journal
MENU ▼
Read by QxMD icon Read
search

Helicobacter

journal
https://www.readbyqxmd.com/read/29774633/a-simple-and-cost-efficient-adherent-culture-platform-for-human-gastric-primary-cells-as-an-in-vitro-model-for-helicobacter-pylori-infection
#1
Samaneh Saberi, Behshad Pournasr, Zahra Farzaneh, Maryam Esmaeili, Mahmoud Eshagh Hosseini, Hossein Baharvand, Marjan Mohammadi
BACKGROUND: Most two- dimensional in vitro models for studying host- H. pylori interactions rely on tumor-derived cell lines, which harbor malignant alterations. The recent development of human gastric organoids has overcome this limitation and provides a highly sophisticated, yet costly, short-term model for H. pylori infection, with restricted use in low-budget centers. METHOD: Tissue specimens from upper, middle, and lower stomachs of H. pylori-negative volunteers were collectively dispersed and cultured on mouse embryonic fibroblast (MEF) or collagen-coated plates...
May 17, 2018: Helicobacter
https://www.readbyqxmd.com/read/29696736/bismuth-improves-efficacy-of-proton-pump-inhibitor-clarithromycin-metronidazole-triple-helicobacter-pylori-therapy-despite-a-high-prevalence-of-antimicrobial-resistance
#2
Xiaohua Long, Qi Chen, Lou Yu, Xiao Liang, Wenzhong Liu, Hong Lu
BACKGROUND: Helicobacter pylori (H. pylori) eradication has become increasingly difficult especially for penicillin allergy patients. AIMS: To evaluate the efficacy of adding bismuth or high-dose metronidazole to an H. pylori eradication regimen containing a proton-pump inhibitor, clarithromycin, and metronidazole in patients allergic to penicillin. METHODS: Pilot study in which penicillin-allergic, treatment-naive subjects were randomized (1:1) to 14-day esomeprazole (20 mg q12h), clarithromycin (500 mg q12h), and high dose of metronidazole (400 mg q6h) with (BECM group) or without (ECM group) bismuth (600 mg q12h)...
April 25, 2018: Helicobacter
https://www.readbyqxmd.com/read/29696734/pediatric-helicobacter-pylori-gastropathy-demonstrates-a-unique-pattern-of-gastric-foveolar-hyperplasia
#3
Sadaf Saghier, Steven M Schwarz, Virginia Anderson, Raavi Gupta, Amin Heidarian, Simon S Rabinowitz
OBJECTIVES: Helicobacter pylori (Hp) are the most common agents causing gastric mucosal injury worldwide. Foveolar hyperplasia is a key component of the stomach's reaction to injury. This study examines histopathologic characteristics associated with Helicobacter pylori and with non- Helicobacter pylori-associated gastropathy in children and adolescents, and compares the prevalence of foveolar hyperplasia among these disease subgroups and normal control subjects. METHODS: Eighty-one gastric antral and corpus biopsies from subjects 2-19 years of age were studied...
April 25, 2018: Helicobacter
https://www.readbyqxmd.com/read/29696729/acid-regulated-gene-expression-of-helicobacter-pylori-insight-into-acid-protection-and-gastric-colonization
#4
Elizabeth A Marcus, George Sachs, David R Scott
BACKGROUND: The pathogen Helicobacter pylori encounters many stressors as it transits to and infects the gastric epithelium. Gastric acidity is the predominate stressor encountered by the bacterium during initial infection and establishment of persistent infection. H. pylori initiates a rapid response to acid to maintain intracellular pH and proton motive force appropriate for a neutralophile. However, acid sensing by H. pylori may also serve as a transcriptional trigger to increase the levels of other pathogenic factors needed to subvert host defenses such as acid acclimation, antioxidants, flagellar synthesis and assembly, and CagA secretion...
April 25, 2018: Helicobacter
https://www.readbyqxmd.com/read/29663581/systematic-review-meta-analysis-and-meta-regression-successful-second-line-treatment-for-helicobacter-pylori
#5
REVIEW
Neus Muñoz, Jordi Sánchez-Delgado, Mireia Baylina, Ignasi Puig, Sheila López-Góngora, David Suarez, Xavier Calvet
BACKGROUND: Multiple Helicobacter pylori second-line schedules have been described as potentially useful. It remains unclear, however, which are the best combinations, and which features of second-line treatments are related to better cure rates. The aim of this study was to determine that second-line treatments achieved excellent (>90%) cure rates by performing a systematic review and when possible a meta-analysis. A meta-regression was planned to determine the characteristics of treatments achieving excellent cure rates...
