journal
MENU ▼
Read by QxMD icon Read
search

Seminars in Cell & Developmental Biology

journal
https://www.readbyqxmd.com/read/30172762/modulating-transcription-factor-activity-interfering-with-protein-protein-interaction-networks
#1
REVIEW
Mathias Francois, Prue Donovan, Frank Fontaine
Biophysical parameters that govern transcription factors activity are binding locations across the genome, dwelling time at these regulatory elements and specific protein-protein interactions. Most molecular strategies used to develop small compounds that block transcription factors activity have been based on biochemistry and cell biology methods that that do not take into consideration these key biophysical features. Here, we review the advance in the field of transcription factor biology and describe how their interactome and transcriptional regulation on a genome wide scale have been deciphered...
September 12, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30213760/the-role-of-ubiquitination-in-the-regulation-of-primary-cilia-assembly-and-disassembly
#2
REVIEW
Delowar Hossain, William Y Tsang
The primary cilium is a cellular antenna found on the surface of many eukaryotic cells, whose main role is to sense and transduce signals that regulate growth, development, and differentiation. Although once believed to be a vestigial organelle without important function, it has become clear that defects in primary cilium are responsible for a wide variety of genetic diseases affecting many organs and tissues, including the brain, eyes, heart, kidneys, liver, and pancreas. The primary cilium is mainly present in quiescent and differentiated cells, and controls must exist to ensure that this organelle is assembled or disassembled at the right time...
September 10, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30195063/roles-of-ubiquitin-in-autophagy-and-cell-death
#3
REVIEW
Carlos Gómez-Díaz, Fumiyo Ikeda
The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell survival: essential nutrients are generated by autophagy-dependent degradation and recycling of cellular garbage. On the other hand, cell death is induced by different programs, such as apoptosis, pyroptosis, and necroptosis. Emerging evidence is revealing how cell survival and cell death pathways are coordinated to determine cell fate. For instance, posttranslational modification of proteins with ubiquitin regulates many steps of autophagy and cell death pathways...
September 10, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30193996/the-contributions-of-mesoderm-derived-cells-in-liver-development
#4
REVIEW
Li Yang, Lin-Chen Li, Lamaoqiezhong, Xin Wang, Wei-Hua Wang, Yan-Chun Wang, Cheng-Ran Xu
The liver is an indispensable organ for metabolism and drug detoxification. The liver consists of endoderm-derived hepatobiliary lineages and various mesoderm-derived cells, and interacts with the surrounding tissues and organs through the ventral mesentery. Liver development, from hepatic specification to liver maturation, requires close interactions with mesoderm-derived cells, such as mesothelial cells, hepatic stellate cells, mesenchymal cells, liver sinusoidal endothelial cells and hematopoietic cells...
September 10, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30193995/the-mesentery-as-the-epicenter-for-intestinal-regeneration
#5
REVIEW
José E García-Arrarás, Samir A Bello, Sonya Malavez
The mesentery, a newly minted organ, plays various anatomical and physiological roles during animal development. In echinoderms, and particularly in members of the class Holothuroidea (sea cucumbers) the mesentery plays an additional unique role: it is crucial for the process of intestinal regeneration. In these organisms, a complete intestine can form from cells that originate in the mesentery. In this review, we focus on what is known about the changes that take place in the mesentery and what has been documented on the cellular and molecular mechanisms involved...
September 5, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30172047/epigenetic-regulation-of-renal-development
#6
REVIEW
Samir S El-Dahr, Zubaida Saifudeen
Developmental changes in cell fate are tightly regulated by cell-type specific transcription factors. Chromatin reorganization during organismal development ensures dynamic access of developmental regulators to their cognate DNA sequences. Thus, understanding the epigenomic states of promoters and enhancers is of key importance. Recent years have witnessed significant advances in our knowledge of the transcriptional mechanisms of kidney development. Emerging evidence suggests that histone deacetylation by class I HDACs and H3 methylation on lysines 4, 27 and 79 play important roles in regulation of early and late gene expression in the developing kidney...
September 5, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30193994/epithelial-to-mesenchymal-transition-based-morphogenesis-of-dorsal-mesentery-and-gonad
#7
REVIEW
Takashi Yoshino, Daisuke Saito
Dorsal mesentery and gonad (ovary and testis) are formed in distinct regions of the body and have different characteristics. Recent studies using chicken embryos showed that progenitors of these two organs are derived from the coelomic lining region, a ventral part of the medial lateral plate mesoderm (M-LPM). Furthermore, both types of progenitors develop in a similar manner, concomitant with morphological changes termed the epithelial-to-mesenchymal transition (EMT). EMT processes in both dorsal mesentery and gonad formation are regulated by BMP signaling...
