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Diabetes & Metabolism

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https://www.readbyqxmd.com/read/28214129/the-novel-adipokine-hepatokine-fetuin-b-in-severe-human-and-murine-diabetic-kidney-disease
#1
LETTER
S Kralisch, A Hoffmann, N Klöting, A Bachmann, J Kratzsch, M Blüher, M-Z Zhang, R C Harris, M Stumvoll, M Fasshauer, T Ebert
No abstract text is available yet for this article.
February 14, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28190592/maternal-and-paternal-family-history-of-diabetes-in-second-degree-relatives-and-metabolic-outcomes-at-age-5-6-years-the-abcd-study
#2
A J J M Oostvogels, C P Landstra, L Britsemmer, R Lodewijkx, K Stronks, T J Roseboom, T G M Vrijkotte
AIM: To investigate whether children with a family history of diabetes (FHD) in second-degree relatives (grandparents, aunts/uncles) are at increased risk of developing obesity and diabetes, and whether the risk differs between maternal or paternal transmission. METHODS: In the multiethnic population-based cohort Amsterdam-Born Children and Their Development (ABCD) Study, body mass index (BMI), waist-to-height ratio (WHR), fat percentage (fat%), fasting glucose and C-peptide in 5- or 6-year-old children with no second-degree FHD (n=2226) were compared with children with maternal-only (n=353), paternal-only (n=281) or both maternal and paternal (n=164) second-degree FHD...
February 10, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28169086/basal-insulin-treatment-intensification-in-patients-with-type-2-diabetes-mellitus-a-comprehensive-systematic-review-of-current-options
#3
REVIEW
D Raccah
AIM: As type 2 diabetes mellitus progresses, most patients require treatment with basal insulin in combination with another agent to achieve recommended glycaemic targets. The purpose of this systematic review was to examine the evidence supporting the use of the available add-on treatments [rapid-acting insulin (RAI), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), dipeptidyl peptidase (DPP)-4 inhibitors and sodium-glucose cotransporter-2 (SGLT-2) inhibitors] to basal insulin...
February 3, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28162956/exercise-and-ectopic-fat-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#4
REVIEW
A Sabag, K L Way, S E Keating, R N Sultana, H T O'Connor, M K Baker, V H Chuter, J George, N A Johnson
Ectopic adipose tissue surrounding the intra-abdominal organs (visceral fat) and located in the liver, heart, pancreas and muscle, is linked to cardio-metabolic complications commonly experienced in type 2 diabetes. A systematic review and meta-analysis was performed to determine the effect of exercise on ectopic fat in adults with type 2 diabetes. Relevant databases were searched to February 2016. Included were randomised controlled studies, which implemented≥4 weeks of aerobic and/or resistance exercise and quantified ectopic fat via magnetic resonance imaging, computed tomography, proton magnetic resonance spectroscopy or muscle biopsy before and after intervention...
February 2, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161372/successful-endoscopic-ultrasound-guided-ethanol-ablation-of-a-symptomatic-sporadic-insulinoma-in-a-patient-with-severe-comorbidities-not-suitable-for-pancreatic-surgery
#5
LETTER
K Burghardt, D Kaemmerer, A Michael, R Aschenbach, U A Müller, C Kloos, G Wolf
No abstract text is available yet for this article.
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161371/increased-odds-of-metabolic-syndrome-with-consumption-of-high-dietary-advanced-glycation-end-products-in-adolescents
#6
LETTER
A Saha, P Poojary, L Chan, K Chauhan, G Nadkarni, S Coca, J Uribarri
No abstract text is available yet for this article.
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161370/increased-fibrosis-and-angiogenesis-in-subcutaneous-gluteal-adipose-tissue-in-nascent-metabolic-syndrome
#7
I Jialal, B Adams-Huet, A Major, S Devaraj
AIMS: Metabolic syndrome (MetS) is globally a common disorder that predisposes to both diabetes and cardiovascular disease (CVD). There is a paucity of data on fibrosis and angiogenesis in adipose tissue (AT) in patients with nascent MetS uncomplicated by diabetes or CVD. Hence, we assayed various indices of fibrosis and angiogenesis in subcutaneous AT (SAT). METHODS: In both patients with MetS and matched controls, we determined fibrosis and the densities of CD31, VEGF and Angiopoietin (Angio) 2 and 1 by immunohistochemistry in gluteal SAT...
