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Cancer Biotherapy & Radiopharmaceuticals

Yan Liang, Hesheng Luo, Haidong Zhang, Youhong Dong, Ying Bao
PURPOSE: To determine the expression and function of Delta/Notch-like EGF-related receptor (DNER) in hepatocellular carcinoma (HCC). METHODS: The expression of DNER in 84 HCC tissue samples and matched adjacent noncancerous specimens, as well as HCC cells, were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. Survival analysis was evaluated using Kaplan-Meier method. For experiments in vitro, cell viability was measured by Cell Counting Kit-8 Assay and Colony Formation Assay...
September 20, 2018: Cancer Biotherapy & Radiopharmaceuticals
Sedigheh Rezaeianpour, Mona Mosayebnia, Abolghasem Moghimi, Salimeh Amidi, Parham Geramifar, Farzad Kobarfard, Soraya Shahhosseini
PURPOSE: Fibrin is a perfect target for specific imaging of all types of thrombotic lesions. Cyclic peptides were introduced as the best scaffolds out of the different types of probes for thrombi detection. This study was conducted to label previously synthesized peptide-targeting fibrin with [18 F]FDG and its in vitro and in vivo assessments. MATERIALS AND METHODS: CGPRPPC peptide functionalized with 6-hydrazinonicotinamide and Eei-NHS was synthesized and cyclized using air oxidation method...
September 20, 2018: Cancer Biotherapy & Radiopharmaceuticals
Martin W Brechbiel
No abstract text is available yet for this article.
September 15, 2018: Cancer Biotherapy & Radiopharmaceuticals
Mahsa Salehi, Mohammadreza Sharifi, Marzieh Bagheri
OBJECTIVE: Acute erythroleukemia (AEL) is a subtype of acute myeloid leukemia (AML), with no specific treatment. Up- or downregulation of long noncoding RNAs (lncRNAs) is strongly associated with the formation and progression of many malignancies. Plasmacytoma variant translocation 1 (PVT1) is a significantly upregulated lncRNA in AML. Antisense locked nucleic acid (LNA) GapmeRs oligonucleotides are the novel tools for targeting lncRNAs. The purpose of the current study was to investigate the functional role of PVT1 antisense LNA GapmeRs on AEL cell line (KG-1)...
August 24, 2018: Cancer Biotherapy & Radiopharmaceuticals
Yoo Sung Song, Joong Hyun Kim, Byung Chul Lee, Jae Ho Jung, Hyun Soo Park, Sang Eun Kim
BACKGROUND: Integrin αv β3 is a molecular marker for the estimation of tumor angiogenesis. 99m Tc-IDA-D-[c(RGDfK)]2 (also known as BIK-505) is a recently developed radiotracer for single-photon emission computed tomography, with good affinity for integrin αv β3 . In this study, the authors investigated the whole-body distribution and internal radiation dosimetry of 99m Tc-IDA-D-[c(RGDfK)]2 in elderly human participants. MATERIALS AND METHODS: Six healthy volunteers underwent whole-body simultaneous anterior and posterior scans, preceded by transmission scans using cobalt-57 flood source, with a dual head gamma camera system, at 0, 1, 2, 4, 8, and 24 h postinjection of 99m Tc-IDA-D-[c(RGDfK)]2 (injected radioactivity [mean ± SD] = 388...
August 22, 2018: Cancer Biotherapy & Radiopharmaceuticals
Guanglei Fan, Renming Wan, Bin Zhang, Shengming Deng, Mingya Peng, Weihong Xue, Longbao Xu, Xihu Qin, Yiwei Wu
BACKGROUND: To study the distribution and imaging of 99m Tc-nGO-PEG-FA in human pancreatic cancer Patu8988 tumor-bearing nude mice, and to explore its usefulness as an imaging reagent for pancreatic cancer. MATERIALS AND METHODS: Natural graphite powder was used as raw material to prepare the nanosized graphene oxide (nGO) by using the modified Hummers method, and then was covalently modified by polyethylene glycol (PEG) on the surface of nGO. The nGO was further optimized by in vitro cell experiment, and then conjugated with the targeting molecule folic acid (FA) to form nGO-PEG-FA system...
August 22, 2018: Cancer Biotherapy & Radiopharmaceuticals
Muath Helal, Ekaterina Dadachova
In the past several decades, many antimicrobial agents have been used in treating different fungal, bacterial, and viral infections. However, these agents have faced challenges such as pronounced side-effect profiles and pathogen resistance. In addition, a cure for many chronic infections such as human immunodeficiency virus (HIV) has not been achieved, and the incidence of opportunistic infections in immunocompromised patients has increased significantly in the past decades. Therefore, an alternative strategy for combating these infections is needed...
