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Helicobacter

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https://www.readbyqxmd.com/read/29345408/the-effect-of-eradication-of-helicobacter-pylori-on-gastric-cancer-prevention-in-healthy-asymptomatic-populations
#1
Suh Eun Bae, Kee Don Choi, Jaewon Choe, Seon Ok Kim, Hee Kyong Na, Ji Young Choi, Ji Yong Ahn, Kee Wook Jung, JeongHoon Lee, Do Hoon Kim, Hye-Sook Chang, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
BACKGROUND: Although many epidemiologic studies have evaluated the effect of Helicobacter pylori eradication on gastric cancer, the effect is still uncertain in general populations. We evaluated whether H. pylori eradication would affect the incidence of gastric cancer in healthy asymptomatic populations. MATERIALS AND METHODS: We performed a retrospective cohort study in 38 984 asymptomatic individuals, who underwent health screening examinations more than twice between 2005 and 2016...
January 18, 2018: Helicobacter
https://www.readbyqxmd.com/read/29345406/helicobacter-pylori-infection-and-occurrence-of-celiac-disease-in-subjects-hla-dq2-dq8-positive-a-prospective-study
#2
Maria P Dore, Roberta Salis, Maria F Loria, Vincenzo Villanacci, Gabrio Bassotti, Giovanni M Pes
BACKGROUND: Celiac disease (CD) occurs in subjects positive for HLA-DQ2 and/or DQ8 gene loci at any age following ingestion of gluten-containing food. An increased permeability of the mucosa allows interactions between gliadin macromolecules and genetic factors. It has been observed that Helicobacter pylori has the ability to modulate the integrity of the duodenal epithelium. We aimed to determine whether H. pylori infection may enhance the occurrence of CD in genetically susceptible subjects...
January 18, 2018: Helicobacter
https://www.readbyqxmd.com/read/29345022/seroprevalence-of-helicobacter-pylori-in-korea-a-multicenter-nationwide-study-conducted-in-2015-and-2016
#3
Jeong Hoon Lee, Kee Don Choi, Hwoon-Yong Jung, Gwang Ho Baik, Jong Kyu Park, Sung Soo Kim, Byung-Wook Kim, Su Jin Hong, Hyun Lim, Cheol Min Shin, Si Hyung Lee, Seong Woo Jeon, Ji Hyun Kim, Cheol Woong Choi, Hye-Kyung Jung, Jie-Hyun Kim, Suck Chei Choi, Jin Woong Cho, Wan Sik Lee, Soo-Young Na, Jae Kyu Sung, Kyung Ho Song, Jun-Won Chung, Sung-Cheol Yun
BACKGROUND: The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables. METHODS: We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju)...
January 18, 2018: Helicobacter
https://www.readbyqxmd.com/read/29316052/an-assessment-of-drinking-water-contamination-with-helicobacter-pylori-in-lima-peru
#4
Kevin F Boehnke, Rebecca K Brewster, Brisa N Sánchez, Manuel Valdivieso, Alejandro Bussalleu, Magaly Guevara, Claudia Gonzales Saenz, Soledad Osorio Alva, Elena Gil, Chuanwu Xi
BACKGROUND: Helicobacter pylori is a gut bacterium that is the primary cause of gastric cancer. H. pylori infection has been consistently associated with lack of access to sanitation and clean drinking water. In this study, we conducted time-series sampling of drinking water in Lima, Peru, to examine trends of H. pylori contamination and other water characteristics. MATERIALS AND METHODS: Drinking water samples were collected from a single faucet in Lima's Lince district 5 days per week from June 2015 to May 2016, and pH, temperature, free available chlorine, and conductivity were measured...
January 8, 2018: Helicobacter
https://www.readbyqxmd.com/read/29315985/comparative-analysis-of-the-hom-family-of-outer-membrane-proteins-in-isolates-from-two-geographically-distinct-regions-the-united-states-and-south-korea
#5
Stephanie L Servetas, Aeryun Kim, Hanfu Su, Jeong-Heon Cha, D Scott Merrell
BACKGROUND: Helicobacter pylori encodes numerous outer membrane proteins (OMPs), but only a few have been characterized in depth. Deletion, duplication, and allelic variation of many of the H. pylori OMPs have been reported, which suggests that these proteins may play key roles in host adaptation. Herein, we characterize the variation observed within the Hom family of OMPs in H. pylori obtained from two geographically distinct populations. MATERIALS AND METHODS: PCR genotyping of the hom genes was carried out using clinical isolates from South Korea and the United States...
