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Audiology & Neuro-otology

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https://www.readbyqxmd.com/read/28889125/brimonidine-protects-auditory-hair-cells-from-in-vitro-induced-toxicity-of-gentamicin
#1
Maurizio Cortada, Soledad Levano, Daniel Bodmer
Brimonidine, an alpha-2 adrenergic receptor (α2-AR) agonist, has neuroprotective effects in the visual system and in spiral ganglion neurons. Auditory hair cells (HCs) express all 3 α2-AR subtypes, but their roles in HCs remain unknown. This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined...
September 9, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28848089/histopathology-of-the-human-inner-ear-in-the-cogan-syndrome-with-cochlear-implantation
#2
Takefumi Kamakura, Daniel J Lee, Barbara S Herrmann, Joseph B Nadol
The Cogan syndrome is a rare disorder characterized by nonsyphilitic interstitial keratitis and audiovestibular symptoms. Profound sensorineural hearing loss has been reported in approximately half of the patients with the Cogan syndrome resulting in candidacy for cochlear implantation in some patients. The current study is the first histopathologic report on the temporal bones of a patient with the Cogan syndrome who during life underwent bilateral cochlear implantation. Preoperative MRI revealed tissue with high density in the basal turns of both cochleae and both vestibular systems consistent with fibrous tissue due to labyrinthitis...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28848077/perception-of-iterated-rippled-noise-periodicity-in-cochlear-implant-users
#3
Luise Wagner, Stefan K Plontke, Torsten Rahne
Pitch perception is more challenging for individuals with cochlear implants (CIs) than normal-hearing subjects because the signal processing by CIs is restricted. Processing and perceiving the periodicity of signals may contribute to pitch perception. Whether individuals with CIs can discern pitch within an iterated rippled noise (IRN) signal is still unclear. In a prospective controlled psychoacoustic study with 34 CI users and 15 normal-hearing control subjects, the difference limen between IRN signals with different numbers of iterations was measured...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28817812/the-mir-34a-bcl-2-pathway-contributes-to-auditory-cortex-neuron-apoptosis-in-age-related-hearing-loss
#4
Qiuhong Huang, Yongkang Ou, Hao Xiong, Haidi Yang, Zhigang Zhang, Suijun Chen, Yongyi Ye, Yiqing Zheng
HYPOTHESIS: The miR-34a/Bcl-2 signaling pathway may play a role in the mechanisms related to age-related hearing loss (AHL) in the auditory cortex. BACKGROUND: The auditory cortex plays a key role in the recognition and processing of complex sound. It is difficult to explain why patients with AHL have poor speech recognition, so increasing numbers of studies have focused on its central change. Although micro (mi)RNAs in the central nervous system have recently been increasingly reported to be associated with age-related diseases, the molecular mechanisms of AHL in the auditory cortex are not fully understood...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28793285/resistance-of-gerbil-auditory-function-to-reversible-decrease-in-cochlear-blood-flow
#5
Fahd El Afia, Fabrice Giraudet, Laurent Gilain, Thierry Mom, Paul Avan
The objective was to design in gerbils a model of reversible decrease in cochlear blood flow (CBF) and analyze its influence on cochlear function. In Mongolian gerbils injected with ferromagnetic microbeads, a magnet placed near the porus acusticus allowed CBF to be manipulated. The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. In 13 of the 20 successfully injected gerbils, stable CBF reduction was obtained for 11.5 min on average. The CM was affected only when CBF fell to less than 60% of its baseline, yet remained >40% of its initial level in about 2/3 of such cases...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28738350/unilateral-sensorineural-hearing-loss-medical-context-and-etiology
#6
Antoine Paul, Sandrine Marlin, Marine Parodi, Isabelle Rouillon, Joanne Guerlain, Véronique Pingault, Vincent Couloigner, Erea Noel Garabedian, Françoise Denoyelle, Natalie Loundon
OBJECTIVE: Unilateral sensorineural hearing loss (USNHL) is known to impact on school performance and social skills during childhood, but the etiologies remain unclear. The aim of this study was to assess various etiologies and to study the clinical contexts in this population. METHODS: The study is a retrospective review. Characteristics of hearing loss (HL), audiometric parameters, imaging, and genetic and medical contexts were analyzed. RESULTS: Eighty children were included...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28723686/population-based-study-on-the-epidemiology-of-m%C3%A3-ni%C3%A3-re-s-disease
#7
Saskia G Bruderer, Daniel Bodmer, Nadja A Stohler, Susan S Jick, Christoph R Meier
BACKGROUND AND OBJECTIVE: Ménière's disease (MD) is a disorder of the inner ear typically showing recurrent acute episodes of vertigo, hearing loss, and tinnitus. Epidemiologic studies on MD are scarce. We assessed the incidence rates (IRs) of MD and describe the characteristics of MD cases, comparing them to control patients without recorded evidence of MD. STUDY DESIGN: We conducted a retrospective population-based follow-up study and a nested case-control analysis using data from the UK-based Clinical Practice Research Datalink...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28719901/patient-related-benefits-for-adults-with-cochlear-implantation-a-multicultural-longitudinal-observational-study
