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Journals
Journal of Infection and Chemo...
Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
#1
JOURNAL ARTICLE
Waki Imoto, Yasutaka Ihara, Takumi Imai, Mitsuhiro Tamoto, Tatoi Ibuki, Koichi Yamada, Yukihiro Kaneko, Ayumi Shintani, Hiroshi Kakeya
INTRODUCTION: Obesity is a risk factor for aggravation of and mortality from coronavirus disease 2019 (COVID-19). We aimed to investigate the relationship between COVID-19 and Body Mass Index (BMI) in the Japanese population. METHODS: We used administrative claims data from an advanced treatment hospital in Japan and extracted data from patients hospitalized for COVID-19. The exposure variable was BMI measured at the time of admission, and the study outcomes were progression to critical illness and death...
April 16, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#2
JOURNAL ARTICLE
Magdalena Grochowska, Agnieszka Strzelak, Katarzyna Krenke
BACKGROUND: An increased incidence of group A Streptococcus (GAS) infections has been observed in pediatric population post-COVID-19 pandemic. While the majority of reports refer to scarlet fever or invasive GAS disease, detailed data on pulmonary manifestations such as complicated community-acquired pneumonia (CAP) are scarce. The aim of this study was to assess the contribution of GAS to complicated CAP in children during the 2022/2023 infectious season. METHODS: We retrospectively analyzed the etiology and clinical presentation of complicated CAP patients hospitalized in our tertiary care center in Warsaw, Poland, between August 2022 and May 2023...
April 15, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#3
Motohiro Shingu, Chieko Fujishima, Shigeo Hara, Hiroaki Nishioka
Japanese spotted fever is an emerging rickettsiosis caused by Rickettsia japonica and is characterized by high fever, rash, and eschar formation. Other symptoms are often vague and nonspecific and include headaches, nausea, vomiting, and myalgia. We present a case of a 46-year-old woman with Japanese spotted fever, complicated by transient bilateral sensorineural hearing loss and presenting cutaneous IgM/IgG immune complex vasculitis. The patient was admitted with a history of several days of high fever, generalized skin erythema, and hearing impairment...
April 8, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#4
JOURNAL ARTICLE
Kanao Kobayashi, Satoshi Takahashi, Mitsuru Yasuda, Jun Miyazaki, Koichiro Wada, Masahiro Matsumoto, Hiroshi Hayami, Shingo Yamamoto, Hiroshi Kiyota, Junko Sato, Tetsuya Matsumoto, Naoki Hasegawa, Intetsu Kobayashi, Naoya Masumori, Takahiro Kimura, Hiroki Yamada, Tohru Nakagawa, Tomoyuki Kaneko, Kazumasa Matsumoto, Tetsuya Fujimura, Jun Kamei, Kiyohito Ishikawa, Kiyohide Fujimoto, Yasushi Nakai, Katsumi Shigemura, Takuya Sadahira, Nobuyuki Hinata, Hiroyuki Kitano, Masuo Yamashita, Tomihiko Yasufuku, Hisao Komeda, Yoshiki Hiyama, Yoshito Takahashi, Sojun Kanamaru, Masaya Murakami, Soichi Arakawa, Daisuke Yamada, Koji Mita, Ryoichi Hamasuna, Kazushi Tanaka, Masanori Matsukawa, Eiichiro Takaoka, Masanobu Shigeta, Tadasu Takenaka, Masashi Nishino, Satoshi Ishitoya, Shohei Hayakawa, Kazuhiro Okumura, Masakatsu Ueda
INTRODUCTION: Antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using the national surveillance data, comprising 793 bacterial strains from eight clinically relevant species. MATERIALS AND METHODS: Data were collected for the fourth national surveillance project from July 2020 to December 2021 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology...
