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Cancer Biotherapy & Radiopharmaceuticals

Mohini Guleria, Tapas Das, Jeyachitra Amirdhanayagam, Ajit S Shinto, Koramadai K Kamaleshwaran, Arun Pandian, Haladhar D Sarma, Ashutosh Dash
PURPOSE: 68 Ga-BPAMD has recently emerged as one of the preferred radiopharmaceuticals for imaging of bone lesions due to its ability to produce high-resolution images and uncomplicated availability of 68 Ga, a positron emission tomography (PET) radionuclide, from commercial 68 Ge/68 Ga generators. The primary objective of this work is to develop freeze-dried BPAMD kit, for the easy and convenient formulation of 68 Ga-BPAMD patient dose at the hospital radiopharmacy. In addition, the kit should be compatible with 68 Ga, eluted using HCl of various molarities from the 68 Ge/68 Ga generators sourced from different suppliers...
November 3, 2018: Cancer Biotherapy & Radiopharmaceuticals
Liuping Bao, Jianxin Zhong, Lijuan Pang
BACKGROUND: Circular RNAs (circRNAs) comprise a class of noncoding RNA molecules that play an important role in several normal cellular functions, as well as tumorigenesis in humans. However, the expression patterns and biological functions of circRNAs in ovarian cancer (OC) remain unclear. METHODS: Therefore, we investigated the expression profiles and biological functions of certain circRNAs in OC tumor tissues. The expression of three circRNAs (VPS13C-has-circ-001567, RAD50-has-circ-00718, and SPECC1-has-circ-000013) was detected by real-time polymerase chain reaction in OC cell lines, and also in tumor and pericarcinous tissues obtained from 20 patients with OC...
October 30, 2018: Cancer Biotherapy & Radiopharmaceuticals
Abigail E Besemer, Joseph J Grudzinski, Jamey P Weichert, Lance T Hall, Bryan P Bednarz
INTRODUCTION: CLR1404 is a theranostic molecular agent that can be radiolabeled with 124 I (CLR 124) for positron emission tomography (PET) imaging, or 131 I (CLR 131) for single-photon emission computed tomography (SPECT) imaging and targeted radionuclide therapy. This pilot study evaluated a pretreatment dosimetry methodology in a triple-negative breast cancer patient who was uniquely enrolled in both a CLR 124 PET imaging clinical trial and a CLR 131 therapeutic dose escalation clinical trial...
October 23, 2018: Cancer Biotherapy & Radiopharmaceuticals
Charu Bahl, Navneet Singh, Digambar Behera, Siddharth Sharma
BACKGROUND: To investigate the prognostic implication of genetic variants within the wingless (Wnt) antagonist genes (DKK, sFRP, and Axin2) in North Indian lung cancer patients. MATERIALS AND METHODS: A total of 212 subjects were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique for 18 polymorphic sites in DKK4, DKK3, DKK2, sFRP3, sFRP4, and Axin2. Overall survival (OS) was estimated using the Kaplan-Meier survival analysis, and adjusted hazard ratio (HR) was obtained using the Cox regression method...
October 20, 2018: Cancer Biotherapy & Radiopharmaceuticals
Manoj Kumar, Usha Pandey, Yugandhara Yadav, Shyamala S Gandhi, Sanjay Kumar Saxena, Yogendra Kumar, Jitendra Nuwad, Ashutosh Dash
OBJECTIVE: This article describes the preparation of a 170 Tm source by chemical deposition technique, its encapsulation in a titanium holder, and preliminary quality evaluation for potential utility as a brachytherapy source. METHODS: The procedure consisted of electrodeposition of Ni on a Cu wire followed by chemical deposition of 170 Tm on it. Influence of feed solution pH, carrier Tm concentration, and reaction time were studied for optimum deposition of 170 Tm on substrate...
October 2, 2018: Cancer Biotherapy & Radiopharmaceuticals
Sandrine Huclier-Markai, Cyrille Alliot, Rabha Kerdjoudj, Marie Mougin-Degraef, Nicolas Chouin, Ferid Haddad
Scandium radionuclides have been identified in the late 1990s as promising for nuclear medicine applications, but have been set aside for about 20 years. Among the different isotopes of scandium, 43 Sc and 44 Sc are interesting for positron emission tomography imaging, whereas 47 Sc is interesting for therapy. The 44 Sc/47 Sc or 43 Sc/47 Sc pairs could be thus envisaged as true theranostic pairs. Another interesting aspect of scandium is that its chemistry is governed by the trivalent ion, Sc3+ . When combined with its hardness and its size, it gives this element a lanthanide-like behavior...
