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Endocrine Practice

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https://www.readbyqxmd.com/read/28225316/adverse-event-reporting-in-patients-treated-with-thyroid-hormone-extract
#1
Rupendra T Shrestha, Alan Malabanan, Bryan R Haugen, Elliott G Levy, James V Hennessey
OBJECTIVE: Thyroid hormone extract is used for the treatment of thyroid disorders but limited data exist on adverse events commonly noted by the physicians associated with this use. The purpose of this survey was to report adverse events observed by expert physicians managing patients treated for thyroid disease with thyroid hormones. METHODS: Members of the American Thyroid Association, The Endocrine Society and the American Association of Clinical Endocrinologists developed a survey instrument modeled on the FDA's reported adverse events for levothyroxine that would effectively assess the clinical experience of frequent prescribers of thyroid hormone...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225315/improving-glycemic-control-safely-in-critical-care-patients-a-collaborative-systems-approach-in-nine-hospitals
#2
Gregory A Maynard, Janet Holdych, Heather Kendall, Karen Harrison, Patricia A Montgomery, Kristen Kulasa
Objective Safely improve glycemic control in the critical care units of nine hospitals. Methods Critical care adult inpatients from nine hospitals with ≥ 4 point-of-care (POC) blood glucose (BG) readings over ≥ 2 days were targeted by collaborative improvement efforts to reduce hyper- and hypo-glycemia. Balanced glucometric goals for each hospital were set targeting improvement from baseline, or goals deemed desirable from Society of Hospital Medicine (SHM) benchmarking data. Collaborative interventions included standardized insulin infusion protocols, hypoglycemia prevention bundles, audit and feedback, education, and measure-vention (coupling measurement of patients "off protocol" with concurrent interventions to correct suboptimal care)...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225314/the-prevalence-of-colonic-polyps-in-patients-with-acromegaly-a-case-control-nested-in-a-cohort-colonoscopic-study
#3
Baldomero Gonzalez, Guadalupe Vargas, Victoria Mendoza, Mariana Nava, Moisés Rojas, Moisés Mercado
BACKGROUND: Acromegaly is associated with an increased risk of colonic polyps. The magnitude of such risk is controversial and the characteristics that distinguish patients who develop polyps from those who do not are not well established. OBJECTIVE: To determine the prevalence of colonic polyps upon the diagnosis of acromegaly. To compare the clinical and biochemical features of patients with and without polyps Patients and methods: Out of 165 patients who underwent a full colonoscopy upon diagnosis of acromegaly, 53 were found to harbor colonic lesions (cases), whereas the remaining 112 conformed the group of controls...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225313/efficacy-and-safety-of-a-new-topical-testosterone-replacement-gel-therapy-for-the-treatment-of-male-hypogonadism
#4
Glenn Cunningham, Laurence Belkoff, Gerald Brock, Mitchell Efros, Marc Gittelman, Dario Carrara, Anders Neijber, Masakazu Ando, Jules Mitchel
OBJECTIVE: Testosterone replacement therapy is indicated for male hypogonadism. This study aimed to evaluate the efficacy and safety of Testosterone gel 2% (Tgel) over 90-days. METHODS: This phase 3, open-label, non-comparator study was conducted in adult hypogonadal men (two consecutive fasting serum testosterone values <300 ng/dL and >86% subjects with symptoms consistent with testosterone deficiency). Subjects applied Tgel 23 mg/day (single pump-actuation using hands-free cap applicator)...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225312/perspectives-on-learning-and-clinical-practice-improvement-for-diabetes-in-the-hospital-a-review-of-educational-interventions-for-providers
#5
Ariana Pichardo-Lowden, Paul Haidet, Guillermo E Umpierrez
BACKGROUND: The management inpatient hyperglycemia and diabetes requires expertise among many healthcare providers. There is limited evidence about how education for healthcare providers can result in optimization of clinical outcomes. The purpose of this critical review of the literature is to examine methods and outcomes related to educational interventions regarding the management of diabetes and dysglycemia in the hospital setting. This report provides recommendations to advance learning, curricular planning and clinical practice...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225311/prognostic-factors-for-survival-of-men1-patients-with-duodenopancreatic-tumors-metastatic-to-the-liver-results-from-the-dmsg-study-group
#6
Elfi B Conemans, Sjoerd Nell, Carolina R C Pieterman, Wouter W de Herder, Olaf M Dekkers, Ad R Hermus, Anouk N van der Horst-Schrivers, Peter H Bisschop, Bas Havekes, Madeleine L Drent, Menno R Vriens, Gerlof D Valk
