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Allergy and Asthma Proceedings:

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https://www.readbyqxmd.com/read/29108533/a-review-of-the-efficacy-and-safety-of-once-daily-tiotropium-respimat-2-5-micrograms-in-adults-and-adolescents-with-asthma
#1
(no author information available yet)
BACKGROUND: Despite current guidelines, many patients with asthma remain symptomatic, particularly those intolerant of,unresponsive to, or uncontrolled by long-acting beta 2-agonists (LABAs). Tiotropium bromide, delivered through the Respimatsoft-mist inhaler in 2 puffs of 1.25 micrograms each, is approved for the long-term, maintenance treatment of asthma in patients aged greater than or equal to 6 years. OBJECTIVE: An overview of the use of once-daily tiotropium Respimat 2...
November 6, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28985770/systemic-inflammation-mediates-the-detrimental-effects-of-obesity-on-asthma-control
#2
X Zhang, J Zheng, L Zhang, Y Liu, G P Chen, H P Zhang, L Wang, D Y Kang, L G Wood, G Wang
BACKGROUND: Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE: To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS: The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, which included usingThe Asthma Control Questionnaire (ACQ)-6. Obesity was defined as a body mass index (BMI) of more than or equal to 30 kg/m2, overweight was defined as BMI between 25 to 29...
October 2, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28903805/recombinant-human-c1-esterase-inhibitor-for-acute-hereditary-angioedema-attacks-with-upper-airway-involvement
#3
M A Riedl, H Li, M Cicardi, J R Harper, A Relan
BACKGROUND: Recombinant human C1 esterase inhibitor (rhC1-INH) is approved for treatment of hereditary angioedema (HAE)in adolescents and adults. HAE attacks that involve the upper airway can be life threatening, and data on the administration of rhC1-INH for these types of attacks are currently limited. OBJECTIVE: To evaluate the efficacy and safety of rhC1-INH for treatment of acute HAE attacks with upper airway involvement. METHODS: A pooled analysis of data from three clinical trials with open-label extensions examined rhC1-INH for treatmentof acute HAE attacks with upper airway involvement...
September 13, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28874235/efficacy-of-recombinant-human-c1-esterase-inhibitor-for-the-treatment-of-severe-hereditary-angioedema-attacks
#4
H H Li, A Reshef, J W Baker, J R Harper, A Relan
BACKGROUND: Severe attacks of hereditary angioedema (HAE) are debilitating and potentially life threatening, and can increase anxiety and the use of medical resources. OBJECTIVE: This post hoc assessment evaluated recombinant human C1 esterase inhibitor (rhC1-INH) used to treat acute severe HAE attacks. METHODS: In a double-blind, randomized-controlled trial (RCT), patients with an HAE attack (baseline visual analog scalescore of greater than or equal to 50 mm, with severe attacks defined as greater than or equal to 75 mm) were randomly assigned to receive rhC1-INH (50 IU/kg for patients who weighed <84 kg; 4200 IU for patients who weighed more than or equal to 84 kg) or placebo...
September 5, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28855002/health-related-quality-of-life-in-relation-to-disease-activity-in-adults-with-hereditary-angioedema-in-sweden
#5
Patrik Nordenfelt, Mats Nilsson, Anders Lindfors, Carl-Fredrik Wahlgren, Janne Björkander
BACKGROUND: Health-related quality of life (HR-QoL) is impaired in patients with hereditary angioedema (HAE) but has not yet been satisfactorily described. OBJECTIVE: To study HR-QoL in patients with HAE by combining different HR-QoL instruments with disease activity assessment. METHODS: All adults in the Swedish HAE registry were invited to take part in this questionnaire study, which used the generic HR-QoL instruments, EuroQol 5 Dimensions 5 Level (EQ-5D-5L) and the RAND Corporation Short Form 36 (RAND-36), the disease-specific Angioedema Quality of Life instrument (AE-QoL), the recently introduced Angioedema Activity Score (AAS) form, and questionnaires on sick leave and prophylactic medication...
November 30, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28800789/indicators-of-poorly-controlled-asthma-and-health-related-quality-of-life-among-school-age-children-in-the-united-states
#6
Patrick W Sullivan, Vahram Ghushchyan, Prakash Navaratnam, Howard S Friedman, Abhishek Kavati, Benjamin Ortiz, Bob Lanier
BACKGROUND: Poorly controlled asthma has far-reaching effects on school-age children and their parents, but little is known about the national impact on health-related quality of life (HRQoL). OBJECTIVE: To examine HRQoL associated with asthma and indicators of poorly controlled asthma in the United States. METHODS: This was a cross-sectional analysis of HRQoL among school-age children (age range, 6-17 years) with asthma in the nationally representative 2007-2013 Medical Expenditure Panel Survey (MEPS)...