September 4, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30172049/pancreas-organogenesis-approaches-to-elucidate-the-role-of-epithelial-mesenchymal-interactions
#8
REVIEW
Lina Sakhneny, Laura Khalifa-Malka, Limor Landsman
Pancreas organogenesis depends on proper interactions of endoderm-derived epithelial cells, which will form the exocrine and endocrine cells of the adult organ, with their surrounding mesenchymal layer. Research on the role of pancreatic mesenchyme, pioneered by Golosow and Grobstein in the 1960's, revealed these cells regulate multiple events during pancreas development. Still, much is unknown regards the molecular basis of epithelial-mesenchymal interactions in this process. Here, we review in vivo and ex vivo approaches to study mesenchymal requirements for mammal pancreas organogenesis, and how gained knowledge is being translated toward the development of cell replacement therapy for diabetes...
September 4, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30172048/impact-of-next-generation-sequencing-on-our-understanding-of-cakut
#9
REVIEW
Anukrati Nigam, Nine V A M Knoers, Kirsten Y Renkema
Congenital abnormalities of the kidney and urinary tract (CAKUT) form the leading cause of pediatric end-stage renal disease. Knowledge on the molecular mechanisms that underlie CAKUT leads to the improvement of DNA diagnostics and counseling regarding prognosis and recurrence risk estimation for CAKUT patients and their relatives. Implementation of next generation sequencing in research and diagnostic settings has led to the identification of the molecular basis of many developmental diseases. In this review, we summarize the efforts on next generation sequencing in CAKUT research and we discuss how next generation sequencing added to our understanding of CAKUT genetics...
September 4, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30165150/extracellular-matrix-scaffolding-in-angiogenesis-and-capillary-homeostasis
#10
REVIEW
Marion Marchand, Catherine Monnot, Laurent Muller, Stéphane Germain
The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular basement membrane (BM) and the interstitial ECM is identified as a crucial component of the vasculature. We here focus on the unique molecular composition and scaffolding of the capillary ECM, which provides structural support to blood vessels and regulates properties of endothelial cells and pericytes. The major components of the BM are collagen IV, laminins, heparan sulfate proteoglycans and nidogen and also associated proteins such as collagen XVIII and fibronectin...
September 4, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30009945/cancer-invasion-into-musculature-mechanics-molecules-and-implications
#11
REVIEW
Lianne Beunk, Kari Brown, Iris Nagtegaal, Peter Friedl, Katarina Wolf
Tumor invasion along structural interphases of surrounding tumor-free tissue represents a key process during tumor progression. Much attention has been devoted to mechanisms of tumor cell migration within extracellular matrix (ECM)-rich connective tissue, however a comprehensive understanding of tumor invasion into tissue of higher structural complexity, such as muscle tissue, is lacking. Muscle invasion in cancer patients is often associated with destructive growth and worsened prognosis. Here, we review biochemical, geometrical and mechanical cues of smooth and skeletal muscle tissues and their relevance for guided invasion of cancer cells...
September 4, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30184476/recapitulating-kidney-development-progress-and-challenges
#12
REVIEW
Melissa H Little, Santhosh V Kumar, Thomas Forbes
Decades of research into the molecular and cellular regulation of kidney morphogenesis in rodent models, particularly the mouse, has provided both an atlas of the mammalian kidney and a roadmap for recreating kidney cell types with potential applications for the treatment of kidney disease. With advances in both our capacity to maintain nephron progenitors in culture, reprogram to kidney cell types and direct the differentiation of human pluripotent stem cells to kidney endpoints, renal regeneration via cellular therapy or tissue engineering may be possible...
September 2, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30172050/turning-mesoderm-into-kidney
#13
REVIEW
Alan J Davidson, Paula Lewis, Aneta Przepiorski, Veronika Sander
The intermediate mesoderm is located between the somites and the lateral plate mesoderm and gives rise to renal progenitors that contribute to the three mammalian kidney types (pronephros, mesonephros and metanephros). In this review, focusing largely on murine kidney development, we examine how the intermediate mesoderm forms during gastrulation/axis elongation and how it progressively gives rise to distinct renal progenitors along the rostro-caudal axis. We highlight some of the potential signalling cues and core transcription factor circuits that direct these processes, up to the point of early metanephric kidney formation...
September 1, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30153479/-a-narrow-bridge-home-the-dorsal-mesentery-in-primordial-germ-cell-migration
#14
REVIEW
Gideon Hen, Dalit Sela-Donenfeld
Specification of primordial germ cells (PGCs) in all vertebrates takes place in extragonadal sites. This requires migration of PGCs through embryonic tissues towards the genital ridges by both passive and active types of migration. Commonly, colonization in the genital ridges follows migration of the PGCs along the thin tissue of the dorsal mesentery. Here we review the anatomy of the dorsal mesentery, the role it plays in migration of PGCs, and the interactions of PGCs with different cell types, extracellular matrix and signaling pathways that are all essential for attraction and orientation of PGCs along the dorsal mesentery towards the gonad anlage...
