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Allergy and Asthma Proceedings:

James N Palmer, John C Messina, Robert Biletch, Kirk Grosel, Ramy A Mahmoud
BACKGROUND: Chronic rhinosinusitis (CRS) is believed to create a substantial population-level disease burden in the UnitedStates due to its high prevalence and significant disease morbidity, but many studies of CRS epidemiology are based onadministrative or historical record sources rather than primary population sources. OBJECTIVE: To characterize CRS symptoms, burden, and patient characteristics by using a primary U.S. population- basedrepresentative sample. METHODS: A demographically and geographically representative sample of 10,336 U...
November 14, 2018: Allergy and Asthma Proceedings:
Evan Edwards, Catherine Kessler, Naomi Cherne, Emily Dissinger, Adam Shames
BACKGROUND: Anaphylaxis in infants and young children is increasing. Historically, epinephrine auto-injectors (EAI) werenot available in a dose or platform designed for patients who weighed less than 15 kg, and, therefore, 0.15-mg EAIs were prescribed for these patients. Results of ultrasound studies indicate that currently marketed 0.15-mg EAIs have needle lengths that may strike bone in ~29 to 43% of patients who weigh less than 15 kg and result in possible intraosseous injection. An EAI with a more weight-appropriate 0...
August 29, 2018: Allergy and Asthma Proceedings:
Vicente Plaza, Jordi Giner, Myriam Calle, Paula Rytilä, Carlos Campo, Paula Ribó, Antonio Valero
Background: Asthma guidelines recommend considering patient preferences for inhaler choice. However, few studies have assessed the impact of patient satisfaction with an inhaler on adherence and health outcomes. Objective: To assess the impact of patient satisfaction with an inhaler on adherence and health outcomes in asthma. Methods: In a cross-sectional, observational, multicenter study, 778 patients with moderate or severe asthma and who were treated with maintenance inhalers completed a number of scales and questionnaires: the Feeling of Satisfaction with Inhaler (FSI-10) questionnaire, the Treatment Satisfaction Questionnaire for Medication, the Test of Adherence to Inhalers (TAI), the Morisky-Green questionnaire, and the Asthma Control Test (ACT)...
November 18, 2018: Allergy and Asthma Proceedings:
Ashraf Alzaabi, Majdy Idrees, Naser Behbehani, Musa R Khaitov, Kaan Tunceli, Eduardo Urdaneta, Nancy Awad, Mohamed Safwat
Background: Asthma is a chronic and complex lung disease that is not completely understood. It involves airway inflammation, reversible airflow obstruction, and bronchial hyperresponsiveness. The most common symptoms are recurrent wheezing, chest tightness, shortness of breath, and coughing. Objective: The Asthma Insights and Management study gathered information on the burden of asthma in the Gulf region (United Arab Emirates, Kuwait, Saudi Arabia) and Russia. Methods: This was a cross-sectional, multinational, noninterventional, two-phase study that collected data from patients ages ≥ 12 years, through interviews and a survey questionnaire...
November 16, 2018: Allergy and Asthma Proceedings:
Barbara Piekarska, Bożena L Stankiewicz-Choroszucha, Adam J Sybilski, Konrad Furmańczyk, Stanisław Jaworski, Artur Z Białoszewski, Anna Kłak, Agnieszka Lipiec, Artur Walkiewicz, Aneta Tomaszewska, Filip Raciborski, Bolesław K Samoliński
Background: Indoor air pollution may have an impact on asthma. Objective: To evaluate the influence of indoor air pollution on the natural history of asthma. Methods: Data collection by using the European Community Respiratory Health Survey and International Study of Asthma and Allergies in Childhood standardized questionnaire (N = 18,617) and medical examinations (N = 4783) in selected Polish regions was used. Statistical analysis was performed by using the χ² test. A value of p < 0.05 was considered statistically significant...
