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Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy

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https://www.readbyqxmd.com/read/29773440/case-report-identification-of-recombinant-hcv-genotype-1b-2b-by-viral-sequencing-in-two-patients-with-treatment-failure-who-responded-to-re-treatment-with-sofosbuvir-and-daclatasvir
#1
Luis Antonio Uribe-Noguez, Alicia Ocaña-Mondragón, José Antonio Mata-Marín, Allison Cázares-Cortázar, Rosa María Ribas-Aparicio, María Elena Gómez-Torres, Jesus Gaytán-Martínez, María de la Luz Martínez-Rodríguez
Hepatitis C virus (HCV) infection is a global health problem. HCV has been classified into seven genotypes and >67 subtypes. Genotyping is necessary to enable selection of appropriate treatments. The commercial molecular techniques currently used do not identify some HCV subtypes, mixed infections and recombinant forms. In this study, the core-E1 and NS5B regions were sequenced and phylogenetically analysed to identify infections by HCV recombinant genotype 1b-2b in two patients who had initially been diagnosed with HCV genotype 2 infection by reverse hybridization with a Versant HCV Genotype 2...
May 15, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29773439/the-evaluation-of-frequency-of-nephrotoxicity-caused-by-liposomal-amphotericin-b
#2
Hideo Kato, Mao Hagihara, Yuka Yamagishi, Yuichi Shibata, Yukiko Kato, Tatsuro Furui, Hiroki Watanabe, Nobuhiro Asai, Yusuke Koizumi, Hiroshige Mikamo
BACKGROUND: Liposomal amphotericin B (L-AmB) was developed to reduce nephrotoxicity and maximize the therapeutic utility of amphotericin B in the treatment of invasive fungal infections. However, there is little investigation into the safety of L-AmB in patients with several renal functions. Therefore, we retrospectively evaluated the clinical safety of L-AmB among patients with several renal functions. METHODS: We divided patients treated with L-AmB from April 2014 to September 2016 into 4 groups (estimated glomerular filtration rate (eGFR)≥60, 60 > eGFR≥30, eGFR<30 and hemodialysis)...
May 14, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29759898/risk-factors-for-human-papillomavirus-detection-in-urine-samples-of-heterosexual-men-visiting-urological-clinics-in-japan
#3
Kazufumi Nakashima, Kazuyoshi Shigehara, Tadaichi Kitamura, Hiroshi Yaegashi, Masayoshi Shimamura, Shohei Kawaguchi, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
OBJECTIVE: The present study aimed to investigate human papillomavirus (HPV) prevalence and identify risk factors for HPV detection in urine samples among heterosexual men attending urological clinics. MATERIALS AND METHODS: Spot urine samples including initial stream were collected from 845 participants, and the cell pellets were preserved into liquid-based cytological solution. After DNA extraction from each sample, HPV-DNA amplification and genotyping were performed using Luminex multiplex polymerase chain reaction...
May 11, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29759897/in-vitro-neuraminidase-inhibitory-concentration-ic-50-of-four-neuraminidase-inhibitors-in-the-japanese-2016-17-season-comparison-with-the-2010-11-to-2015-16-seasons
#4
Hideyuki Ikematsu, Naoki Kawai, Norio Iwaki, Seizaburo Kashiwagi, Yusuke Ishikawa, Hiroki Yamaguchi, Kazuhito Shiosakai
To assess the extent of susceptibility to the four most commonly used neuraminidase inhibitors (NAIs) in the viruses epidemic in the 2016-17 Japanese influenza season, we measured the 50% inhibitory concentration (IC50 ) of these NAIs for influenza virus isolates from patients and compared them with the results from the 2010-11 to 2015-16 seasons. Viral isolation was done with specimens obtained prior to treatment, and the type and subtype was determined by RT-PCR using type- and subtype-specific primers. The IC50 was determined by a neuraminidase inhibition assay using a fluorescent substrate...
