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Journal of Experimental Therapeutics & Oncology

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https://www.readbyqxmd.com/read/27849344/oral-squamous-papilloma-occurring-on-the-palate-with-review-of-literature
#1
Anjali Nayak, Meghanand T Nayak
Squamous papillomas are common lesions occurring on skin, oral and nasal mucosa and male and female genital organs. Oral squamous cell papilloma (OSP) is a benign proliferation of the stratified squamous epithelium and is generally believed to be caused by Human Papilloma Viruses (HPV). It constitutes around 2.5% of all oral verruco-papillary lesions. We here, report a case of palatal OSP occurring in a 55-year-old male. The aetiological, clinical, diagnostic and treatment aspects of OSP are discussed here.
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849343/recurrent-uterine-leiomyosarcoma-an-atypical-location
#2
Mesut Köse, Fatih Çelik, Seda Kayman Köse, Dağıstan Tolga Arıöz, Mehmet Yılmazer, Çiğdem Tokyol
Leiomyosarcoma (LMS) is a malignant tumor of smooth muscle cells and comprises 5-24% of all soft tissue sarcomas. Although the most frequent symptoms are vaginal bleeding and abdominal pain, the symptoms are generally associated with dimensions and localization of the tumor. The current study presents a case of uterine leiomyosarcoma that metastasized to the rectus abdominis muscle, which has only been previously reported in two cases in the literature. A 57-year-old multigravid patient presented with a palpable mass in her abdomen...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849342/dentigerous-cyst-associated-with-ectopically-impacted-maxillary-second-premolar
#3
Sulabha An, Bhari Sharanesha Manjunatha, Madhusudan Astekar, Sameer C
Dentigerous cysts are benign odontogenic cysts that are accompanying with the crown of permanent teeth. They are typically single in incidence and are situated in the mandible. They are usually associated with impacted mandibular third molar and maxillary canines. Here we report a very rare presentation of dentigerous cyst in anterior maxilla accompanying with ectopically impacted maxillary second premolar. The cyst was enucleated along with extraction of premolar.
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849341/screening-for-oral-cancer
#4
Solanki Jitender, Gupta Sarika, Hiremath R Varada, Yadav Omprakash, Khan Mohsin
Oral cancer is considered as a serious health problem resulting in high morbidity and mortality. Early detection and prevention play a key role in controlling the burden of oral cancer worldwide. The five-year survival rate of oral cancer still remains low and delayed diagnosis is considered as one of the major reasons. This increases the demand for oral screening. Currently, screening of oral cancer is largely based on visual examination. Various evidence strongly suggest the validity of visual inspection in reducing mortality in patients at risk for oral cancer...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849340/intra-arterial-cetuximab-for-the-treatment-of-recurrent-unresectable-head-and-neck-squamous-cell-carcinoma-%C3%A2
#5
Tristan Tham, Timothy G White, Shamik Chakraborty, Rohan R Lall, Rafael Ortiz, David J Langer, Deborah Shatzkes, Christopher G Filippi, Dennis Kraus, John A Boockvar, Peter D Costantino
IMPORTANCE: Management of recurrent head and neck squamous cell carcinoma is a common and challenging clinical problem in head and neck oncology. OBJECTIVE: Here we present the first reported case of super-selective intra-arterial (SSIA) microcatheter based local delivery of cetuximab for head and neck cancer. This technical report describes the techniques used to deliver the SSIA dose of cetuximab, as well as the patient outcome. DESIGN: This technical report is part of an ongoing Phase I Clinical Trial...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849339/immunohistochemical-study-of-p21-and-bcl-2-in-leukoplakia-oral-submucous-fibrosis-and-oral-squamous-cell-carcinoma
#6
Rakesh V Sutariya, Bhari Sharanesha Manjunatha
BACKGROUND: Oral Squamous cell carcinoma (OSCC) results from genetic damage, leading to uncontrolled cell proliferation of damaged cells and the cell death. In the course of its progression, visible changes are taking place at the cellular level (atypical) and the resultant at the tissue level (epithelial dysplasia). OBJECTIVES: The Aim of the present study was to evaluate and compare the expressions of intensity of p21 and Bcl-2 in Leukoplakia, oralsubmucous fibrosis (OSMF) and oral squamous cell carcinoma...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849338/neck-dissections-emerging-role-of-oral-pathologists
#7
Madhusudan Astekar, Amolika Choube, Gaurav Sapra, Rajesh Kumar Chitlangiya
BACKGROUND: Surgical resection has been the principle treatment approach for early lesions as well as advanced stage carcinomas of upper aero digestive tract. Neck dissection is the primary treatment given to nodal metastasis of oral carcinomas. Choice of irradiation and chemotherapy post surgery relies heavily on the histopathological assessment of surgical margins of resected tumor, dissected lymph nodes and accessory tissues. METHODS: A total of ten cases of head and neck carcinomas reported in two years period were analyzed...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849337/the-role-of-oxidative-stress-markers-in-development-of-endometrial-polyp
