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Helicobacter

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https://www.readbyqxmd.com/read/28940945/effect-of-biopsy-site-on-detection-of-gastric-cancer-high-risk-groups-by-olga-and-olgim-stages
#1
Young-Il Kim, Myeong-Cherl Kook, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Jungnam Joo, Il Ju Choi
BACKGROUND/AIMS: The operative link for gastritis assessment (OLGA) and operative link on gastric intestinal metaplasia assessment (OLGIM) staging systems are recommended to assess the severity of gastritis, but the optimal biopsy sites have not been clearly defined. We aimed to investigate whether the scoring of the OLGA and OLGIM stages was affected by the use of different biopsy sites. METHODS: Between 2014 and 2015, to determine OLGA and OLGIM stages, seven biopsy samples were obtained from the antrum (lesser and greater curvatures [LG] of the antrum and lesser curvature of the angle) and corpus (LG and anterior and posterior walls [AP]) in 247 patients diagnosed with gastritis, gastric adenoma, or adenocarcinoma...
September 22, 2017: Helicobacter
https://www.readbyqxmd.com/read/28940523/epidemiology-of-helicobacter-pylori-infection-in-asymptomatic-schoolchildren-in-bhutan
#2
Sonam Wangda, James M Richter, Pema Kuenzang, Kinley Wangchuk, Tashi Choden, Karma Tenzin, Hoda M Malaty
AIM: Bhutan is a small mountainous country between Tibet and India with relatively homogenous population. According to the World Health Organization, gastric cancer is the most frequent cause of cancer death in Bhutan. This study examined the prevalence of Helicobacter pylori among children in Bhutan with emphasis on water source and living conditions. METHODS: A cross-sectional sero-epidemiologic study was conducted among schoolchildren who attended public schools in Thimphu, Bhutan...
September 22, 2017: Helicobacter
https://www.readbyqxmd.com/read/28940815/helicobacter-pylori-eradication-rates-of-concomitant-and-sequential-therapies-in-korea
#3
Seung Young Kim, Sang Woo Lee, Jung Wan Choe, Sung Woo Jung, Jong Jin Hyun, Young Kul Jung, Ja Seol Koo, Hyung Joon Yim
BACKGROUND: The efficacy of the standard triple therapy for Helicobacter pylori eradication has decreased to an unacceptable level. We aimed to compare the efficacy of sequential and concomitant therapies as for the first-line treatments for H. pylori eradication and analyzed the effect of clarithromycin resistance on the eradication rates. MATERIALS AND METHODS: Four hundred and seventy-eight patients with H. pylori infection were randomly assigned to either concomitant therapy (amoxicillin 1000 mg with clarithromycin 500 mg, metronidazole 500 mg, and pantoprazole 40 mg twice daily for 10 days) or sequential therapy (amoxicillin 1000 mg with pantoprazole 40 mg twice daily for 5 days, followed by clarithromycin 500 mg with metronidazole 500 mg and pantoprazole 40 mg twice daily for 5 days)...
September 21, 2017: Helicobacter
https://www.readbyqxmd.com/read/28913872/high-primary-antibiotic-resistance-of-helicobacter-pylori-strains-isolated-from-dyspeptic-patients-a-prevalence-cross-sectional-study-in-spain
#4
Fernando Macías-García, José Llovo-Taboada, Mario Díaz-López, Iria Bastón-Rey, Juan Enrique Domínguez-Muñoz
BACKGROUND: The rate of H. pylori resistance to different antibiotics is increasing and determines the selection of eradication therapy. The aim of this study was to determine the resistance patterns of H. pylori strains in our area. METHODS: Biopsies from gastric corpus for microbiological culture and antibiotic resistance were obtained in patients undergoing upper gastrointestinal endoscopy for dyspepsia. Selective Agar Pylori for isolation of the bacteria and Agar Mueller-Hinton supplemented with blood to test the sensitivity to antibiotics were used...
September 15, 2017: Helicobacter
https://www.readbyqxmd.com/read/28884937/a-japanese-population-based-meta-analysis-of-vonoprazan-versus-ppi-for-helicobacter-pylori-eradication-therapy-is-superiority-an-illusion
#5
REVIEW
Shou Quan Dong, Tikka Prabhjot Singh, Xin Wei, Huang Yao, Hong Ling Wang
BACKGROUND: Vonoprazan (VPZ) is a novel acid suppressant that has been used in Helicobacter pylori (H. pylori) eradication therapies in recent years. However, the efficacy and safety of VPZ vs proton-pump inhibitor (PPI) in H. pylori eradication therapies remain controversial. OBJECTIVE: To perform a meta-analysis in order to assess the efficacy and safety of VPZ vs PPI for H. pylori eradication. MATERIALS AND METHODS: The PubMed, EMBASE, and Cochrane Library databases were searched up to July 10, 2017, for relevant randomized controlled trials (RCTs) and nonrandomized clinical studies (NRCTs)...
