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Indian Journal of Medical and Paediatric Oncology

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https://www.readbyqxmd.com/read/27688618/subacute-quadriplegic-myelopathy-following-intrathecal-methotrexate
#1
Boby Varkey Maramattom, Sandeep Padmanabhan, Vivek Radhakrishnan
No abstract text is available yet for this article.
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688617/neutropenia-due-to-palbociclib-a-word-of-caution
#2
Raja Pramanik, Ranjit Kumar Sahoo, Ajay Gogia
No abstract text is available yet for this article.
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688616/early-integration-of-palliative-medicine-into-emergency-care-is-it-a-feasible-option
#3
Shrikant Atreya
Patients with advanced malignancy often experience symptoms of disease and treatment that contribute to distress and diminish their quality of life. Most of these patients present to the emergency department thus raising its importance in providing such care especially at the end of life situation. An approach that is aimed at controlling these symptoms, whether or not undergoing curative therapy, is a key feature of high-quality patient-centered care. This paper explores the potential role of palliative medicine in the emergency room and how early integration with emergency care can help improve the quality of life of patients and thus achieve better outcomes...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688615/isolated-humeral-recurrence-in-endometrial-carcinoma
#4
Santosh Kumar Devdas, Leela Digumarti, Raghunadharao Digumarti, Kunha Charan Patro, Ramakoteswararao Nutakki
Isolated skeletal metastasis in endometrial carcinoma at recurrence is very rare. We report a 52-year-old woman diagnosed to have FIGO Stage 1b, Grade 1 endometrioid adenocarcinoma, presenting with isolated distal humerus metastasis, 2 years after surgery and adjuvant radiotherapy for primary disease. Imaging, bone scintigraphy, and cytology confirmed the diagnosis of poorly differentiated metastatic adenocarcinoma. She was treated with local radiotherapy followed by six cycles of paclitaxel and carboplatin chemotherapy along with zoledronic acid, monthly...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688614/intrathecal-trastuzumab-for-leptomeningeal-carcinomatosis-in-patients-with-human-epidermal-growth-factor-receptor-2-positive-breast-cancer
#5
Seema Gulia, Sudeep Gupta, Ashish Singh
There has been recent increase in incidence of leptomeningeal carcinomatosis, possibly due to widespread use of adjuvant trastuzumab and its known poor CNS penetration. Currently there are limited therapeutic options for these patients and outcome is poor. We report two cases of women with HER2 positive breast cancer who developed leptomeningeal carcinomatosis for which they were treated with intrathecal trastuzumab in combination with systemic therapy. Both patients had rapid symptomatic benefit and radiological response and remained progression free for at least seven months...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688613/epidermal-growth-factor-receptor-mutation-in-adenocarcinoma-lung-in-a-north-indian-population-prevalence-and-relation-with-different-clinical-variables
#6
Basharat Ahmad Kasana, Waseem Raja Dar, Sheikh Aijaz Aziz, Abdul Rashid Lone, Najeeb Ullah Sofi, Imtiyaz Ahmad Dar, Muzamil Latief, Faheem Arshad, Moomin Hussain, Mir Hussain
INTRODUCTION: Lung cancer is one of the most common causes of cancer deaths worldwide. Adenocarcinoma is taking over squamous cell lung cancer as the predominant histological subtype. Several cytotoxic drugs are available for the treatment of lung cancer, but side effects limit their use. Recently, targeted therapies for cancers have come into clinical practice. AIMS AND OBJECTIVES: To determine the prevalence of epidermal growth factor receptor (EGFR) mutation in adenocarcinoma lung in a North Indian population and its relation with different clinical variables...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688612/quantification-of-telomerase-activity-in-normal-oral-mucosal-tissue-and-oral-squamous-cell-carcinoma
#7
Arpita Rai, Venkatesh G Naikmasur, Atul Sattur
BACKGROUND AND OBJECTIVE: The role of telomeres and telomerase in oral cancer is an area of much recent interest. The understanding of the role of telomere biology, the end replication problem leading to genomic instability and the reactivation of telomerase, is absolutely critical to our understanding of oral cancer, and more so, to our ability of early diagnosis and developing novel therapies and cancer prevention approaches. The aim of the present study was to quantify telomerase activity (TA) in oral squamous cell carcinoma (OSCC) and normal oral mucosa and assess the role of telomerase as diagnostic and prognostic marker of oral malignancy...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688611/bloodstream-infections-in-febrile-neutropenic-patients-at-a-tertiary-cancer-institute-in-south-india-a-timeline-of-clinical-and-microbial-trends-through-the-years