August 22, 2018: Cancer Biotherapy & Radiopharmaceuticals
Ali Younes, Cyrille Alliot, Marcel Mokili, Gilles Montavon
Anthropogenic radioactivity generated by nuclear or chemical events results in the liberation of quadrillions of Becquerel and tons of materials to the environment. These events include nuclear accidents, nuclear weapon experiments, and high levels of generated radioactive and chemical waste. 210 Po is a high-energy α emitter that presents in the environment at extremely low concentration. It is considered as one of the highly toxic elements and is estimated to contribute about 7% of the total effective dose equivalent to humans from ingested natural internal radiation...
August 8, 2018: Cancer Biotherapy & Radiopharmaceuticals
Zhihui Hong, Xinping Mao, Jiaxi You, Zengli Liu, Yizhen Shi
PURPOSE: Overexpression of the HER2/neu (HER2) is linked to an adverse outcome in ovarian cancer. Short-interfering RNA (siRNA) is a HER2 inhibitor, which in combination with chemotherapy improves survival rate. The aim of this study was to evaluate the efficacy of adenovirus mediated HER2-siRNA in combination with cisplatin (Ad-HER2-siRNA+DDP) on treating HER2-positive ovarian cancer xenografts and explore the effectiveness of 131 I-Herceptin immunoSPECT imaging for monitoring the tumor's progression...
July 27, 2018: Cancer Biotherapy & Radiopharmaceuticals
Fereshteh Hallajian, Maryam Ghasmi, Seyed Mohammad Abedi, Ramezan Behzadi, Effat Hayati, Nourollah Sadeghzadeh, Farzaneh Rezazadeh, Hanieh Karimi
BACKGROUND AND OBJECTIVE: Doxorubicin (DOX), despite having antitumor properties, also exhibits cardiotoxicity. Resveratrol has antitumor property for breast cancer cells. 99m Tc-MIBI has higher absorption rate in human breast cancer cell line MCF-7. In the present study, the authors intend to investigate the effect of DOX and resveratrol on the absorption of 99m Tc-MIBI in breast cancer cell xenografts in mice. MATERIALS AND METHODS: Sixteen xenograft models in nude mice were divided into four groups...
July 24, 2018: Cancer Biotherapy & Radiopharmaceuticals
Kevin J H Allen, Rubin Jiao, Mackenzie E Malo, Ekaterina Dadachova
Radioimmunotherapy offers an effective way to direct ionizing radiation to cancer cells through attachment of radionuclides to antibodies while limiting negative effects of off-target irradiation. This, however, requires effective facile methods for attachment of therapeutic radionuclides onto antibodies. Herein, the authors report their efforts in evaluating N-succinimidyl S-acetylthioacetate (SATA), a commercially available reagent, for use as a bifunctional chelating agent (BCA) to attach 188 Rhenium (188 Re) onto h8C3, a humanized IgG antibody that can effectively target extracellular melanin present in malignant melanoma...
July 16, 2018: Cancer Biotherapy & Radiopharmaceuticals
Shin Hye Ahn, Eszter Boros
New, targeted imaging tracers enable improved diagnosis, staging, and planning of treatment of disease and represent an important step toward personalized medicine applications. The combination of radioisotopes for nuclear imaging with fluorophores for fluorescence imaging provides the possibility to noninvasively assess disease burden in a patient using positron emission tomography/single-photon emission computed tomography, followed by fluorescence imaging-assisted surgical intervention in close succession...
July 13, 2018: Cancer Biotherapy & Radiopharmaceuticals
Bo Xu, Jia Liu, Xin Xiang, Shunhai Liu, Pingyong Zhong, Fei Xie, Tinggang Mou, Liang Lai
OBJECTIVE: To analyze the expression of micro-RNA 143 (miRNA-143) in the patients with pancreatic cancer and to explore the influence of overexpression of miRNA-143 on pancreatic cancer cells. METHODS: Twenty-five patients with pancreatic cancer that received treatment in their hospital were included in this study. Pancreatic cancer tissues of the patients were surgically removed, and cancer-adjacent tissues were taken for control. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expressions of miRNA-143 and its target gene Kirsten rat sarcoma (KRAS) in pancreatic cancer tissues and cancer-adjacent tissues...
