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Medical Science Monitor: International Medical Journal of Experimental and Clinical Research

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https://www.readbyqxmd.com/read/30007063/two-plane-assessment-of-knee-muscles-isometric-and-isokinetic-torques-after-anterior-cruciate-ligament-reconstruction
#1
Andrzej Czamara, Aleksandra Królikowska
BACKGROUND We tested the hypothesis that, in patients participating in 17 weeks of postoperative physiotherapy after anterior cruciate ligament reconstruction (ACLR), maximal isometric torque (IT) and peak torque (PT) generated by the muscles affecting the operated knee joint in the sagittal and transverse planes are not restored. We also present the application of IT and PT measurements of the muscles affecting the knee joint in 2 planes of motion. MATERIAL AND METHODS IT and PT of the knee extensor and flexor muscles and the muscles internally rotating the shin were measured in 30 males who participated in postoperative physiotherapy for 17 weeks after ACLR (ACLR group) and 30 males with no injuries (control group)...
July 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30006997/quantifying-the-stiffness-of-achilles-tendon-intra-and-inter-operator-reliability-and-the-effect-of-ankle-joint-motion
#2
Chun Long Liu, Ya Peng Li, Xue Qiang Wang, Zhi Jie Zhang
BACKGROUND The objectives of the present study were to examine the intra- and inter-operator reliability of the MyotonPRO device in quantifying the stiffness of the Achilles tendon and the device's ability to examine the modulation in stiffness of the Achilles tendon during ankle joint flexion. MATERIAL AND METHODS Twenty asymptomatic participants (10 males and 10 females; mean age: 25.0±3.1 years) were recruited for this study. The stiffness of the Achilles tendon was quantified using the MyotonPRO device...
July 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30006502/protective-effect-of-dexmedetomidine-on-endotoxin-induced-acute-lung-injury-in-rats
#3
Peng Z Meng, Jing Liu, Ping S Hu, Fei Tong
BACKGROUND The purpose of this study was to investigate whether DEX exerts protective mechanisms in rats with acute lung injury (ALI) induced by the endotoxin lipopolysaccharide (LPS). The mortality rate of ALI is extremely high. DEX, an a2 adrenergic receptor agonist, has potent anti-inflammatory and organ-protective effects in addition to its sedative and analgesic properties. We sought to elucidate whether DEX can attenuate acute lung injury. MATERIAL AND METHODS Forty-eight Wister rats were randomly divided into 4 groups (n=12, per group): the normal saline control (NS) group, receiving tail-vein injection of 0...
July 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30005060/lysophosphatidic-acid-promotes-expression-and-activation-of-matrix-metalloproteinase-9-mmp9-in-thp-1-cells-via-toll-like-receptor-4-nuclear-factor-%C3%AE%C2%BAb-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#4
Zhi-Bin Zhou, Bo Yang, Xiaohao Li, Hao Liu, Gang Lei
BACKGROUND Lysophosphatidic acid (LPA) is an active compound of oxidized low-density lipoprotein that serves as an endogenous TLR4 ligand. Ligand activation of TLR4 activates nuclear factor-kappaB (NF-κB) and the transcription of NF-κB-regulated inflammatory cytokines, which are involved in the development of atherosclerosis. MMP9 is a member of the MMP family and can affect plaque stability. However, the mechanism responsible for the effect of LPA on the expression and activation of MMP9 has not been fully elucidated...
July 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30004089/klotho-inhibits-proliferation-and-migration-of-angiotensin-ii-induced-vascular-smooth-muscle-cells-vsmcs-by-modulating-nf-%C3%AE%C2%BAb-p65-akt-and-extracellular-signal-regulated-kinase-erk-signaling-activities
#5
Shasha Yu, Yintao Chen, Shuang Chen, Ning Ye, Yan Li, Yingxian Sun
BACKGROUND It has been proven that phenotype shifting, from the contractile phenotype to the synthetic phenotype, of vascular smooth muscle cells (VSMCs), plays an important role in vascular diseases such as atherosclerosis, restenosis, and hypertension. Recently, accumulating evidence suggests that Klotho is associated with many cardiovascular diseases or damage. Through the estimation of the proliferation and migration of Ang II-induced VSMCs and the related intracellular signal transduction pathways, we researched the effects of Klotho on phenotype modulation in this study...
