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Journal of Experimental Therapeutics & Oncology

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https://www.readbyqxmd.com/read/28976141/population-specific-genetic-variation-at-microrna-629-binding-site-in-the-3-utr-of-nbs1-gene-in-prostate-cancer-patients
#1
Ammad Ahmad Farooqi, Syed M Kamran Majeed, Qaisar Mansoor, Muhammad Ismail
OBJECTIVE: Prostate cancer is a genomically complex disease and recently emerging scientific evidence is adding new pieces of information into existing pool of knowledge of oncology. Prostate cancer cells tactfully rewire signaling cascades in presence or absence of androgen. We do not have finer proteome and genome based patient related information of our cancer patients. METHODOLOGY: In the present laboratory research, we studied 3' UTR C/T and A/G polymorphism in NBS1 gene in 100 prostate cancer patients and 100 healthy individuals without any previous clinical history, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976140/lipoma-of-round-ligament-on-the-intraperitoneal-portion-abdominal-site-a-case-report
#2
Ozhan Ozdemır, Mustafa Erkan Sarı, Vefa Selimova Sakar, Mehriban Nebıoglu, Cemal Resat Atalay
Primary tumors of round ligament are rare, and when found are typically leiomyomas. Endometrioma, and mesothelial cysts are the benign lesions recognized as involving the round ligament. We report a case of lipoma of the round ligament in a 48-year-old premenopausal woman. Round ligament lipoma on the intraperitoneal portion (abdominal site) is very rare and it should be kept in the differential diagnosis of ovarian and abdominal masses.
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976139/cystic-lymphangioma-of-the-lesser-omentum-in-a-pregnant-woman-a-case-report-and-review-of-the-literature
#3
Ozhan Ozdemir, Mustafa Erkan Sarı, Cemal Resat Atalay, Yüksel Kurban, Vusale Asgarova, Devrim Tuba Unal
Lymphangiomas are rare benign tumors which are generally seen in pediatric population and the etiopathogenesis has not yet been understood. They occasionally occur in the head and neck or axillary region with only 5% of them being located in the abdominal or mediastinal cavity. These tumors may be asymptomatic or may cause acute abdominal symptoms due to the location and extention. In the English literature, only 4 cases of lymphangioma were reported to have occurred in the pregnancy period. Herein, we report a case of cystic lymphangioma of the lesser omentum detected incidentally on the ultrasonogram of a 21 year-old, 26-week pregnant woman...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976138/leiomyosarcoma-of-maxilla-a-case-report-with-review-of-literature
#4
Renuka Gupta, Madhusudan Astekar, Ramakant Dandriyal, Manjunath Bs
One challenging feature of head and neck pathology is that a dizzying array of spindle cell lesions occurs here which ranges all the way from reactive, very aggressive forms to malignant lesions. Leiomyosarcoma is one such malignant tumour of mesenchymal origin exhibiting smooth muscle differentiation; presenting generally nonspecific signs and symptoms. Here we present a case of leiomyosarcoma in a 21 year old female patient associated with single reddish pink swelling present in the posterior right maxillary tuberosity region with moderate facial asymmetry...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976137/effect-of-lupeol-on-antioxidants-and-xenobiotic-enzymes-in-n-butyl-n-4-hydroxybutyl-nitrosamine-induced-bladder-carcinogenesis-in-experimental-rats
#5
Bhoopathy Prabhu, Annamalai Sivakumar, Doraisami Balakrishnan, Sivapatham Sundaresan
Urothelial carcinoma of the bladder is a common malignancy ranked 9(th) with an estimated 356,600 new cases diagnosed annually worldwide. The study showed the protective effects of Lupeol in N-Butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in in vivo experimental model. Forty male healthy wistar rats were selected randomly divided into four groups. Group I rats served as healthy control. Group II rats were treated with BBN (150 mg/gavage/twice a week) for 8 weeks. Group III rats were treated with BBN + Lupeol [ Lupeol (50 mg/kg bw/day) treatment was started 1 week prior to the BBN treatment, and it was orally administered for 8 weeks]...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976136/salivary-lactate-dehydrogenase-as-a-prognostic-marker-in-oral-squamous-cell-carcinoma-patients-following-surgical-therapy