#8
K Govind Babu, D Lokanatha, K C Lakshmaiah, M C Suresh Babu, Linu A Jacob, Gita R Bhat, Harsha Vardhana, Mahua Sinha, B R Vijaykumar, B G Sumati, R S Jayshree
INTRODUCTION: Febrile neutropenia (FN) is an oncological emergency. The choice of empiric therapy depends on the locally prevalent pathogens and their sensitivities, the sites of infection, and cost. The Infectious Diseases Society of America guidelines are being followed for the management of FN in India. METHODS: This is a prospective observational study conducted at a tertiary care cancer centre from September 2012 to September 2014. OBJECTIVES: The objectives of this study were as follows: (1) To review the pattern of microbial flora, susceptibility pattern, and important clinical variables among bloodstream infections in febrile neutropenic patients with solid tumors and hematological malignancies...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688610/newly-established-stem-cell-transplant-program-100-days-follow-up-of-patients-and-its-comparison-with-published-indian-literature
#9
Aseem Kumar Tiwari, Dinesh Arora, Ravi C Dara, Pranav Dorwal, Nitin Sood, Ruchira Misra, Sunil Kumar Gupta, Vimarsh Raina, Ashok Kumar Vaid
BACKGROUND: Hematopoietic progenitor stem cell transplantation (HPSCT) is used as a standard treatment option to improve outcome in hematological and nonhematological disorders. It is important for new HPSCT program to look at its patient outcome data and compare it with the published data to evaluate the efficacy of program. AIMS: The aim was to compile and collate the patient outcome data of HPSCT and compare with published reports. MATERIALS AND METHODS: Patient demographics, indications, stem cell harvest by apheresis, dose collected, infusion, engraftment, and follow-up data were collected from hospital information system from 2010 to 2013 in a tertiary care hospital...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688609/evaluation-of-myeloid-cells-tumor-associated-tissue-eosinophils-and-mast-cells-infiltration-in-different-grades-of-oral-squamous-cell-carcinoma
#10
Priyanka Debta, Fakir Mohan Debta, Minal Chaudhary, Smita Bussari
BACKGROUND: The multifunctional involvement and infiltration of myeloid cells (tumor-associated tissue eosinophils [TATE] and mast cells) can provide a unique opportunity to define relevant effectors functions that may represent novel, therapeutic options for modulation of tumor onset/growth. AIM: Our study aimed to evaluate infiltration of myeloid cells (TATE and Mast cells) infiltration in different grades (WHO grading) of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: Total 30 cases of OSCC were selected for this study...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688608/tobacco-related-cancers-in-india-a-review-of-incidence-reported-from-population-based-cancer-registries
#11
Smita Asthana, Rakshit S Patil, Satyanarayana Labani
BACKGROUND: Tobacco related cancers (TRC) account for major share of all cancers and updated of incidence data are helpful in policy changes. The aim was to present an update of TRCs on age-adjusted incidence data and corresponding lifetime risk of developing TRC for different regions of the country. METHODS: The data for this study were obtained from published reports of 25 population-based cancer registries (PBCRs) in India. The PBCRs in different parts of India were divided into seven regions such as North, South, Central, Northeast, West, Rural West, and East...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688607/plasma-epstein-barr-virus-and-hepatitis-b-virus-in-non-hodgkin-lymphomas-two-lymphotropic-potentially-oncogenic-latently-occurring-dna-viruses
#12
Mahua Sinha, Clementina Rama Rao, C S Premalata, Mohammed Shafiulla, K C Lakshmaiah, Linu Abraham Jacob, Govind K Babu, B K Viveka, L Appaji, Jayshree R Subramanyam
CONTEXT: There is a need to study potential infective etiologies in lymphomas. Lymphocyte-transforming viruses can directly infect lymphocytes, disrupt normal cell functions, and promote cell division. Epstein-Barr virus (EBV) is known to be associated with several lymphomas, especially Hodgkin lymphomas (HLs). And recently, the lymphocyte-transforming role of hepatitis B virus (HBV) has been emphasized. AIMS: The aim of this study was to elucidate the association of two potentially oncogenic, widely prevalent latent DNA viruses, EBV and HBV, in non-HL (NHL)...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688606/hiv-associated-hematologic-malignancies-experience-from-a-tertiary-cancer-center-in-india
