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Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy

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https://www.readbyqxmd.com/read/28811073/quality-of-life-of-people-living-with-hiv-compared-with-that-of-the-general-population-in-japan
#1
Shinichi Hikasa, Shota Shimabukuro, Kyoko Hideta, Norihiro Kuroda, Satoshi Higasa, Akihiro Sawada, Tazuko Tokugawa, Asuka Ikegami, Asuna Kotani, Takeshi Kimura
OBJECTIVE: To evaluate the health-related quality of life (HRQOL) of people living with HIV (PLWH) in Japan. METHODS: A cross-sectional comparative study was conducted between June and December 2016 on PLWH. HRQOL was assessed using the Japanese version of the Short Form-36 Health Survey questionnaire (SF-36), and the three-component model of SF-36 scores was used. The values from the present study were compared with the published general Japanese values. Multivariate analysis was performed to identify the independent factors associated with the HRQOL of PLWH...
August 12, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28807755/antimicrobial-susceptibility-of-pathogens-in-acute-uncomplicated-cystitis-cases-in-the-urology-department-of-a-community-hospital-in-japan-comparison-with-treatment-outcome-and-hospital-wide-antibiogram
#2
Toshiki Etani, Taku Naiki, Sachiyo Yamaguchi, Saori Mori, Takashi Nagai, Keitaro Iida, Ryosuke Ando, Noriyasu Kawai, Keiichi Tozawa, Tohru Mogami, Takahiro Yasui
We hypothesized that cases of uncomplicated cystitis treated in a Urology Department would display higher antimicrobial susceptibility than those reported by the hospital antibiogram. This would suggest narrow spectrum antibiotics could still be an effective treatment for uncomplicated cystitis despite this era of antimicrobial resistance. The objective of this study was thus to evaluate the rates of antimicrobial susceptibility of isolates cultured from uncomplicated cystitis cases that presented to the Urology Department of a community hospital in Japan...
August 11, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28803866/pericarditis-caused-by-campylobacter-fetus-subspecies-fetus-associated-with-ingestion-of-raw-beef-liver
#3
Yoshihiko Kiyasu, Daiki Akiyama, Yoko Kurihara, Hiroshi Koganemaru, Shigemi Hitomi
Campylobacter fetus is an organism residing primarily in the gastrointestinal tracts of cattle and sheep and transmitting to humans through ingestion of contaminated food products or surface water. The organism has caused various extraintestinal infections but, to date, purulent pericarditis due to the organism has rarely been described. We report a case of purulent pericarditis due to C. fetus subsp. fetus, occurring in a patient having several predisposing conditions, including receiving hemodialysis therapy, recent surgery for cecal cancer, and administration of esomeprazole...
August 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28803865/ureaplasma-urealyticum-necrotizing-soft-tissue-infection
#4
Ian Gassiep, Letitia Gore, Joanne L Dale, E Geoffrey Playford
Ureaplasma urealyticum is a urogenital commensal and often associated with localised infection. With the advent of monoclonal immunosuppressive therapy and improved diagnostic methods, reports of non-urogenital infections are accumulating. We report a rare case of U. urealyticum necrotizing soft tissue infection and left hip septic arthritis in a hypogammaglobulinaemic patient. Consideration of this organism as an etiological agent, and potential early use of nucleic-acid diagnostic investigation with empiric therapy including activity against Ureaplasma in this patient population may be warranted...
August 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28803864/the-detection-of-microorganisms-related-to-urethritis-from-the-oral-cavity-of-male-patients-with-urethritis
#5
Phuong Thi Le, Ryoichi Hamasuna, Masahiro Matsumoto, Keiichi Furubayashi, Masayuki Hatanaka, Shuichi Kawai, Takamasa Yamaguchi, Kazutaka Uehara, Norihiko Murakami, Masaru Yoshioka, Ken Nakayama, Yutaka Shiono, Keisuke Muraoka, Masahiko Suzuki, Naohiro Fujimoto, Tetsuro Matsumoto
OBJECTIVES: To investigate the presence of microorganisms related to urethritis in the oral cavity of male patients with urethritis and the efficacies of antimicrobials for urethritis on microorganisms in the oral cavity. METHODS: Ninety-two male patients with urethritis and 17 male controls participated to this study at 12 urology clinics in Japan between March 2014 and March 2015. The first voided urine (FVU) and oral wash fluid (OWF) specimens were collected from the participants...
