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Endocrine Practice

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https://www.readbyqxmd.com/read/30106635/interpretation-of-unexpectedly-high-levels-of-endocrine-tumor-markers
#1
Run Yu
OBJECTIVE: Endocrine tumor markers (ETMs) are important and indispensable tools in the diagnosis and follow-up of endocrine tumors. Unexpectedly high level of ETM (UHLETM) is often encountered in clinical practice. The objectives of this article are to discuss the approach to UHLETMs and describe the most common UHLETMs. METHODS: Literature review and personal experience with UHLETMs. RESULTS: A UHLETM is defined as an ETM level much higher than what an endocrinologist would expect based on the patient's clinical information, other biochemical test results, and imaging findings...
August 14, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30106634/visual-vignette
#2
Geethu Antony, Hirenkumar Kamleshkumar, Shivendra Verma, Nitin Kapoor, Hesarghatta S Asha, Dincy Peter, Thomas V Paul
No abstract text is available yet for this article.
August 14, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30106633/a-case-of-propylthiouracil-ptu-induced-antineutrophil-cytoplasmic-antibody-anca-positive-cutaneous-vasculitis-in-a-hispanic-woman
#3
Sartaj S Sandhu, Sandeep S Dhindsa, Nitesh D Kuhadiya, Paresh Dandona
No abstract text is available yet for this article.
August 14, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30106631/multi-system-sarcoidosis-causing-panhypopituitarism-rapid-improvement-with-corticosteroid-therapy
#4
Rashid Mahboob, Ali A Rizvi
No abstract text is available yet for this article.
August 14, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30106630/a-combined-outpatient-and-inpatient-overnight-water-deprivation-test-is-effective-and-safe-in-diagnosing-patients-with-the-polyuria-polydipsia-syndrome
#5
William Pedrosa, Juliana Beaudette Drummond, Beatriz Santana Soares, Antônio Ribeiro-Oliveira
OBJECTIVES: The water deprivation test (WDT) is widely used for the differential diagnosis of the polyuria-polydipsia syndrome (PPS). However, it is inconvenient and may not always be precise in differentiating partial forms of diabetes insipidus (DI) from primary polydipsia (PP). The aim of this study was to evaluate the results of a combined outpatient and inpatient overnight WDT protocol that included an overnight non-supervised period concerning its feasibility and safety. METHODS: Retrospective analysis of clinical data and laboratory results of 52 patients with PPS undergoing WDT in a single center was undertaken...
August 14, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30106629/atypical-and-impending-femur-fractures-in-the-setting-of-long-term-bisphosphonate-use
#6
Sanaa Ayyoub, Christopher Coyne
No abstract text is available yet for this article.
August 14, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30106628/visual-vignette
#7
Harris M Baloch, Mohamed K Shakir, Thanh D Hoang
No abstract text is available yet for this article.
August 14, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084690/pathogenesis-of-cushing-disease-an-update-on-the-genetics-of-corticotropinomas
#8
Adriana Albani, Luis G Perez-Rivas, Martin Reincke, Marily Theodoropoulou
Cushing's disease is a rare severe condition caused by pituitary tumors that secrete ACTH leading to excessive endogenous glucocorticoid production. Tumors causing Cushing's disease, also called corticotropinomas, are typically monoclonal neoplasms that mainly occur sporadically. Cushing's disease is very rarely encountered in genetic familial syndromes. Oncogenes and tumor suppressor genes commonly associated with other tumor types are only rarely muted in this tumor type. The advent of next generation sequencing led to the identification of a single mutational hotspot in the ubiquitin-specific protease 8 ( USP8) gene in almost half of Cushing's disease tumors...
