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Journal of Biomedical Optics

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https://www.readbyqxmd.com/read/28698890/change-of-tumor-vascular-reactivity-during-tumor-growth-and-postchemotherapy-observed-by-near-infrared-spectroscopy
#1
Songhyun Lee, Hyeryun Jeong, Myeongsu Seong, Jae Gwan Kim
Breast cancer is one of the most common cancers in females. To monitor chemotherapeutic efficacy for breast cancer, medical imaging systems such as x-ray mammography, computed tomography, magnetic resonance imaging, and ultrasound imaging have been used. Currently, it can take up to 3 to 6 weeks to see the tumor response from chemotherapy by monitoring tumor volume changes. We used near-infrared spectroscopy (NIRS) to predict breast cancer treatment efficacy earlier than tumor volume changes by monitoring tumor vascular reactivity during inhalational gas interventions...
December 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28698889/blue-diode-laser-versus-traditional-infrared-diode-laser-and-quantic-molecular-resonance-scalpel-clinical-and-histological-findings-after-excisional-biopsy-of-benign-oral-lesions
#2
Margherita Gobbo, Rossana Bussani, Giuseppe Perinetti, Katia Rupel, Lorenzo Bevilaqua, Giulia Ottaviani, Matteo Biasotto
This study aims to compare the use of the innovative blue diode laser (BLUE group) with two traditional surgical techniques: the infrared diode laser (IR group) and the quantic molecular resonance scalpel (QMR group) in the excision of benign oral lesions. Ninety-three patients underwent surgical excision of a benign oral lesion and were followed up for 30 days for pain (0 to 10 visual analogue scale), bleeding, and painkillers’ assumption (yes/no). A blind pathologist evaluated the thermal damage along the cutting margin...
December 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28933070/variations-in-the-endogenous-fluorescence-of-rabbit-corneas-after-mechanical-property-alterations
#3
Antonio Ortega-Martinez, Genna Touchette, Hong Zhu, Irene E Kochevar, Walfre Franco
Keratoconus is an eye disease in which the cornea progressively deforms due to loss of cornea mechanical rigidity, and thus causes deterioration of visual acuity. Techniques to characterize the mechanical characteristics of the cornea are important to better monitor changes and response to treatments. To investigate the feasibility of using the endogenous fluorescence of cornea for monitoring alterations of its mechanical rigidity, linear tensiometry was used to quantitate stiffness and Young's modulus (YM) after treatments that increase cornea stiffness (collagen photocross-linking) or decrease stiffness (enzymatic digestion)...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28933069/optical-tomographic-imaging-for-breast-cancer-detection
#4
Wenxiang Cong, Xavier Intes, Ge Wang
Diffuse optical breast imaging utilizes near-infrared (NIR) light propagation through tissues to assess the optical properties of tissues for the identification of abnormal tissue. This optical imaging approach is sensitive, cost-effective, and does not involve any ionizing radiation. However, the image reconstruction of diffuse optical tomography (DOT) is a nonlinear inverse problem and suffers from severe illposedness due to data noise, NIR light scattering, and measurement incompleteness. An image reconstruction method is proposed for the detection of breast cancer...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28929643/demons-registration-for-in-vivo-and-deformable-laser-scanning-confocal-endomicroscopy
#5
Wei-Ming Chiew, Feng Lin, Hock Soon Seah
A critical effect found in noninvasive in vivo endomicroscopic imaging modalities is image distortions due to sporadic movement exhibited by living organisms. In three-dimensional confocal imaging, this effect results in a dataset that is tilted across deeper slices. Apart from that, the sequential flow of the imaging-processing pipeline restricts real-time adjustments due to the unavailability of information obtainable only from subsequent stages. To solve these problems, we propose an approach to render Demons-registered datasets as they are being captured, focusing on the coupling between registration and visualization...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28929642/facilitating-in-vivo-tumor-localization-by-principal-component-analysis-based-on-dynamic-fluorescence-molecular-imaging
#6
Yang Gao, Maomao Chen, Junyu Wu, Yuan Zhou, Chuangjian Cai, Daliang Wang, Jianwen Luo
Fluorescence molecular imaging has been used to target tumors in mice with xenograft tumors. However, tumor imaging is largely distorted by the aggregation of fluorescent probes in the liver. A principal component analysis (PCA)-based strategy was applied on the in vivo dynamic fluorescence imaging results of three mice with xenograft tumors to facilitate tumor imaging, with the help of a tumor-specific fluorescent probe. Tumor-relevant features were extracted from the original images by PCA and represented by the principal component (PC) maps...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28925109/red-fluorescence-imaging-for-dental-plaque-detection-and-quantification-pilot-study
#7
Zhao Liu, Juliana Gomez, Soniya Khan, Debbie Peru, Roger Ellwood