August 29, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30142441/the-development-of-the-dorsal-mesentery-in-human-embryos-and-fetuses
#15
REVIEW
Jill P J M Hikspoors, Nutmethee Kruepunga, Greet M C Mommen, Jean-Marie P W U Peeters, Cindy J M Hülsman, S Eleonore Köhler, Wouter H Lamers
The vertebrate intestine has a continuous dorsal mesentery between pharynx and anus that facilitates intestinal mobility. Based on width and fate the dorsal mesentery can be subdivided into that of the caudal foregut, midgut, and hindgut. The dorsal mesentery of stomach and duodenum is wide and topographically complex due to strong and asymmetric growth of the stomach. The associated formation of the lesser sac partitions the dorsal mesentery into the right-sided "caval fold" that serves as conduit for the inferior caval vein and the left-sided mesogastrium...
August 25, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30142440/mesodermal-induction-of-pancreatic-fate-commitment
#16
REVIEW
Philip A Seymour, Palle Serup
The pancreas is a compound gland comprised of both exocrine acinar and duct cells as well as endocrine islet cells. Most notable amongst the latter are the insulin-synthesizing β-cells, loss or dysfunction of which manifests in diabetes mellitus. All exocrine and endocrine cells derive from multipotent pancreatic progenitor cells arising from the primitive gut epithelium via inductive interactions with adjacent mesodermal tissues. Research in the last two decades has revealed the identity of many of these extrinsic cues and they include signaling molecules used in many other developmental contexts such as retinoic acid, fibroblast growth factors, and members of the TGF-β superfamily...
August 25, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30004018/the-advances-in-crispr-technology-and-3d-genome
#17
REVIEW
William Wang, Linlin Zhang, Xiangdong Wang, Yiming Zeng
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) system is a prokaryotic immune system that used to resist foreign genetic factors. It rapidly becomes the hot technology in life sciences and is applies for genome editing to solve the problem of genome-derived diseases. Using CRISPR/Cas technique, the biological DNA sequence can be repaired, cut, replaced, or added. It can effectively change the human stem cells and is expected to achieve results in the treatment...
August 25, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30125668/simulation-of-different-three-dimensional-polymer-models-of-interphase-chromosomes-compared-to-experiments-an-evaluation-and-review-framework-of-the-3d-genome-organization
#18
REVIEW
Tobias A Knoch
Despite all the efforts the three-dimensional higher-order architecture and dynamics in the cell nucleus are still debated. The regulation of genes, their transcription, replication, as well as differentiation in Eukarya is, however, closely connected to this architecture and dynamics. Here, an evaluation and review framework is setup to investigate the folding of a 30 nm chromatin fibre into chromosome territories by comparing computer simulations of two different chromatin topologies to experiments: The Multi-Loop-Subcompartment (MLS) model, in which small loops form rosettes connected by chromatin linkers, and the Random-Walk/Giant-Loop (RW/GL) model, in which large loops are attached to a flexible non-protein backbone, were simulated for various loop, rosette, and linker sizes...
August 24, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30096364/roles-of-nipbl-in-maintenance-of-genome-stability
#19
REVIEW
Danyan Gao, Bijun Zhu, Xin Cao, Miaomiao Zhang, Xiangdong Wang
A cohesin-loading factor (NIPBL) is one of important regulatory factors in the maintenance of 3D genome organization and function, by interacting with a large number of factors, e.g. cohesion, CCCTC-binding factor (CTCF) or cohesin complex component. The present article overviews the critical and regulatory roles of NIBPL in cohesion loading on chromotin and in gene expression and transcriptional signaling. We explore molecular mechanisms by which NIPBL recruits endogenous histone deacetylase (HDAC) to induce histone deacetylation and influence multi-dimensions of genome, through which NIPBL "hop" movement in chromatin regulates gene expression and alters genome folding...
August 17, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/30096363/roles-of-cohesin-in-chromosome-architecture-and-gene-expression
#20
REVIEW
Zhenhua Zhu, Xiangdong Wang
Cohesin-mediated chromatin organization plays an important role in formation and stabilization of chromosome architecture and gene regulation. Mechanisms by which cohesin shapes chromosome and regulates gene expression remain unclear. The present article overviews biological characters and functions of cohesin and core subunits and explores roles of regulatory factors (e.g. Pds5, Wapl, and Eco1) in dynamic behaviors of cohesin. Cohesin interacts with CCCTC binding factor (CTCF) and other factors to maintain and stabilize multi-dimensional organizations of topological loops and distances between sites during cell segmentation...
August 17, 2018: Seminars in Cell & Developmental Biology
journal
journal
32522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"