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Allergy and Asthma Proceedings:

(no author information available yet)
BACKGROUND: Chronic idiopathic urticaria (CIU)/spontaneous urticaria (CSU) is defined by the presence of wheals,angioedema, or both for 6 weeks, with or without an identifiable trigger. Real-world health care data among children withCIU/CSU remain scarce. OBJECTIVES: To describe treatment patterns, health care resource utilization (HRU), and costs in pediatric patients with CIU/CSU (12 years old) and to compare these with pediatric patients without CIU/CSU. METHODS: A commercial administrative claims data base (September 2013 to June 2016) was used...
March 7, 2018: Allergy and Asthma Proceedings:
(no author information available yet)
BACKGROUND: Omalizumab was approved for the treatment of chronic idiopathic urticaria (CIU)/chronic spontaneous urticaria (CSU) in the United States in March 2014. OBJECTIVE: This study sought to describe real-world omalizumab use, in the United States, in a large cohort of patients withCIU/CSU. METHODS: Patients with CIU/CSU (ages greater than or equal to 12 years) initiated on omalizumab (index date) with greater than or equal to 12 months of pre- and postindex data were identified in the an insurance claims data base (January 1, 2013, to July 31, 2016)...
February 19, 2018: Allergy and Asthma Proceedings:
(no author information available yet)
BACKGROUND: Breath-actuated inhalers (BAI) eliminate the need for the hand-breath coordination required with standardmetered-dose inhalers (MDI). OBJECTIVE: To evaluate the efficacy and safety of beclomethasone dipropionate (BDP) administered via BAI. METHODS: This 6-week, phase III, double-blind study included patients aged greater than or equal to 12 years with persistent asthma. During the single-blind run-in, patients discontinued asthma medications and received twice-daily placebo BAI or MDI...
January 9, 2018: Allergy and Asthma Proceedings:
Martha V White
BACKGROUND: Without securing a child properly, injuries can happen with the use of pediatric epinephrine autoinjectors (EAI), and lacerations and embedded needles have been reported. Health care providers should ensure that instruction is provided to parents on how to hold a child during an injection with an EAI. OBJECTIVE: To demonstrate the compassionate restraint of small children during an allergic emergency to ensure the safe use of an EAI. METHODS: A patient was used to illustrate a compassionate restraint technique during a mock injection with an EAI...
March 29, 2018: Allergy and Asthma Proceedings:
Mi-Hee Lee, Hye-Jin Seo, Eun Ju Shin, Youn Kyoung Won, Yu Mi Jung, Seung-Hee Suh, Jin-Young Jeong, Young Shil Lim, You Young Kim, Eun Hee Chung
BACKGROUND: Understanding the patterns of emergency department (ED) visits of patients with asthma is important for disease control and prevention of exacerbations. OBJECTIVE: This study aimed to investigate the characteristics of adult patients who visited EDs because of their asthma. METHODS: Patients with asthma, ages ≥19 years old, who visited 117 EDs throughout Korea between January 2007 and December 2012 were identified in the National Emergency Department Information System (NEDIS) data base using the International Classification of Disease, 10th revision, codes J45 (asthma) and J46 (status asthmaticus)...
March 28, 2018: Allergy and Asthma Proceedings:
Dominic Pilon, Abhishek Kavati, Benjamin Ortiz, Brandee Paknis, Ashok Vegesna, Bradd Schiffman, Maryia Zhdanava, Patrick Lefebvre, Brian Stone
BACKGROUND: Omalizumab is approved in patients with moderate-to-severe allergic asthma with symptoms uncontrolled, despite the mainstay therapy. OBJECTIVE: Electronic medical records (EMR) were used to increase the knowledge of omalizumab effectiveness in a real-world setting. METHODS: Patients with uncontrolled moderate-to-severe allergic asthma, ages ≥12 years old, initiated on omalizumab (index date), with ≥12 months of pre- and postindex data, were identified in an EMR data base...
March 5, 2018: Allergy and Asthma Proceedings:
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2018: Allergy and Asthma Proceedings:
Anastasia I Petra, Irene Tsilioni, Alexandra Taracanova, Alexandra Katsarou-Katsari, Theoharis C Theoharides
BACKGROUND: Cytokine interleukin (IL) 31 has emerged as an important component of allergic and inflammatory diseases associated with pruritus, such as atopic dermatitis (AD) and mastocytosis. Mast cells (MC) are stimulated by allergic and nonallergic triggers, and play a critical role in such diseases by secreting histamine and tryptase as well as cytokines and chemokines. IL-33 has been reported to augment MC responses, but its effect on secretion of IL-31 is not known. OBJECTIVES: To investigate whether IL-33 can stimulate the secretion of IL-31 from cultured human MCs and whether this response is augmented by either the neuropeptide substance P (SP) or immunoglobulin E (IgE) and anti-IgE in the absence or presence of IL-4...
March 1, 2018: Allergy and Asthma Proceedings:
Oliver J Lawless, Joseph A Bellanti, Milton L Brown, Kathryn Sandberg, Jason G Umans, Li Zhou, Weiqian Chen, Julie Wang, Kan Wang, Song Guo Zheng
BACKGROUND: Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25+ Forkhead box P3-positive (FOXP3+) T regulatory (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative effort to find ways of increasing Tregs as a method of therapy for these conditions. One such line of investigation includes the study of how ligation of Toll-like receptors (TLRs) by CpG oligonucleotides (ODN) results in an immunostimulatory cascade that leads to induction of T-helper (Th) type 1 and Treg-type immune responses...
