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Diabetes & Metabolism

A Nitta, S Imai, S Kajiyama, T Miyawaki, S Matsumoto, N Ozasa, S Kajiyama, Y Hashimoto, M Tanaka, M Fukui
AIMS: Our aim was to evaluate the acute effect of eating sweet snacks at different times of day on glycaemic parameters in young women without diabetes. METHODS: In this randomized controlled three-treatment crossover study, 17 women [(means ± SD) age: 21.2 ± 0.8 years, BMI: 20.7 ± 2.5 kg/m2, HbA1c : 36 ± 2 mmol/mol (5.1 ± 0.2%)] wore flash (continuous) glucose monitoring systems for 7 days. Each participant consumed identical test meals on days 4, 5 and 6, but consumed sweet snacks (baked cake: 498 kcal; 53...
November 1, 2018: Diabetes & Metabolism
J-F Yale, V R Aroda, B Charbonnel, A J Sinclair, C Trescoli, A Cahn, G Bigot, A Merino-Trigo, C Brulle-Wohlhueter, G B Bolli, R Ritzel
AIM: Older people with type 2 diabetes (T2DM) are at an increased risk of hypoglycaemia and its consequences. However, efficacy and safety data for basal insulin therapy are limited in these individuals. This patient-level meta-analysis assessed the treatment effects of insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100) in people with T2DM ≥ 65 years old. METHODS: Data were pooled for patients randomised to receive Gla-300 or Gla-100 in the Phase 3a, treat-to-target EDITION 1, 2 and 3 trials...
October 23, 2018: Diabetes & Metabolism
A Mantovani, E Sani, A Fassio, A Colecchia, O Viapiana, D Gatti, L Idolazzi, M Rossini, G Salvagno, G Lippi, G Zoppini, C D Byrne, E Bonora, Giovanni Targher
AIM: Information is lacking on the association between non-alcoholic fatty liver disease (NAFLD) and bone mineral density (BMD) or circulating bone turnover biomarkers in post-menopausal women with type 2 diabetes (T2DM). METHODS: We recruited 77 white post-menopausal women with T2DM, who consecutively attended our diabetes outpatient service during a 3-month period. Ultrasonography and transient elastography (Fibroscan® ) were used for diagnosing and staging NAFLD...
October 10, 2018: Diabetes & Metabolism
M Kwapich, D Lacroix, S Espiard, S Ninni, F Brigadeau, C Kouakam, P Degroote, J M Laurent, V Tiffreau, A Jannin, L Humbert, A Ben Hamou, C Tard, R Ben Yaou, N Lamblin, D Klug, P Richard, C Vigouroux, G Bonne, M C Vantyghem
AIMS: Mutations of the LMNA gene encoding lamin A/C induce heterogeneous phenotypes ranging from cardiopathies and myopathies to lipodystrophies. The aim of this study was to compare cardiometabolic complications in patients with heterozygous LMNA mutations at the 482nd codon, the 'hotspot' for partial lipodystrophy, with carriers of other, non-R482 LMNA mutations. METHODS AND RESULTS: This study included 29 patients with R482 LMNA mutations, 29 carriers of non-R482 LMNA mutation and 19 control subjects...
October 1, 2018: Diabetes & Metabolism
F Carbone, G Adami, L Liberale, A Bonaventura, M Bertolotto, G Andraghetti, N Scopinaro, G B Camerini, F S Papadia, R Cordera, F Dallegri, F Montecucco
AIM: Bariatric surgery has been shown to effectively improve glycaemic control in morbidly obese subjects. However, the molecular bases of this association are still elusive and may act independently of weight loss. Here, our retrospective study has investigated the inflammatory molecule osteopontin (OPN) as a potential predictor of type 2 diabetes mellitus (T2DM) remission. METHODS: Baseline serum levels of OPN were analyzed in 41 T2DM patients who underwent bariatric surgery...
September 27, 2018: Diabetes & Metabolism
F Bonnet, A J Scheen
Chronic low-grade inflammation is a recognized key feature associated with type 2 diabetes mellitus (T2DM) and its complications. In prospective randomized trials, sodium-glucose cotransporter type 2 (SGLT2) inhibitors have demonstrated benefits related to several cardiovascular and renal risk factors, including HbA1c , blood pressure, body weight, renal hyperfiltration, and improvement of cardiorenal outcomes. SGLT2 inhibitors may improve adipose tissue function and induce decreases in serum leptin, TNF-α and IL-6 while increasing adiponectin...
