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Addiction Biology

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https://www.readbyqxmd.com/read/29044937/selective-inhibition-of-m5-muscarinic-acetylcholine-receptors-attenuates-cocaine-self-administration-in-rats
#1
Barak W Gunter, Robert W Gould, Michael Bubser, Kevin M McGowan, Craig W Lindsley, Carrie K Jones
Cocaine use disorder (CUD) remains a debilitating health problem in the United States for which there are no Food and Drug Administration-approved treatment options. Accumulating anatomical and electrophysiological evidence indicates that the muscarinic acetylcholine receptor (mAChR) subtype 5 (M5 ) plays a critical role in the regulation of the mesolimbic dopaminergic reward circuitry, a major site of action for cocaine and other psychostimulants. In addition, M5 knockout mice exhibit reduced cocaine self-administration behaviors with no differences in sugar pellet-maintained responding relative to wild-type mice...
October 18, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29044813/activated-mesenchymal-stem-cell-administration-inhibits-chronic-alcohol-drinking-and-suppresses-relapse-like-drinking-in-high-alcohol-drinker-rats
#2
Fernando Ezquer, María Elena Quintanilla, Paola Morales, Marcelo Ezquer, Carolyne Lespay-Rebolledo, Mario Herrera-Marschitz, Yedy Israel
Neuroinflammation has been reported to follow chronic ethanol intake and may perpetuate alcohol consumption. Present studies determined the effect of human mesenchymal stem cells (hMSCs), known for their anti-inflammatory action, on chronic ethanol intake and relapse-like ethanol intake in a post-deprivation condition. Rats were allowed 12-17 weeks of chronic voluntary ethanol (10% and 20% v/v) intake, after which a single dose of activated hMSCs (5 × 10(5) ) was injected into a brain lateral ventricle...
October 18, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28971565/hypocretin-receptor-1-knockdown-in-the-ventral-tegmental-area-attenuates-mesolimbic-dopamine-signaling-and-reduces-motivation-for-cocaine
#3
David L Bernstein, Preeti S Badve, Jessica R Barson, Caroline E Bass, Rodrigo A España
The hypocretin receptor 1 (HCRTr1) is a critical participant in the regulation of motivated behavior. Previous observations demonstrate that acute pharmacological blockade of HCRTr1 disrupts dopamine (DA) signaling and the motivation for cocaine when delivered systemically or directly into the ventral tegmental area (VTA). To further examine the involvement of HCRTr1 in regulating reward and reinforcement processing, we employed an adeno-associated virus to express a short hairpin RNA designed to knock down HCRTr1...
October 2, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28961365/minocycline-increases-firing-rates-of-accumbal-neurons-and-modifies-the-effects-of-morphine-on-neuronal-activity
#4
Reza Arezoomandan, Esmail Riahi, Abbas Haghparast
Accumulating evidence indicated that minocycline, a glial cell modulator, is able to modify a variety of morphine effects. Here, we investigated minocycline effects on electrical activity of nucleus accumbens (NAc) neurons using single unit recording in urethane-anesthetized rats. In addition, we investigated whether minocycline can modify the effects of morphine on NAc neural activity during reinstatement of morphine-seeking behavior. Minocycline increased the NAc firing activity in intact animals. Electrophysiological recording in morphine-treated animals was performed, following the acquisition of morphine-induced conditioned place preference (5 mg/kg, s...
September 29, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28960802/functional-role-for-suppression-of-the-insular-striatal-circuit-in-modulating-interoceptive-effects-of-alcohol
#5
Anel A Jaramillo, Verda E Agan, Viren H Makhijani, Stephen Pedroza, Zoe A McElligott, Joyce Besheer
The insular cortex (IC) is a region proposed to modulate, in part, interoceptive states and motivated behavior. Interestingly, IC dysfunction and deficits in interoceptive processing are often found among individuals with substance-use disorders. Furthermore, the IC projects to the nucleus accumbens core (AcbC), a region known to modulate the discriminative stimulus/interoceptive effects of alcohol and other drug-related behaviors. Therefore, the goal of the present work was to investigate the possible role of the IC ➔ AcbC circuit in modulating the interoceptive effects of alcohol...