May 11, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29753615/targeting-the-proinflammatory-cytokines-oxidative-stress-apoptosis-and-tgf-%C3%AE-1-stat-3-signaling-by-irbesartan-to-ameliorate-doxorubicin-induced-hepatotoxicity
#5
Ahmed M Kabel, Abdulaziz A Alzahrani, Nawaf M Bawazir, Rayan O Khawtani, Hany H Arab
Doxorubicin (DOX) is an anthracycline antibiotic that is used frequently for treatment of various types of malignancies. Hepatotoxicity is one of the serious complications of DOX. The aim of this study was to explore the effect of different doses of irbesartan on doxorubicin-induced hepatotoxicity in mice. Sixty male BALB/c mice were divided into six equal groups as follows: Control group; DOX group; Irbesartan (Small dose) group; Irbesartan (Large dose) group; DOX + Irbesartan (Small dose) group and DOX + Irbesartan (Large dose) group...
May 9, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29752197/panophthalmitis-caused-by-streptococcus-dysgalactiae-subsp-equisimilis-a-case-report-and-literature-review
#6
Hideharu Hagiya, Takuya Semba, Takeshi Morimoto, Norihisa Yamamoto, Hisao Yoshida, Kazunori Tomono
Lancefield group G β-hemolytic Streptococcus dysgalactiae subspecies equisimilis (SDSE) has become a leading causative pathogen of invasive streptococcal infection. In this report, we describe a case of disseminated SDSE infection complicated by endogenous endophthalmitis, resulting in panophthalmitis and blindness. A 65-year-old man who underwent mitral valve replacement surgery two months previously was hospitalized due to high fever and right visual loss. A systemic investigation revealed endophthalmitis complicated by mediastinal abscess, prosthetic infective endocarditis, cerebral emboli and hemorrhage, and multiple arthritis...
May 8, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29752196/acute-focal-bacterial-nephritis-characterized-by-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion
#7
Hiroshi Yamaguchi, Hiroaki Nagase, Yusuke Ito, Natsuki Matsunoshita, Makoto Mizutani, Takeshi Matsushige, Yusuke Ishida, Daisaku Toyoshima, Masashi Kasai, Hiroshi Kurosawa, Azusa Maruyama, Kazumoto Iijima
Acute focal bacterial nephritis (AFBN) is a localized bacterial infection of the kidney presenting as an inflammatory mass, and some patients show deterioration of clinical condition with neurological symptoms. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a syndrome that is characterized by biphasic seizures and impaired consciousness with reduced diffusion in the subcortical white matter on magnetic resonance imaging, typically observed between days 3 and 9 after clinical onset...
May 8, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29739646/presepsin-a-new-marker-of-catheter-related-blood-stream-infections-in-pediatric-patients-reply-to-rivera-moran-javier-et-al
#8
LETTER
Sevgen Tanır Basaranoglu, Eda Karadag-Oncel, Kubra Aykac, Yasemin Ozsurekci, Ahmet Emre Aycan, Ali Bulent Cengiz, Ates Kara, Mehmet Ceyhan
No abstract text is available yet for this article.
May 5, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29735300/clinical-factor-associated-with-congenital-cytomegalovirus-infection-in-pregnant-women-with-non-primary-infection
#9
Hideto Yamada, Kenji Tanimura, Shinya Tairaku, Ichiro Morioka, Masashi Deguchi, Mayumi Morizane, Satoshi Nagamata, Kana Ozaki, Yasuhiko Ebina, Toshio Minematsu
The aim of this nested case-control study was to evaluate clinical factors associated with the occurrence of congenital cytomegalovirus (CMV) infection in pregnant women with non-primary CMV infection. In a cohort study of CMV screening for 2193 pregnant women and their newborns, seven newborns with congenital CMV infection were identified among 1287 pregnant women with non-primary CMV infection that was defined as negative IgM and positive IgG with IgG avidity index >45%. In the 1287 women with non-primary CMV infection, clinical findings and complications were compared between pregnancies with and without congenital CMV infection...
May 5, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29724485/presepsin-a-new-marker-of-catheter-related-blood-stream-infections-in-pediatric-patients
#10
LETTER
Rivera-Morán Javier, Montero-Miranda Diego, Maguiña Jorge L
No abstract text is available yet for this article.