September 26, 2018: Diabetes & Metabolism
A Feldman, S K Eder, T K Felder, B Paulweber, S Zandanell, L Stechemesser, M Schranz, G Strebinger, U Huber-Schönauer, D Niederseer, W Patsch, D Weghuber, J Tevini, C Datz, E Aigner
INTRODUCTION: As a small proportion of obese individuals do not develop metabolic complications and non-alcoholic fatty liver disease (NAFLD), this study aimed to provide a comprehensive clinical, metabolic and genetic description of obese subjects with healthy livers. METHODS: A total of 183 subjects were stratified, according to BMI, presence of metabolic syndrome, biochemical liver tests and hepatic steatosis on ultrasound, into: (i) lean controls (n = 69); (ii) obese healthy (n = 50); and (iii)obese NAFLD (n = 62) groups...
September 26, 2018: Diabetes & Metabolism
I Medina-Vera, M Sanchez-Tapia, L Noriega-López, O Granados-Portillo, M Guevara-Cruz, A Flores-López, A Avila-Nava, M L Fernández, A R Tovar, N Torres
AIM: To study the effects of a functional food-based dietary intervention on faecal microbiota and biochemical parameters in patients with type 2 diabetes (T2D). MATERIALS AND METHODS: This placebo-controlled, randomized, double-blind study included 81 patients with T2D divided into two 3-month treatment groups: one following a reduced-energy diet with a dietary portfolio (DP) comprising high-fibre, polyphenol-rich and vegetable-protein functional foods; the other taking a placebo (P)...
September 25, 2018: Diabetes & Metabolism
B M Mishriky, D M Cummings, J R Powell, K A Sewell, R J Tanenberg
AIMS: Our aim was to compare once-weekly semaglutide to incretin-based therapies - defined as either dipeptidyl peptidase-4 inhibitors (DPP-4i) or other glucagon-like peptide-1 receptor agonist (GLP-1RA) - in patients with type 2 diabetes. METHODS: We searched for randomized trials comparing once-weekly semaglutide to other incretin-based therapies in patients with type 2 diabetes. We pooled trials that compared semaglutide to other GLP-1RA together, and those comparing semaglutide to DPP-4i together...
September 20, 2018: Diabetes & Metabolism
Z-J Sun, X-Q Li, D-Y Chang, S-X Wang, G Liu, M Chen, M-H Zhao
AIMS: As the potential role of the complement system in diabetic nephropathy (DN) is increasingly reported, this study aimed to investigate C1q and C3c deposition as seen on renal histopathology, as well as its association with clinical and pathological parameters, in DN patients. METHODS: Renal biopsy specimens from 161 DN patients were investigated using direct immunofluorescence, light, and electron microscopy. For direct immunofluorescence, staining for C1q and C3c on fresh-frozen renal tissue was performed immediately after biopsy...
September 19, 2018: Diabetes & Metabolism
G Fagherazzi, P Ravaud
Digital medicine, digital research and artificial intelligence (AI) have the power to transform the field of diabetes with continuous and no-burden remote monitoring of patients' symptoms, physiological data, behaviours, and social and environmental contexts through the use of wearables, sensors and smartphone technologies. Moreover, data generated online and by digital technologies - which the authors suggest be grouped under the term 'digitosome' - constitute, through the quantity and variety of information they represent, a powerful potential for identifying new digital markers and patterns of risk that, ultimately, when combined with clinical data, can improve diabetes management and quality of life, and also prevent diabetes-related complications...
September 19, 2018: Diabetes & Metabolism
F Maillard, S Rousset, B Pereira, Y Boirie, M Duclos, N Boisseau
No abstract text is available yet for this article.
September 19, 2018: Diabetes & Metabolism
A Wojtusciszyn, J Branchereau, L Esposito, L Badet, F Buron, M Chetboun, L Kessler, E Morelon, T Berney, F Pattou, P-Y Benhamou, M-C Vantyghem
While either pancreas or pancreatic islet transplantation can restore endogenous insulin secretion in patients with diabetes, no beta-cell replacement strategies are recommended in the literature. For this reason, the aim of this national expert panel statement is to provide information on the different kinds of beta-cell replacement, their benefit-risk ratios and indications for each type of transplantation, according to type of diabetes, its control and association with end-stage renal disease. Allotransplantation requires immunosuppression, a risk that should be weighed against the risks of poor glycaemic control, diabetic lability and severe hypoglycaemia, especially in cases of unawareness...
September 14, 2018: Diabetes & Metabolism
A M Wägner, G Miranda-Calderín, M A Ugarte-Lopetegui, H Marrero-Santiago, L Suárez-Castellano, M J López-Madrazo, M P Alberiche-Ruano, N Abselam Ahmed, C Alemán, A Castellot-Martín, A Díez Del Pino, F J Nóvoa-Mogollón
AIMS: To assess the effect of the GLP-1 analogue liraglutide on measures of cardiac function and physical performance in patients with type 2 diabetes (T2D). METHODS: In this phase-IV randomized double-blind placebo-controlled parallel-group clinical trial at a tertiary hospital, T2D patients with HbA1c levels of 7-10% with oral agents and/or intermediate-/long-acting insulin were allocated (computer-generated randomization, ratio 1:1) to either liraglutide 1.8 mg/day or a placebo for 6 months...
