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Medical Science Monitor: International Medical Journal of Experimental and Clinical Research

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https://www.readbyqxmd.com/read/30227444/diagnostic-and-outcome-prediction-value-of-transthoracic-impedance-cardiography-in-heart-failure-patients-during-heart-failure-flare-ups
#1
Saulius Sadauskas, Albinas Naudžiūnas, Alvydas Unikauskas, Edita Mašanauskienė, Andrius Ališauskas, Giedrė Bakšytė, Andrius Macas
BACKGROUND This study aimed at evaluating the diagnostic and outcome prediction value of transthoracic impedance cardiography (ICG) in heart failure (HF) patients admitted for in-hospital treatment due to flare-ups of their condition. MATERIAL AND METHODS In total, 120 patients of intensive care units who were admitted due to HF flare-ups were involved to the study. The findings of ICG were compared to data obtained by other methods used for diagnosing HF. RESULTS Statistically significant (p<0.001) results were obtained when evaluating differences in ICG data between admission and discharge from the intensive care unit...
September 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30226834/tetrahydropalmatine-prevents-high-fat-diet-induced-hyperlipidemia-in-golden-hamsters-mesocricetus-auratus
#2
Caihua Sun, Zhiyun Chen, Hui Wang, Ke Ding
BACKGROUND Hyperlipidemia is a major cause of atherosclerotic cardiovascular disease. Tetrahydropalmatine (THP) can exhibit hepatoprotective, anti-arrhythmic, and anti-inflammatory activities. The mechanism of THP on the hyperlipidemia remains unknown; therefore, the present study explored the role of THP in hyperlipidemia. MATERIAL AND METHODS We established an animal model of hyperlipidemia by high-fat diet (HFD) feeding. Blood samples were obtained for determination of serum cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), pro-inflammatory cytokines, and CYP7A1 expression...
September 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30226219/natural-transmission-of-b2-b3-subdeletion-or-duplication-to-expanded-y-chromosome-microdeletions
#3
Yuan Pan, Lei-Lei Li, Yang Yu, Yu-Ting Jiang, Xiao Yang, Hong-Guo Zhang, Rui-Zhi Liu, Rui-Xue Wang
BACKGROUND Y chromosome microdeletions are usually de novo mutations, but in several cases, transmission from fertile fathers to infertile sons has been reported. MATERIAL AND METHODS We report 3 cases of infertile patients who inherited expanded Y chromosome microdeletions from their fathers, who carried b2/b3 subdeletion or duplication. The karyotype was analyzed using G-banding. High-throughput sequencing was used to detect AZF region microdeletions. RESULTS Cytogenetic analysis showed a normal karyotype 46,XY in patient 1 (P1), patient 2 (P2), and their fathers (F1 and F2)...
September 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30224626/anticancer-activity-of-phloretin-against-human-gastric-cancer-cell-lines-involves-apoptosis-cell-cycle-arrest-and-inhibition-of-cell-invasion-and-jnk-signalling-pathway
#4
Min Xu, Weiguang Gu, Zhou Shen, Fang Wang
BACKGROUND Gastric cancer is one of most commonly diagnosed cancers and causes significant mortality worldwide. In this study, the antiproliferative and anticancer effects of Phloretin were evaluated against gastric cancer cell lines. MATERIAL AND METHODS MTT assay was used to assess the proliferation rate of gastric cancer cells. DAPI and annexin V/PI were used for detection of apoptotic cell death. Cell invasion was investigated by Transwell assays and the expression of the proteins was estimated by immunoblotting...
September 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30223281/effect-of-different-methods-of-administration-of-diltiazem-on-clinical-efficacy-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#5
Lanfang Zhang, Xiaoyong Qi, Xinwei Jia
BACKGROUND The aim of this study was to investigate the optimal route of administration of diltiazem in emergency PCI and to provide the best clinical treatment for ASTEMI patients. MATERIAL AND METHODS A total of 90 patients with ASTEMI treated in our hospital from January 2015 to January 2016 were selected. Prior to thrombus aspiration, a thrombus aspiration catheter was used to perform diltiazem injection at the distal end of the infarct-related artery (IRA). We chose the acute ST-elevation myocardial infarction (ASTEMI) patients treated with direct PCI to compare different administration routes of diltiazem...
