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Audiology & Neuro-otology

David R Friedmann, Leena Asfour, William H Shapiro, J Thomas Roland, Susan B Waltzman
OBJECTIVE: To assess bimodal auditory performance in children with a cochlear implant (CI) and contralateral auditory brainstem implant (ABI). METHODS: This is a retrospective case review performed at a tertiary referral center. Four patients with cochlear nerve deficiency initially underwent cochlear implantation but were not benefiting from their devices and underwent ABI in the contralateral ear. The main outcome measures included age-appropriate speech perception and production assessments...
November 2, 2018: Audiology & Neuro-otology
Ilyoung Cho, Hyun-Min Lee, Sung-Won Choi, Soo-Keun Kong, Il-Woo Lee, Eui-Kyung Goh, Se-Joon Oh
OBJECTIVES: This study aimed to investigate the efficacy of simultaneous steroid and hyperbaric oxygen therapy (HBOT) in patients with severe to profound idiopathic sudden sensorineural hearing loss (ISSNHL), which has a poor prognosis. METHODS: Sixty patients diagnosed with severe to profound ISSNHL (≥70 dB HL) were randomly divided into two groups in a prospective controlled trial: an oral steroid + intratympanic steroid injection (ITSI) group (control group) and an oral steroid + ITSI + HBOT group (study group)...
October 31, 2018: Audiology & Neuro-otology
Mohammad-Reza Mahmoudian-Sani, Mohammad-Saeid Jami, Ali Mahdavinezhad, Razieh Amini, Gholamreza Farnoosh, Massoud Saidijam
Hearing loss is considered the most common sensory disorder across the world. Nowadays, a cochlear implant can be an effective treatment for patients. Moreover, it is often believed that sensorineural hearing loss in humans is caused by loss or disruption of the function of hair cells in the cochlea. In this respect, mesenchymal cells can be a good candidate for cell-based therapeutic approaches. To this end, the potential of human bone marrow-derived mesenchymal stem cells to differentiate into hair cells with the help of transfection of microRNA in vitro was investigated...
October 31, 2018: Audiology & Neuro-otology
Camille Dorbeau, John Galvin, Qian-Jie Fu, Elsa Legris, Mathieu Marx, David Bakhos
Cochlear implantation (CI) can benefit patients with single-sided deafness (SSD) in terms of sound localization, speech understanding in noise, tinnitus severity, and quality of life (QoL). In previous studies, CI outcomes have been largely reported for SSD patients with normal "unrestricted" hearing in the contralateral ear. However, SSD patients may often have some degree of hearing loss in the contralateral ear ("restricted" acoustic hearing). In this study, we report results from a French clinical trial for CI in in SSD patients (NCT02204618)...
October 23, 2018: Audiology & Neuro-otology
William Crohan, Jay Krishnaswamy, Gunesh Rajan
AIM: To investigate and compare residual hearing preservation between patients based on the presence of intraoperative gusher. METHODOLOGY: We retrospectively compared 2 cohorts of cochlear implant recipients significantly distinguished by whether or not they experienced gusher intraoperatively. Patients underwent cochlear implantation using 24-mm lateral wall electrode arrays as well pharmacologic steroid protection. All patients were assessed by a hearing implant MDT...
October 10, 2018: Audiology & Neuro-otology
Junming Chen, Xiaowei Zhou, Tuanming Zou, Bochen Wang, Youjun Yu, Feng Lin, Kangsong Chen, Yanbing Lai, Kai Sun
Survival of cochlear sensory epithelial cells may be regulated by inhibitor of differentiation-1 (Id1) and the N-methyl-D-aspartic acid (NMDA) receptor. However, it is unclear whether Id1 and the NMDA receptor are involved in the radiation-mediated survival of rat cochlear sensory epithelial cells. Here, we show that the percentage of apoptotic cells increased, the percentage of cells in the S phase decreased, Id1 mRNA and protein expression decreased and the NMDA receptor subtype 2B (NR2B) mRNA and protein level increased in OC1 cells after radiation...
October 9, 2018: Audiology & Neuro-otology
Katarzyna Pawlak-Osińska, Katarzyna Linkowska, Karolina Hołub, Katarzyna Winiarska, Bartosz Stankiewicz, Henryk Kaźmierczak, Stanisław Osiński, Maria Marzec, Tomasz Grzybowski
Considering the possibility of a common genetic background of vertigo and epilepsy, we genotyped an affected group of individuals with vertigo and an unaffected group, by studying 26 single-nucleotide polymorphisms (SNPs) in 14 genes which were previously reported to be of particular importance for epilepsy. Significant differences were found between the patients and the control group (χ2 = 38.3, df = 3, p = 1.6 × 10-7) for the frequencies of haplotypes consist ing of 2 SNPs located in chromosome 11 (rs1939012 and rs1783901 within genes MMP8 and SCN3B, respectively)...