January 5, 2018: Helicobacter
https://www.readbyqxmd.com/read/29315971/levels-of-malondialdehyde-in-the-gastric-juice-its-association-with-helicobacter-pylori-infection-and-stomach-diseases
#6
Yao-Kuang Wang, Wei-Chih Chiang, Fu-Chen Kuo, Meng-Chieh Wu, Hsiang-Yao Shih, Sophie S W Wang, Chung-Jung Liu, Yen-Hsu Chen, Deng-Chyang Wu, Wei-Wen Su, Yeou-Lih Huang
BACKGROUND: Helicobacter pylori (H. pylori) infection causes elevation of lipid peroxidation product malondialdehyde (MDA) and this association may be due to the bacterium causing reactive oxygen species-mediated damage to DNA in the gastric epithelium. The aim of this study was to investigate the gastric juice MDA levels in relation to H. pylori infection and associated gastric diseases. METHODS: Gastric juice samples were obtained from 117 patients undergoing endoscopy, and gastric juice MDA levels were determined by high-performance liquid chromatography (HPLC) system...
January 5, 2018: Helicobacter
https://www.readbyqxmd.com/read/29271026/vonoprazan-vs-proton-pump-inhibitor-based-first-line-7-day-triple-therapy-for-clarithromycin-susceptible-helicobacter-pylori-a-multicenter-prospective-randomized-trial
#7
Soichiro Sue, Marina Ogushi, Isao Arima, Hirofumi Kuwashima, Satoshi Nakao, Makoto Naito, Kazuo Komatsu, Hiroaki Kaneko, Toshihide Tamura, Tomohiko Sasaki, Masaaki Kondo, Wataru Shibata, Shin Maeda
BACKGROUND: The eradication rate of vonoprazan-based first-line triple therapy (combined with clarithromycin and amoxicillin) (V-AC) was reported to be 97.6% in patients with clarithromycin (CAM)-susceptible Helicobacter pylori in a phase III study, whereas our real-world, prospective, multicenter cohort study yielded an eradication rate <90%. OBJECTIVE: To validate the eradication rate of V-AC using CAM-susceptible testing in a multicenter, prospective, randomized trial...
December 21, 2017: Helicobacter
https://www.readbyqxmd.com/read/29266548/helicobacter-pylori-infection-of-the-gallbladder-and-the-risk-of-chronic-cholecystitis-and-cholelithiasis-a-systematic-review-and-meta-analysis
#8
Li Cen, Jiaqi Pan, Boyan Zhou, Chaohui Yu, Youming Li, Weixing Chen, Zhe Shen
BACKGROUND: Helicobacter pylori is coexisted with various diseases, including chronic gastritis, ulcer, and gastric cancer. Besides, chronic cholecystitis and cholelithiasis are extremely widespread over the world, which are considered as high health-care cost burdens of digestive diseases. Epidemiologic evidence on Helicobacter pylori infection in gallbladder increasing the risk of biliary diseases has been contradictory. AIM: Conduct a meta-analysis of overall studies and investigate an association between Helicobacter pylori infection of the gallbladder with chronic cholecystitis/cholelithiasis...
December 20, 2017: Helicobacter
https://www.readbyqxmd.com/read/29235197/superoxide-dismutase-from-helicobacter-pylori-suppresses-the-production-of-pro-inflammatory-cytokines-during-in-vivo-infection
#9
Andrew Stent, Alison L Every, Yok T Chionh, Garrett Z Ng, Philip Sutton
BACKGROUND: Helicobacter pylori has undergone considerable adaptation to allow chronic persistence within the gastric environment. While H. pylori-associated diseases are driven by an excessive inflammation, severe gastritis is detrimental to colonization by this pathogen. Hence, H. pylori has developed strategies to minimize the severity of gastritis it triggers in its host. Superoxide dismutase (SOD) is well known for its role in protecting against oxidative attack; less recognized is its ability to inhibit immunity, shown for SOD from mammalian sources and those of some bacterial species...
December 13, 2017: Helicobacter
https://www.readbyqxmd.com/read/29218758/first-evidence-of-bacterial-translocation-from-the-intestinal-tract-as-a-route-of-helicobacter-cinaedi-bacteremia
#10
Hideki Araoka, Masaru Baba, Chikako Okada, Muneyoshi Kimura, Tomoaki Sato, Yutaka Yatomi, Kyoji Moriya, Akiko Yoneyama
BACKGROUND: The route of Helicobacter cinaedi bacteremia has not yet been clarified. Although bacterial translocation from the intestinal tract into the circulation has been suggested, it has not been demonstrated thus far. The objective of this study was to investigate the port of entry of this bacterium. MATERIAL AND METHODS: We conducted a retrospective study on patients with H. cinaedi bacteremia between March 2009 and May 2013. Records of patients in whom H...
