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Romond Sia, Chloé Plouzeau, Hector Sedo Michael Godonou, Alice Guingané, Aboubacar Coulibaly, Sosthène Somda, Abdel Karim Sermé, Christophe Burucoa
No abstract text is available yet for this article.
November 12, 2018: Helicobacter
Antonio Ponzetto, John Holton
No abstract text is available yet for this article.
November 9, 2018: Helicobacter
Yi-Ying Wu, Chin-Tung Hsieh, Gregory J Tsay, Jung-Ta Kao, Ying-Ming Chiu, Dong-Chen Shieh, Yi-Ju Lee
Helicobacter pylori (H. pylori) infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, and gastric cancer. Increased T-cell infiltration is found at sites of H. pylori infection. The CCR6+ subset of CD4+ regulatory T cells (Tregs), a newly characterized subset of Tregs, has been reported to contribute to local immune inhibition. However, whether CCR6+ Tregs are present in H. pylori gastritis, and what their relationship is to disease prognosis, remains to be elucidated...
November 9, 2018: Helicobacter
Ben Da, Niraj Jani, Nikhil Gupta, Preeth Jayaram, Ravi Kankotia, Chung Yao Yu, Mario Dinis-Ribeiro, James Buxbaum
BACKGROUND & STUDY AIMS: Gastric intestinal metaplasia (GIM) is the most common precursor of gastric cancer. Our aim is to determine if presenting symptoms predict gastric cancer precursor lesions in a high-risk population. PATIENT AND METHODS: Consecutive unique patients evaluated by endoscopy for upper gastrointestinal symptoms at the Los Angeles County Hospital between 2010 and 2014 were evaluated. Presenting symptoms were classified as low- or high-risk depending on the procedure indication as coded using the Clinical Outcomes Research Initiative (CORI) system...
November 9, 2018: Helicobacter
Fernando Macías-García, Iria Bastón-Rey, Daniel de la Iglesia-García, Cristina Calviño-Suárez, Laura Nieto-García, Juan Enrique Domínguez-Muñoz
BACKGROUND: Concomitant quadruple (CQT) or bismuth-containing quadruple therapy (BQT) is recommended as first-line treatment for Helicobacter pylori infection depending on antibiotic resistance. AIM: To compare the efficacy, safety, and compliance of CQT and BQT as first-line therapy for H. pylori eradication in real clinical practice in an area of high resistance to clarithromycin. METHODS: A prospective, open, comparative cross-sectional study including dyspeptic patients >18 years with H...
October 22, 2018: Helicobacter
Natalia Dekhnich, Natalie Ivanchik, Roman Kozlov, Alexander Alimov, Andrey Steshits, Pavel Kirsov, Krunal Pandav
BACKGROUND: Efficacy of Helicobacter pylori eradication therapy depends on the chance of having a resistant H. pylori strain, which is ultimately related to the local antimicrobial resistance epidemiology. AIM: To assess H. pylori resistance to clarithromycin, amoxicillin, metronidazole, levofloxacin, and tetracycline in adult patients in the Smolensk region of Russian Federation over a 9-year period. MATERIALS AND METHODS: Biopsy samples were taken from the gastric antrum and body of 573 and 210 patients with dyspepsia symptoms and positive rapid urease test during esophagogastroduodenoscopy in 2015-2017 and 2009-2010, respectively...
October 16, 2018: Helicobacter
Nidhi Chauhan, Alfred Chin Yen Tay, Barry J Marshall, Utkarsh Jain
BACKGROUND: Helicobacter pylori, gastric cancer-causing bacteria, survive in their gastric environment of more than 50% of the world population. The presence of H. pylori in the gastric vicinity promotes the development of various diseases including peptic ulcer and gastric carcinoma. H. pylori produce and secret Vacuolating cytotoxin A (VacA), a major toxin facilitating the bacteria against the host defense system. The toxin causes multiple effects in epithelial cells and immune cells, especially T cells, B cells, and Macrophages...
