journal
MENU ▼
Read by QxMD icon Read
search

Seminars in Cell & Developmental Biology

journal
https://www.readbyqxmd.com/read/28506897/aegerolysins-lipid-binding-proteins-with-versatile-functions
#1
REVIEW
Matej Butala, Maruša Novak, Nada Kraševec, Matej Skočaj, Peter Veranič, Peter Maček, Kristina Sepčić
Proteins of the aegerolysin family span many kingdoms of life. They are relatively widely distributed in bacteria and fungi, but also appear in plants, protozoa and insects. Despite being produced in abundance in cells at specific developmental stages and present in secretomes, only a few aegerolysins have been studied in detail. In particular, their organism-specific physiological roles are intriguing. Here, we review published findings to date on the distribution, molecular interactions and biological activities of this family of structurally and functionally versatile proteins, the aegerolysins...
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28506896/neurodevelopmental-macpfs-the-vertebrate-astrotactins-and-brinps
#2
REVIEW
Susan R Berkowicz, Aminah Giousoh, Phillip I Bird
Astrotactins (ASTNs) and Bone morphogenetic protein/retinoic acid inducible neural-specific proteins (BRINPs) are two groups of Membrane Attack Complex/Perforin (MACPF) superfamily proteins that show overlapping expression in the devel oping and mature vertebrate nervous system. ASTN(1-2) and BRINP(1-3) genes are found at conserved loci in humans that have been implicated in neurodevelopmental disorders (NDDs).
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28506895/the-node-and-beyond-using-social-media-in-cell-and-developmental-biology
#3
REVIEW
Catarina Vicente, Aidan Maartens, Katherine Brown
Traditionally, strong scientific communities have been at least partly built around physical proximity - either by members of the same department or institute, or through regular meetings and conferences. The online environment and the rise of social media platforms now make it easier to build virtual communities of geographically dispersed people with a common interest. In this article, we explore how such networks can be nurtured, focussing on the Node - a community blog for and by developmental biologists...
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28506894/the-functional-versatility-of-the-nuclear-pore-complex-proteins
#4
REVIEW
Mohammed Hezwani, Birthe Fahrenkrog
Over the past few decades, it is increasingly evident that nucleoporins are multi-functional proteins that are not only pivotal for the formation of the nuclear pore complex. They also have key roles in mitosis, gene expression, development and disease. In this review, the versatility and functions of nucleoporins outside the NPC will be discussed.
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28506893/macpf-cdc-proteins-in-development-insights-from-drosophila-torso-like
#5
REVIEW
Travis K Johnson, Michelle A Henstridge, Coral G Warr
The Membrane Attack Complex Perforin-like/Cholesterol-Dependent Cytolysin (MACPF) superfamily is an ancient and biologically diverse group of proteins that are best known for pore-forming roles in mammalian immunity and bacterial pathogenesis. Intriguingly, however, some eukaryotic proteins which contain the MACPF domain that defines this family do not act in attack or defence, and instead have distinct developmental functions. It remains unclear whether these proteins function via pore formation or have a different mechanism of action...
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28506892/the-roles-of-the-nuclear-pore-complex-in-cellular-dysfunction-aging-and-disease
#6
REVIEW
Stephen Sakuma, Maximiliano A D'Angelo
The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins), and the nucleocytoplasmic transport that it controls have revealed an unexpected layer to pathogenic disease onset and progression. Recent advances in the study of the regulation of NPC composition and function suggest that the precise control of this structure is necessary to prevent diseases from arising or progressing. Here we discuss the role of nucleoporins in a diverse set of diseases, many of which directly or indirectly increase in occurrence and severity as we age, and often shorten the human lifespan...
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28506891/viral-mechanisms-for-docking-and-delivering-at-nuclear-pore-complexes
#7
REVIEW
Justin W Flatt, Urs F Greber
Some viruses possess the remarkable ability to transport their genomes across nuclear pore complexes (NPCs) for replication inside the host cell's intact nuclear compartment. Viral mechanisms for crossing the restrictive NPC passageway are highly complex and astonishingly diverse, requiring in each case stepwise interaction between incoming virus particles and components of the nuclear transport machinery. Exactly how a large viral genome loaded with accessory proteins is able to pass through the relatively narrow central channel of the NPC without causing catastrophic structural damage is not yet fully understood...