#6
Varsha Pathiyil, Audrey Madonna D'Cruz
The objective of the present study was to assay the salivary levels of lactate dehydrogenase in patients with OSCC in comparison to healthy controls and to assess the changes in salivary levels of lactate dehydrogenase as prognostic markers of surgical therapy in oral squamous cell carcinoma patients. A case control study was undertaken comprising of 20 patients who were clinically diagnosed and histopathologically proven with oral squamous cell carcinoma and compared with 20 age and gender matched controls...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976135/poly-mva-attenuates-7-12-dimethylbenz-a-anthracene-initiated-and-croton-oil-promoted-skin-papilloma-formation-on-mice-skin
#7
Ravindran K Veena, Thekkuttuparambil A Ajith, Kainoor K Janardhanan, Francis Antonawich
Chemopreventive agents which exhibit activities such as anti-inflammation, inhibition of carcinogen induced mutagenesis and scavenging of free radical might play a decisive role in the inhibition of chemical carcinogenesis either at the initiation or promotion stage. Many synthesized palladium (Pd) complexes tested experimentally for antitumor activity are found effective. Poly-MVA is a liquid blend preparation containing B complex vitamins, ruthenium with Pd complexed with alpha lipoic acid as the major ingredients...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976134/tumor-protein-53-mutations-mapping-to-its-tertiary-structure-with-in-silico-prediction-of-neoepitopic-vaccine-candidates-in-bone-tumors
#8
Hamid Nawaz Tipu, Abdul Rehman Arshad
Mapping of tp 53 mutations in bone cancers present in COSMIC database to its secondary and tertiary structure with in silico prediction of newly formed HLA binding epitopes as candidates for synthetic peptide vaccine. Mutations in bone cancers present in COSMIC database were listed and manually induced in wt p53 FASTA sequence. Wt p53 secondary structure was predicted. Template identified and tertiary structure of wt p53 was modelled in Cn3D followed by individual mutations mapping onto this model. HLA class I binding affinity was determined for mutated sequences to determine any newly binding peptide sequences...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976133/angiotensin-receptor-signaling-and-prostate-tumor-growth-in-mice
#9
Jem Scott-Emuakpor, Emma Allot, Stacy A Johnson, Lauren E Howard, Everardo Macias, Stephen J Freedland, Susan B Gurley
The renin-angiotensin system, through its type 1 and type 2 angiotensin receptors (AT1R and AT2R, respectively) may have a role in prostate cancer. The objective of this pilot study was to explore that potential role by determining whether the AT1R blocker, losartan, would reduce the growth of LAPC-4 prostate cancer xenografts in nude mice. We also evaluated the tumor growth effects of using angiotensin II to activate both AT1R and AT2R simultaneously. Our data showed that losartan decreased tumor volumes by 56% versus control...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976132/diffuse-large-b-cell-lymphoma-of-hard-palate-a-case-report-with-literature-review
#10
Bhavana Rai, Madhusudan S Astekar, Bhari Sharanesha Manjunatha, Gaurav Sapra
Lymphomas are diverse group of neoplasm affecting the lymphoreticular system. Diffuse large B cell lymphoma is the most frequently diagnosed type of non-Hodgkin lymphoma and is the fifth most frequent malignancy, accounting for about 40% of cases reported. In the present case report a 40 year old female patient complains of swelling on right side of face since 45 days and gradually increased to present size. Intra-orally an ulcero-proliferative growth was present on the right side of hard palate. Incisional biopsy was suggestive of Lymphoproliferative disorder...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976131/chronic-subdural-hematoma-following-spinal-anesthesia-for-cesarean-section
