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Michael Doulberis, Jannis Kountouras, Stergios A Polyzos, Dimitri Tzivras, Elizabeth Vardaka, Constantinos Kountouras, Dimitrios Tzilves, Georgios Kotronis, Efimia Boutsikou, Dimitra Gialamprinou, Aristomenis Exadaktylos, Panagiotis Katsinelos
No abstract text is available yet for this article.
September 12, 2018: Helicobacter
Yao-Bin Yang-Ou, Yi Hu, Yin Zhu, Nong-Hua Lu
BACKGROUND: The efficacy and safety of the addition of antioxidants to triple or quadruple therapy were unclear. MATERIALS AND METHODS: This systematic review was performed in accordance with the PRISMA 2009 guidelines. A systematic search of PubMed, EMBASE, and the Cochrane Library databases was conducted to identify potentially relevant publications using the following keywords: ([Helicobacter pylori] or [H. pylori] or [Hp]) and ([antioxidant] or [vitamin] or [N-acetylcysteine] or [curcumin] or [cranberry])...
September 6, 2018: Helicobacter
Yi Hu, Cong He, Jian-Ping Liu, Nian-Shuang Li, Chao Peng, Yao-Bin Yang-Ou, Xiao-Yu Yang, Nong-Hua Lu, Yin Zhu
BACKGROUND: Helicobacter pylori (H. pylori) infection is associated with the development of gastric cancer, although the mechanism is unclear. Herein, this study aimed to clarify the key genes and signaling pathways involved in H. pylori pathogenesis based on The Cancer Genome Atlas (TCGA) database and RNA sequencing analysis. MATERIALS AND METHODS: Forty-nine gastric cancer samples (16 with H. pylori and 33 without H. pylori) and 35 cancer-adjacent normal samples from TCGA database were analyzed by bioinformatics...
September 2, 2018: Helicobacter
Hsiu-Chi Cheng, Jyh-Ming Liou, Jiing-Chyuan Luo, Cheng-Tang Chiu, Ming-Shiang Wu, Yi-Chia Lee, Chun-Ying Wu, Deng-Chyang Wu, Ping-I Hsu, Chun-Chao Chang, Wei-Lun Chang, Jaw-Town Lin, Bor-Shyang Sheu
BACKGROUND: A consensus on the management of Helicobacter pylori has been developed. We aimed to assess whether dissemination through continuing medical education (CME) could enhance the adoption of this consensus among clinicians and to explore potential barriers to acceptance. MATERIALS AND METHODS: Four CME courses were held to disseminate the consensus. Adoption surveys were performed to evaluate participants' behavior in the past and their commitment to adopt the consensus in future clinical practice after CME...
August 29, 2018: Helicobacter
Lucie Bénéjat, Astrid Ducournau, Philippe Lehours, Francis Mégraud
BACKGROUND: Knowledge of antimicrobial susceptibility, especially to macrolides, has become crucial for the management of Helicobacter pylori infection. Our aim was to evaluate two new PCR kits able to detect H. pylori in gastric biopsies as well as the mutations associated with macrolide resistance. MATERIALS AND METHODS: Two hundred successive biopsies (received from gastroenterologists all over France) were used. The two new kits tested were Amplidiag H. pylori+ClariR from Mobidiag Espoo, Finland, and RIDA® GENE H...
August 28, 2018: Helicobacter
Ziyu Li, Xiangji Ying, Fei Shan, Jiafu Ji
BACKGROUND: Garlic may be protective against Helicobacter pylori infection and gastric cancer development. We conducted this study to quantitatively update evidence on garlic intake and gastric cancer with the inclusion of most recent cohort studies and qualitatively summarize epidemiological studies of garlic consumption and Helicobacter pylori infection. MATERIALS AND METHODS: PubMed, Embase, MEDLINE, and Cochrane Library were searched on April 2018. We conducted a meta-analysis to determine whether garlic intake reduced gastric cancer risk using random-effect models and a systematic review to summarize evidence on the association between garlic consumption and Helicobacter pylori infection...