April 16, 2018: Helicobacter
https://www.readbyqxmd.com/read/29656498/helicobacter-pylori-infection-induced-h3ser10-phosphorylation-in-stepwise-gastric-carcinogenesis-and-its-clinical-implications
#6
Tao-Tao Yang, Na Cao, Hai-Hui Zhang, Jian-Bo Wei, Xiao-Xia Song, Dong-Min Yi, Shuai-Heng Chao, Li-Da Zhang, Ling-Fei Kong, Shuang-Yin Han, Yu-Xiu Yang, Song-Ze Ding
BACKGROUND: Our previous works have demonstrated that Helicobacter pylori (Hp) infection can alter histone H3 serine 10 phosphorylation status in gastric epithelial cells. However, whether Helicobacter pylori-induced histone H3 serine 10 phosphorylation participates in gastric carcinogenesis is unknown. We investigate the expression of histone H3 serine 10 phosphorylation in various stages of gastric disease and explore its clinical implication. MATERIALS AND METHODS: Stomach biopsy samples from 129 patients were collected and stained with histone H3 serine 10 phosphorylation, Ki67, and Helicobacter pylori by immunohistochemistry staining, expressed as labeling index...
April 15, 2018: Helicobacter
https://www.readbyqxmd.com/read/29644785/age-and-gender-may-be-the-key-points-in-hyperglycemic-patients-with-helicobacter-pylori-infection-combined-colorectal-adenoma-author-s-reply
#7
LETTER
Tae Jun Kim, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim, Sung Noh Hong
No abstract text is available yet for this article.
April 11, 2018: Helicobacter
https://www.readbyqxmd.com/read/29635869/the-epidemiology-of-helicobacter-pylori-infection-in-europe-and-the-impact-of-lifestyle-on-its-natural-evolution-toward-stomach-cancer-after-infection-a-systematic-review
#8
REVIEW
Kimberly Venneman, Inge Huybrechts, Marc J Gunter, Lieve Vandendaele, Rolando Herrero, Koen Van Herck
BACKGROUND: Helicobacter pylori is a recognized cause of stomach cancer, but only a fraction of infected subjects develop cancer. This systematic review 1, summarizes the prevalence of infection with this bacterium in Europe; and 2, reviews the possible impact of particular lifestyles in progression from infection to stomach cancer. MATERIALS AND METHODS: A systematic literature search was conducted in two databases by two independent investigators. Studies describing prevalence of infection among European healthy adult populations and worldwide studies analyzing the impact of lifestyle factors in association with H...
April 10, 2018: Helicobacter
https://www.readbyqxmd.com/read/29600573/the-association-between-helicobacter-pylori-infection-and-the-risk-of-advanced-colorectal-neoplasia-may-differ-according-to-age-and-cigarette-smoking
#9
Hyunsung Park, Jae Jun Park, Yoo Mi Park, Su Jung Baik, Hyun Ju Lee, Da Hyun Jung, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
BACKGROUND: The association between Helicobacter pylori infection and advanced colorectal neoplasia (ACN) remains controversial. This study aimed to clarify the association between H. pylori infection and ACN according to age groups. METHODS: We retrospectively analyzed the association between H. pylori infection and ACN in patients aged <50 and ≥50 years receiving a health checkup that included colonoscopy. Helicobacter pylori positivity was determined by the results of serum anti-H...
March 29, 2018: Helicobacter
https://www.readbyqxmd.com/read/29582503/th-17-response-and-antimicrobial-peptide-expression-are-uniformly-expressed-in-gastric-mucosa-of-helicobacter-pylori-infected-patients-independently-of-their-clinical-outcomes
#10
Julie Cremniter, Charles Bodet, David Tougeron, Xavier Dray, Joëlle Guilhot, Jean-François Jégou, Franck Morel, Jean-Claude Lecron, Christine Silvain, Christophe Burucoa
BACKGROUND: The pathological determinism of H. pylori infection is explained by complex interplay between bacterial virulence and host inflammatory response. In a large prospective multicenter clinical study, Th17 response, expression of antimicrobial peptides (AMPs), cagA and vacA status, and bacterial density were investigated in the gastric mucosa of H. pylori -infected patients. MATERIALS AND METHODS: Gastric inflammatory response was analyzed by RT-qPCR for quantification of Th17 cytokines (IL-17A, IL-22), CXCL-8, and AMPs (BD2 and S100A9) mRNA levels in gastric biopsies...
