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Current Pharmaceutical Design

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https://www.readbyqxmd.com/read/27774907/percutaneous-treatment-of-aortic-valve-disease-contemporary-overview-and-future-trends
#1
Marko Banovic, Jozef Bartunek, Serge D. Nikolic, Vladan Vukcevic, Srdjan Aleksandric, Bernard Iung
Efforts to develop and refine percutaneous approaches to cardiac valve repair and replacement have advanced rapidly over the past several years, having exceeded even the most optimistic expectations. New innovations have been predominantly directed toward the most frequent form of valvular heart disease (VHD) in the industrialized world; aortic stenosis (AS). Approximately 250,000 transcatheter aortic valve implantation (TAVI) procedures have been done so far addressing this significant medical need. Because of the predominance of degenerative etiologies, the prevalence of VHD increases markedly in population above the age of 65 years, in particular with regard to severe AS...
April 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28425865/editorial-hiv-and-antiretroviral-drugs-current-status-and-new-challenges
#2
EDITORIAL
Georgios Nikolopoulos, Stefanos Bonovas
No abstract text is available yet for this article.
April 19, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28425864/editorial-phytochemicals-and-their-effects-on-human-health
#3
EDITORIAL
Lillian Barros, Isabel C F R Ferreira
No abstract text is available yet for this article.
April 19, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28425863/targeted-drug-delivery-based-on-gold-nanoparticle-derivatives
#4
Mazaher Gholipourmalekabadi, Mohammadmahdi Mobaraki, Maryam Ghaffari, Amir Zarebkohan, Vahid F Omrani, Aleksandra M Urbanska, Alexander Seifalian
Drug delivery systems are effective and attractive methods which allow therapeutic substances to be introduced into the body more effectively and safe by having tunable delivery rate and release target site. Gold nanoparticles (AuNPs) have a myriad of favorable physical, chemical, optical, thermal and biological properties that make them highly suitable candidates as non-toxic carriers for drug and gene delivery. The surface modifications of AuNPs profoundly improve their circulation, minimize aggregation rates, enhance attachment to therapeutic molecules and target agents due to their nano range size which further increases their ability to cross cell membranes and reduce overall cytotoxicity...
April 19, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28413972/xanthine-oxidase-and-its-role-as-target-in-cardiovascular-disease-cardiovascular-protection-by-enzyme-inhibition
#5
Mirjam Schuchardt, Jaqueline Herrmann, Markus Tölle, Markus van der Giet
BACKGROUND: Formerly, hyperuricemia was mainly restricted to the rich population, but now-a-days it is a condition affecting wide parts of western civilization. Although only a minority of our population develops clinically relevant symptomatic hyperuricemia, there is growing evidence that elevated serum uric acid levels might be associated with elevated cardiovascular risk and cardiovascular disease progression. But it is not clear whether uric acid is just a biomarker or exerts detrimental effects itself...
April 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28412905/therapeutic-potential-of-heme-oxygenase-1-carbon-monoxide-system-against-ischemia-reperfusion-injury
#6
Yuanyuan Cheng, Jianhui Rong
BACKGROUND: Ischemia-reperfusion (I/R) injury causes the dysfunctions of different major organs, leading to morbidity and mortality on the global scale. Among a battery of therapeutic targets, the heme oxygenase-1 (HO-1)/carbon monoxide (CO) system has been evaluated for the development of new therapies against I/R injury. The enzyme HO-1 catalyzes the degradation of heme into three biologically active end products, namely biliverdin/bilirubin, CO and ferrous ion. Interestingly, CO is one of a few bioactive gaseous molecules with the capability of regulating inflammation, cell survival and growth...
April 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28412904/the-role-of-exosomes-and-exosome-derived-micrornas-in-atherosclerosis
#7
Xinjie Lu
BACKGROUND: Atherosclerosis is the leading cause of death and morbidity throughout industrialized nations, accounting for one-fifth of all deaths globally. Exosomes are bi-lipid membranous vesicles containing protein, lipid and nucleic acid contents that are released from cells via the endolysosomal pathway. Exosomes are derived from several cells including macrophages, dendritic cells, platelets as well as human serum. METHODS: In this review, an overview of recent advances and the evidence for the role exosomes and exosome-derived microRNAs (miRNAs) in atherosclerosis are provided...
April 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28403584/editorial-new-avenues-and-therapeutic-strategies-for-the-treatment-of-neurodegenerative-diseases
#8
Ana Raquel Esteves
No abstract text is available yet for this article.
