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Audiology & Neuro-otology

Sampath Chandra Prasad, Gianluca Piras, Enrico Piccirillo, Abdelkader Taibah, Alessandra Russo, Jingchun He, Mario Sanna
OBJECTIVE: To review the classification and management of petrous bone cholesteatomas (PBCs) at our center and the outcomes of facial nerve (FN) management in these lesions. METHODS: This was a retrospective study. The setting was a quaternary referral center for skull base pathology in Italy. A total of 200 patients with 201 PBCs were included in the study. All patients diagnosed radiologically with PBCs were classified according to the Sanna classification. All patients were surgically treated and followed up with radiology...
October 7, 2016: Audiology & Neuro-otology
Takefumi Kamakura, Makoto Kondo, Yoshihisa Koyama, Yukiko Hanada, Yusuke Ishida, Yukiko Nakamura, Takahiro Yamada, Yasumitsu Takimoto, Tadashi Kitahara, Yoshiyuki Ozono, Arata Horii, Takao Imai, Hidenori Inohara, Shoichi Shimada
Transient receptor potential vanilloid (TRPV) 4 is a nonselective cation channel expressed in sensory neurons such as those in the dorsal root and trigeminal ganglia, kidney, and inner ear. TRPV4 is activated by mechanical stress, heat, low osmotic pressure, low pH, and phorbol derivatives such as 4α-phorbol 12,13-didecanoate (4α-PDD). We investigated the expression of TRPV4 in rat vestibular ganglion (VG) neurons. The TRPV4 gene was successfully amplified from VG neuron mRNA using reverse-transcription polymerase chain reaction...
October 6, 2016: Audiology & Neuro-otology
Daniele De Seta, Yann Nguyen, Antoine Vanier, Evelyne Ferrary, Jean-Pierre Bebear, Benoit Godey, Alain Robier, Michel Mondain, Olivier Deguine, Olivier Sterkers, Isabelle Mosnier
OBJECTIVE: To report the speech performance and sound localization in adult patients 5 years after bilateral simultaneous cochlear implantation and to evaluate the change in speech scores between 1 and 5 years. DESIGN: In this prospective multicenter study, 26 patients were evaluated 5 years after implantation using long straight electrode arrays (MED-EL Combi 40+, standard electrode array, 31 mm). Speech perception was measured using disyllabic words in quiet and noise, with the speech coming from the front and a cocktail party background noise coming from 5 loudspeakers...
September 22, 2016: Audiology & Neuro-otology
Selin Ünsaler, Bora Başaran, Şule Öztürk Sarı, Eyüp Kara, Kemal Değer, Peter John Wormald
OBJECTIVES: To investigate the efficacy of chitosan-dextran hydrogel (CDH) in preventing postoperative adhesions between the tympanic membrane (TM) and intratympanic structures, and to evaluate its ototoxicity in an animal study. METHODS: In the first step, ototoxicity was evaluated with 7 male albino guinea pigs (GPs) via auditory brainstem responses (ABR) before and 4 weeks after unilateral intratympanic injection of CDH and saline solution contralaterally. In the second step, 12 GPs underwent bilateral ear surgery...
September 2, 2016: Audiology & Neuro-otology
Mohammad Waheed El-Anwar, Said Abdelmonem, Ebtessam Nada, Dalia Galhoom, Ahmed A Abdelsameea
OBJECTIVES: To find out the possible protective effect of cilostazol against amikacin-induced ototoxicity. METHODS: This study was carried out on 24 adult male rats classified into 4 equal groups of 6 animals each. (1) The control group was administered saline (1 ml/day, p.o.) for 14 days. (2) The amikacin group was administered amikacin (200 mg/kg, i.m.) once daily for 14 days. (3) The cilostazol-amikacin (14 days) group was administered cilostazol (30 mg/kg, p...
August 30, 2016: Audiology & Neuro-otology
Louis B Kratchman, Daniel Schuster, Mary S Dietrich, Robert F Labadie
Tissue trauma is a frequent complication of cochlear implantation (CI) surgery, but the relationship between intracochlear trauma, electrode insertion forces, and surgeons' ability to perceive these forces is poorly understood. In this study, we simulated CI surgery using a benchtop apparatus to repeatedly apply small forces to the subjects' hands while reducing the variability in their hand movements. We used a psychophysical testing procedure to estimate the force perception thresholds of 10 otologic surgeons and found a median threshold of 20...
August 30, 2016: Audiology & Neuro-otology
Hillary A Snapp, Kari E Morgenstein, Fred F Telischi, Simon Angeli
Transcranial attenuation (TA) of bone-conducted sound has a high degree of variability by frequency and subject, which may play a role in the objective benefit of individuals with single-sided deafness (SSD) treated with a bone-anchored implant (BAI). This study sought to determine whether TA is predictive of benefit in individuals with SSD who receive a BAI. Adult, English-speaking patients with unilateral profound sensorineural hearing loss who underwent a BAI evaluation were included for study. Absolute TA values were consistent with previously published reports...