#11
Kübra Mehel Metin, Is Il Güzel, Aslı Oskovi, Ali Irfan Guzel
Intracranial subdural hematoma after spinal anesthesia is a rare and life-threatening complication of spinal anesthesia. The most common complication of spinal anesthesia is the postdural puncture headache. When severe and persistent headache after spinal anesthesia occur, differential diagnosis can be explored. In this report, we aimed to evaluate a patient with persistent headache following spinal anesthesia for cesarean section in a 31-year-old woman ,and emphasize a rare complication of spinal anesthesia which is subdural hematoma...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976130/a-retrospective-analysis-of-tolerance-and-outcomes-of-cutaneous-malignant-melanoma-in-patients-receiving-adjuvant-interferon-alpha-2b-a-community-oncology-perspective
#12
Muhammad Zubair Afzal, Vani Pinnamaneni, K C Birendra, Alan T Davis, Tracy J Koehler, Nehal Lakhani
INTRODUCTION: Interferon alpha 2B (IFN-α) therapy in malignant melanoma has improved relapse free survival and overall survival but is considerably toxic and lowers the overall quality of life (QoL) substantially. A significant number of patients do not complete the full duration (one year) of therapy. OBJECTIVE: The aim of this study was to evaluate patients' ability to tolerate IFN-α therapy and to compare our results to reported data in the literature. METHODS: We conducted a retrospective review of patients diagnosed with cutaneous malignant melanoma who received IFN therapy after surgical resection...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976129/acute-effects-of-low-level-laser-therapy-660-nm-on-oxidative-stress-levels-in-diabetic-rats-with-skin-wounds
#13
Amanda Silveira Denadai, Ricardo Dutra Aydos, Iandara Schettert Silva, Larissa Olmedo, Bruno Mendonça de Senna Cardoso, Baldomero Antonio Kato da Silva, Paulo de Tarso Camillo de Carvalho
BACKGROUND: Laser therapy influences oxidative stress parameters such as the activity of antioxidant enzymes and the production of reactive oxygen species. OBJECTIVE: To analyze the effects of low-level laser therapy on oxidative stress in diabetics rats with skin wounds. METHODS: Thirty-six animals were divided into 4 groups: NDNI: non-diabetic rats with cutaneous wounds that not received laser therapy; NDI: non-diabetic rats with cutaneous wounds that received laser therapy; DNI: diabetic rats with skin wounds who did not undergo laser therapy; DI: rats with diabetes insipidus and cutaneous wounds and received laser therapy...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976128/an-incidental-finding-of-chronic-salpingitis-complications-tubo-uterine-fistula
#14
Aytekin Tokmak, Alev Esercan, Esma Sarıkaya
Pelvic inflammatory disease (PID) is an infection of the upper genital tract in women that can include endometritis, parametritis, salpingitis, oophoritis, tubo-ovarian abscess, and peritonitis. The spectrum of the disease ranges from subclinical and asymptomatic infection to severe, lifethreatening illness; squealae include chronic pelvic pain, ectopic pregnancy, and infertility. In this case we report an uncommon complication of pelvic inflammatory disease, a tubo-uterian fistula. Our case was diagnosed by laparoscopy incidentally during assessment of infertility...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976127/dr-samokhotskiy-s-method-of-healing-inflammation-by-the-analysis-and-regulation-of-blood-electrolyte-balance
#15
Vadym V Bacherikov, Valeriy A Bacherikov
An overview of a little-known method, which was discovered by Dr. Alexander S. Samokhotskiy, for treatment of gangrenous, traumatic, and postoperative inflammation, sepsis and some other diseases, was represented. Dr. A. S. Samokhotskiy carried out numerous animal experiments and clinical trials and found that application of wet bandages and/or intravenous injection of solution containing trivalent chromium ions (Cr(3+)), alum, resorcinol, sodium salicylate, lactate buffer, colloidal sulphur, thioglycolic acid and glutathione with adding KCl, MgCl2, CaCl2 or NaCl solutions can heal inflammation of various etiology...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976126/unilateral-angiokeratoma-of-vulva-a-rare-clinic-entity