September 27, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28944558/imaging-the-neuroimmune-response-to-alcohol-exposure-in-adolescent-baboons-a-tspo-pet-study-using-18-f-dpa-714
#6
Wadad Saba, Sébastien Goutal, Sylvain Auvity, Bertrand Kuhnast, Christine Coulon, Virginie Kouyoumdjian, Irène Buvat, Claire Leroy, Nicolas Tournier
The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using translocator protein 18 kDa (TSPO) PET imaging, a non-invasive marker of glial activation, in adolescent baboons. Three different alcohol-naive adolescent baboons (3-4 years old, 9 to 14 kg) underwent (18) F-DPA-714 PET experiments before, during and 7-12 months after this initial alcohol exposure (0...
September 25, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28944554/limited-potential-of-cebranopadol-to-produce-opioid-type-physical-dependence-in-rodents
#7
Thomas M Tzschentke, Babette Y Kögel, Stefanie Frosch, Klaus Linz
Cebranopadol is a novel potent analgesic agonist at the nociceptin/orphanin FQ peptide (NOP) and classical opioid receptors. As NOP receptor activation has been shown to reduce side effects related to the activation of μ-opioid peptide (MOP) receptors, the present study evaluated opioid-type physical dependence produced by cebranopadol in mice and rats. In a naloxone-precipitated withdrawal assay in mice, a regimen of seven escalating doses of cebranopadol over 2 days produced only very limited physical dependence as evidenced by very little withdrawal symptoms (jumping) even at cebranopadol doses clearly exceeding the analgesic dose range...
September 25, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28940989/amino-acid-modulation-of-dopamine-in-the-nucleus-accumbens-mediates-sex-differences-in-nicotine-withdrawal
#8
Luis M Carcoba, Rodolfo J Flores, Luis A Natividad, Laura E O'Dell
The aversive effect of nicotine withdrawal is greater in female versus male rats, and we postulate that this sex difference is mediated in the nucleus accumbens (NAc). Nicotine withdrawal induces decreases in NAc dopamine and increases in acetylcholine (ACh) levels in male rats. To our knowledge, these neurochemical markers of nicotine withdrawal have not been compared in female versus male rats. Given the role of amino acids in modulating NAc dopaminergic and cholinergic transmission, concomitant measures of gamma-aminobutyric acid (GABA) and glutamate levels were also compared across sex...
September 22, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28940880/red-bull%C3%A2-energy-drink-increases-consumption-of-higher-concentrations-of-alcohol
#9
Marta Roldán, Victor Echeverry-Alzate, Kora-Mareen Bühler, Israel J Sánchez-Diez, Javier Calleja-Conde, Pedro Olmos, Stephen L Boehm, Rafael Maldonado, Fernando Rodríguez de Fonseca, Catalina Santiago, Felix Gómez-Gallego, Elena Giné, Jose Antonio López-Moreno
Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caffeine). Here, we have characterized how Red Bull®, one of the most consumed caffeinated energy drink worldwide, modulates operant alcohol self-administration in Wistar rats. We found that animals readily and steadily responded for Red Bull (mean: 90 responses, 30 minutes and fixed-ratio 1), which was accompanied by locomotor stimulating effects (26 percent increase)...
September 22, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28940879/phosphorylation-of-calcium-calmodulin-dependent-protein-kinase-ii-in-the-rat-dorsal-medial-prefrontal-cortex-is-associated-with-alcohol-induced-cognitive-inflexibility
#10
Luis A Natividad, Michael Q Steinman, Sarah A Laredo, Cristina Irimia, Ilham Y Polis, Robert Lintz, Matthew W Buczynski, Rémi Martin-Fardon, Marisa Roberto, Loren H Parsons
Repeated cycles of alcohol [ethanol (EtOH)] intoxication and withdrawal dysregulate excitatory glutamatergic systems in the brain and induce neuroadaptations in the medial prefrontal cortex (mPFC) that contribute to cognitive dysfunction. The mPFC is composed of subdivisions that are functionally distinct, with dorsal regions facilitating drug-cue associations and ventral regions modulating new learning in the absence of drug. A key modulator of glutamatergic activity is the holoenzyme calcium/calmodulin-dependent protein kinase II (CaMKII) that phosphorylates ionotropic glutamate receptors...