#8
Mehmet Çınar, Özlem Gün Eryılmaz, Şule Özel, Rahime Bedir Fındık, Hatice Kansu, Gülnur Özakşit
OBJECTIVE: To evaluate the association of the oxidative stress markers in patients with endometrial polyp. METHODS: A total of forty nine patients between 28-47 years of ages who have a suspect evidence of endometrial polyp on transvaginal sonography were enrolled for the study. Hysterosonography was applied all of the patients and patients then were divided into two groups in terms of their hysteroscopic findings. Group 1(control group, n=27) defined who has no endometrial pathology and group 2 (study group, n=22) defined has one or more endometrial polyp on hysteroscopy with guided biopsy...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849336/durability-of-single-dose-intra-arterial-bevacizumab-after-blood-brain-barrier-disruption-for-recurrent-glioblastoma
#9
Shamik Chakraborty, Christopher G Filippi, Jan-Karl Burkhardt, Sherese Fralin, Ashley Ray, Tamika Wong, Rafael Ortiz, David J Langer, John A Boockvar
BACKGROUND: Bevacizumab (BV) has been used to treat recurrent glioblastoma with a progression free survival of approximately 3-3.5 months. Typically, it is administered intravenously every 2-3 weeks at dosages ranging from 5-15 mg/kg. Serious side effects include GI tract perforations, hematologic disorders, intracranial hemorrhage, and malignant hypertension. We hypothesized that selective intracranial intra-arterial infusion (SIACI) of BV following blood/brain barrier disruption (BBBD) with mannitol may allow for reduced dosage, lower toxicity, and equivalent or superior progression free survival (PFS)...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849335/mycotoxin-verrucarin-a-inhibits-proliferation-and-induces-apoptosis-in-prostate-cancer-cells-by-inhibiting-prosurvival-akt-nf-kb-mtor-signaling
#10
Yongbo Liu, Xiaohua Gao, Dorrah Deeb, Yiguan Zhang, Jiajiu Shaw, Frederick A Valeriote, Subhash C Gautam
Trichothecenes are powerful mycotoxins that inhibit protein synthesis and induce ribotoxic stress response in mammalian cells. Verrucarin A (VC-A) is a Type D macrocyclic mycotoxin which inhibits cell proliferation and induces apoptosis in cancer cells. However, the antitumor activity of VC-A for prostate cancer cells has not been investigated. The objective of the present study was to determine the anticancer activity and its mechanism of action in hormone-responsive (LNCaP) and hormone-refractory (PC-3) carcinoma of the prostate (CaP) cell lines...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27849334/potential-role-of-increasing-number-of-sections-in-frozen-section-diagnosis-of-ovarian-tumors
#11
Ali Ayhan, Ali Ozler, Polat Dursun, A Nihan Haberal
OBJECTIVE: To assess the accuracy of intraoperative frozen section of ovarian tumours at our institution and to identify the possible reasons for misdiagnosis. STUDY DESIGN: Between January 2002 and August 2013, a total of 684 patients were included in the study. Frozen section diagnosis was compared with the final paraffin section diagnosis as the gold standard. The sensitivity, specificity, and positive and negative predictive values of frozen-section diagnosis were calculated for benign, borderline and malignant tumours...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259394/dr-samokhotskiy-s-method-of-healing-inflammation-by-the-analysis-and-regulation-of-blood-electrolyte-balance
#12
REVIEW
Vadym V Bacherikov, Valeriy A Bacherikov
An overview of a little-known method, which was discovered by Dr. Alexander S. Samokhotskiy, for treatment of gangrenous, traumatic, and postoperative inflammation, sepsis and some other diseases, was represented. Dr. A. S. Samokhotskiy carried out numerous animal experiments and clinical trials and found that application of wet bandages and/or intravenous injection of solution containing trivalent chromium ions (Cr3+), alum, resorcinol, sodium salicylate, lactate buffer, colloidal sulphur, thioglycolic acid and glutathione with adding KCl, MgCI2, CaCl2 or NaCl solutions can heal inflammation of various etiology...
2015: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259393/unilateral-angiokeratoma-of-vulva-a-rare-clinic-entity
#13
Aytekin Tokmak, Demet Kokanali, Nagihan Ozcan Cengaver, Gülçin Yildirim, Ali Irfan Güzel, Nafiye Yilmaz
The aim of this study is to present a very rare dermatologic condition of the vulva. Angiokeratoma is a benign dilation of ectatic thin-walled blood vessels and congested capillaries in the superficial dermal layer of skin. It occurs predominantly in men and extremely rare in women. Angiokeratoma presents as single or multiple papular lesions on the vulva with smooth or verrucous surface. These lesions are easily confused with infectious disease, inflammatory lesions, and epithelial tumors. In this report, we presented a 42 year old unmarried woman who was admitted to our clinic with complaints of two papuler lesions of the right labium majus with vaginal discharge, vulvar pruritis, and vulvar edema...