December 8, 2017: Helicobacter
https://www.readbyqxmd.com/read/29210527/seroprevalence-of-helicobacter-pylori-in-hispanics-living-in-puerto-rico-a-population-based-study
#11
María González-Pons, Marievelisse Soto-Salgado, Javier Sevilla, Juan M Márquez-Lespier, Douglas Morgan, Cynthia M Pérez, Marcia Cruz-Correa
BACKGROUND: Helicobacter pylori is an important etiologic factor for peptic ulcers and gastric cancer, one of the top ten leading causes of cancer death in Puerto Rico. However, the prevalence of H. pylori infections in this population was previously unknown. The aim of this study was to examine the seroprevalence of H. pylori and its associated risk factors in Puerto Rico. MATERIALS AND METHODS: A cross-sectional study was designed using an existing population-based biorepository...
December 6, 2017: Helicobacter
https://www.readbyqxmd.com/read/29181894/impact-of-helicobacter-pylori-on-alzheimer-s-disease-what-do-we-know-so-far
#12
REVIEW
Michael Doulberis, Georgios Kotronis, Robert Thomann, Stergios A Polyzos, Marina Boziki, Dimitra Gialamprinou, Georgia Deretzi, Panagiotis Katsinelos, Jannis Kountouras
BACKGROUND: Helicobacter pylori has changed radically gastroenterologic world, offering a new concept in patients' management. Over time, more medical data gave rise to diverse distant, extragastric manifestations and interactions of the "new" discovered bacterium. Special interest appeared within the field of neurodegenerative diseases and particularly Alzheimer's disease, as the latter and Helicobacter pylori infection are associated with a large public health burden and Alzheimer's disease ranks as the leading cause of disability...
November 27, 2017: Helicobacter
https://www.readbyqxmd.com/read/29181860/detection-of-helicobacter-pylori-in-stool-samples-of-young-children-using-real-time-polymerase-chain-reaction
#13
Gany Beer-Davidson, Musa Hindiyeh, Khitam Muhsen
BACKGROUND: The aims of this study were to develop and validate a multiplex real-time polymerase chain reaction (q-PCR) assay of Helicobacter pylori in stool samples of healthy children. Additionally, we determined the prevalence of clarithromycin resistance and cagA gene in H. pylori-positive samples. MATERIALS AND METHODS: Archived stool samples from 188 children aged 6-9 years and 272 samples of 92 infants aged 2-18 months were tested for H. pylori antigens using enzyme immunoassay (EIA)...
November 27, 2017: Helicobacter
https://www.readbyqxmd.com/read/29178562/macrolide-use-in-the-previous-years-is-associated-with-failure-to-eradicate-helicobacter-pylori-with-clarithromycin-containing-regimens
#14
Pablo Muñoz-Gómez, Junior Alexander Jordán-Castro, María Abanades-Tercero, José Javier Blanco-González, Eva María Andrés Esteban, Julio Valle-Muñoz
BACKGROUND: There is some evidence that prior use of macrolide antibiotics is a useful predictor of the likelihood of standard triple therapy failure in Helicobacter pylori eradication. In this study, we have evaluated whether previous intake of macrolides correlates with failure to eradicate H. pylori using two different first-line clarithromycin-containing regimens. MATERIALS AND METHODS: Retrospective study of 212 patients with H. pylori infection treated with one of two first-line clarithromycin-containing regimens: 108 patients treated with triple therapy for 10 days and 104 patients treated with concomitant therapy for 10 days...
November 26, 2017: Helicobacter
https://www.readbyqxmd.com/read/29178407/a-meta-analysis-of-the-association-between-helicobacter-pylori-h-%C3%A2-pylori-infection-and-hyperemesis-gravidarum
#15
Qin Xiang Ng, Nandini Venkatanarayanan, Michelle Lee Zhi Qing De Deyn, Collin Yih Xian Ho, Yin Mo, Wee-Song Yeo
BACKGROUND: Hyperemesis gravidarum remains a common, distressing, and significant yet poorly understood disorder during pregnancy. The association between maternal Helicobacter pylori (H. pylori) infection and hyperemesis gravidarum has been increasingly recognized and investigated. This study thus aimed to provide an updated review and meta-analysis of the topic. METHODS: Using the search terms (H. pyloriOR Helicobacter ORHelicobacter pyloriOR infection) AND (pregnancy OR emesis OR hyperemesis gravidarum OR nausea OR vomiting), a preliminary search on the PubMed, Ovid, Web of Science, Google Scholar, and WanFang database yielded 372 papers published in English between January 1st, 1960 and June 1st, 2017...
