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Experimental Animals

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https://www.readbyqxmd.com/read/29769463/the-kinematic-recovery-process-of-rhesus-monkeys-after-spinal-cord-injury
#1
Rui-Han Wei, Can Zhao, Jia-Sheng Rao, Wen Zhao, Xia Zhou, Peng-Yu Tian, Wei Song, Run Ji, Ai-Feng Zhang, Zhao-Yang Yang, Xiao-Guang Li
After incomplete spinal cord injury (SCI), neural circuits may be plastically reconstructed to some degree, resulting in extensive functional locomotor recovery. The present study aimed to observe the post-SCI locomotor recovery of rhesus monkey hindlimbs and compare the recovery degrees of different hindlimb parts, thus revealing the recovery process of locomotor function. Four rhesus monkeys were chosen for thoracic hemisection injury. The hindlimb locomotor performance of these animals was recorded before surgery, as well as 6 and 12 weeks post-lesion...
May 16, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29760343/acute-effect-of-ivabradine-on-heart-rate-and-myocardial-oxygen-consumption-in-dogs-with-asymptomatic-mitral-valve-degeneration
#2
Prapawadee Pirintr, Vudhiporn Limprasutr, Nakkawee Saengklub, Parnpradub Pavinadol, Napat Yapao, Natthakarn Limvanicharat, Hathaisiri Kuecharoen, Anusak Kijtawornrat
Degenerative mitral valve disease (DMVD) is a common cardiac disease in geriatric dogs characterized by the degeneration of the mitral valve, leading to decreased cardiac output and activation of the sympathetic and renin-angiotensin-aldosterone system. This disease results in an increased resting heart rate (HR) and myocardial oxygen consumption (MVO2 ). A recent publication demonstrated that dogs with asymptomatic DMVD had a significantly higher HR and systemic blood pressure (BP) than age-matched control dogs...
May 14, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29731492/phencyclidine-dose-optimisation-for-induction-of-spatial-learning-and-memory-deficits-related-to-schizophrenia-in-c57bl-6-mice
#3
Mohd Aizat Zain, Elham Rouhollahi, Vijayapandi Pandy, Vasudevan Mani, Abu Bakar Abdul Majeed, Won Fen Wong, Zahurin Mohamed
Phencyclidine (PCP) has been used to model cognitive deficits related to schizophrenia in rats and mice. However, the model in mice is not consistent in terms of the PCP effective dose reported. Furthermore, most of the previous studies in mice excluded the presence of drug washout period in the regime. Thus, we aimed to optimize the dose of PCP in producing robust cognitive deficits by implementing it in a PCP regime which incorporates a drug washout period. The regimen used was 7 days' daily injection of PCP or saline for treatment and vehicle groups, respectively; followed by 24 hours drug washout period...
May 4, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29731490/sulfasalazine-treatment-can-cause-a-positive-effect-on-lps-induced-endotoxic-rats
#4
Burak Dik, Gonca Sonmez, Hatice Eser Faki, Emre Bahcivan
The aim of this study, was to determine the effect of sulfasalazine for different periods of time reduces disseminated intravascular coagulation, inflammation and organ damages by inhibiting the nuclear factor kappa beta pathway. The study was performed with 30 Wistar albino rats and the groups were established as Control group, LPS group; endotoxemia was induced with LPS, SL5 group: sulfasalazine (300 mg/kg, single dose daily) was administered for 5 days before the LPS-induced endotoxemia, and LS group: sulfasalazine (300 mg/kg, single dose) was administered similtenously with LPS...
May 2, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29695649/stf-083010-an-inhibitor-of-xbp1-splicing-attenuates-acute-renal-failure-in-rats-by-suppressing-endoplasmic-reticulum-stress-induced-apoptosis-and-inflammation
#5
Lei Liu, Lu Xu, Shaoqing Zhang, Dong Wang, Guoxia Dong, Hanwen Chen, Xinjian Li, Chi Shu, Rong Wang
Endoplasmic reticulum (ER) stress is one of the driving forces of ischemia/reperfusion (IR)-induced acute renal failure (ARF). STF-083010, an inhibitor of the endonuclease activity of inositol-requiring enzyme-1 (IRE1), has the potential to block the initiation of a prolonged unfolded protein response (UPR) that is stimulated by ER stress and alleviates the impairments due to ER stress. In the current study, it was hypothesized that STF-083010 was capable of ameliorating ER stress-related damages in IR-induced ARF...