August 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28781099/adverse-events-of-prophylactic-anti-influenza-agents-in-medical-staffs
#6
Hideo Kato, Mao Hagihara, Yukiko Kato, Ai Kurumiya, Tomoko Takahashi, Miki Sakata, Naoya Nishiyama, Nobuhiro Asai, Yusuke Koizumi, Tatsuro Furui, Yuka Yamagishi, Hiroshige Mikamo
BACKGROUND: We undertook a survey to evaluate the compliance and the tolerability of oseltamivir and zanamivir when they were used as post-exposure prophylaxis among the medical staffs in the 2014-2015 seasons to understand a characteristic of adverse events caused by anti-influenza (flu) agents. MATERIALS AND METHODS: During the study period, 540 medical staffs received oseltamivir (75 mg twice a day for 5 days) or zanamivir (twice a day for 5 days) as post-exposure prophylaxis of influenza, respectively...
August 3, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28779876/detection-of-streptococcus-agalactiae-by-immunochromatography-with-group-b-streptococcus-specific-surface-immunogenic-protein-in-pregnant-women
#7
Yoko Takayama, Hidehito Matsui, Yuzuru Adachi, Shin Nihonyanagi, Tatsuhiko Wada, Junko Mochizuki, Nobuya Unno, Hideaki Hanaki
BACKGROUND: Infection with Streptococcus agalactiae (Group B streptococcus: GBS) is a significant cause of morbidity and mortality in neonates. Screening for GBS is mainly done by culture-based methods, but a reliable result may take several days to obtain and culture is difficult to perform at institutions without a laboratory. We evaluated an immunochromatography method for rapid detection of GBS-specific surface immunogenic protein (Sip) using anti-Sip monoclonal antibodies. MATERIALS AND METHODS: A total of 377 cervical and vaginal swabs collected during weeks 35-37 of gestation were inoculated into GBS medium F and incubated...
August 2, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28751156/performance-evaluation-of-the-verigene-%C3%A2-clostridium-difficile-nucleic-acid-test-an-automated-multiplex-molecular-testing-system-for-detection-of-c-%C3%A2-difficile-toxin
#8
Kosuke Kosai, Yuki Iwanaga, Norihiko Akamatsu, Yuya Okada, Norihito Kaku, Naoki Uno, Yoshitomo Morinaga, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
The Verigene(®)Clostridium difficile nucleic acid test (Verigene(®) CDF test) is an automatic and rapid detection system for the genes encoding tcdA, tcdB, binary toxin, and the single nucleotide deletion at base pair 117 in the tcdC based on microarray and PCR amplification. We compared the performance of the Verigene(®) CDF test to that of two enzyme immunoassays, C. DIFF QUIK CHEK COMPLETE and X/Pect Toxin A/B, using 118 specimens. We found overall concordance rates of 81.4% and 78.8% between C. DIFF QUIK CHEK COMPLETE and Verigene(®) CDF test, and X/Pect Toxin A/B and Verigene(®) CDF test...
July 24, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28751155/primary-lung-abscess-caused-by-staphylococcus-lugdunensis
#9
Deng-Wei Chou, Chao-Tai Lee
Staphylococcus lugdunensis, a strain of coagulase-negative staphylococci, is part of the normal flora of human skin but can cause multiple infections at various sites. This microorganism has emerged as a major human pathogen. However, no study has reported primary lung abscess caused by S. lugdunensis. A 54-year-old alcoholic man without relevant past medical history was admitted because of primary lung abscesses. Empirical amoxicillin/clavulanate therapy was initially administered; however, the patient had persistent pleuritic chest pain and fever...
July 24, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28751154/the-etiology-and-bacteriology-of-healthcare-associated-empyema-are-quite-different-from-those-of-community-acquired-empyema
#10
Nobuhiro Asai, Hiroyuki Suematsu, Mao Hagihara, Naoya Nishiyama, Hideo Kato, Daisuke Sakanashi, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
OBJECTS: Changes in patients' background and life environment could contribute to increase healthcare-associated (HCA) empyema. There are no guidelines and statements for HCA empyema. METHODS: We retrospectively reviewed all patients with empyema who were admitted to the Aichi Medical University Hospital, Japan between 2008 and 2015. We evaluated patients' characteristics, microbial profiles, treatment and outcomes, and analyzed prognostic factors for 90-day mortality...