July 13, 2018: Cancer Biotherapy & Radiopharmaceuticals
Yiqi Deng, Feng Zhao, Zhenhua Zhang, Fujie Sun, Mingxing Wang
The long noncoding RNA (LncRNA) SNHG7 (small nuclear RNA host gene 7) is a novel LncRNA and functions as an oncogene to promote tumor proliferation and inhibits apoptosis in many cancers. However, the role of SNHG7 in osteosarcoma (OS) remains to be further investigated. In this study, OS tissues and corresponding relative normal tissues (n = 30) were collected to determine the expression of SNHG7 in OS. The results indicated that high SNHG7 level in OS correlated with high Enneking stage, distant metastasis, and short overall survival time of OS patients...
July 10, 2018: Cancer Biotherapy & Radiopharmaceuticals
Min Wang, Fang Yuan, Yi Wei, Chunchao Xia, Fubi Hu, Bin Song
INTRODUCTION: It is urgent to find an effective method to diagnose and prognose early hepatocellular carcinoma (HCC). The purpose of this study was to investigate the correlation between HCC histological degree and water percentage (WP) obtained from magnetic resonance imaging 3D-VIBE multiecho Dixon, and to evaluate the feasibility of WP in the postoperative prediction of early HCC recurrence. METHODS AND MATERIALS: From June 2016 to July 2017, 76 patients with diagnostic HCC all underwent 3D-VIBE Multiecho Dixon and ultrahigh b value diffusion-weighted imaging (DWI) examination...
September 2018: Cancer Biotherapy & Radiopharmaceuticals
Milad Sabzevary-Ghahfarokhi, Hedayatollah Shirzad, Mahmoud Rafieian-Kopaei, Mahdi Ghatreh-Samani, Mojtaba Shohan
Secreted inflammatory cytokines are considered as critical mediators in the tumor microenvironment. Cancer cells play a significant role in the differentiation of effector T cells to exhausted T cells through mediator production. Effector T cells that undergo tumor microenvironment become terminally differentiated into exhausted T cells. These changes create an opportunity for tumorigenesis and invasion of cancer cells. Despite having some characteristics of effector T cells, the exhausted T cells lose their antitumor properties...
September 2018: Cancer Biotherapy & Radiopharmaceuticals
Aixia Sun, Xiaolan Tang, Dahong Nie, Yixiang Fan, Ganghua Tang
OBJECTIVES: As acid-base imbalance is involved in many pathological processes, the capability to image tissue pH alterations in the clinic could offer new ways to detect disease and respond to treatment. In this study, the authors show that tissue pH can be imaged in vivo with 11 C-labeled bicarbonate (H11 CO3 - ) buffer and positron emission tomography (PET). METHODS: H11 CO3 - was produced by on-column NaOH adsorption. Biodistribution of H11 CO3 - in normal mice was determined...
September 2018: Cancer Biotherapy & Radiopharmaceuticals
Murali Kesavan, J Harvey Turner, Danielle Meyrick, Sharon Yeo, Giuseppe Cardaci, Nat P Lenzo
BACKGROUND: Prostate-specific membrane antigen (PSMA)-based radiopeptide/radioligand therapy represents a rapidly expanding field in the management of metastatic castrate-resistant prostate cancer (mCRPC). However, there remains concern for the development of significant toxicities in heavily pretreated patients. In this study, the authors present their local experience, with respect to efficacy and toxicity, of 22 consecutive patients treated with lutetium-177-DOTAGA-(I-y)fk(Sub-KuE) or 177 Lu-PSMA I&T radioimmunotherapy for progressive mCRPC, followed up over 1 year...
September 2018: Cancer Biotherapy & Radiopharmaceuticals
Jinshan Zhang, Yuan Li, Ge Wen, Yongmei Deng, Hongxia Yao
BACKGROUND: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a distinctive benign vascular disease that can be challenging to treat due to inconsistent results for various treatment modalities such as surgical excision, corticosteroids, radiotherapy, laser therapy, and other therapies, so novel approaches are needed to improve treatment outcomes. MATERIALS AND METHODS: ALHE on the right auricle of a 54-year-old Chinese woman underwent brachytherapy using 32 P simple drug membranes for five times...
September 2018: Cancer Biotherapy & Radiopharmaceuticals
Mine Araz, Derya Cayir, Bekir Ucan, Alper Dilli, Erman Çakal
OBJECTIVE: (1)To define a quantitative cutoff value for incidental pituitary Technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) uptake above which is of clinical importance and (2) to investigate possible factors affecting the intensity of uptake in pituitary adenoma. MATERIALS AND METHODS: A retrospective analysis of 55 patients with a simultaneous parathyroid single-photon emission computed tomography and pituitary magnetic resonance imaging were included...
September 2018: Cancer Biotherapy & Radiopharmaceuticals
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