April 6, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#5
JOURNAL ARTICLE
Yusuke Okubo, Yosuke Nakabayashi, Kenta Ito, Kazuhiro Uda, Isao Miyairi
BACKGROUND: The COVID-19 pandemic posed substantial challenges to healthcare systems. Understanding the responses of pediatric health services is crucial for future pandemic planning and preparedness, yet such data remains limited. METHODS: In this retrospective cohort study, we analyzed data from administrative databases developed by Japan Medical Data Center and DeSC Healthcare Inc. The dataset comprised records of 2,612,511 children, totaling 60,224,888 person-months, from January 2020 to May 2022...
April 6, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#6
Yoshito Homma, Takashi Harada, Takeshi Inoue, Junya Nakamura, Haruka Kondo, Sayaka Tachibana, Tomoya Katsuta, Koji Inoue
A tuberculous aneurysm is an uncommon extrapulmonary tuberculosis and is usually fatal. The best way to treat it involves a combination of open surgery and medical treatment. However, it can be challenging to diagnose a tuberculous aneurysm. In this report, we describe a patient with a tuberculous aneurysm who was treated with stent-graft replacement and CT-guided biopsy for diagnosis, followed by nine months of anti-tuberculosis therapy. Despite one week of anti-tuberculous therapy, her fever persisted. A CT scan revealed new, well-defined nodules measuring 1-2mm in the lungs and hepatomegaly, indicating complications of miliary tuberculosis...
April 5, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#7
JOURNAL ARTICLE
Nami Miura-Ajima, Pondpan Suwanthada, Siriporn Kongsoi, Hyun Kim, Ruttana Pachanon, Kentaro Koide, Shigetarou Mori, Jeewan Thapa, Chie Nakajima, Yasuhiko Suzuki
INTRODUCTION: Campylobacteriosis stands as one of the most frequent bacterial gastroenteritis worldwide necessitating antibiotic treatment in severe cases and the rise of quinolones-resistant Campylobacter jejuni poses a significant challenge. The predominant mechanism of quinolones-resistance in this bacterium involves point mutations in the gyrA, resulting in amino acid substitution from threonine to isoleucine at 86th position, representing more than 90% of mutant DNA gyrase, and aspartic acid to asparagine at 90th position...
April 3, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#8
JOURNAL ARTICLE
Yoshiro Hadano, Tatsuyuki Kakuma
INTRODUCTION: The objective of this study is to evaluate the epidemiological characteristics of Japanese Spotted Fever (JSF) cases reported through the National Epidemiological Surveillance of Infectious Disease (NESID) system in Shimane Prefecture, Japan, from 2000 to 2022, encompassing the periods before and during the COVID-19 pandemic period. METHODS: A retrospective analysis was conducted on JSF cases reported to the NESID system in Shimane Prefecture between 2000 and 2022...
April 2, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#9
Takeshi Kawaguchi, Yuki Rikitake, Mao Rikitake, Masatoshi Kimura, Chihiro Iwao, Kosho Iwao, Ayako Aizawa, Makoto Sumiyoshi, Yumi Kariya, Motohiro Matsuda, Shunichi Miyauchi, Kunihiko Umekita, Ichiro Takajo, Norio Ohashi, Taiga Miyazaki
Human granulocytic anaplasmosis (HGA) is a tick-borne infection caused by Anaplasma phagocytophilum. Only seven cases of HGA have been reported in Japan to date. We report the case of a 61-year-old female farmer who developed HGA with rash and rhabdomyolysis. The patient had fever and erythema covering the entire body, including the palms. An induration with an eschar was observed on the right leg, indicating that the patient had been bitten by a tick. Elevated serum creatinine and creatinine kinase levels and hematuria indicated rhabdomyolysis...
April 2, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#10
JOURNAL ARTICLE
Goh Murayama, Makio Kusaoi, Yuki Horiuchi, Yoko Tabe, Toshio Naito, Suminobu Ito, Ken Yamaji, Naoto Tamura
INTRODUCTION: To control the spread of severe disease caused by mutant strains of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), it is necessary to determine whether continued vaccination enhances humoral and cellular immunity. AIM: In this study, we examined the changes in humoral and cellular immunity to SARS-CoV-2 after administration of the third vaccination in Japanese adults who had received the second dose of messenger ribonucleic acid (mRNA)-1273 vaccine and the third vaccination (BNT162b2 or mRNA-1273)...