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084689/dexamethasone-stress-test-a-pilot-clinical-study-for-identification-of-individuals-highly-prone-to-develop-type-2-diabetes
#9
Nader Taheri, Ashraf Aminorroaya, Faramarz Ismail-Beigi, Massoud Amini
OBJECTIVE We examine whether "Dexamethasone Stress Test" exhibits the requisite high predictive ability to identify individuals highly prone to develop type 2 diabetes (T2DM). METHODS Seven years ago, we administered an oral glucose tolerance test (OGTT) to 33 individuals without T2DM and repeated the OGTT 24 h after a single oral dose of 8 mg dexamethasone (Dex); all participants had a first-degree relative with T2DM, and close to half had prediabetes. We calculated Receiver Operating Characteristic (ROC) curves for all parameters derived from the OGTT before and after Dex in individuals who subsequently developed diabetes compared to individuals who did not...
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084687/biochemical-responses-in-symptomatic-and-asymptomatic-patients-with-neuroendocrine-tumors-pooled-analysis-of-2-phase-3-trials
#10
Beloo Mirakhur, Marianne E Pavel, Rodney F Pommier, George A Fisher, Alexandria T Phan, Christine Massien, Nilani Liyanage, Susan Pitman Lowenthal, Aaron I Vinik
OBJECTIVE: Neuroendocrine tumors (NETs) are associated with elevated 5-hydroxyindoleacetic acid (5-HIAA) and chromogranin A (CgA) levels. This study aimed to analyze relationships between urinary 5-HIAA and plasma CgA levels and clinical outcomes. METHODS: Centrally assessed biomarker levels and correlations with progression-free survival (PFS) and carcinoid syndrome (CS) symptom control were evaluated in a pooled analysis of CLARINET (96-week randomized, double-blind, placebo-controlled) and ELECT (16-week randomized, double-blind, placebo-controlled, 32-week initial open-label and ≥ 2 year long term extension open label) studies of adults with NETs, with (ELECT) or without (CLARINET) CS at 97 institutions...
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084685/incidental-thyroid-nodules-race-ethnicity-disparities-and-outcomes
#11
Ayaka J Iwata, Arti Bhan, Sharon Lahiri, Amy M Williams, Charlotte Burmeister, Steven S Chang, Michael C Singer
OBJECTIVE: Black patients have a significantly lower incidence of well-differentiated thyroid cancer (WDTC) compared to all other race / ethnic groups, while white patients appear to be at greater risk. This study examines incidental thyroid nodules (ITNs) to assess whether racial disparities in WDTC arise from a differential discovery of ITNs perhaps due to socioeconomic disparities, or reflect true differences in thyroid cancer rates. METHODS: A retrospective review was performed of all patients who underwent fine needle aspiration of thyroid nodules by our academic medical center's endocrinology division between January 2006 and December 2010...
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084684/glucagon-like-peptide-1-receptor-agonists-for-type-2-diabetes-a-comprehensive-review-of-how-to-weigh-the-options-select-the-right-patients-and-maximize-benefits
#12
Lawrence Blonde, Vivian Fonseca
A growing body of data, guideline recommendations, algorithms, and position papers supports the use of glucagon-like peptide-1 (GLP-1) receptor agonists in type 2 diabetes (T2D), given their beneficial effects on glycemic control, weight, lipid parameters, and blood pressure, and low risk for hypoglycemia when used in patients who have not achieved glycemic goals with metformin and lifestyle interventions. Exciting new evidence continues to emerge, showing the utility of certain GLP-1 receptor agonists to decrease incident cardiovascular (CV) outcomes, and to bolster glycemic control when combined with other antihyperglycemic therapies, including basal insulin...
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084683/hyperpara-mod2
#13
Barry Sacks
No abstract text is available yet for this article.
