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Diabetes & Metabolism

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https://www.readbyqxmd.com/read/28325589/all-cause-mortality-in-patients-with-diabetes-under-glucagon-like-peptide-1-agonists-a-population-based-open-cohort-study
#1
K A Toulis, W Hanif, P Saravanan, B H Willis, T Marshall, B Kumarendran, K Gokhale, S Ghosh, K K Cheng, P Narendran, G N Thomas, K Nirantharakumar
AIM: The glucagon-like peptide-1 receptor agonist (GLP1a) liraglutide has been described to benefit patients with type 2 diabetes mellitus (T2DM) at high cardiovascular risk. However, there are still uncertainties relating to these cardiovascular benefits: whether they also apply to an unselected diabetic population that includes low-risk patients, represent a class-effect, and could be observed in a real-world setting. METHODS: We conducted a population-based, retrospective open cohort study using data derived from The Health Improvement Network database between Jan 2008 to Sept 2015...
March 18, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28318913/characteristics-and-predictors-of-obstructive-sleep-apnoea-in-patients-with-type-2-diabetes
#2
LETTER
M José M C Souza, A Kelley L Medeiros, M M B Carvalho, C A Medeiros, T C Lustosa, T Leiane Guerra de Couto, R R M Silva, M A B B Correia, R A P Oliveira, M V F P Silva, I V Secundo, R P Pedrosa
No abstract text is available yet for this article.
March 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28318912/less-liver-fibrosis-in-metabolically-healthy-compared-with-metabolically-unhealthy-obese-patients-with-non-alcoholic-fatty-liver-disease
#3
Y Gutiérrez-Grobe, E Juárez-Hernández, B A Sánchez-Jiménez, M H Uribe-Ramos, M H Ramos-Ostos, M Uribe, N C Chávez-Tapia
AIM: This cross-sectional study evaluated liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), and compared the characteristics of metabolically healthy obese (MHO) with metabolically unhealthy obese (MUHO) patients. METHODS: The study was nested within a randomized clinical trial (RCT) and included obese patients with NAFLD, as determined by liver ultrasonography. Fibrosis was assessed by transient elastography, and AST-to-platelet ratio index (APRI) and NAFLD score...
March 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28314670/diabetes-remission-after-bariatric-surgery-in-obese-patients-with-haemochromatosis
#4
LETTER
F Phan, C Vatier, C Vauloup-Soupault, C Poitou, J-L Bouillot, J-M Oppert, J Aron-Wisnewsky
No abstract text is available yet for this article.
March 14, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28283288/increase-in-cortisol-acth-ratio-after-chronic-treatment-with-liraglutide-in-patients-with-type-2-diabetes
#5
LETTER
S Kamei, H Kaneto, A Tanabe, T Kinoshita, A Obata, T Kimura, H Hirukawa, F Tatsumi, M Shimoda, K Kohara, Takatoshi Anno, S Nakanishi, T Mune, K Kaku
No abstract text is available yet for this article.
March 7, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28279650/hyperglycaemia-within-the-first-month-after-allogeneic-haematopoietic-stem-cell-transplantation-is-an-independent-risk-factor-for-overall-survival-in-patients-with-acute-myeloid-leukaemia
#6
LETTER
F Aberer, S Kremser, J K Mader, W Zinke-Cerwenka, H Greinix, N J Tripolt, T R Pieber, A Zebisch, H Sill, A Oulhaj, H Sourij, A Wölfler
No abstract text is available yet for this article.
March 6, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28259539/oxidative-and-energetic-stresses-mediate-beta-cell-dysfunction-induced-by-pgc-1%C3%AE
#7
A Besseiche, J-P Riveline, L Delavallée, F Foufelle, J-F Gautier, B Blondeau
AIM: Alteration of functional beta-cell mass in adults can be programmed by adverse events during fetal life. Previously, it was demonstrated that high glucocorticoid (GC) levels during fetal life participate in this programming by inhibition of beta-cell development. More specifically, GC levels stimulate expression of peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α), a transcriptional co-regulator of the GC receptor (GR), which per se impairs beta-cell mass and function when overexpressed...
March 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28259538/association-between-diabetes-and-changes-in-hearing-a-cross-sectional-study
#8
LETTER
S Lebech Cichosz, O Hejlesen
No abstract text is available yet for this article.