September 8, 2017: Helicobacter
https://www.readbyqxmd.com/read/28851031/immunologic-properties-and-therapeutic-efficacy-of-a-multivalent-epitope-based-vaccine-against-four-helicobacter-pylori-adhesins-urease-lpp20-hpaa-and-cagl-in-mongolian-gerbils
#6
Le Guo, Runting Yin, Guangxian Xu, Xiaojuan Gong, Zisong Chang, Dantong Hong, Hongpeng Liu, Shuqin Ding, Xuebo Han, Yuan Li, Feng Tang, Kunmei Liu
BACKGROUND: Therapeutic vaccination is a desirable alternative for controlling Helicobacter pylori (H. pylori) infection. Attachment to the gastric mucosa is the first step in establishing bacterial colonization, and adhesins, which are on the surface of H. pylori, play a pivotal role in binding to human gastric mucosa. MATERIALS AND METHODS: In the present study, we constructed a multivalent epitope-based vaccine named CFAdE with seven carefully selected antigenic fragments from four H...
August 29, 2017: Helicobacter
https://www.readbyqxmd.com/read/28840971/specific-mutations-of-penicillin-binding-protein-1a-in-77-clinically-acquired-amoxicillin-resistant-helicobacter-pylori-strains-in-comparison-with-77-amoxicillin-susceptible-strains
#7
Yong Hwan Kwon, Ji Yeon Kim, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Sun Min Lee, Jin-Wook Kim, Jung Mogg Kim, Jong Youn Park, Dong Ho Lee
BACKGROUND: Amoxicillin (Amx) is one of the most important antibiotics for eradication of Helicobacter pylori (H. pylori). Main determinants of genetically stable Amx resistance are mutations in the C-terminus of penicillin-binding protein 1A (pbp1A). However, contribution of individual mutation remains unclear. METHODS: 77 Amx-resistant (Amx(R) ) and 77 Amx-susceptible (Amx(S) ) H. pylori strains were isolated from gastric tissues, and DNA sequencing was performed to compare C-terminus sequences of pbp1A gene between Amx(R) and Amx(S) strains...
August 25, 2017: Helicobacter
https://www.readbyqxmd.com/read/28834011/protective-efficacy-of-a-hydroxy-fatty-acid-against-gastric-helicobacter-infections
#8
Hidenori Matsui, Tetsufumi Takahashi, Somay Y Murayama, Marina Kawaguchi, Koichi Matsuo, Masahiko Nakamura
BACKGROUND: We have previously revealed that omega-3 polyunsaturated fatty acids can prevent Helicobacter pylori infection by blocking the futalosine pathway, an alternative route for menaquinone (MK) biosynthesis. MATERIALS AND METHODS: 1, Different H. pylori strains were grown in liquid media supplemented with linoleic acid, an omega-6 fatty acid, or its 10-hydroxy derivative, 10-hydroxy-cis-12-octadecenoic acid (HYA), in the presence or absence of MK. The bacterial numbers in the media were estimated by plating; 2, C57BL/6NCrl mice received drinking water supplemented with different fatty acids starting from 1 week before infection with H...
August 22, 2017: Helicobacter
https://www.readbyqxmd.com/read/28833925/efficacy-of-three-in-one-capsule-bismuth-quadruple-therapy-for-helicobacter-pylori-eradication-in-clinical-practice-in-a-multinational-patient-population
#9
Stephan Miehlke, Dorothea Frederking, Thomas Günther, Erik Glocker, Bianca Eisele, Viola Andresen, Sören Schröder, Andrea Morgner
BACKGROUND: Bismuth quadruple therapy (BQT) has been proven superior to standard triple therapy for Helicobacter pylori eradication in randomized clinical trials; however, little is known about the efficacy of BQT in daily routine practice. METHODS: In a single-center cohort study, we analyzed consecutive H. pylori-positive patients in whom three-in-one capsule BQT (Pylera(®) + omeprazole) has been prescribed. All patients were instructed in a standardized fashion, and a prospective follow-up was planned...