Objective Duodenopancreatic neuroendocrine tumors (DP-NETs) develop in a majority of patients with Multiple Endocrine Neoplasia Type 1 (MEN1) and are the leading cause of death. Overall survival (OS) and prognostic factors for patients with liver metastases from DP-NETs are not known. Design and Methods Cohort study using the Dutch National MEN1 database, which includes >90% of the Dutch MEN1 population between 1990-2014. OS was assessed with time to event analysis, and prognostic factors were evaluated...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225310/central-diabetes-insipidus-clinical-characteristics-and-long-term-course-in-a-large-cohort-of-adults
#7
Hiba Masri-Iraqi, Dania Hirsch, Dana Herzberg, Avner Lifshitz, Gloria Tsvetov, Carlos Benbassat, Ilan Shimon
Purpose Central diabetes insipidus (CDI) is a rare heterogeneous condition with various underlying causes. This study sought to increase the still-limited data on the clinical characteristics and long-term course in adults diagnosed with CDI. Methods Data on demographics, presentation, imaging findings, affected pituitary axes, treatment, and complications were collected retrospectively from the files of 70 adult patients with CDI followed at a referral endocrine clinic. Results 40 women and 30 men were included...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225309/anabolic-bone-window-with-weekly-teriparatide-therapy-in-post-menopausal-osteoporosis-a-pilot-study
#8
Vinaya Gopalaswamy, Deba Prasad Dhibar, Vipin Gupta, Ashutosh Kumar Arya, Niranjan Khandelwal, Anil Bhansali, Sudhir Kumar Garg, Neelam Agarwal, Sudhaker D Rao, Sanjay Kumar Bhadada
BACKGROUND: Osteoporosis is a major public health problem, which reduces bone strength and increases risk of fracture. Teriparatide is an established and the only currently available anabolic therapy for the treatment of postmenopausal osteoporosis (PMO) with recommended daily dose of 20 μg subcutaneously. However data regarding the long term effect of once-weekly teriparatide therapy on bone mineral density (BMD), bone turnover markers (BTMs) and anabolic bone window is limited. METHODS: In this prospective observational study, 26 patients with PMO were treated with weekly teriparatide therapy (60 μg) for 2 years...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225308/visual-vignette
#9
Aaron Pardini
No abstract text is available yet for this article.
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225307/17a-hydroxylase-17-20-lyase-deficiency-clinical-and-molecular-characterization-of-eight-chinese-patients
#10
Chaoming Wu, Shanshan Fan, Yanying Qian, Yingying Zhou, Jian Jin, Zhijuan Dai, Ling Jiang
BACKGROUND: 17α-hydroxylase/17, 20-lyase deficiency (17OHD) is caused by mutations in CYP17A1 gene. OBJECTIVE: To better understand 17OHD, a rare disease, we described the clinical features and analyzed the CYP17A1 gene in eight affected Chinese patients. METHODS: Patients with complete (7/8) or partial (1/8) 17OHD were derived from six families. The diagnosis was established according to their clinical, biochemical, hormonal and radiological characteristics...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225306/hydrocortisone-therapy-and-growth-trajectory-in-children-with-classical-congenital-adrenal-hyperplasia
#11
Carla Bizzarri, Nicola Improda, Chiara Maggioli, Donatella Capalbo, Silvia Roma, Ottavia Porzio, Mariacarolina Salerno, Marco Cappa
OBJECTIVE: Poor linear growth is one of the main concerns in children with congenital adrenal hyperplasia (CAH). We aimed to analyze factors affecting growth trajectory in children with classical CAH. METHODS: Clinical records of children followed from infancy up to the end of growth at two Italian tertiary referral hospitals were reviewed. Fifty-seven patients (31 males), treated with hydrocortisone and fludrocortisone only, were included. Clinical observations were divided into 3 groups: 0-2 years: 172 observations; from 2 years to puberty onset: 813 observations; after puberty onset: 527 observations...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225305/limited-carbohydrate-refeeding-instruction-for-long-term-weight-maintenance-following-a-ketogenic-very-low-calorie-meal-plan
#12
J J Chang, J Bena, S Kannan, J Kim, B Burguera, S R Kashyap
OBJECTIVE: Weight loss maintenance following very-low-calorie meal plans is poorly studied. This report describes weight loss efficacy and predictors of weight loss maintenance of a ketogenic, very-low-calorie meal plan (protein-sparing modified fast, PSMF) in people with obesity. METHODS: 127 consecutive adults in the PSMF meal plan (27.2 ±19.5 weeks) and 48 adults on a conventional, hypocaloric meal plan (23.6 ±20.8 weeks) were retrospectively studied for percent weight change from baseline to end of intervention and at 6, 12, and 24 months post-intervention...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28156157/time-to-get-serious-about-insulin-timing
#13
Jeremy Pettus
No abstract text is available yet for this article.