July 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30002361/overexpression-of-dna-cytosine-5-methyltransferase-1-dnmt1-and-dna-cytosine-5-methyltransferase-3a-dnmt3a-is-associated-with-aggressive-behavior-and-hypermethylation-of-tumor-suppressor-genes-in-human-pituitary-adenomas
#6
Hou-Shi Ma, Elaine Lu Wang, Wen-Fei Xu, Shozo Yamada, Katsuhiko Yoshimoto, Zhi Rong Qian, Long Shi, Li-Li Liu, Xu-Hui Li
BACKGROUND Alteration of DNA methylation of tumor suppressor genes (TSGs) is one of the most consistent epigenetic changes in human cancers. DNMTs play several important roles in DNA methylation and development of cancers. Regarding DNMTs protein expressions, little is known about the clinical significance and correlation with promoter methylation status of TSGs in human pituitary adenomas. MATERIAL AND METHODS We analyzed the protein expression of 3 DNMTs using immunohistochemistry and assessed DNA hypermethylation of RASSF1A, CDH13, CDH1, and CDKN2A (p16) in 63 pituitary adenomas...
July 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30001299/partial-recovery-of-limb-function-following-end-to-side-screw-anastomosis-of-phrenic-nerve-in-rats-with-brachial-plexus-injury
#7
Guang-Liang Hao, Tian-Yin Zhang, Qiang Zhang, Ming-Yong Gu, Chen Chen, Lin Zou, Xue-Cheng Cao, Gui-Chun Zhang
BACKGROUND Brachial plexus injury (BPI), a severe nervous system injury, is a leading cause of functional damages of the affected upper limb. Patients with BPI manifested with motor weakness or paralysis, sensory deficits, and pain. We established a BPI rat model to explore the in vivo effect of end-to-side screw anastomosis (ETSSA) of phrenic nerve on the recovery of limb function after BPI. MATERIAL AND METHODS After modeling, rats were treated with end-to-side anastomosis (ETSA) and ETSSA respectively. After 1 and 3 months, the behavioral changes of rats were observed using the Terzis grooming test, and the compound muscle action potential (CMAP) and muscle tension of biceps brachii were detected...
July 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29999001/genistein-and-myd88-activate-autophagy-in-high-glucose-induced-renal-podocytes-in-vitro
#8
Yuanyuan Wang, Ying Li, Tao Zhang, Yanqing Chi, Maodong Liu, Ying Liu
BACKGROUND Renal podocyte damage plays a crucial role in the development of diabetic nephropathy. Genistein is derived from a leguminous plant, and MyD88 and TRIF are adaptor molecules in the Toll-like receptor (TLR) signaling pathway, which may play a role in autophagy. In this study, we utilized an in vitro high glucose (HG)-treated podocyte model to investigate the effects and underlying mechanisms of Genistein and MyD88 or TRIF siRNA induced autophagy and renal protection. MATERIAL AND METHODS An immortalized mouse podocyte cell line was treated with HG, Genistein, chloroquine, and/or transfected with specific Myd88 and TRIF siRNAs...
July 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29997385/expression-of-microrna-99a-3p-in-prostate-cancer-based-on-bioinformatics-data-and-meta-analysis-of-a-literature-review-of-965-cases
#9
Hai-Biao Yan, Yu Zhang, Jie-Mei Cen, Xiao Wang, Bin-Liang Gan, Jia-Cheng Huang, Jia-Yi Li, Qian-Hui Song, Sheng-Hua Li, Gang Chen
BACKGROUND microRNAs (miRNAs) have a role as biomarkers in human cancer. The aim of this study was to use bioinformatics data, and review of cases identified from the literature, to investigate the role of microRNA-99a-3p (miR-99a-3p) in prostate cancer, including the identification of its target genes and signaling pathways. MATERIAL AND METHODS Meta-analysis from a literature review included 965 cases of prostate cancer. Bioinformatics databases interrogated for miR-99a-3p in prostate cancer included The Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO), and ArrayExpress...
July 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29995830/endotoxin-tolerant-dendritic-cells-suppress-inflammatory-responses-in-splenocytes-via-interleukin-1-receptor-associated-kinase-irak-m-and-programmed-death-ligand-1-pdl-1
#10
Yuping Zhou, Qin Xia, Xi Wang, Shukun Fu
BACKGROUND Sepsis causes the highest mortality in non-cardiovascular intensive care units worldwide. Recent research has demonstrated that the late phase of sepsis, characterized as septic immunosuppression, is the central pathophysiological mechanism of immune dysfunction. Investigating the suppressive mechanism of immune cells may identify possible targets for therapy. MATERIAL AND METHODS We used LPS 2-hit model for dendritic cells (DCs) to establish endotoxin tolerance, and co-cultured with splenocytes...