September 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30222727/extreme-learning-machine-elm-based-classification-of-benign-and-malignant-cells-in-breast-cancer
#6
Abdullah Toprak
BACKGROUND Breast cancer is one of the most common cancer types in the world and is a serious threat to health. This type of cancer is complex; it is a hereditary disease and does not result from a single cause. The diagnosis of cancer starts with a biopsy. Various methods are used to detect and recognize cancer cells, from microscopic images and mammography to ultrasonography and magnetic resonance images (MRI). MATERIAL AND METHODS Detection and characterization of benign and malignant cells by image-processing-based segmentation for breast cancer diagnosis is important for early diagnosis...
September 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30221634/strontium-ranelate-combined-with-insulin-is-as-beneficial-as-insulin-alone-in-treatment-of-fracture-healing-in-ovariectomized-diabetic-rats
#7
Guo-Long Cao, Fa-Ming Tian, Guang-Yuan Liu, Hui-Ping Song, Lei-Liang Yuan, Lin-Dan Geng, Ming-Jian Bei, Zhi-Yuan Zheng, Liu Zhang
BACKGROUND Type 2 diabetes mellitus (T2DM) and estrogen deficiency both predispose fracture patients to increased risk of delayed union or nonunion. The present study investigated the effects of strontium ranelate (SR) on fracture healing in ovariectomized (OVX) diabetic rats. MATERIAL AND METHODS A mid-shaft fracture was established in female normal control (CF), diabetic (DF), and OVX diabetic (DOF) rats. Treated DOF rats received either insulin alone (DOFI) or combined with SR (DOFIS). All rats were euthanized at 2 or 3 weeks after fracture...
September 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30220702/effect-of-phacoemulsification-on-visual-acuity-and-macular-morphology-in-patients-with-wet-age-related-macular-degeneration
#8
Małgorzata Figurska, Agnieszka Bogdan-Bandurska, Marek Rękas
BACKGROUND This article discusses the effectiveness of phacoemulsification cataract surgery with intraocular lens implantation in patients with wet age-related macular degeneration in the inactive phase of the disease. MATERIAL AND METHODS Forty-nine patients (50 eyes) aged 78.94±5.54 years, previously treated with intravitreal injections of anti-vascular endothelial growth factor agents, were qualified for a prospective, randomized 12-month study. The participants were divided into 2 groups. Group I consisted of 25 patients (25 eyes) who were subjected to phacoemulsification cataract surgery...
September 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30219821/identification-of-the-risk-hla-a-alleles-and-autoantigen-in-han-chinese-vitiligo-patients-and-the-association-of-cd8-t-cell-reactivity-with-disease-characteristics
#9
Xiuli Yi, Tingting Cui, Shuli Li, Yuqi Yang, Jiaxi Chen, Sen Guo, Zhe Jian, Chunying Li, Tianwen Gao, Ling Liu, Kai Li
BACKGROUND Multiple studies have implicated a role for CD8+T cell-mediated immune response to autoantigens in vitiligo. However, the antigen-specific T lymphocyte reactivity against the peptide epitopes is diverse among different world populations. This study aimed to identify the risk HLA-A allele in vitiligo and study CD8+ T cell reactivity to 5 autoantigenic peptides in Han Chinese populations, and to analyze the association of CD8+ T cell reactivity with disease characteristics. MATERIAL AND METHODS The risk HLA-A allele was analyzed by case-control study...
September 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30219820/clinical-features-of-167-inpatients-with-autosomal-dominant-polycystic-kidney-disease-at-a-single-center-in-china
#10
Jialin Meng, Yuchen Xu, Ao Li, Song Fan, Xufeng Shen, Dongyue Ma, Li Zhang, Zongyao Hao, Xiansheng Zhang, Chaozhao Liang
BACKGROUND The aim of this study was to describe the clinical characteristics of Chinese ADPKD inpatients and to identify the factors associated with disease severity. MATERIAL AND METHODS We included 167 hospitalized patients (inpatients) with ADPKD in this study. Multiple regression analyses were conducted to determine factors correlated with estimated glomerular filtration rate (eGFR). Patients were stratified into subgroups according to the presence of symptoms, in which clinical parameters were analyzed and compared...