November 11, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28886758/evaluation-of-beclomethasone-dipropionate-80-and-160-micrograms-day-delivered-via-a-breath-actuated-inhaler-for-persistent-asthma
#7
Frank C Hampel, Warner Carr, Michael Gillespie, Calvin J Small
BACKGROUND: Breath-actuated inhalers (BAI) may simplify the delivery of inhaled medications compared with other devices. OBJECTIVE: To evaluate the efficacy and safety of beclomethasone dipropionate BAI versus matching placebo in adolescent and adult patients with persistent asthma. METHODS: This phase III, 12-week, double-blind study enrolled patients with asthma aged ≥12 years who were previously treated with a stable dose of inhaled corticosteroid or noncorticosteroid therapy...
November 8, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046195/for-the-patient
#8
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046194/the-role-of-intravenous-access-during-oral-food-challenges-in-food-protein-induced-enterocolitis-syndrome
#9
Laura E Pena, Danielle Guffey, Charles G Minard, Sara Anvari, Carla M Davis
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E mediated food hypersensitivity syndrome characterized by profuse vomiting and diarrhea, which leads to lethargy, dehydration, and hypotension. Given the potential severity of reactions, resolution of FPIES is confirmed via oral food challenge (OFC) during which intravenous (IV) access is recommended to facilitate IV fluids (IVF) and steroid therapy. Risk factors for IV treatment are not well characterized...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046193/health-related-quality-of-life-in-danish-children-with-hereditary-angioedema
#10
Anne Aabom, Dan Nguyen, Niels Fisker, Anette Bygum
BACKGROUND: The potentially life-threatening disease hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) can have considerable impact on the health-related quality of life (HRQoL) in adult patients. Half the patients with C1-INH-HAE develop symptoms before the age of 10 years. However, the HRQoL in children with C1-INH-HAE is almost unexplored. OBJECTIVE: To investigate HRQoL in Danish children with C1-INH-HAE, including possible correlations to disease severity and attack frequency...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046192/management-of-adverse-reactions-to-biologic-agents
#11
Ghislaine Annie C Isabwe, Leticia de Las Vecillas Sanchez, Mariana Castells
Hypersensitivity reactions (HSR) to targeted biologic agents present as immediate reactions during infusion or as delayed reactions (after one or more exposures). The new classification includes phenotypes, endotypes, and biomarkers. Phenotypes include immediate type I (immunoglobulin E [IgE] or non-IgE mediated), cytokine release, mixed (type I/cytokine), and immune complexes type III (IgG mediated) reactions as well as delayed type IV reactions. Endotypes include IgE or non-IgE mediated mast cells/basophils activation with elevated serum tryptase and T cells values as well as macrophages, which lead to cytokine production, e...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046191/interleukin-31-and-skin-diseases-a-systematic-review
#12
Sebastiano Gangemi, Sebastiano Quartuccio, Marco Casciaro, Giovanni Trapani, Paola Lucia Minciullo, Egidio Imbalzano
BACKGROUND: Although the pathophysiology of pruritus has been extensively studied in recent years, with many resultant advancements, management of pruritus is still enigmatic, particularly in chronic cutaneous diseases, such as atopic dermatitis, chronic urticaria, allergic contact dermatitis, cutaneous T-cell lymphoma, and uremic pruritus. The recent finding of the involvement of interleukin (IL) 31 in the pathogenesis of chronic pruritus has provided a novel approach to the management of chronic inflammatory skin disorders...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046190/hereditary-angioneurotic-edema-%C3%A2-a-disease-has-been-described
#13
Joseph A Bellanti, Russell A Settipane
No abstract text is available yet for this article.
