journal
MENU ▼
Read by QxMD icon Read
search

Addiction Biology

journal
https://www.readbyqxmd.com/read/28074543/low-distress-tolerance-predicts-heightened-drug-seeking-and-taking-after-extended-abstinence-from-cocaine-self-administration
#1
Travis M Moschak, Douglas R Terry, Stacey B Daughters, Regina M Carelli
Distress tolerance (DT), defined as the ability to persist in goal-directed behavior while experiencing psychological distress, is associated with greater frequency of substance use and poor treatment outcomes. To examine a potential causal role substance use may play in DT, we developed a rodent model of DT in which rats had to press a lever within a continuously decreasing time window for reward while receiving negative feedback on failure trials. DT was defined as the time rats continued to seek reward before quitting the task...
January 11, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28074533/netrin-g1-its-downregulation-in-the-nucleus-accumbens-of-cocaine-conditioned-mice-and-genetic-association-in-human-cocaine-dependence
#2
Sabah Kelaï, Nicolas Ramoz, Jean-Marie Moalic, Florence Noble, Naguib Mechawar, Sandrine Imbeaud, Gustavo Turecki, Michel Simonneau, Philip Gorwood, Gilles Maussion
Netrin G1 is a presynaptic ligand involved in axonal projection. Although molecular mechanisms underlying cocaine addiction are still poorly understood, Netrin G1 might have a role as a regulator of anxiety, fear and spatial memory, behavioural traits impaired in the context of cocaine exposure. In this study, the Netrin G1 (Ntng1) expression was investigated in the nucleus accumbens of mice primarily conditioned to cocaine using a place preference paradigm. A genetic association study was then conducted on 146 multiplex families of the Collaborative study on Genetics of Alcoholism, in which seven single nucleotide polymorphisms located in the NTNG1 gene were genotyped...
January 11, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28032407/cyp2a6-metabolism-in-the-development-of-smoking-behaviors-in-young-adults
#3
Emily Olfson, Joseph Bloom, Sarah Bertelsen, John P Budde, Naomi Breslau, Andrew Brooks, Robert Culverhouse, Grace Chan, Li-Shiun Chen, David Chorlian, Danielle M Dick, Howard J Edenberg, Sarah Hartz, Dorothy Hatsukami, Victor M Hesselbrock, Eric O Johnson, John R Kramer, Samuel Kuperman, Jacquelyn L Meyers, John Nurnberger, Bernice Porjesz, Nancy L Saccone, Marc A Schuckit, Jerry Stitzel, Jay A Tischfield, John P Rice, Alison Goate, Laura J Bierut
Cytochrome P450 2A6 (CYP2A6) encodes the enzyme responsible for the majority of nicotine metabolism. Previous studies support that slow metabolizers smoke fewer cigarettes once nicotine dependent but provide conflicting results on the role of CYP2A6 in the development of dependence. By focusing on the critical period of young adulthood, this study examines the relationship of CYP2A6 variation and smoking milestones. A total of 1209 European American young adults enrolled in the Collaborative Study on the Genetics of Alcoholism were genotyped for CYP2A6 variants to calculate a previously well-validated metric that estimates nicotine metabolism...
December 29, 2016: Addiction Biology
https://www.readbyqxmd.com/read/28008690/heavy-alcohol-use-in-adolescence-is-associated-with-altered-cortical-activity-a-combined-tms-eeg-study
#4
Outi Kaarre, Elisa Kallioniemi, Mervi Könönen, Tommi Tolmunen, Virve Kekkonen, Petri Kivimäki, Noora Heikkinen, Florinda Ferreri, Eila Laukkanen, Sara Määttä
Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and functional connectivity. In the central nervous system, the effects of alcohol are particularly mediated by alterations in gamma-aminobutyric acid (GABA)ergic neurotransmission, and TMS-evoked potentials (TEPs) N45 and N100 in EEG are known to reflect GABAergic function...