#16
Aytekin Tokmak, Demet Kokanalı, Nagihan Özcan Cengaver, Gülçin Yıldırım, Ali I Rfan Güzel, Nafiye Yılmaz
The aim of this study is to present a very rare dermatologic condition of the vulva. Angiokeratoma is a benign dilation of ectatic thin-walled blood vessels and congested capillaries in the superficial dermal layer of skin. It occurs predominantly in men and extremely rare in women. Angiokeratoma presents as single or multiple papular lesions on the vulva with smooth or verrucous surface. These lesions are easily confused with infectious disease, inflammatory lesions, and epithelial tumors. In this report, we presented a 42 year old unmarried woman who was admitted to our clinic with complaints of two papuler lesions of the right labium majus with vaginal discharge, vulvar pruritis, and vulvar edema...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976125/in-human-alleles-specific-variation-of-mthfr-c677t-and-a1298c-associated-risk-factor-for-the-development-of-ovarian-cancer
#17
Anupama Singh, S Pandey, L K Pandey, Ajit K Saxena
Etiopathology of tumor biology is highly complex and ovarian cancer is one of the important gynaecological neoplasia associated with <b>high risk<b> of mortality rate. Methlenetetrahydrofolate reductase (MTHFR) mutation are commonly linked to folate metabolism with increased risk factor for the development of neural tube defects, recurrent pregnancy loss and development of several type of cancer but genetic interaction between two alleles of MTHFR has been poorly defined in ovarian cancer in India...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976124/prevalence-of-quid-induced-lichenoid-reactions-among-western-indian-population
#18
Jitender Solanki, Sarika Gupta
OBJECTIVE: Betel quid and areca nut chewing is widely prevalent in many parts of Asia and Asian migrant communities in the world. Due to the carcinogenicity associated with quid and areca nut we developed an interest to study the prevalence of quid induced oral lichenoid reactions in the population of western India. METHODS: A total population of 4981 males and females was screened for tobacco use and the prevalence of lesion in 86 quid users was seen. The lesions which met the selection criteria of oral lichenoid reaction were identified...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976123/immunostimulant-and-chemoprotective-effect-of-vivartana-a-polyherbal-formulation-against-cyclophosphamide-induced-toxicity-in-swiss-albino-mice
#19
Sadhana Gnanasekaran, Kunnathur Murugesan Sakthivel, Guruvayoorappan Chandrasekaran
The aim of the study is to develop a technology for cost effective immunomodulator from natural products to combat adverse effects during cancer chemotherapy. In the present study, the immunomodulatory efficacy of Vivartana, a poly herbal formulation in immunosuppressed animal model induced by cyclophosphamide (CTX) and its comparison with standard herbal immunostimulators Chyawanprash and Brahma Rasayana was investigated. The effect of Vivartana (500 mg/kg.bw) (p.o.), Chyawanprash (20 mg/kg.bw) (p.o.) and Brahma Rasayana (20 mg/kg...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28976122/role-of-telomerase-in-anticancer-activity-of-pristimerin-in-prostate-cancer-cells
#20
Yong Bo Liu, Xiaohua Gao, Dorrah Deeb, Kirit Pindolia, Subhash C Gautam
Pristimerin (PM) is a quinonemethide triterpenoid present in various plant species with strong antiprolifertive and proapoptotic activities in cancer cells. The effect of PM on telomerase which is reactivated in most cancers including carcinoma of the prostate (CaP) has not been studied. We investigated the effect of PM on the expression of human telomerase reverse transcriptase (hTERT) gene that codes for the catalytic subunit of the telomerase holoenzyme complex in prostate cancer cell lines LNCaP and PC-3 cells...
September 2017: Journal of Experimental Therapeutics & Oncology
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