July 24, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28743428/a-therapeutic-benefit-of-daptomycin-against-glycopeptide-resistant-gram-positive-cocci-bloodstream-infections-under-neutropenia
#11
Kensuke Matsuda, Junji Koya, Kazuhiro Toyama, Mahoko Ikeda, Shunya Arai, Fumihiko Nakamura, Shu Okugawa, Kyoji Moriya, Mineo Kurokawa
Antibiotic-resistant infections remain to be a major issue for all over the world. Although appropriate diagnosis and rapid treatment initiation are crucially important particularly in immunocompromised patients, selection of antibiotics without identification of causative bacteria is often challenging. A 44-year-old woman with acute myeloid leukemia (AML) under myelosuppression suffered from teicoplanin-resistant gram-positive cocci bacteremia. Taking severe neutropenia due to chemotherapy and glycopeptide-resistance into account, teicoplanin was empirically substituted with daptomycin, which led to prompt defervescence...
July 22, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28729050/an-infant-with-concurrent-serotype-6c-invasive-pneumococcal-disease-and-infectious-mononucleosis
#12
Naoko Nishikawa-Nakamura, Takafumi Okada, Keiko Nishimura, Tsuyako Iwai, Kimiko Ubukata, Satoshi Iwata, Asayuki Iwai
Streptococcus pneumoniae is a main causative agent of serious invasive bacterial infections. However, concurrent infection with invasive pneumococcal disease (IPD) and viral infectious mononucleosis (IM) is rare. We report an infant with serotype 6C infection causing IPD occurring simultaneously with IM. A previously healthy 11-month-old girl referred to our hospital because of fever, leukopenia, and elevated C-reactive protein presented to us with disturbance of consciousness, tachycardia, tachypnea and agranulocytosis...
July 17, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28673558/characterization-of-first-hemin-requiring-pseudomonas-aeruginosa-small-colony-variants-from-the-blood-of-an-octogenarian-male-patient-with-double-pneumonitis
#13
Natsumi Nagano, Hideo Nakaya, Megumi Nagata, Toru Nishizawa, Ryuji Kawahara, Takehisa Matsumoto, Kozue Oana, Yoshiyuki Kawakami
A hemin-requiring Pseudomonas aeruginosa small-colony variant (SCV) was isolated from the blood of an octogenarian male-patient with double pneumonitis. The isolate was capable of growing on both sheep blood and chocolate agars but not on MacConkey agars without blood ingredient. Furthermore, the isolate revealed to grow only around the X-factor impregnated discs when examined using the X and V disc strips. However, not only RapID-NH system but also the VITEK2 system failed to identify the isolate. The isolate was finally identified as P...
June 30, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28655502/genetic-diversity-of-pvl-positive-community-onset-methicillin-resistant-staphylococcus-aureus-isolated-at-a-university-hospital-in-japan
#14
Hidemasa Nakaminami, Ayumu Ito, Daisuke Sakanashi, Hiroyuki Suematsu, Yuka Yamagishi, Hiroshige Mikamo, Norihisa Noguchi
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is pathogenic to healthy individuals and a significant issue throughout the world. Panton-Valentine leukocidin gene (pvl)-positive sequence type (ST) 8-staphylococcal cassette chromosome (SCC) mec type IV (ST8-IV) as represented by the USA300 clone, is the most prevalent CA-MRSA in many countries. However, the prevalence of pvl-positive CA-MRSA was limited in Japan. Here, we report the incidence of pvl-positive community-onset MRSA (CO-MRSA) isolated from 10 patients seen between 2009 and 2014 at a Japanese university hospital...
June 24, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28623110/pertussis-without-apparent-cough-in-a-disabled-girl-with-a-tracheostomy
#15
Hisataka Nozawa, Kensuke Shoji, Kazuhiro Uda, Tomoo Nakamura, Mitsuru Kubota, Akira Ishiguro, Isao Miyairi
Pertussis is characterized by intense, prolonged coughing in children often followed by a distinctive whooping sound on inspiration. However, the clinical manifestations and natural course of pertussis in disabled children are largely unknown. We experienced a case of pertussis in a disabled girl who had previously undergone a tracheostomy and laryngotracheal separation. She presented with increased tracheal secretions and required hospitalization but did not develop a cough. Pertussis was suspected from the sputum Gram stain, which revealed numerous, short gram-negative rods that did not grow on chocolate agar...