September 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30219819/microrna-7-5p-promotes-cisplatin-resistance-of-cervical-cancer-cells-and-modulation-of-cellular-energy-homeostasis-by-regulating-the-expression-of-the-parp-1-and-bcl2-genes
#11
Fengxia Yang, Li Guo, Yujing Cao, Shizhen Li, Jianhua Li, Min Liu
BACKGROUND Resistance to cisplatin results in recurrence or relapse of cervical cancer in women. An understanding of the mechanisms of cisplatin resistance will be important to improve the efficacy of cisplatin treatment. The aim of this study was to investigate the role of microRNA-7-5p (mir-7-5p) in cisplatin-resistant cervical cancer cells in vitro. MATERIAL AND METHODS The expression levels of miR-7-5p were detected in cisplatin-resistant cervical cancer cells, HeLa, and SiHa cells (HPV16-positive), and in clinical tissue samples, using miR-7-5p inhibition and a luciferase reporter assay...
September 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30218608/n-methyl-pyrrolidone-nmp-alleviates-lipopolysaccharide-lps-induced-inflammatory-injury-in-articular-chondrocytes
#12
Xianping Zhu, Lin Wang, Xiao Teng, Qi Chen, Chenshuai Pan
BACKGROUND Studies on the chondrocyte inflammatory injury are very important for understanding the pathogenesis and clinical treatment of osteoarthritis (OA). Evidence suggests that N-methyl pyrrolidone (NMP) may be used as an adjuvant therapy alongside established methods of OA treatment. This study investigated the effect of NMP on chondrocyte inflammatory injury and explored the underlying molecular mechanism. MATERIAL AND METHODS To mimic the inflammatory injury in vitro, the articular chondrocyte line ATDC5 was simulated with lipopolysaccharide (LPS)...
September 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30218532/factors-associated-with-caregiver-burden-in-primary-caregivers-of-patients-with-adolescent-scoliosis-a-descriptive-cross-sectional-study
#13
Cuicui Li, Jinlin Miao, Xi Gao, Linhong Zheng, Xiangni Su, Hui Hui, Jing Hu
BACKGROUND Primary caregivers for patients with scoliosis suffer from considerable distress and burden. However, a few studies have examined the factors related to burden of caregivers of patients with adolescent scoliosis, particularly in China. Therefore, the present study aimed to identify patient and caregiver characteristics associated with caregiver burden. MATERIAL AND METHODS A cross-sectional study was conducted in a sample comprising 87 pairs of patients with adolescent scoliosis and their primary caregivers from July 2014 to October 2016 in Xi'an, China...
September 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30217969/comparison-of-thrombelastography-teg-in-patients-with-acute-cerebral-hemorrhage-and-cerebral-infarction
#14
Zongbao Liu, Erqing Chai, Hecheng Chen, Hongzhi Huo, Fei Tian
BACKGROUND The aim of this study was to analyze the changing role of thrombelastography (TEG) by detecting the indexes of TEG in patients with acute cerebral hemorrhage and cerebral infarction, combined with pathogenesis, and to find objective laboratory indexes for the diagnosis and treatment of cerebrovascular diseases. MATERIAL AND METHODS Data from 150 patients were collected, including 69 cases identified as the cerebral infarction group and 81 cases identified as the cerebral hemorrhage group. In addition, 50 healthy adults were selected as a control group...
September 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30216335/time-course-investigation-of-intervertebral-disc-degeneration-induced-by-different-sizes-of-needle-punctures-in-rat-tail-disc
#15
Tao Chen, Xiaofei Cheng, Jingcheng Wang, Xinmin Feng, Liang Zhang
BACKGROUND This study aimed to determine the best size needle to use in inducing IVDD and to find the proper time point of disc degeneration suitable for further biologic treatment study. MATERIAL AND METHODS First, rat tail level 5/6, 7/8, and 9/10 discs were punctured by 18G, 21G, or 25G needles. Then, degeneration was assessed by radiography, MRI, and histological evaluation at 2, 4, and 6 weeks after puncture. Later, real-time reverse transcriptase (RT-PCR) was used to examine mRNA expressions of aggrecan, collagen type II, hypoxia-inducible factor-1a (HIF-1a), glucose transporter1 (GLUT-1), and vascular endothelial growth factor (VEGF)...
