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Diabetes & Metabolism

M B Rehman, B V Tudrej, J Soustre, M Buisson, P Archambault, D Pouchain, H Vaillant-Roussel, F Gueyffier, J-L Faillie, M-C Perault-Pochat, C Cornu, R Boussageon
BACKGROUND: Guidelines for type 2 diabetes (T2D) recommend reducing HbA1c through lifestyle interventions and glucose-lowering drugs (metformin, then combination with dipeptidyl peptidase-4 inhibitors [DPP-4Is] among other glucose-lowering drugs). However, no double-blind randomized clinical trial (RCT) compared with placebo has so far demonstrated that DDP-4Is reduce micro- and macrovascular complications in T2D. Moreover, the safety of DPP-4Is (with increased heart failure and acute pancreatitis) remains controversial...
October 10, 2016: Diabetes & Metabolism
G Kim, Y-H Lee, J Y Jeon, H Bang, B-W Lee, E S Kang, I-K Lee, B-S Cha, C S Kim
OBJECTIVE: The association between resting heart rate (RHR) and the development of diabetes has yet to be fully elucidated, and the relationship between changes in RHR and incidence of diabetes also remains unclear. Our study aimed to investigate the association between changes in RHR over 2 years and the risk of diabetes. METHODS: A total of 7416 adults without diabetes were included. All had participated in the Korean Genome and Epidemiology Study, a community-based, 10-year prospective study in which RHR was measured at baseline and 2 years later...
October 10, 2016: Diabetes & Metabolism
A J Cox, P Zhang, D W Bowden, B Devereaux, P M Davoren, A W Cripps, N P West
AIM: Relationships between the intestinal microbiota, intestinal permeability and inflammation in the context of risk for obesity-associated disease continue to be of interest. The aim of the study was to examine the associations between intestinal permeability and type 2 diabetes (T2D). METHODS: A total of 130 individuals with T2D (age: 57.5±6.2 years (mean±SD); BMI: 30.4±3.2; 45% female) and 161 individuals without T2D (age: 37.4±12.5 years; BMI: 25.1±3.9; 65% female) were included in the study...
October 10, 2016: Diabetes & Metabolism
C Dunyach-Remy, C Courtais-Coulon, C DeMattei, N Jourdan, S Schuldiner, A Sultan, C Carrière, S Alonso, A Sotto, J-P Lavigne
AIMS: Nasal carriage of Staphylococcus aureus in diabetic patients may be a risk factor for diabetic foot lesion infections. The aims of this study were to compare the genotypic profiles of S. aureus strains isolated from nares and diabetic foot ulcers (DFUs) using microarray technology. METHODS: Patients were included if they were admitted for diabetic foot infection (DFI) at any of three diabetology departments of Montpellier and Nîmes University Hospitals between 1 September 2010 to 30 June 2012...
October 5, 2016: Diabetes & Metabolism
E Seelig, K Timper, C Falconnier, R Stoeckli, S Bilz, R Oram, T J McDonald, M Y Donath
No abstract text is available yet for this article.
October 5, 2016: Diabetes & Metabolism
K Fujihara, R Igarashi, M Yamamoto, M Ishizawa, Y Matsubayasi, S Matsunaga, K Kato, C Ito, M Koishi, N Yamanaka, S Kodama, H Sone
AIMS: To examine the impact of glucose tolerance status on the development of coronary artery disease (CAD) in working-age men in Japan. METHODS: This population-based retrospective cohort study included 111,621 men aged 31-60 years [63,558 with normal glucose tolerance (NGT); 37,126 with prediabetes; 10,937 with diabetes]. The Cox proportional-hazards regression model was used to identify variables related to the incidence of CAD. RESULTS: Multivariate analysis showed that, compared with NGT, diabetes increased the risk of CAD by 17...
October 3, 2016: Diabetes & Metabolism
M Buysschaert, C Tshongo Muhindo, O Alexopoulou, D Rahelic, H Reychler, V Preumont
No abstract text is available yet for this article.
September 28, 2016: Diabetes & Metabolism
C Vatier, L Arnaud, X Prieur, B Guyomarch, C Le May, E Bigot, M Pichelin, A Daguenel, M-C Vantyghem, J-F Gautier, C Vigouroux, B Cariou
No abstract text is available yet for this article.
September 27, 2016: Diabetes & Metabolism
T Osaka, Y Hashimoto, T Fukuda, M Tanaka, M Yamazaki, M Fukui
No abstract text is available yet for this article.
September 22, 2016: Diabetes & Metabolism
A Moutairou, R Roussel, B Charbonnel, R El Boustany, A Nicolas, A Leye, K Mohammedi, M Marre, B Detournay, L Potier
No abstract text is available yet for this article.
September 21, 2016: Diabetes & Metabolism
J-P Riveline, P Boudou, B Blondeau, J-F Gautier
No abstract text is available yet for this article.
