noncoding-rna-fezf1-as1-promotes-proliferation-and-inhibits-apoptosis-in-ovarian-cancer-by-activation-of-jak-stat3-pathway
#17
Xia Zhao, Zhaofang Cheng, Jian Wang
BACKGROUND Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in human cancers, including ovarian cancer. Several reports identified lncRNA FEZF1-AS1 as an oncogene in gastric cancer, colorectal carcinoma, and non-small cell lung cancer (NSCLC). However, the function of FEZF1-AS1 in ovarian cancer remains largely unknown. This study was aimed to investigate the role of FEZF1-AS1 in ovarian cancer. MATERIAL AND METHODS FEZF1-AS1 expression levels in pairs of ovarian cancer tissues and adjacent normal tissues were measured by quantitative real-time polymerase chain reaction (qRT-PCR)...
November 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30415269/ic-2-suppresses-proliferation-and-induces-apoptosis-of-bladder-cancer-cells-via-the-wnt-%C3%AE-catenin-pathway
#18
Lingfeng Wu, Shunliang He, Yi He, Xueping Wang, Linfeng Lu
BACKGROUND The Wnt/β-catenin signaling pathway participates in many important tumorigeneses processes, including bladder cancer. The inhibition of abnormal activation of Wnt pathways might provide a new approach to tumor treatment. In the present study, we investigated the role of IC-2, a novel Wnt pathways small molecular inhibitor, in bladder cancer tumorigenesis. MATERIAL AND METHODS Bladder cancer cells were treated with various concentrations of IC-2 (0-5 μM) in vitro. The proliferation ability was measured using colony formation assay and apoptosis was measured using flow cytometry analysis...
November 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30415268/a-propensity-score-matched-analysis-for-non-intubated-thoracic-surgery
#19
Lan Lan, Yanyi Cen, Canzhou Zhang, Yuan Qiu, Baoyi Ouyang
BACKGROUND Most observations of non-intubated anesthesia under spontaneous breathing are small-cohort, non-homogeneous surgery types and lack an intubation control. We therefore retrospectively compared the perioperative conditions and postoperative recovery of non-intubated video-assisted thoracoscopic surgery (NIVATS group) and intubated VATS (IVATS group) with a propensity score-matching analysis. MATERIAL AND METHODS We case-matched 119 patients in the NIVATS group with patients in the IVATS group by a propensity score-matched analysis...
November 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30415267/silencing-the-folr2-gene-inhibits-cell-proliferation-and-increases-apoptosis-in-the-nci-h1650-non-small-cell-lung-cancer-cell-line-via-inhibition-of-akt-mammalian-target-of-rapamycin-mtor-ribosomal-protein-s6-kinase-1-s6k1-signaling
#20
Xiaohua Xu, Jianyang Jiang, Lijuan Yao, Bing Ji
BACKGROUND The FOLR2 gene encodes folate receptor-beta (FR-beta), which is expressed by tumor-associated macrophages. The effects of FOLR2 gene expression in non-small cell lung cancer (NSCLC) remains unknown. This study aimed to investigate the effects of FOLR2 gene expression and gene silencing in human NSCLC cell lines and normal human bronchial epithelial (HBE) cells in vitro. MATERIAL AND METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to detect the expression of the FOLR2 gene, cell cycle and apoptosis-associated genes in normal HBE cells and the NSCLC cell lines, A549, NCI-H1299, NCI-H1650, and NCI-H460...
November 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
journal
journal
32555
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"