November 26, 2017: Helicobacter
https://www.readbyqxmd.com/read/29168600/molecular-characterization-of-helicobacter-pylori-resistance-to-rifamycins
#16
Constantin Hays, Christophe Burucoa, Philippe Lehours, Cong Tri Tran, Anaïs Leleu, Josette Raymond
INTRODUCTION: Antibiotic resistance is a major contributing factor in treatment failure of Helicobacter pylori eradication. Rifabutin (RB) is a rescue treatment and rifampicin (RP) is used to screen RB resistance in vitro. The aim of this study was to evaluate the rate of rifamycins resistance and to determine the mutations in the rpoB gene conferring resistance to discuss the current break point. METHODS: Antimicrobial susceptibility to RP was first determined by E-test for 1015 H...
November 23, 2017: Helicobacter
https://www.readbyqxmd.com/read/29110387/cholesterol-%C3%AE-glucosyltransferase-gene-is-present-in-most-helicobacter-species-including-gastric-non-helicobacter-pylori-helicobacters-obtained-from-japanese-patients
#17
Masatomo Kawakubo, Kazuki Horiuchi, Takehisa Matsumoto, Jun Nakayama, Taiji Akamatsu, Tsutomu Katsuyama, Hiroyoshi Ota, Junji Sagara
BACKGROUND: Non-Helicobacter pylori helicobacters (NHPHs) besides H. pylori infect human stomachs and cause chronic gastritis and mucosa-associated lymphoid tissue lymphoma. Cholesteryl-α-glucosides have been identified as unique glycolipids present in H. pylori and some Helicobacter species. Cholesterol-α-glucosyltransferase (αCgT), a key enzyme for the biosynthesis of cholesteryl-α-glucosides, plays crucial roles in the pathogenicity of H. pylori. Therefore, it is important to examine αCgTs of NHPHs...
November 7, 2017: Helicobacter
https://www.readbyqxmd.com/read/29094477/rescue-therapy-with-bismuth-quadruple-regimen-in-patients-with-helicobacter-pylori-resistant-strains
#18
Giulia Fiorini, Ilaria Maria Saracino, Angelo Zullo, Luigi Gatta, Matteo Pavoni, Dino Vaira
BACKGROUND: Bismuth quadruple therapy (BQT) is the recommended rescue therapy for Helicobacter pylori (H. pylori) infection. This study aimed to assess the efficacy and safety of a 10-day BQT regimen in patients who failed previous therapies and were infected with multiresistant H. pylori strains MATERIALS AND METHODS: Helicobacter pylori-infected patients underwent endoscopy, culture, and susceptibility test for clarithromycin, metronidazole, and levofloxacin. Treatment with three-in-one capsule (Pylera®) four times daily and esomeprazole 20 mg twice daily for 10 days was administered...
December 2017: Helicobacter
https://www.readbyqxmd.com/read/28940945/effect-of-biopsy-site-on-detection-of-gastric-cancer-high-risk-groups-by-olga-and-olgim-stages
#19
Young-Il Kim, Myeong-Cherl Kook, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Jungnam Joo, Il Ju Choi
BACKGROUND/AIMS: The operative link for gastritis assessment (OLGA) and operative link on gastric intestinal metaplasia assessment (OLGIM) staging systems are recommended to assess the severity of gastritis, but the optimal biopsy sites have not been clearly defined. We aimed to investigate whether the scoring of the OLGA and OLGIM stages was affected by the use of different biopsy sites. METHODS: Between 2014 and 2015, to determine OLGA and OLGIM stages, seven biopsy samples were obtained from the antrum (lesser and greater curvatures [LG] of the antrum and lesser curvature of the angle) and corpus (LG and anterior and posterior walls [AP]) in 247 patients diagnosed with gastritis, gastric adenoma, or adenocarcinoma...
December 2017: Helicobacter
https://www.readbyqxmd.com/read/29058343/genotype%C3%A2-helicodr-test-in-comparison-with-histology-and-culture-for-helicobacter-pylori-detection-and-identification-of-resistance-mutations-to-clarithromycin-and-fluoroquinolones
#20
Nina Pastukh, Dana Binyamin, Avi On, Maya Paritsky, Avi Peretz
BACKGROUND: There are several methods for Helicobacter pylori infection diagnosis. AIM: The efficacies of three methods for H. pylori identification directly from a biopsy were compared: histology, culture, and molecular GenoType® HelicoDR test. MATERIALS & METHODS: Eighty-five triplicates of stomach antrum biopsies were obtained during gastroscopy procedures for culture, histology, and molecular assay. In addition, we performed molecular identification of genes encoding resistance to clarithromycin and fluoroquinolones...
October 23, 2017: Helicobacter
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