April 25, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29681579/a-rat-model-for-pituitary-stalk-electric-lesion-induced-central-diabetes-insipidus-application-of-3d-printing-and-further-outcome-assessments
#6
Zhanpeng Feng, Yichao Ou, Mingfeng Zhou, Guangsen Wu, Linzi Ma, Yun Bao, Binghui Qiu, Songtao Qi
A stable and reproducible rat injury model is not currently available to study central diabetes insipidus (CDI) and the neurohypophyseal system. In addition, a system is needed to assess the severity of CDI and measure the accompanying neurobiological alterations. In the present study, a 3D-printed lesion knife with a curved head was designed to fit into the stereotaxic instrument. The neuro-anatomical features of the brain injury were determined by in vivo magnetic resonance imaging (MRI) and arginine vasopressin (AVP) immunostaining on brain sections...
April 20, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29526866/relationship-between-morphological-development-and-sex-hormone-receptor-expression-of-mammary-glands-with-age-in-male-rats
#7
Yoko Miyamoto, Hiroaki Kawaguchi, Akihide Tanimoto
The aim of this study is to investigate the changes with age on morphology and sex hormone receptor expression in the mammary glands of male Sprague-Dawley rats, focusing on male-specific cells, "oxyphilic cells", observed after sexual maturity. The mammary glands of male rats at 14, 21, 35, 50, 75 and 100 days old were examined by gross observation, microscopic observation using whole mount specimens, histological and immunohistochemical sections. Grossly, mammary glands showed brown color at 50-100 days old...
March 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29526865/oxymatrine-attenuates-lipopolysaccharide-induced-acute-lung-injury-by-activating-the-epithelial-sodium-channel-and-suppressing-the-jnk-signaling-pathway
#8
Bingji Jin, Hong Jin
The epithelial sodium channel (ENaC) and mitogen-activated protein kinase (MAPK) pathway have been reported to be associated with the progression of acute lung injury (ALI). Oxymatrine (OMT) alone or combined with other drugs can ameliorate paraquat- or oleic acid-induced lung injury. However, the effect of OMT on lipopolysaccharide (LPS)-induced ALI remains unknown. The aim of the present study was to evaluate whether OMT can attenuate LPS-induced ALI through regulation of the ENaC and MAPK pathway using an ALI mouse model...
March 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29515059/subchondral-bone-derived-mesenchymal-stem-cells-display-enhanced-osteo-chondrogenic-differentiation-self-renewal-and-proliferation-potentials
#9
Hao Zhang, Zhong-Li Li, Xiang-Zheng Su, Li Ding, Ji Li, Heng Zhu
Rabbit mesenchymal stem cells (MSCs) are important seed cells in regenerative medicine research, particularly in translational research. In the current study, we showed that rabbit subchondral bone is a reliable source of MSCs. First, we harvested subchondral bone (SCB) from the rabbit knee-joint and initiated the MSC culture by cultivating enzyme-treated SCB. Adherent fibroblast-like cells that outgrew from SCB fulfill the common immuno-phenotypic criteria for defining MSCs, but with low contamination of CD45+ hematopoietic cells...
March 8, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29467352/thioacetamide-induced-hepatic-fibrosis-in-the-common-marmoset
#10
Takashi Inoue, Yukihito Ishizaka, Emi Sasaki, Jun Lu, Takayuki Mineshige, Mikio Yanase, Erika Sasaki, Masayuki Shimoda
The common marmoset (Callithrix jacchus) is a nonhuman primate that is used for preclinical research on stem cell transplantation therapies due to its similarity to human beings as well as its small size, enabling researchers to perform experiments without preparing a large number of cells. In this study, we developed a marmoset hepatic fibrosis model for regenerative medicine research. Six female marmosets aged 4-6 years were administered thioacetamide (TAA) at a dose of 2.5-40 mg/kg two or three times a week...
