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Diabetes & Metabolism

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https://www.readbyqxmd.com/read/28438547/metformin-is-associated-with-a-lower-risk-of-colorectal-cancer-in-taiwanese-patients-with-type-2-diabetes-a-retrospective-cohort-analysis
#1
C-H Tseng
BACKGROUND: The association between metformin and colorectal cancer (CRC) has rarely been investigated in Asian populations. METHODS: This retrospective cohort study included patients with newly diagnosed type 2 diabetes during 1999-2005, recruited from Taiwan's National Health Insurance database. A total of 169,601 patients (original cohort: 153,270 ever-users and 16,331 never-users of metformin) and a subgroup of 1:1 propensity-score-matched pairs of 16,331 ever-users and 16,331 never-users (matched cohort) were followed up to 31 December 2011...
April 21, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28433560/glycaemic-control-and-hypoglycaemia-with-insulin-glargine-300-u-ml-compared-with-glargine-100-u-ml-in-japanese-adults-with-type-2-diabetes-using-basal-insulin-plus-oral-anti-hyperglycaemic-drugs-edition-jp-2-randomised-12-month-trial-including-6-month-extension
#2
Y Terauchi, M Koyama, X Cheng, M Sumi, M C Riddle, G B Bolli, T Hirose
AIMS: To compare insulin glargine 300 U/mL (Gla-300) with glargine 100 U/mL (Gla-100) in Japanese adults with uncontrolled type 2 diabetes on basal insulin and oral anti-hyperglycaemic drugs over 12 months. METHODS: EDITION JP 2 was a randomised, open-label, phase 3 study. Following a 6-month treatment period, participants continued receiving previously assigned once daily Gla-300 or Gla-100, plus oral anti-hyperglycaemic drugs, in a 6-month extension period. Glycaemic control, hypoglycaemia and adverse events were assessed...
April 19, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28392167/associations-between-a-fetal-imprinted-gene-allele-score-and-late-pregnancy-maternal-glucose-concentrations
#3
C J Petry, K Mooslehner, P Prentice, M G Hayes, M Nodzenski, D M Scholtens, I A Hughes, C L Acerini, K K Ong, W L Lowe, D B Dunger
AIM: We hypothesised that some of the genetic risk for gestational diabetes (GDM) is due to the fetal genome affecting maternal glucose concentrations. Previously, we found associations between fetal IGF2 gene variants and maternal glucose concentrations in late pregnancy. METHODS: In the present study, we tested associations between SNP alleles from 15 fetal imprinted genes and maternal glucose concentrations in late pregnancy in the Cambridge Baby Growth and Wellbeing cohorts (1160 DNA trios)...
April 6, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28389064/importance-of-alternative-site-blood-glucose-testing-in-the-diagnosis-of-artifactual-hypoglycaemia-in-systemic-scleroderma
#4
LETTER
V Dubourdieu, H Mosbah, C Amouyal, A Hartemann, F Andreelli
No abstract text is available yet for this article.
April 4, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28365211/a-parental-history-of-diabetes-is-associated-with-a-high-risk-of-retinopathy-in-patients-with-type-2-diabetes
#5
LETTER
G Lapeyre, A Cougnard-Grégoire, M-N Delyfer, C Delcourt, S Hadjadj, L Blanco, E Pupier, M-B Rougier, K Rajaobelina, K Mohammedi, M Hugo, J F Korobelnik, V Rigalleau
No abstract text is available yet for this article.
March 29, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28347654/efficacy-and-safety-of-alirocumab-in-insulin-treated-patients-with-type-1-or-type-2-diabetes-and-high-cardiovascular-risk-rationale-and-design-of-the-odyssey-dm-insulin-trial
#6
B Cariou, L A Leiter, D Müller-Wieland, G Bigot, H M Colhoun, S Del Prato, R R Henry, F J Tinahones, A Letierce, L Aurand, J Maroni, K K Ray, M Bujas-Bobanovic
AIMS: The coadministration of alirocumab, a PCSK9 inhibitor for treatment of hypercholesterolaemia, and insulin in diabetes mellitus (DM) requires further study. Described here is the rationale behind a phase-IIIb study designed to characterize the efficacy and safety of alirocumab in insulin-treated patients with type 1 (T1) or type 2 (T2) DM with hypercholesterolaemia and high cardiovascular (CV) risk. METHODS: ODYSSEY DM-INSULIN (NCT02585778) is a randomized, double-blind, placebo-controlled, multicentre study that planned to enrol around 400 T2 and up to 100 T1 insulin-treated DM patients...
