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Helicobacter

journal
https://www.readbyqxmd.com/read/28643393/prevalence-and-dynamics-of-helicobacter-pylori-infection-during-childhood
#1
REVIEW
Beatriz Zabala Torrres, Yalda Lucero, Anne J Lagomarcino, Andrea Orellana-Manzano, Sergio George, Juan P Torres, Miguel O'Ryan
INTRODUCTION: Long-term persistent Helicobacter pylori infection has been associated with ulceropeptic disease and gastric cancer. Although H. pylori is predominantly acquired early in life, a clear understanding of infection dynamics during childhood has been obfuscated by the diversity of populations evaluated, study designs, and methods used. AIM: Update understanding of true prevalence of H. pylori infection during childhood, based on a critical analysis of the literature published in the past 5 years...
June 23, 2017: Helicobacter
https://www.readbyqxmd.com/read/28598012/association-of-helicobacter-pylori-infection-with-parkinson-s-diseases-a-meta-analysis
#2
REVIEW
Xiaoli Shen, Huazhen Yang, Yili Wu, Dongfeng Zhang, Hong Jiang
BACKGROUND: The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease. METHODS: A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies...
June 9, 2017: Helicobacter
https://www.readbyqxmd.com/read/28557128/detection-of-gastric-atrophy-by-circulating-pepsinogens-a-comparison-of-three-assays
#3
Marcis Leja, Maria C Camargo, Inese Polaka, Sergejs Isajevs, Inta Liepniece-Karele, Dainius Janciauskas, Dace Rudzite, Ilze Kikuste, Aigars Vanags, Ilona Kojalo, Valdis Folkmanis, Arnis Kirsners, Ivars Tolmanis, Charles S Rabkin
BACKGROUND: Circulating levels of pepsinogens have been used in high gastric cancer-risk Asian and European populations to triage endoscopic evaluation for more severe pathology. There are different analytic methods with uncertain correlations. We therefore compared diagnostic performance of three commonly used pepsinogen assays to detect histologically confirmed gastric atrophy. METHODS: We tested plasma samples from adult patients with (n=50) and without (n=755) moderate or severe gastric corpus atrophy, as determined histologically by consensus of three expert pathologists...
May 29, 2017: Helicobacter
https://www.readbyqxmd.com/read/28544222/usefulness-of-detection-of-clarithromycin-resistant-helicobacter-pylori-from-fecal-specimens-for-young-adults-treated-with-eradication-therapy
#4
Takako Osaki, Katsuhiro Mabe, Cynthia Zaman, Hideo Yonezawa, Masumi Okuda, Kenji Amagai, Shinji Fujieda, Mitsuhide Goto, Wataru Shibata, Mototsugu Kato, Shigeru Kamiya
BACKGROUND: To prevent Helicobacter pylori infection in the younger generation, it is necessary to investigate the prevalence of antibiotic-resistant H. pylori. OBJECTIVE: The aim of this study was to evaluate the method of PCR-based sequencing to detect clarithromycin (CAM) resistance-associated mutations using fecal samples as a noninvasive method. METHODS: DNA extracted from fecal specimens and isolates from gastric biopsy specimens were collected from patients with H...
May 22, 2017: Helicobacter
https://www.readbyqxmd.com/read/28544172/phylogeographic-agreement-between-prophage-and-bacterial-housekeeping-genes-in-helicobacter-pylori-strains-from-the-gambia
#5
LETTER
Ousman Secka, Filipa F Vale, Alice Buissonnière, Julian E Thomas, Francis Mégraud, Philippe Lehours
No abstract text is available yet for this article.