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084681/a-novel-compound-heterozygous-variant-of-slc12a3-gene-in-a-pedigree-with-gitelman-syndrome-coexisted-with-thyroid-dysfunction
#14
Simo Liu, Jing Ke, Baoyu Zhang, Caiguo Yu, Yingmei Feng, Dong Zhao
OBJECTIVE: Gitelman syndrome (GS) is known as an autosomal recessive disorder characterized by salt wasting and hypokalemia resulting from mutations in the SLC12A3 (solute carrier family 12 member 3) gene, which codes the thiazide-sensitive Na-Cl cotransporter. To date, more than 488 mutations of the SLC12A3 gene have been discovered in patients with GS. In this study, we reported a GS pedigree complicated by thyroid diseases or thyroid dysfunction. METHODS: Sanger sequencing and next generation sequencing analysis were performed to determine the SLC12A3 gene mutations in a GS pedigree including the 16-year old male patient with GS and his family members within three generations...
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084679/clinical-characteristics-and-sequelae-of-severe-hypertriglyceridemia-in-pediatrics
#15
Trey Richardson, Stella Aslibekyan, Ambika P Ashraf
OBJECTIVE: Severe hypertriglyceridemia (HTG) (i.e., plasma triglycerides [TGs] >1,000 mg/dL) in children is a rare but pernicious and understudied condition. Our objective was to evaluate the etiology, characteristics, and sequelae of severe pediatric HTG. METHODS: This was a retrospective electronic medical record review of pediatric patients with severe HTG at a tertiary referral Children's hospital over a 17-year period. RESULTS: There were a total of 124 patients with severe HTG...
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084677/thyroseq-%C3%A2-v2-0-molecular-testing-a-cost-effective-approach-for-the-evaluation-of-indeterminate-thyroid-nodules
#16
Ana Marcella Rivas, Aziza Nassar, Jun Zhang, John D Casler, Ana Maria Chindris, Robert Smallridge, Victor Bernet
OBJECTIVE: Approximately 15 to 30% of thyroid nodules have indeterminate cytology. Many of these nodules are treated surgically, but only 5 to 30% are malignant. Molecular testing can further narrow the risk of malignancy of these nodules. Our objective was to assess the cost effectiveness of ThyroSeq® V2.0 compared to diagnostic thyroidectomy for the evaluation of indeterminate nodules. METHODS: Cytology and histopathology slides of Bethesda category III and IV (suspicious for follicular neoplasia [SFN]) nodules obtained between January 1, 2014 and November 30, 2016 were re-reviewed by 2 endocrine cytopathologists...
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084676/thyroid-disease-awareness-among-u-s-adults-with-hypothyroidism-1999-2014
#17
Kosuke Inoue, Angela M Leung
No abstract text is available yet for this article.
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30084675/a-rare-cause-of-acute-limb-pain-diabetic-muscle-infarction
#18
Yu Ji Kim, Kyung Ae Lee, Tae Sun Park, Heung Yong Jin
No abstract text is available yet for this article.
August 7, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30035626/the-management-of-hyperglycemia-in-noncritically-ill-hospitalized-patients-treated-with-continuous-enteral-or-parenteral-nutrition
#19
Kaitlyn C Vennard, Daryl J Selen, Matthew P Gilbert
Hyperglycemia is a common problem in hospitalized patients receiving artificial nutrition, and this development of hyperglycemia during parenteral nutrition therapy (PNT) and enteral nutrition therapy (ENT) increases the risk of hospital-related complications and mortality. This review aims to discuss the pathogenesis of hyperglycemia from artificial nutrition in the hospital, summarize current evidence on the treatment of hyperglycemia with insulin in these patients, and review current guidelines. A systematic literature review using PubMed and the Medical Subject Headings (MeSH) terms "hyperglycemia," "enteral nutrition," and "parenteral nutrition" were used to evaluate the current evidence available for treating non-critically ill patients with hyperglycemia who were receiving artificial nutrition...
July 23, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/30035625/parathyroid-cysts-a-rare-and-diagnostically-challenging-cause-of-neck-mass
#20
Pasquale Passarella, Hassan Shawa
No abstract text is available yet for this article.
July 23, 2018: Endocrine Practice
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