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Diabetes & Metabolism

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https://www.readbyqxmd.com/read/28778564/comparison-of-hepatocellular-carcinoma-risk-between-patients-treated-with-glimepiride-and-gliclazide
#1
LETTER
J-Y Lee, G Kim, Y-H Lee, B-W Lee, B-S Cha, C M Nam, E S Kang
No abstract text is available yet for this article.
August 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28778563/dipeptidyl-peptidase-4-inhibitors-and-risk-of-arthralgia-a-systematic-review-and-meta-analysis
#2
REVIEW
P Men, N He, C Song, S Zhai
BACKGROUND: The US Food and Drug Administration has warned that treatment with dipeptidyl peptidase (DPP)-4 inhibitors may promote serious arthralgia. However, the clinical evidence for this is relatively lacking. OBJECTIVE: For this reason, a systematic review and meta-analysis of randomized controlled trials (RCTs) were carried out to determine the relationship between DPP-4 inhibitors and risk of arthralgia, and also to investigate any potential risk factors...
August 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28774785/heart-rate-variability-in-fetuses-of-type-1-diabetes-pregnancies
#3
LETTER
Y Hamoud, J de Jonckheere, A Vambergue, V Houfflin-Debarge, L Storme, M Flocteil, P Deruelle, C Garabedian
No abstract text is available yet for this article.
July 31, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28774784/serum-soluble-trem2-is-a-potential-novel-biomarker-of-cognitive-impairment-in-japanese-non-obese-patients-with-diabetes
#4
LETTER
M Tanaka, H Yamakage, S Masuda, T Inoue, R Ohue-Kitano, R Araki, Y Matoba, M Saito, T Nagaoka, K Yonezawa, T Tanaka, M Suzuki, M Sawamura, M Nishimura, S Odori, H Wada, K Kotani, T Kusakabe, A Shimatsu, K Hasegawa, N Satoh-Asahara
No abstract text is available yet for this article.
July 31, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28754263/clinical-inertia-and-its-impact-on-treatment-intensification-in-people-with-type-2-diabetes-mellitus
#5
REVIEW
G Reach, V Pechtner, R Gentilella, A Corcos, A Ceriello
Many people with type 2 diabetes mellitus (T2DM) fail to achieve glycaemic control promptly after diagnosis and do not receive timely treatment intensification. This may be in part due to 'clinical inertia', defined as the failure of healthcare providers to initiate or intensify therapy when indicated. Physician-, patient- and healthcare-system-related factors all contribute to clinical inertia. However, decisions that appear to be clinical inertia may, in fact, be only 'apparent' clinical inertia and may reflect good clinical practice on behalf of the physician for a specific patient...
July 25, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28751101/association-of-handgrip-strength-with-b-type-natriuretic-peptide-levels-and-cardiovascular-events-in-patients-with-type-2-diabetes
#6
LETTER
H Hamasaki
No abstract text is available yet for this article.
July 24, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28735930/brain-atrophy-in-ageing-estimating-effects-of-blood-glucose-levels-vs-other-type-2-diabetes-effects
#7
LETTER
E I Walsh, M Shaw, P Sachdev, K J Anstey, N Cherbuin
No abstract text is available yet for this article.
July 20, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#8
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28720342/severe-hypoglycaemia-is-a-major-predictor-of-incident-diabetic-retinopathy-in-japanese-patients-with-type-2-diabetes
#9
S Tanaka, R Kawasaki, S Tanaka-Mizuno, S Iimuro, S Matsunaga, T Moriya, S Ishibashi, S Katayama, Y Ohashi, Y Akanuma, H Sone, H Yamashita
AIM: Hypoglycaemia is a common complication in diabetes patients. However, its relationship with retinopathy has not been well documented in patients with type 2 diabetes (T2D). This study aimed to investigate the associations between hypoglycaemia and the incidence and progression of diabetic retinopathy (DR). METHODS: In this longitudinal cohort study, which was part of the Japan Diabetes Complications Study (JDCS), adult patients with T2D were recruited at 59 diabetes clinics across Japan...
July 15, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28709749/the-brown-fat-secreted-adipokine-neuregulin-4-is-decreased-in-gestational-diabetes-mellitus
#10
S Kralisch, A Hoffmann, J Kratzsch, M Blüher, M Stumvoll, M Fasshauer, T Ebert
AIMS: Neuregulin 4 has recently been recognized as a novel adipokine secreted by brown adipose tissue (BAT), with beneficial effects on murine insulin resistance and hepatic steatosis. Yet, thus far, neither regulation of neuregulin 4 in gestational diabetes mellitus (GDM) nor its longitudinal changes in the peripartum period have been elucidated. METHODS: Circulating neuregulin 4 levels were measured by ELISA in 74 women with GDM and 74 healthy, gestational-age-matched controls...
July 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28693962/the-impact-of-triglycerides-on-glucose-tolerance-lipotoxicity-revisited
#11
REVIEW
M Seghieri, D Tricò, A Natali
Elevated plasma triglycerides (TGs) are early key features of conditions associated with a dysregulation in glucose metabolism and may predict the development of type 2 diabetes (T2D) over time. Although the acute ingestion of lipid, either mixed with or shortly before the meal, is neutral or slightly beneficial on glucose tolerance, a short-term increase in plasma TGs induced by either an i.v. lipid infusion or a high-fat diet produces a deterioration of glucose control. Accordingly, chronic lowering of plasma TGs by fibrates improves glucose homeostasis and may also prevent T2D...
