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Current Pharmaceutical Design

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https://www.readbyqxmd.com/read/28530544/the-second-generation-of-highly-potent-hepatitis-c-virus-hcv-ns3-4a-protease-inhibitors-evolutionary-design-based-on-tailor-made-amino-acids-synthesis-and-major-features-of-bio-activity
#1
Shuni Wang, Yibing Wang, Jiang Wang, Tatsunori Sato, Kunisuke Izawa, Vadim A Soloshonok, Hong Liu
Hepatitis C is a current pandemic liver disease caused by the hepatitis C virus (HCV) with high morbidity and mortality. Recently, the direct-acting antiviral agents (DAAs) targeting HCV NS3/4A, NS5A and NS5B have become the most effective therapies against HCV infection in the clinical treatment. Among them, the second-generation of NS3/4A inhibitors have emerged as the mainstay of the DAA therapies, which are derived from the peptide substrate of NS3/4A protease and modified with various tailor-made amino acids in order to achieve high sustained virologic response (SVR) against HCV...
May 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28530543/using-properties-of-tumor-microenvironments-for-controlling-local-on-demand-delivery-from-biopolymer-based-nanocarriers
#2
Abdullah K Alshememry, Suleiman S El-Tokhy, Larry D Unsworth
BACKGROUND: The 'tumor microenvironment' comprised of tumor cells, non-malignant stromal tissues, signaling molecules and the extracellular matrix. Tumor microenvironment has unique physical and physiological characteristics including vascular abnormalities, hypoxia, acidic pH, specific enzymes and growth factors upregulation and high reducing potential. It is these endogenous properties of the tumor environment that can be used to trigger the release of cancer therapeutics both locally and as a function of disease state...
May 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28521695/biomorphic-ceramics-for-drug-delivery-in-bone-tissue-regeneration
#3
Patricia Diaz-Rodriguez, Mariana Landin
Incorporating therapeutic molecules into biomorphic ceramics for in situ drug release can be used to generate novel systems for tissue regeneration. These systems couple the complex hierarchical porous structures of biomorphic ceramics with the therapeutic activity of drugs. There are a large number of natural precursors available to be used as templates to obtain biomorphic silicon carbide ceramics. Additionally, different drug loading techniques can be used for these systems. The high versatility in structures and drugs allows the selection of the right structure-drug fit in each case according to the tissue needs...
May 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28521694/bioresponsive-injectable-hydrogels-for-on-demand-drug-release-and-tissue-engineering
#4
Arti Vashist, Ajeet Kaushik, Kayla Alexis, Rahul Dev Jayant, Vidya Sagar, Atul Vashist, Madhavan Nair
The emergence of injectable hydrogels as biomaterials has been a revolutionary breakthrough in the field of on-demand drug delivery and tissue engineering. The promising features of these systems include their biodegradability, biocompatibility, permeability, ease of the surgical implantation, and most importantly exhibit minimally invasiveness. These hydrogels have been explored as sustained and on demand release carriers for the various bioactive agents, growth factors, live cells, various hydrophobic drugs and as extracellular matrices for tissue engineering...
May 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28521693/from-tendon-injury-to-collagen-based-tendon-regeneration-overview-and-recent-advances
#5
Clément Rieu, Lise Picaut, Gervaise Mosser, Léa Trichet
Tendon injury is a clinical, societal and economical issue. Moreover, tendon repair represents an important clinical challenge, partly due to the mechanical constraints that occur at the junctions with muscle and bone. Several strategies have been developed for tendon repair. In this review, we first assess the importance of tendon injuries from different sites and their causes. After a short overview of tendon three-dimensional organization, the complexity of the perfect repair quest is presented ranging from current clinical procedures to new engineering scaffolds...
May 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28521692/pharmacological-treatment-of-bone-loss
#6
Rui Pang, Weibo Xia
Bone loss is common in clinical practice, such as health assessment of postmenopausal women, treatment of tumor metastasis, side-effects of glucocorticoids, and skeletal manifestations of inflammatory diseases. The imbalance of remodeling between bone resorption and bone formation, the pathophysiological basis of bone loss, increases bone fragility. The treatment of bone loss is mainly carried out from the treatment of osteoporosis. There are various pharmacological therapies for bone loss, which will be introduced in 3 aspects, including anti-resorptive agents, anabolic agents and new medications...
May 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28521691/prospect-of-combination-and-sequential-therapies-for-postmenopausal-osteoporosis
#7
Hao Liu, Binbin Li
BACKGROUND: Osteoporosis is a systemic bone disease, which is associated with the osteoporotic fracture. Along with prolonged life expectancy, the fracture risk increases dramatically with age. So far, it is usually the first choice to using antiresorptive agents. However, current clinical therapeutic treatments are not enough to inhibit the long-term bone loss and the rising risk of bone fractures. Recently, sequential and combination therapies with anti-osteoporosis drugs have become an inevitable trend...