August 17, 2016: Audiology & Neuro-otology
Rashid Sheikh, Hassan Haidar, Hassanin Abdulkarim, Waqar Aslam, Aisha Larem, Ali Alsaadi, Abdulsalam Alqahtani
OBJECTIVE: Ossicular discontinuity may result from chronic suppurative otitis media and is usually detected intraoperatively. Our objective is to determine whether a preoperative audiogram can preoperatively predict the presence or absence of ossicular discontinuity. METHODS: A cross-sectional study was prospectively run on our patients, aged 12-75 years, ultimately operated on for chronic suppurative otitis media. Preoperative audiograms were analyzed to measure frequency-specific air-bone gap (ABG) cutoff values...
August 5, 2016: Audiology & Neuro-otology
Robert Allan Sharpe, Elizabeth L Camposeo, Wasef K Muzaffar, Meredith A Holcomb, Judy R Dubno, Ted A Meyer
The objective of this study was to examine how age and implanted ear contribute to functional outcomes with cochlear implantation (CI). A retrospective review was performed on 96 adults who underwent unilateral CI. Older adults with right-ear implants had higher Hearing in Noise Test (HINT) scores at 1 year by 10.3% (p = 0.06). When adjusted to rationalized arcsine units (rau), right-ear HINT scores in older adults were higher by 12.1 rau (p = 0.04). Older adults had an 8.9% advantage on the right side compared to the left in post- versus preimplant scores for consonant-vowel nucleus-consonant words (p = 0...
July 23, 2016: Audiology & Neuro-otology
Thomas Zahnert, Hubert Löwenheim, Dirk Beutner, Rudolf Hagen, Arneborg Ernst, Hans-Wilhelm Pau, Thorsten Zehlicke, Hilke Kühne, Natascha Friese, Anke Tropitzsch, Jan-Christoffer Lüers, Robert Mlynski, Ingo Todt, Karl-Bernd Hüttenbrink
OBJECTIVE: To evaluate the safety and effectiveness of round window (RW), oval window (OW), CliP and Bell couplers for use with an active middle ear implant. METHODS: This is a multicenter, long-term, prospective trial with consecutive enrollment, involving 6 university hospitals in Germany. Bone conduction, air conduction, implant-aided warble-tone thresholds and Freiburger monosyllable word recognition scores were compared with unaided preimplantation results in 28 moderate-to-profound hearing-impaired patients after 12 months of follow-up...
June 29, 2016: Audiology & Neuro-otology
A R Fetoni, A Ruggiero, D Lucidi, E De Corso, B Sergi, G Conti, G Paludetti
Platinum compounds constitute the standard treatment for solid tumors in pediatric oncology. The purpose of this study is to assess the impact of platinum compounds in the development of ototoxicity in children following chemotherapy. This study included 160 patients treated with cisplatin and carboplatin for malignant solid diseases from 2007 to 2014. Their audiograms were classified according to the Boston SIOP ototoxicity scale. Twenty-five percent of the children treated with platinum compounds developed ototoxicity...
June 11, 2016: Audiology & Neuro-otology
Jessica Vitkovic, Carmen Le, Su-Ling Lee, Ross A Clark
This study investigated the hypothesis that a hearing 'map' of our surroundings is used to maintain balance control. We investigated the effects of sound on postural sway using centre of pressure analysis in 50 subjects with normal hearing, 28 with hearing loss and 19 with vestibular dysfunction. The acoustic environments utilized sound cues that were either present or absent. It was found that auditory cues are utilized by subjects with normal hearing to improve postural sway. The ability to utilize sound for postural control is diminished when there is a hearing loss, but this appears to be overcome by the use of a hearing aid...
June 2, 2016: Audiology & Neuro-otology
Josephine W I van Nierop, Rebecca R Snabel, Margreet Langereis, Ronald J E Pennings, Ronald J C Admiraal, Emmanuel A M Mylanus, Henricus P M Kunst
OBJECTIVE: To analyse the benefit of cochlear implantation in young deaf children with Waardenburg syndrome (WS) compared to a reference group of young deaf children without additional disabilities. METHOD: A retrospective study was conducted on children with WS who underwent cochlear implantation at the age of 2 years or younger. The post-operative results for speech perception (phonetically balanced standard Dutch consonant-vocal-consonant word lists) and language comprehension (the Reynell Developmental Language Scales, RDLS), expressed as a language quotient (LQ), were compared between the WS group and the reference group by using multiple linear regression analysis...
2016: Audiology & Neuro-otology
Kristen Ricchetti-Masterson, Molly Aldridge, John Logie, Nittaya Suppapanya, Suzanne F Cook
Recent studies on the epidemiology of the inner-ear disorder Ménière's disease (MD) use disparate methods for sample selection, case identification and length of observation. Prevalence estimates vary geographically from 17 to 513 cases per 100,000 people. We explored the impact of case detection strategies and observation periods in estimating the prevalence of MD in the USA, using data from a large insurance claims database. Using case detection strategies of ≥1, ≥2 and ≥3 ICD-9 claim codes for MD within a 1-year period, the 2012 prevalence estimates were 66, 27 and 14 cases per 100,000 people, respectively...
