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Allergy and Asthma Proceedings:

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https://www.readbyqxmd.com/read/28120746/state-of-the-art-testing-for-alpha-1-antitrypsin-deficiency
#1
F Kueppers, C Sanders
BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition characterized by low serum levels of the proteinalpha-1 antitrypsin. Because there are no unique clinical symptoms that point to a definitive diagnosis of AATD, laboratorytesting is crucial to differentiate this disease from others. OBJECTIVE: To summarize advances in laboratory techniques used to test for AATD. METHODS: Data were sourced from a nonsystematic literature review of MEDLINE and the author's personal literature collection, and by checking reference lists of sourced articles...
January 24, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28120742/the-national-institutes-of-allergy-and-infectious-diseases-sponsored-guidelines-on-preventing-peanut-allergy-a-new-paradigm-in-food-allergy-prevention
#2
M Greenhawt
Peanut allergy is a significant public health problem without proven treatment or cure at present. In 2000, the AmericanAcademy of Pediatrics recommended that solid-food introduction be delayed in infants at high risk, including peanut introduction, until age 3 years. In 2008, the American Academy of Pediatrics revised these recommendations based on limited evidence of benefit and, instead, recommended solid-food introduction not be delayed past 4-6 months of life. In 2015, the Learning Early About Peanut Allergy study showed that early peanut introduction (between 4 and 11 months of life) was associated with a significant absolute and relative risk reduction in the development of peanut allergy compared with delayedintroduction...
January 24, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28093999/health-related-quality-of-life-with-hereditary-angioedema-following-prophylaxis-with-subcutaneous-c1-inhibitor-with-recombinant-hyaluronidase
#3
K Weller, M Maurer, M Fridman, D Supina, M Magerl, J Schranz
BACKGROUND: To estimate health-related quality-of-life changes in patients with hereditary angioedema due to C1-inhibitor (C1-INH) deficiency who received subcutaneous C1-INH with recombinant hyaluronidase (rHuPH20) for attack prophylaxis in a randomized, double-blind, dose-ranging, cross-over study. METHODS: Patients with type I/II hereditary angioedema received 1000 U of C1-INH with 24,000 U of rHuPH20 or 2000 U of C1-INH with 48,000 U of rHuPH20 every 3-4 days for 8 weeks and then crossed over for another 8-week period...
January 16, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052799/albuterol-multidose-dry-powder-inhaler-efficacy-and-safety-versus-placebo-in-children-with-asthma
#4
Craig LaForce, Herminia Taveras, Harald Iverson, Paul Shore
BACKGROUND: A novel, inhalation-driven, multidose dry powder inhaler (MDPI) that does not require coordination of actuation with inhalation has been developed. OBJECTIVE: To evaluate the efficacy and safety of albuterol MDPI versus placebo MDPI after chronic dosing in children with asthma. METHODS: This phase III, double-blind, parallel-group study included children with asthma (ages, 4-11 years) with forced expiratory volume in 1 second (FEV1) of 50-95% of predicted...
January 28, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052809/genetic-variants-of-the-gasdermin-b-gene-associated-with-the-development-of-aspirin-exacerbated-respiratory-diseases
#5
Lyoung Hyo Kim, H Chang, S Namgoong, J O Kim, H S Cheong, S-G Lee, J S Park, A R Baek, S-M Koo, I S Choi, M-K Kim, H-S Park, C-S Park, H D Shin
No abstract text is available yet for this article.
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052808/letters-to-the-editor
#6
Franco Frati, Simonetta Masieri, Cristoforo Incorvaia, Serena Buttafava, Laurent Mascarell, Philippe Moingeon
No abstract text is available yet for this article.
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052807/letters-to-the-editor
#7
Giorgio Ciprandi, Fabio Gallo, Fabio L M Ricciardolo
No abstract text is available yet for this article.
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052806/for-the-patient
#8
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052805/hypereosinophilic-syndrome
#9
Heung R Noh, Gil G Magpantay
BACKGROUND: Hypereosinophilic syndrome (HES) is a myeloproliferative disorder characterized by persistent eosinophilia associated with multiple organ damage. OBJECTIVE: To increase awareness of the rare but potentially life-threatening disease and to provide a brief overview of the clinical presentation, diagnosis, and management of HES. METHODS: Pertinent data from the patient's clinical course was incorporated with salient articles on the topic...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052804/prevalence-of-dermatologic-diseases-among-patients-with-selective-immunoglobulin-a-deficiency
#10
Eli Magen, Atheer Masalha, Dan Andrei Waitman, Natan Kahan, Igor Viner, Leonora Klassov, Daniel Vardy
BACKGROUND: There are no published large-scale epidemiologic studies regarding the prevalence of skin diseases in patients with selective immunoglobulin A (IgA) deficiency (sIgAD). The purpose of this study was to investigate the prevalence of dermatological diseases in patients with sIgAD. METHODS: This retrospective matched case-control study was based on data from the Leumit Healthcare Services data base (approximately 725,000 residents of Israel), which was searched for all subjects aged ≥12 years who had undergone serum total IgA measurements during 2004-14 for any reason...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052803/childhood-obesity-in-pediatric-patients-with-difficult-to-control-asthma-in-a-tertiary-pediatric-subspecialty-clinic
#11
Yasmin Hamzavi Abedi, Amy M Perkins, Maripaz B Morales
BACKGROUND: Identifying clinical features associated with difficult-to-control asthma will help address overall control and more-effective asthma management. OBJECTIVE: To evaluate our clinical observation that the proportion of patients who are overweight or obese is significantly higher in patients with difficult-to-control asthma than in patients with well-controlled asthma. METHODS: This was a retrospective chart review of 400 patients, ages 5 to 18 years...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052802/characteristics-of-children-with-food-protein-induced-enterocolitis-and-allergic-proctocolitis