July 7, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28690125/carbamylation-is-a-competitor-of-glycation-for-protein-modification-in-vivo
#12
C Nicolas, S Jaisson, L Gorisse, F J Tessier, C Niquet-Léridon, P Jacolot, C Pietrement, P Gillery
AIM: Chronic kidney disease (CKD) and diabetes mellitus are two diseases that accelerate protein molecular ageing through carbamylation and glycation reactions, characterized by the binding of urea-derived isocyanic acid and of sugars on proteins, respectively. These two reactions target the same protein amino groups and, thus, compete with each other. Such competition may arise especially in diabetic patients with nephropathy. This study aimed to evaluate their potential competitive effects in vitro and under conditions reproducing CKD and/or diabetes in vivo...
July 6, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28687221/low-serum-c-reactive-protein-levels-predict-90-day-mortality-in-hypoglycaemic-patients
#13
LETTER
A Bonaventura, F Gallo, F Carbone, G Sacchi, L Liberale, F Dallegri, D Maggi, F Montecucco, R Cordera
No abstract text is available yet for this article.
July 4, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28684163/pioglitazone-and-lung-cancer-risk-in-taiwanese-patients-with-type-2-diabetes
#14
LETTER
C-H Tseng
No abstract text is available yet for this article.
July 3, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28669514/identification-of-urine-metabolites-associated-with-5-year-changes-in-biomarkers-of-glucose-homoeostasis
#15
N Friedrich, T Skaaby, M Pietzner, K Budde, B H Thuesen, M Nauck, A Linneberg
AIM: Metabolomics provides information on pathogenetic mechanisms and targets for interventions, and may improve risk stratification. During the last decade, metabolomics studies were used to gain deeper insight into the pathogenesis of diabetes mellitus. However, longitudinal metabolomics studies of possible subclinical states of disturbed glucose metabolism are limited. Therefore, the aim of this study was to analyze the associations between baseline urinary metabolites and 5-year changes in continuous markers of glucose homoeostasis, including fasting glucose, HbA1c and homoeostasis model assessment of insulin resistance (HOMA-IR) index values...
June 29, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28669513/high-efficacy-of-screening-for-diabetes-and-prediabetes-in-cardiac-rehabilitation-after-an-acute-coronary-syndrome-acs-the-rehabdiab-study
#16
LETTER
B Vergès, B Patois-Vergès, K Goueslard, J Cottenet, A Nguyen, S Tatulashvili, M-C Blonde, C Quantin
No abstract text is available yet for this article.
June 29, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28669512/family-history-of-type-1-and-type-2-diabetes-and-risk-of-latent-autoimmune-diabetes-in-adults-lada
#17
R Hjort, L Alfredsson, T Andersson, P-O Carlsson, V Grill, L Groop, M Martinell, B Rasouli, P Storm, T Tuomi, S Carlsson
BACKGROUND: A family history of diabetes (FHD) is a strong predictor of diabetes risk, yet has rarely been investigated in latent autoimmune diabetes in adults (LADA). This study therefore investigated the risk of LADA and type 2 diabetes (T2D) in relation to FHD, taking into account the type of diabetes in relatives. METHODS: Data from a population-based study were used, including incident cases of LADA [glutamic acid decarboxylase antibody (GADA)-positive, n=378] and T2D (GADA-negative, n=1199), and their matched controls (n=1484)...
June 29, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28648835/effect-of-glp-1-receptor-agonist-on-gastrointestinal-tract-motility-and-residue-rates-as-evaluated-by-capsule-endoscopy
#18
Y Nakatani, M Maeda, M Matsumura, R Shimizu, N Banba, Y Aso, T Yasu, H Harasawa
AIM: This study evaluated the effects of a glucagon-like peptide-1 receptor agonist on gastrointestinal (GI) tract motility and residue rates by examining GI transit time and lumen using capsule endoscopy. MATERIAL AND METHODS: GI motility and lumen were assessed by capsule endoscopy before and after liraglutide administration in 14 patients with type 2 diabetes mellitus (T2DM). RESULTS: Gastric transit time in the group with diabetic neuropathy (DN) was 1:12:36±1:04:30h before liraglutide administration and 0:48:40±0:32:52h after administration (nonsignificant difference, P=0...
June 22, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28648834/combination-avelumab-and-utomilumab-immunotherapy-can-induce-diabetic-ketoacidosis
#19
LETTER
P W Atkins, D M Thompson
No abstract text is available yet for this article.
June 22, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28622950/glycaemic-control-and-hypoglycaemia-with-insulin-glargine-300u-ml-versus-insulin-glargine-100u-ml-in-insulin-na%C3%A3-ve-people-with-type-2%C3%A2-diabetes-12-month-results-from-the-edition-3-trial
#20
G B Bolli, M C Riddle, R M Bergenstal, M Wardecki, H Goyeau, P D Home
AIM: To explore if efficacy and safety findings for insulin glargine 300U/mL (Gla-300) versus insulin glargine 100U/mL (Gla-100), observed over 6 months in insulin-naïve people with type 2 diabetes, are maintained after 12 months. METHODS: EDITION 3 was a phase 3a, randomized, multicentre, open-label, parallel-group, treat-to-target study of once-daily Gla-300 versus Gla-100 (target fasting self-monitored plasma glucose, 4.4-5.6mmol/L [80-100mg/dL]). Participants completing the initial 6-month treatment phase continued their previously allocated basal insulin...
June 13, 2017: Diabetes & Metabolism
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