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Diabetes & Metabolism

M Buysschaert, B Buysschaert, J Jamart
No abstract text is available yet for this article.
June 14, 2018: Diabetes & Metabolism
A Sattarinezhad, J Roozbeh, B Shirazi Yeganeh, G R Omrani, M Shams
AIM: Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN. METHODS: In this randomized, double-blind, placebo-controlled clinical trial, 60 patients with type 2 diabetes and albuminuria were randomly assigned to receive either resveratrol (500mg/day) or placebo for 90 days. Losartan (12.5mg/day) was also administered to all participants...
June 8, 2018: Diabetes & Metabolism
Y Du, J Baumert, R Paprott, H Neuhauser, C Heidemann, C Scheidt-Nave
No abstract text is available yet for this article.
June 8, 2018: Diabetes & Metabolism
L Marchand, S Reffet, J Vouillarmet, C Cugnet-Anceau, E Disse, C Thivolet
No abstract text is available yet for this article.
June 6, 2018: Diabetes & Metabolism
K S Weber, K Straßburger, M Fritsch, A Bierwagen, C Koliaki, E Phielix, G Pacini, J-H Hwang, D F Markgraf, V Burkart, K Müssig, J Szendroedi, M Roden
AIM: Type 2 diabetes (T2D) alters glucagon, glucagon-like peptide (GLP)-1, glucose-dependent insulinotropic polypeptide (GIP) and hepatic energy metabolism, yet the possible relationships remain unclear. METHODS: In this observational study, lean insulin-sensitive control subjects (BMI: 23.2±1.5kg/m2 ), age-matched insulin-resistant obese subjects (BMI: 34.3±1.7kg/m2 ) and similarly obese elderly T2D patients (BMI: 32.0±2.4kg/m2 ) underwent mixed-meal tolerance tests (MMTTs), and assessment of hepatic γATP, inorganic phosphate (Pi ) and lipids using 31 P/1 H magnetic resonance spectroscopy...
June 2, 2018: Diabetes & Metabolism
E S Scott, R T McGrath, A S Januszewski, G R Fulcher, A J Jenkins
No abstract text is available yet for this article.
May 29, 2018: Diabetes & Metabolism
M D Garcia de Lucas, L M Pérez Belmonte, M Suárez Tembra, J Olalla Sierra, R Gómez Huelgas
AIM: To analyze the efficacy and safety of replacing sitagliptin with canagliflozin in patients with type 2 diabetes (T2D) and poor metabolic control despite treatment with sitagliptin in combination with metformin and/or gliclazide. MATERIALS AND METHODS: In this multicentre observational, retrospective, 26-week clinical study of patients with T2D and poor glycaemic control (HbA1c: 7.5-9.5%) treated with sitagliptin in combination with metformin and/or gliclazide, sitagliptin (and gliclazide if appropriate) were replaced by canagliflozin...
May 22, 2018: Diabetes & Metabolism
B G Kral, D M Becker, L R Yanek, D Vaidya, R A Mathias, L C Becker, R R Kalyani
AIM: Type 2 diabetes (T2DM) in a first-degree relative is a risk factor for incident diabetes. Americans of African ancestry (AA) have higher rates of T2DM than Americans of European ancestry (EA). Thus, we aimed to determine whether the presence, number and kinship of affected relatives are associated with race-specific T2DM incidence in a prospective study of participants from the Genetic Study of Atherosclerosis Risk (GeneSTAR), who underwent baseline screening including a detailed family history...
May 21, 2018: Diabetes & Metabolism
J Doucet, C Verny, B Balkau, A J Scheen, B Bauduceau
AIM: The role of glycaemic control in the mortality of elderly diabetic patients remains uncertain. GERODIAB is the first multi-centre, prospective, observational study that aims to describe the link between HbA1c and 5-year mortality in French, type 2 diabetic patients aged ≥70 years. METHODS: Consecutive patients (n=987; mean age 77 years) were included from 56 diabetes centres and followed for five years. Individual histories, risk factors, standard diabetes parameters and geriatric evaluations were regularly recorded...
May 18, 2018: Diabetes & Metabolism
B Rasouli, E Ahlqvist, L Alfredsson, T Andersson, P-O Carlsson, L Groop, J E Löfvenborg, M Martinell, A Rosengren, T Tuomi, A Wolk, S Carlsson
AIM: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. METHODS: This population-based study comprised incident cases of LADA (n=484) and T2D (n=1609), and also 885 healthy controls...
May 17, 2018: Diabetes & Metabolism
C-H Tseng
PURPOSE: This study aimed to investigate whether metformin can affect risk of chronic obstructive pulmonary disease (COPD) in type 2 diabetes (T2D) patients. METHODS: T2D patients newly diagnosed during 1999-2005 were enrolled from the reimbursement database of Taiwan's National Health Insurance system and followed up to 31 December 2011. Analyses were conducted in an unmatched cohort (92,272 ever-users and 10,697 never-users of metformin) and a propensity score (PS) matched pair cohort (10,697 ever-users and 10,697 never-users)...