2016: Audiology & Neuro-otology
Hyun Soo Cho, Kyu-Yup Lee, Hongsoo Choi, Jeong Hun Jang, Sang Heun Lee
The aim of this study was to investigate the efficacy of preoperative and intraoperative steroid administration for inner ear protection in cochlear implantation (CI). Nineteen subjects who underwent CI were included in the study, and 10 subjects were enrolled as controls (steroid-administered group, n = 19; control group, n = 10). Dexamethasone (dexamethasone sodium phosphate, 5 mg/ml) was systemically administered preoperatively (1 ml) and topically applied during CI (0.5 ml). The extent of hearing preservation (HP) after CI and the change in the bithermal caloric response were evaluated...
2016: Audiology & Neuro-otology
Dong-Kee Kim, In Seok Moon, Hye Jin Lim, Shin-Young Yoo, Kyung Wook Heo, Seong-Cheon Bae, Kyung Ray Moon, Jong Joo Lee, Yun-Hoon Choung, Shi-Nae Park
OBJECTIVE: To investigate the time course of tinnitus changes in patients receiving cochlear implantation (CI) in a prospective, multicenter setting and to determine related factors. MATERIALS AND METHODS: A total of 79 adult patients who underwent CI were included in this study. We used the same questionnaires sequentially 5 times. The questionnaires included the Visual Analog Scale (VAS) for tinnitus severity, the Tinnitus Handicap Inventory (THI), Beck's Depression Index (BDI), and the Brief Encounter Psychosocial Instrument (BEPSI) for stress assessment...
2016: Audiology & Neuro-otology
Gislaine Richter Minhoto Wiemes, Rogério Hamerschmidt, Ana Tereza Ramos Moreira, Rogério de Fraga, Sérgio Bernardo Tenório, Bettina Carvalho
OBJECTIVE: To analyze auditory nerve recovery function (REC), comparing the results after local anesthesia and sedation with those after general anesthesia. METHODS: This was a prospective, cross-sectional and descriptive study in a tertiary referral center hospital. We included all patients (37 ears) who underwent surgery for cochlear implant under either general anesthesia or local anesthesia and sedation during 3 years. REC was measured according to the function of 3 components, 'T0', 'A' and 'tau', and was taken for 3 cochlear electrodes (apical, medial and basal)...
2016: Audiology & Neuro-otology
Daniele Bernardeschi, Francesca Yoshie Russo, Yann Nguyen, Eric Vicault, Jonathan Flament, Deborah Bernou, Olivier Sterkers, Isabelle Mosnier
Single-sided deafness (SSD) represents one of the most difficult audiological conditions to rehabilitate. The aim of this prospective study was to evaluate the audiological benefits and quality of life of patients affected by SSD who had previously been users of the Alpha 1® when upgrading them to the Sophono Alpha 2® external processor (Boulder, Colo., USA). Nine patients were included in the study. They underwent physical examination, free-field speech audiometry at 40 and 60 dB, a hearing-in-noise test (Hirsch's test and the squelch test), the Glasgow Benefit Inventory (GBI) questionnaire, and a specific questionnaire on patient satisfaction with Alpha 1...
2016: Audiology & Neuro-otology
Akinori Kashio, Viral D Tejani, Rachel A Scheperle, Carolyn J Brown, Paul J Abbas
In this study we measured the electrically evoked compound action potential (ECAP) from different recording electrodes in the cochlea. Under the assumption that different response latencies may be the result of differences in the neural population contributing to the response, we assessed the relationship between neural response latency and spread of excitation. First, we evaluated changes in N1 latency when the recording electrode site was varied. Second, we recorded channel interaction functions using a forward masking technique but with recording electrodes at different intracochlear locations...
2016: Audiology & Neuro-otology
Michael F Dorman, Louise H Loiselle, Sarah J Cook, William A Yost, René H Gifford
OBJECTIVE: Our primary aim was to determine whether listeners in the following patient groups achieve localization accuracy within the 95th percentile of accuracy shown by younger or older normal-hearing (NH) listeners: (1) hearing impaired with bilateral hearing aids, (2) bimodal cochlear implant (CI), (3) bilateral CI, (4) hearing preservation CI, (5) single-sided deaf CI and (6) combined bilateral CI and bilateral hearing preservation. DESIGN: The listeners included 57 young NH listeners, 12 older NH listeners, 17 listeners fit with hearing aids, 8 bimodal CI listeners, 32 bilateral CI listeners, 8 hearing preservation CI listeners, 13 single-sided deaf CI listeners and 3 listeners with bilateral CIs and bilateral hearing preservation...
2016: Audiology & Neuro-otology
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