September 22, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28940758/time-dependent-neuronal-changes-associated-with-craving-in-opioid-dependence-an-fmri-study
#11
Anna Murphy, Dan I Lubman, Shane McKie, Prun S Bijral, Lesley A Peters, Qasim Faiz, Sophie E Holmes, Ian M Anderson, Bill Deakin, Rebecca Elliott
Relapse after initially successful treatment is a significant problem facing the treatment of opioid dependence. Evidence suggests craving elicited by re-exposure to drug cues may precipitate relapse. Attempts to identify neural biomarkers of cue-elicited craving have yielded inconsistent findings. We aimed to apply a novel continuous functional magnetic resonance imaging technique to follow the minute-to-minute evolution of brain responses, which correlate with the waxing and waning of craving. Newly detoxified male opioid-dependent patients and healthy control participants attended two separate, counterbalanced, functional magnetic resonance imaging scanning sessions during which they viewed a 10-minute video (drug cue or neutral cue) followed by 5 minutes of fixation...
September 22, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28940732/association-of-contextual-cues-with-morphine-reward-increases-neural-and-synaptic-plasticity-in-the-ventral-hippocampus-of-rats
#12
Mina Sadighi Alvandi, Maria Bourmpoula, Judith R Homberg, Yaghoub Fathollahi
Drug addiction is associated with aberrant memory and permanent functional changes in neural circuits. It is known that exposure to drugs like morphine is associated with positive emotional states and reward-related memory. However, the underlying mechanisms in terms of neural plasticity in the ventral hippocampus, a region involved in associative memory and emotional behaviors, are not fully understood. Therefore, we measured adult neurogenesis, dendritic spine density and brain-derived neurotrophic factor (BDNF) and TrkB mRNA expression as parameters for synaptic plasticity in the ventral hippocampus...
September 22, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28901722/%C3%AE-6-subunit-containing-nicotinic-receptors-mediate-low-dose-ethanol-effects-on-ventral-tegmental-area-neurons-and-ethanol-reward
#13
Scott C Steffensen, Samuel I Shin, Ashley C Nelson, Stephanie S Pistorius, Stephanie B Williams, Taylor J Woodward, Hyun Jung Park, Lindsey Friend, Ming Gao, Fenfei Gao, Devin H Taylor, M Foster Olive, Jeffrey G Edwards, Sterling N Sudweeks, Lori M Buhlman, J Michael McIntosh, Jie Wu
Dopamine (DA) neuron excitability is regulated by inhibitory GABAergic synaptic transmission and modulated by nicotinic acetylcholine receptors (nAChRs). The aim of this study was to evaluate the role of α6 subunit-containing nAChRs (α6*-nAChRs) in acute ethanol effects on ventral tegmental area (VTA) GABA and DA neurons. α6*-nAChRs were visualized on GABA terminals on VTA GABA neurons, and α6*-nAChR transcripts were expressed in most DA neurons, but only a minority of VTA GABA neurons from GAD67 GFP mice...
September 13, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28884950/abnormal-gray-matter-volume-and-impulsivity-in-young-adults-with-internet-gaming-disorder
#14
Deokjong Lee, Kee Namkoong, Junghan Lee, Young-Chul Jung
Reduced executive control is one of the central components of model on the development and maintenance of Internet gaming disorder (IGD). Among the various executive control problems, high impulsivity has consistently been associated with IGD. We performed voxel-based morphometric analysis with diffeomorphic anatomical registration by using an exponentiated Lie algebra algorithm (DARTEL) to investigate the relationship of gray matter abnormalities to impulsivity in IGD. Thirty-one young male adults whose excessive Internet gaming began in early adolescence, and 30 age-matched male healthy controls were examined...
September 8, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28884874/cerebral-dopaminergic-and-glutamatergic-transmission-relate-to-different-subjective-responses-of-acute-alcohol-intake-an-in-vivo-multimodal-imaging-study
#15
Gil Leurquin-Sterk, Jenny Ceccarini, Cleo Lina Crunelle, Akila Weerasekera, Bart de Laat, Uwe Himmelreich, Guy Bormans, Koen Van Laere
Converging preclinical evidence links extrastriatal dopamine release and glutamatergic transmission via the metabotropic glutamate receptor 5 (mGluR5) to the rewarding properties of alcohol. To date, human evidence is lacking on how and where in the brain these processes occur. Mesocorticolimbic dopamine release upon intravenous alcohol administration and mGluR5 availability were measured in 11 moderate social drinkers by single-session [(18) F]fallypride and [(18) F]FPEB positron emission tomography, respectively...
