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Allergy and Asthma Proceedings:

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https://www.readbyqxmd.com/read/28120746/state-of-the-art-testing-for-alpha-1-antitrypsin-deficiency
#1
REVIEW
Friedrich Kueppers, Christopher Sanders
BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition characterized by low serum levels of the protein alpha-1 antitrypsin. Because there are no unique clinical symptoms that point to a definitive diagnosis of AATD, laboratory testing is crucial to differentiate this disease from others. OBJECTIVE: To summarize advances in laboratory techniques used to test for AATD. METHODS: Data were sourced from a nonsystematic literature review of MEDLINE and the author's personal literature collection, and by checking reference lists of sourced articles...
March 24, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28120742/the-national-institutes-of-allergy-and-infectious-diseases-sponsored-guidelines-on-preventing-peanut-allergy-a-new-paradigm-in-food-allergy-prevention
#2
Matthew Greenhawt
Peanut allergy is a significant public health problem without proven treatment or cure at present. In 2000, the American Academy of Pediatrics recommended that solid-food introduction be delayed in infants at high risk, including peanut introduction, until age 3 years. In 2008, the American Academy of Pediatrics revised these recommendations based on limited evidence of benefit and, instead, recommended solid-food introduction not be delayed past 4-6 months of life. In 2015, the Learning Early About Peanut Allergy study showed that early peanut introduction (between 4 and 11 months of life) was associated with a significant absolute and relative risk reduction in the development of peanut allergy compared with delayed introduction...
March 24, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28093999/health-related-quality-of-life-with-hereditary-angioedema-following-prophylaxis-with-subcutaneous-c1-inhibitor-with-recombinant-hyaluronidase
#3
RANDOMIZED CONTROLLED TRIAL
Karsten Weller, Marcus Maurer, Moshe Fridman, Dylan Supina, Jennifer Schranz, Markus Magerl
BACKGROUND: To estimate health-related quality-of-life changes in patients with hereditary angioedema due to C1-inhibitor (C1-INH) deficiency who received subcutaneous C1-INH with recombinant hyaluronidase (rHuPH20) for attack prophylaxis in a randomized, double-blind, dose-ranging, cross-over study. METHODS: Patients with type I/II hereditary angioedema received 1000 U of C1-INH with 24,000 U of rHuPH20 or 2000 U of C1-INH with 48,000 U of rHuPH20 every 3-4 days for 8 weeks and then crossed over for another 8-week period...
March 16, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234054/for-the-patient
#4
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234053/a-randomized-study-of-bi-671800-a-crth2-antagonist-as-add-on-therapy-in-poorly-controlled-asthma
#5
RANDOMIZED CONTROLLED TRIAL
David Miller, Chester Wood, Eric Bateman, Craig LaForce, Jon Blatchford, James Hilbert, Abhya Gupta, Andrew Fowler
BACKGROUND: Asthma is characterized by a complex interaction of inflammatory mediators. The prostaglandin D2 receptor, chemoattractant receptor-homologous molecule on Th2 cells (CRTH2), plays a pivotal role in the pathogenesis of allergic airway inflammation. OBJECTIVE: To ealuate the efficacy, safety, and pharmacokinetics of BI 671800, a CRTH2 antagonist, when added to inhaled corticosteroid therapy in adult patients with symptomatic asthma. METHODS: In this phase IIa, 12-week, randomized, double-blind, three-period, four-treatment, incomplete block crossover trial, BI 671800 was administered either as a single 400-mg dose in the morning (A...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234052/what-accounts-for-the-association-between-late-preterm-births-and-risk-of-asthma
#6
Gretchen A Voge, William A Carey, Euijung Ryu, Katherine S King, Chung-Il Wi, Young J Juhn
BACKGROUND: Although results of many studies have indicated an increased risk of asthma in former late preterm (LPT) infants, most of these studies did not fully address covariate imbalance. OBJECTIVE: To compare the cumulative frequency of asthma in a population-based cohort of former LPT infants to that of matched term infants in their early childhood, when accounting for covariate imbalance. METHODS: From a population-based birth cohort of children born 2002-2006 in Olmsted County, Minnesota, we assessed a random sample of LPT (34 to 36 6/7 weeks) and frequency-matched term (37 to 40 6/7 weeks) infants...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234051/the-persistence-of-chronic-spontaneous-urticaria-in-childhood-is-associated-with-the-urticaria-activity-score
#7
Ebru Arik Yilmaz, Betul Karaatmaca, Pinar Gur Cetinkaya, Ozge Soyer, Bulent E Sekerel, Umit Murat Sahiner
BACKGROUND: There is little information regarding the etiology and natural course of chronic spontaneous urticaria (CSU) in childhood. OBJECTIVE: To investigate the etiology, prognosis, and the factors associated with the prognosis of CSU in children. METHOD: Data from children with CSU who had been diagnosed between 1992 and 2015 were analyzed. A telephone interview was done to assess the current status of these patients. Remission was defined as the disappearance of urticaria for >6 months...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234050/relation-of-indoor-and-outdoor-airborne-fungal-spore-levels-in-the-kansas-city-metropolitan-area
#8
David Jara, Jay Portnoy, Minati Dhar, Charles Barnes