December 23, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27957784/d-cycloserine-enhanced-extinction-of-cocaine-induced-conditioned-place-preference-is-attenuated-in-serotonin-transporter-knockout-rats
#5
Peter Karel, Francesca Calabrese, Marco Riva, Paola Brivio, Bas Van der Veen, Liesbeth Reneman, Michel Verheij, Judith Homberg
d-Cycloserine (DCS), a partial NMDA receptor agonist, has been proposed as a cognitive enhancer to facilitate the extinction of drug-related memories. However, it is unknown whether there are individual differences in the efficacy of DCS. Here, we set out to investigate the influence of serotonin transporter (5-HTT) genotype on DCS treatment outcome and the underlying neural mechanism. To that end, we first determined the mRNA levels of several NMDA receptor subunits and observed a reduction in NR1/NR2C receptors in the ventromedial prefrontal cortex and nucleus accumbens of 5-HTT(-/-) compared with 5-HTT(+/+) rats...
December 12, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27943592/smokers-and-ex-smokers-have-shared-differences-in-the-neural-substrates-for-potential-monetary-gains-and-losses
#6
Liam J Nestor, Ella McCabe, Jennifer Jones, Luke Clancy, Hugh Garavan
Despite an increased understanding of nicotine addiction, there is a scarcity of research comparing the neural correlates of non-drug reward between smokers and ex-smokers. Long-term changes in reward-related brain functioning for non-drug incentives may elucidate patterns of functioning that potentially contribute to ongoing smoking behaviour in current smokers. Similarly, examining the effects of previous chronic nicotine exposure during a period of extended abstinence may reveal whether there are neural correlates responsible for non-drug reward processing that are different from current smokers...
December 12, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27917569/distinct-intrinsic-functional-brain-network-abnormalities-in-methamphetamine-dependent-patients-with-and-without-a-history-of-psychosis
#7
Jonathan C Ipser, Anne Uhlmann, Paul Taylor, Brian H Harvey, Don Wilson, Dan J Stein
Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default mode networks (DMNs) has also been associated with poor cognitive function in clinical populations. Accordingly, we tested the extent to which methamphetamine use predicts abnormal connectivity between these networks, and whether, as predicted, these abnormalities are compounded in patients with a history of methamphetamine-associated psychosis (MAP)...
December 5, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27917562/putamen-functional-connectivity-during-inhibitory-control-in-smokers-and-non-smokers
#8
Sophie E A Akkermans, Maartje Luijten, Daan van Rooij, Ingmar H A Franken, Jan K Buitelaar
The putamen has been shown to play a key role in inhibitory control and addiction, and consists of distinct subregions associated with distinct functions. The anterior putamen is thought to be specialized in goal-directed control or response-monitoring in connection with frontal regions, whereas the posterior part is specialized in habitual or automatic responding in connection with sensorimotor regions. The present study is the first to delineate functional networks of the anterior and posterior putamen in a Go-NoGo response inhibition task, and to examine differences between smokers (n = 25) and non-smokers (n = 23) within these networks...
December 5, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27910188/comparing-rewarding-and-reinforcing-properties-between-bath-salt-3-4-methylenedioxypyrovalerone-mdpv-and-cocaine-using-ultrasonic-vocalizations-in-rats
#9
Steven J Simmons, Ryan A Gregg, Fionya H Tran, Lili Mo, Eva von Weltin, David J Barker, Taylor A Gentile, Lucas R Watterson, Scott M Rawls, John W Muschamp
Abuse of synthetic psychostimulants like synthetic cathinones has risen in recent years. 3,4-Methylenedioxypyrovalerone (MDPV) is one such synthetic cathinone that demonstrates a mechanism of action similar to cocaine. Compared to cocaine, MDPV is more potent at blocking dopamine and norepinephrine reuptake and is readily self-administered by rodents. The present study compared the rewarding and reinforcing properties of MDPV and cocaine using systemic injection dose-response and self-administration models...
December 1, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27894160/cue-induced-nicotine-seeking-behavior-after-withdrawal-with-or-without-extinction-in-rats
#10
Athina Markou, Jie Li, Kearny Tse, Xia Li
Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-induced nicotine-seeking behavior under different withdrawal conditions in rats with a history of nicotine self-administration. We found that non-reinforced operant responding during cue-induced nicotine seeking after different periods of withdrawal from nicotine exhibited an inverted U-shaped curve, with higher levels of responding after 7-21 days of withdrawal than those after 1-day withdrawal...
