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Journal of Experimental Therapeutics & Oncology

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https://www.readbyqxmd.com/read/28472569/cancer-meter-measure-and-cure
#1
Sunil Kumar Kashyap, Birendra Kumar Sharma, Amitabh Banerjee
This paper presents a theory and system on "Cancer-Meter'. This idea came through the statement that "cancer is curable if it is measurable". The Cancer-Meter proves that it is possible. This paper proposes the cancer-meter in two ways, theoretical and electronically, as per the measurement and treatment. By the mathematics, first part is defined but the second part is based on computer programming, electrical and electronics. Thus, the cancer-meter is a programmed-electrical-electronic device which measures and cures the cancer both...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472568/bidi-smoking-an-underestimated-issue-of-indian-society
#2
Solanki Jitender, Gupta Sarika, Prachi Sharma, Priyanka Mishra
Bidi smoking has always been an under-talked issue of Indian society. Bidis are rolled in tendu leaves which are non porous and have low combustibility due to which they affect the smoker's lungs even more. In spite of the increased toxicology associated with bidis, they are often ignored. The reason for this can be attributed to their home-made production, decreased taxation and the greater prevalence of bidis in rural areas. Since bidis are rolled and packed at home, packaging does not have any warnings about the harmful effects of bidi smoking...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472567/long-term-benefit-of-intra-arterial-bevacizumab-for-recurrent-glioblastoma
#3
Rachel A Alter, Timothy G White, Andrew A Fanous, Shamik Chakraborty, Christopher G Filippi, David J Pisapia, Apostolos John Tsiouris, John A Boockvar
Standard treatment for recurrent GBM is not yet established. We present a case demonstrating the benefit of intra-arterial (IA) bevacizumab with blood brain barrier disruption (BBBD) for the treatment of recurrent GBM. A 31 year-old man diagnosed with GBM, following primary resection, received temozolomide. After a second resection, he received one dose of IA bevacizumab with BBBD using mannitol, preventing regrowth for 2.5 years. Following tumor regrowth, the patient received another dose of IA bevacizumab with BBBD, which has prevented regrowth for another year...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472566/osteosarcoma-a-diagnostic-dilemma
#4
Swati Pant, Swati Tripathi, Ramakant Dandriyal, Madhusudan Astekar, Atul Joshi
Osteosarcoma is a primeval disease which is still partly understood. It is a malignancy of mesenchymal cells that have the capacity to generate osteoid or immature bone. There have been an abundance of debate and controversies about the nature, aggressiveness, behavior, and various treatment modalities of this entity. Different histologic variation has been common in osteosarcoma; hence multiple diagnostic approaches are vital in all cases. Detection of precise anatomic and histologic variants is of prime importance in view of better outcome...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472565/basal-cell-adenoma-of-palatal-glands
#5
Gayathri Ramesh, Amrita Raj, Ramesh Nagarajappa, Amit Pandey
Salivary gland neoplasms represent less than 3% of all tumors in the general population of which benign adenomas account for 65.5%. Basal cell adenoma which is classified as a subtype of monomorphic adenomas accounts for 1-2% of all salivary gland epithelial tumors, and more than 80% of them arise in the major salivary glands, mostly the parotid gland and has female predominance reporting mostly in the elderly age groups. We here report a case of basal cell adenoma of trabecular type in a male patient of age 45 years in the minor salivary glands of left posterior palatal region...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472564/entering-the-double-digits-ewing-sarcoma-in-adult-maxilla
#6
Mala Kamboj, Anju Devi, Virendra Singh, Sunita Singh
Ewing sarcoma is a rare malignant pediatric sarcoma of bone and soft tissues, which is more unusual in head and neck region. Although the exact histogenesis is still unknown, various cells have been proposed as cells of origin namely, endothelial, hematopoietic, fibroblastic, mesenchymal stem cells or neural derived mesenchymal stem cells. ES is more common in younger age group and among the gnathic bones, mandible is affected more than maxilla. This paper presents the first case of Ewing Sarcoma in the maxilla being reported in the adult age group from India and among the very few reported worldwide...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472563/educating-the-handicraft-factory-workers-about-tobacco-cessation-and-to-assess-its-effectiveness-by-motivational-interviewing-an-intervention-study
#7
Rajeev Mahajan, Jitender Solanki, Raghvendra S Kurdekar, Sarika Gupta, Ashish Modh, OmPrakash Yadav
