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Nature Biotechnology

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https://www.readbyqxmd.com/read/28024147/genome-wide-assessment-of-sequence-intrinsic-enhancer-responsiveness-at-single-base-pair-resolution
#1
Cosmas D Arnold, Muhammad A Zabidi, Michaela Pagani, Martina Rath, Katharina Schernhuber, Tomáš Kazmar, Alexander Stark
Gene expression is controlled by enhancers that activate transcription from the core promoters of their target genes. Although a key function of core promoters is to convert enhancer activities into gene transcription, whether and how strongly they activate transcription in response to enhancers has not been systematically assessed on a genome-wide level. Here we describe self-transcribing active core promoter sequencing (STAP-seq), a method to determine the responsiveness of genomic sequences to enhancers, and apply it to the Drosophila melanogaster genome...
December 26, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/28024146/genome-wide-mapping-of-autonomous-promoter-activity-in-human-cells
#2
Joris van Arensbergen, Vincent D FitzPatrick, Marcel de Haas, Ludo Pagie, Jasper Sluimer, Harmen J Bussemaker, Bas van Steensel
Previous methods to systematically characterize sequence-intrinsic activity of promoters have been limited by relatively low throughput and the length of the sequences that could be tested. Here we present 'survey of regulatory elements' (SuRE), a method that assays more than 10(8) DNA fragments, each 0.2-2 kb in size, for their ability to drive transcription autonomously. In SuRE, a plasmid library of random genomic fragments upstream of a 20-bp barcode is constructed, and decoded by paired-end sequencing...
December 26, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/28072792/the-rise-of-the-ethical-license
#3
Christi J Guerrini, Margaret A Curnutte, Jacob S Sherkow, Christopher T Scott
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072791/first-mitochondrial-dna-transfer-go-ahead
#4
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072790/innovative-academic-startups-2016
#5
Brady Huggett
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072789/ganymed-s-claudin-win
#6
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072788/crispr-therapeutics-push-into-human-testing
#7
Cormac Sheridan
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072787/obama-signs-21st-century-cures-act
#8
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072785/mining-ancient-proteins-for-next-generation-drugs
#9
Robert A Lazarus, Friedrich Scheiflinger
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072784/concerns-over-cures
#10
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072783/after-theranos
#11
Emily Waltz
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072782/around-the-world-in-a-month
#12
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072781/where-are-the-data
#13
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072780/recent-patents-in-metagenomics
#14
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072779/will-a-trump-administration-let-sleeping-cells-lie
#15
Jonathan D Moreno
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072778/people
#16
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072777/pancreatic-islets-find-a-new-transplant-home-in-the-omentum
#17
Charles Schmidt
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072776/gut-microbiome-profiling-tests-propelled-by-customer-demand
#18
Vijay Shankar
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072775/bms-in-microbiome-immuno-oncology-deal
#19
(no author information available yet)
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28072774/car-t-s-forge-ahead-despite-juno-deaths
#20
Laura DeFrancesco
No abstract text is available yet for this article.
January 10, 2017: Nature Biotechnology
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