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Cancer Biotherapy & Radiopharmaceuticals

In Sun Kim, Hyeon-Soo Kim, Minjoo Kim, Jeongil Kwon, Eun-Mi Kim, Hyosook Hwang, Phil-Sun Oh, Seok Tae Lim, Myung-Hee Sohn, Dong Hyun Kim, Hwan-Jeong Jeong
Histone deacetylases (HDACs) are an important regulator of expression and activity of numerous proteins in terms of epigenetic aberrations. This makes HDACs attractive for antitumor therapy and imaging in certain cancers. The authors report the radiochemical synthesis of 2-[18 F]fluoroethyltriazolesuberohydroxamine acid ([18 F]FETSAHA) as a HDAC-targeted radiolabel probe for positron imaging tomography/computed tomography. The authors also evaluated the in vivo tumor targeting in subcutaneously implanted RR1022 rats...
March 2, 2018: Cancer Biotherapy & Radiopharmaceuticals
Lin Wang, Bing Tang, Heng Han, Dan Mao, Jie Chen, Yun Zeng, Min Xiong
OBJECTIVE: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays a positive regulatory role on cell autophagy through inhibiting PI3K/AKT/mammalian target of rapamycin (mTOR) signaling pathway. miR-155 plays a critical role in osteosarcoma occurrence and chemoresistance. Bioinformatics analysis revealed the targeted binding site between miR-155 and the 3'-UTR (untranslated region) of PTEN mRNA. This study investigated the role of miR-155 in regulating osteosarcoma cell autophagy, chemosensitivity to Adriamycin (ADM), and PTEN-PI3K/AKT/mTOR signaling pathway...
February 7, 2018: Cancer Biotherapy & Radiopharmaceuticals
Azadeh Mikaeili, Mostafa Erfani, Mohammad Shafiei, Farzad Kobarfard, Khosrou Abdi, Omid Sabzevari
Due to high expression of CXCR4 (CXC chemokine receptor type 4) receptors in many tumors and metastasis, synthesis and labeling of CXCR4 receptor-targeted analogs as tumor imaging agents have been encouraged. Herein, CXCR4 receptor-targeted peptide antagonist was prepared and thereafter its labeling with 99mTc by a bifunctional chelating agent and tricine coligand was developed. Radiotracer purity, stability, and tumor cell binding were assessed. Bioevaluation of radiotracer was performed in mice bearing xenograft tumor...
February 1, 2018: Cancer Biotherapy & Radiopharmaceuticals
Mohini Guleria, Tapas Das, Jeyachitra Amirdhanayagam, Haladhar D Sarma, Ashutosh Dash
PURPOSE: Both NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) and DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) derivatives have been used as bifunctional chelating agents (BFCAs) for the preparation of 68Ga-labeled target-specific agents having potential for positron emission tomography (PET) imaging of cancerous lesions. In the present work, the authors have attempted a comparative pharmacokinetic evaluation between 68Ga-labeled porphyrins prepared using NOTA and DOTA derivatives as the BFCAs...
January 26, 2018: Cancer Biotherapy & Radiopharmaceuticals
Guohao Lu, Wanling Shi, Hongyu Zheng
BACKGROUND: Gastric carcinoma is the most popular cancer worldwide. Anoctamin-1 is a calcium-activated channel and highly expressed in various tumors. A previous study indicated that suppressed Anoctamin-1 expression decreased cancer cell proliferation or migration. As a signal transduction and transcription activator, STAT6 is a novel agonist for Anoctamin-1 promoter. However, its role in tumor cell proliferation or migration remains unclear. Therefore, this study aimed to suppress STAT6 and Anoctamin-1 protein expression in gastric cancer cells to test the inhibitory effects on gastric cancer cell migration or invasion...
February 2018: Cancer Biotherapy & Radiopharmaceuticals
Xiao-Ping Zhang, Ying-Dong Li, Lu-Lu Luo, Yong-Qi Liu, Yang Li, Chao Guo, Zhen-Dong Li, Xiao-Rong Xie, Hai-Xia Song, Li-Ping Yang, Shao-Bo Sun, Fang-Yu An
Cancer vaccines mostly aim to induce cytotoxic T lymphocytes (CTLs) against tumors. An appropriate adjuvant is of fundamental importance for inducing cellular immune response. Since the antigen in particulate form is substantially more immunogenic than soluble form antigen, it is beneficial to interact with antigen-presenting cells membrane to induce robust CD8+ T cell activation following vaccination. Based on previous research, we designed an adjuvant formulation by combining Astragalus saponins, cholesterol, and liposome to incorporate antigen into a particulate delivery system, so as to enhance cellular immune response...