August 22, 2017: Helicobacter
https://www.readbyqxmd.com/read/28833968/endoscopic-characteristics-of-infection-associated-peptic-ulcers
#10
Seong-Hyung Choi, Dong-Min Kim, Jun Lee, Na Ra Yun
BACKGROUND: Aside from Helicobacter pylori, another cause for the development or worsening of gastrointestinal ulcers is scrub typhus, an acute febrile disease caused by Orientia tsutsugamushi. We aimed to compare the endoscopic characteristics of peptic ulcers caused by these infectious agents. METHODS: This retrospective case-control study involved patients who underwent upper gastrointestinal endoscopy at Chosun University Hospital in Korea. We compared endoscopic features and demographic characteristics between patients with H...
August 18, 2017: Helicobacter
https://www.readbyqxmd.com/read/28805287/nongenetically-modified-lactococcus-lactis-adjuvanted-vaccination-enhanced-innate-immunity-against-helicobacter-pylori
#11
Wei Liu, Zhoulin Tan, Hai Liu, Zhiqin Zeng, Shuanghui Luo, Huimin Yang, Lufeng Zheng, Tao Xi, Yingying Xing
BACKGROUND: Gram-positive enhancer matrix particles (GEM) produced by Lactococcus lactis can enhance vaccine-induced immune response. However, the mechanism under which this adjuvant mounts the efficacy of orally administered vaccines remains unexplored. MATERIALS AND METHODS: We used a prophylactic mice model to investigate the mechanism of GEM-adjuvanted vaccination. Helicobacter pylori urease-specific antibody response was monitored and detected in murine serum by ELISA...
August 14, 2017: Helicobacter
https://www.readbyqxmd.com/read/28799687/upfront-immunohistochemistry-improves-specificity-of-helicobacter-pylori-diagnosis-a-french-pathology-laboratory-point-of-view
#12
Florent Ginestet, Briac Guibourg, Laurent Doucet, Jérémie Théreaux, Michel Robaszkiewicz, Pascale Marcorelles, Arnaud Uguen
BACKGROUND: There is no consensus about the histopathologic methods to detect Helicobacter pylori in gastric biopsies to date. We aimed to question about the value of upfront anti-H. pylori immunohistochemistry in this field. MATERIAL AND METHODS: We led a retrospective study about the rate of H. pylori-positive gastric biopsies before and after the implementation of upfront immunohistochemistry, the inter-rater and intermethods agreements in H. pylori identification about Hematoxylin-Eosin Saffron (HES), Giemsa, and immunohistochemistry stains and the histopathologic features associated with low amounts of H...
August 11, 2017: Helicobacter
https://www.readbyqxmd.com/read/28799681/genomic-and-clinical-evidence-uncovers-the-enterohepatic-species-helicobacter-valdiviensis-as-a-potential-human-intestinal-pathogen
#13
Pablo Fresia, Ronald Jara, Rafael Sierra, Ignacio Ferrés, Gonzalo Greif, Gregorio Iraola, Luis Collado
BACKGROUND: Helicobacter valdiviensis is a recently described enterohepatic species isolated from wild bird's fecal samples. Currently, its pathogenic potential and clinical significance are unknown mainly due to the lack of whole-genome sequences to compare with other helicobacters and the absence of specific screenings to determine its prevalence in humans. MATERIALS AND METHODS: The species type strain (WBE14(T) ) was whole-genome-sequenced, and comparative analyses were carried out including the genomes from other Helicobacter species to determine the exact phylogenetic position of H...
August 11, 2017: Helicobacter
https://www.readbyqxmd.com/read/28771894/effect-on-helicobacter-pylori-eradication-therapy-against-gastric-cancer-in-japan
#14
Momoko Tsuda, Masahiro Asaka, Mototsugu Kato, Rumiko Matsushima, Kenji Fujimori, Kozo Akino, Shogo Kikuchi, Yingsong Lin, Naoya Sakamoto
BACKGROUND: In Japan, there have been approximately 50 000 deaths from gastric cancer annually for over 40 years with little variation. It has been reported that most gastric cancers in Japan are caused by Helicobacter pylori infection. H. pylori eradication therapy was approved for patients with chronic gastritis by the Japanese national health insurance scheme in February 2013 for patients with an endoscopic diagnosis of chronic gastritis is positive for H. pylori. We examined the effect on gastric cancer death rate 4 years after expansion of health insurance coverage...
