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Endocrine Practice

Muyesser Sayki Arslan, Mustafa Sahin, Melia Karakose, Esra Tutal, Oya Topaloglu, Bekir Ucan, Taner Demirci, Mustafa Caliskan, Seyda Sahingol, Mustafa Ozbek, Erman Cakal
PURPOSE: The aim of this study to was to evaluate the effect of fibroblast growth factor-23 (FGF-23), osteoprotegerin (OPG), receptor activator nuclear kB ligand (RANKL), and vitamin D hormones on bone loss in patients with hyperprolactinemia due to the pituitary prolactinoma. METHODS: 46 premenopausal female patients with prolactinoma and age and sex matched healthy controls (Group 3, n=20) were recruited to this cross sectional study. Prolactinoma patients were divided into two groups as patients newly diagnosed (Group 1, n=26), and under cabergoline treatment (Group 2, n=20)...
November 16, 2016: Endocrine Practice
Ishita Singh, Athanasios Bikas, Carlos A Garcia, Sameer Desale, Leonard Wartofsky, Kenneth D Burman
Background 18F-FDG- PET/CT scans are used in high-risk thyroid cancer patients to determine the presence of metastasis. The prognostic significance of increases in SUVs (Standard Unit Values) has not been clearly defined. This pilot study investigated the correlation between increases in SUV with subsequent changes in size of individual lesions. Methods A retrospective chart review of patients with histologically confirmed thyroid cancer, monitored with serial 18F-FDG- PET/CT scans from 2008 to 2013, was performed...
November 16, 2016: Endocrine Practice
Patricia Mejia Osuna, Mary D Ruppe, Laila S Tabatabai
CONTEXT: A well-recognized gap exists between evidence-based recommendations for post-fracture care and actual clinical practice, demonstrated by the high percentage of fragility fracture patients who are neither diagnosed nor treated for osteoporosis. Our purpose is to review fracture liaison service (FLS) models and to evaluate national and international experiences in secondary fracture prevention. EVIDENCE ACQUISITION: We performed a systematic search of publication databases (MEDLINE, SCOPUS) and included randomized controlled trials, meta-analyses and review articles using the following keywords: Fracture liaison services, Secondary prevention of fracture, Post-fracture health care gap and Fragility fractures...
November 16, 2016: Endocrine Practice
Chase D Hendrickson, Saumya Saini, Avin Pothuloori, John N Mecchella
OBJECTIVE: Outpatient specialty consultations rely on the timeliness and completeness of referral information to facilitate a valuable patient-specialist interaction. This project aimed to increase essential diagnostic information availability at the initial consultation for patients referred for common endocrine conditions frequently lacking such data - diabetes mellitus, thyroid nodule, thyrotoxicosis, and hypercalcemia. METHODS: At an endocrinology clinic at an academic medical center in rural New England, providers see several thousand new patients annually, the majority of whom are referred by providers external to the clinic's healthcare system...
November 16, 2016: Endocrine Practice
Anette Merke, Jürgen Merke, Guenther Silbernagel, Winfried März
TITLE: Free Thyroid Hormones and Mortality in Caucasians undergoing Angiography: The LUdwigshafen RIsk and Cardiovascular Health Study (LURIC) Objective: Alterations in thyroid hormone functions are associated with mortality and morbidity. Data on euthyroid individuals are very limited and controversial. We therefore investigated the relationship between circulating thyroid hormones and all-cause and cardiovascular (CV) mortality in participants of the LURIC study and their association with morbidity...
November 16, 2016: Endocrine Practice
Scott James Steven, Khuram Kazmi, Ajay Kohli, Barbara Simon
No abstract text is available yet for this article.
November 16, 2016: Endocrine Practice
Karl Z Nadolsky
No abstract text is available yet for this article.
November 16, 2016: Endocrine Practice
Ella Ekholm, Lars Hansen, Eva Johnsson, Nayyar Iqbal, Björn Carlsson, Hungta Chen, Boaz Hirshberg
OBJECTIVE: To determine if reduction in serum insulin with dapagliflozin plus saxagliptin or dapagliflozin add-on to metformin contributed to increased insulin clearance and to assess the effects of these treatments on β-cell function. METHODS: Patients (A1C 8.0%-12.0%) were randomized to 24-week, double-blind treatment with saxagliptin 5 mg/d plus dapagliflozin 10 mg/d (n=179), saxagliptin 5 mg/d plus placebo (n=176), or dapagliflozin 10 mg/d plus placebo (n=179) added to metformin...
November 16, 2016: Endocrine Practice
Jacqueline L Cartier, Subhash C Kukreja, Elena Barengolts
Objective The study examined whether vitamin D insufficiency is a predictor of prevalent and/or incident common chronic conditions in African American men (AAM) and Caucasian men (CAM). Methods 1,017 men were recruited at an urban VA medical center and followed prospectively for a mean of 5.4 years. Prevalent and incident chronic conditions evaluated were: obesity, type 2 diabetes (T2D), cancer, depression, dementia, and cardiovascular disease (CVD, including coronary artery disease [CAD], cerebrovascular accident [CVA], and congestive heart failure [CHF])...
November 16, 2016: Endocrine Practice
Aidan McElduff
No abstract text is available yet for this article.
