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Evidence-based Medicine

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https://www.readbyqxmd.com/read/28320705/rating-the-certainty-in-evidence-in-the-absence-of-a-single-estimate-of-effect
#1
M Hassan Murad, Reem A Mustafa, Holger J Schünemann, Shahnaz Sultan, Nancy Santesso
When studies measure or report outcomes differently, it may not be feasible to pool data across studies to generate a single effect estimate (ie, perform meta-analysis). Instead, only a narrative summary of the effect across different studies might be available. Regardless of whether a single pooled effect estimate is generated or whether data are summarised narratively, decision makers need to know the certainty in the evidence in order to make informed decisions. In this guide, we illustrate how to apply the constructs of the GRADE (Grading of Recommendation, Assessment, Development and Evaluation) approach to assess the certainty in evidence when a meta-analysis has not been performed and data were summarised narratively...
March 20, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28274954/reflections-on-using-non-inferiority-randomised-placebo-controlled-trials-in-assessing-cardiovascular-safety-of-new-agents-for-treatment-of-type-2-diabetes
#2
Denise Campbell-Scherer
The 2008 Food and Drug Administration (FDA) guidance to industry requires experimental evidence that new agents to treat type 2 diabetes do not have an unacceptable increase in cardiovascular risk. They specify this unacceptable increase to be a risk ratio of 1.3 in non-inferiority trials which may use placebo control. Clinically, this means that if a new agent achieves this threshold of not being 30% worse than placebo it is declared 'non-inferior'. This guidance was in response to safety concerns raised about medications approved on their basis of reducing glycated haemoglobin alone...
March 8, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28270434/semaglutide-is-non-inferior-to-placebo-for-cardiovascular-outcomes-in-patients-with-type-2-diabetes
#3
Denise Campbell-Scherer
No abstract text is available yet for this article.
March 7, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28258067/similar-prostate-cancer-and-all-cause-mortality-in-men-with-localised-prostate-cancer-undergoing-surgery-or-radiation-therapy-versus-active-monitoring-at-10%C3%A2-years-of-follow-up
#4
Philipp Dahm, Dragan Ilic, Timothy Wilt
No abstract text is available yet for this article.
March 3, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28254753/adverse-events-associated-with-mood-stabiliser-treatment-should-be-continuously-monitored-in-patients-diagnosed-with-bipolar-affective-disorder
#5
R E Nielsen, R W Licht
No abstract text is available yet for this article.
March 2, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28242609/pregabalin-is-effective-in-reducing-fibromyalgia-pain
#6
Charles Argoff
No abstract text is available yet for this article.
February 27, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28242608/thalamotomy-using-mri-guided-focused-ultrasound-significantly-improves-contralateral-symptoms-and-quality-of-life-in-essential-tremor
#7
Ludvic Zrinzo
No abstract text is available yet for this article.
February 27, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28228386/both-a-stage-shift-and-changes-in-stage-specific-survival-have-contributed-to-reductions-in-breast-cancer-mortality
#8
Stephen W Duffy, Ruth Etzioni, Peter Sasieni
No abstract text is available yet for this article.
February 22, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28213461/team-based-primary-care-with-integrated-mental-health-is-associated-with-higher-quality-of-care-lower-usage-and-lower-payments-received-by-the-delivery-system
#9
Aimee F English
No abstract text is available yet for this article.
February 17, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28188226/patients-with-coronary-heart-disease-and-very-low-blood-pressure-are-at-increased-risk-of-cardiovascular-events
#10
Kazem Rahimi, Hamid Mohseni
No abstract text is available yet for this article.
February 10, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28167494/practising-evidence-based-medicine-ebm-a-descriptive-analysis-of-medical-students-whole-task-ebm-assignments
#11
Lauren A Maggio, Nicole Capdarest-Arest
Researchers have suggested whole-task learning activities to practice and teach evidence-based medicine (EBM); however, limited description exists of their use in EBM curricula. This article describes medical students' execution of a whole-task EBM assignment and characterises themes emerging from assignment submissions. Between 2013 and 2015, Stanford University's paediatric clerkship students completed a whole-task EBM assignment based on a patient encounter. The assignment captured students' efforts to perform all EBM steps and describe their patient scenario and future knowledge needs strategies...
February 6, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28159856/sglt2-inhibitor-empagliflozin-reduces-renal-outcomes-and-dampens-the-progressive-reduction-in-glomerular-filtration-rate-in-patients-with-type-2-diabetes-and-antecedents-of-cardiovascular-disease
#12
https://www.readbyqxmd.com/read/28159855/passive-leg-raising-may-serve-as-the-primary-method-to-quickly-assess-fluid-responsiveness-in-haemodynamically-unstable-patients
#13
Thomas Gv Cherpanath
No abstract text is available yet for this article.
February 3, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28137732/survey-of-instructions-for-authors-on-how-to-report-an-update-of-a-systematic-review-guidance-is-needed
#14
Dawid Pieper, Tim Mathes
Systematic reviews have become the cornerstone of evidence-based healthcare. Approximately half of the systematic reviews are out of date after 5.5 years, and keeping them up to date remains a huge challenge. Despite new guidance on when and how to update systematic reviews, there seems to be a lack of guidance on how to report updates of systematic reviews. Therefore, we decided to systematically analyse instruction for authors in biomedical journals regarding guidance on reporting updates of systematic reviews...
January 30, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28130388/stress-management-training-should-be-an-integral-component-of-cardiac-rehabilitation
#15
Barbara M Murphy
No abstract text is available yet for this article.
January 27, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28130387/high-dose-sulphonylurea-treatment-in-patients-with-renal-impairment-should-be-considered-with-caution
#16
Gyuri Kim, Eun Seok Kang
No abstract text is available yet for this article.
January 27, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28122797/single-dose-of-prophylactic-oral-dextrose-gel-reduces-neonatal-hypoglycaemia
#17
Praveen Chandrasekharan, Satyan Lakshminrusimha
No abstract text is available yet for this article.
January 25, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28122796/nasal-continuous-positive-airway-pressure-outperforms-heated-high-flow-nasal-cannula-therapy-as-primary-respiratory-therapy-in-preterm-infants
#18
Sarah J Kotecha, Mallinath Chakraborty, Sailesh Kotecha
No abstract text is available yet for this article.
January 25, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28073867/the-maimed-martian-credible-intervals-and-bias-against-benefit
#19
David Kault
A sad little story about a maimed Martian astronaut is used to illustrate a method of improving confidence interval (CI) calculations. CIs in medical statistics are currently calculated from the data available in a clinical trial or meta-analysis considered in isolation from all other information available on earth. Likewise, the Martian in the story uses only information available to it, in isolation from further information from earth. However, there is further objective knowledge available to people on earth to improve the Martian's estimate...
January 10, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28073866/in-simulation-modelling-there-are-multiple-ways-to-effectively-screen-for-colorectal-cancer
#20
Theodore R Levin
No abstract text is available yet for this article.
January 10, 2017: Evidence-based Medicine
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