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Bahadori Ali, De Witte Chloë, Agin Mehmet, De Bruyckere Sofie, Smet Annemieke, Tümgör Gökhan, Güven Gökmen Tülin, Haesebrouck Freddy, Köksal Fatih
BACKGROUND: Infections with gastric Helicobacter spp. are associated with gastritis, peptic ulceration, and malignancies. Helicobacter pylori is the most prevalent Helicobacter species colonizing the human stomach. Other gastric non-H. pylori helicobacters (NHPHs) have been described in 0.2%-6% of human patients with gastric disorders. Nevertheless, due to difficulties in the diagnosis of NHPH infections and lack of routine screening, this is most likely an underestimation of their true prevalence...
July 4, 2018: Helicobacter
Arezoo Bassagh, Mehdi Hayatbakhsh Abasi, Tiziana Larussa, Motahareh Ghazizadeh, Maryam Nemati, Ehsan Mirkamandar, Abdollah Jafarzadeh
BACKGROUND: IL-35 modulates immune and inflammatory responses during infections. Here, we investigated IL-35 levels and a single nucleotide polymorphism, rs3761548, in FOXP3 gene in Helicobacter pylori-infected patients with peptic ulcer (PU), to clarify possible associations. MATERIALS AND METHODS: This study includes 100 H. pylori-infected PU patients, 100 H. pylori-infected asymptomatic subjects (AS), and 100 noninfected healthy subjects (NHSs). Serum IL-35 levels and the genotyping were determined using ELISA and RFLP-PCR methods, respectively...
June 25, 2018: Helicobacter
Bálint Erőss, Nelli Farkas, Áron Vincze, Benedek Tinusz, László Szapáry, András Garami, Márta Balaskó, Patrícia Sarlós, László Czopf, Hussain Alizadeh, Zoltán Rakonczay, Tamás Habon, Péter Hegyi
INTRODUCTION: The prevalence of Helicobacter pylori infection (HPI) has been decreasing in developed countries, with an increasing prevalence of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) at the same time. The aim of our meta-analysis was to quantify the risk of BE in the context of HPI. METHODS: A systematic search was conducted in 3 databases for studies on BE with data on prevalence of HPI from inception until December 2016. Odds ratios for BE in HPI were calculated by the random effects model with subgroup analyses for geographical location, presence of dysplasia in BE, and length of the BE segment...
June 25, 2018: Helicobacter
Kosuke Sakitani, Toshihiro Nishizawa, Masahide Arita, Shuntaro Yoshida, Yosuke Kataoka, Daisuke Ohki, Hiroharu Yamashita, Yoshihiro Isomura, Akira Toyoshima, Hidenobu Watanabe, Toshiro Iizuka, Yutaka Saito, Junko Fujisaki, Naohisa Yahagi, Kazuhiko Koike, Osamu Toyoshima
BACKGROUND: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. MATERIALS AND METHODS: All-cause death rates and gastric cancer-specific death rates in gastric cancer patients who received successful H...
June 20, 2018: Helicobacter
Rocco Maurizio Zagari, Alessandra Romiti, Enzo Ierardi, Antonietta G Gravina, Alba Panarese, Giuseppe Grande, Edoardo Savarino, Giovanni Maconi, Elisa Stasi, Leonardo Henry Eusebi, Fabio Farinati, Rita Conigliaro, Franco Bazzoli, Marco Romano
BACKGROUND: Clinical trials have shown a good efficacy of the "three-in-one" formulation of bismuth quadruple therapy (BQT) for Helicobacter (H.) pylori eradication. We aimed to assess the efficacy and safety of the three-in-one BQT in clinical practice, and investigate the effect of probiotic supplementation, in Italy. MATERIALS AND METHODS: A retrospective database, multicentre observational study was conducted in seven Italian Hospitals. Consecutive H...
June 20, 2018: Helicobacter
Inês Lopo, Diogo Libânio, Inês Pita, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes
BACKGROUND: Portugal presents both a high prevalence of Helicobacter pylori (Hp) infection and a high prevalence of antibiotic resistance. However, conclusive data on its magnitude are lacking. We aimed at summarizing the existing data. MATERIALS AND METHODS: A systematic review was conducted after searching in two databases (PubMed and SciELO). Meta-analysis was performed, and comparison of resistance rates between children and adults and by type of resistance (primary and secondary) was made...
