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Audiology & Neuro-otology

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https://www.readbyqxmd.com/read/29130955/tinnitus-and-hearing-survey-a-polish-study-of-validity-and-reliability-in-a-clinical-population
#1
Danuta Raj-Koziak, Elzbieta Gos, Joanna Rajchel, Adam Piłka, Henryk Skarżyński, Joanna Rostkowska, Piotr H Skarzynski
This study investigates the psychometric properties of the Polish version of the Tinnitus and Hearing Survey (THS-POL), which is a tool for evaluating what proportion of patients' tinnitus is due to hearing problems and what proportion is specifically due to the tinnitus. The THS-POL was created using the translation-backtranslation method. Study participants completed the THS-POL twice over a period of 3 days. The test-retest analysis shows excellent strength of correlations (THS-POL subscale A r = 0.89, subscale B r = 0...
November 11, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29084395/electrophysiological-evidence-of-the-basilar-membrane-travelling-wave-and-frequency-place-coding-of-sound-in-cochlear-implant-recipients
#2
Luke Campbell, Christofer Bester, Claire Iseli, David Sly, Adrian Dragovic, Anthony W Gummer, Stephen O'Leary
AIM: To obtain direct evidence for the cochlear travelling wave in humans by performing electrocochleography from within the cochlea in subjects implanted with an auditory prosthesis. BACKGROUND: Sound induces a travelling wave that propagates along the basilar membrane, exhibiting cochleotopic tuning with a frequency-dependent phase delay. To date, evoked potentials and psychophysical experiments have supported the presence of the travelling wave in humans, but direct measurements have not been made...
October 31, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29080887/evaluation-of-vestibular-functions-in-patients-with-vogt-koyanagi-harada-disease
#3
Keishi Fujiwara, Shinya Morita, Kimiko Hoshino, Atsushi Fukuda, Yuji Nakamaru, Akihiro Homma
Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Subjective symptoms such as dizziness or vertigo and the results of various vestibular examinations including nystagmus testing, caloric testing, and vestibular-evoked myogenic potential (VEMP) testing were investigated...
October 28, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29059669/clinical-investigation-of-the-nucleus-slim-modiolar-electrode
#4
Antje Aschendorff, Robert Briggs, Goetz Brademann, Silke Helbig, Joachim Hornung, Thomas Lenarz, Mathieu Marx, Angel Ramos, Timo Stöver, Bernard Escudé, Chris J James
AIMS: The Nucleus CI532 cochlear implant incorporates a new precurved electrode array, i.e., the Slim Modiolar electrode (SME), which is designed to bring electrode contacts close to the medial wall of the cochlea while avoiding trauma due to scalar dislocation or contact with the lateral wall during insertion. The primary aim of this prospective study was to determine the final position of the electrode array in clinical cases as evaluated using flat-panel volume computed tomography...
October 24, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29049998/endoplasmic-reticulum-stress-is-involved-in-cochlear-cell-apoptosis-in-a-cisplatin-induced-ototoxicity-rat-model
#5
Shimin Zong, Tianyi Liu, Fangmin Wan, Pei Chen, Pan Luo, Hongjun Xiao
Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When ER stress occurs, the unfolded protein response (UPR) is subsequently activated to restore ER proteostasis. However, severe ER stress leads to apoptosis. Recent studies have suggested that cisplatin cytotoxicity may be related to ER stress. The purpose of this study was to determine whether ER stress participates in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model and to also determine the possible relationship between ER stress and hearing loss...
October 20, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28992622/a-subjective-rating-scale-for-initial-assessment-of-sudden-unilateral-sensorineural-hearing-loss
#6
Omer J Ungar, Oren Cavel, Yahav Oron, Anat Wengier, Oshri Wasserzug, Ophir Handzel
OBJECTIVE: To examine the value of a subjective numerical rating scale (NRS) in the initial evaluation of patients suspected of suffering from unilateral sudden sensorineural hearing loss (SSNHL) until a formal audiogram is available. STUDY DESIGN: Prospective noncontrolled clinical study. METHODS: Thirty-one consecutive patients referred to the emergency department due to suspected unilateral SSNHL and with no other aural pathology by history or physical examination were enrolled...
October 10, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28982105/impact-of-lipid-inflammatory-oxidative-metabolism-on-auditory-skills-after-hearing-aid-fitting-in-the-elderly
#7
Alexandre Hundertmarck Lessa, Ivana Beatrice Mânica da Cruz, Maria Fernanda Manica-Cattani, Rafael Noal Moresco, Marta Maria Medeiros Frescura Duarte, Maristela Julio Costa
This study aimed to assess whether lipid-inflammatory-oxidative metabolism influences auditory processing skills, and whether they function in changing auditory performance after hearing aid fitting in the elderly. Twelve subjects with bilateral hearing loss were submitted to blood tests (to check their lipid-inflammatory-oxidative metabolism) and auditory processing skill tests. After 3 months of using the hearing aids, their auditory skills were re-evaluated and the data were correlated statistically. Oxidative stress levels mainly showed some impact on auditory temporal processing; such a relation and others should best be examined in further studies with larger populations...