August 28, 2018: Helicobacter
Adrian G McNicholl, Javier Molina-Infante, Alfredo J Lucendo, José Luis Calleja, Ángeles Pérez-Aisa, Inés Modolell, Xavier Aldeguer, Margalida Calafat, Luis Comino, Mercedes Ramas, Ángel Callejo, Carlos Badiola, Jordi Serra, Javier P Gisbert
OBJECTIVE: To evaluate the safety, tolerability and efficacy of a probiotic supplementation for Helicobacter pylori (H. pylori) eradication therapy. DESIGN: Consecutive adult naive patients with a diagnosis of H. pylori infection who were prescribed eradication therapy according to clinical practice (10-day triple or nonbismuth quadruple concomitant therapy) randomly received probiotics (1 × 109 colony-forming units each strain, Lactobacillus plantarum and Pediococcus acidilactici) or matching placebo...
August 23, 2018: Helicobacter
Gisela M Silva, Helena Moreira Silva, Joao Nascimento, Jean-Pierre Gonçalves, Fernando Pereira, Rosa Lima
BACKGROUND: The increasing prevalence of Helicobacter pylori (H. pylori) antimicrobial resistance, primarily for clarithromycin decreases the success of treatment. The aim of this study is to determine the local pattern of first-line antimicrobials resistance and the eradication rate. MATERIAL AND METHODS: Prospective cohort study of H. pylori infected patients (positive histological or cultural exams) treated at Centro Materno-Infantil do Norte from January of 2013 to October of 2017...
August 9, 2018: Helicobacter
Yong Xie, Zhenyu Zhang, Junbo Hong, Wenzhong Liu, Hong Lu, Yiqi Du, Weihong Wang, Jianming Xu, Xuehong Wang, Lijuan Huo, Guiying Zhang, Chunhui Lan, Xiaoyan Li, Yanqing Li, Hong Wang, Guoxin Zhang, Yin Zhu, Xu Shu, Ye Chen, Jiangbin Wang, Nonghua Lu
BACKGROUND: The efficacy of Helicobacter pylori (H. pylori) eradication has steadily declined, primarily because of antibiotic resistance. This study aimed to evaluate the efficacy and safety of furazolidone eradication therapies as initial treatments for H. pylori infection. METHODS: A national, multicenter, open-label, randomized controlled trial was performed at 16 sites across 13 provinces in China to evaluate the efficacy and safety of furazolidone-containing therapies for H...
July 22, 2018: Helicobacter
Bahadori Ali, De Witte Chloë, Agin Mehmet, De Bruyckere Sofie, Smet Annemieke, Tümgör Gökhan, Güven Gökmen Tülin, Haesebrouck Freddy, Köksal Fatih
BACKGROUND: Infections with gastric Helicobacter spp. are associated with gastritis, peptic ulceration, and malignancies. Helicobacter pylori is the most prevalent Helicobacter species colonizing the human stomach. Other gastric non-H. pylori helicobacters (NHPHs) have been described in 0.2%-6% of human patients with gastric disorders. Nevertheless, due to difficulties in the diagnosis of NHPH infections and lack of routine screening, this is most likely an underestimation of their true prevalence...
July 4, 2018: Helicobacter
Michal Kori, Ilva Daugule, Vaidotas Urbonas
Helicobacter pylori infection in children differs from infection in adults in many aspects. The rate of infection, epidemiology, clinical presentations and complications, the applicability of diagnostic tests, antibiotic resistance, treatment options, and success rates differ significantly. Due to all these differences, management guidelines for children and adults differ also substantially. In 2017, the Updated ESPGHAN and NASPGHAN Guidelines on the management of H. pylori infection in children were published, emphasizing the differences in clinical presentation and indications for treatment, stating that the primary goal of clinical investigation in children is to identify the cause of upper gastrointestinal symptoms rather than the presence of H...
September 2018: Helicobacter
Danute Ražuka-Ebela, Bianca Giupponi, Francesco Franceschi
Many studies have been performed in the last year concerning the potential role of Helicobacter pylori in different extragastric diseases, reinforcing the idea that specific microorganisms may cause diseases even far from the primary site of infection. While the role of H. pylori on idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency has been well established, there is a growing interest in other conditions, such as cardiovascular, neurologic, dermatologic, obstetric, immunologic, and metabolic diseases...