October 9, 2018: Audiology & Neuro-otology
Seiji Hosokawa, Kumiko Hosokawa, Goro Takahashi, Ken-Ichi Sugiyama, Hiroshi Nakanishi, Satoru Takebayashi, Hiroyuki Mineta
We analyzed 356 patients with idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and systemic steroids (n = 161), systemic steroids alone (n = 160), or intratympanic and systemic steroids (n = 35). The main outcome measure was the hearing recovery rate. The effect of other variables, including the initial averaged 5-frequency hearing level, patient age, interval between the onset of symptoms and treatment, presence of vertigo as a complication, presence of diabetes mellitus, smoking history, and presence of hypertension, on the hearing recovery rate was also evaluated...
October 9, 2018: Audiology & Neuro-otology
Chun Liang, Lisa M Houston, Ravi N Samy, Lamiaa Mohamed Ibrahim Abedelrehim, Fawen Zhang
The purpose of this study was to examine neural substrates of frequency change detection in cochlear implant (CI) recipients using the acoustic change complex (ACC), a type of cortical auditory evoked potential elicited by acoustic changes in an ongoing stimulus. A psychoacoustic test and electroencephalographic recording were administered in 12 postlingually deafened adult CI users. The stimuli were pure tones containing different magnitudes of upward frequency changes. Results showed that the frequency change detection threshold (FCDT) was 3...
October 9, 2018: Audiology & Neuro-otology
Christof Stieger, Xenia Siemens, Flurin Honegger, Kourosh Roushan, Daniel Bodmer, John Allum
BACKGROUND: After cochlear implant (CI) surgery, some patients experience vertigo, dizziness and/or deficits in vestibulo-ocular reflexes. However, little is known about the effect of CI surgery on balance control. Therefore, we examined differences in stance and gait balance control before versus after CI surgery. METHODS: Balance control of 30 CI patients (mean age 59, SD 15.4 years), receiving a first unilateral CI surgery, was measured preoperatively and postoperatively 1 month after the initial implant stimulation (2 months after surgery)...
October 9, 2018: Audiology & Neuro-otology
John Ka Keung Sung, Betty Pui Ki Luk, Terence Ka Cheong Wong, Jiun Fong Thong, Hoi Tung Wong, Michael Chi Fai Tong
OBJECTIVE: This is a retrospective review of the impact of an Auditory Brainstem Implant (ABI) on the audiological rehabilitation and tonal language development of pediatric patients with prelingual profound deafness in Hong Kong. RESULTS: From January 2009 to February 2015, 11 pediatric patients with profound prelingual deafness received an ABI in Hong Kong (age range 1.67-3.75 years). Etiologies included Cochlear Nerve Deficiency in 7, Severe Cochlear Malformations in 2, and Retrocochlear Deafness in 2...
2018: Audiology & Neuro-otology
Elif Tugba Sarac, Bilgehan Boke, Semsettin Okuyucu
INTRODUCTION: Sickle cell anemia is a disease characterized by a wide vaso-occlusive incident from micro-vascular incident to muscularactivity. The cochlear function can also get affected by this vaso-occlusion. OBJECTIVE: It is aimed at determining what kind of effects sickle cell anemia has on hearing and balance system. METHODS: This study has been conducted on 46 patients with sickle cell anemia and 45 healthy individuals. For all participants, their pure tone hearing thresholds and videonystagmography (VNG) findings have been determined in 17 frequencies between 125-16...
2018: Audiology & Neuro-otology
Yu-Hao Liao, Yi-Ho Young
Firecrackers are still popular among the general public of various populations worldwide. This study investigated inner ear damage in patients with firecracker trauma and analyzed noise levels in 6 kinds of commercially available firecrackers. During the past 20 years, we have experienced 30 patients with firecracker trauma. An inner ear test battery comprising audiometry, cervical and ocular vestibular-evoked myogenic potential (cVEMP and oVEMP) tests and a caloric test was performed. The real-time noise levels were measured outdoors at a distance of 2, 4 and 6 m away from a lighting firecracker to mimic a noise event...