February 21, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29445064/the-validity-of-anesthetic-protocols-for-the-surgical-procedure-of-castration-in-rats
#11
Atsushi Tsukamoto, Natsuko Niino, Mizuho Sakamoto, Risa Ohtani, Tomo Inomata
To achieve surgical anesthesia in animal experimentation, it is necessary to select the appropriate anesthetic protocol by considering its pharmacological properties and the surgical procedure to be performed. However, few studies have investigated the validity of anesthetic protocols under surgical conditions in small rodents. The present study aimed to clarify the pharmacological properties of 4 anesthetic protocols during the surgical procedure of castration in rats. Eight-week-old male Wistar rats were anesthetized with anesthetics, including the combination of ketamine and xylazine (K/X), the combination of medetomidine, midazolam, and butorphanol (M/M/B), and isoflurane, and sevoflurane...
February 14, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29129847/effects-of-ketoconazole-on-cyclophosphamide-metabolism-evaluation-of-cyp3a4-inhibition-effect-using-the-in-vitro-and-in-vivo-models
#12
Le Yang, Chenyang Yan, Feng Zhang, Bo Jiang, Shouhong Gao, Youtian Liang, Lifeng Huang, Wansheng Chen
Cyclophosphamide (CP) is widely used in anticancer therapy regimens and 2-dechloroethylcyclophosphamide (DECP) is its side-chain dechloroethylated metabolite. N-dechloroethylation of CP mediated by the enzyme CYP3A4 yields nephrotoxic and neurotoxic chloroacetaldehyde (CAA) in equimolar amount to DECP. This study aimed to evaluate the inhibitory effect of ketoconazole (KTZ) on CP metabolism through in vitro and in vivo drug-drug interaction (DDI) research. Long-term treatment of KTZ induces hepatic injury; thus single doses of KTZ at low, middle, and high levels (10, 20, and 40 mg/kg) were investigated for pharmacokinetic DDI with CP...
February 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29046492/newly-breeding-an-inbred-strain-of-ischemia-prone-mongolian-gerbils-and-its-reproduction-and-genetic-characteristics
#13
Xiaoyan Du, Dongping Wang, Ying Li, Xueyun Huo, Changlong Li, Jing Lu, Ying Wang, Meng Guo, Zhenwen Chen
The Mongolian gerbil has been a useful laboratory animal in many research fields, especially in ischemia studies. However, due to the variation of the circle of Willis (COW), the ischemic model is unstable and various. To solve this problem, we newly established an inbred strain of gerbils, restricting breeding and keeping to F23 . The data on the breeding and growth of the animals are described in the present study. The genetic characteristics of F4 to F20 detected by microsatellite DNA and biochemical markers are also shown here...
February 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/28993564/swine-used-in-the-medical-university-overview-of-20-years-of-experience
#14
Eiji Kobayashi, Yutaka Hanazono, Satoshi Kunita
Center for Development of Advanced Medical Technology (CDAMTec) in Jichi Medical University was established in 2009. It is the first educational research facility specialized for medical research and training using swine in Japan. Preclinical studies on large animals are essential prior to clinical trials to develop regenerative medical products and medical equipment. We have continued comprehensively considering using miniature swine for experiments to develop advanced medical technologies and train physicians with advanced clinical abilities, while paying attention to animal welfare...
February 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/28855444/a-rat-model-for-studying-electroacupuncture-analgesia-on-acute-visceral-hyperalgesia
#15
De-Bo Qi, Si-Hui Zhang, Yu-Hua Zhang, Shu-Qin Wu, Wei-Min Li
The aim of this study was to establish an appropriate rat model to study the effect of electroacupuncture (EA) analgesia on acute visceral hyperalgesia. Adult rats received colorectal instillation with different concentrations of acetic acid (AA). Treatment with EA was performed for 30 min at bilateral acupoints of ST-36 and ST-37 in the hind limbs. The visceral sensation of all rats was quantified by scores of abdominal withdrawal reflex (AWR) and discharges of rectus abdominis electromyogram (EMG) in response to colorectal distension (CRD)...