May 22, 2017: Helicobacter
https://www.readbyqxmd.com/read/28524341/randomized-controlled-study-of-a-novel-triple-nitazoxanide-ntz-containing-therapeutic-regimen-versus-the-traditional-regimen-for-eradication-of-helicobacter-pylori-infection
#6
Mona Ah Shehata, Raghda Talaat, Samah Soliman, Huda Elmesseri, Shaimaa Soliman, Sherief Abd-Elsalam
BACKGROUND: Helicobacter pylori infection has become more and more resistant to conventional first-line treatment regimens. So, there is a considerable interest in evaluating new antibiotic combinations and regimens. Nitazoxanide is an anti-infective drug with demonstrated activity against protozoa and anaerobic bacteria including H. pylori. This work is designed to evaluate the efficacy and safety of a unique triple nitazoxanide-containing regimen as a treatment regimen in Egyptian patients with H...
May 19, 2017: Helicobacter
https://www.readbyqxmd.com/read/28464347/optimization-strategies-aimed-to-increase-the-efficacy-of-h-%C3%A2-pylori-eradication-therapies
#7
REVIEW
Javier P Gisbert, Adrian G McNicholl
BACKGROUND: As with any other infectious disease, we should aim for treatments offering ≥90% Helicobacter pylori eradication rates in clinical practice. AIM: To summarize optimization strategies aimed to increase the efficacy of H. pylori eradication therapies. METHODS: A systematic bibliographic search (in PubMed up to August 2016) was designed to identify studies investigating optimization strategies aimed to increase the efficacy of H...
May 2, 2017: Helicobacter
https://www.readbyqxmd.com/read/28436616/reduced-infectivity-of-waterborne-viable-but-nonculturable-helicobacter-pylori-strain-ss1-in-mice
#8
Kevin F Boehnke, Kathryn A Eaton, Clinton Fontaine, Rebecca Brewster, Jianfeng Wu, Joseph N S Eisenberg, Manuel Valdivieso, Laurence H Baker, Chuanwu Xi
BACKGROUND: Helicobacter pylori infection has been consistently associated with lack of access to clean water and proper sanitation, but no studies have demonstrated that the transmission of viable but nonculturable (VBNC) H. pylori can occur from drinking contaminated water. In this study, we used a laboratory mouse model to test whether waterborne VBNCH. pylori could cause gastric infection. MATERIALS AND METHODS: We performed five mouse experiments to assess the infectivity of VBNCH...
April 24, 2017: Helicobacter
https://www.readbyqxmd.com/read/28436598/the-expression-of-helicobacter-pylori-tfs-plasticity-zone-cluster-is-regulated-by-ph-and-adherence-and-its-composition-is-associated-with-differential-gastric-il-8-secretion
#9
Bruno Silva, Alexandra Nunes, Filipa F Vale, Raquel Rocha, João Paulo Gomes, Ricardo Dias, Mónica Oleastro
BACKGROUND: Helicobacter pylori virulence is associated with different clinical outcomes. The existence of an intact dupA gene from tfs4b cluster has been suggested as a predictor for duodenal ulcer development. However, the role of tfs plasticity zone clusters in the development of ulcers remains unclear. We studied several H. pylori strains to characterize the gene arrangement of tfs3 and tfs4 clusters and their impact in the inflammatory response by infected gastric cells. METHODS: The genome of 14 H...
April 24, 2017: Helicobacter
https://www.readbyqxmd.com/read/28425141/efficacy-of-helicobacter-pylori-eradication-therapies-in-korea-a-systematic-review-and-network-meta-analysis
#10
REVIEW
Yoon Suk Jung, Chan Hyuk Park, Jung Ho Park, Eunwoo Nam, Hang Lak Lee
BACKGROUND: The efficacy of Helicobacter pylori eradication regimens may depend on the country where the studies were performed because of the difference in antibiotic resistance. We aimed to analyze the efficacy of H. pylori eradication regimens in Korea where clarithromycin resistance rate is high. METHODS: We searched for all relevant randomized controlled trials published until November 2016 that investigated the efficacy of H. pylori eradication therapies in Korea...
