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Diabetes & Metabolism

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https://www.readbyqxmd.com/read/28918195/impact-of-body-mass-index-and-metabolic-phenotypes-on-coronary-artery-disease-according-to-glucose-tolerance-status
#1
K Fujihara, Y Matsubayashi, M Yamamoto, T Osawa, M Ishizawa, M Kaneko, S Matsunaga, K Kato, H Seida, N Yamanaka, S Kodama, H Sone
OBJECTIVE: This study aimed to examine the impact of obesity, as defined by body mass index (BMI), and a metabolically unhealthy phenotype on the development of coronary artery disease (CAD) according to glucose tolerance status. METHODS: This population-based retrospective cohort study included 123,746 Japanese men aged 18-72years (normal glucose tolerance: 72,047; prediabetes: 39,633; diabetes: 12,066). Obesity was defined as a BMI≥25kg/m(2). Metabolically unhealthy individuals were defined as those with one or more of the following conditions: hypertension, hypertriglyceridaemia and/or low HDL cholesterol...
September 14, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28916390/il-33-receptor-st2-deficiency-attenuates-renal-ischaemia-reperfusion-injury-in-euglycaemic-but-not-streptozotocin-induced-hyperglycaemic-mice
#2
M Sehnine, M Ferhat, S Sena, J M Gombert, J M Goujon, A Thierry, G Touchard, T Hauet, A Herbelin, S Hadjadj
AIM: Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus, the present study examined the impact of genetic IL-33 receptor ST2 deficiency (ST2-/-) on renal IRI in euglycaemic and hyperglycaemic mice. METHODS: Hyperglycaemia was induced with streptozotocin (STZ) in adult male C57BL/6JRj wild-type (WT) mice and ST2-/- mice...
September 12, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28918929/vitamin-d-receptor-targeted-treatment-to-prevent-pathological-dedifferentiation-of-pancreatic-%C3%AE-cells-under-hyperglycaemic-stress
#3
A Neelankal John, Z Iqbal, S Colley, G Morahan, M Makishima, F-X Jiang
Dedifferentiation has been identified as one of the causes of β-cell failure resulting in type 2 diabetes (T2D). This study tested whether increasing vitamin D receptor (VDR) expression prevents dedifferentiation of β cells in a high-glucose state in vitro. Culturing a mouse insulinoma cell line (MIN6) in a high-glucose environment decreased VDR expression. However, increased VDR following vitamin D3 (VD3) treatment improved insulin release of early-passage MIN6 and insulin index of db/- (heterozygous) islets to levels seen in normal functional islets...
September 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28865748/circulating-pcsk9-levels-in-acute-coronary-syndrome-results-from-the-pc-sca-9-prospective-study
#4
B Cariou, P Guérin, C Le May, V Letocart, L Arnaud, B Guyomarch, M Pichelin, V Probst
BACKGROUND: Serum proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations have been shown to be positively associated with LDL cholesterol (LDL-C), but the relationship between PCSK9 and coronary atherosclerosis lesions remains unclear. OBJECTIVE: This study aims to investigate the correlation between serum PCSK9 levels and coronary damage severity in patients hospitalized for acute coronary syndrome (ACS). METHODS: In this prospective proof-of-concept study, coronary lesions were assessed using SYNTAX scores...
August 30, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28847680/the-association-between-handgrip-strength-and-sleep-duration-in-japanese-patients-with-type-2-diabetes
#5
LETTER
H Hamasaki
No abstract text is available yet for this article.
August 25, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28838743/total-serum-bilirubin-and-8-year-incident-type-2-diabetes-mellitus-the-korean-genome-and-epidemiology-study
#6
Y-J Kwon, Y-J Lee, B-J Park, K-W Hong, D-H Jung
AIM: In this study, the impact of serum bilirubin on new-onset type 2 diabetes mellitus (T2DM) in Korean adults was investigated. METHODS: Data were obtained from the Korean Genome and Epidemiology Study (KoGES), a population-based prospective cohort study. The study enrolled 8650 adults (4015 men and 4635 women), aged 40 to 69 years, who underwent a mean follow-up of 8.4 years. The study population was divided into quartiles (Q) of serum bilirubin levels, with cut-off points at 0...
August 21, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28822618/the-impact-of-incident-depression-on-medication-adherence-in-patients-with-type-2-diabetes
#7
C Lunghi, A Zongo, J Moisan, J-P Grégoire, L Guénette
BACKGROUND: Depression has been correlated with suboptimal adherence to antidiabetic drugs (ADs). Most studies on this topic were cross-sectional; thus, the directionality of this relationship could not be established. The objective of this study was to measure the association between incident depression and AD nonadherence among newly treated patients with diabetes. METHODS: We performed a population-based cohort study among new AD users using the Quebec public health insurance data...
August 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28778564/comparison-of-hepatocellular-carcinoma-risk-between-patients-treated-with-glimepiride-and-gliclazide
#8
LETTER
J-Y Lee, G Kim, Y-H Lee, B-W Lee, B-S Cha, C M Nam, E S Kang
No abstract text is available yet for this article.
August 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28778563/dipeptidyl-peptidase-4-inhibitors-and-risk-of-arthralgia-a-systematic-review-and-meta-analysis
#9
REVIEW
P Men, N He, C Song, S Zhai
BACKGROUND: The US Food and Drug Administration has warned that treatment with dipeptidyl peptidase (DPP)-4 inhibitors may promote serious arthralgia. However, the clinical evidence for this is relatively lacking. OBJECTIVE: For this reason, a systematic review and meta-analysis of randomized controlled trials (RCTs) were carried out to determine the relationship between DPP-4 inhibitors and risk of arthralgia, and also to investigate any potential risk factors...