September 14, 2018: Diabetes & Metabolism
Mayuko Harada, Kazuya Fujihara, Taeko Osawa, Masahiko Yamamoto, Masanori Kaneko, Masahiro Ishizawa, Yasuhiro Matsubayashi, Takaho Yamada, Nauta Yamanaka, Hiroyasu Seida, Satoru Kodama, Wataru Ogawa, Hirohito Sone
AIM: To examine the association between treatment-achieved HbA1c values and incidence of both coronary artery disease (CAD) and severe eye disease with different diabetes treatments. METHODS: Associations of treatment-achieved HbA1c were investigated in various treatment groups [diet only; insulin; sulphonylurea (SU) alone; SU with glinides; and antihyperglycaemic agents other than glinides, SU or insulin] taken from a nationwide claims database of 14,633 Japanese diabetes patients...
September 10, 2018: Diabetes & Metabolism
M Liu, S-W Liu, L-J Wang, Y-M Bai, X-Y Zeng, H-B Guo, Y-N Liu, Y-Y Jiang, W-L Dong, G-X He, M-G Zhou, S-C Yu
AIMS: The prevalence of diabetes in China is among the highest in the world. For this reason, findings from the 2016 Global Burden of Disease (GBD) study were used to calculate the burden of hyperglycaemia and diabetes in China. METHODS: Following the general analytical strategy used in GBD 2016, diabetes prevalence and mortality were analyzed by age and gender. Trends in disability-adjusted life years (DALYs) due to diabetes were assessed in 33 province-level administrative units from 1990 to 2016, and similar data were provided for chronic kidney disease (CKD) related to diabetes and, as an overall summarizing measure, for hyperglycaemia expressed as high fasting plasma glucose (HFPG)...
September 6, 2018: Diabetes & Metabolism
A Mantovani, R Rigolon, T Turino, I Pichiri, A Falceri, A Rossi, P L Temporelli, S Bonapace, G Lippi, G Zoppini, E Bonora, C D Byrne, G Targher
AIM: We aimed to assess the association between decreasing estimated glomerular filtration rate (eGFR) or abnormal albuminuria and the risk of certain cardiac conduction defects in patients with type 2 diabetes mellitus (T2DM). METHODS: We examined a hospital-based sample of 923 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014. Standard electrocardiograms (ECGs) were performed in all patients. eGFR was estimated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, whilst albuminuria was measured by an immuno-nephelometric method on morning spot urine samples...
September 5, 2018: Diabetes & Metabolism
A-L Borel, R Tamisier, P Böhme, P Priou, A Avignon, P-Y Benhamou, H Hanaire, J-L Pépin, L Kessler, P Valensi, P Darmon, F Gagnadoux
AIM: Because type 2 diabetes (T2D) is related to obesity, it is often associated with obstructive sleep apnoea syndrome (OSAS), although OSAS is also frequently diagnosed in patients with type 1 diabetes (T1D) and may promote gestational diabetes. Thus, this systematic review of the scientific evidence aimed to evaluate the epidemiological association between OSAS and all forms of diabetes, the current understanding of the pathophysiological mechanisms behind these associations, the expected benefits and limitations of OSAS treatment in patients with diabetes and, finally, to propose which patients require screening for OSAS...
September 3, 2018: Diabetes & Metabolism
F Liu, H Wang, W Feng, X Ye, X Sun, C Jiang, X Chu, P Zhang, C Jiang, Y Wang, D Zhu, Y Bi
AIM: Type 1 innate lymphoid cells (ILC1s) play a major role in regulating systemic inflammatory diseases. However, the relationship between ILC1s and type 2 diabetes (T2D) remains unclear. Thus, the present study investigated the relationship between ILC1s and glucose homoeostasis in humans. METHODS: A total of 37 newly diagnosed T2D patients and 32 subjects with normal glucose tolerance (NGT), matched for age and body mass index (BMI), were enrolled in the study...
September 3, 2018: Diabetes & Metabolism
P Prabu, S Rome, C Sathishkumar, C Gastebois, E Meugnier, V Mohan, M Balasubramanyam
AIMS: MicroRNAs (miRNAs) from extracellular vesicles (EVs) have been proposed as promising biomarkers for a number of diseases. In this study, their potential as urine-based biomarkers of diabetic nephropathy (DN) was assessed. METHODS: MiRNAs were profiled in urinary EVs from 160 fasting subjects with normal glucose tolerance (NGT) and in T2DM patients with either microalbumininuria (MIC) or macroalbuminuria (MAC). RESULTS: A total of 73 miRNAs detected in urinary EVs (NGT) were predicted to target important functions for kidney homoeostasis, thereby validating their use as indicators of kidney dysfunction...
August 27, 2018: Diabetes & Metabolism
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