February 2018: Cancer Biotherapy & Radiopharmaceuticals
Martin W Brechbiel
No abstract text is available yet for this article.
February 2018: Cancer Biotherapy & Radiopharmaceuticals
Sanjay Kumar Saxena, Yogendra Kumar, Samina H Shaikh, Usha Pandey, Sanjukta A Kumar, Ashutosh Dash
The primary objective of this investigation is the development of a strategy for the synthesis of polyhydroxamic acid (PHA)-grafted cellulose film, its characterization, and evaluation of its usefulness for the preparation of 177Lu skin patches for superficial brachytherapy applications. PHA-grafted cellulose films were synthesized and characterized by Fourier transformed infrared spectrometer analysis and visual color test with Fe(III) solution. Uptake of 177Lu on the PHA-grafted cellulose was investigated by varying the experimental conditions such as the pH of feed solution, amount of nonradioactive Lu carrier, time, and temperature of the reaction...
December 2017: Cancer Biotherapy & Radiopharmaceuticals
Zhibo Sun, Anjun Li, Zhihong Yu, Xiangwei Li, Xiao Guo, Rong Chen
BACKGROUND: Osteosarcoma (OS) is a frequent primary bone malignancy. MicroRNA-497-5p (miR-497-5p) has been recently reported to be downregulated in angiosarcoma, but its potential role in OS remains unclear. METHODS: Quantitative real-time polymerase chain reaction was used to determine miR-497-5p expression in OS tissues and cell lines. The effect of miR-497-5p on cell growth, cell cycle progression and apoptosis were measured using CCK-8 and flow cytometry assays, respectively...
December 2017: Cancer Biotherapy & Radiopharmaceuticals
Peishan Teo, Xiaowen Wang, Benke Chen, Han Zhang, Xin Yang, Yun Huang, Jintian Tang
BACKGROUND: Magnetic nanoparticles are increasingly applied in clinical area for drug delivery, also in magnetic induction hyperthermia (MIH), and so on. The present research would prepare appropriately modified superparamagnetic iron oxide nanoparticles (SPIONs) to conduct MIH and transfect the anticancer cytokine TNF-α into cells. MATERIALS AND METHODS: The SPIONs were surface-modified by 3-aminopropyltriethoxysilane (APTS) and/or protamine sulfate (PRO). The combined MIH using SPIONs and gene therapy were applied to treat Hep G2 cells and tumor model transplanted in nude mice...
December 2017: Cancer Biotherapy & Radiopharmaceuticals
Fabiana G Curea, Mohamed Hebbar, Silvia M Ilie, Xenia E Bacinschi, Oana G Trifanescu, Inga Botnariuc, Rodica M Anghel
Gastric cancer is one of the most common types of cancer in the world, usually diagnosed at an advanced stage. Despite the advances in specific anticancer agents' development, the survival rates remain modest, even in early stages. In 15%-20% of cases, the human epidermal growth factor receptor 2 (HER2) overexpression was identified. We conducted a general review to summarize the progress that has been made in the targeted treatment of HER2-positive esogastric junction or gastric adenocarcinoma. According to our findings, trastuzumab is the only validated anti-HER2 agent in locally advanced or metastatic disease and its adjuvant effectiveness is assessed in a RTOG phase III study...