March 24, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28325589/all-cause-mortality-in-patients-with-diabetes-under-glucagon-like-peptide-1-agonists-a-population-based-open-cohort-study
#7
K A Toulis, W Hanif, P Saravanan, B H Willis, T Marshall, B Kumarendran, K Gokhale, S Ghosh, K K Cheng, P Narendran, G N Thomas, K Nirantharakumar
AIM: The glucagon-like peptide-1 receptor agonist (GLP1a) liraglutide has been described to benefit patients with type 2 diabetes mellitus (T2DM) at high cardiovascular risk. However, there are still uncertainties relating to these cardiovascular benefits: whether they also apply to an unselected diabetic population that includes low-risk patients, represent a class-effect, and could be observed in a real-world setting. METHODS: We conducted a population-based, retrospective open cohort study using data derived from The Health Improvement Network database between Jan 2008 to Sept 2015...
March 18, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28318913/characteristics-and-predictors-of-obstructive-sleep-apnoea-in-patients-with-type-2-diabetes
#8
LETTER
M José M C Souza, A Kelley L Medeiros, M M B Carvalho, C A Medeiros, T C Lustosa, T Leiane Guerra de Couto, R R M Silva, M A B B Correia, R A P Oliveira, M V F P Silva, I V Secundo, R P Pedrosa
No abstract text is available yet for this article.
March 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28318912/less-liver-fibrosis-in-metabolically-healthy-compared-with-metabolically-unhealthy-obese-patients-with-non-alcoholic-fatty-liver-disease
#9
Y Gutiérrez-Grobe, E Juárez-Hernández, B A Sánchez-Jiménez, M H Uribe-Ramos, M H Ramos-Ostos, M Uribe, N C Chávez-Tapia
AIM: This cross-sectional study evaluated liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), and compared the characteristics of metabolically healthy obese (MHO) with metabolically unhealthy obese (MUHO) patients. METHODS: The study was nested within a randomized clinical trial (RCT) and included obese patients with NAFLD, as determined by liver ultrasonography. Fibrosis was assessed by transient elastography, and AST-to-platelet ratio index (APRI) and NAFLD score...
March 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28314670/diabetes-remission-after-bariatric-surgery-in-obese-patients-with-haemochromatosis
#10
LETTER
F Phan, C Vatier, C Vauloup-Soupault, C Poitou, J-L Bouillot, J-M Oppert, J Aron-Wisnewsky
No abstract text is available yet for this article.
March 14, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28283288/increase-in-cortisol-acth-ratio-after-chronic-treatment-with-liraglutide-in-patients-with-type-2-diabetes
#11
LETTER
S Kamei, H Kaneto, A Tanabe, T Kinoshita, A Obata, T Kimura, H Hirukawa, F Tatsumi, M Shimoda, K Kohara, Takatoshi Anno, S Nakanishi, T Mune, K Kaku
No abstract text is available yet for this article.
March 7, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28279650/hyperglycaemia-within-the-first-month-after-allogeneic-haematopoietic-stem-cell-transplantation-is-an-independent-risk-factor-for-overall-survival-in-patients-with-acute-myeloid-leukaemia
#12
LETTER
F Aberer, S Kremser, J K Mader, W Zinke-Cerwenka, H Greinix, N J Tripolt, T R Pieber, A Zebisch, H Sill, A Oulhaj, H Sourij, A Wölfler
No abstract text is available yet for this article.
March 6, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28259539/oxidative-and-energetic-stresses-mediate-beta-cell-dysfunction-induced-by-pgc-1%C3%AE
#13
A Besseiche, J-P Riveline, L Delavallée, F Foufelle, J-F Gautier, B Blondeau
AIM: Alteration of functional beta-cell mass in adults can be programmed by adverse events during fetal life. Previously, it was demonstrated that high glucocorticoid (GC) levels during fetal life participate in this programming by inhibition of beta-cell development. More specifically, GC levels stimulate expression of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α), a transcriptional co-regulator of the GC receptor (GR), which per se impairs beta-cell mass and function when overexpressed...
March 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28259538/association-between-diabetes-and-changes-in-hearing-a-cross-sectional-study
#14
LETTER
S Lebech Cichosz, O Hejlesen
No abstract text is available yet for this article.