November 28, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27894158/craving-behavioral-intervention-for-internet-gaming-disorder-remediation-of-functional-connectivity-of-the-ventral-striatum
#11
Jin-Tao Zhang, Shan-Shan Ma, Chiang-Shan R Li, Lu Liu, Cui-Cui Xia, Jing Lan, Ling-Jiao Wang, Ben Liu, Yuan-Wei Yao, Xiao-Yi Fang
Psychobehavioral intervention is an effective treatment of Internet addiction, including Internet gaming disorder (IGD). However, the neural mechanisms underlying its efficacy remain unclear. Cortical-ventral striatum (VS) circuitry is a common target of psychobehavioral interventions in drug addiction, and cortical-VS dysfunction has been reported in IGD; hence, the primary aim of the study was to investigate how the VS circuitry responds to psychobehavioral interventions in IGD. In a cross-sectional study, we examined resting-state functional connectivity of the VS in 74 IGD subjects (IGDs) and 41 healthy controls (HCs)...
November 28, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27859998/impact-of-alcohol-use-on-eeg-dynamics-of-response-inhibition-a-cotwin-control-analysis
#12
Jeremy Harper, Stephen M Malone, William G Iacono
Research indicates that alcohol misuse is associated with behavioral disinhibition, but the neurophysiological mechanisms governing this relationship remain largely unknown. Recent work suggests that successful inhibition and cognitive control involve electrophysiological theta-band dynamics, including medial frontal cortex (MFC) power enhancement and functional connectivity between the MFC and dorsal prefrontal cortex (dPFC) regions, which may be disrupted by alcohol misuse. In addition, research suggests that, compared to men, women are at heightened risk of experiencing the negative physical and neurocognitive correlates of drinking...
November 18, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27860025/low-level-alcohol-consumption-during-adolescence-and-its-impact-on-cognitive-control-development
#13
Sarah Jurk, Eva Mennigen, Thomas Goschke, Michael N Smolka
Adolescence is a critical period for maturation of cognitive control and most adolescents start experimenting with alcohol around that time. On the one hand, recent studies indicate that low control abilities predict future problematic alcohol use. On the other hand, binge drinking during young adulthood can (further) impair cognitive control. However, so far no study examined the effects of low-level alcohol use during adolescence. In the present longitudinal fMRI study, we therefore investigated the development of cognitive control in a community-based sample of 92 adolescents at ages 14, 16 and 18...
November 17, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27860181/methamphetamine-self-administration-reduces-alcohol-consumption-and-preference-in-alcohol-preferring-p-rats
#14
Madeline C Winkler, Emilee M Greager, Jacob Stafford, Ryan K Bachtell
Subclinical levels of polysubstance use are a prevalent and understudied phenomenon. Alcohol is a substance commonly co-used with other substances of other drug classes. These studies sought to determine the consumption effects of combining alcohol drinking and methamphetamine (MA) self-administration. Male alcohol-preferring P rats had continuous access to a two-bottle alcohol drinking procedure in the home cage. Control rats remained alcohol naïve. Rats were also surgically implanted with intra-jugular catheters and trained to self-administer saline (control) or MA in daily 2-hour sessions...
November 16, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27862708/the-role-of-ca3-ls-vta-loop-in-the-formation-of-conditioned-place-preference-induced-by-context-associated-reward-memory-for-morphine
#15
Jin-Xiang Jiang, Huan Liu, Zhen-Zhen Huang, Yue Cui, Xue-Qin Zhang, Xiao-Long Zhang, Yu Cui, Wen-Jun Xin
Addiction-related behaviors, such as conditioned place preference (CPP), require animals to remember an association between environmental cue and drug treatment, and exposure to environmental cue is one of the key contributing factors to relapse. However, how central neural circuit participates in the formation of CPP induced by stimulus of morphine-paired environment remains unknown. In the present study, we found that reexposure to morphine-paired environment significantly increased the activity of hippocampal CA3 neurons, increased the excitability of GABAergic neurons and expression of glutamic acid decarboxylase 65/67 in the caudal lateral septum (LSc) and decreased the activity of GABAergic neurons and GAD65/67 expression in ventral tegmental area (VTA), leading to activation (disinhibition) of dopaminergic neurons...