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28506890/biomechanics-of-the-transport-barrier-in-the-nuclear-pore-complex
#8
REVIEW
George J Stanley, Ariberto Fassati, Bart W Hoogenboom
The nuclear pore complex (NPC) is the selective gateway through which all molecules must pass when entering or exiting the nucleus. It is a cog in the gene expression pathway, an entrance to the nucleus exploited by viruses, and a highly-tuned nanoscale filter. The NPC is a large proteinaceous assembly with a central lumen occluded by natively disordered proteins, known as FG-nucleoporins (or FG-nups). These FG-nups, along with a family of soluble proteins known as nuclear transport receptors (NTRs), form the selective transport barrier...
May 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28478299/clustered-protocadherin-trafficking
#9
REVIEW
Greg R Phillips, Nicole LaMassa, Yan Mei Nie
The cluster of almost 60 protocadherin genes, divided into the α, β and γ subgroups, is a hallmark of vertebrate nervous system evolution. These clustered protocadherins (Pcdhs) are of interest for several reasons, one being the arrangement of the genes, which allows epigenetic regulation at the cluster and single-cell identity. Another reason is the still ambiguous effect of Pcdhs on cell-cell interaction. Unlike the case for classical cadherins, which typically mediate strong cell adhesion and formation of adherens junctions, it has been challenging to ascertain exactly how Pcdhs affect interacting cells...
May 3, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28473267/functional-implication-of-the-common-evolutionary-origin-of-nuclear-pore-complex-and-endomembrane-management-systems
#10
REVIEW
Ivan Liashkovich, Victor Shahin
Nuclear pore complexes (NPCs) are the sole gateway between the cytoplasm and the nucleus serving both as stringent permeability barrier and active transporters between the two compartments of eukaryotic cells. Complete mechanistic understanding of how these two functions are implemented within one and the same transport machine has not been attained to date. Based on several lines of structural evidence, a hypothesis was proposed postulating that NPCs shares common evolutionary origin with other intracellular systems responsible for active management of endomembranes...
May 1, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28456604/herpesviruses-hijack-host-exosomes-for-viral-pathogenesis
#11
REVIEW
Sara Sadeghipour, Rommel A Mathias
Herpesviruses are remarkable pathogens possessing elaborate mechanisms to seize various host cellular components for immune evasion, replication, and virion egress. As viruses are dependent upon their hosts, investigating this intricate interplay has revealed that the exosome pathway is utilised by alpha (Herpes Simplex Virus 1), beta (Human Cytomegalovirus, and Human Herpesvirus 6) and gamma (Epstein-Barr Virus, and Kaposi Sarcoma-associated Herpesvirus) herpesviruses. Virions and exosomes share similar properties and functions...
April 26, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28454767/emergence-of-tissue-shape-changes-from-collective-cell-behaviours
#12
REVIEW
Frank Jülicher, Suzanne Eaton
Anyone watching a movie of embryonic development immediately appreciates the importance of morphogenetic movements and cell flows that reshape tissue. Dynamic tissue shape changes are genetically choreographed, but their execution is essentially a mechanical event. How the interplay between genetics and tissue mechanics controls tissue shape is a fundamental question. Key insights into this problem have emerged from studies in different model organisms as well as in cultured epithelia. These studies have revealed how gene expression patterns can generate patterns of planar cell polarity that orient cellular force generation and give rise to anisotropic mechanical properties of cells and tissues...
April 25, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28445785/staphylococcus-aureus-pore-forming-toxins-the-interface-of-pathogen-and-host-complexity
#13
REVIEW
E Sachiko Seilie, Juliane Bubeck Wardenburg
Staphylococcus aureus is a prominent human pathogen capable of infecting a variety of host species and tissue sites. This versatility stems from the pathogen's ability to secrete diverse host-damaging virulence factors. Among these factors, the S. aureus pore-forming toxins (PFTs), α-toxin and the bicomponent leukocidins, have garnered much attention for their ability to lyse cells at low concentrations and modulate disease severity. Although many of these toxins were discovered nearly a century ago, their host cell specificity has only been elucidated over the past five to six years, starting with the discovery of the eukaryotic receptor for α-toxin and rapidly followed by identification of the leukocidin receptors...