March 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28238600/moderate-intensity-sports-and-exercise-is-associated-with-glycaemic-control-in-women-with-gestational-diabetes
#15
S F Ehrlich, M M Hedderson, S D Brown, B Sternfeld, L Chasan-Taber, J Feng, J Adams, J Ching, Y Crites, C P Quesenberry, A Ferrara
AIM: To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women with gestational diabetes (GDM). METHODS: Prospective cohort study of 971 women who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionnaire assessing moderate and vigorous intensity sports and exercise in the past 3 months. Self-monitored capillary glucose values were obtained for the 6-week period following the questionnaire, with optimal glycaemic control defined≥80% values meeting the targets<5...
February 23, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28236571/multicentre-randomized-controlled-trial-with-sensor-augmented-pump-vs-multiple-daily-injections-in-hospitalized-patients-with-type-2-diabetes-in-china-time-to-reach-target-glucose
#16
W Gu, Y Liu, Y Chen, W Deng, X Ran, L Chen, D Zhu, J Yang, J Shin, S W Lee, T L Cordero, Y Mu
AIM: Sensor-augmented pump (SAP) technology, which combines continuous subcutaneous insulin infusion (CSII) and real-time continuous glucose monitoring (RT-CGM), has been available for several years in China. In this study, the time required to reach predefined glycaemic targets with SAP vs multiple daily injection (MDI) therapy was compared in hospitalized patients with type 2 diabetes mellitus (T2DM). METHODS: Adults (aged 18-65 years) with T2DM treated with insulin and admitted to hospital for glucose management were randomized to either SAP (Medtronic MiniMed™ Paradigm™ 722 system) or MDI with blinded CGM (Medtronic MiniMed CGMS System Gold™) for a 2-week period...
February 21, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28214129/the-novel-adipokine-hepatokine-fetuin-b-in-severe-human-and-murine-diabetic-kidney-disease
#17
LETTER
S Kralisch, A Hoffmann, N Klöting, A Bachmann, J Kratzsch, M Blüher, M-Z Zhang, R C Harris, M Stumvoll, M Fasshauer, T Ebert
No abstract text is available yet for this article.
February 14, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28190592/maternal-and-paternal-family-history-of-diabetes-in-second-degree-relatives-and-metabolic-outcomes-at-age-5-6-years-the-abcd-study
#18
A J J M Oostvogels, C P Landstra, L Britsemmer, R Lodewijkx, K Stronks, T J Roseboom, T G M Vrijkotte
AIM: To investigate whether children with a family history of diabetes (FHD) in second-degree relatives (grandparents, aunts/uncles) are at increased risk of developing obesity and diabetes, and whether the risk differs between maternal or paternal transmission. METHODS: In the multiethnic population-based cohort Amsterdam-Born Children and Their Development (ABCD) Study, body mass index (BMI), waist-to-height ratio (WHR), fat percentage (fat%), fasting glucose and C-peptide in 5- or 6-year-old children with no second-degree FHD (n=2226) were compared with children with maternal-only (n=353), paternal-only (n=281) or both maternal and paternal (n=164) second-degree FHD...
February 10, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28162956/exercise-and-ectopic-fat-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#19
REVIEW
A Sabag, K L Way, S E Keating, R N Sultana, H T O'Connor, M K Baker, V H Chuter, J George, N A Johnson
Ectopic adipose tissue surrounding the intra-abdominal organs (visceral fat) and located in the liver, heart, pancreas and muscle, is linked to cardio-metabolic complications commonly experienced in type 2 diabetes. A systematic review and meta-analysis was performed to determine the effect of exercise on ectopic fat in adults with type 2 diabetes. Relevant databases were searched to February 2016. Included were randomised controlled studies, which implemented≥4 weeks of aerobic and/or resistance exercise and quantified ectopic fat via magnetic resonance imaging, computed tomography, proton magnetic resonance spectroscopy or muscle biopsy before and after intervention...
February 2, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161372/successful-endoscopic-ultrasound-guided-ethanol-ablation-of-a-symptomatic-sporadic-insulinoma-in-a-patient-with-severe-comorbidities-not-suitable-for-pancreatic-surgery
#20
LETTER
K Burghardt, D Kaemmerer, A Michael, R Aschenbach, U A Müller, C Kloos, G Wolf
No abstract text is available yet for this article.
February 1, 2017: Diabetes & Metabolism
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