April 19, 2017: Helicobacter
https://www.readbyqxmd.com/read/28402048/sensitivity-of-helicobacter-pylori-detection-by-giemsa-staining-is-poor-in-comparison-with-immunohistochemistry-and-fluorescent-in-situ-hybridization-and-strongly-depends-on-inflammatory-activity
#11
Éva Kocsmár, Ildikó Szirtes, Zsófia Kramer, Attila Szijártó, László Bene, György Miklós Buzás, István Kenessey, Peter Bronsert, Agnes Csanadi, Lisa Lutz, Martin Werner, Ulrich Friedrich Wellner, András Kiss, Zsuzsa Schaff, Gábor Lotz
BACKGROUND: Conventional stainings (including H&E and special stains like Giemsa) are the most widely applied histopathologic detection methods of Helicobacter pylori (HP). MATERIALS AND METHODS: We aimed to compare the diagnostic performance of Giemsa staining with immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) on a monocentric cohort of 2896 gastric biopsies and relate results to histologic alterations in order to find such histopathologic subgroups in which these methods underperform...
April 12, 2017: Helicobacter
https://www.readbyqxmd.com/read/28402047/survival-of-helicobacter-pylori-in-gastric-acidic-territory
#12
REVIEW
Shamshul Ansari, Yoshio Yamaoka
BACKGROUND: Helicobacter pylori is well adapted to colonize the epithelial surface of the human gastric mucosa and can cause persistent infections. In order to infect the gastric mucosa, it has to survive in the gastric acidic pH. This organism has well developed mechanisms to neutralize the effects of acidic pH. OBJECTIVE: This review article was designed to summarize the various functional and molecular aspects by which the bacterium can combat and survive the gastric acidic pH in order to establish the persistent infections...
April 12, 2017: Helicobacter
https://www.readbyqxmd.com/read/28402041/inactivation-of-ferric-uptake-regulator-fur-attenuates-helicobacter-pylori-j99-motility-by-disturbing-the-flagellar-motor-switch-and-autoinducer-2-production
#13
Ai-Yun Lee, Cheng-Yen Kao, Yao-Kuan Wang, Ssu-Yuan Lin, Tze-Ying Lai, Bor-Shyang Sheu, Chien-Jung Lo, Jiunn-Jong Wu
BACKGROUND: Flagellar motility of Helicobacter pylori has been shown to be important for the bacteria to establish initial colonization. The ferric uptake regulator (Fur) is a global regulator that has been identified in H. pylori which is involved in the processes of iron uptake and establishing colonization. However, the role of Fur in H. pylori motility is still unclear. MATERIALS AND METHODS: Motility of the wild-type, fur mutant, and fur revertant J99 were determined by a soft-agar motility assay and direct video observation...
April 12, 2017: Helicobacter
https://www.readbyqxmd.com/read/28111844/autophagy-related-genes-in-helicobacter-pylori-infection
#14
Shingo Tanaka, Hiroyuki Nagashima, Takahiro Uotani, David Y Graham, Yoshio Yamaoka
BACKGROUND: In vitro studies have shown that Helicobacter pylori (H. pylori) infection induces autophagy in gastric epithelial cells. However, prolonged exposure to H. pylori reduces autophagy by preventing maturation of the autolysosome. The alterations of the autophagy-related genes in H. pylori infection are not yet fully understood. MATERIALS AND METHODS: We analyzed autophagy-related gene expression in H. pylori-infected gastric mucosa compared with uninfected gastric mucosa obtained from 136 Bhutanese volunteers with mild dyspeptic symptoms...
June 2017: Helicobacter
https://www.readbyqxmd.com/read/28066960/consensus-on-the-clinical-management-screening-to-treat-and-surveillance-of-helicobacter-pylori-infection-to-improve-gastric-cancer-control-on-a-nationwide-scale
#15
Bor-Shyang Sheu, Ming-Shiang Wu, Cheng-Tang Chiu, Jing-Chuan Lo, Deng-Chyang Wu, Jyh-Ming Liou, Chun-Ying Wu, Hsiu-Chi Cheng, Yi-Chia Lee, Ping-I Hsu, Chun-Chao Chang, Wei-Lun Chang, Jaw-Town Lin
BACKGROUND: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. MATERIALS AND METHODS: This consensus statement for management of H...