August 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28774785/heart-rate-variability-in-fetuses-of-type-1-diabetes-pregnancies
#10
LETTER
Y Hamoud, J de Jonckheere, A Vambergue, V Houfflin-Debarge, L Storme, M Flocteil, P Deruelle, C Garabedian
No abstract text is available yet for this article.
July 31, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28774784/serum-soluble-trem2-is-a-potential-novel-biomarker-of-cognitive-impairment-in-japanese-non-obese-patients-with-diabetes
#11
LETTER
M Tanaka, H Yamakage, S Masuda, T Inoue, R Ohue-Kitano, R Araki, Y Matoba, M Saito, T Nagaoka, K Yonezawa, T Tanaka, M Suzuki, M Sawamura, M Nishimura, S Odori, H Wada, K Kotani, T Kusakabe, A Shimatsu, K Hasegawa, N Satoh-Asahara
No abstract text is available yet for this article.
July 31, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28754263/clinical-inertia-and-its-impact-on-treatment-intensification-in-people-with-type-2-diabetes-mellitus
#12
REVIEW
G Reach, V Pechtner, R Gentilella, A Corcos, A Ceriello
Many people with type 2 diabetes mellitus (T2DM) fail to achieve glycaemic control promptly after diagnosis and do not receive timely treatment intensification. This may be in part due to 'clinical inertia', defined as the failure of healthcare providers to initiate or intensify therapy when indicated. Physician-, patient- and healthcare-system-related factors all contribute to clinical inertia. However, decisions that appear to be clinical inertia may, in fact, be only 'apparent' clinical inertia and may reflect good clinical practice on behalf of the physician for a specific patient...
July 25, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28751101/association-of-handgrip-strength-with-b-type-natriuretic-peptide-levels-and-cardiovascular-events-in-patients-with-type-2-diabetes
#13
LETTER
H Hamasaki
No abstract text is available yet for this article.
July 24, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28735930/brain-atrophy-in-ageing-estimating-effects-of-blood-glucose-levels-vs-other-type-2-diabetes-effects
#14
LETTER
E I Walsh, M Shaw, P Sachdev, K J Anstey, N Cherbuin
No abstract text is available yet for this article.
July 20, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#15
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28720342/severe-hypoglycaemia-is-a-major-predictor-of-incident-diabetic-retinopathy-in-japanese-patients-with-type-2-diabetes
#16
S Tanaka, R Kawasaki, S Tanaka-Mizuno, S Iimuro, S Matsunaga, T Moriya, S Ishibashi, S Katayama, Y Ohashi, Y Akanuma, H Sone, H Yamashita
AIM: Hypoglycaemia is a common complication in diabetes patients. However, its relationship with retinopathy has not been well documented in patients with type 2 diabetes (T2D). This study aimed to investigate the associations between hypoglycaemia and the incidence and progression of diabetic retinopathy (DR). METHODS: In this longitudinal cohort study, which was part of the Japan Diabetes Complications Study (JDCS), adult patients with T2D were recruited at 59 diabetes clinics across Japan...
July 15, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28709749/the-brown-fat-secreted-adipokine-neuregulin-4-is-decreased-in-gestational-diabetes-mellitus
#17
S Kralisch, A Hoffmann, J Kratzsch, M Blüher, M Stumvoll, M Fasshauer, T Ebert
AIMS: Neuregulin 4 has recently been recognized as a novel adipokine secreted by brown adipose tissue (BAT), with beneficial effects on murine insulin resistance and hepatic steatosis. Yet, thus far, neither regulation of neuregulin 4 in gestational diabetes mellitus (GDM) nor its longitudinal changes in the peripartum period have been elucidated. METHODS: Circulating neuregulin 4 levels were measured by ELISA in 74 women with GDM and 74 healthy, gestational-age-matched controls...
July 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28693962/the-impact-of-triglycerides-on-glucose-tolerance-lipotoxicity-revisited
#18
REVIEW
M Seghieri, D Tricò, A Natali
Elevated plasma triglycerides (TGs) are early key features of conditions associated with a dysregulation in glucose metabolism and may predict the development of type 2 diabetes (T2D) over time. Although the acute ingestion of lipid, either mixed with or shortly before the meal, is neutral or slightly beneficial on glucose tolerance, a short-term increase in plasma TGs induced by either an i.v. lipid infusion or a high-fat diet produces a deterioration of glucose control. Accordingly, chronic lowering of plasma TGs by fibrates improves glucose homeostasis and may also prevent T2D...
July 7, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28690125/carbamylation-is-a-competitor-of-glycation-for-protein-modification-in-vivo
#19
C Nicolas, S Jaisson, L Gorisse, F J Tessier, C Niquet-Léridon, P Jacolot, C Pietrement, P Gillery
AIM: Chronic kidney disease (CKD) and diabetes mellitus are two diseases that accelerate protein molecular ageing through carbamylation and glycation reactions, characterized by the binding of urea-derived isocyanic acid and of sugars on proteins, respectively. These two reactions target the same protein amino groups and, thus, compete with each other. Such competition may arise especially in diabetic patients with nephropathy. This study aimed to evaluate their potential competitive effects in vitro and under conditions reproducing CKD and/or diabetes in vivo...
July 6, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28687221/low-serum-c-reactive-protein-levels-predict-90-day-mortality-in-hypoglycaemic-patients
#20
LETTER
A Bonaventura, F Gallo, F Carbone, G Sacchi, L Liberale, F Dallegri, D Maggi, F Montecucco, R Cordera
No abstract text is available yet for this article.
July 4, 2017: Diabetes & Metabolism
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