September 2018: Helicobacter
Marino Venerito, Riccardo Vasapolli, Theodoros Rokkas, Peter Malfertheiner
Gastric cancer (GC) is still the third leading cause of cancer death in both sexes worldwide. Helicobacter pylori infection is the most important risk factor for GC and, in spite of the consistent trend of a decreasing incidence, in 2015 approximately 4.4 billion individuals-more than half the world's population-were infected with H. pylori. The birth cohort pattern of decreased H. pylori infection reported in a systematic review contributes to explain the declining GC mortality in Japan. Current trends in estimated annual percentage change of GC incidence foreshadow expected reversals in both falling incidence and male predominance among US non-Hispanic whites...
September 2018: Helicobacter
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Helicobacter
Olga Sjomina, Jelizaveta Pavlova, Yaron Niv, Marcis Leja
This review provides the most recent data concerning the epidemiology of Helicobacter pylori infection. Overall, the trend of declining prevalence of H. pylori infection is continuing, with major evidence available from studies in Europe. However, in some parts of the world, for example, in some countries in the Middle East, the prevalence has remained relatively stable. A number of systematic reviews and meta-analyses have been published during the past year indicating the lowest prevalence rates of the infection in Oceania (24...
September 2018: Helicobacter
Juozas Kupcinskas, Georgina L Hold
The current article is a review of the most important, accessible, and relevant literature published between April 2017 and March 2018 on other Helicobacters and the gastric microbiome. The first part of the review focuses on literature describing non-Helicobacter pylori-Helicobacter (NHPH) infections in humans and animals whilst the subsequent section focuses specifically on the human gastric microbiome. Novel diagnostic methods as well as new NHPHs species have been identified in recent studies. Furthermore, our knowledge about the pathogenesis of NHPH infections has been further enhanced by important fundamental studies in cell lines and animal models...
September 2018: Helicobacter
Neil R O'Morain, Maria P Dore, Anthony J P O'Connor, Javier P Gisbert, Colm A O'Morain
Treatment options for the eradication of Helicobacter pylori continue to evolve. There have been many guidelines for H. pylori treatment published, which may lead to some confusion. However, most are in agreement with the most recent iteration of the Maastricht treatment guidelines. Triple therapy is still the most frequently used treatment, especially in areas of low clarithromycin resistance. Its best results are achieved when taken for a minimum of 10 days and with high-dose acid suppression. Quadruple therapy is gaining in popularity particularly in areas with increasing resistance to standard triple therapy...
September 2018: Helicobacter
Sabine Skrebinska, Francis Mégraud, Emilie Bessède
The progress this year in Helicobacter pylori diagnosis concerned essentially endoscopy and molecular techniques. New endoscopy techniques such as blue laser imaging and magnifying narrow band imaging allow the visualization of mucosal aspects representing H. pylori infection, intestinal metaplasia, and even ambiguous early gastric cancer. Several real-time PCRs have also been used either to quantify H. pylori or to detect mutations associated with clarithromycin resistance in gastric biopsies or applied on gastric juice, stool specimens, or the oral cavity...
September 2018: Helicobacter
Laimas Jonaitis, Rinaldo Pellicano, Limas Kupcinskas
The review of the most important recent publications concerning the relation of Helicobacter pylori with peptic ulcer disease (PUD), noninvestigated and functional dyspepsia, and gastroesophageal reflux disease (GERD) is presented. H. pylori remains the main etiopathogenetic factor in complicated and uncomplicated PUD. Nevertheless, the role of nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin is increasing. The novel data did not confirm that PUD caused by NSAIDs and aspirin is less symptomatic. The role of glucocorticoids, immunosuppressants, and antidepressants seems to be of some importance...
September 2018: Helicobacter
Langgeng Agung Waskito, Nina R Salama, Yoshio Yamaoka
In this review, we highlight progress in the last year in characterizing known virulence factors like flagella and the Cag type IV secretion system with sophisticated structural and biochemical approaches to yield new insight on the assembly and functions of these critical virulence determinants. Several aspects of Helicobacter pylori physiology were newly explored this year and evaluated for their functions during stomach colonization, including a fascinating role for the essential protease HtrA in allowing access of H...
September 2018: Helicobacter
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