June 17, 2018: Helicobacter
Ping-I Hsu, Chao-Yu Pan, John Y Kao, Feng-Woei Tsay, Nan-Jing Peng, Sung-Shuo Kao, Huay-Min Wang, Tzung-Jiun Tsai, Deng-Chyang Wu, Chien-Lin Chen, Kuo-Wang Tsai
BACKGROUND: Bismuth quadruple therapy is the treatment of choice for the first-line therapy of Helicobacter pylori infection in areas of high clarithromycin resistance. Currently, the impact of the promising treatment on gut microbiota remains unclear. AIM: To investigate the short-term and long-term impacts of bismuth quadruple therapy on gut microbiota. METHODS: Adult patients with H. pylori-related gastritis were treated with 14-day bismuth quadruple therapy...
June 13, 2018: Helicobacter
John Robotis, Sotirios Tsiodras, Theodore Rokkas
No abstract text is available yet for this article.
June 13, 2018: Helicobacter
Boldbaatar Gantuya, Dashdorj Bolor, Khasag Oyuntsetseg, Yansan Erdene-Ochir, Ruvjir Sanduijav, Duger Davaadorj, Tegshee Tserentogtokh, Dashdorj Azzaya, Tomohisa Uchida, Takeshi Matsuhisa, Yoshio Yamaoka
BACKGROUND: The incidence and mortality of gastric cancer in Mongolia is among the highest in the world. METHODS: This was a case-control study in which upper gastrointestinal endoscopy, gastric histology, Helicobacter pylori testing, and risk factor questionnaires were obtained. Histologic subtypes were determined by Lauren's classification. RESULTS: We enrolled 45 gastric cancer and 108 non-gastric cancer patients. Gastric cancers were located in upper part of stomach in 53...
June 8, 2018: Helicobacter
Samaneh Saberi, Behshad Pournasr, Zahra Farzaneh, Maryam Esmaeili, Mahmoud Eshagh Hosseini, Hossein Baharvand, Marjan Mohammadi
BACKGROUND: Most two- dimensional in vitro models for studying host- H. pylori interactions rely on tumor-derived cell lines, which harbor malignant alterations. The recent development of human gastric organoids has overcome this limitation and provides a highly sophisticated, yet costly, short-term model for H. pylori infection, with restricted use in low-budget centers. METHOD: Tissue specimens from upper, middle, and lower stomachs of H. pylori-negative volunteers were collectively dispersed and cultured on mouse embryonic fibroblast (MEF) or collagen-coated plates...
May 17, 2018: Helicobacter
Aysel Ünlüsoy Aksu, Güldal Yılmaz, Ödül Eğritaş Gürkan, Sinan Sarı, Buket Dalgıç
BACKGROUND: The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) eradication on dyspepsia symptom scores in children with functional dyspepsia (FD). MATERIALS AND METHODS: One hundred and fifty functional dyspeptic children (ages 8-18 years, mean: 13.3 ± 2.84 years; 30% male) were enrolled to this prospective study. Upper gastrointestinal endoscopy was performed on all patients, and the samples from the gastric antrum and corpus were obtained for the existence of H...
August 2018: Helicobacter
Min Li, Tadayuki Oshima, Tomoki Horikawa, Katsuyuki Tozawa, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
BACKGROUND: Vonoprazan is a novel gastric acid suppressant that is applied in Japan to treat gastric diseases including Helicobacter pylori (H. pylori) infection. This meta-analysis aimed to summarize the ability of vonoprazan to eradicate clarithromycin-susceptible and clarithromycin-resistant H. pylori strains. MATERIALS AND METHODS: A systematic search was performed using PubMed, EMBASE, Web of Science, and Cochrane Library. Studies were included if they evaluated eradication rates of vonoprazan-based and conventional PPI-based triple therapies and checked for clarithromycin susceptibility of H...
August 2018: Helicobacter
Benjamin Blümel, Hanna Goelz, Manfred Kist, Erik-Oliver Glocker
BACKGROUND: Antimicrobial susceptibility of Helicobacter (H.) pylori is usually determined by phenotypic methods. When H. pylori cannot be grown owing to contaminations or delay in transport of gastric tissue samples to the microbiological laboratory, molecular genetic testing is a reasonable alternative. The aim of this retrospective study was to assess the outcome of salvage eradication treatments based on molecular genetic susceptibility testing. METHODS: Data on 144 H...