#12
Ebru Arik Yilmaz, Ozge Soyer, Ozlem Cavkaytar, Betul Karaatmaca, Betul Buyuktiryaki, Umit M Sahiner, Bulent E Sekerel, Cansin Sackesen
BACKGROUND: The aim of this study was to determine and compare the clinical and laboratory features of food protein-induced enterocolitis syndrome (FPIES) and food protein-induced allergic proctocolitis (FPIAP), and to provide information about the short-term prognoses. METHOD: Children diagnosed with FPIES or FPIAP between 2010 and 2015 were enrolled in this study. RESULTS: Overall, 64 infants (37 FPIAP, 27 FPIES) were evaluated, with the average age at the onset of symptoms being significantly lower in the patients with FPIAP than in the patients with FPIES (2 months [1-3 months] versus 4 months [1...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052801/factors-that-determine-parents-perception-of-their-child-s-risk-of-life-threatening-food-induced-anaphylaxis
#13
Jennifer Ogg, Jayne Wong, Ming Wai Wan, Naomi Davis, Peter D Arkwright
BACKGROUND: Although food allergy is known to be associated with increased disease burden, factors that shape parents' perception of their child's risk of future severe or fatal anaphylaxis are poorly understood. OBJECTIVE: This study aimed to evaluate factors associated with parents' perceived risk of food-induced anaphylaxis. METHODS: A questionnaire-based survey of 202 parents was conducted in a single specialist center outpatient clinic that treats children with food allergies...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052800/clinical-diagnosis-and-management-of-anaphylaxis-in-infancy
#14
Emine Dibek Misirlioglu, Emine Vezir, Müge Toyran, Murat Capanoglu, Hakan Guvenir, Ersoy Civelek, Can Naci Kocabas
BACKGROUND: Anaphylaxis is increasingly reported in infancy. Diagnosis and management of anaphylaxis is difficult, and data are limited in infants. The aim of the present study was to determine the clinical course and management strategies used for anaphylaxis in infancy. METHODS: Patients attending to our clinic and who had anaphylaxis under 2 years old were evaluated. Sixty-three patients were enrolled for the study. The mean ± standard deviation age was 10.6 ± 6...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052798/diagnosis-and-management-of-allergic-conjunctivitis-in-pediatric-patients
#15
William E Berger, David B Granet, Alan G Kabat
BACKGROUND: Allergic conjunctivitis (AC), although one of the most common ocular disorders in pediatric patients, is frequently overlooked, misdiagnosed, and undertreated in children. OBJECTIVE: To guide pediatric health care professionals in the optimal diagnosis and management of AC in pediatric patients. METHODS: To identify any existing best practice guidelines for the diagnosis and treatment of AC in pediatric patients, a review of the literature published between 2004 and January 2015 was conducted...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052797/involvement-of-micrornas-in-skin-disorders-a-literature-review
#16
Carmen Mannucci, Marco Casciaro, Paola L Minciullo, Gioacchino Calapai, Michele Navarra, Sebastiano Gangemi
BACKGROUND: miRNAs are a class of noncoding RNA molecules that modulate gene expression after transcription. It is known that miRNAs are involved in various cellular processes of both normal and diseased skin. Recently, differential expressions of miRNAs have been reported and associated with several immunologic and inflammatory disorders, which indicate a common role in fundamental biologic processes. OBJECTIVE: To collect and review data from the literature on involvement of miRNA in inflammatory skin disorders...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052796/genetic-variants-of-the-gasdermin-b-gene-associated-with-the-development-of-aspirin-exacerbated-respiratory-diseases
#17
Lyoung Hyo Kim, HunSoo Chang, Suhg Namgoong, Ji On Kim, Hyun Sub Cheong, Seo-Gyeong Lee, Jong Sook Park, Ae Rin Baek, So-My Koo, Inseon S Choi, Mi-Kyeong Kim, Hea-Sim Park, Choon-Sik Park, Hyoung Doo Shin
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by a severe and sudden asthma attack after aspirin ingestion in patients with asthma. We studied associations with six common single nucleotide polymorphisms (SNP) of the gasdermin B gene (GSDMB). OBJECTIVE: DNA obtained from 572 patients with asthma (with AERD, n = 165; and with aspirin-tolerant asthma, n = 407) and 391 normal controls was subjected to genotyping of six SNPs of GSDMB. METHODS: An association analysis between GSDMB variants and AERD, with a fall rate of the forced expiratory volume in the first second of expiration (FEV1), was performed by using logistic and regression models...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052795/letters-to-the-editor
#18
Franco Frati, Simonetta Masieri, Cristoforo Incorvaia, Serena Buttafava, Laurent Mascarell, Philippe Moingeon
No abstract text is available yet for this article.
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052794/atopic-dermatitis-burden-of-illness-quality-of-life-and-associated-complications
#19
Aaron M Drucker
BACKGROUND: Atopic dermatitis is a chronically relapsing inflammatory skin condition that is burdensome for individuals with the disease, their families, and for society as a whole. OBJECTIVES: The purpose of this review was to provide a broad overview of the burden of atopic dermatitis, including quality of life and its associated complications. METHODS AND RESULTS: This article was divided into four main sections: (1) atopic dermatitis prevalence, persistence, and population-level burden; (2) burden of atopic dermatitis for individuals and their families; (3) medical complications and comorbidities of atopic dermatitis; and (4) assessment of the burden of atopic dermatitis in clinical practice...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052793/-i-ve-got-you-under-my-skin-a-challenge-for-both-the-allergist-and-the-patient
#20
Joseph A Bellanti, Russell A Settipane
No abstract text is available yet for this article.
January 1, 2017: Allergy and Asthma Proceedings:
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