November 1, 2018: Allergy and Asthma Proceedings:
Bin Zhang, Jing Liu, Yuhao Dong, Baoliang Guo, Zhouyang Lian, Hui Yu, Xiaoning Luo, Xiaokai Mo, Lu Zhang, Wenhui Huang, Fusheng Ouyang, Xinyun Li, Changhong Liang, Shuixing Zhang
Background: Although there is good evidence that warming of contrast media changes the bolus kinetics and injection pressure of iodinated contrast media, there has been little evidence that it affects clinical adverse event rates in a meaningful way. Objective: To determine whether the extrinsic warming of low-osmolality iodinated contrast media to 37°C reduced adverse reactions. Methods: Data on adverse reactions were collected from two cohorts, one of which used contrast media at room temperature and the other in which contrast media were warmed to 37°C before administration...
November 1, 2018: Allergy and Asthma Proceedings:
Izabela Sardecka, Ewa Łoś-Rycharska, Hanna Ludwig, Julia Gawryjołek, Aneta Krogulska
Background: Cow's milk allergy (CMA) is a key form of food allergy (FA). It was shown that the frequency of FA seems to have increased during the past 10-20 years, which led to the thought that FA may have different risk factors. Epigenetic regulations and environmental pre- and postnatal factors play a large role in contributing to allergy. Understanding the risk factors that pertain to the development of FA may help to provide reasonable recommendations for prevention of the disease. Objective: To assess the impact of perinatal and environmental risk factors on the incidence of CMA in children in the first year of life...
November 1, 2018: Allergy and Asthma Proceedings:
B Piekarska, A J Sybilski, E Krzych-Fałta, K Furmańczyk, S Jaworski, A Z Białoszewski, B L Stankiewicz-Choroszucha, A Kłak, A Lipiec, B K Samoliński
No abstract text is available yet for this article.
November 1, 2018: Allergy and Asthma Proceedings:
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2018: Allergy and Asthma Proceedings:
Kristen M Lutzkanin, Erin A Davidowicz, Galen Foulke, Sheva Khalafbeigi, Alexandra Flamm, Faoud Ishmael
Although allergists often evaluate rashes associated with allergic, IgE mediated etiologies, it is important to consider a wide range of differential diagnoses that includes inflammatory, infectious, and autoimmune etiologies. The case of a 58-year-old woman with a 1-year history of progressive pruritic rash that did not improve with topical creams and steroids is presented. The patient did not state any other symptoms, and a physical examination was notable for a widespread rash. After a detailed evaluation of the rash, a differential diagnosis was made, and results of a skin biopsy confirmed a specific diagnosis...
November 1, 2018: Allergy and Asthma Proceedings:
William M Corrao
Cough alone may sometimes be the sole presenting symptom of asthma. Patients experience cough without wheeze or shortness of breath and with normal baseline pulmonary function test results. These patients do, however, demonstrate bronchial hyperreactivity. They also respond to specific traditional asthma therapy. These patients are considered to have a specific asthma phenotype: cough variant asthma (CVA).In prospective studies of patients with chronic cough, an average of 25% have CVA. Patients have chronic cough, normal baseline pulmonary function tests, positive bronchial inhalation challenge results, and response to specific asthma therapy...
November 1, 2018: Allergy and Asthma Proceedings:
Inderpal Randhawa, Tricia Morphew, Nathan L Marsteller
Background: Children with peanut allergy are regularly instructed to avoid all tree nuts. However, children with peanut allergy are likely not allergic to all tree nuts. Objective: In our cohort of patients with peanut anaphylaxis and who underwent oral immunotherapy, we sought to determine the correlation of skin-prick testing (SPT) results for tree nuts and the likelihood of successfully passing a tree nut challenge. Methods: SPT was performed for peanut and tree nuts (macadamia, pine nut, coconut, hazelnut, brazil nut, cashew, pecan, walnut, pistachio, almond) in 27 patients with known peanut allergy...
November 1, 2018: Allergy and Asthma Proceedings:
Samantha K Lin, Simin Zhang, Neelu Kalra, Gisoo Ghaffari
Background: Eosinophilic esophagitis (EoE) in patients referred to allergists can be difficult to manage. This is due to multiple factors, including overlaps in presentation with gastroesophageal reflux disease and proton-pump inhibitor responsive eosinophilia, remaining uncertainties regarding the role of different forms of allergy testing, and a variety of patient adherence issues. Objective: To highlight, in an objectively studied fashion, complications that can be faced when managing patients referred for EoE...