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161369/early-age-at-menarche-and-gestational-diabetes-mellitus-risk-results-from-the-healthy-baby-cohort-study
#8
H Li, L Shen, L Song, B Liu, X Zheng, S Xu, Y Wang
AIM: Early age at menarche has been reported to increase type 2 diabetes risk, but little is known of its impact on gestational diabetes mellitus (GDM) risk. The aim of this study was to examine the association between age at menarche and plasma glucose levels as well as GDM risk. METHODS: A total of 6900 pregnant women from the Healthy Baby Cohort Study were included in our analysis. Age at menarche was self-reported and categorized into five groups (9-11, 12, 13, 14 and 15-18 years of age)...
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161368/predicting-severe-hypoglycaemia-with-self-monitoring-of-blood-glucose-in-type-1-diabetes
#9
LETTER
A Moutairou, R Roussel, B Charbonnel, A Leye, B Detournay, K Mohammedi, L Potier
No abstract text is available yet for this article.
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28153377/effects-of-reducing-blood-pressure-on-renal-outcomes-in-patients-with-type-2-diabetes-focus-on-sglt2-inhibitors-and-empa-reg-outcome
#10
REVIEW
A J Scheen, P Delanaye
Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has enabled remarkable reductions in cardiovascular and all-cause mortality as well as in renal outcomes in patients with type 2 diabetes (T2D) and a history of cardiovascular disease in the EMPA-REG OUTCOME. These results have been attributed to haemodynamic rather than metabolic effects, in part due to the osmotic/diuretic action of empagliflozin and the reduction in arterial blood pressure (BP). The present narrative review includes the results of meta-analyses of trials evaluating the effects on renal outcomes of lowering BP in patients with T2D, with a special focus on the influence of baseline and achieved systolic BP, and compares the renal outcome results of the EMPA-REG OUTCOME with those of other major trials with inhibitors of the renin-angiotensin system in patients with T2D and the preliminary findings with other SGLT2 inhibitors, and also evaluates post hoc analyses from the EMPA-REG OUTCOME of special interest as regards the BP-lowering hypothesis and renal function...
January 30, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28139438/fgf21-deficiency-is-associated-with-childhood-obesity-insulin-resistance-and-hypoadiponectinaemia-the-bcams-study
#11
G Li, J Yin, J Fu, L Li, S F A Grant, C Li, M Li, J Mi, M Li, S Gao
OBJECTIVE: Fibroblast growth factor 21 (FGF21) exerts beneficial effects on metabolic homoeostasis and has been reported to be regulated by adiponectin, leptin and resistin. However, while an association between increased circulating FGF21 and metabolic disorders has been reported in adults, paediatric-specific data are lacking. DESIGN AND METHODS: This study investigated the relationship between FGF21 levels and obesity, insulin resistance (IR), the metabolic syndrome (MetS) and adipokines (adiponectin, leptin and resistin) in a cohort of 3231 Chinese youngsters aged 6-18...
January 27, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28139437/septic-ketoacidosis-evidence-from-patient-autopsies
#12
LETTER
C Palmiere, M P Scarpelli
No abstract text is available yet for this article.
January 27, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28139436/predictors-of-cardiovascular-risk-among-patients-with-type-1-diabetes-a-critical-analysis-of-the-metabolic-syndrome-and-its-components
#13
V Gingras, C Leroux, A Fortin, L Legault, R Rabasa-Lhoret
Patients with type 1 diabetes (T1D) are at increased risk for cardiovascular diseases. The metabolic syndrome (MetS), a complex disorder defined by a cluster of interconnected factors including abdominal obesity, hypertension, dyslipidaemia and insulin resistance, has been proposed to identify patients with T1D at high cardiovascular risk. The MetS has been identified in 8-45% of patients with T1D, depending on the definition and cohort studied. However, clinicians and researchers face several issues with the criteria for MetS in patients with T1D, therefore questioning its value in routine care...