#8
Thomas Lenarz, Lida Muller, Hanna Czerniejewska-Wolska, Hector Vallés Varela, César Orús Dotú, Marcin Durko, Alicia Huarte Irujo, Bartosz Piszczatowski, Marek Zadrożniak, Colin Irwin, Petra L Graham, Josie Wyss
OBJECTIVES: To assess subjectively perceived, real-world benefits longitudinally for unilateral cochlear implant (CI) recipients in a multinational population treated routinely. To identify possible predictors of self-reported benefits. DESIGN: This was a prospective, multicenter, repeated-measures study. Self-assessment of performance at preimplantation and postimplantation at 1, 2, and 3 years using standardized, validated, local language versions of the Speech, Spatial, and Qualities of Hearing Scale (SSQ), and the Health Utilities Index Mark 3 (HUI3) was performed...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28668955/influence-of-sex-and-age-on-posterior-semicircular-canal-thickness
#9
Jaime Whyte, M Teresa Tejedor, Luis V Monteagudo, Ana Whyte, Ana I Cisneros, Rafael Crovetto, Jesus J Fraile, Miguel A Crovetto
OBJECTIVE: The aim of this study is to determine whether sex and age influence posterior semicircular canal (PSC) thickness. METHODS: This observational study was conducted in 3 tertiary hospitals. The minimal distance between the PSC and the posterior cranial fossa (PSC thickness) was estimated by thin-section multidetector row computed axial tomography (CAT) scan of the temporal bones. Nonselected consecutive patients of all ages (607 temporal bones) were considered...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28641288/the-crista-fenestra-and-its-impact-on-the-surgical-approach-to-the-scala-tympani-during-cochlear-implantation
#10
Roberto D Angeli, Joel Lavinsky, Enio T Setogutti, Luiz Lavinsky
OBJECTIVE: The aim of this work was to describe the dimensions of the crista fenestra and determine its presence by means of high-resolution computed tomography (CT) for the purpose of cochlear implantation via the round window approach. METHODS: A series of 10 adult human temporal bones underwent high-resolution CT scanning and were further dissected for microscopic study of the round window niche. RESULTS: In all of the specimens, the round window membrane was fully visualized after the complete removal of bony overhangs...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28628917/anatomical-characteristics-of-facial-nerve-and-cochlea-interaction
#11
Nadine Schart-Morén, Sune Larsson, Helge Rask-Andersen, Hao Li
OBJECTIVE: The aim was to study the relationship between the labyrinthine portion (LP) of the facial canal and the cochlea in human inner ear molds and temporal bones using micro-CT and 3D rendering. A reduced cochlea-facial distance may spread electric currents from the cochlear implant to the LP and cause facial nerve stimulation. Influencing factors may be the topographic anatomy and otic capsule properties. METHODS: An archival collection of human temporal bones underwent micro-CT and 3D reconstruction...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28601886/auna2-a-novel-type-of-non-syndromic-slowly-progressive-auditory-synaptopathy-auditory-neuropathy-with-autosomal-dominant-inheritance
#12
Ruth Lang-Roth, Eva Fischer-Krall, Cornelia Kornblum, Gudrun Nürnberg, Dieter Meschede, Ingrid Goebel, Peter Nürnberg, Dirk Beutner, Christian Kubisch, Martin Walger, Alexander E Volk
BACKGROUND: Auditory synaptopathy/neuropathy (AS/AN) is a heterogeneous disorder, which may be caused by environmental factors like postnatal hyperbilirubinemia or by genetic factors. The genetic forms are subdivided into syndromic and non-syndromic types, and show different inheritance patterns with a strong preponderance of autosomal-recessive forms. To date, only a single locus for non-syndromic autosomal-dominant AS/AN (AUNA1) has been reported in a single family, in which a non-coding DIAPH3 mutation was subsequently described as causative...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28514787/delayed-effect-of-active-pressure-treatment-on-endolymphatic-hydrops
#13
Edoardo Covelli, Luigi Volpini, Francesca Atturo, Anna Teresa Benincasa, Chiara Filippi, Silvia Tarentini, Vania Marrone, Simonetta Monini, Annarita Vestri, Maurizio Barbara
OBJECTIVE: To identify eventual correlations between the effect of low-pressure treatment and endolymphatic hydrops in Ménière patients. MATERIAL AND METHODS: The study group consisted of subjects affected by definite Ménière disease (2015) and a severe degree of disability, who received a ventilation tube with or without a low-pressure treatment before undergoing a surgical procedure (vestibular neurectomy). After the placement of the ventilation tube, the subjects were either left alone with the tube or received 1 month of self-administered low-pressure therapy with a portable device...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28434002/in-situ-hearing-tests-for-the-purpose-of-a-self-fit-hearing-aid
#14