#13
Rakesh Reddy, Ajay Gogia, Lalit Kumar, Atul Sharma, Sameer Bakhshi, Mehar C Sharma, Saumyaranjan Mallick, Ranjit Sahoo
CONTEXT AND AIM: Data on HIV associated hematologic malignancies is sparse from India. This study attempts to analyze the spectrum and features of this disease at a tertiary cancer center in India. SETTING AND METHODS: Retrospective study from case records of patients registered with a diagnosis of hematologic malignancy and HIV infection between January 2010 and June 2015. RESULTS: Thirteen cases of HIV associated hematologic malignancies were identified, six of them pediatric...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688605/pet-ct-in-paediatric-malignancies-an-update
#14
REVIEW
Subramanyam Padma, Palaniswamy Shanmuga Sundaram, Anshu Tewari
(18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging modality in adult oncological practice. Its role in childhood malignancies needs to be discussed as paediatric malignancies differ from adults in tumor subtypes and they have different tumor biology and FDG uptake patterns. This is also compounded by smaller body mass, dosimetric restrictions, and physiological factors that can affect the FDG uptake. It calls for careful planning of the PET study, preparing the child, the parents, and expertise of nuclear physicians in reporting pediatric positron emission tomography/computed tomography (PET/CT) studies...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27688604/efficacy-and-safety-of-eribulin-mesylate-in-advanced-soft-tissue-sarcomas
#15
REVIEW
Jonathan Noujaim, Salma Alam, Khin Thway, Robin Lewis Jones
Despite recent advances in the field, treatment options for metastatic soft tissue sarcoma patients are limited. Eribulin, an antimitotic derived from the natural marine sponge product halichondrin B, is currently approved for the treatment of metastatic breast cancer. Following the promising activity of eribulin in sarcoma in a Phase II trial, the drug was recently compared to dacarbazine in pretreated advanced leiomyosarcoma (LMS) and liposarcoma (LPS) patients in a Phase III trial. Eribulin was associated with a significant 2-month improvement in median overall survival compared to dacarbazine (13...
July 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27168715/isolated-conjunctival-mass-presenting-as-acute-myeloid-leukemia-in-an-infant
#16
Akshay Gopinathan Nair, Mihir G Trivedi, Roshani J Desai, Nayana A Potdar, Ratna A Sharma, Mamta V Manglani, Chhaya A Shinde
No abstract text is available yet for this article.
April 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27168714/essential-thrombocythemia-busulphan-revisited
#17
Prasad R Koduri
No abstract text is available yet for this article.
April 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27168713/metastases-of-head-and-neck-squamous-cell-carcinoma-to-soft-tissue-of-fingertips
#18
Nishitha Shetty, M S Sameer, Hilda Fernandes, Dinesh Shet
No abstract text is available yet for this article.
April 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27168712/breast-relapse-after-metastatic-alveolar-rhabdomyosarcoma-is-it-an-incurable-entity
#19
Silvia López Iniesta, Maria Tasso Cereceda, Chevorn Suzette Adams, Carlos Esquembre Menor
Metastatic breast disease is a very rare condition in children. Rhabdomyosarcoma (RMS) is the most common solid primary tumor in children, but only a few cases of breast metastases have been described. We present the case of a young female with a primary pelvic metastatic alveolar RMS, which metastasized to the breast twice and achieved prolonged complete remission with a multimodal approach.
April 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/27168711/palmar-plantar-erythrodysesthesia-an-uncommon-adverse-effect-of-everolimus
#20
Shalabh Arora, Rajendra Akhil, Raju Titus Chacko, Renu George
Mammalian target of rapamycin inhibitor everolimus is a novel agent used in endocrine therapy resistant hormone receptor positive metastatic breast cancer. Its use has been associated with clinically significant improvement in the otherwise dismal outcomes of this subset of patients. Rash is a common adverse effect associated with everolimus. However, Hand-foot syndrome is an uncommon toxicity with the use of this drug. We report a case of Grade 3 hand-foot syndrome following institution of everolimus therapy and describe its successful management...
April 2016: Indian Journal of Medical and Paediatric Oncology
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