October 6, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28968605/expression-profiling-of-micrornas-in-the-inner-ear-of-elderly-people-by-real-time-pcr-quantification
#8
Kuwon Sekine, Tomohiro Matsumura, Toshihiro Takizawa, Yurika Kimura, Shiho Saito, Kyoko Shiiba, Susumu Shindo, Kimihiro Okubo, Tetsuo Ikezono
The molecular mechanisms underlying age-related hearing loss are unknown, and currently, there is no treatment for this condition. Recent studies have shown that microRNAs (miRNAs) and age-related diseases are intimately linked, suggesting that some miRNAs may present attractive therapeutic targets. In this study, we obtained 8 human temporal bones from 8 elderly subjects at brain autopsy in order to investigate the expression profile of miRNAs in the inner ear with miRNA arrays. A mean of 478 different miRNAs were expressed in the samples, of which 348 were commonly expressed in all 8 samples...
September 30, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28889125/brimonidine-protects-auditory-hair-cells-from-in-vitro-induced-toxicity-of-gentamicin
#9
Maurizio Cortada, Soledad Levano, Daniel Bodmer
Brimonidine, an alpha-2 adrenergic receptor (α2-AR) agonist, has neuroprotective effects in the visual system and in spiral ganglion neurons. Auditory hair cells (HCs) express all 3 α2-AR subtypes, but their roles in HCs remain unknown. This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined...
September 9, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28848089/histopathology-of-the-human-inner-ear-in-the-cogan-syndrome-with-cochlear-implantation
#10
Takefumi Kamakura, Daniel J Lee, Barbara S Herrmann, Joseph B Nadol
The Cogan syndrome is a rare disorder characterized by nonsyphilitic interstitial keratitis and audiovestibular symptoms. Profound sensorineural hearing loss has been reported in approximately half of the patients with the Cogan syndrome resulting in candidacy for cochlear implantation in some patients. The current study is the first histopathologic report on the temporal bones of a patient with the Cogan syndrome who during life underwent bilateral cochlear implantation. Preoperative MRI revealed tissue with high density in the basal turns of both cochleae and both vestibular systems consistent with fibrous tissue due to labyrinthitis...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28848077/perception-of-iterated-rippled-noise-periodicity-in-cochlear-implant-users
#11
Luise Wagner, Stefan K Plontke, Torsten Rahne
Pitch perception is more challenging for individuals with cochlear implants (CIs) than normal-hearing subjects because the signal processing by CIs is restricted. Processing and perceiving the periodicity of signals may contribute to pitch perception. Whether individuals with CIs can discern pitch within an iterated rippled noise (IRN) signal is still unclear. In a prospective controlled psychoacoustic study with 34 CI users and 15 normal-hearing control subjects, the difference limen between IRN signals with different numbers of iterations was measured...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28817812/the-mir-34a-bcl-2-pathway-contributes-to-auditory-cortex-neuron-apoptosis-in-age-related-hearing-loss
#12
Qiuhong Huang, Yongkang Ou, Hao Xiong, Haidi Yang, Zhigang Zhang, Suijun Chen, Yongyi Ye, Yiqing Zheng
HYPOTHESIS: The miR-34a/Bcl-2 signaling pathway may play a role in the mechanisms related to age-related hearing loss (AHL) in the auditory cortex. BACKGROUND: The auditory cortex plays a key role in the recognition and processing of complex sound. It is difficult to explain why patients with AHL have poor speech recognition, so increasing numbers of studies have focused on its central change. Although micro (mi)RNAs in the central nervous system have recently been increasingly reported to be associated with age-related diseases, the molecular mechanisms of AHL in the auditory cortex are not fully understood...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28793285/resistance-of-gerbil-auditory-function-to-reversible-decrease-in-cochlear-blood-flow
#13
Fahd El Afia, Fabrice Giraudet, Laurent Gilain, Thierry Mom, Paul Avan
The objective was to design in gerbils a model of reversible decrease in cochlear blood flow (CBF) and analyze its influence on cochlear function. In Mongolian gerbils injected with ferromagnetic microbeads, a magnet placed near the porus acusticus allowed CBF to be manipulated. The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. In 13 of the 20 successfully injected gerbils, stable CBF reduction was obtained for 11.5 min on average. The CM was affected only when CBF fell to less than 60% of its baseline, yet remained >40% of its initial level in about 2/3 of such cases...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28738350/unilateral-sensorineural-hearing-loss-medical-context-and-etiology
#14
Antoine Paul, Sandrine Marlin, Marine Parodi, Isabelle Rouillon, Joanne Guerlain, Véronique Pingault, Vincent Couloigner, Erea Noel Garabedian, Françoise Denoyelle, Natalie Loundon