Monique Boymans, Wouter A Dreschler
This study investigated the potential and limitations of a self-fit hearing aid. This can be used in the "developing" world or in countries with large distances between the hearing-impaired subjects and the professional. It contains an on-board tone generator for in situ user-controlled, automated audiometry, and other tests for hearing aid fitting. Twenty subjects with mild hearing losses were involved. In situ audiometry showed a test-retest reliability (SD <3.7 dB) that compared well with the precision of diagnostic audiometry using headphones...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28423381/self-administered-tinnitus-pitch-matching-versus-a-conventional-audiometric-procedure
#15
Tae Su Kim, Natalia Yakunina, Yoon-Jong Ryu, Ik Joo Chung, Eui-Cheol Nam
OBJECTIVE: Obtaining an accurate tinnitus pitch match is an initial and critical requirement for tinnitus evaluation and treatment, particularly for applying tailor-made notched music training. We investigated whether computer-based self-administered tinnitus pitch matching (CSTPM) is comparable with a conventional audiometric procedure (CAP). METHODS: In total, 82 patients (mean age 45.52 years; 42 females) with tonal tinnitus participated. The CAP was performed by the same audiologist using a 2-alternative forced choice method with a frequency range of 0...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28423374/hyperbaric-oxygen-therapy-as-adjuvant-treatment-for-idiopathic-sudden-sensorineural-hearing-loss-after-failure-of-systemic-steroids
#16
Seiji Hosokawa, Ken-Ichi Sugiyama, Goro Takahashi, Yu-Ichi Hashimoto, Kumiko Hosokawa, Satoru Takebayashi, Hiroyuki Mineta
We evaluated the outcomes of and prognostic factors for idiopathic sudden sensorineural hearing loss (ISSNHL) treated with adjuvant hyperbaric oxygen therapy (HBOT). A retrospective review of clinical data was performed for 167 patients with ISSNHL who failed to respond to systemic steroids and were treated by adjuvant HBOT at Shizuoka Saiseikai General Hospital. We analysed the clinical outcomes, the averaged 5-frequency hearing level after systemic steroids, patient age, the interval between post-steroids and pre-HBOT, vertigo as a complication, the presence of diabetes mellitus, smoking history, and hypertension...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/27806358/editorial
#17
Manuel Manrique-Rodríguez, Ángel Ramos-Macías
No abstract text is available yet for this article.
November 3, 2016: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/27806356/speech-perception-and-information-carrying-capacity-for-hearing-aid-users-of-different-ages
#18
Ulrich Hoppe, Thomas Hocke, Alexander Müller, Anne Hast
Hearing impairment in the elderly is usually treated with conventional hearing aids; however, a large number of older people do not achieve sufficient speech recognition with hearing aids. The aim of the study was to describe speech perception with hearing aids in comparison to pure-tone hearing loss and maximum speech recognition scores for phonemically balanced words. Data from 392 hearing aid users with different degrees of hearing loss were evaluated retrospectively. In particular, pure-tone thresholds, the maximum monosyllabic word score, and the monosyllabic word score in quiet at conversational level with a hearing aid were analysed...
November 3, 2016: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/27806354/the-development-of-remote-speech-recognition-tests-for-adult-cochlear-implant-users-the-effect-of-presentation-mode-of-the-noise-and-a-reliable-method-to-deliver-sound-in-home-environments
#19
Feike de Graaff, Elke Huysmans, Obaid Ur Rehman Qazi, Filiep J Vanpoucke, Paul Merkus, S Theo Goverts, Cas Smits
The number of cochlear implant (CI) users is increasing annually, resulting in an increase in the workload of implant centers in ongoing patient management and evaluation. Remote testing of speech recognition could be time-saving for both the implant centers as well as the patient. This study addresses two methodological challenges we encountered in the development of a remote speech recognition tool for adult CI users. First, we examined whether speech recognition in noise performance differed when the steady-state masking noise was presented throughout the test (i...
November 3, 2016: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/27806349/contributing-determinants-to-hearing-loss-in-elderly-men-and-women-results-from-the-population-based-rotterdam-study
#20
Stephanie C Rigters, Mick Metselaar, Marjan H Wieringa, Robert J Baatenburg de Jong, Albert Hofman, André Goedegebure
To contribute to a better understanding of the etiology in age-related hearing loss, we carried out a cross-sectional study of 3,315 participants (aged 52-99 years) in the Rotterdam Study, to analyze both low- and high-frequency hearing loss in men and women. Hearing thresholds with pure-tone audiometry were obtained, and other detailed information on a large number of possible determinants was collected. Hearing loss was associated with age, education, systolic blood pressure, diabetes mellitus, body mass index, smoking and alcohol consumption (inverse correlation)...
November 3, 2016: Audiology & Neuro-otology
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