2018: Audiology & Neuro-otology
Hannes Maier, Uwe Baumann, Wolf-Dieter Baumgartner, Dirk Beutner, Marco D Caversaccio, Thomas Keintzel, Martin Kompis, Thomas Lenarz, Astrid Magele, Torsten Mewes, Alexander Müller, Tobias Rader, Torsten Rahne, Sebastian P Schraven, Burkard Schwab, Georg Mathias Sprinzl, Bernd Strauchmann, Ingo Todt, Thomas Wesarg, Barbara Wollenberg, Stefan K Plontke
There is currently no standardized method for reporting audiological, surgical and subjective outcome measures in clinical trials with active middle ear implants (AMEIs). It is often difficult to compare studies due to data incompatibility and to perform meta-analyses across different centres is almost impossible. A committee of ENT and audiological experts from Germany, Austria and Switzerland decided to address this issue by developing new minimal standards for reporting the outcomes of AMEI clinical trials...
2018: Audiology & Neuro-otology
Katharina Wilms, Arneborg Ernst, Philipp Mittmann
BACKGROUND: Patients with a superior canal dehiscence syndrome display symptoms of the vestibular disorder except that of hearing loss. Therefore, any type of surgery should treat those symptoms without affecting the hearing threshold. The aim of this study was to evaluate the extent to which the hearing threshold has been affected; the evaluation process was carried out by a transmastoid plugging of the superior canal. Another aim was to estimate the risk in loss of hearing due to this surgery...
2018: Audiology & Neuro-otology
Nicolas Verhaert, Charlotte Borgers, Katleen De Voecht, Ellen Boon, Christian Desloovere
Recent findings support the efficacy of the direct acoustic cochlear implant (DACI) in patients with advanced otosclerosis whose rehabilitation is very challenging. Standard treatment consists of stapes surgery combined with hearing aids or a cochlear implant (CI). CI surgery, however, is often challenging depending on the grade of otosclerosis. This study aims to compare speech perception scores in quiet and noise of 6 DACI and 12 CI patients with advanced otosclerosis at 3 and 12 months after fitting. Preoperative computed tomographic scans of all patients were scored by experts using an existing otosclerosis grading system (stages 1-3)...
2018: Audiology & Neuro-otology
Caroline Salmon, Sébastien Barriat, Philippe P Lefebvre
OBJECTIVES: To evaluate the efficacy of stapes surgery in patients presenting with a preoperative mixed hearing loss (bone conduction thresholds ≥40 dB; 40 < air conduction thresholds (AC) < 85 dB). PATIENTS AND METHODS: A total of 30 patients (32 ears) with mixed hearing loss who underwent primary stapedotomy were evaluated. Audiometric parameters were assessed before and after surgery. Contralateral thresholds were also reported. The need for a hearing aid (HA) after surgery and its impact on quality of life were also measured...
2018: Audiology & Neuro-otology
Chengjing Zhu, Julia Clara Gausterer, Hanna Schöpper, Michael Nieratschker, Nodir Saidov, Navid Ahmadi, Clemens Honeder, Franz Gabor, Christoph Arnoldner
The otoprotective effects of thermoreversible poloxamer 407 hydrogels containing dexamethasone or triamcinolone acetonide were evaluated in an animal model of noise-induced hearing loss. Seven days after noise exposure, hearing threshold shifts at 16 kHz were significantly reduced in the 6% dexamethasone group (p < 0.05). Even though no significant differences in hair cell counts were found, histological analysis revealed a significantly higher spiral ganglion cell density in the first turn of the cochlea in this group (p < 0...
2018: Audiology & Neuro-otology
Sherifa A Hamed, Amira M Oseilly
BACKGROUND: Epilepsy is a chronic medical disease and is associated with comorbid adverse somatic conditions due to epilepsy itself or its long-term treatment. OBJECTIVES: This study evaluated cochlear function in patients with idiopathic epilepsy and treated with carbamazepine (CBZ). PATIENTS AND METHODS: Included were 47 patients (mean age = 34.56 ± 7.11 years and duration of illness = 17.84 ± 7.21 years) and 40 healthy subjects. They underwent pure-tone audiometry and transient evoked otoacoustic emission (TEOAE) analyses...
2018: Audiology & Neuro-otology
Kumiko Hosokawa, Seiji Hosokawa, Satoru Takebayashi, Hiroyuki Mineta
Acoustic neuroma sometimes presents with sudden-onset sensorineural hearing loss as a primary symptom. We investigated 848 untreated cases that included 20 cases with acoustic neuroma with sudden-onset sensorineural hearing loss and 828 cases without acoustic neuroma. Fourteen of the 20 acoustic neuroma and 90 of the 828 cases of sudden-onset sensorineural hearing loss showed a trough-shaped audiogram with the greatest amount of hearing loss in the mid-frequency range. The incidence of a trough-shaped audiogram was significantly higher in patients with acoustic neuroma than in those without (p < 0...
2018: Audiology & Neuro-otology
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