March 27, 2018: Helicobacter
https://www.readbyqxmd.com/read/29537130/prevalence-of-helicobacter-pylori-among-alaskans-factors-associated-with-infection-and-comparison-of-urea-breath-test-and-anti-helicobacter-pylori-igg-antibodies
#11
Karen M Miernyk, Lisa R Bulkow, Benjamin D Gold, Michael G Bruce, Debby H Hurlburt, Patricia M Griffin, David L Swerdlow, Kim Cook, Thomas W Hennessy, Alan J Parkinson
BACKGROUND: Helicobacter pylori is one of the most common human infections in the world, and studies in Alaska Native people, as well as other Indigenous peoples, have shown a high prevalence of this gastric infection. This study was undertaken to determine the prevalence of H. pylori infection by urea breath test (UBT) and anti- H. pylori IgG among Alaskans living in four regions of the state and to identify factors associated with infection. METHODS: A convenience sample of persons > 6 months old living in five rural and one urban Alaskan community were recruited from 1996 to 1997...
March 14, 2018: Helicobacter
https://www.readbyqxmd.com/read/29528162/antibiotics-resistance-of-helicobacter-pylori-in-children-with-upper-gastrointestinal-symptoms-in-hangzhou-china
#12
Xiaoli Shu, Guofeng Yin, Mingnan Liu, Kerong Peng, Hong Zhao, Mizu Jiang
BACKGROUND: The decreasing eradication rate of Helicobacter pylori is mainly because of the progressive increase in its resistance to antibiotics. Studies on antimicrobial susceptibility of H. pylori in children are limited. This study aimed to investigate the resistance rates and patterns of H. pylori strains isolated from children. MATERIALS AND METHODS: Gastric mucosa biopsy samples obtained from children who had undergone upper gastrointestinal endoscopy were cultured for H...
March 12, 2018: Helicobacter
https://www.readbyqxmd.com/read/29520884/the-histologic-detection-of-helicobacter-pylori-in-seropositive-subjects-is-affected-by-pathology-and-secretory-ability-of-the-stomach
#13
Jun-Hyun Kim, Sun-Young Lee, Sang Pyo Lee, Jeong Hwan Kim, In-Kyung Sung, Hyung Seok Park, Chan Sup Shim, Hye Seung Han
BACKGROUND: Helicobacter pylori is unevenly distributed in hypochlorhydric environments. The study aim was to elucidate the risk factors for a negative Giemsa staining finding in seropositive subjects by measuring the secretory ability of the stomach. METHODS: Subjects aged over 18 years were included consecutively after endoscopic biopsy at gastric lesions with color or structural changes. Blood was sampled for the serum pepsinogen (PG) assay and H. pylori serology test...
March 8, 2018: Helicobacter
https://www.readbyqxmd.com/read/29520881/beneficial-effect-of-burdock-complex-on-asymptomatic-helicobacter-pylori-infected-subjects-a-randomized-double-blind-placebo-controlled-clinical-trial
#14
Chi-Hua Yen, Hui-Fang Chiu, Su-Yu Huang, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kamesh Venkatakrishnan, Chin-Kun Wang
BACKGROUND: Burdock complex (BC) constitutes of burdock (Arctium lappa), angelica (Angelica sinensis), gromwell (Lithospermum erythrorhizon), and sesame (Sesamum indicum) oil, which are commonly used in traditional Chinese medicine (TCM) for treating various disorders. This study intended to examine the anti-H. pylori activity of BC on AGS cell model as well as in asymptomatic H. pylori-infected subjects. MATERIALS AND METHODS: AGS cell incubated with H. pylori and treated with BC to evaluate the minimum inhibition concentration (MIC), cell viability (MTT) anti-adhesion activity, and inflammatory markers...
March 8, 2018: Helicobacter
https://www.readbyqxmd.com/read/29498154/helicobacter-pylori-and-gastric-cancer-in-alaskan-natives-time-to-stop-studyingh-pylori-and-to-eradicate-it
#15
EDITORIAL
Yi-Chia Lee, Masahiro Asaka, David Y Graham
No abstract text is available yet for this article.