April 30, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29716812/first-report-of-the-isolation-of-bla-imi-1-producing-colistin-heteroresistant-enterobacter-cloacae-in-japan-september-2016
#11
Norihito Tarumoto, Masahiro Kodana, Noriyuki Watanabe, Jun Sakai, Kazuo Imai, Toshiyuki Yamaguchi, Yoshitada Taji, Yasuhiro Ebihara, Takashi Murakami, Takuya Maeda, Kotaro Mitsutake, Shigefumi Maesaki
The isolation of a carbapenem-resistant Enterobacter cloacae strain harboring the IMI-1 variant of blaIMI-1 carbapenemase points to the worldwide emergence of multidrug resistant bacteria as a potential source of health care infections. In this report, we describe the first isolation of E. cloacae with blaIMI-1 carbapenemase isolated from a Japanese patient in September 2016. The isolate was resistant to carbapenems, levofloxacin, and aminoglycosides, and heteroresistant to colistin but sensitive to fourth-generation cephalosporins...
April 28, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29709375/purulent-lymphadenitis-caused-by-staphylococcus-argenteus-representing-the-first-japanese-case-of-staphylococcus-argenteus-multilocus-sequence-type-2250-infection-in-a-12-year-old-boy
#12
Takuma Ohnishi, Masayoshi Shinjoh, Hirotoshi Ohara, Toshinao Kawai, Isamu Kamimaki, Ryo Mizushima, Keisuke Kamada, Yasutomo Itakura, Shigekazu Iguchi, Yutaka Uzawa, Atsushi Yoshida, Ken Kikuchi
Staphylococcus argenteus is a novel species separated from a strain of coagulase-positive, non-pigmented S. aureus. Although S. argenteus has been reported to occur globally, multilocus sequence type (ST) 2250 is mainly found in Northeastern Thailand. Because conventional biochemical testing misidentifies this pathogen as S. aureus, multilocus sequence typing (MLST) or nucA sequencing is recommended to distinguish between S. argenteus and S. auereus. The patient was a previously healthy 12-year-old boy who was admitted because of right inguinal lymphadenitis and cellulitis...
April 27, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29705393/diagnostic-scoring-system-for-tuberculous-meningitis-among-adult-patients-with-non-suppurative-and-non-bacterial-meningitis
#13
Sarunyou Chusri, Thanaporn Hortiwakul, Natthaka Sathaporn, Boonsri Charernmak, Manthana Phengmak, Walailuk Jitpiboon, Alan Frederick Geater
Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis. The definite diagnosis of this disease is difficult and can result in delayed treatment. Conventional culture yields low sensitivity while high-sensitivity diagnostic techniques are costly and unpractical. Adenosine deaminase (ADA) is used to diagnose several settings of extra-pulmonary tuberculosis but it is limited in TBM especially among HIV-infected patients. We retrospectively reviewed the data of patients with non-suppurative meningitis and compared the patient data with TBM and other causes including carcinomatous, lymphomatous, lymphocytic and fungal meningitis...
April 25, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29705392/risk-stratification-for-the-development-of-chronic-pulmonary-aspergillosis-in-patients-with-mycobacterium-avium-complex-lung-disease
#14
Koji Furuuchi, Akihiro Ito, Toru Hashimoto, Shogo Kumagai, Tadashi Ishida
BACKGROUND: The number of patients with pulmonary nontuberculous mycobacterial disease complicated by chronic pulmonary aspergillosis (CPA) has been increasing. Additionally, CPA is reportedly associated with mortality in patients with Mycobacterium avium complex lung disease (MAC-LD). In the present study, we aimed to identify risk factors for developing CPA and stratify the risk for CPA development in patients with MAC-LD. METHODS: We retrospectively examined 361 patients newly diagnosed with MAC-LD...
April 25, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29705391/stability-of-benzylpenicillin-potassium-and-ampicillin-in-an-elastomeric-infusion-pump
#15
Tomomi Nakamura, Yuki Enoki, Shunsuke Uno, Yoshifumi Uwamino, Osamu Iketani, Naoki Hasegawa, Kazuaki Matsumoto
Some infectious diseases, such as infective endocarditis, osteomyelitis, and abscesses, require treatment with long-term intravenous antimicrobial treatment. Therefore, the patient is required to stay in the hospital to receive therapy, which lowers their quality of life. Establishing an outpatient parenteral antimicrobial therapy (OPAT) by continuous infusion pump is desired in Japan to overcome these issues. However, the 24-h stability of antimicrobial agents dissolved in infusion solutions is unclear. Thus, we investigated the stability of antimicrobial agents in five different infusion solutions in a clinical setting...