August 3, 2017: Helicobacter
https://www.readbyqxmd.com/read/28771880/limited-effectiveness-with-a-10-day-bismuth-containing-quadruple-therapy-pylera-%C3%A2-in-third-line-recue-treatment-for-helicobacter-pylori-infection-a-real-life-multicenter-study
#15
Enrique Rodríguez de Santiago, Carlos Martín de Argila de Prados, Hector Miguel Marcos Prieto, Miguel Ãngel Jorge Turrión, Eva Barreiro Alonso, Alvaro Flores de Miguel, Cristobal de la Coba Ortiz, Carlos Rodríguez Escaja, Gustavo Pérez Álvarez, Carlos Ferre Aracil, Lara Aguilera Castro, Ana García García de Paredes, Antonio Rodríguez Pérez, Agustin Albillos Martínez
BACKGROUND: Helicobacter pylori antibiotic resistance is an increasing problem worldwide. Pylera(®) may be an option as salvage therapy. AIM: To assess the effectiveness, safety, and tolerance of Pylera(®) as a third-line in clinical practice. MATERIALS AND METHODS: This was a multicenter, observational, prospective database study in four Spanish hospitals. Consecutive H. pylori-infected individuals treated with Pylera(®) and a proton-pump inhibitor (PPI) were invited to participate if they had failed to respond to PPI-clarithromycin-amoxicillin as first-line and to levofloxacin-amoxicillin-PPI as second-line therapy...
August 3, 2017: Helicobacter
https://www.readbyqxmd.com/read/28737284/antibody-reactivity-against-helicobacter-pylori-proteins-in-a-sample-of-the-spanish-adult-population-in-2008-2013
#16
Nerea Fernández-de-Larrea, Angelika Michel, Beatriz Romero, Julia Butt, Michael Pawlita, Beatriz Pérez-Gómez, Gemma Castaño-Vinyals, Victor Moreno, Vicente Martín, Pilar Amiano, Jesús Castilla, Guillermo Fernández-Tardón, Trinidad Dierssen-Sotos, Juan Clofent, Juan Alguacil, José María Huerta, José Juan Jiménez-Moleón, Aurelio Barricarte, Amaia Molinuevo, Tania Fernández-Villa, Delphine Casabonne, Ángeles Sierra, Manolis Kogevinas, Silvia de Sanjosé, Marina Pollán, Rosa Del Campo, Tim Waterboer, Nuria Aragonés
BACKGROUND: Differences in Helicobacter pylori protein expression have been related to the risk of severe gastric diseases. In Spain, a marked geographic pattern in gastric cancer mortality has long been reported. OBJECTIVE: To characterize antibody reactivity patterns against 16 H. pylori proteins, by age, sex, and region of birth, in a large sample of the Spanish adult population. MATERIALS AND METHODS: Antibody reactivity was quantified by H...
July 24, 2017: Helicobacter
https://www.readbyqxmd.com/read/28891140/other-helicobacters-gastric-and-gut-microbiota
#17
REVIEW
Christelle Péré-Védrenne, Bram Flahou, Mun Fai Loke, Armelle Ménard, Jamuna Vadivelu
The current article is a review of the most important and relevant literature published in 2016 and early 2017 on non-Helicobacter pylori Helicobacter infections in humans and animals, as well as interactions between H. pylori and the microbiota of the stomach and other organs. Some putative new Helicobacter species were identified in sea otters, wild boars, dogs, and mice. Many cases of Helicobacter fennelliae and Helicobacter cinaedi infection have been reported in humans, mostly in immunocompromised patients...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28891139/helicobacter-pylori-infection-in-children
#18
REVIEW
Nicolas Kalach, Patrick Bontems, Josette Raymond
Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies. The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28891138/epidemiology-of-helicobacter-pylori-infection
#19
REVIEW
Christophe Burucoa, Anthony Axon
The study of Helicobacter pylori genetic variability brought us interesting data on the history of mankind. Based on multilocus sequence typing and more recently on whole-genome sequencing, paleomicrobiology still attracts the attention of global researchers in relation to its ancestor roots and coexistence with humans. Three studies determining the prevalence of virulence factors illustrates the controversial results obtained since 30 years by studies trying to associate prevalence of different virulence markers and clinical outcomes of H...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28891137/treatment-of-helicobacter-pylori-infection-2017
#20
REVIEW
Anthony O'Connor, Dominique Lamarque, Javier P Gisbert, Colm O'Morain
This review summarizes important studies regarding Helicobacter pylori therapy published from April 2016 to April 2017. The main themes that emerge involve studies assessing the efficacy of bismuth and nonbismuth quadruple regimens. While in recent years, much of the emphasis on the use of bismuth has focussed on its utility in a second-line setting, an increasing number of studies this year have shown excellent efficacy in first-line therapy. The efficacy of bismuth as a second-line after sequential and concomitant therapy was particularly noteworthy...
September 2017: Helicobacter
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