The red fluorescence of dental plaque originating from porphyrins in oral bacteria may allow visualization, detection, and scoring of plaque without disclosing agents. Two studies were conducted. The first included 24 healthy participants who abstained from oral hygiene for 24 h. Dental plaque was collected from tooth surfaces, and a 10% solution was prepared. These were scanned by a molecular spectrometer to identify the optimum excitation and emission wavelengths of plaque for developing a red fluorescence imaging system...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28925108/development-of-a-reliable-and-reproducible-phantom-manufacturing-method-using-silica-microspheres-in-silicone
#8
Charlotte Maughan Jones, Peter R Munro
Optically scattering phantoms composed of silica microspheres embedded in an optically clear silicone matrix were manufactured using a previously developed method. Multiple problems, such as sphere aggregation, adsorption to the cast, and silicone shrinkage, were, however, frequently encountered. Solutions to these problems were developed and an improved method, incorporating these solutions, is presented. The improved method offers excellent reliability and reproducibility for creating phantoms with uniform scattering coefficient...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28925107/formulation-of-long-wavelength-indocyanine-green-nanocarriers
#9
Vikram J Pansare, William J Faenza, Hoang Lu, Douglas H Adamson, Robert K Prud'homme
Indocyanine green (ICG), a Food and Drug Administration (FDA)-approved fluorophore with excitation and emission wavelengths inside the "optical imaging window," has been incorporated into nanocarriers (NCs) to achieve enhanced circulation time, targeting, and real-time tracking in vivo. While previous studies transferred ICG exogenously into NCs, here, a one-step rapid precipitation process [flash nanoprecipitation (FNP)] creates ICG-loaded NCs with tunable, narrow size distributions from 30 to 180 nm. A hydrophobic ion pair of ICG-tetraoctylammonium or tetradodecylammonium chloride is formed either in situ during FNP or preformed then introduced into the FNP feed stream...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28914010/fret-based-method-for-evaluation-of-the-efficiency-of-reversible-and-irreversible-sonoporation
#10
Paulius Ruzgys, Mindaugas Tamošiūnas, Vanesa Lukinsone, Saulius Šatkauskas
It is widely known that not all of the treated cells survive after introduction of exogenous molecules via any physical method. Therefore, it is important to develop methods that would allow simultaneous evaluation of both molecular delivery efficiency and cell viability. This study presents Förster resonance energy transfer (FRET)-based method that allows molecular transfer and cell viability evaluation in a single measurement by employing two common fluorescent dyes, namely, ethidium bromide and trypan blue...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28914009/luminescent-diagnostics-of-skin-defects-in-the-near-infrared-range
#11
Yuriy V Alekseev, Valentina D Rumyantseva, Anastasiya S Gorshkova, Anastasiya E Shchelkunova, Igor P Shilov, Andrey V Ivanov
Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28914008/linearly-chirped-fiber-bragg-grating-response-to-thermal-gradient-from-bench-tests-to-the-real-time-assessment-during-in-vivo-laser-ablations-of-biological-tissue
#12
Paola Saccomandi, Ambra Varalda, Riccardo Gassino, Daniele Tosi, Carlo Massaroni, Michele A Caponero, Raoul Pop, Sanzhar Korganbayev, Guido Perrone, Michele Diana, Alberto Vallan, Guido Costamagna, Jacques Marescaux, Emiliano Schena
The response of a fiber optic sensor [linearly chirped fiber Bragg grating (LCFBG)] to a linear thermal gradient applied on its sensing length (i.e., 1.5 cm) has been investigated. After these bench tests, we assessed their feasibility for temperature monitoring during thermal tumor treatment. In particular, we performed experiments during ex vivo laser ablation (LA) in pig liver and in vivo thermal ablation in animal models (pigs). We investigated the following: (i) the relationship between the full width at half maximum of the LCFBG spectrum and the temperature difference among the extremities of the LCFBG and (ii) the relationship between the mean spectrum wavelength and the mean temperature acting on the LCFBG sensing area...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28914007/approximate-p3-solution-for-the-semi-infinite-medium-steady-state-and-time-domain
#13
Xichang Wang
The steady-state solution of the Green's function obtained by the P3 equation in a semi-infinite medium is presented, the proposed solution is a diffusion-based model. Two time-domain solutions are established: one is the solution under extrapolation boundary condition, which we call the optical parameter method, and the other corresponds to the diffusion equation, which we call the double-diffusion coefficient method. The spatial-resolved reflectance and the time-resolved reflectance are calculated. The Monte Carlo simulation is used to verify the P3 equation...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28901055/phantom-based-image-quality-test-methods-for-photoacoustic-imaging-systems
#14
William C Vogt, Congxian Jia, Keith A Wear, Brian S Garra, T Joshua Pfefer