May 17, 2018: Diabetes & Metabolism
H B Østergaard, T Mandrup-Poulsen, G F N Berkelmans, Y van der Graaf, F L J Visseren, J Westerink
BACKGROUND: The haemoglobin glycation index (HGI) has been proposed as a marker of interindividual differences in haemoglobin glycosylation. Previous studies have shown a relationship between high HGI and risk of cardiovascular disease (CVD) in patients with diabetes. However, no studies have investigated the role of previous CVD in this association. METHODS: The study cohort comprised patients with type 2 diabetes mellitus (T2DM; n=1910) included in the Second Manifestations of Arterial Disease (SMART) study...
May 8, 2018: Diabetes & Metabolism
J Lepercq, C Le Ray, C Godefroy, L Pelage, D Dubois-Laforgue, J Timsit
AIM: This study assessed pregnancy outcomes in women with type 1 diabetes (T1D) over the last 15 years and identified modifiable factors associated with good perinatal outcomes. METHODS: Pregnancy outcomes were prospectively assessed in this cohort study of 588 singleton pregnancies (441 women) managed by standardized care from 2000 to 2014. A good perinatal outcome was defined as the uncomplicated delivery of a normally formed, non-macrosomic, full-term infant with no neonatal morbidity...
May 8, 2018: Diabetes & Metabolism
V Ponzo, L Gentile, R Gambino, R Rosato, I Cioffi, N Pellegrini, A Benso, F Broglio, M Cassader, S Bo
No abstract text is available yet for this article.
May 8, 2018: Diabetes & Metabolism
A L Le Lepvrier, F Leysour de Rohello, V Brunel, G Prevost
No abstract text is available yet for this article.
May 4, 2018: Diabetes & Metabolism
H Kahal, A Aburima, B Spurgeon, K S Wraith, A S Rigby, T Sathyapalan, E S Kilpatrick, K M Naseem, S L Atkin
AIM: Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24hours following induced hypoglycaemia in people with type 2 diabetes compared to healthy age-matched controls. METHODS: Hyperinsulinaemic clamps reduced blood glucose to 2.8mmol/L (50mg/dl) for 1hour. Sampling at baseline; euglycaemia 5mmol/L (90mg/dl); hypoglycaemia; and at 24 post clamp were undertaken...
May 3, 2018: Diabetes & Metabolism
A Quintal, V Messier, R Rabasa-Lhoret, E Racine
The artificial pancreas combines a hormone infusion pump with a continuous glucose monitoring device, supported by a dosing algorithm currently installed on the pump. It allows for dynamic infusions of insulin (and possibly other hormones such as glucagon) tailored to patient needs. For patients with type 1 diabetes the artificial pancreas has been shown to prevent more effectively hypoglycaemic events and hyperglycaemia than insulin pump therapy and has the potential to simplify care. However, the potential ethical issues associated with the upcoming integration of the artificial pancreas into clinical practice have not yet been discussed...
April 25, 2018: Diabetes & Metabolism
X-Q Li, D-Y Chang, M Chen, M-H Zhao
AIM: Emerging evidence has indicated a role of the complement system in the pathogenesis of diabetic nephropathy (DN), although the pathways of complement activation and their clinicopathological relevance in DN are as yet unclear. The present study aimed to investigate levels of various complement components in plasma and urine of DN patients, and their correlation with clinicopathological parameters. METHODS: A total of 68 biopsy-proven DN patients with plasma samples were recruited, including 50 patients who also had urine samples available...
April 16, 2018: Diabetes & Metabolism
E Sánchez, A Lecube, À Betriu, C Hernández, C López-Cano, L Gutiérrez-Carrasquilla, M Kerkeni, A Yeramian, F Purroy, R Pamplona, C Farràs, E Fernández, F Barbé, R Simó, M Hernández, F Rius, D Polanco, M S de la Torre, G Torres, P Godoy, M Portero-Otin, M Jové, L Colàs-Compàs, I Benabdelhak, E Miquel, M Ortega, J M Valdivielso, M Bermúdez, M Martínez-Alonso
No abstract text is available yet for this article.
April 13, 2018: Diabetes & Metabolism
B Balkau, M Metzger, F Andreelli, L Frimat, E Speyer, C Combe, M Laville, C Jacquelinet, S Briançon, C Ayav, Z Massy, R L Pisoni, B Stengel, D Fouque
AIM: To describe current practices of glucose-lowering treatments in people with diabetes and chronic kidney disease (CKD), the associated glucose control and hypoglycaemic symptoms, with an emphasis on sex differences. METHODS: Among the 3033 patients with CKD stages 3-5 recruited into the French CKD-REIN study, 645 men and 288 women had type 2 diabetes and were treated by glucose-lowering drugs. RESULTS: Overall, 31% were treated only with insulin, 28% with combinations of insulin and another drug, 42% with non-insulin glucose-lowering drugs...
April 6, 2018: Diabetes & Metabolism
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