March 2, 2018: Helicobacter
https://www.readbyqxmd.com/read/29512258/fifth-chinese-national-consensus-report-on-the-management-of-helicobacter-pylori-infection
#16
Wen Zhong Liu, Yong Xie, Hong Lu, Hong Cheng, Zhi Rong Zeng, Li Ya Zhou, Ye Chen, Jiang Bin Wang, Yi Qi Du, Nong Hua Lu
BACKGROUND: Since the 'Fourth Chinese National Consensus Report on the management of H. pylori infection' was published in 2012, three important consensuses (Kyoto global consensus report on H. pylori gastritis, The Toronto Consensus for the Treatment of H. pylori Infection in Adults and Management of H. pylori infection-the Maastricht V/Florence Consensus Report) have been published regarding the management of H. pylori infection. MATERIALS AND METHODS: A Delphi method was adopted to develop the consensus of relevant 'statements'...
April 2018: Helicobacter
https://www.readbyqxmd.com/read/29504247/anti-helicobacter-pylori-therapy-in-localized-gastric-mucosa-associated-lymphoid-tissue-lymphoma-a-prospective-nationwide-multicenter-study-in-japan
#17
Katsuya Sugizaki, Akira Tari, Yasuhiko Kitadai, Ichiro Oda, Shotaro Nakamura, Tadashi Yoshino, Toshiro Sugiyama
BACKGROUND: Helicobacter pylori eradication therapy was approved in Japan for the first-line, standard treatment of H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Although several retrospective studies or small-scale single-center studies have been reported, a prospective, large-scale, nationwide, multicenter study has not been reported from Japan. MATERIALS AND METHODS: We conducted a prospective, nationwide, multicenter study to evaluate the clinical efficacy of rabeprazole-based triple H...
April 2018: Helicobacter
https://www.readbyqxmd.com/read/29504209/brief-report-lactobacillus-bulgaricus-glb44-proviotic-%C3%A2-plus-esomeprazole-for-helicobacter-pylori-eradication-a-pilot-study
#18
Antone R Opekun, Savannah A Gonzales, Mahmoud A Al-Saadi, David Y Graham
BACKGROUND: Recent studies of Lactobacillus delbrueckii subsp. bulgaricus GLB44 plus a proton-pump inhibitor (PPI) reported cures of more than 90% of patients with active Helicobacter pylori infections. AIM: To confirm the high H. pylori cure rates reported previously. METHOD: A pilot study was done in healthy H. pylori-infected volunteers using 3-gram sachet (3 billion cells) of L. delbrueckii GLB44 plus 22.3 mg of esomeprazole b.i.d...
April 2018: Helicobacter
https://www.readbyqxmd.com/read/29488678/monotherapy-with-a-novel-intervenolin-derivative-as-1934-is-an-effective-treatment-for-helicobacter-pylori-infection
#19
Tomokazu Ohishi, Tohru Masuda, Hikaru Abe, Chigusa Hayashi, Hayamitsu Adachi, Shun-Ichi Ohba, Masayuki Igarashi, Takumi Watanabe, Hitomi Mimuro, Eri Amalia, Daniel Ken Inaoka, Kota Mochizuki, Kiyoshi Kita, Masakatsu Shibasaki, Manabu Kawada
BACKGROUND: Helicobacter pylori (H. pylori) infection causes various gastrointestinal diseases including gastric cancer. Hence, eradication of this infection could prevent these diseases. The most popular first-line treatment protocol to eradicate H. pylori is termed "triple therapy" and consists of a proton pump inhibitor (PPI), clarithromycin, and amoxicillin or metronidazole. However, the antibiotics used to treat H. pylori infection are hindered by the antibiotics-resistant bacteria and by their antimicrobial activity against intestinal bacteria, leading to side effects...
April 2018: Helicobacter
https://www.readbyqxmd.com/read/29480566/high-prevalence-of-helicobacter-pylori-clarithromycin-resistance-mutations-among-seattle-patients-measured-by-droplet-digital-pcr
#20
Sarah Talarico, Andrew S Korson, Christina K Leverich, Stephanie Park, Florencia G Jalikis, Melissa P Upton, Elizabeth Broussard, Nina R Salama
BACKGROUND: Treatment of Helicobacter pylori infection is often empiric; however, current guidelines for management of Helicobacter pylori infection advise against the use of standard triple therapy (clarithromycin, amoxicillin, and proton-pump inhibitor) when clarithromycin resistance exceeds 20%. We developed and tested a new culture-free assay to detect clarithromycin resistance-conferring mutations to determine the prevalence of H. pylori clarithromycin resistance in patients from the United States Pacific Northwest...
April 2018: Helicobacter
journal
journal
32491
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"