November 16, 2016: Endocrine Practice
Poupak Fallahi, Silvia Martina Ferrari, Alessandro Antonelli
OBJECTIVE: Levothyroxine (L-T4) is the standard therapy of hypothyroidism. Our purpose is to compare the effectiveness of L-T4 liquid formulation, with respect to L-T4 tablet, in hypothyroid patients without malabsorption or drug interference. METHODS: Twentyone subjects with high thyroid-stimulating hormone (TSH) values under therapy with L-T4 tablets were switched to liquid L-T4 at the same dosage, 30 minutes before breakfast. RESULTS: TSH values significantly declined after 2 months from the switch to liquid L-T4, reaching in most cases the normal range...
November 16, 2016: Endocrine Practice
Yair Liel
OBJECTIVE: Late onset hypogonadotropic hypogonadism (LOH) is a complex, heterogeneous entity. Whenever treatment is indicated, the endocrine literature has recommend testosterone replacement. We present our experience with clomiphene citrate (CC) treatment in patients with LOH and a review of the literature. DESIGN: A retrospective case series. PATIENTS AND MEASUREMENTS: Eighteen male patients with hypogonadotropic hypogonadism, roughly according to the EMAS criteria for LOH, attended at an academic hospital outpatient clinic...
November 16, 2016: Endocrine Practice
Xiujuan Zhang, Jia Li, Xiaoming Zhou, Qingbo Guan, Jiajun Zhao, Ling Gao, Chunxiao Yu, Yong Wang, Changting Zuo
AIM: Statins can inhibit the rate limiting enzyme HMG-CoA reductasein to reduce cholesterol biosynthesis and they are used frequently in the clinic. Cholesterol is also known as precursor material used to produce the sex hormones. However, it is not clear whether statins can affect sex hormone levels or not. The aim of this study is to investigate the effect of long-term use of statins on sex hormone levels in vivo. METHODS: Forty male SD rats were randomly divided into 4 groups...
November 16, 2016: Endocrine Practice
Yehuda Handelsman, Michael D Shapiro
Despite improved atherosclerotic cardiovascular disease (ASCVD) outcomes with statin therapy, residual risk remains. Recent genetic insights provide further compelling evidence that triglycerides are in the causal pathway for the development of atherosclerosis, thereby renewing interest in targeting triglycerides to improve ASCVD outcomes. Fibrates, niacin, and omega-3 fatty acids (OM3FAs) are 3 classes of triglyceride-lowering drugs. Outcome studies with triglyceride-lowering agents have been inconsistent...
November 7, 2016: Endocrine Practice
Lindsay M Arnold, Mufaddal Mahesri, Marie E McDonnell, Sara M Alexanian
OBJECTIVE: While hyperglycemia in the postoperative setting has been linked to an increase in surgical complications, limited data is available to inform the management of patients with diabetes (DM) in the operating room and the immediate perioperative period. We describe the results of a perioperative glycemic control program that standardized intravenous insulin with a target glucose (BG) range of 120-180 mg/dL for patients with DM presenting with a BG level > 180mg/dL and included transition to subcutaneous insulin...
November 7, 2016: Endocrine Practice
Jawairia Shakil, Mohammed Z Ansari, Jett Brady, Jiaqiong Xu, Richard J Robbins
OBJECTIVE: Incidentally discovered thyroid cancers (IDTC) contribute to the rapid rise in thyroid cancer incidence over the past 20 years. Since death rates from thyroid cancer are not increasing, we hypothesized that IDTC are less aggressive compared to those whose cancers are clinically apparent (CATC). METHODS: A retrospective study of patient and tumor characteristics of IDTC and their rates of residual/recurrent (R/R) disease were determined at a median follow-up of 27 months in the setting of a large academic medical center...
November 7, 2016: Endocrine Practice
Pablo F Mora, Eric L Johnson
OBJECTIVE: Diabetes is a well-established pro-inflammatory state with an increased risk for cardiovascular (CV) diseases. In recent years, the number of different classes of agents for the treatment of type 2 diabetes has increased substantially, and while glycemic control is the major focus of these medications, CV safety has become of interest. Two incretin based therapies are currently available, glucagonlike peptide-1 (GLP-1) receptor agonists (RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors...
November 7, 2016: Endocrine Practice
Christopher R McHenry
No abstract text is available yet for this article.
November 7, 2016: Endocrine Practice
Ana E Espinosa De Ycaza, Tasha L Welch, Naykky Singh Ospina, Rene Rodriguez-Gutierrez, Thomas D Atwell, Dana Erickson, Irina Bancos
Objective Image guided thermal ablation of adrenal metastases has been increasingly used for local tumor control. This procedure has been associated with hypertensive urgency; however endocrine complications have not been clearly described. Our objective was to assess the hemodynamic behavior and risk for adrenal insufficiency related to adrenal ablation. Additionally, we sought to understand the utility of preprocedural α-blockade to prevent peri-procedural hemodynamic complications. Methods This is a retrospective study of patients undergoing image guided ablation of adrenal metastases between 2003 and 2015 at our institution...
November 7, 2016: Endocrine Practice
Keita Uchino, Masato Komoda, Junichi Tomomatsu, Takahiro Okamoto, Kiyomi Horiuchi, Akihito Tsuji, Yasuhiro Ito, Takuya Todo, Ki Rito, Shunji Takahashi
OBJECTIVE: In a Phase III trial, Western patients with medullary thyroid cancer (MTC) treated with the oral multikinase inhibitor vandetanib showed significantly improved progression-free survival (PFS) and objective response rate (ORR) compared with placebo. The biology of MTC and pharmacokinetics (PK) are similar for Japanese and Western patients; therefore, similar clinical benefit is anticipated in the Japanese population. This study evaluated the safety and tolerability of vandetanib in Japanese patients with unresectable locally advanced or metastatic MTC...
November 7, 2016: Endocrine Practice
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