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Cellular & Molecular Biology Letters

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https://www.readbyqxmd.com/read/29760746/microrna-495-inhibits-the-high-glucose-induced-inflammation-differentiation-and-extracellular-matrix-accumulation-of-cardiac-fibroblasts-through-downregulation-of-nod1
#1
Xiaowei Wang, Haiying Jin, Shifeng Jiang, Yanlan Xu
Background: MicroRNAs (miRNAs) have physiological and pathophysiological functions that are involved in the regulation of cardiac fibrosis. This study aimed to investigate the effects of miR-495 on high glucose-induced cardiac fibrosis in human cardiac fibroblasts (CFs) and to establish the mechanism underlying these effects. Methods: Human CFs were transfected with an miR-495 inhibitor or mimic and incubated with high glucose. The levels of NOD1 and miR-495 were then determined via quantitative RT-PCR...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29760745/diagnostic-value-of-decoy-receptor-3-combined-with-procalcitonin-and-soluble-urokinase-type-plasminogen-activator-receptor-for-sepsis
#2
Jing-Jing Zhao, Xiao-Li Lou, Hong-Wei Chen, Feng-Ting Zhu, Yan-Qiang Hou
The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29760744/mst1-regulates-post-infarction-cardiac-injury-through-the-jnk-drp1-mitochondrial-fission-pathway
#3
Xisong Wang, Qing Song
Background: Post-infarction cardiac injury is closely associated with cardiac remodeling and heart dysfunction. Mammalian STE20-like kinase 1 (Mst1), a regulator of cellular apoptosis, is involved in cardiac remodeling in post-infarction heart, but the mechanisms remain poorly defined. We aimed to explore the role of Mst1 in regulating chronic post-infarction cardiac injury, with a focus on mitochondrial homoeostasis. Methods: Wild-type (WT) and Mst1-knockout mice were as the cardiac myocardial infarction model...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29760743/crosstalk-between-the-warburg-effect-redox-regulation-and-autophagy-induction-in-tumourigenesis
#4
REVIEW
Mokgadi Violet Gwangwa, Anna Margaretha Joubert, Michelle Helen Visagie
Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ago. Furthermore, increased reactive oxygen species (ROS) and lactate quantities increase metabolic, survival and proliferation signalling, resulting in increased tumourigenesis. In order to maintain redox balance, the cell possesses innate antioxidant defence systems such as superoxide dismutase, catalase and glutathione...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29743895/osthole-improves-collagen-induced-arthritis-in-a-rat-model-through-inhibiting-inflammation-and-cellular-stress
#5
Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang, Ming Yang
Background: Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored. In the present study, a collagen-induced arthritis rat model, IL-1β-stimulated SW982 cells, and RA-like fibroblast-like synoviocytes (FLS) were employed to investigate the effect and possible mechanism of osthole on arthritis in vivo and in vitro. Results: 20 and 40 mg/kg osthole significantly alleviated collagen-induced arthritic symptoms based on histopathology and clinical arthritis scores, and improved erosion using HE staining...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29743894/lycium-barbarum-polysaccharide-protects-hsf-cells-against-ultraviolet-induced-damage-through-the-activation-of-nrf2
#6
Bihua Liang, Liqian Peng, Runxiang Li, Huaping Li, Ziyin Mo, Xinyue Dai, Na Jiang, Qing Liu, Erting Zhang, Huiyan Deng, Zhenjie Li, Huilan Zhu
Background: Lycium barbarum polysaccharide (LBP) is considered an antioxidant agent. NF-E2-related factor-2 (Nrf2) is an important regulator for protection against UV damage. In this study, we verified the performance of LBP and the correlation between LBP and Nrf2. Methods: HSF cells were treated with LBP to determine dose and time dependencies. An antioxidant response element (ARE) reporter was designed to monitor the activity of the Nrf2 antioxidant pathway. Results: For HSF cells, the optimal LBP treatment was 300 μg/ml for 3 h...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29736176/knockdown-of-the-lncrna-snhg8-inhibits-cell-growth-in-epstein-barr-virus-associated-gastric-carcinoma
#7
Jing Liu, Chunxia Yang, Yufang Gu, Chong Li, Huamei Zhang, Wenfang Zhang, Xueqing Wang, Nan Wu, Chunyan Zheng
Background: Epstein-Barr virus (EBV) infection is causatively associated with a variety of human cancers, including gastric cancer (GC), which has one of the highest mortality rates of all human cancers. Long non-coding RNAs (lncRNAs) show important regulatory roles in human GC. SNHG8 is a recently identified lncRNA that was reported to show abnormal expression pattern in GC. However, little is known of its biological function in EBV-associated GC. Methods: We used cell viability, colony formation and cell cycle assays to investigate the roles of lncRNA SNHG8 in the cell growth of EBV-associated GC...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29721023/mirna-17-encoded-by-the-mir-17-92-cluster-increases-the-potential-for-steatosis-in-hepatoma-cells-by-targeting-cyp7a1