September 28, 2018: Cancer Biotherapy & Radiopharmaceuticals
Li-Juan Zhang, Xue-Qin Li, Cun-De Wang, Li Zhuang, Quan Gong, Shi-Juan Li, Xin Liu, Hui Dong, Xi-Cai Wang
OBJECTIVE: To investigate the protein expression of visfatin and its gene polymorphism in non-small cell lung cancer (NSCLC) patients. METHODS: The plasma level of visfatin was detected by enzyme-linked immunosorbent assay, and the genotypes rs59744560, rs9770242, and rs61330082 in the visfatin gene were detected by gene sequencing. RESULT: This study revealed that plasma levels of visfatin in NSCLC patients were significantly higher than the levels in healthy people (p < 0...
September 26, 2018: Cancer Biotherapy & Radiopharmaceuticals
Sedigheh Rezaeianpour, Mona Mosayebnia, Abolghasem Moghimi, Salimeh Amidi, Parham Geramifar, Farzad Kobarfard, Soraya Shahhosseini
PURPOSE: Fibrin is a perfect target for specific imaging of all types of thrombotic lesions. Cyclic peptides were introduced as the best scaffolds out of the different types of probes for thrombi detection. This study was conducted to label previously synthesized peptide-targeting fibrin with [18 F]FDG and its in vitro and in vivo assessments. MATERIALS AND METHODS: CGPRPPC peptide functionalized with 6-hydrazinonicotinamide and Eei-NHS was synthesized and cyclized using air oxidation method...
September 20, 2018: Cancer Biotherapy & Radiopharmaceuticals
Martin W Brechbiel
No abstract text is available yet for this article.
September 15, 2018: Cancer Biotherapy & Radiopharmaceuticals
Mahsa Salehi, Mohammadreza Sharifi, Marzieh Bagheri
OBJECTIVE: Acute erythroleukemia (AEL) is a subtype of acute myeloid leukemia (AML), with no specific treatment. Up- or downregulation of long noncoding RNAs (lncRNAs) is strongly associated with the formation and progression of many malignancies. Plasmacytoma variant translocation 1 (PVT1) is a significantly upregulated lncRNA in AML. Antisense locked nucleic acid (LNA) GapmeRs oligonucleotides are the novel tools for targeting lncRNAs. The purpose of the current study was to investigate the functional role of PVT1 antisense LNA GapmeRs on AEL cell line (KG-1)...
August 24, 2018: Cancer Biotherapy & Radiopharmaceuticals
Guanglei Fan, Renming Wan, Bin Zhang, Shengming Deng, Mingya Peng, Weihong Xue, Longbao Xu, Xihu Qin, Yiwei Wu
BACKGROUND: To study the distribution and imaging of 99m Tc-nGO-PEG-FA in human pancreatic cancer Patu8988 tumor-bearing nude mice, and to explore its usefulness as an imaging reagent for pancreatic cancer. MATERIALS AND METHODS: Natural graphite powder was used as raw material to prepare the nanosized graphene oxide (nGO) by using the modified Hummers method, and then was covalently modified by polyethylene glycol (PEG) on the surface of nGO. The nGO was further optimized by in vitro cell experiment, and then conjugated with the targeting molecule folic acid (FA) to form nGO-PEG-FA system...
August 22, 2018: Cancer Biotherapy & Radiopharmaceuticals
Farideh Hosseini, Mohammad Reza Sam, Nasrollah Jabbari, Hossein Mozdarani
Mutant-p53 colorectal cancer (CRC) cells are often resistant to radiotherapy. Loss of suppressor activity of wt-p53 on survivin is responsible for the enhanced expression of survivin as a radioresistant factor in tumor cells. Yet, no survivin-modulating drug has been approved for clinical application in CRC. Thus, the search for safe compounds that modulate survivin expression and induce apoptosis irrespective of p53 status may potentiate the efficacy of radiotherapy in mutant-p53 CRC cells. Omega-3 docosahexaenoic acid (DHA) induces apoptosis in malignant cells without cytotoxicity in normal cells...
November 2018: Cancer Biotherapy & Radiopharmaceuticals
Yan Liang, Hesheng Luo, Haidong Zhang, Youhong Dong, Ying Bao
PURPOSE: To determine the expression and function of Delta/Notch-like EGF-related receptor (DNER) in hepatocellular carcinoma (HCC). METHODS: The expression of DNER in 84 HCC tissue samples and matched adjacent noncancerous specimens, as well as HCC cells, were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. Survival analysis was evaluated using Kaplan-Meier method. For experiments in vitro, cell viability was measured by Cell Counting Kit-8 Assay and Colony Formation Assay...
November 2018: Cancer Biotherapy & Radiopharmaceuticals
Yoo Sung Song, Joong Hyun Kim, Byung Chul Lee, Jae Ho Jung, Hyun Soo Park, Sang Eun Kim
BACKGROUND: Integrin αv β3 is a molecular marker for the estimation of tumor angiogenesis. 99m Tc-IDA-D-[c(RGDfK)]2 (also known as BIK-505) is a recently developed radiotracer for single-photon emission computed tomography, with good affinity for integrin αv β3 . In this study, the authors investigated the whole-body distribution and internal radiation dosimetry of 99m Tc-IDA-D-[c(RGDfK)]2 in elderly human participants. MATERIALS AND METHODS: Six healthy volunteers underwent whole-body simultaneous anterior and posterior scans, preceded by transmission scans using cobalt-57 flood source, with a dual head gamma camera system, at 0, 1, 2, 4, 8, and 24 h postinjection of 99m Tc-IDA-D-[c(RGDfK)]2 (injected radioactivity [mean ± SD] = 388...