April 25, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29703650/lung-abscess-following-bronchoscopy-due-to-multidrug-resistant-capnocytophaga-sputigena-adjacent-to-lung-cancer-with-high-pd-l1-expression
#16
Yohei Migiyama, Moriyasu Anai, Kosuke Kashiwabara, Yusuke Tomita, Sho Saeki, Kazuyoshi Nakamura, Shinichiro Okamoto, Hidenori Ichiyasu, Kazuhiko Fujii, Hirotsugu Kohrogi
Lung abscess following flexible bronchoscopy is a rare and sometimes fatal iatrogenic complication. Here, we report the first case of a lung abscess caused by multidrug-resistant Capnocytophaga sputigena following bronchoscopy. A 67-year-old man underwent bronchoscopy to evaluate a lung mass. Seven days after transbronchial lung biopsy, he presented with an abscess formation in a lung mass. Empirical antibiotic therapy, including with garenoxacin, ampicillin/sulbactam, clindamycin and cefepime, was ineffective...
April 24, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29685855/molecular-epidemiologic-study-of-clostridium-difficile-infections-in-university-hospitals-results-of-a-nationwide-study-in-japan
#17
Issei Tokimatsu, Katsumi Shigemura, Kayo Osawa, Shinya Kinugawa, Koichi Kitagawa, Noriko Nakanishi, Hiroyuki Yoshida, Soichi Arakawa, Masato Fujisawa
We conducted a nationwide molecular epidemiological study of Clostridium difficile infection (CDI) in Japan investigated the correlation between the presence of binary toxin genes and CDI severity. This is the first report on molecular epidemiological analyses for CDI in multiple university hospitals in Japan, to our knowledge. We examined 124,484 hospitalized patients in 25 national and public university hospitals in Japan between December 2013 and March 2014, investigating antimicrobial susceptibilities and toxin-related genes for C...
April 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29685854/distribution-of-tick-borne-diseases-in-japan-past-patterns-and-implications-for-the-future
#18
REVIEW
Kayoko Yamaji, Hiroka Aonuma, Hirotaka Kanuka
The rapid geographical spread of tick-borne diseases (TBDs) worldwide has recently provoked significant concerns amongst public health authorities. Tick-borne pathogens are maintained in enzootic cycles involving ticks and wild animal hosts, with epizootic spread to other mammals, including livestock and humans. Despite the increasing public health concern, current TBD diagnostic tests and treatments are inadequate, and predictive models of future risks posed by TBDs are limited by the heterogeneity of environmental, vector, and host factors, even in neighboring regions...
April 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29685853/a-successful-antimicrobial-therapeutic-strategy-for-the-discitis-caused-by-aggregatibacter-actinomycetemcomitans-under-unknown-drug-susceptibility-a-case-report
#19
Shunsuke Uno, Yosuke Horiuchi, Takae Uchida, Akiko Yonaha, Takanori Miyata, Eiko Nagano, Takao Kodama, Naoki Hasegawa
Aggregatibacter actinomycetemcomitans is well-known as the pathogen of gingivitis or periodontitis, and discitis or vertebral osteomyelitis cases caused by this organism have rarely been reported. Ampicillin or amoxicillin has been used in the previously reported discitis cases; however, no cases have been reported that is treated with levofloxacin. We report the first published case we chose levofloxacin to treat. We failed to perform the susceptibility testing because of the poor growth and fastidious nature of the organism, and the result of susceptibility of amoxicillin was unclear...
April 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29685852/assessment-of-antimicrobiral-prophylaxis-in-transperineal-prostate-biopsy-a-single-center-retrospective-study-of-485-cases
#20
Kyoko Baba, Yoshitaka Sekine, Yoshiyuki Miyazawa, Takahiro Syuto, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
To verify the validity of our antimicrobial prophylaxis regimen for transperineal prostate biopsies, we investigated the rate of infectious complications in this procedure. We retrospectively investigated the infectious complications in 485 patients who underwent a transperineal prostate biopsy between 2014 and 2016 at our hospital. In the clinic, we use cefazolin (CEZ) for antimicrobial prophylaxis. Infectious complications were assessed up to postoperative day (POD) 30. Patients with infectious complications were further investigated to determine the site of infection, outbreak day, and type of pathogenic bacteria...
April 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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