April 23, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28412537/delivering-effective-science-communication-advice-from-a-professional-science-communicator
#14
REVIEW
Sam Illingworth
Science communication is becoming ever more prevalent, with more and more scientists expected to not only communicate their research to a wider public, but to do so in an innovative and engaging manner. Given the other commitments that researchers and academics are required to fulfil as part of their workload models, it is unfair to be expect them to also instantly produce effective science communication events and activities. However, by thinking carefully about what it is that needs to be communicated, and why this is being done, it is possible to develop high-quality activities that are of benefit to both the audience and the communicator(s)...
April 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28396106/the-bcl-2-family-of-proteins-and-mitochondrial-outer-membrane-permeabilisation
#15
REVIEW
Richard W Birkinshaw, Peter E Czabotar
Apoptosis is a form of programmed cell death critical for the development and homeostasis of multicellular organisms. A key event within the mitochondrial pathway to apoptosis is the permeabilisation of the mitochondrial outer membrane (MOM), a point of no return in apoptotic progression. This event is governed by a complex interplay of interactions between BCL-2 family members. Here we discuss the roles of opposing factions within the family. We focus on the structural details of these interactions, how they promote or prevent apoptosis and recent developments towards understanding the conformational changes of BAK and BAX that lead to MOM permeabilisation...
April 7, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28366828/pathogen-derived-extracellular-vesicles-coordinate-social-behaviour-and-host-manipulation
#16
REVIEW
Yifat Ofir-Birin, Meta Heidenreich, Neta Regev-Rudzki
Infectious diseases are the leading cause of death of children worldwide, causing a tenacious and major public-health burden. The dynamic interplay between pathogens and their host is one of the most complicated themes of the disease progression. Pathogens excel in developing different means to facilitate cell-cell communication via secreted vesicles, among others. The released vesicles are involved in the transfer of biologically active molecules that induce phenotypic changes in the recipient cells. The messages within the vesicles are delivered to coordinate diverse processes, including virulence factor expression, differentiation state and control of their population density...
March 30, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28341363/a-gene-regulatory-program-controlling-early-xenopus-mesendoderm-formation-network-conservation-and-motifs
#17
REVIEW
Rebekah M Charney, Kitt D Paraiso, Ira L Blitz, Ken W Y Cho
Germ layer formation is among the earliest differentiation events in metazoan embryos. In triploblasts, three germ layers are formed, among which the endoderm gives rise to the epithelial lining of the gut tube and associated organs including the liver, pancreas and lungs. In frogs (Xenopus), where early germ layer formation has been studied extensively, the process of endoderm specification involves the interplay of dozens of transcription factors. Here, we review the interactions between these factors, summarized in a transcriptional gene regulatory network (GRN)...
March 22, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28267596/extracellular-vesicles-in-lung-cancer-from-bench-to-bedside
#18
REVIEW
Tsukasa Kadota, Yusuke Yoshioka, Yu Fujita, Kazuyoshi Kuwano, Takahiro Ochiya
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite significant advances in lung cancer research and novel therapies, a better understanding of the disease is crucially needed to facilitate early detection and appropriate diagnoses and to improve treatment outcomes. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from all tested cell types and modulate cell-cell communication. EVs transfer a wide variety of molecules, such as proteins, messenger RNAs and microRNAs...
March 4, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28483138/editorial
#19
EDITORIAL
Jennifer Susan Stone, Nicolas Daudet
No abstract text is available yet for this article.
May 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27989562/changing-shape-and-shaping-change-inducing-the-inner-ear
#20
REVIEW
Raj K Ladher
The inner ear arises from non-neural ectoderm as a result of instructions sent by surrounding tissues. These interactions progressively restrict the potential of the ectoderm, resulting in the formation of the otic placode, a disk of thickened ectoderm that will give rise to all of the inner ear derivatives and its neurons. While otic placode is a surface structure, the inner ear is internalised, embedded within the cranial mesenchyme. Here, the cellular and molecular interactions that restrict the lineage of non-neural ectoderm in its transition to otic placode are reviewed, and how these interactions impinge on the coordination of otic placodal cell shape that drive the dramatic morphogenesis of the placode, as it becomes the otocyst...
May 2017: Seminars in Cell & Developmental Biology
journal
journal
32522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"