November 2018: Cancer Biotherapy & Radiopharmaceuticals
Zhihui Hong, Xinping Mao, Jiaxi You, Zengli Liu, Yizhen Shi
PURPOSE: Overexpression of the HER2/neu (HER2) is linked to an adverse outcome in ovarian cancer. Short-interfering RNA (siRNA) is a HER2 inhibitor, which in combination with chemotherapy improves survival rate. The aim of this study was to evaluate the efficacy of adenovirus mediated HER2-siRNA in combination with cisplatin (Ad-HER2-siRNA+DDP) on treating HER2-positive ovarian cancer xenografts and explore the effectiveness of 131 I-Herceptin immunoSPECT imaging for monitoring the tumor's progression...
November 2018: Cancer Biotherapy & Radiopharmaceuticals
Fereshteh Hallajian, Maryam Ghasmi, Seyed Mohammad Abedi, Ramezan Behzadi, Effat Hayati, Nourollah Sadeghzadeh, Farzaneh Rezazadeh, Hanieh Karimi
BACKGROUND AND OBJECTIVE: Doxorubicin (DOX), despite having antitumor properties, also exhibits cardiotoxicity. Resveratrol has antitumor property for breast cancer cells. 99m Tc-MIBI has higher absorption rate in human breast cancer cell line MCF-7. In the present study, the authors intend to investigate the effect of DOX and resveratrol on the absorption of 99m Tc-MIBI in breast cancer cell xenografts in mice. MATERIALS AND METHODS: Sixteen xenograft models in nude mice were divided into four groups...
November 2018: Cancer Biotherapy & Radiopharmaceuticals
Bo Xu, Jia Liu, Xin Xiang, Shunhai Liu, Pingyong Zhong, Fei Xie, Tinggang Mou, Liang Lai
OBJECTIVE: To analyze the expression of micro-RNA 143 (miRNA-143) in the patients with pancreatic cancer and to explore the influence of overexpression of miRNA-143 on pancreatic cancer cells. METHODS: Twenty-five patients with pancreatic cancer that received treatment in their hospital were included in this study. Pancreatic cancer tissues of the patients were surgically removed, and cancer-adjacent tissues were taken for control. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expressions of miRNA-143 and its target gene Kirsten rat sarcoma (KRAS) in pancreatic cancer tissues and cancer-adjacent tissues...
November 2018: Cancer Biotherapy & Radiopharmaceuticals
Yiqi Deng, Feng Zhao, Zhenhua Zhang, Fujie Sun, Mingxing Wang
The long noncoding RNA (LncRNA) SNHG7 (small nuclear RNA host gene 7) is a novel LncRNA and functions as an oncogene to promote tumor proliferation and inhibits apoptosis in many cancers. However, the role of SNHG7 in osteosarcoma (OS) remains to be further investigated. In this study, OS tissues and corresponding relative normal tissues (n = 30) were collected to determine the expression of SNHG7 in OS. The results indicated that high SNHG7 level in OS correlated with high Enneking stage, distant metastasis, and short overall survival time of OS patients...
November 2018: Cancer Biotherapy & Radiopharmaceuticals
Muath Helal, Ekaterina Dadachova
In the past several decades, many antimicrobial agents have been used in treating different fungal, bacterial, and viral infections. However, these agents have faced challenges such as pronounced side-effect profiles and pathogen resistance. In addition, a cure for many chronic infections such as human immunodeficiency virus (HIV) has not been achieved, and the incidence of opportunistic infections in immunocompromised patients has increased significantly in the past decades. Therefore, an alternative strategy for combating these infections is needed...
October 2018: Cancer Biotherapy & Radiopharmaceuticals
Kevin J H Allen, Rubin Jiao, Mackenzie E Malo, Ekaterina Dadachova
Radioimmunotherapy offers an effective way to direct ionizing radiation to cancer cells through attachment of radionuclides to antibodies while limiting negative effects of off-target irradiation. This, however, requires effective facile methods for attachment of therapeutic radionuclides onto antibodies. Herein, the authors report their efforts in evaluating N-succinimidyl S-acetylthioacetate (SATA), a commercially available reagent, for use as a bifunctional chelating agent (BCA) to attach 188 Rhenium (188 Re) onto h8C3, a humanized IgG antibody that can effectively target extracellular melanin present in malignant melanoma...
October 2018: Cancer Biotherapy & Radiopharmaceuticals
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