June 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28619239/antimicrobial-susceptibility-of-haemophilus-influenzae-strains-isolated-from-the-urethra-of-men-with-acute-urethritis-and-or-epididymitis
#16
Takashi Deguchi, Shin Ito, Kyoko Hatazaki, Kengo Horie, Mitsuru Yasuda, Keita Nakane, Kosuke Mizutani, Tomohiro Tsuchiya, Shigeaki Yokoi, Nozomu Hanaoka, Ken Shimuta, Makoto Ohnishi, Tetsuro Muratani, Masahiro Nakano
We determined minimum inhibitory concentrations (MICs) of 41 antimicrobial agents for 73 clinical strains of Haemophilusinfluenzae isolated from the urethra of men with acute urethritis and/or epididymitis and examined the strains for the production of β-lactamase. We also compared their antimicrobial susceptibilities with those of H. influenzae strains from respiratory tract or otorhinolaryngological infections that were reported in Japan. The proportion of β-lactamase-nonproducing ampicillin-resistant strains from acute urethritis and/or epididymitis appeared to be lower, but that of β-lactamase-producing ampicillin-resistant strains appeared to be higher, compared with those from respiratory tract or otorhinolaryngological infections...
June 12, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28552322/prevalence-of-skin-infections-caused-by-panton-valentine-leukocidin-positive-methicillin-resistant-staphylococcus-aureus%C3%A2-in%C3%A2-japan-particularly-in-ishigaki-okinawa
#17
Shunsuke Takadama, Hidemasa Nakaminami, Sae Aoki, Megumi Akashi, Takeaki Wajima, Masami Ikeda, Atsushi Mochida, Fumiko Shimoe, Kumiko Kimura, Yasushi Matsuzaki, Daisuke Sawamura, Yoichi Inaba, Tomohiro Oishi, Osamu Nemoto, Naoko Baba, Norihisa Noguchi
The prevalence of Panton-Valentine leukocidin gene (pvl)-positive community-acquired methicillin-resistant Staphylococcus aureus USA300 clone, which is designated as the ST8-staphylococcal cassette chromosome (SCC) mec type IV (ST8-IV) lineage, is a major public health concern worldwide. Thus, to elucidate the prevalence and characteristics of pvl-positive community-onset MRSA in Japan, we conducted a molecular epidemiological analysis for 854 S. aureus isolates obtained from outpatients with skin infections during 2013 and 2014...
May 25, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28545936/atypical-presentations-of-mers-cov-infection-in-immunocompromised-hosts
#18
Si-Ho Kim, Jae-Hoon Ko, Ga Eun Park, Sun Young Cho, Young Eun Ha, Ji-Man Kang, Yae-Jean Kim, Hee Jae Huh, Chang-Seok Ki, Byeong-Ho Jeong, Jinkyeong Park, Jun Ho Jang, Won Seog Kim, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Kyong Ran Peck
During the 2015 Korean MERS outbreak, we experienced atypical presentations of MERS-CoV infections in three immunocompromised hosts that warranted exceptional management. Case 1 showed delayed symptom development after a four-day asymptomatic period, Case 2 experienced a 20-day incubation period, and Case 3 exhibited persistent viral shedding without clinical deterioration. Recognizing these exceptions is extremely important in the management of MERS-CoV-exposed or -infected patients and for control of potential MERS outbreaks...
May 23, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28729052/tedizolid-inhibits-muc5ac-production-induced-by-methicillin-resistant-staphylococcus-aureus-in-human-airway-epithelial-cells
#19
Kazuaki Takeda, Norihito Kaku, Yoshitomo Morinaga, Kosuke Kosai, Naoki Uno, Yoshifumi Imamura, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
The innate immune system plays an important role in early immunity against respiratory tract infection. Although airway epithelial cells produce mucus to eliminate pathogens and irritants, hypersecretion of mucus is harmful for the host as it may cause airway obstruction and inhibit influx of antimicrobial agents. It has been reported that several antimicrobial agents have an immunomodulatory effect in vitro and in vivo, but little is known about whether tedizolid, a novel oxazolidinone, can modulate immune responses...
September 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28729051/inhibiting-effects-of-fructanase-on-competence-stimulating-peptide-dependent-quorum-sensing-system-in-streptococcus-mutans
#20
Yusuke Suzuki, Ryo Nagasawa, Hidenobu Senpuku
Streptococcus mutans produces glucosyltransferases encoded by the gtfB and gtfC genes, which synthesize insoluble glucan, and both insoluble and soluble glucans by conversion of sucrose, and are known as principal agents to provide strong biofilm formation and demineralization on tooth surfaces. S. mutans possess a Com-dependent quorum sensing (QS) system, which is important for survival in severe conditions. The QS system is stimulated by the interaction between ComD {Receptor to competence-stimulating peptide (CSP)} encoded by the comD and CSP encoded by the comC, and importantly associated with bacteriocin production and genetic competence...
September 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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