June 2017: Helicobacter
https://www.readbyqxmd.com/read/28297163/helicobacter-pylori-infection-in-omani-children
#16
Siham Al-Sinani, Sharef Waadallah Al-Mulaabed, Khalid Al-Naamani, Hyatt Al-Sharji
No abstract text is available yet for this article.
April 2017: Helicobacter
https://www.readbyqxmd.com/read/27933701/ccr2-mediates-helicobacter-pylori-induced-immune-tolerance-and-contributes-to-mucosal-homeostasis
#17
Xia Sun, Min Zhang, Mohamad El-Zaatari, Gray B Huffnagle, John Y Kao
BACKGROUND: We previously demonstrated that H. pylori infection leads to increased induction of regulatory T cells in local and systemic immune compartments. Here, we investigate the role of CCR2 in the tolerogenic programing of dendritic cells in a mouse model of H. pylori infection. MATERIALS AND METHODS: CCR2 deficient (CCR2KO) mice and wild-type (Wt) mice infected with H. pylori SS1 strain were analyzed by qPCR and FACS analysis. In vitro, bone marrow-derived DC on day 6 from CCR2KO and Wt mice cocultured with or without H...
April 2017: Helicobacter
https://www.readbyqxmd.com/read/27879042/high-antibiotic-resistance-of-helicobacter-pylori-and-its-effect-on-tailored-and-empiric-eradication-of-the-organism-in-lower-silesia-poland
#18
Stanisław Ferenc, Jan Gnus, Magdalena Kościelna, Małgorzata Kinda, Andriy Yarka, Luke Stewart, Wojciech Witkiewicz
BACKGROUND: At present, the resistance to antibiotics is considered the most important reason for Helicobacter pylori (HP) eradication failure. The aim of this study was to estimate the prevalence of antimicrobial resistance of HP strains and to evaluate tailored and empiric therapeutic regimens in patients with peptic ulcer disease associated with infection of this microorganism. MATERIALS AND METHODS: Between May 2011 and February 2013, 185 consecutive Polish patients with at least one positive Helicobacter pylori test (urease test, histopathologic examination, and/or culture) underwent eradication therapy...
April 2017: Helicobacter
https://www.readbyqxmd.com/read/27786400/helicobacter-pylori-colonization-and-pregnancies-complicated-by-preeclampsia-spontaneous-prematurity-and-small-for-gestational-age-birth
#19
Wouter J den Hollander, Sarah Schalekamp-Timmermans, I Lisanne Holster, Vincent W Jaddoe, Albert Hofman, Henriëtte A Moll, Guillermo I Perez-Perez, Martin J Blaser, Eric A P Steegers, Ernst J Kuipers
BACKGROUND: Preeclampsia (PE), small for gestational age (SGA), and spontaneous preterm birth (PTB) each may be complications of impaired placental function in pregnancy. Although their exact pathogenesis is still unknown, certain infectious agents seem to play a role. Helicobacter pylori (H. pylori) colonization has been associated with increased risk for PE. Our aim was to assess the association between H. pylori colonization and PE, SGA, and PTB. MATERIAL AND METHODS: We measured IgG anti-H...
April 2017: Helicobacter
https://www.readbyqxmd.com/read/27785853/helicobacter-pylori-infection-and-its-related-factors-in-junior-high-school-students-in-nagano-prefecture-japan
#20
Yoshiko Nakayama, Yingsong Lin, Minoru Hongo, Hiroya Hidaka, Shogo Kikuchi
BACKGROUND: There have been few reports on Helicobacter pylori (H. pylori) infection in asymptomatic Japanese children and adolescents. We hypothesized that the prevalence of H. pylori infection is very low among Japanese children and that clinical variables such as serum pepsinogen and iron levels are associated with H. pylori infection. MATERIALS AND METHODS: We conducted a cross-sectional analysis of a sample of 454 junior high school students aged 12-15 years in four areas in Nagano Prefecture...
April 2017: Helicobacter
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