#8
Ruijie Gong, Xiaofei Lv, Fengqiong Liu
Background: The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers. Members of this cluster were also found to be involved in some other pathological process, such as steatosis, which is a pivotal event in the initiation and progression of nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether miR-17, one of the most functional miRNAs in the miR-17-92 family, participates in the process of steatosis in hepatoma cells. Methods: We developed both a miR-17-expressing transgenic mouse model and a miR-17-expressing HepG2 cell model, the latter was established via stable transfection...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29713353/the-norpurpureine-alkaloid-from-annona-purpurea-inhibits-human-platelet-activation-in-vitro
#9
Gabriela Sánchez, Omar Estrada, Giovana Acha, Alfonso Cardozo, Franshelle Peña, Marie Christine Ruiz, Fabián Michelangeli, Claudia Alvarado-Castillo
Background: The leaves of Annona purpurea have yielded several alkaloids with anti-aggregation activities against rabbit platelets. This is promising in the search for agents that might act against platelets and reduce the incidence of cardiovascular diseases. Since significant differences in platelet function have been reported between human and animal platelets, a study focusing on the effect of A. purpurea extracts against human platelet activation is necessary. Methods: The compounds in an A...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29636771/mitochonic-acid-5-activates-the-mapk-erk-yap-signaling-pathways-to-protect-mouse-microglial-bv-2-cells-against-tnf%C3%AE-induced-apoptosis-via-increased-bnip3-related-mitophagy
#10
Qingyun Lei, Jian Tan, Shangqing Yi, Na Wu, Yilin Wang, Heng Wu
Background: The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, we investigated the protective role of mitochonic acid 5 (MA-5) in microglial mitochondrial apoptosis following TNFα-induced inflammatory injury. Methods: TNFα was used to induce inflammatory injury in mouse microglial BV-2 cells with and without prior MA-5 treatment...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29610575/arsenic-trioxide-induces-apoptosis-and-the-formation-of-reactive-oxygen-species-in-rat-glioma-cells
#11
Yuanyuan Sun, Chen Wang, Ligang Wang, Zhibo Dai, Kongbin Yang
Background: Arsenic trioxide (As2 O3 ) has a dramatic therapeutic effect on acute promyelocytic leukemia (APL) patients. It can also cause apoptosis in various tumor cells. This study investigated whether As2 O3 has an antitumor effect on glioma and explored the underlying mechanism. Results: MTT and trypan blue assays showed that As2 O3 remarkably inhibited growth of C6 and 9 L glioma cells. Cell viability decreased in glioma cells to a greater extent than in normal glia cells...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29588647/stat3-stem-cells-cancer-stem-cells-and-p63
#12
REVIEW
Michaela Galoczova, Philip Coates, Borivoj Vojtesek
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem cells. p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29568314/platelet-lysate-induces-chondrogenic-differentiation-of-umbilical-cord-derived-mesenchymal-stem-cells
#13
Ghmkin Hassan, Mohammad Bahjat, Issam Kasem, Chadi Soukkarieh, Majd Aljamali
Purpose: Articular cartilage has a poor capacity for self-repair, and thus still presents a major challenge in orthopedics. Mesenchymal stem cells (MSCs) are multipotent stem cells with the potential to differentiate into chondrocytes in the presence of transforming growth factor beta (TGF-β). Platelet lysate (PL) contains a relatively large number of growth factors, including TGF-β, and has been shown to ameliorate cartilage repair. Here, we investigated the ability of PL to direct chondrogenic differentiation of MSCs along with other standard differentiation components in a pellet culture system...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29568313/the-in-vitro-effects-of-a-novel-estradiol-analog-on-cell-proliferation-and-morphology-in-human-epithelial-cervical-carcinoma
#14
Laura Susan Boyd, Devrim Gozuacik, Anna Margaretha Joubert
Background: The majority of novel chemotherapeutics target the cell cycle, aiming to effect arrest and cause apoptosis. One such agent, 2-methoxyestradiol (2ME), has been shown to possess anticancer properties against numerous cancer types, both in vitro and in vivo. Despite its promise, 2ME has exhibited limitations, including low oral bioavailability and rapid hepatic enzymatic inactivation in vivo. A novel sulphamoylated estrogen analog, 2-ethyl-3- O -sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16), was in silico-designed in our laboratory to overcome these issues...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29563926/gsk-3%C3%AE-mediated-regulation-of-cadmium-induced-cell-death-and-survival