May 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28521690/engineered-bone-tissue-with-naturally-derived-small-molecules
#8
Guleid Awale, Edgar Wong, Komal Rajpura, Kevin W-H Lo
Natural products remain the best resources of drugs and drug leads. Recently, there is growing recognition that identifying new small molecules to promote bone regeneration is a laudable translational goal. In fact, new approaches for bone repair and regeneration that involve inexpensive naturally-derived compounds would have an important impact on the treatment of bone disorders and injuries. Over the past several decades, a number of naturally-derived small molecules with the potential of regenerating bone tissue (i...
May 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28494718/osteoimmunology-offers-new-perspectives-for-the-treatment-of-pathological-bone-loss
#9
Hongrui Liu, Tingting Luo, Jiali Tan, Minqi Li, Jie Guo
New evidence of the interactions between the immune system and bone has accumulated in bone diseases, including osteoporosis, periodontitis and rheumatoid arthritis. A marked imbalance between bone resorption and formation is central to the onset of pathological bone loss. Osteoimmunology has revealed that the immune system, including T cells, B cells and inflammatory cytokines, is a key regulator of both osteoclasts and osteoblasts. Th1 cells, which differentiate from CD4+T cells, are thought to play a major function during bone loss...
May 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28494717/gelatin-as-biomaterial-for-tissue-engineering
#10
Mari Carmen Echave, Laura Saenz Del Burgo, Jose Luis Pedraz, Gorka Orive
Tissue engineering is considered one of the most important therapeutic strategies of regenerative medicine. The main objective of these new technologies is the development of substitutes made with biomaterials that are able to heal, repair or regenerate injured or diseased tissues and organs. These constructs seek to unlock the limited ability of human tissues and organs to regenerate. In this review, we highlight the convenient intrinsic properties of gelatin for the design and development of advanced systems for tissue engineering...
May 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28521709/modulation-of-inflammatory-response-to-implanted-biomaterials-using-natural-compounds
#11
Maria Yanez, James Blanchette, Ehsan Jabbarzadeh
Tissue engineering offers a promising strategy to restore injuries resulting from trauma, infection, tumor resection, or other diseases. In spite of significant progress, the field faces a significant bottleneck; the critical need to understand and exploit the interdependencies of tissue healing, angiogenesis, and inflammation. Inherently, the balance of these interacting processes is affected by a number of injury site conditions that represent a departure from physiological environment, including reduced pH, increased concentration of free radicals, hypoglycemia, and hypoxia...
May 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28494716/gender-medicine-and-pharmacoeconomics-a-narrative-review-of-the-international-literature-of-the-last-5-years-a-revision-of-evidences-about-the-relationship-between-gender-and-economic-consumption-in-health
#12
Delia Colombo, Lucia Simoni, Emanuela Zagni
Introduction The influence of patient gender on the economic impact of health care has increasingly been examined in the recent literature. Gender appears to have an impact on healthcare resource consumption, due to possible differences in the patient's response to a chosen therapeutic management strategy or to a healthcare intervention. Objective The present work is aimed at collecting and reviewing evidences about the relationship between gender and economic consumption in health, based on worldwide scientific literature published in the last 5 years...
May 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28486917/long-lasting-insulin-treatment-via-a-single-subcutaneous-administration-of-liposomes-in-thermoreversible-pluronic%C3%A2-f127-based-hydrogel
#13
Xiaoyu Chen, Blenda Chi Kwan Wong, Hubiao Chen, Shiping Zhang, Zhaoxiang Bian, Ge Zhang, Congcong Lin, Muhammad Kashif Riaz, Deependra Tyagi, Aiping Lu, Zhijun Yang
BACKGROUND: Repeated administrations of insulin injection on daily basis accompany pain and arise numerous complications with adverse effects on the diabetic patients life quality. Moreover, wearing insulin pump is also associated with several problems of diabetic ketoacidosis, catheter site infection, contact dermatitis and high cost. METHODS: We have developed an in situ gel system, consisting of insulin-loaded liposomes dispersed within a thermoreversible gel (Pluronic® F127 gel), which increases the duration of insulin action for the treatment of diabetes...
May 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28486916/are-markers-of-cardiac-dysfunction-useful-in-the-assessment-of-cardiovascular-risk-in-dialysis-patients
#14
Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Maciej Banach, Jacek Rysz
Cardiovascular morbidity and mortality of dialysis patients is a major problem in this group. The purpose of this study was also to evaluate whether any of studied markers are better than troponin in early detection of the occurrence of ventricular arrhythmias and prolongation of QT interval. This study included 45 patients undergoing haemodialysis. ECG Holter and echocardiographic examination were performed before and after dialysis. The concentration of markers: copeptin, GDF-15, HFABP and troponin were measured with the use of ELISA tests...