March 1, 2018: Allergy and Asthma Proceedings:
William Berger, Ellen Sher, Sandra Gawchik, Stanley Fineman
BACKGROUND: The safety of a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) has been established in adults and adolescents with allergic rhinitis but not in children <12 years old. OBJECTIVE: To evaluate the safety and tolerability of an intranasal formulation of AZE and FP in children ages 4-11 years with allergic rhinitis. METHODS: The study was a randomized, 3-month, parallel-group, open-label design...
March 1, 2018: Allergy and Asthma Proceedings:
Jian Wang, Rui Ke, Wenhua Shi, Xin Yan, Qingting Wang, Qianqian Zhang, Limin Chai, Manxiang Li
BACKGROUND: Psoriasis has been shown to be related to an increased risk of asthma, although the results remain inconclusive. Therefore, we performed a meta-analysis to determine whether psoriasis increases the risk of asthma. METHODS: A comprehensive search of medical literature data bases was conducted through May 2017. The pooled odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated. RESULTS: A total of six studies with 66,772 psoriasis cases and 577,415 controls were included...
March 1, 2018: Allergy and Asthma Proceedings:
Eli Magen, Tinatin Chikovani, Dan-Andrei Waitman, Natan R Kahan
BACKGROUND: Epidemiologic studies report that alopecia areata (AA) is related to various atopic and autoimmune diseases. The purpose of this study was to identify clinical characteristics and the prevalence of comorbid conditions in Israeli patients with AA. METHODS: This retrospective, matched, case-control study was based on data from an electronic patient record data base. The patients with an electronically documented diagnosis of AA were included in the AA group...
March 1, 2018: Allergy and Asthma Proceedings:
Paola L Minciullo, Antonio Cascio, Sebastiano Gangemi
BACKGROUND: The association between parasites and urticaria was first suggested in the last century. A wide range, 0-75.4%, of the prevalence of parasitic infection has been reported with chronic urticaria (CU). Moreover, urticaria may be detected in patients with parasitosis. Nematodes are a type of helminth that infect hundreds of millions of people throughout the world. OBJECTIVE: The aim of this work was to collect and review the published studies and cases of urticaria associated with nematode infections...
March 1, 2018: Allergy and Asthma Proceedings:
Joseph A Bellanti, Russell A Settipane
No abstract text is available yet for this article.
March 1, 2018: Allergy and Asthma Proceedings:
Eli O Meltzer, William E Berger
BACKGROUND: Despite current guidelines, many patients with asthma remain symptomatic, particularly those intolerant of, unresponsive to, or uncontrolled by long-acting beta 2-agonists (LABAs). Tiotropium bromide, delivered through the Respimat soft-mist inhaler in 2 puffs of 1.25 micrograms each, is approved for the long-term, maintenance treatment of asthma in patients aged ≥6 years. OBJECTIVE: An overview of the use of once-daily tiotropium Respimat 2.5 micrograms in adults and adolescents with varying degrees of asthma severity...
January 6, 2018: Allergy and Asthma Proceedings:
Xin Zhang, Jing Zheng, Li Zhang, Ying Liu, Gai Ping Chen, Hong Ping Zhang, Lei Wang, De Ying Kang, Lisa G Wood, Gang Wang
BACKGROUND: Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE: To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS: The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, which included using The Asthma Control Questionnaire (ACQ)-6. Obesity was defined as a body mass index (BMI) of ≥30 kg/m2, overweight was defined as BMI between 25 to 29...
January 2, 2018: Allergy and Asthma Proceedings:
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2018: Allergy and Asthma Proceedings:
Jaison Jose, Erik B Lehman, Timothy Craig
BACKGROUND: Ever-expanding armamentarium of treatments for hereditary angioedema (HAE) are associated with various adverse effects, issues with vascular access, or lack of self-administration. OBJECTIVE: To understand patients' impressions and confidence in their past and present treatments, and identifying adverse events while also directly asking patients to reveal their hope for the future of HAE management and treatments. METHODS: After institutional review board approval, all subjects with laboratory-confirmed HAE were mailed a survey that they completed and returned to the researchers, and data were collected and entered into a secure online web application for surveys...
January 1, 2018: Allergy and Asthma Proceedings:
Joanna Jerzynska, Wlodzimierz Stelmach, Pawel Majak, Rafal Stelmach, Anna Janas, Iwona Stelmach
BACKGROUND: One of the most important aspects of sublingual immunotherapy (SLIT) is the regimen of administration. AIM: To find any differences in symptom-medication scores between the two groups of SLIT tablets and drops, given pre-coseasonally (starting 8 weeks before the pollen season) in children with rhinoconjunctivitis allergy to grass pollen. The secondary outcome were the differences in lung function and induction of T-regulatory forkhead box P3 (FOXP3) positive cells...
January 1, 2018: Allergy and Asthma Proceedings:
Zekiye İlke Kılıç Topçu, Neşe Kaklıkkaya, Ali Baki, Fazıl Orhan
BACKGROUND: The prevalence of immunoglobulin E (IgE) mediated beef allergy in childhood is unknown. We investigated the prevalence and characteristics of IgE-mediated beef allergy in urban schoolchildren. METHODS: This cross-sectional study recruited 6000 randomly selected urban schoolchildren ages 6-17 years from the city center of Giresun in the eastern Black Sea region of Turkey during 2013. Children with suspected IgE-mediated beef allergy, determined by a self-administered questionnaire, after providing written consent, were skin-prick tested with commercial beef and cow's milk solutions and prick-prick tested with raw, boiled, and fried beef...
January 1, 2018: Allergy and Asthma Proceedings:
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