October 16, 2018: Helicobacter
Masaki Murata, Mitsushige Sugimoto, Taketo Otsuka, Atsushi Nishida, Osamu Inatomi, Shigeki Bamba, Akira Andoh
BACKGROUNDS AND AIMS: Constipation is one of the most common gastrointestinal functional disorders. Recently, the gut microbiota has been implicated in the development of constipation. Helicobacter pylori infection is considered to be a possible factor influencing the gut microbiota profile. Here, we investigated the effect of H. pylori eradication therapy on symptoms of chronic constipation. METHODS: We recruited 166 H pylori-positive patients who underwent eradication therapy after endoscopy...
October 15, 2018: Helicobacter
Takuji Gotoda, Chika Takano, Chika Kusano, Sho Suzuki, Hisatomo Ikehara, Satoshi Hayakawa, Akira Andoh
OBJECTIVES: The effect of Helicobacter pylori eradication on the gut microbiota of teenagers is unknown; hence, this study aimed to assess changes in the gut microbiome after H. pylori eradication therapy in teenagers. MATERIALS AND METHODS: Changes in gut microbiota before and after H. pylori eradication were prospectively investigated in eight students without any underlying diseases, via next-generation sequencing of 16S rDNA. Twenty-four stool samples were collected, and operational taxonomic unit analysis was performed...
October 12, 2018: Helicobacter
Chang Yong Yun, Nayoung Kim, Jaebong Lee, Ju Yup Lee, Young Jae Hwang, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Dong Ho Lee
BACKGROUND: The operative link on gastric atrophy (OLGA) and operative link on gastric intestinal metaplasia (OLGIM) stages have been suggested for risk estimation of gastric cancer (GC). However, usefulness of OLGA/OLGIM systems in diffuse type of GC was not investigated so far. The aims of this study were to evaluate the OLGA/OLGIM systems in estimating the GC risk according to Lauren's classification and to investigate the interaction among the risk factors. MATERIALS AND METHODS: The OLGA/OLGIM stages were evaluated in 1398 (765 control and 633 GC patients) who were prospectively enrolled in the Seoul National University Bundang Hospital...
October 10, 2018: Helicobacter
Bálint Erőss, Benedek Tinusz, Nelli Farkas, Péter Hegyi
No abstract text is available yet for this article.
September 24, 2018: Helicobacter
Ahmed Abdel-Razik, Nasser Mousa, Walaa Shabana, Mohamed Refaey, Rania Elhelaly, Rasha Elzehery, Mostafa Abdelsalam, Ayman Elgamal, Mervat R Nassar, Atef Abu El-Soud, Ahmed S Seif, Ahmed M Tawfik, Niveen El-Wakeel, Waleed Eldars
BACKGROUND AND AIM: The relationship between Helicobacter pylori (H. pylori) and nonalcoholic fatty liver disease (NAFLD) is a matter of debate. We achieved this prospective work to study whether H. pylori infection is a risk factor for NAFLD. METHODS: A cohort multicenter pilot study of 369 adults without NAFLD at baseline was followed up for 2 years. Serum leptin, insulin, tumor necrosis factor-α, adiponectin, and interleukin-6 were measured using an enzyme-linked immunosorbent assay (ELISA)...
September 23, 2018: Helicobacter
Gracjana Krzysiek-Maczka, Aneta Targosz, Urszula Szczyrk, Malgorzata Strzałka, Zbigniew Sliwowski, Tomasz Brzozowski, Jarosław Czyz, Agata Ptak-Belowska
BACKGROUND: Major human gastrointestinal pathogen Helicobacter pylori (H. pylori) colonizes the gastric mucosa causing inflammation and severe complications including cancer, but the involvement of fibroblasts in the pathogenesis of these disorders in H. pylori-infected stomach has been little studied. Normal stroma contains few fibroblasts, especially myofibroblasts. Their number rapidly increases in the reactive stroma surrounding inflammatory region and neoplastic tissue; however, the interaction between H...
September 23, 2018: Helicobacter
Rachel Feder, Shai Posner, Yi Qin, Jiayin Zheng, Shein-Chung Chow, Katherine S Garman
BACKGROUND & AIMS: Guidelines recommend that patients with Helicobacter pylori (H. pylori)-associated peptic ulcer disease (PUD) receive H. pylori eradication therapy followed by post-treatment testing to prove eradication; however, post-treatment testing rates are suboptimal and barriers to testing are poorly understood. Our aim was to identify factors that predicted receipt of post-treatment testing. METHODS: We performed a retrospective cohort study of 152 patients with H...