August 2018: Helicobacter
Mahmoud Ramadan
No abstract text is available yet for this article.
August 2018: Helicobacter
Xiaohua Long, Qi Chen, Lou Yu, Xiao Liang, Wenzhong Liu, Hong Lu
BACKGROUND: Helicobacter pylori (H. pylori) eradication has become increasingly difficult especially for penicillin allergy patients. AIMS: To evaluate the efficacy of adding bismuth or high-dose metronidazole to an H. pylori eradication regimen containing a proton-pump inhibitor, clarithromycin, and metronidazole in patients allergic to penicillin. METHODS: Pilot study in which penicillin-allergic, treatment-naive subjects were randomized (1:1) to 14-day esomeprazole (20 mg q12h), clarithromycin (500 mg q12h), and high dose of metronidazole (400 mg q6h) with (BECM group) or without (ECM group) bismuth (600 mg q12h)...
June 2018: Helicobacter
Sadaf Saghier, Steven M Schwarz, Virginia Anderson, Raavi Gupta, Amin Heidarian, Simon S Rabinowitz
OBJECTIVES: Helicobacter pylori (Hp) are the most common agents causing gastric mucosal injury worldwide. Foveolar hyperplasia is a key component of the stomach's reaction to injury. This study examines histopathologic characteristics associated with Helicobacter pylori and with non- Helicobacter pylori-associated gastropathy in children and adolescents, and compares the prevalence of foveolar hyperplasia among these disease subgroups and normal control subjects. METHODS: Eighty-one gastric antral and corpus biopsies from subjects 2-19 years of age were studied...
June 2018: Helicobacter
Elizabeth A Marcus, George Sachs, David R Scott
BACKGROUND: The pathogen Helicobacter pylori encounters many stressors as it transits to and infects the gastric epithelium. Gastric acidity is the predominate stressor encountered by the bacterium during initial infection and establishment of persistent infection. H. pylori initiates a rapid response to acid to maintain intracellular pH and proton motive force appropriate for a neutralophile. However, acid sensing by H. pylori may also serve as a transcriptional trigger to increase the levels of other pathogenic factors needed to subvert host defenses such as acid acclimation, antioxidants, flagellar synthesis and assembly, and CagA secretion...
June 2018: Helicobacter
Neus Muñoz, Jordi Sánchez-Delgado, Mireia Baylina, Ignasi Puig, Sheila López-Góngora, David Suarez, Xavier Calvet
BACKGROUND: Multiple Helicobacter pylori second-line schedules have been described as potentially useful. It remains unclear, however, which are the best combinations, and which features of second-line treatments are related to better cure rates. The aim of this study was to determine that second-line treatments achieved excellent (>90%) cure rates by performing a systematic review and when possible a meta-analysis. A meta-regression was planned to determine the characteristics of treatments achieving excellent cure rates...
June 2018: Helicobacter
Tao-Tao Yang, Na Cao, Hai-Hui Zhang, Jian-Bo Wei, Xiao-Xia Song, Dong-Min Yi, Shuai-Heng Chao, Li-Da Zhang, Ling-Fei Kong, Shuang-Yin Han, Yu-Xiu Yang, Song-Ze Ding
BACKGROUND: Our previous works have demonstrated that Helicobacter pylori (Hp) infection can alter histone H3 serine 10 phosphorylation status in gastric epithelial cells. However, whether Helicobacter pylori-induced histone H3 serine 10 phosphorylation participates in gastric carcinogenesis is unknown. We investigate the expression of histone H3 serine 10 phosphorylation in various stages of gastric disease and explore its clinical implication. MATERIALS AND METHODS: Stomach biopsy samples from 129 patients were collected and stained with histone H3 serine 10 phosphorylation, Ki67, and Helicobacter pylori by immunohistochemistry staining, expressed as labeling index...
June 2018: Helicobacter
Tae Jun Kim, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim, Sung Noh Hong
No abstract text is available yet for this article.
June 2018: Helicobacter
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