July 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29992917/comparison-of-esophageal-function-tests-to-investigate-the-effect-of-helicobacter-pylori-infection-on-gastroesophageal-reflux-disease-gerd
#11
Lan Liu, Hongwei Gao, Hongjuan Wang, Weihua Yu, Kongxi Zhu, Yuan Zhang, Jianqiang Guo
BACKGROUND The effects of Helicobacter pylori (H. pylori) infection on gastroesophageal reflux disease (GERD) remain unclear. The aim of this study was to compare the results of clinical esophageal function tests and the effect of H. pylori infection on GERD. MATERIAL AND METHODS A prospective clinical study included 124 patients diagnosed with GERD (four grades). H. pylori infection was determined by gastroscopy and a rapid urease test (RUT) to divide patients into an HP-positive and an HP-negative group. Esophageal function tests included high-resolution manometry (HRM), peristalsis break (PB), and 24-hour pH monitoring (composite pH DeMeester score)...
July 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29991674/keratin-17-promotes-lung-adenocarcinoma-progression-by-enhancing-cell-proliferation-and-invasion
#12
Jianbo Liu, Lei Liu, Lina Cao, Qiang Wen
BACKGROUND Lung adenocarcinoma (LAC) accounts for the majority of lung cancer, which is the leading cause of cancer-related mortality worldwide. Keratin 17 (KRT17) was reported to promote the tumor development of skin tumor and oral cancer. The aim of this study was to investigate the expression and function of KRT17 in LAC. MATERIAL AND METHODS Immunohistochemical staining and quantitative PCR were performed to explore the expression of KRT17 in both LAC tissues and adjacent normal liver tissues. Chi-square test, univariate analysis, and multivariate analysis were conducted to statistically evaluate the clinical significance of KRT17 in LAC...
July 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29990315/overexpression-of-rho-associated-coiled-coil-containing-protein-kinase-2-is-correlated-with-clinical-progression-and-poor-prognosis-in-breast-cancer
#13
Hua Yi, Kun Wang, He Jin, Junfang Su, Yidan Zou, Qiao Li, Lina He, Xiaodong Liu, Biaoyan Du
BACKGROUND Rho-associated coiled-coil containing protein kinases 2 (ROCK2) is one of the best characterized targets for the small GTPase Rho. It has been reported that ROCK2 is critical for cancer cell migration and invasion. The objective of this study was to investigate the association of ROCK2 expression with clinicopathological features and overall survival of breast cancer patients. MATERIAL AND METHODS The expression of ROCK2 in breast cancer and paired adjacent normal tissues was detected and compared by immunohistochemical staining of tissue array...
July 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29988027/increased-expression-of-the-ypel3-gene-in-human-colonic-adenocarcinoma-tissue-and-the-effects-on-proliferation-migration-and-invasion-of-colonic-adenocarcinoma-cells-in-vitro-via-the-wnt-b-catenin-signaling-pathway
#14
Xianyi Kong, Yong Li, Xiaolei Zhang
BACKGROUND The aim of this study was to investigate the effects of the expression of the YPEL3 gene in colonic adenocarcinoma cells grown in vitro and in colonic adenocarcinoma tissue from patients treated by surgical resection. MATERIAL AND METHODS The study included 108 patients diagnosed with primary colon cancer (Stages I to IV). The expression of the YPEL3 gene in colonic adenocarcinoma tissue and adjacent normal colonic tissue was detected by real-time quantitative PCR (qRT-PCR). The normal human colonic cell line CCD-1Co and colorectal adenocarcinoma cell lines HT-29 and HCT-8 were induced to overexpress the YPEL3 gene, and the effects on cell proliferation, migration, and invasion of colonic adenocarcinoma cells were investigated by the Cell Counting Kit-8 (CCK-8) assay, a transwell migration assay, and a transwell invasion assay, respectively...