As photoacoustic imaging (PAI) technologies advance and applications arise, there is increasing need for standardized approaches to provide objective, quantitative performance assessment at various stages of the product development and clinical translation process. We have developed a set of performance test methods for PAI systems based on breast-mimicking tissue phantoms containing embedded inclusions. Performance standards for mature imaging modalities [magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound] were used to guide selection of critical PAI image quality characteristics and experimental methods...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28901054/system-calibration-method-for-fourier-ptychographic-microscopy
#15
An Pan, Yan Zhang, Tianyu Zhao, Zhaojun Wang, Dan Dan, Ming Lei, Baoli Yao
Fourier ptychographic microscopy (FPM) is a recently proposed computational imaging technique with both high-resolution and wide field of view. In current FPM imaging platforms, systematic error sources come from aberrations, light-emitting diode (LED) intensity fluctuation, parameter imperfections, and noise, all of which may severely corrupt the reconstruction results with similar artifacts. Therefore, it would be unlikely to distinguish the dominating error from these degraded reconstructions without any preknowledge...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28901053/tissue-characterization-with-depth-resolved-attenuation-coefficient-and-backscatter-term-in-intravascular-optical-coherence-tomography-images
#16
Shengnan Liu, Yohei Sotomi, Jeroen Eggermont, Gaku Nakazawa, Sho Torii, Takeshi Ijichi, Yoshinobu Onuma, Patrick W Serruys, Boudewijn P F Lelieveldt, Jouke Dijkstra
An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different atherosclerotic tissue types with a robust implementation of depth-resolved (DR) approach. Therefore, the DR model is introduced to estimate the attenuation coefficient and further extended to estimate the backscatter-related term in IVOCT images, such that values can be estimated per pixel without predefining any delineation for the estimation...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28901052/noninvasive-three-dimensional-full-field-body-sensor-for-surface-deformation-monitoring-of-human-body-in-vivo
#17
Zhenning Chen, Xinxing Shao, Xiaoyuan He, Jialin Wu, Xiangyang Xu, Jinlin Zhang
Noninvasive, three-dimensional (3-D), full-field surface deformation measurements of the human body are important for biomedical investigations. We proposed a 3-D noninvasive, full-field body sensor based on stereo digital image correlation (stereo-DIC) for surface deformation monitoring of the human body in vivo. First, by applying an improved water-transfer printing (WTP) technique to transfer optimized speckle patterns onto the skin, the body sensor was conveniently and harmlessly fabricated directly onto the human body...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28895317/assessment-of-a-noninvasive-optical-photoplethysmography-imaging-device-with-dynamic-tissue-phantom-models
#18
C Ikenna Nwafor, Kevin D Plant, Darlene R King, Brian P McCall, John J Squiers, Wensheng Fan, J Michael DiMaio, Jeffrey E Thatcher
Noncontact photoplethysmography (PPG) has been studied as a method to provide low-cost, noninvasive, two-dimensional blood oxygenation measurements and medical imaging for a variety of near-surface pathologies. To evaluate this technology in a laboratory setting, dynamic tissue phantoms were developed with tunable parameters that mimic physiologic properties of the skin, including blood vessel volume change, pulse wave frequency, and tissue scattering and absorption. Tissue phantoms were generated using an elastic tubing to represent a blood vessel where the luminal volume could be modulated with a pulsatile fluid flow...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28887875/fast-subsurface-fingerprint-imaging-with-full-field-optical-coherence-tomography-system-equipped-with-a-silicon-camera
#19
Egidijus Auksorius, A Claude Boccara
Images recorded below the surface of a finger can have more details and be of higher quality than the conventional surface fingerprint images. This is particularly true when the quality of the surface fingerprints is compromised by, for example, moisture or surface damage. However, there is an unmet need for an inexpensive fingerprint sensor that is able to acquire high-quality images deep below the surface in short time. To this end, we report on a cost-effective full-field optical coherent tomography system comprised of a silicon camera and a powerful near-infrared LED light source...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28875623/photoacoustic-thermal-flowmetry-with-a-single-light-source
#20
Wei Liu, Bangxin Lan, Leo Hu, Ruimin Chen, Qifa Zhou, Junjie Yao
We report a photoacoustic thermal flowmetry based on optical-resolution photoacoustic microscopy (OR-PAM) using a single laser source for both thermal tagging and photoacoustic excitation. When an optically absorbing medium is flowing across the optical focal zone of OR-PAM, a small volume of the medium within the optical focus is repeatedly illuminated and heated by a train of laser pulses with a high repetition rate. The average temperature of the heated volume at each laser pulse is indicated by the photoacoustic signal excited by the same laser pulse due to the well-established linear relationship between the Grueneisen coefficient and the local temperature...
September 2017: Journal of Biomedical Optics
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