April 1, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#11
Hiroki Harada, Kaito Nakamura, Yuki Koyama, Koki Kikuchi, Hiroyuki Iwano, Mirei Nabuchi-Kawasaki, Yuta Kubono, Megumi Sano, Yoshimoto Serizawa, Hoshi Tetsuya
Infective endocarditis (IE) is a life-threatening disease that affects the endocardial surface of the heart. Although heart valves are commonly involved in IE, in rare cases, vegetation is attached to the cardiac walls without valvular endocardial involvement, which is referred to as mural IE. In this case, a 60-year-old female presented with a seven-day history of fever associated with worsening pain in the right shoulder and left hip. Streptococcus dysgalactiae subsp. Equisimilis was detected in both blood and joint fluid cultures...
April 1, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#12
JOURNAL ARTICLE
In Young Yoo, Sung-Il Ha, Suhng-Wook Kim, Jae Kwon Kim, Hyun Soo Seok, Yeon-Joon Park
We aimed to assess the accuracy of BD Phoenix for determining carbapenem susceptibility because we observed a decline in carbapenemase susceptibility rate from the biannual cumulative data, after we transitioned to the BD Phoenix form Vitek 2 system. Between October 2021 and May 2022, we collected 82 non-duplicated Enterobacterales showing non-susceptible to at least one of the three carbapenems by BD Phoenix. We performed the broth microdilution (BMD) and disk diffusion (DD) according to the CLSI guideline...
April 1, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#13
Naonori Harada, Ikumi Shibano, Yuto Izuta, Yusuke Kizawa, Hiroshi Shiragami, Akiko Tsumura, Goh Ohji, Atsuko Mugitani
Epstein-Barr virus (EBV) reactivation in COVID-19 patients has been reported, but studies on its clinical significance are lacking. We herein report the occurrence of infectious mononucleosis (IM) due to EBV reactivation in a 60-year-old man with rheumatoid arthritis being treated with methotrexate and tocilizumab. The patient presented with a fever and tested positive for COVID-19. Laboratory findings revealed an increased atypical lymphocyte count, decreased platelet count, and elevated liver enzyme levels...
April 1, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#14
Naoya Itoh, Nana Akazawa, Makoto Yamaguchi, Yuichi Ishibana, Hiromi Murakami, Kiyofumi Ohkusu, Misako Ohkusu, Naruhiko Ishiwada
Salmonella enterica subspecies enterica serovar Choleraesuis (S. Choleraesuis) is a nontyphoidal Salmonella pathogen that causes swine paratyphoids. S. Choleraesuis is a zoonotic pathogen transmitted to humans via contaminated food and causes sepsis. Here, we report a rare case of pyelonephritis caused by S. Choleraesuis in a Japanese patient with a carcinoma of unknown primary origin. On the day of admission, the patient was diagnosed with pyelonephritis associated with ureteral stent obstruction. He had no history of raw pork consumption or gastrointestinal symptoms...
March 28, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#15
JOURNAL ARTICLE
Shota Matsuya, Shunsuke Kawahata, Yoshiaki Takeda
INTRODUCTION: Estimating the serum vancomycin (VCM) concentrations of lean and patients with obesity is challenging. Additionally, VCM dosing for Japanese patients undergoing hemodialysis remains particularly unclear. This study aimed to determine the impact of the physical build on serum VCM concentrations of Japanese patients undergoing hemodialysis. METHODS: This retrospective cohort study included hospitalized patients undergoing hemodialysis, who received treatment with VCM between May 1, 2019, and December 31, 2021, at Kansai Rosai Hospital, which is a 642-bed acute care hospital in Japan...