September 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30215387/one-pot-facile-fabrication-of-bioavailable-iron-nanoparticles-with-good-biocompatibility-for-anemia-therapy
#16
Yuling Gu, Yunlong Li, Yuan Yang, Qi Luo, Ying Zhang, Chenmin Zhou
BACKGROUND Iron deficiency anemia (IDA) has been a major public health problem all over the world. Developing new iron (Fe) fortificants with both high bioavailability and negligible food sensory changes for IDA is in urgent demand. MATERIAL AND METHODS The Fe nanoparticles were fabricated through a one-pot reduction process under the protection of bovine serum albumin (BSA). The BSA-Fe nanoparticles were characterized systematically. The comparisons between BSA-Fe nanoparticles and FeSO4 in bioavailability were carried out through hemoglobin (Hb) repletion method...
September 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30213925/identification-of-key-pathways-and-genes-in-anaplastic-thyroid-carcinoma-via-integrated-bioinformatics-analysis
#17
Shengqing Hu, Yunfei Liao, Lulu Chen
BACKGROUND To provide a better understanding of anaplastic thyroid carcinoma (ATC) at the molecular level, this study aimed to identify the genes and key pathways associated with ATC by using integrated bioinformatics analysis. MATERIAL AND METHODS Based on the microarray data GSE9115, GSE65144, and GSE53072 derived from the Gene Expression Omnibus, the differentially expressed genes (DEGs) between ATC samples and normal controls were identified. With DEGs, we performed a series of functional enrichment analyses...
September 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30212440/plasma-resistin-levels-in-patients-with-acute-aortic-dissection-a-propensity-score-matched-observational-case-control-study
#18
Xintian Liu, Xuan Zheng, Xi Su, Wei Tian, Yuanping Hu, Zhiping Zhang
BACKGROUND The aim of this observational case-control study was to compare the levels of plasma resistin between patients with acute aortic dissection and matched controls, and to use propensity score matching (PSM) to reduce case selection bias and clinical confounders. MATERIAL AND METHODS With the use of PSM, this study included 43 pairs of patients with acute aortic dissection (type-A and type-B dissection) and matched controls. Plasma resistin levels and other laboratory parameters were compared between the two groups, including white blood cell (WBC) count, glucose, high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and D-dimer...
September 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30210141/melatonin-upregulates-nuclear-factor-erythroid-2-related-factor-2-nrf2-and-mediates-mitophagy-to-protect-against-early-brain-injury-after-subarachnoid-hemorrhage
#19
Bin Sun, Song Yang, Shengli Li, Chunhua Hang
BACKGROUND The aim of this study was to investigate whether melatonin is involved in brain injury following subarachnoid hemorrhage (SAH). MATERIAL AND METHODS An SAH model was established and TUNEL assays were utilized to detect the effect of melatonin on cell apoptosis. Western blot analysis was used to detect the effect of melatonin on expression of autophagic markers and apoptotic factors. Real-time PCR, Western blot analysis, and luciferase assay were performed to study the effect of melatonin on nuclear factor erythroid-2 related factor 2 (NRF2) expression...
September 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30209248/clinicopathological-and-prognostic-significance-of-expression-of-b-cell-specific-moloney-murine-leukemia-virus-insertion-site-1-bmi-1-gene-and-protein-in-gastrointestinal-stromal-tumors
#20
Kun Zhu, Kang Li, Da-Wei Yuan, Gang Xu, Li Kang, Cheng-Xue Dang, Yong Zhang
BACKGROUND Gastrointestinal stromal tumor (GIST) is an uncommon visceral sarcoma that arises predominantly in the gastrointestinal tract. Since GISTs are encountered infrequently and inflexible to traditional therapy, the aim of the present study was to explore the correlation of B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI-1) mRNA and BMI-1 protein levels with the clinicopathological characteristics and prognosis significance of GISTs. MATERIAL AND METHODS GIST tissues and normal tissues were collected from 156 patients who had undergone surgical treatment...
September 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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