#15
Seungwoo Kim, Hyosoon Cheon, Sam-Moon Kim, Young-Youl Kim
Background: Previous studies indicated that cadmium (Cd) increases PI3-kinase/Akt phosphorylation, resulting in an alteration in GSK-3β activity. However, the mechanism of Cd-induced endoplasmic reticulum (ER) stress in neuronal cells has yet to be studied in needs further elucidation. We examined the role of GSK-3β in Cd-induced neuronal cell death and the related downstream signaling pathways. Methods: SH-SY5Y human neuroblastoma cells were treated with 10 or 20 μM BAPTA-AM and 1 μM wortmannin for 30 min and then incubated with 25 μM Cd for 12 h...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29483929/downregulation-of-microrna-448-inhibits-il-1%C3%AE-induced-cartilage-degradation-in-human-chondrocytes-via-upregulation-of-matrilin-3
#16
Hao Yang, Di Wu, Hua Li, Nan Chen, Yongjun Shang
Background: Osteoarthritis is characterized by the continuous degradation of the articular cartilage. The microRNA miR-448 has been found to be broadly involved in cellular processes, including proliferation, apoptosis, invasion and EMT. While aberrant expression of miR-448 has been found in multiple cancers, its level in osteoarthritis cartilage and its role in the progression of this disease are still unknown. Here, we examined the functional roles of miR-448 and its expression in osteoarthritis tissues, including IL-1β-stimulated osteoarthritis chondrocytes...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29483928/c-fos-upregulates-p-glycoprotein-contributing-to-the-development-of-multidrug-resistance-in-hep-2-laryngeal-cancer-cells-with-vcr-induced-resistance
#17
Guodong Li, Xiaoling Hu, Lu Sun, Xin Li, Jianfeng Li, Tongli Li, Xiaohui Zhang
Background: Laryngeal cancer tends to have a very poor prognosis due to the unsatisfactory efficacy of chemotherapy for this cancer. Multidrug resistance (MDR) is the main cause of chemotherapy failure. The proto-oncogene c-fos has been shown to be involved in the development of MDR in several tumor types, but few studies have evaluated the relationship between c-fos and MDR in laryngeal cancer. We investigated the role of c-fos in MDR development in laryngeal cancer cells (cell line: human epithelial type 2, HEp-2) using the chemotherapeutic vincristine (VCR)...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29456557/the-altered-expression-of-perineuronal-net-elements-during-neural-differentiation
#18
Nazli F Eskici, Sevim Erdem-Ozdamar, Didem Dayangac-Erden
Background: Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteoglycan link protein 1 (HAPLN1), tenascin-R (TNR) and aggrecan (ACAN) are key elements of PNNs. In diseases characterized by neuritogenesis defects, the expression of these proteins is known to be downregulated, suggesting that PNNs may have a role in neural differentiation...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29416550/the-wnt7b-%C3%AE-catenin-signaling-pathway-is-involved-in-the-protective-action-of-calcitonin-gene-related-peptide-on-hyperoxia-induced-lung-injury-in-premature-rats
#19
Shaohua Wang, Hongxing Dang, Feng Xu, Jian Deng, Xuemei Zheng
Background: Calcitonin gene-related peptide (CGRP) can protect against hyperoxia-induced lung injury, making the upregulation of CGRP a potential therapeutic approach for this type of injury. However, the effects of CGRP on the Wnt7b/β-catenin signaling pathway are unclear. In this study, we investigated the roles of CGRP and the Wnt7b/β-catenin signaling pathway in hyperoxia-induced lung injury. Methods: Premature Sprague Dawley (SD) rats were exposed to 21, 40, 60 and 95% oxygen for 3, 7 and 14 days...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29308069/orally-administered-endoxifen-inhibits-tumor-growth-in-melanoma-bearing-mice
#20
Paul Chen, Saifuddin Sheikh, Ateeq Ahmad, Shoukath M Ali, Moghis U Ahmad, Imran Ahmad
Endoxifen, an active metabolite of tamoxifen, has been shown to be an effective anti-estrogenic agent in estrogen receptor-positive breast cancer patients. In melanoma, estrogen receptor expression is shown to be associated with disease progression. However, the therapeutic benefit of endoxifen in melanoma has not yet been evaluated. Here, we present the first demonstration of the anti-melanogenic activity of endoxifen in vitro and in vivo. The in vitro cytotoxic effect of endoxifen was tested using a cell viability assay...
2018: Cellular & Molecular Biology Letters
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