Jiro Osaka, Haruka Yasuda, Yusuke Watanuki, Yuya Kato, Yohei Nitta, Atsushi Sugie, Makoto Sato, Takashi Suzuki
Neural activity-dependent synaptic plasticity is an important physiological phenomenon underlying environmental adaptation, memory and learning. However, its molecular basis, especially in presynaptic neurons, is not well understood. Previous studies have shown that the number of presynaptic active zones in the Drosophila melanogaster photoreceptor R8 is reversibly changed in an activity-dependent manner. During reversible synaptic changes, both synaptic disassembly and assembly processes were observed. Although we have established a paradigm for screening molecules involved in synaptic stability and several genes have been identified, genes involved in stimulus-dependent synaptic assembly are still elusive...
March 3, 2023: Genes & Genetic Systems