INTRODUCTION: Tobacco use is considered to be global pandemic. The study was done to assess the effectiveness of smoking cessation intervention among workers by motivational interviewing among handicraft factories, Jodhpur, Rajasthan. METHODOLOGY: An interventional study was carried out among 400 handicraft factory workers on the basis of inclusion and exclusion criterion. Twenty one handicraft factories were taken into consideration. Training, Standardization and Calibration of Examiners was carried out in the public health department...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472562/prevalence-of-odontogenic-lesions-among-the-kanpur-population-an-institutional-study
#8
Amrita Raj, Gayathri Ramesh, Ramesh Nagarajappa, Amit Pandey, Ankita Raj
BACKGROUND: The frequency and incidence of odontogenic cysts and tumors are controversial and depends in the geographic location. These lesions have great clinical and histopathological diversity, and reflect a need for epidemiological profile to be considered when these lesions are studied. AIM: The purpose of this study was to determine the prevalence of odontogenic cysts and tumors over a period of 10 years and to compare with other data reported around the world...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472561/effect-of-steroid-and-serum-starvation-on-a-human-breast-cancer-adenocarcinoma-cell-line
#9
Maryam Nakhjavani, David J Stewart, Farshad H Shirazi
Breast cancer is one of the most frequent cancers in women. Although there are many treatment protocols for this disease, there are still many patients who do not respond satisfactorily to the current treatment protocols. A better understanding of the nature of the tumor cells might provide a guide for better therapeutic procedures. In this study, the effect of metabolic stress was assessed on the human adenocarcinoma MCF-7 cell line. The cells were seeded in culture plates and after reaching log phase of their growth, cells were exposed to phenol red free-media supplemented with 10%, 0...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472560/nedaplatin-and-irinotecan-with-concurrent-thoracic-radiotherapy-followed-by-docetaxel-consolidation-in-patients-with-locally-advanced-non-small-cell-lung-cancer
#10
Fumihiro Oshita, Shuji Murakami, Tetsuro Kondo, Haruhiro Saito, Kouzo Yamada, Yuko Nakayama
OBJECTIVE: We conducted a phase II study of nedaplatin (NP) and irinotecan (CPT) with concurrent thoracic radiotherapy (TRT) followed by docetaxel for locally advanced non-small cell lung cancer (NSCLC) to determine the safety and efficacy of the treatment. Patients with stage IIIA or IIIB NSCLC were treated with 3 cycles of chemotherapy comprising NP at 50 mg/m(2) and CPT at 50 mg/m(2) on days 1 and 8 every 4 weeks with concurrent TRT (2 Gy/day, total 66 Gy) followed by 3 cycles of docetaxel at 60 mg/m(2) on day 1 every 3 weeks...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472559/role-of-oxidative-stress-in-epithelial-ovarian-cancer-in-egyptian-patients
#11
Asmaa Ramadan, Reda Hemida, Ahmed Nowara, Laila A Eissa, Amal M El-Gayar
BACKGROUND: Ovarian cancer has the highest mortality rate amongst all gynecologic malignancies. 90% of the cases are epithelial ovarian cancer (EOC). Ovarian cancer associated with reduction in the serum level of antioxidants super oxide dismutase (SOD) and glutathione peroxidase (GPX) and increasing in the serum level of Malondialdehyde (MDA). OBJECTIVE: To find correlation between oxidative stress and epithelial ovarian cancer. METHODS: In this cross-sectional study fifty-six female patients with EOC, twenty four female patients with benign ovarian tumors and ten healthy females were included in the current research study where serum level of SOD, GPX and MDA were measured...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28472558/cellular-glutathione-level-does-not-predict-ovarian-cancer-cells-resistance-after-initial-or-repeated-exposure-to-cisplatin
#12
Nastaran Nikounezhad, Maryam Nakhjavani, Farshad H Shirazi
OBJECTIVE: Cisplatin resistance development is a major obstacle in ovarian cancer treatment. One of the most important mechanisms underlying cisplatin resistance is drug detoxification by glutathione. In the present study, the importance of initial or repeated exposure to cisplatin in glutathione dependent resistance was investigated. To this purpose, some cisplatin sensitive and resistant variants of human ovarian cancer cell lines providing an appropriate range of cisplatin sensitivity were selected...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849344/oral-squamous-papilloma-occurring-on-the-palate-with-review-of-literature
#13
Anjali Nayak, Meghanand T Nayak
Squamous papillomas are common lesions occurring on skin, oral and nasal mucosa and male and female genital organs. Oral squamous cell papilloma (OSP) is a benign proliferation of the stratified squamous epithelium and is generally believed to be caused by Human Papilloma Viruses (HPV). It constitutes around 2.5% of all oral verruco-papillary lesions. We here, report a case of palatal OSP occurring in a 55-year-old male. The aetiological, clinical, diagnostic and treatment aspects of OSP are discussed here.