March 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28238600/moderate-intensity-sports-and-exercise-is-associated-with-glycaemic-control-in-women-with-gestational-diabetes
#9
S F Ehrlich, M M Hedderson, S D Brown, B Sternfeld, L Chasan-Taber, J Feng, J Adams, J Ching, Y Crites, C P Quesenberry, A Ferrara
AIM: To assess the association of regular, unsupervised sports and exercise during pregnancy, by intensity level, with glycaemic control in women with gestational diabetes (GDM). METHODS: Prospective cohort study of 971 women who, shortly after being diagnosed with GDM, completed a Pregnancy Physical Activity Questionnaire assessing moderate and vigorous intensity sports and exercise in the past 3 months. Self-monitored capillary glucose values were obtained for the 6-week period following the questionnaire, with optimal glycaemic control defined≥80% values meeting the targets<5...
February 23, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28236571/multicentre-randomized-controlled-trial-with-sensor-augmented-pump-vs-multiple-daily-injections-in-hospitalized-patients-with-type-2-diabetes-in-china-time-to-reach-target-glucose
#10
W Gu, Y Liu, Y Chen, W Deng, X Ran, L Chen, D Zhu, J Yang, J Shin, S W Lee, T L Cordero, Y Mu
AIM: Sensor-augmented pump (SAP) technology, which combines continuous subcutaneous insulin infusion (CSII) and real-time continuous glucose monitoring (RT-CGM), has been available for several years in China. In this study, the time required to reach predefined glycaemic targets with SAP vs multiple daily injection (MDI) therapy was compared in hospitalized patients with type 2 diabetes mellitus (T2DM). METHODS: Adults (aged 18-65 years) with T2DM treated with insulin and admitted to hospital for glucose management were randomized to either SAP (Medtronic MiniMed™ Paradigm™ 722 system) or MDI with blinded CGM (Medtronic MiniMed CGMS System Gold™) for a 2-week period...
February 21, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28214129/the-novel-adipokine-hepatokine-fetuin-b-in-severe-human-and-murine-diabetic-kidney-disease
#11
LETTER
S Kralisch, A Hoffmann, N Klöting, A Bachmann, J Kratzsch, M Blüher, M-Z Zhang, R C Harris, M Stumvoll, M Fasshauer, T Ebert
No abstract text is available yet for this article.
February 14, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28190592/maternal-and-paternal-family-history-of-diabetes-in-second-degree-relatives-and-metabolic-outcomes-at-age-5-6-years-the-abcd-study
#12
A J J M Oostvogels, C P Landstra, L Britsemmer, R Lodewijkx, K Stronks, T J Roseboom, T G M Vrijkotte
AIM: To investigate whether children with a family history of diabetes (FHD) in second-degree relatives (grandparents, aunts/uncles) are at increased risk of developing obesity and diabetes, and whether the risk differs between maternal or paternal transmission. METHODS: In the multiethnic population-based cohort Amsterdam-Born Children and Their Development (ABCD) Study, body mass index (BMI), waist-to-height ratio (WHR), fat percentage (fat%), fasting glucose and C-peptide in 5- or 6-year-old children with no second-degree FHD (n=2226) were compared with children with maternal-only (n=353), paternal-only (n=281) or both maternal and paternal (n=164) second-degree FHD...
February 10, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28169086/basal-insulin-treatment-intensification-in-patients-with-type-2-diabetes-mellitus-a-comprehensive-systematic-review-of-current-options
#13
REVIEW
D Raccah
AIM: As type 2 diabetes mellitus progresses, most patients require treatment with basal insulin in combination with another agent to achieve recommended glycaemic targets. The purpose of this systematic review was to examine the evidence supporting the use of the available add-on treatments [rapid-acting insulin (RAI), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), dipeptidyl peptidase (DPP)-4 inhibitors and sodium-glucose cotransporter-2 (SGLT-2) inhibitors] to basal insulin...