December 2017: Cancer Biotherapy & Radiopharmaceuticals
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Cancer Biotherapy & Radiopharmaceuticals
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Cancer Biotherapy & Radiopharmaceuticals
Elena Vasilskis, Ingrid Kreimerman, Silvia Olivera, Eduardo Savio, Henry Engler
AIM: To compare the uptake of (11)C-deuterodeprenyl ((11)C-DED) and (11)C-methionine ((11)C-MET) in three human glioma cell lines and study the relationship with glial fibrillary acid protein (GFAP) and monoamine oxidase B (MAO B) expression. (11)C-DED is used in positron emission tomography imaging as a marker of astrocytosis in various central nervous system pathologies. It binds irreversibly to MAO B, a glial dimeric enzyme with increased activity in some neurological pathologies. MATERIALS AND METHODS: Binding and internalization studies of (11)C-MET and (11)C-DED were performed in astrocytoma grade III, glioblastoma grade IV, and radio-resistant glioblastoma grade IV cells...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
Jing Zheng, Huiling Li, Dongting Xu, Huijuan Zhu
Tyrosine kinase FYN-a member of the SRC family of kinases-is associated with mediating mitogenic signals and regulating cell cycle entry, growth, and proliferation. It was hypothesized that FYN is upregulated in thyroid carcinoma, which plays a critical role in tumorigenesis. FYN expression level in thyroid carcinoma tissue and tumor cell lines was determined. Also, the effects of FYN on thyroid cancer (TC) growth, signaling, cell cycle, and apoptosis were evaluated in vitro. FYN was knocked down in thyroid cancer cells (TPC-1) by siRNA to investigate the effects on cell proliferation, invasion, and migration...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
Linn Hagmarker, Johanna Svensson, Tobias Rydén, Peter Gjertsson, Peter Bernhardt
BACKGROUND: In (177)Lu-DOTATATE treatments, bone marrow (BM) is one of the most important organs at risk. The authors previously developed an image-based two-compartment method for BM dosimetry, showing a significant correlation between absorbed dose to BM and hematological toxicity in (177)Lu-DOTATATE treatments. In the present study, they aimed to further evaluate this BM dosimetry method by finding optimal settings for dividing the whole body into two compartments; in terms of minimizing the coefficient of variation (CV) for the individual absorbed doses and studying its correlation to the BM response...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
Xuejun Liu, Chuqin Zhang, Zhonghua Zhang, Zuping Zhang, Wei Ji, Shengda Cao, Xiaolan Cai, Dapeng Lei, Xinliang Pan
The E26 transformation-specific (ETS) family is one of the largest families of transcription factors. Upon activation by MAPK pathway, ETS participates in cell proliferation, differentiation, migration, apoptosis, and metastasis. However, the mechanism by which ETS is deregulated in cancer is unclear. In this study, the authors investigated the role of ETS factor, ETS2, in hypopharyngeal cancer pathogenesis in hypopharyngeal cancer tissues (N = 20) and corresponding non-neoplastic tissues (N = 20). The results showed that expression of ETS2 was increased in cancer tissues as compared with the expression in corresponding non-neoplastic tissues...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
Peter L Roberson, Lauren B Smith, Meredith A Morgan, Matthew J Schipper, Scott J Wilderman, Anca M Avram, Mark S Kaminski, Yuni K Dewaraja
INTRODUCTION: Non-Hodgkin Lymphoma patients respond differently to therapy according to inherent biological variations. Pretherapy biomarkers may improve dose-response prediction. MATERIALS AND METHODS: Hybrid single-photon emission computed tomography (SPECT)/computed tomography (CT) three-dimensional imaging at multiple time points plus follow-up positron emission tomography (PET)/CT or CT at 2 and 6 months post therapy were used to fit tumor response to combined biological effect and cell clearance models from which three biological effect response parameters (radiosensitivity, cold effect sensitivity, and proliferation potential) were determined per patient...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
Buddhi Prakash Jain
Secretory and transmembrane proteins undergo post-translational modifications and folding in the subcellular organelle, that is, endoplasmic reticulum (ER) to become functionally active. Various factors such as high oxidative stress, low glucose, calcium imbalance, and viral infections interfere with the ER protein folding functions, leading to accumulation of unfolded and misfolded proteins that activate downstream signal transduction pathways, termed as unfolded protein response (UPR). This UPR signaling is adaptive and restored the normal function of cells by decreasing protein synthesis, increasing the folding capacity of ER and degradation of misfolded proteins...
October 2017: Cancer Biotherapy & Radiopharmaceuticals
Yang Zhang, Jinyin Yan, Lu Wang, Hao Dai, Ning Li, Wanning Hu, Haifeng Cai
OBJECTIVE: Many malignant tumors grow in hypoxic condition, which is associated with tumor growth, invasion, and metastasis. MicroRNAs are of great significance in the development of multiple malignant tumors. This study cultured breast cancer cell MCF-7 under the condition of different concentrations of oxygen, to test cell proliferation and invasion, and detect miR-210 expression, aiming to analyze the influence of hypoxia on breast cancer cell behaviors as well as miR-210 expressions...
October 2017: Cancer Biotherapy & Radiopharmaceuticals
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