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28156156/hyperglycemia-and-hypoglycemia-in-patients-with-diabetes-in-skilled-nursing-facilities
#14
Rushad Patell, Denis Nigmatoulline, James Bena, Do Gyun Kim, Barbara Messinger-Rapport, M Cecilia Lansang
BACKGROUND: Endocrinologists are faced with a growing elderly patient population with diabetes (DM), some of whom are in skilled nursing facilities (SNF). Efforts at managing their DM is hampered by concerns for hypoglycemia. This study aimed to determine the frequency of hypo- and hyperglycemia in SNFs, and associated factors. METHODS: We reviewed medical records of 200 consecutive residents admitted to 2 SNFs in the Cleveland area in 2014 with documented DM, aged ≥ 65 years...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28156155/assessment-of-diastolic-dysfunction-arterial-stiffness-and-carotid-intima-media-thickness-in-patients-with-acromegaly
#15
Güven Barış Cansu, Nusret Yılmaz, Atakan Yanıkoğlu, Sebahat Özdem, Aytül Belgi Yıldırım, Gültekin Süleymanlar, Hasan Ali Altunbaş
OBJECTIVE: Early diagnosis and treatment of cardiovascular diseases, the most frequent cause of morbidity and mortality in acromegaly, may be an efficient approach to extending the lifespan of the affected patients. Therefore, it is crucial to determine any cardiovascular diseases in the subclinical period. The study objectives were to determine markers of subclinical atherosclerosis and asses heart structure and functioning. METHODS: This was a cross-sectional single-center study in 53 patients with acromegaly and 22 age- and sex-matched healthy individuals...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28156154/insulin-timing-a-patient-centered-approach-to-improve-control-in-type-1-diabetes
#16
Elizabeth Duran-Valdez, Mark R Burge, Paula Broderick, Lynda Shey, Virginia Valentine, Ronald M Schrader, David S Schade
PURPOSE OF STUDY: The goal of insulin therapy in type 1 diabetes is to reduce A1C to ≤ 7.0% with minimal hypoglycemia. We investigated the possibility that "insulin timing" would improve A1C without incurring severe hypoglycemia in volunteers with T1D over a 6 month observation period. METHODS: Forty healthy adult volunteers with T1D were randomly assigned for six months to one of two groups: a control group or an insulin timing group. The primary endpoint was the difference in A1C between the two groups...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28156153/should-multifocal-papillary-thyroid-carcinomas-classified-as-t1a-having-the-sum-of-tumor-diameters-1-2-centimeter-be-reclassified-as-t1b
#17
Abbas Ali Tam, Didem Ozdemir, Berna Evranos Ogmen, Sevgul Fakı, Ersin Gurkan Dumlu, Aylin Kılıc Yazgan, Reyhan Ersoy, Bekir Cakır
OBJECTIVE: Considering the diameter of the largest tumor while determining T stage in multifocal papillary thyroid microcarcinomas (PTMC) might cause underestimation of tumoral stage. We aimed to investigate the effect of total tumor diameter (TTD) on TNM classification in multifocal T1a PTMCs. METHODS: T1 tumors were grouped as T1a and T1b according to 7th TNM edition. For patients with multifocal T1a, TTD (the sum of the maximal diameter of each foci) was calculated and these patients were further subgrouped as TTD ≤1 cm and TTD 1-2 cm...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28156152/relationship-between-serum-leptin-levels-and-weight-gain-in-girls-with-central-precocious-puberty-at-a-1year-follow-up
#18
Jessie N Zurita-Cruz, Miguel A Villasís-Keever, Leticia Damasio-Santana, Leticia Manuel-Apolinar, Elisa Nishimura-Meguro, Aleida de J Rivera-Hernández, Eulalia Garrido-Magaña, Alejandro Gutierrez-Gonzalez, Adriana Poblano-Alcalá
BACKGROUND AND OBJECTIVES: Patients with central precocious puberty (CPP) may have increased serum leptin levels; however, it is not well known whether this increase differs between patients with and without obesity. Our objectives were to describe the changes in serum leptin in girls with CPP in the first 12 months after diagnosis based on BMI and to explore whether serum leptin level at CPP diagnosis is related to BMI z-score (BMIz) after a one-year follow-up. DESIGN: A prospective cohort study was performed...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28156151/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-atherosclerosis
#19
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Each Recommendation is based on a diligent review of the clinical evidence with transparent incorporation of subjective factors. RESULTS: The Executive Summary of this document contains 87 Recommendations of which 45 are Grade A (51...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28156150/the-dark-side-to-dopamine-agonist-therapy-in-rolactinoma-management
#20
Sonia Ananthakrishnan
No abstract text is available yet for this article.
February 3, 2017: Endocrine Practice
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