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849343/recurrent-uterine-leiomyosarcoma-an-atypical-location
#14
Mesut Köse, Fatih Çelik, Seda Kayman Köse, Dağıstan Tolga Arıöz, Mehmet Yılmazer, Çiğdem Tokyol
Leiomyosarcoma (LMS) is a malignant tumor of smooth muscle cells and comprises 5-24% of all soft tissue sarcomas. Although the most frequent symptoms are vaginal bleeding and abdominal pain, the symptoms are generally associated with dimensions and localization of the tumor. The current study presents a case of uterine leiomyosarcoma that metastasized to the rectus abdominis muscle, which has only been previously reported in two cases in the literature. A 57-year-old multigravid patient presented with a palpable mass in her abdomen...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849342/dentigerous-cyst-associated-with-ectopically-impacted-maxillary-second-premolar
#15
Sulabha An, Bhari Sharanesha Manjunatha, Madhusudan Astekar, Sameer C
Dentigerous cysts are benign odontogenic cysts that are accompanying with the crown of permanent teeth. They are typically single in incidence and are situated in the mandible. They are usually associated with impacted mandibular third molar and maxillary canines. Here we report a very rare presentation of dentigerous cyst in anterior maxilla accompanying with ectopically impacted maxillary second premolar. The cyst was enucleated along with extraction of premolar.
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849341/screening-for-oral-cancer
#16
Solanki Jitender, Gupta Sarika, Hiremath R Varada, Yadav Omprakash, Khan Mohsin
Oral cancer is considered as a serious health problem resulting in high morbidity and mortality. Early detection and prevention play a key role in controlling the burden of oral cancer worldwide. The five-year survival rate of oral cancer still remains low and delayed diagnosis is considered as one of the major reasons. This increases the demand for oral screening. Currently, screening of oral cancer is largely based on visual examination. Various evidence strongly suggest the validity of visual inspection in reducing mortality in patients at risk for oral cancer...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849340/intra-arterial-cetuximab-for-the-treatment-of-recurrent-unresectable-head-and-neck-squamous-cell-carcinoma-%C3%A2
#17
Tristan Tham, Timothy G White, Shamik Chakraborty, Rohan R Lall, Rafael Ortiz, David J Langer, Deborah Shatzkes, Christopher G Filippi, Dennis Kraus, John A Boockvar, Peter D Costantino
IMPORTANCE: Management of recurrent head and neck squamous cell carcinoma is a common and challenging clinical problem in head and neck oncology. OBJECTIVE: Here we present the first reported case of super-selective intra-arterial (SSIA) microcatheter based local delivery of cetuximab for head and neck cancer. This technical report describes the techniques used to deliver the SSIA dose of cetuximab, as well as the patient outcome. DESIGN: This technical report is part of an ongoing Phase I Clinical Trial...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849339/immunohistochemical-study-of-p21-and-bcl-2-in-leukoplakia-oral-submucous-fibrosis-and-oral-squamous-cell-carcinoma
#18
Rakesh V Sutariya, Bhari Sharanesha Manjunatha
BACKGROUND: Oral Squamous cell carcinoma (OSCC) results from genetic damage, leading to uncontrolled cell proliferation of damaged cells and the cell death. In the course of its progression, visible changes are taking place at the cellular level (atypical) and the resultant at the tissue level (epithelial dysplasia). OBJECTIVES: The Aim of the present study was to evaluate and compare the expressions of intensity of p21 and Bcl-2 in Leukoplakia, oralsubmucous fibrosis (OSMF) and oral squamous cell carcinoma...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849338/neck-dissections-emerging-role-of-oral-pathologists
#19
Madhusudan Astekar, Amolika Choube, Gaurav Sapra, Rajesh Kumar Chitlangiya
BACKGROUND: Surgical resection has been the principle treatment approach for early lesions as well as advanced stage carcinomas of upper aero digestive tract. Neck dissection is the primary treatment given to nodal metastasis of oral carcinomas. Choice of irradiation and chemotherapy post surgery relies heavily on the histopathological assessment of surgical margins of resected tumor, dissected lymph nodes and accessory tissues. METHODS: A total of ten cases of head and neck carcinomas reported in two years period were analyzed...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849337/the-role-of-oxidative-stress-markers-in-development-of-endometrial-polyp
#20
Mehmet Çınar, Özlem Gün Eryılmaz, Şule Özel, Rahime Bedir Fındık, Hatice Kansu, Gülnur Özakşit
OBJECTIVE: To evaluate the association of the oxidative stress markers in patients with endometrial polyp. METHODS: A total of forty nine patients between 28-47 years of ages who have a suspect evidence of endometrial polyp on transvaginal sonography were enrolled for the study. Hysterosonography was applied all of the patients and patients then were divided into two groups in terms of their hysteroscopic findings. Group 1(control group, n=27) defined who has no endometrial pathology and group 2 (study group, n=22) defined has one or more endometrial polyp on hysteroscopy with guided biopsy...
November 2016: Journal of Experimental Therapeutics & Oncology
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