OBJECTIVE: Unilateral sensorineural hearing loss (USNHL) is known to impact on school performance and social skills during childhood, but the etiologies remain unclear. The aim of this study was to assess various etiologies and to study the clinical contexts in this population. METHODS: The study is a retrospective review. Characteristics of hearing loss (HL), audiometric parameters, imaging, and genetic and medical contexts were analyzed. RESULTS: Eighty children were included...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28723686/population-based-study-on-the-epidemiology-of-m%C3%A3-ni%C3%A3-re-s-disease
#15
Saskia G Bruderer, Daniel Bodmer, Nadja A Stohler, Susan S Jick, Christoph R Meier
BACKGROUND AND OBJECTIVE: Ménière's disease (MD) is a disorder of the inner ear typically showing recurrent acute episodes of vertigo, hearing loss, and tinnitus. Epidemiologic studies on MD are scarce. We assessed the incidence rates (IRs) of MD and describe the characteristics of MD cases, comparing them to control patients without recorded evidence of MD. STUDY DESIGN: We conducted a retrospective population-based follow-up study and a nested case-control analysis using data from the UK-based Clinical Practice Research Datalink...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28719901/patient-related-benefits-for-adults-with-cochlear-implantation-a-multicultural-longitudinal-observational-study
#16
Thomas Lenarz, Lida Muller, Hanna Czerniejewska-Wolska, Hector Vallés Varela, César Orús Dotú, Marcin Durko, Alicia Huarte Irujo, Bartosz Piszczatowski, Marek Zadrożniak, Colin Irwin, Petra L Graham, Josie Wyss
OBJECTIVES: To assess subjectively perceived, real-world benefits longitudinally for unilateral cochlear implant (CI) recipients in a multinational population treated routinely. To identify possible predictors of self-reported benefits. DESIGN: This was a prospective, multicenter, repeated-measures study. Self-assessment of performance at preimplantation and postimplantation at 1, 2, and 3 years using standardized, validated, local language versions of the Speech, Spatial, and Qualities of Hearing Scale (SSQ), and the Health Utilities Index Mark 3 (HUI3) was performed...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28668955/influence-of-sex-and-age-on-posterior-semicircular-canal-thickness
#17
Jaime Whyte, M Teresa Tejedor, Luis V Monteagudo, Ana Whyte, Ana I Cisneros, Rafael Crovetto, Jesus J Fraile, Miguel A Crovetto
OBJECTIVE: The aim of this study is to determine whether sex and age influence posterior semicircular canal (PSC) thickness. METHODS: This observational study was conducted in 3 tertiary hospitals. The minimal distance between the PSC and the posterior cranial fossa (PSC thickness) was estimated by thin-section multidetector row computed axial tomography (CAT) scan of the temporal bones. Nonselected consecutive patients of all ages (607 temporal bones) were considered...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28641288/the-crista-fenestra-and-its-impact-on-the-surgical-approach-to-the-scala-tympani-during-cochlear-implantation
#18
Roberto D Angeli, Joel Lavinsky, Enio T Setogutti, Luiz Lavinsky
OBJECTIVE: The aim of this work was to describe the dimensions of the crista fenestra and determine its presence by means of high-resolution computed tomography (CT) for the purpose of cochlear implantation via the round window approach. METHODS: A series of 10 adult human temporal bones underwent high-resolution CT scanning and were further dissected for microscopic study of the round window niche. RESULTS: In all of the specimens, the round window membrane was fully visualized after the complete removal of bony overhangs...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28628917/anatomical-characteristics-of-facial-nerve-and-cochlea-interaction
#19
Nadine Schart-Morén, Sune Larsson, Helge Rask-Andersen, Hao Li
OBJECTIVE: The aim was to study the relationship between the labyrinthine portion (LP) of the facial canal and the cochlea in human inner ear molds and temporal bones using micro-CT and 3D rendering. A reduced cochlea-facial distance may spread electric currents from the cochlear implant to the LP and cause facial nerve stimulation. Influencing factors may be the topographic anatomy and otic capsule properties. METHODS: An archival collection of human temporal bones underwent micro-CT and 3D reconstruction...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28601886/auna2-a-novel-type-of-non-syndromic-slowly-progressive-auditory-synaptopathy-auditory-neuropathy-with-autosomal-dominant-inheritance
#20
Ruth Lang-Roth, Eva Fischer-Krall, Cornelia Kornblum, Gudrun Nürnberg, Dieter Meschede, Ingrid Goebel, Peter Nürnberg, Dirk Beutner, Christian Kubisch, Martin Walger, Alexander E Volk
BACKGROUND: Auditory synaptopathy/neuropathy (AS/AN) is a heterogeneous disorder, which may be caused by environmental factors like postnatal hyperbilirubinemia or by genetic factors. The genetic forms are subdivided into syndromic and non-syndromic types, and show different inheritance patterns with a strong preponderance of autosomal-recessive forms. To date, only a single locus for non-syndromic autosomal-dominant AS/AN (AUNA1) has been reported in a single family, in which a non-coding DIAPH3 mutation was subsequently described as causative...
2017: Audiology & Neuro-otology
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