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Journal of Investigative Dermatology. Symposium Proceedings

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https://www.readbyqxmd.com/read/28941500/prostaglandin-d2-uses-components-of-ros-signaling-to-enhance-testosterone-production-in-keratinocytes
#1
Alon Mantel, J Tyson McDonald, Kennedy Goldsborough, Valerie M Harvey, Joanne Chan
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941499/genomic-investigation-of-lupus-in-the-skin
#2
REVIEW
Animesh A Sinha, Rama Dey-Rao
Lupus erythematosus is a chronic autoimmune disorder with a protean clinical manifestation affecting virtually every organ including skin, with tremendous variation between patients. This makes it vital to stratify patients on a molecular basis. We used gene microarray technology for large-scale screening combined with bioinformatics to investigate global patterns of gene expression in cutaneous lupus erythematosus to allow further insights into disease heterogeneity. Unbiased clustering exposed a clear separation between cutaneous lupus erythematosus skin and blood samples...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941498/not-just-skin-deep-systemic-disease-involvement-in-patients-with-cutaneous%C3%A2-lupus
#3
REVIEW
Jack C O'Brien, Benjamin F Chong
Cutaneous lupus erythematosus, specifically discoid lupus erythematosus, disproportionately affects those with skin of color and may result in greater dyspigmentation and scarring in darker skin types. In this article, we review investigations relevant to cutaneous lupus patients with skin of color at University of Texas Southwestern Medical Center, associations and risk of progression to systemic lupus, and recommendations for monitoring for systemic disease spread. Between 5% and 25% of patients with cutaneous lupus can develop systemic lupus...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941497/cutaneous-lupus-a-brief-review-of-old-and-new-medical-therapeutic-options
#4
REVIEW
Fnu Nutan, Alex G Ortega-Loayza
Systemic lupus erythematosus is a chronic inflammatory condition which affects predominantly women in their 30s. It has several clinical manifestations, including skin lesions that can be classified as acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus. A multifaceted approach to treating cutaneous lupus is advocated.
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941496/quinacrine-suppresses-tumor-necrosis-factor-%C3%AE-and-ifn-%C3%AE-in-dermatomyositis-and%C3%A2-cutaneous-lupus-erythematosus
#5
REVIEW
Paul Alves, Muhammad M Bashir, Maria Wysocka, Majid Zeidi, Rui Feng, Victoria P Werth
Antimalarials are used to treat dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) has shown additional clinical effects when combined with HCQ. To quantify the effects of HCQ versus QC in suppressing secretion of tumor necrosis factor-α (TNF-α) and IFN-α from the peripheral blood mononuclear cells of DM and CLE patients, lipopolysaccharide-stimulated and control peripheral blood mononuclear cells from DM and CLE patients and control subjects were analyzed for the effect of HCQ and QC on TNF-α and IFN-α production using ELISA testing...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941495/central-centrifugal-cicatricial-alopecia-new-insights-and-a-call-for-action
#6
REVIEW
Ncoza C Dlova, Kimberly S Salkey, Valerie D Callender, Amy J McMichael
Central centrifugal cicatricial alopecia (CCCA) is a common and progressive form of lymphocyte predominant scarring alopecia which impacts negatively on the quality of life of those affected. It is seen more commonly in women of African descent with prevalence ranging from 2.7% to 5.7%. Current postulates include genetic inheritance, with traction inducing hairstyling practices and hair chemicals as aggravating factors. Histology reveals a perifollicular lymphocytic inflammation of the lower infundibulum, premature desquamation of the inner root sheath, and fibrous connective tissue...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941494/current-understanding-of-the-genetic-causes-of-keloid-formation
#7
REVIEW
Donald A Glass
Keloids are an exuberant response to cutaneous wound healing. Several lines of evidence suggest that keloid scarring is influenced by genetic factors. This review will discuss our current understanding of genetic influences on keloidal scarring via familial inheritance patterns; ethnic differences in prevalence; syndromes with keloid occurrence; linkage analysis, genome-wide association studies, and admixture mapping studies; transforming growth factor beta and p53 variant studies; and human leukocyte antigen polymorphisms...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941493/diversity-in-dermatology-residency-programs