January 27, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28139435/brain-derived-neurotrophic-factor-and-insulin-resistance-during-hyperinsulinaemic-euglycaemic-clamp-in-type-1-diabetes-patients-in-the-poprostu
#14
LETTER
A Uruska, P Niedzwiecki, A Araszkiewicz, D Zozulinska-Ziolkiewicz
No abstract text is available yet for this article.
January 27, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28131740/adipose-tissue-is-influenced-by-hypoxia-of-obstructive-sleep-apnea-syndrome-independent-of-obesity
#15
C E Thorn, B Knight, E Pastel, L J McCulloch, B Patel, A C Shore, K Kos
AIMS: Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular risk and diabetes independent of obesity. We investigated whether adipose tissue dysfunction is exacerbated due to increased tissue hypoxia. METHODS: Adipose tissue (AT) oxygenation was measured with a Clarke-type electrode (pATO2) in 16 men with OSAS before and after 4 months of continuous positive airway pressure therapy (CPAP) and in BMI-matched controls. Oxygenation was simultaneously monitored in arterial blood by pulse oximetry (SaO2); mixed blood in AT microcirculation by reflectance spectroscopy (SATO2) along with blood flow...
January 25, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28129999/long-term-risk-of-stroke-in-type-2-diabetes-patients-with-diabetic-ketoacidosis-a-population-based-propensity-score-matched-longitudinal-follow-up-study
#16
Y-L Chen, S-F Weng, C-Y Yang, J-J Wang, K-J Tien
AIM: To investigate the long-term risk of stroke in type 2 diabetes (T2D) patients with previous episodes of diabetic ketoacidosis (DKA). METHODS: This retrospective nationwide population-based cohort study was conducted using Taiwan's National Health Insurance database. Claims data from 2000 to 2002 were extracted for 3572 T2D patients with DKA and 7144 controls matched for age, gender, diabetes complications severity index, frequency of clinical visits and baseline comorbidities...
January 24, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28129998/association-between-earlier-age-at-natural-menopause-and-risk-of-diabetes-in-middle-aged-and-older-chinese-women-the-dongfeng-tongji-cohort-study
#17
L Shen, L Song, H Li, B Liu, X Zheng, L Zhang, J Yuan, Y Liang, Y Wang
AIM: Age at menopause is associated with cardiovascular disease, but little is known of its relationship with diabetes, and previous findings are controversial. The objective of this study was to evaluate the association between earlier menopause (at age ≤45 years) and the prevalence of diabetes in the Chinese population. METHODS: A total of 16,299 postmenopausal women, aged 42.0-94.3 years, who completed the study questionnaires, underwent medical examinations and provided blood samples, were included in our analysis...
January 24, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28129997/effect-of-weightun-heme-oxygenase-1-tissue-expression
#18
LETTER
C Ress, A R Moschen, V Thoeni, C F Ebenbichler, H Weiss, C Molnar, G Weiss, H Tilg, S Kaser
No abstract text is available yet for this article.
January 24, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28108087/reproducibility-and-least-significant-differences-of-oral-glucose-tolerance-test-derived-parameters-in-a-postmenopausal-population-without-diabetes
#19
LETTER
F P Van de Velde, A Dierickx, H Depypere, J R Delanghe, J-M Kaufman, B Lapauw
No abstract text is available yet for this article.
January 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28089503/comparison-of-two-techniques-of-adiponectin-assay-elisa-and-immunoturbidimetry-should-we-move-towards-standardization
#20
LETTER
S Fellahi, L Béraud, G Marlin, C Vigouroux, J Warszawski, J Capeau, J-P Bastard
No abstract text is available yet for this article.
January 12, 2017: Diabetes & Metabolism
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