February 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/28845019/progranulin-haploinsufficiency-reduces-amyloid-beta-deposition-in-alzheimer-s-disease-model-mice
#16
Masato Hosokawa, Yoshinori Tanaka, Tetsuaki Arai, Hiromi Kondo, Haruhiko Akiyama, Masato Hasegawa
Granulin (Grn) mutations were identified in familial frontotemporal lobar degeneration (FTLD) patients with TAR DNA-binding protein of 43 kd (TDP-43) pathology. Grn transcript haploinsufficiency is proposed as a disease mechanism that leads to the loss of functional progranulin (PGRN) protein. Thus, these mutations are strongly involved in FTLD pathogenesis. Moreover, recent findings indicate that Grn mutations are associated with other neurodegenerative disorders with tau pathology, including Alzheimer's disease...
February 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/28845018/loss-of-angiotensin-converting-enzyme-ii-ace2-accelerates-the-development-of-liver-injury-induced-by-thioacetamide
#17
Hsi-Tien Wu, Ya-Wen Chuang, Cheng-Pu Huang, Ming-Huang Chang
Angiotensin converting enzyme II (ACE2), an angiotensin converting enzyme (ACE) homologue that displays antagonist effects on ACE/angiotensin II (Ang II) axis in renin-angiotensin system (RAS), could play a protective role against liver damages. The purpose of this study is to investigate whether inflammation-mediated liver injury could be affected by ACE2 derived pathways in the RAS. Eight-weeks-old wild-type (WT; C57BL/6) and Ace2 KO (hemizygous Ace2-/y ) male mice were used to induce liver fibrosis by thioacetamide (TAA) administration (0, 100, and 200 mg/kg BW)...
February 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/28824049/larger-cages-with-housing-unit-environment-enrichment-improve-the-welfare-of-marmosets
#18
Takuro Yoshimoto, Eiki Takahashi, Shunji Yamashita, Kiichi Ohara, Kimie Niimi
The provision of adequate space for laboratory animals is essential not only for good welfare but accurate studies. For example, housing conditions for primates used in biomedical research may negatively affect welfare and thus the reliability of findings. In common marmosets (Callithrix jacchus), an appropriate cage size enables a socially harmonious family environment and optimizes reproductive potential. In this study, we investigated the effects of cage size on body weight (BW), behavior, and nursing succession in the common marmoset...
February 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/28757517/reproducible-insulin-secretion-from-isolated-rat-pancreas-preparations-using-an-organ-bath
#19
Asuka Morita, Motoshi Ouchi, Misao Terada, Hiroe Kon, Satoko Kishimoto, Keitaro Satoh, Naoyuki Otani, Keitaro Hayashi, Tomoe Fujita, Ken-Ichi Inoue, Naohiko Anzai
Diabetes mellitus is a lifestyle-related disease that is characterized by inappropriate or diminished insulin secretion. Ex vivo pharmacological studies of hypoglycemic agents are often conducted using perfused pancreatic preparations. Pancreas preparations for organ bath experiments do not require cannulation and are therefore less complex than isolated perfused pancreas preparations. However, previous research has generated almost no data on insulin secretion from pancreas preparations using organ bath preparations...
February 9, 2018: Experimental Animals
https://www.readbyqxmd.com/read/28757511/use-of-animal-models-for-the-imaging-and-quantification-of-angiogenesis
#20
Min Liu, Songbo Xie, Jun Zhou
Angiogenesis is the process of developing new blood vessels from the original vascular network; it is necessary for normal physiological processes, such as embryonic development and wound healing. Angiogenesis is also involved in pathological events, including myocardial ischemia and tumor growth. To investigate the molecular mechanisms of this important process, a variety of methods and models are employed. These strategies can also be used to provide insight into the etiology of angiogenesis-related diseases, thereby contributing to the development of new diagnostics and treatments...
February 9, 2018: Experimental Animals
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