#8
REVIEW
Abby S Van Voorhees, Clinton W Enos
Given the change in our population to one that is more racially and ethnically diverse, the topic of diversity in dermatology residency programs has gained attention. In a field that has become highly competitive, diversity is lagging behind. What are the reasons for this? The existing diversity among medical school matriculants is reflective of the applicant pool, and although modest, there has been an increase in applications and acceptances from minority populations. However, these proportions do not carry through to the population applying to dermatology residency...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941492/replenishing-regulatory-t-cells-to-halt%C3%A2-depigmentation-in-vitiligo
#9
REVIEW
I Caroline Le Poole, Shikhar Mehrotra
Vitiligo is a cutaneous autoimmune disease, especially devastating to patients with darker skin tones because of the contrast between unaffected and lesional skin. We studied immune cells infiltrating vitiligo skin and found very few regulatory T cells (Tregs). Vitiligo was not associated with a reduced frequency or function of circulating Tregs. To manipulate Treg function, we used mouse models expressing melanocyte-reactive TCRs, following changes in pelage color. We also isolated splenocytes to measure Treg function and evaluated cutaneous Treg abundance...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941491/vitiligo-surgery-shuffling-melanocytes
#10
REVIEW
Amanda F Nahhas, Tasneem F Mohammad, Iltefat H Hamzavi
Vitiligo is a disorder characterized by the development of depigmented macules and patches secondary to melanocyte destruction. Several treatment options are available, including medical, light-based, and surgical therapies, that are often used in combination to achieve maximal repigmentation. Vitiligo surgery is an effective yet underperformed treatment, mainly because of lack of awareness and availability. The purpose of this article is to review one method of vitiligo surgery, the melanocyte-keratinocyte transplantation procedure, and discuss its utility in treating vitiligo...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941490/the-importance-of-patient-registries-in%C3%A2-skin%C3%A2-of-color
#11
REVIEW
Jorge A Hinojosa, Amit G Pandya
Patient registries serve as powerful and cost-effective research tools that can help improve our understanding of disease pathogenesis and treatment. Although patient registries for various dermatologic diseases currently exist, few address diseases affecting primarily skin of color. Establishing patient registries for diseases that affect skin of color is one potential solution to overcoming some of the limitations researchers face when studying these disorders. Here, we present two patient registries in dermatology that may serve as examples of how patient registries can contribute to advancing our understanding of dermatologic diseases...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941489/from-bench-to-bedside-the-hampton-university-skin-of-color-research-institute-2015-skin-of-color-symposium
#12
EDITORIAL
Clinton W Enos, Valerie M Harvey
The Hampton University Skin of Color Research Institute Skin of Color Symposium 2015: From Bench to Bedside was held in Williamsburg, Virginia at the Williamsburg Lodge, November 13-15, 2015. The conference was designed to promote, develop, and advance the education, knowledge, and research of cutaneous disorders disproportionately affecting people of racial and ethnic minority groups. Centered on the theme of "From Bench to Bedside", the symposium provided a program featuring a diverse panel of nationally recognized physician-scientists, basic scientists, and clinicians who updated attendees on the latest research advances across multiple relevant disciplines, including public health, basic science, and the clinical diagnosis and management of select complex and rare dermatologic conditions...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28735619/proceedings-of-the-ninth-world-congress-for-hair-research-2015
#13
REVIEW
Wilma F Bergfeld, Angela M Christiano, Maria K Hordinsky
No abstract text is available yet for this article.