September 21, 2016: Diabetes & Metabolism
Y-W Su, C-Y Hsu, Y-W Guo, H-S Chen
AIMS: To evaluate the correlation between the plasma glucose-to-glycated haemoglobin ratio (GAR) and clinical outcome during acute illness. METHODS: This retrospective observational cohort study enrolled 661 patients who visited the emergency department of our hospital between 1 July 2008 and 30 September 2010 with plasma glucose concentrations>500mg/dL. Systolic blood pressure, heart rate, white blood cells, neutrophils, haematocrit, blood urea nitrogen, serum creatinine, liver function and plasma glucose concentration were recorded at the initial presentation to the emergency department...
September 20, 2016: Diabetes & Metabolism
S Béliard, F Bonnet, B Bouhanick, E Bruckert, B Cariou, S Charrière, V Durlach, P Moulin, R Valéro, B Vergès
No abstract text is available yet for this article.
September 19, 2016: Diabetes & Metabolism
M Afarideh, S Noshad, A Ghajar, Z Aryan, E Khajeh, S Hosseini Shirvani, F Bonnet, A Esteghamati
No abstract text is available yet for this article.
September 16, 2016: Diabetes & Metabolism
S Lindberg, J S Jensen, M Bjerre, J Frystyk, A Flyvbjerg, J Jeppesen, R Mogelvang
AIM: Adiponectin is the most abundant adipokine and may play a key role in the interplay between obesity, inflammation, insulin resistance and the metabolic syndrome (MetS). Thus, this large population-based cohort investigated whether adiponectin at baseline and/or a decrease in adiponectin during follow-up is associated prospectively with the risk of incident MetS. METHODS: Using a prospective study design, the development of MetS was examined in 1134 healthy participants from the community...
September 14, 2016: Diabetes & Metabolism
S Tsukada, H Masuda, S Y Jung, J Yun, S Kang, D Y Kim, J H Park, S T Ji, S-M Kwon, T Asahara
AIM: Dysfunction of circulating endothelial progenitor cells (EPCs) has been shown to affect the development of microvascular diseases in diabetes patients. The aim of this study was to elucidate the development and mechanical dysfunction of EPCs in type 2 diabetes (T2D). METHODS: The colony-forming capacity of EPCs and differentiation potential of bone marrow (BM) c-Kit(+)/Sca-I(+) lineage-negative mononuclear cells (KSL) were examined in T2D mice, db/db mice and KKA(y) mice, using EPC colony-forming assay (EPC-CFA)...
September 13, 2016: Diabetes & Metabolism
F Jiao, C S C Fung, Y F Wan, S M McGhee, C K H Wong, D Dai, R Kwok, C L K Lam
AIM: To evaluate the effectiveness of the multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) in reducing the risks of microvascular complications. METHODS: This prospective cohort study was conducted with 29,670 propensity-score-matched RAMP-DM participants and diabetes patients under the usual primary care (14,835 in each group). Study endpoints were the first occurrence of any diabetic microvascular complications, non-proliferative diabetic retinopathy/preproliferative diabetic retinopathy (NPDR/prePDR), sight-threatening diabetic retinopathy (STDR) or blindness, nephropathy, end-stage renal disease (ESRD), neuropathy and lower-limb ulcers or amputation...
August 24, 2016: Diabetes & Metabolism
F Maillard, S Rousset, B Pereira, A Traore, P de Pradel Del Amaze, Y Boirie, M Duclos, N Boisseau
AIM: This study compared the effect of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) for 16 weeks on whole-body and abdominal fat mass (FM) in postmenopausal women with type 2 diabetes (T2D). METHODS: Seventeen women (69±1 years; BMI: 31±1kg.m(-2)) were randomly assigned to either a HIIT [60×(8s at 77-85% HRmax, 12s of active recovery)] or MICT (40min at 55-60% of their individual HRR) cycling program for 16 weeks, 2 days/week...
August 23, 2016: Diabetes & Metabolism
A Zielińska, R Maciulewski, K Siewko, A Popławska-Kita, D Lipińska, G Kozłowska, M Górska, M Szelachowska
AIM: Evidence in support of an association between betatrophin and insulin resistance (IR) is mounting, with studies demonstrating that betatrophin is elevated in patients with type 2 diabetes, obesity and gestational diabetes. The aim of this study was to evaluate the role of betatrophin in IR and physiological proliferation of beta cells during pregnancy in healthy women. METHODS: Eighty healthy pregnant women were examined at each trimester [T1 (first), T2 (second), T3 (third)], with a subgroup (n=45) that was also examined at 3 months postpartum (3MPP)...
August 20, 2016: Diabetes & Metabolism
J-C Chauvet-Gélinier, B Trojak, C Lemogne, A Louprou, B Bouillet, I Simoneau, K Chahraoui, J-M Petit, S M Consoli, B Bonin, B Vergès
No abstract text is available yet for this article.
August 5, 2016: Diabetes & Metabolism
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