July 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29987270/quercetin-treatment-improves-renal-function-and-protects-the-kidney-in-a-rat-model-of-adenine-induced-chronic-kidney-disease
#15
Hu Yang, Yan Song, Ya-Nan Liang, Rong Li
BACKGROUND The aim of this study was to examine the effects of the natural flavonoid, quercetin, in a rat model of adenine-induced chronic kidney disease. MATERIAL AND METHODS Forty male Wister rats were divided into four groups: normal (no adenine or quercetin) (n=10); untreated model (treated withadenine but not quercetin) (n=10); quercetin-treated model (5 mg/kg/day for 21 days) (n=10); quercetin-treated model (10 mg/kg/day for 21 days) (n=10). Urine and blood samples were collected and rat kidneys were examined histologically...
July 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29986343/risk-factors-of-cage-subsidence-in-patients-with-ossification-of-posterior-longitudinal-ligament-opll-after-anterior-cervical-discectomy-and-fusion
#16
Baoyang Zhang, Shaoqing Li, Dechao Miao, Chong Zhao, Linfeng Wang
BACKGROUND There are numerous reports on cage subsidence after ACDF; however, few studies have identified its risk factors. The current study aimed to identify risk factors for cage subsidence after ACDF using the PEEK cage packed with local autobone implant with plate and provides evidence for surgical decision-making. MATERIAL AND METHODS We retrospectively reviewed 77 patients with OPLL who underwent 1/2-level ACDF using the PEEK cage packed with local autobone implant with plate from March 2013 to December 2015...
July 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29985910/does-timing-of-surgery-affect-treatment-of-the-terrible-triad-of-the-elbow
#17
Chengwei Zhou, Jinti Lin, Jianxiang Xu, Renjin Lin, Kai Chen, Shuaibo Sun, Jianzhong Kong, Xiaolong Shui
BACKGROUND This study investigated the influence of surgical timing on the treatment of terrible triad of the elbow (TTE). MATERIAL AND METHODS After exclusion, 63 patients were enrolled in this study: 20 patients were classified into the emergency group (group A, within 24 h after injury), 26 into the early surgery group (group B, from 4 to 14 days after injury), and 17 into the delayed surgery group (group C, more than 14 days after injury). All patients underwent the same approach, and elbow motion and complication rates were recorded and compared...
July 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29984790/correlation-of-macc1-c-myc-expression-in-endometrial-carcinoma-with-clinical-pathological-features-or-prognosis
#18
Qinghua Zhang, Ping Xu, Yanxia Lu, Hongtao Dou
BACKGROUND Endometrial carcinoma (EC) is a type of female reproductive malignant tumor, the incidence of which is generally 20~30%. Multiple factors and genes are involved in the regulation of EC occurrence and progression. This study aimed to measure the expressions of MACC1 and c-Myc in EC patients to analyze their correlation with pathological features of EC. MATERIAL AND METHODS A total of 60 EC patients were recruited in the experimental group, while another cohort of 30 people with endometrial inflammatory hyperplasia was enrolled in the control group...
July 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29983409/origin-and-efficacy-of-hyaluronan-injections-in-knee-osteoarthritis-randomized-double-blind-trial
#19
Yuanli Guo, Peiyan Yang, Liu Liu
BACKGROUND Several hyaluronan preparations are available that have different dosage forms, origins, and concentrations. The objective of the study was to compare the efficacy of intra-articular chemically cross-linked hyaluronan (CCH) and avian-derived hyaluronan (ADH) injections in knee osteoarthritis (KOA) patients. MATERIAL AND METHODS In total, 258 patients were randomized into 2 groups of 129 each: patients who received CCH injection (CCH group) and patients who received ADH injection (ADH group). Radiographic Kellgren-Lawrence score, visual analog scale (VAS) pain score, Lequesne index score, the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, single-limb stance (SLS) test, and timed "Up-and-Go" (TUG) test were performed...
July 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29982265/pre-pregnancy-health-status-and-risk-of-preterm-birth-a-large-chinese-rural-population-based-study
#20
Cheng-Yang Hu, Feng-Li Li, Wen Jiang, Xiao-Guo Hua, Xiu-Jun Zhang
The aim of this study was to estimate the incidence of preterm birth (PTB) and identify maternal risk factors before pregnancy in rural China, and to determine their population-attributable fractions (PAFs). A prospectively population-based study was conducted in the city of Fuyang, China. Surveillance locations were randomly selected by cluster sampling based on administrative areas and geographic characteristics. Data were collected through interview questionnaires and medical examination records from the participants, then follow-up until discharge, fetus death, or at a maximum of 6 weeks postpartum, whichever came first...
July 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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