May 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28486915/3d-in-vitro-models-of-early-pregnancy-how-to-choose-the-right-scaffolding-material
#15
Damián Muzzio, María Lucía Foglia, Martin Federico Desimone, Marek Zygmunt
Following fertilization, the blastocyst has to complete two distinct steps to assure further development of pregnancy. After apposition it establishes a firm connection with the luminal epithelium of the endometrium (attachment) and subsequently enters the decidualizing stroma (invasion). If this step is not achieved successfully, fertility problems arise. Development of the placenta ensures an adequate supply of nutrients and gas between the mother and the fetus. Preeclampsia is a prevalent disorder arising from defects in the process of placentation...
May 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28482782/anti-cancer-drug-delivery-using-carbohydrate-based-polymers
#16
Javad Ranjbari, Ahad Mokhtarzadeh, Abbas Alibakhshi, Maryam Tabarzad, Maryam Hejazi, Mohammad Ramezani
Polymeric drug delivery systems in the form of nanocarriers are the most interesting vehicles in anti-cancer therapy. Among different types of biocompatible polymers, carbohydrate-based polymers or polysaccharides are the most common natural polymers with complex structures consisting of long chains of monosaccharide or disaccharide units bound by glycosidic linkages. Their appealing properties such as availability, biocompatibility, biodegradability, low toxicity, high chemical reactivity, facile chemical modification and low cost led to their extensive applications in biomedical and pharmaceutical fields including development of nano-vehicles for delivery of anti-cancer therapeutic agents...
May 5, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28472916/the-chemo-biological-outreach-of-nano-biomaterials-implications-for-tissue-engineering-and-regenerative-medicine
#17
Pradeep Kumar, Yahya E Choonara, Riaz A Khan, Viness Pillay
Nanobiomaterials can be defined as materials interacting with and influencing the biological microenvironment at a nanointerface. Recently the basic as well as applied research related to nanobiomaterials - a conjugation of nano-, material- and life-sciences - has immensely evolved for therapeutics and related biotechnology areas. The current overview focused on the potential of nanobiomaterial-based substrates towards the generation of biocompatible surfaces, tissue engineering architectures, and regenerative medicine...
May 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28472915/nanotechnology-a-promising-tool-towards-wound-healing
#18
Thaís Alberti, Daniela S Coelho, Ana Voytena, Heloísa Pitz, Manuel de Prá, Letícia Mazzarino, Shirley Kuhnen, Rosa Maria Ribeiro-do-Valle, Marcelo Maraschin, Beatriz Veleirinho
Nanotechnology is an exciting emerging field with multiple applications in skin regeneration. Nanofibers have gained special attention in skin regeneration based on their structural similarity to the extracellular matrix. A wide variety of polymeric nanofibers with distinct properties have been developed and tested as scaffolds for skin regeneration. Besides providing support for tissue repair, nanofibrous materials can act as delivery systems for drugs, proteins, growth factors, and other molecules. Moreover, the morphology, biodegradability, and other functionalities of nanofibrous materials can be controlled towards specific conditions of wound healing...
May 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28472914/low-testosterone-levels-and-metabolic-syndrome-in-aging-male
#19
Rodrigo Blaya, Patrícia Blaya, Luiza Rhoden, Ernani Luis Rhoden
Advances in medicine and progressive improvements in the health of the general population in developed countries have led to considerable increases in life expectancy over recent years. Metabolic syndrome (MetS) affects approximately 25% of the adult population and its prevalence is increasing all over the world. Central obesity plays an important role in emergence of MetS. Some studies have suggested that there may be link between low Total Testosterone levels and emergence of MetS. The objective of this review is to analyze the complex network of interactions between MetS and low testosterone levels in elderly men, considering etiologic, diagnostic, and therapeutic aspects...
May 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28472913/fertility-and-sperm-quality-in-the-aging-male
#20
Susana Almeida, Luís Rato, Mário Sousa, Marco G Alves, Pedro F Oliveira
Parenthood at an older age is becoming a trend among men, especially in the most developed societies. Aging has a significant impact on male fertility. Older men exhibit notable disturbances in the reproductive axis, with steroidogenesis being impacted much more than spermatogenesis. The endocrine changes, together with morphological and functional alternations of the aging testis, result in decreased testosterone production. Nonetheless, studies are needed to scrutinize the impact of age per se versus age-induced dysfunction of the reproductive axis...
May 3, 2017: Current Pharmaceutical Design
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