September 8, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28884870/phosphorylated-snap25-in-the-ca1-regulates-morphine-associated-contextual-memory-retrieval-via-increasing-glun2b-nmdar-surface-localization
#16
Xinjuan Wang, Yan Liu, Meng Jia, Xiaowei Sun, Na Wang, Yijing Li, Cailian Cui
Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2B protein expression in the hippocampal CA1 after morphine conditioned place preference (CPP) expression in rats. Interestingly, we also found that phosphorylation of SNAP25 at Ser187 (pSer187-SNAP25), a PKC-activated target, was significantly increased following morphine CPP expression...
September 8, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28881072/self-efficacy-modulates-the-neural-correlates-of-craving-in-male-smokers-and-ex-smokers-an-fmri-study
#17
Miki Ono, Takanori Kochiyama, Junya Fujino, Takashi Sozu, Ryosaku Kawada, Naoto Yokoyama, Genichi Sugihara, Toshiya Murai, Hidehiko Takahashi
The regulation of cue-induced craving for cigarettes is a key factor in smoking cessation. Outcomes of smoking cessation have been linked to self-efficacy, faith in one's own ability, in smokers. However, no study has examined the neural basis of self-efficacy during the control of craving. We examined whether self-efficacy can affect the neural response to smoking cues in smokers and ex-smokers using functional magnetic resonance imaging. During scanning, participants were instructed (1) to view smoking-related images passively, (2) to view the smoking-related images with a strategy focused on self-efficacy to control cue-induced craving or (3) to view neutral images...
September 7, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28877410/neural-correlates-of-tobacco-cue-reactivity-predict-duration-to-lapse-and-continuous-abstinence-in-smoking-cessation-treatment
#18
Max M Owens, James MacKillop, Joshua C Gray, Steven R H Beach, Michael D Stein, Raymond S Niaura, Lawrence H Sweet
It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic resonance imaging cigarette cue exposure paradigm 2 hours after smoking, and then enrolled in a 9-week smoking cessation treatment program. Neural activation to smoking cues was measured in five a priori defined limbic/paralimbic regions previously implicated with cue reactivity across substances...
September 6, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28877396/neurotensin-in-the-posterior-thalamic-paraventricular-nucleus-inhibitor-of-pharmacologically-relevant-ethanol-drinking
#19
Surya Pandey, Preeti S Badve, Genevieve R Curtis, Sarah F Leibowitz, Jessica R Barson
Individuals prone to ethanol overconsumption may have preexisting neurochemical disturbances that contribute to their vulnerability. This study examined the paraventricular nucleus of the thalamus (PVT), a limbic structure recently shown to participate in ethanol intake. To identify individuals prone to ethanol overconsumption, we tested Long-Evans rats in behavioral paradigms and found high levels of vertical time (rearing behavior) in a novel activity chamber to be a consistent predictor of subsequent excessive 20 percent ethanol drinking under the intermittent access model...
September 6, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28872745/neural-mechanisms-of-extinguishing-drug-and-pleasant-cue-associations-in-human-addiction-role-of-the-vmpfc
#20
Anna B Konova, Muhammad A Parvaz, Vladimir Bernstein, Anna Zilverstand, Scott J Moeller, Mauricio R Delgado, Nelly Alia-Klein, Rita Z Goldstein
The neurobiological mechanisms that underlie the resistance of drug cue associations to extinction in addiction remain unknown. Fear extinction critically depends on the ventromedial prefrontal cortex (VMPFC). Here, we tested if this same region plays a role in extinction of non-fear, drug and pleasant cue associations. Eighteen chronic cocaine users and 15 matched controls completed three functional MRI scans. Participants first learned to associate an abstract cue (the conditioned stimulus, CS) with a drug-related (CSD+ ) or pleasant (CSP+ ) image...
September 5, 2017: Addiction Biology
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