March 27, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#16
JOURNAL ARTICLE
Thamer A Almangour, Leen Ghonem, Dareen Alassiri, Alanoud Aljurbua, Mohammed Al Musawa, Aminah Alharbi, Sara Almuhisen, Jeelan Alghaith, Nader Damfu, Doaa Aljefri, Wafa Alfahad, Marwan Alrasheed, Yaqoub Khormi, Abdullah Almohaizeie
BACKGROUND: Data comparing the clinical outcomes of novel β-lactam-β-lactamase inhibitors given in combination versus monotherapy for the treatment of multidrug-resistant (MDR) P. aeruginosa infections are lacking. METHOD: This retrospective cohort study included patients who received novel β-lactam-β-lactamase inhibitors as monotherapy or in combination for the treatment of MDR P. aeruginosa infections. The study was conducted between 2017 and 2022 in 6 tertiary care hospitals in Saudi Arabia...
March 25, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#17
JOURNAL ARTICLE
Makito Kaneda, Kentaro Nagaoka, Rinako Yoshida, Yosuke Iwasaki, Hideki Niimi, Yoshihiro Yamamoto
BACKGROUND: Time-dependent changes in cell populations during acute bacterial infections remain unclear. We assessed time-dependent changes in fluorescent light intensity of the neutrophil area (NE-SFL) and fluorescent light distribution width index of the neutrophil area (NE-WY) and their association with sepsis and bacteremia. METHODS: Patients with acute bacterial infections were enrolled in this prospective, observational cohort study. Blood samples were collected from all patients at the onset of bacterial infections (day 0) and on days 1 and 3...
March 22, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#18
JOURNAL ARTICLE
Keisuke Kadokura, Hirofumi Kato, Kayoko Yoshizumi, Miyuki Kamikuri, Akira Kamenosono, Naomi Shinkawa, Yuka Hamada, Hideki Kawamura, Tomoe Shimada, Makoto Kuroda, Tomimasa Sunagawa
INTRODUCTION: During COVID-19 pandemic in Japan, nightclubs were identified as high-risk locations for COVID-19 outbreaks, but an outbreak investigation in this setting is challenging because of the anonymous and opportunistic nature of interactions. METHODS: The joint rapid response team collected epidemiological data, conducted descriptive epidemiology to determine the characteristics of cases associated with the nightclub, and implemented countermeasures. Polymerase chain reaction (PCR) tests were performed by the Local Institute of Public Health, Kagoshima University, and several commercial laboratories...
March 21, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#19
JOURNAL ARTICLE
Minkyeong Lee, Chan Mi Lee, Ja Min Byun, Dong-Yeop Shin, Youngil Koh, Junshik Hong, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Sung-Soo Yoon, Myoung-Don Oh, Chang Kyung Kang, Inho Kim
BACKGROUND: Gram-positive bacteria are frequently resistant to empirical beta-lactams in febrile neutropenic patients with cancer. As microbiology and antibiotic susceptibility changes, we reevaluated the risk factors for resistant Gram-positive bacteremia in febrile neutropenic patients with cancer. METHODS: Episodes of bacteremic febrile neutropenia in Seoul National University Hospital from July 2019 to June 2022 were reviewed. Resistant Gram-positive bacteria were defined as a pathogen susceptible only to glycopeptide or linezolid in vitro (e...
March 20, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#20
Kyosuke Yamaguchi, Hisashi Yamamoto, Koji Izutsu, Mitsuhiro Yuasa, Daisuke Kaji, Aya Nishida, Kazuya Ishiwata, Shinsuke Takagi, Go Yamamoto, Yuki Asano-Mori, Naoyuki Uchida, Shuichi Taniguchi
BK virus (BKV) encephalitis is a rare complication after hematopoietic stem cell transplantation (HSCT). A 43-year-old woman with recurrent follicular lymphoma after autologous HSCT received allogeneic bone marrow transplantation from a human leukocyte antigen-matched related donor. Neutrophil engraftment was achieved on post-transplant day 13. Memory loss and noncooperative attitude toward the medical staff were observed on day 16, and her mental status worsened progressively. Magnetic resonance imaging (MRI) showed nonspecific findings on day 19; however, cerebrospinal fluid (CSF) analysis including real-time polymerase chain reaction on day 20 revealed elevated levels of BKV 4...
March 19, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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