2015: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259392/in-human-alleles-specific-variation-of-mthfr-c677t-and-a1298c-associated-risk-factor-for-the-development-of-ovarian-cancer
#14
Anupama Singh, S Pandey, L K Pandey, Ajit K Saxena
Etiopathology of tumor biology is highly complex and ovarian cancer is one of the important gynaecological neoplasia associated with high risk of mortality rate. Methlenetetrahydrofolate reductase (MTHFR) mutation are commonly linked to folate metabolism with increased risk factor for the development of neural tube defects, recurrent pregnancy loss and development of several type of cancer but genetic interaction between two alleles of MTHFR has been poorly defined in ovarian cancer in India. Hence, present study becomes imperative with the aim to assess the alleles frequency of MTHFR (C677T & A1298C) gene polymorphism using PCR based RFLP analysis...
2015: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259391/prevalence-of-quid-induced-lichenoid-reactions-among-western-indian-population
#15
Jitender Solanki, Sarika Gupta
OBJECTIVE: Betel quid and areca nut chewing is widely prevalent in many parts of Asia and Asian migrant communities in the world. Due to the carcinogenicity associated with quid and areca nut we developed an interest to study the prevalence of quid induced oral lichenoid reactions in the population of western India. METHODS: A total population of 4981 males and females was screened for tobacco use and the prevalence of lesion in 86 quid users was seen. The lesions which met the selection criteria of oral lichenoid reaction were identified...
2015: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259390/immunostimulant-and-chemoprotective-effect-of-vivartana-a-polyherbal-formulation-against-cyclophosphamide-induced-toxicity-in-swiss-albino-mice
#16
COMPARATIVE STUDY
Sadhana Gnanasekaran, Kunnathur Murugesan Sakthivel, Guruvayoorappan Chandrasekaran
The aim of the study is to develop a technology for cost effective immunomodulator from natural products to combat adverse effects during cancer chemotherapy. In the present study, the immunomodulatory efficacy of Vivartana, a poly herbal formulation in immunosuppressed animal model induced by cyclophosphamide (CTX) and its comparison with standard herbal immunostimulators Chyawanprash and Brahma Rasayana was investigated. The effect of Vivartana (500 mg/kg x bw) (p.o.), Chyawanprash (20 mg/kg.bw) (p.o.) and Brahma Rasayana (20 mg/kg x bw) (p...
2015: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259389/role-of-telomerase-in-anticancer-activity-of-pristimerin-in-prostate-cancer-cells
#17
Yong Bo Liu, Xiaohua Gao, Dorrah Deeb, Kirit Pindolia, Subhash C Gautam
Pristimerin (PM) is a quinonemethide triterpenoid present in various plant species with strong antiprolifertive and proapoptotic activities in cancer cells. The effect of PM on telomerase which is reactivated in most cancers including carcinoma of the prostate (CaP) has not been studied. We investigated the effect of PM on the expression of human telomerase reverse transcriptase (hTERT) gene that codes for the catalytic subunit of the telomerase holoenzyme complex in prostate cancer cell lines LNCaP and PC-3 cells...
2015: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259388/strategies-used-in-the-clinical-trials-of-gene-therapy-for-cancer
#18
REVIEW
Thekkuttuparambil Ananthanarayanan Ajith
Advances in understanding and manipulating genes have set the stage for scientists to alter a person's genetic material to prevent or treat diseases. Over the past decade, somatic gene therapy has been increasingly applied in clinical trials where the genetic material (DNA and RNA) introduced into a person's cell. Mutation and inactivation of the tumor suppressor genes are the unified concept of the development of tumor in humans. Therefore, researchers have discovered potential of gene therapies in the treatment of cancer...
2015: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259387/tumor-molecular-profiling-in-the-treatment-of-refractory-cancers
#19
K C Birendra, Muhammad Zubair Afzal, Andrew Sochaki, Katherine A Wentland, Rubens Chang, Sudhir Singh, Timothy O'Rourke
INTRODUCTION: Molecular profiling (MP) has been used as a technique to identify treatment regimens for individual patient's cancer. The results of MP has been used to guide targeted therapy specific to each patient's tumor that resulted in a longer progression free survival (PFS) compared to the last conventional treatment. This study aims to provide further data to delineate the PFS of patients who get treated with targeted therapy based on MP. METHODS: A retrospective chart review was performed...
2015: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/26259386/krukenberg-carcinoma-metastasized-from-stomach-resembling-mucinous-cystadenocarcinoma-of-the-ovary
#20
Melike Doğanay, Hasan Onur Topçu, Mahmut Kuntay Kokanali, Ali Irfan Güzel, Asli Oskovi, Serap Akbay, Sabri Cavkaytar
The ovaries are common site of metastasis in a variety of primary neoplasms. Multiple tumors such as breast, lung, and pancreas have been reported to metastasize to the ovary, however; the colon and stomach are the most common primary cancer sites that of ovarian metastasis. An ovarian mass mostly originates from its self-tissue, but sometimes it can be a metastasis of a gastrointestinal system tumor. Such cases are often misdiagnosed as primary ovarian cancers. A 42-year-old woman was admitted to our hospital with pelvic pain...
2015: Journal of Experimental Therapeutics & Oncology
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