September 23, 2018: Helicobacter
Farideh Siavoshi, Parastoo Saniee, Reza Malekzadeh
BACKGROUND: Helicobacter pylori resistance to more than one antibiotic is the main reason for failure in bacterial eradication in a considerable number of patients. Rifabutin (RFB) with a broad-spectrum of antimicrobial therapy has been suggested for treatment of refractory multidrug-resistant infections. METHODS: Helicobacter pylori isolates from 104 patients were examined for resistance to 5 currently used antibiotics and RFB, using agar dilution method. Twofold serial dilutions of antibiotics were used and MICs (μg/mL) determined as metronidazole (MTZ 8), clarithromycin (CLR 2), amoxicillin (AMX 1), tetracycline (TET 0...
September 19, 2018: Helicobacter
Michael Doulberis, Jannis Kountouras, Stergios A Polyzos, Dimitri Tzivras, Elizabeth Vardaka, Constantinos Kountouras, Dimitrios Tzilves, Georgios Kotronis, Efimia Boutsikou, Dimitra Gialamprinou, Aristomenis Exadaktylos, Panagiotis Katsinelos
No abstract text is available yet for this article.
September 12, 2018: Helicobacter
Shuanghui Luo, Wei Liu, Zhiqin Zeng, Feng Ye, Chupeng Hu, Ningyin Xu, An Huang, Tao Xi, Yingying Xing
BACKGROUND: Toxic adjuvant is considered as an indispensable constituent for oral Helicobacter pylori (H. pylori) vaccines. However, the elaborate role of toxic adjuvant in the initiation of adaptive immune response is largely undescribed. MATERIALS AND METHODS: We employed an acid-resistant HP55/PLGA nanoparticles (NPs) delivery system encapsulating three antigens (Hsp, Nap, and Lpp20) from H. pylori and accompanied with three adjuvants (LPS, CpG, and chimeric flagellum (CF)) to explore the underlying mechanism of the adjuvant constituent...
September 11, 2018: Helicobacter
Yao-Bin Yang-Ou, Yi Hu, Yin Zhu, Nong-Hua Lu
BACKGROUND: The efficacy and safety of the addition of antioxidants to triple or quadruple therapy were unclear. MATERIALS AND METHODS: This systematic review was performed in accordance with the PRISMA 2009 guidelines. A systematic search of PubMed, EMBASE, and the Cochrane Library databases was conducted to identify potentially relevant publications using the following keywords: ([Helicobacter pylori] or [H. pylori] or [Hp]) and ([antioxidant] or [vitamin] or [N-acetylcysteine] or [curcumin] or [cranberry])...
September 6, 2018: Helicobacter
Yi Hu, Cong He, Jian-Ping Liu, Nian-Shuang Li, Chao Peng, Yao-Bin Yang-Ou, Xiao-Yu Yang, Nong-Hua Lu, Yin Zhu
BACKGROUND: Helicobacter pylori (H. pylori) infection is associated with the development of gastric cancer, although the mechanism is unclear. Herein, this study aimed to clarify the key genes and signaling pathways involved in H. pylori pathogenesis based on The Cancer Genome Atlas (TCGA) database and RNA sequencing analysis. MATERIALS AND METHODS: Forty-nine gastric cancer samples (16 with H. pylori and 33 without H. pylori) and 35 cancer-adjacent normal samples from TCGA database were analyzed by bioinformatics...
October 2018: Helicobacter
Hsiu-Chi Cheng, Jyh-Ming Liou, Jiing-Chyuan Luo, Cheng-Tang Chiu, Ming-Shiang Wu, Yi-Chia Lee, Chun-Ying Wu, Deng-Chyang Wu, Ping-I Hsu, Chun-Chao Chang, Wei-Lun Chang, Jaw-Town Lin, Bor-Shyang Sheu
BACKGROUND: A consensus on the management of Helicobacter pylori has been developed. We aimed to assess whether dissemination through continuing medical education (CME) could enhance the adoption of this consensus among clinicians and to explore potential barriers to acceptance. MATERIALS AND METHODS: Four CME courses were held to disseminate the consensus. Adoption surveys were performed to evaluate participants' behavior in the past and their commitment to adopt the consensus in future clinical practice after CME...
October 2018: Helicobacter
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