November 1, 2018: Allergy and Asthma Proceedings:
Nikolaos A Kitsioulis, Nikolaos G Papadopoulos, Sophia Kostoudi, Emmanouil Manousakis, Nikolaos Douladiris, Paraskevi Xepapadaki
Background: Atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) represent two of the most common chronic inflammatory pruritic skin diseases. Any relationship between atopic skin disorders and CSU is controversial, mostly due to the paucity of relevant epidemiologic and pathogenetic data. Objective: To evaluate whether a history of AD in early childhood represents a risk factor for the subsequent occurrence of CSU in a pediatric population. Methods: Retrospective data of new cases of patients who visited the outpatient allergy unit of a tertiary pediatric hospital in Athens, Greece, between June 2014 and August 2016, were analyzed...
November 1, 2018: Allergy and Asthma Proceedings:
Clifford A Reilly, Grant Backer, Danielle Basta, Natalie B V Riblet, Pamela M Hofley, Megan C Gallagher
Background: The majority of patients for elective surgery and with a history of penicillin allergy are placed on alternative prophylactic antibiotic therapies, which have been associated with the emergence of multidrug-resistant pathogens and increased morbidity and mortality rates. However, self-reporting of penicillin allergy alone may overestimate the prevalence of penicillin allergy in the population. Objective: To assess the effects of preoperative antibiotic allergy testing protocols in reducing the use of non-beta-lactam antibiotics...
November 1, 2018: Allergy and Asthma Proceedings:
Chase W Kwon, Lisa A Beck
Background: Atopic dermatitis (AD) is a common inflammatory skin disorder with a multitude of highly characterized comorbidities that affect infants, children, and adults worldwide. Despite its high prevalence and health burden, our armamentarium to treat AD in its severe form has remained lacking. For decades, the only Food and Drug Administration approved systemic treatment options for AD had been limited to corticosteroids. Methods: We conducted a nonsystematic review of the new and emerging drugs for the treatment of AD...
November 1, 2018: Allergy and Asthma Proceedings:
Brian Reed, Michael S Blaiss
Background: Atopic dermatitis (AD) is a dermatologic condition that affects a large percentage of children and adults in the United States. The disease process is not fully understood, and, currently, there is no cure, so today's treatment methodologies focus on the rash and the symptoms, e.g. , pruritus. Even though there is no mortality with this condition, there is significant morbidity and burden. Objective: This review concentrated on several areas in which AD influences quality of life. The areas include sleep, interference with daily activities (e...
November 1, 2018: Allergy and Asthma Proceedings:
Joseph A Bellanti, Russell A Settipane
No abstract text is available yet for this article.
November 1, 2018: Allergy and Asthma Proceedings:
James W Baker, Jonathan A Bernstein, Joseph R Harper, Anurag Relan, Marc A Riedl
BACKGROUND: Hereditary angioedema (HAE) may occur at or spread to multiple anatomic locations during an acute attack. Recombinant human C1 esterase inhibitor (rhC1-INH) is approved for treating acute HAE attacks. OBJECTIVE: To examine the time to the beginning of symptom relief with rhC1-INH by attack location. METHODS: Data for patients ≥12 years of age with an acute HAE attack who received rhC1-INH 50 IU/kg or placebo were pooled from two double-blind clinical trials with open-label extensions...
September 28, 2018: Allergy and Asthma Proceedings:
S David Miller, Jack Nyberg, Shahid Siddiqui, Paul Dorinsky, Earl St Rose, Colin Reisner
BACKGROUND: This is the first study of the inhaled corticosteroid, budesonide, delivered by metered-dose inhaler (BD MDI) using innovative co-suspension delivery technology in adults with asthma. OBJECTIVE: To characterize the effects of BD delivered by MDI on lung function and safety. METHODS: Randomized, double-blind, 4-week cross-over, placebo-controlled, phase IIb study of adults (18-65 years of age) with mild-to-moderate persistent asthma...
September 23, 2018: Allergy and Asthma Proceedings:
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