February 3, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28162956/exercise-and-ectopic-fat-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#14
REVIEW
A Sabag, K L Way, S E Keating, R N Sultana, H T O'Connor, M K Baker, V H Chuter, J George, N A Johnson
Ectopic adipose tissue surrounding the intra-abdominal organs (visceral fat) and located in the liver, heart, pancreas and muscle, is linked to cardio-metabolic complications commonly experienced in type 2 diabetes. A systematic review and meta-analysis was performed to determine the effect of exercise on ectopic fat in adults with type 2 diabetes. Relevant databases were searched to February 2016. Included were randomised controlled studies, which implemented≥4 weeks of aerobic and/or resistance exercise and quantified ectopic fat via magnetic resonance imaging, computed tomography, proton magnetic resonance spectroscopy or muscle biopsy before and after intervention...
February 2, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161372/successful-endoscopic-ultrasound-guided-ethanol-ablation-of-a-symptomatic-sporadic-insulinoma-in-a-patient-with-severe-comorbidities-not-suitable-for-pancreatic-surgery
#15
LETTER
K Burghardt, D Kaemmerer, A Michael, R Aschenbach, U A Müller, C Kloos, G Wolf
No abstract text is available yet for this article.
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161371/increased-odds-of-metabolic-syndrome-with-consumption-of-high-dietary-advanced-glycation-end-products-in-adolescents
#16
LETTER
A Saha, P Poojary, L Chan, K Chauhan, G Nadkarni, S Coca, J Uribarri
No abstract text is available yet for this article.
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161370/increased-fibrosis-and-angiogenesis-in-subcutaneous-gluteal-adipose-tissue-in-nascent-metabolic-syndrome
#17
I Jialal, B Adams-Huet, A Major, S Devaraj
AIMS: Metabolic syndrome (MetS) is globally a common disorder that predisposes to both diabetes and cardiovascular disease (CVD). There is a paucity of data on fibrosis and angiogenesis in adipose tissue (AT) in patients with nascent MetS uncomplicated by diabetes or CVD. Hence, we assayed various indices of fibrosis and angiogenesis in subcutaneous AT (SAT). METHODS: In both patients with MetS and matched controls, we determined fibrosis and the densities of CD31, VEGF and Angiopoietin (Angio) 2 and 1 by immunohistochemistry in gluteal SAT...
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161369/early-age-at-menarche-and-gestational-diabetes-mellitus-risk-results-from-the-healthy-baby-cohort-study
#18
H Li, L Shen, L Song, B Liu, X Zheng, S Xu, Y Wang
AIM: Early age at menarche has been reported to increase type 2 diabetes risk, but little is known of its impact on gestational diabetes mellitus (GDM) risk. The aim of this study was to examine the association between age at menarche and plasma glucose levels as well as GDM risk. METHODS: A total of 6900 pregnant women from the Healthy Baby Cohort Study were included in our analysis. Age at menarche was self-reported and categorized into five groups (9-11, 12, 13, 14 and 15-18 years of age)...
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28161368/predicting-severe-hypoglycaemia-with-self-monitoring-of-blood-glucose-in-type-1-diabetes
#19
LETTER
A Moutairou, R Roussel, B Charbonnel, A Leye, B Detournay, K Mohammedi, L Potier
No abstract text is available yet for this article.
February 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28153377/effects-of-reducing-blood-pressure-on-renal-outcomes-in-patients-with-type-2-diabetes-focus-on-sglt2-inhibitors-and-empa-reg-outcome
#20
REVIEW
A J Scheen, P Delanaye
Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has enabled remarkable reductions in cardiovascular and all-cause mortality as well as in renal outcomes in patients with type 2 diabetes (T2D) and a history of cardiovascular disease in the EMPA-REG OUTCOME. These results have been attributed to haemodynamic rather than metabolic effects, in part due to the osmotic/diuretic action of empagliflozin and the reduction in arterial blood pressure (BP). The present narrative review includes the results of meta-analyses of trials evaluating the effects on renal outcomes of lowering BP in patients with T2D, with a special focus on the influence of baseline and achieved systolic BP, and compares the renal outcome results of the EMPA-REG OUTCOME with those of other major trials with inhibitors of the renin-angiotensin system in patients with T2D and the preliminary findings with other SGLT2 inhibitors, and also evaluates post hoc analyses from the EMPA-REG OUTCOME of special interest as regards the BP-lowering hypothesis and renal function...
January 30, 2017: Diabetes & Metabolism
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