2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551953/industry-perspective-on-alopecia-areata
#14
REVIEW
Amanda T Wagner
Recent advances in our understanding of the autoimmune basis of alopecia areata provide an opportunity to create novel effective pharmaceutical interventions. The current lack of approved therapies for alopecia areata presents a high unmet medical need, as well as a potentially attractive market opportunity. From an industry perspective, achieving clinical proof of concept (PoC) gates investments into larger approval studies. Recent investigator-initiated experience suggests that it may be possible to demonstrate rigorous PoC for new therapies in an attractive time frame with relatively fewer patients than were believed necessary in the past...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551952/development-of-uniform-protocol-for-alopecia-areata-clinical-trials
#15
REVIEW
James A Solomon
Developing a successful treatment for alopecia areata (AA), clearly has not been at the forefront of the agenda for new drug/device development among the pharmaceutical and medical device industry. The National Alopecia Areata Foundation (NAAF), a patient advocacy group, initiated a plan to facilitate and drive clinical research toward finding safe and efficacious treatments for AA. As such, Alopecia Areata Uniform Protocols for clinical trials to test new treatments for AA were developed. The design of the uniform protocol is to accomplish the development of a plug-and-play template as well as to provide a framework wherein data from studies utilizing the uniform protocol can be compared through consistency of inclusions/exclusions, safety, and outcome assessment measures...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551951/prevalence-of-comorbid-conditions-and-sun-induced-skin-cancers-in-patients-with-alopecia-areata
#16
REVIEW
Rose Miller, Ruzica Z Conic, Wilma Bergfeld, Natasha Atanaskova Mesinkovska
Alopecia areata is a multifactorial autoimmune disease causing non-scarring hair loss. Recent genome-wide association studies have pointed to connections between alopecia areata and other autoimmune disorders. Research of clinical conditions positively and negatively associated with alopecia areata is crucial for discovering the pathological mechanisms of disease and further treatment options.
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551950/eosinophilic-esophagitis-another-atopy-related-alopecia-areata-trigger
#17
Omer Ibrahim, Wilma F Bergfeld, Melissa Piliang
Alopecia areata (AA) is associated with atopy in 10-22% of patients, twice the prevalence in the general population. Patients can present with concomitant atopic dermatitis, hay fever, asthma, and even allergies to dust mites. In many cases, severity and flares of these atopic diatheses correlate with severity of AA. Herein we present a patient with AA affected by contemporaneous eosinophilic esophagitis (EoE). EoE is a recently recognized allergic disorder, mediated by eosiniphils and histamine. It is characterized by esophageal dysfunction and intraepithelial microabscesses...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551949/alopecia-areata-registry-accomplishments
#18
EDITORIAL
Vera H Price
No abstract text is available yet for this article.
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551948/clinical-efficacy-of-diphenylcyclopropenone-in-alopecia-areata-retrospective-data-analysis-of-50-patients
#19
Katherine S Chiang, Natasha A Mesinkovska, Melissa P Piliang, Wilma F Bergfeld
Diphenylcyclopropenone (DPCP) is widely considered the most effective topical immunotherapy for refractory or extensive alopecia areata (AA), but questions regarding how long to try DPCP therapy before terminating and what factors are prognostic of therapeutic success still remain unanswered. In this retrospective study of 50 AA patients, we evaluated DPCP efficacy and identified patient factors predictive of therapeutic success/failure. The median duration of DPCP treatment was 3 years, with 47% patients experiencing their first regrowth in the first 6 months of DPCP therapy, 20% between 6 months-1 year, and 8% between 1-2 years...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/26551947/ilk-index-and-regrowth-in-alopecia-areata
#20
Alicia M Stallings, Mara Weinstein Velez, Lori A Fiessinger, Melissa P Piliang, Natasha A Mesinkovska, Angela Kyei, Wilma F Bergfeld
There is insufficient data in the literature concerning optimal intralesional kenalog (ILK) dosing for the treatment of alopecia areata (AA). The purpose of this pilot study was to evaluate the utility of using the ratio of ILK received to initial Severity of Alopecia Tool (SALT) score to guide ILK dosing in patients with AA. Using photographic data from patients at baseline and 4-months follow-up, hair loss in 15 patients treated with AA was retrospectively graded using the SALT scores. The ILK received/initial SALT score (ILK index) was calculated for each patient, and the mean ILK index for patients who experienced significant (≥50%) and suboptimal (<50%) hair regrowth at 4 months follow-up were compared...
November 2015: Journal of Investigative Dermatology. Symposium Proceedings
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