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046189/high-adherence-to-subcutaneous-immunotherapy-in-a-real-life-study-from-a-large-tertiary-medical-center
#14
Aslı Gelincik, Semra Demir, Müge Olgaç, Halim İşsever, Bayerma Khishigsuren, Ferhan Özşeker, Bahauddin Çolakoğlu, Suna Büyüköztürk
BACKGROUND: Studies on real-life adherence to subcutaneous allergen immunotherapy (SCIT) for respiratory allergy are scarce. The aim of this study was to evaluate adherence to SCIT. METHODS: The patients prescribed SCIT for allergic rhinitis and/or asthma in 2009-2011 were contacted in 2014 and asked whether they completed at least the 3 years of SCIT and/or whether they suspended the treatment for at least 2 months. The Total Symptom Score-6, visual analog scale (VAS), asthma control test (ACT), medication scores, quality of life (QoL) scores, and immunotherapy satisfaction scores with VAS obtained before the initiation of SCIT in the first year and at the end of SCIT were compared...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29046188/association-of-imbalance-of-effector-t-cells-and-regulatory-cells-with-the-severity-of-asthma-and-allergic-rhinitis-in-children
#15
Fei Huang, Jia-Ning Yin, Hong-Bo Wang, Shou-Yue Liu, Ya-Nan Li
PURPOSE: This study investigated the frequency and absolute numbers of different subsets of peripheral blood cells, including CD4+ T cells and CD19+ interleukin (IL) 10+ B regulatory cells (Breg) and their potential association with clinical laboratory measurements in children diagnosed with simple asthma or asthma plus allergic rhinitis (AR). METHOD: The frequency and numbers of peripheral blood CD4+ interferon (IFN) gamma+ T-helper (Th) type 1, CD4+ IL-4+ Th2, CD4+ IL-17A+ Th17, CD4+CD25+ Forkhead Box P3+ regulatory T cells (Treg) and CD19+ IL-10+ Bregs in 22 children with asthma, 17 children with asthma and AR, and 25 healthy controls were determined by flow cytometry...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28639542/fluticasone-propionate-and-fluticasone-propionate-salmeterol-multidose-dry-powder-inhalers-compared-with-placebo-for-persistent-asthma
#16
Lawrence D Sher, Gloria Yiu, Anat Sakov, Siyu Liu, Cynthia F Caracta
BACKGROUND: A novel, inhalation-driven, multidose dry powder inhaler (MDPI) has been developed, which allows for lower doses of fluticasone propionate (Fp) and Fp/salmeterol (FS) for the treatment of patients with asthma. OBJECTIVE: This phase III, multicenter, double-blind, parallel-group study (NCT02141854) evaluated the efficacy and safety of Fp MDPI and FS MDPI versus placebo MDPI. METHODS: Patients aged ≥12 years with persistent asthma who previously took an inhaled corticosteroid with or without a long-acting beta-agonist entered a 14- to 21-day run-in period, during which they received single-blind, low-dose Fp MDPI 50 μg (1 inhalation twice daily [b...
September 21, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28710850/efficacy-and-safety-of-beclomethasone-dipropionate-breath-actuated-or-metered-dose-inhaler-in-pediatric-patients-with-asthma
#17
Mark Vandewalker, Lisa Hickey, Calvin J Small
BACKGROUND: Breath-actuated inhalers (BAI) eliminate the need for hand-breath coordination and, therefore, simplify the delivery of inhaled medication. OBJECTIVE: To evaluate the efficacy and safety of beclomethasone dipropionate BAI and metered-dose inhaler (MDI) versus placebo in pediatric patients ages 4-11 years with persistent asthma. METHODS: In this double-blind, double-dummy, phase III study, 628 children with persistent asthma were randomly assigned (1:1:1:1:1) to twice-daily beclomethasone dipropionate (BAI 80 μg/day, BAI 160 μg/day, MDI 80 μg/day, or MDI 160 μg/day) or to placebo...
September 14, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814361/for-the-patient
#18
COMMENT
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814360/skin-rash-in-a-2-week-old-infant
#19
Marjan Nassiri, Sami L Bahna
We presented a case of a male infant with annular patchy rash on his torso since 2 weeks of age. This was initially diagnosed as tinea corporis but did not respond to oral antifungal treatment. Because of the appearance of the rash and a history of a certain disease in a maternal aunt, we suspected the most probable cause of the rash and the diagnosis was confirmed by laboratory testing. Furthermore, laboratory screening of the mother, who was asymptomatic, revealed that she was seropositive for the disease and was counseled on the importance of follow-up...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28814359/the-risk-of-autoimmune-connective-tissue-diseases-in-patients-with-atopy-a-nationwide-population-based-cohort-study
#20
Yi-Chun Hou, Hsiao-Yun Hu, I-Lin Liu, Yun-Ting Chang, Chen-Yi Wu
BACKGROUND: The relationship between autoimmune connective tissue disease (ACTD) and atopy is controversial. OBJECTIVES: To investigate the risks of ACTDs in patients with atopic triad diseases, including atopic dermatitis, allergic rhinitis, and asthma, by using a nationwide data base. METHODS: A cohort of 155,311 patients newly diagnosed with atopic dermatitis, allergic rhinitis, or asthma in 2002-2011 was obtained from the Taiwan National Health Insurance Research Database...
September 1, 2017: Allergy and Asthma Proceedings:
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