BACKGROUND: Environmental control is an important component of asthma management for persons with asthma. A damp indoor environment and elevated airborne spore levels are factors in housing environmental control. OBJECTIVES: We investigated if indoor airborne fungal spore levels correlated with outdoor ground-level airborne fungal spores or outdoor centrally collected spore levels as to types and abundance. METHODS: Air collections were taken from home interiors, outdoor areas adjacent to the homes, and at a central location in the metropolitan area at the approximate same time...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234049/american-academy-of-asthma-allergy-immunology-membership-experience-with-venom-immunotherapy-in-chronic-medical-conditions-and-pregnancy-and-in-young-children
#9
Christopher W Calabria, David W Hauswirth, Matthew Rank, Lawrence Sher, Desiree Larenas-Linnemann
BACKGROUND: Few data exist regarding the use of venom immunotherapy (VIT) in specific high-risk chronic medical conditions and pregnancy, and in young children. METHODS: A Web-based survey was sent to American Academy of Asthma Allergy & Immunology members to explore their VIT experience in potential high-risk medical conditions and pregnancy, and in young children. Major problems were defined as "activation of underlying disease and/or VIT not well tolerated (systemic adverse events) and/or VIT discontinued for medical reasons...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234048/allergen-immunotherapy-at-university-health-services-and-allergist-s-reasons-for-guidelines-nonadherence
#10
Marilyn Karam, Christine Holland, Zi Yang, Kiela Samuels, Georgiana Sanders
BACKGROUND: Our previous pilot study conducted at the University of Michigan Health Services showed that fewer than 25% of the non-university allergen immunotherapy (AIT) prescribers adhered to AIT labeling guidelines which impacted both patients and healthcare personnel involved in AIT administration. OBJECTIVES: We expand our study to characterize AIT labeling compliance and impact of practice variability at the "Big 10" University Health Services, and investigate prescribers motives for nonadherence to practice parameter guidelines...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234047/understanding-alpha-1-antitrypsin-deficiency-a-review-with-an-allergist-s-outlook
#11
REVIEW
Maria Paula Henao, Timothy J Craig
Alpha-1 antitrypsin (AAT) is the prototypical protease inhibitor from the serine protease inhibitor (serpin) superfamily that protects lung tissue from proteolytic damage by inhibiting neutrophil elastase. Approximately 1 in 2750 to 1 in 4500 individuals have an autosomal codominant condition that leads to a deficiency of circulating AAT. In individuals with AAT deficiency (AATD), AAT is retained in liver cells, which predisposes them to liver disease, and does not reach lung tissues through circulation, where it normally acts as the primary natural regulator of proteolytic activity in the pulmonary tissues, which thus leads to lung disease...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234046/the-emotional-social-and-financial-burden-of-food-allergies-on-children-and-their-families
#12
REVIEW
Nilamben Patel, Linda Herbert, Todd D Green
BACKGROUND: As the prevalence of food allergy has risen among children and young adults, both in the United States and around the world, investigators have become increasingly aware of the daily emotional toll on patients and their families of living with food allergy. OBJECTIVE: To review the literature regarding the emotional, social, and financial impact of food allergy on pediatric patients and their families, and to provide evidence-based suggestions for clinicians on how to most effectively address these issues...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234045/can-the-burden-of-disease-due-to-food-allergy-be-prevented
#13
Joseph A Bellanti, Russell A Settipane
No abstract text is available yet for this article.
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234044/erratum
#14
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234043/erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234042/erratum
#16
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28234041/response-to-inhaled-corticosteroids-on-serum-cd28-quality-of-life-and-peak-expiratory-flow-rate-in-bronchial-asthma
#17
Anubhuti Gupta, Lalit K Gupta, Harmeet S Rehan, Anupam Prakash
BACKGROUND: CD28 is a 44 kDa glycoprotein that is important in initiating T-cell responses and that results in increased T-cell proliferation and interleukin-2 production. This study estimated the serum CD28 levels in patients with asthma and evaluated the effect of inhaled corticosteroids (ICS) on the levels of CD28, the peak expiratory flow rate (PEFR), and quality of life (QOL). METHODS: This prospective, open-label, observational study enrolled 40 adult patients with asthma of mild-to-moderate severity who were started on ICS and 40 healthy controls...
March 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052799/albuterol-multidose-dry-powder-inhaler-efficacy-and-safety-versus-placebo-in-children-with-asthma
#18
RANDOMIZED CONTROLLED TRIAL
Craig LaForce, Herminia Taveras, Harald Iverson, Paul Shore
BACKGROUND: A novel, inhalation-driven, multidose dry powder inhaler (MDPI) that does not require coordination of actuation with inhalation has been developed. OBJECTIVE: To evaluate the efficacy and safety of albuterol MDPI versus placebo MDPI after chronic dosing in children with asthma. METHODS: This phase III, double-blind, parallel-group study included children with asthma (ages, 4-11 years) with forced expiratory volume in 1 second (FEV1) of 50-95% of predicted...
January 28, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052808/letters-to-the-editor
#19
Franco Frati, Simonetta Masieri, Cristoforo Incorvaia, Serena Buttafava, Laurent Mascarell, Philippe Moingeon
No abstract text is available yet for this article.
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052807/letters-to-the-editor
#20
Giorgio Ciprandi, Fabio Gallo, Fabio L M Ricciardolo
No abstract text is available yet for this article.
January 1, 2017: Allergy and Asthma Proceedings:
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