November 11, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27862692/ppar%C3%AE-agonism-attenuates-cocaine-cue-reactivity
#16
William R Miller, Robert G Fox, Sonja J Stutz, Scott D Lane, Larry Denner, Kathryn A Cunningham, Kelly T Dineley
Cocaine use disorder is a chronic relapsing condition characterized by compulsive drug seeking and taking even after prolonged abstinence periods. Subsequent exposure to drug-associated cues can promote intense craving and lead to relapse in abstinent humans and rodent models. The responsiveness to these cocaine-related cues, or 'cue reactivity', can trigger relapse and cocaine-seeking behaviors; cue reactivity is measurable in cocaine-dependent humans as well as rodent models. Cue reactivity is thought to be predictive of cocaine craving and relapse...
November 11, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27860050/characterization-of-hangover-following-intravenous-alcohol-exposure-in-social-drinkers-methodological-and-clinical-implications
#17
Vatsalya Vatsalya, Bethany L Stangl, Veronica Y Schmidt, Vijay A Ramchandani
Hangover refers to the cluster of physiological and behavioral symptoms that occur following the end of a drinking episode. While hangover has been studied after the typical oral consumption of alcohol, the occurrence of hangover following intravenous (IV) alcohol administration in human laboratory studies has not been previously reported. This study characterizes hangover symptoms and post-infusion drinking behavior following acute IV alcohol administration in social drinkers. Twenty-one to thirty-year-old healthy social drinkers (n = 24) underwent an alcohol clamp session at breath alcohol concentration of 0...
November 11, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27859963/repeated-restraint-stress-exposure-during-early-withdrawal-accelerates-incubation-of-cue-induced-cocaine-craving
#18
Ryan M Glynn, J Amiel Rosenkranz, Marina E Wolf, Aaron Caccamise, Freya Shroff, Alyssa B Smith, Jessica A Loweth
A major challenge for treating cocaine addiction is the propensity for abstinent users to relapse. Two important triggers for relapse are cues associated with prior drug use and stressful life events. To study their interaction in promoting relapse during abstinence, we used the incubation model of craving and relapse in which cue-induced drug seeking progressively intensifies ('incubates') during withdrawal from extended-access cocaine self-administration. We tested rats for cue-induced cocaine seeking on withdrawal day (WD) 1...
November 11, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27813228/metabolic-alterations-in-the-anterior-cingulate-cortex-and-related-cognitive-deficits-in-late-adolescent-methamphetamine-users
#19
Jieun E Kim, Geon Ha Kim, Jaeuk Hwang, Jung Yoon Kim, Perry F Renshaw, Deborah A Yurgelun-Todd, Binna Kim, Ilhyang Kang, Saerom Jeon, Jiyoung Ma, In Kyoon Lyoo, Sujung Yoon
The adolescent brain, with ongoing prefrontal maturation, may be more vulnerable to drug use-related neurotoxic changes as compared to the adult brain. We investigated whether the use of methamphetamine (MA), a highly addictive psychostimulant, during adolescence affect metabolic and cognitive functions of the anterior cingulate cortex (ACC). In adolescent MA users (n = 44) and healthy adolescents (n = 53), the levels of N-acetyl aspartate (NAA), a neuronal marker, were examined in the ACC using proton magnetic resonance spectroscopy...
November 4, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27790823/the-new-designer-drug-buphedrone-produces-rewarding-properties-via-dopamine-d1-receptor-activation
#20
Ji-Hwan Oh, Ji-Young Hwang, Sa-Ik Hong, Shi-Xun Ma, Jee-Yeon Seo, Seok-Yong Lee, Hyoung-Chun Kim, Choon-Gon Jang
Substituted cathinones are synthetic analogs of the active components of natural products and are widely abused worldwide. However, the rewarding properties of these agents have not yet been evaluated. In this study, we investigated the abuse potential of buphedrone [2-(methylamino)-1-phenylbutan-1-one, α-methylamino-butyrophenone] and its effects on the mesolimbic dopaminergic system in mice using conditioned place preference (CPP) analysis, a self-administration test, a locomotor activity test, a behavioral sensitization test and Western blot analysis...
October 27, 2016: Addiction Biology
journal
journal
32482
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"