April 13, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28403793/more-than-just-size-challenges-and-opportunities-of-hybrid-dendritic-nanocarriers
#9
Guido Noé Rimondino, Gabriela Oksdath-Mansilla, Verónica Brunetti, Miriam Cristina Strumia
BACKGROUND: Dendrimers and hyperbranched polymers are emerging polymer architectures that attract increasing attention due to their unique topological structure and interesting physicochemical properties. Their enormous potential makes them particularly attractive to form new and fascinating nanometric drug delivery systems, solving several typical shortcomings encountered in nanomedicine. OBJECTIVE: In this context, the recent developments of dendritic and hyperbranched based systems, together with their application as nanocarriers, have been comprehensively reviewed...
April 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28403792/nanocarriers-in-improving-chemotherapy-of-multidrug-resistant-tumors-key-developments-and-perspective
#10
Dimitry A Chistiakov, Veronika A Myasoedova, Alexander N Orekhov, Yuri V Bobryshev
The multidrug resistance (MDR) of tumor cells significantly reduces the efficiency of traditional anticancer therapy. Tumor MDR is complex and involves several mechanisms such as decreased drug uptake, increased drug efflux, enhanced drug exocytosis, increased drug detoxification and inactivation by drug-metabolizing enzymes, altered drug targets due to genetic and epigenetic modifications, altered DNA repair, and impaired apoptotic pathways. Implementation of nanoparticles can markedly improve drug delivery through increased stability in the plasma, prolonged half-life, enhanced specificity of transfer, and advanced drug accumulation and retention in the tumor cells...
April 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28403791/multimeric-system-of-rgd-grafted-pmma-nanoparticles-as-a-targeted-drug-delivery-system-for-paclitaxel
#11
Gibbens-Bandala Brenda Vianey, Ocampo-García Blanca Eli, Ferro-Flores Guillermina, Morales-Avila Enrique, Ancira-Cortez Alejandra, Jaimes-Aguirre Laura
BACKGROUND: Polymer-based nanoparticles as drug-delivery systems offer new therapeutic opportunities. Among them, ligand-mediated targeting, which increases selectivity and efficacy, allows controllable drug delivery. The aim of the this research was to prepare and characterize poly(methyl methacrylate) (PMMA) nanoparticles grafted with the -Arginine, Glycine, Aspartic Acid (RGD)- peptide sequence as a promising smart drug delivery system for Paclitaxel (PTX), directed at the sites of integrin receptor overexpression...
April 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28393699/approaches-of-the-transcriptomic-analysis-in-astrocytes-potential-pharmacological-targets
#12
George E Barreto, Rosa M Gómez, Rosa Helena Bustos, Diego A Forero, Gjumrakch Aliev, Jerzy Leszek, Valentina Echeverria, Janneth Gonzalez
Astrocytes are important glial cells involved in the ionic regulation of the extracellular fluid in the Central Nervous System (CNS), the formation of the blood brain barrier (BBB) and the support to neurons for the maintaining of the Krebs cycle intermediaries. Even though these cells are known to be important for the brain functioning, several of their functions and their development have not been fully elucidated. In this context, identifying the algorithms used for their analysis plays a pivotal role in the development of new strategies in the study of astrocytes...
April 6, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356044/an-updated-portrait-of-pathogenesis-molecular-markers-and-signaling-pathways-of-hepatocellular-carcinoma
#13
Muthukumaran Jayachandran
Hepatocellular carcinoma (HCC) is the vital cause of cancer -related death throughout the world. At present, the exact mechanism responsible for the formation of HCC and its maintenance remains suspicious. Hepatocarcinogenesis involves a multistep activity involving several genetic aberrations which result in malignant transformation of the liver cells. The prevalence and occurrence of this disease are kept on increasing and an increase in the liver transplantation cases are vital indications for it. In the past decades, significant progress has been achieved toward the better elucidation of molecular pathways of oncogenic processes...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356043/pre-exposure-prophylaxis-for-hiv-evidence-and-perspectives
#14
Georgios K Nikolopoulos, Eirini Christaki, Dimitrios Paraskevis, Stefanos Bonovas
HIV remains an important public health issue worldwide. However, new prevention approaches have recently been developed and are very promising. Antiretroviral treatment as prevention, or as a prophylaxis after exposure to HIV, has been shown to reduce the likelihood of HIV acquisition. Over the last years, animal studies and randomized clinical trials in humans showed that antiretrovirals can also be efficacious and safe if used once daily, or intermittently, as prophylaxis before an individual is exposed to HIV (Pre-exposure Prophylaxis - PrEP)...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356042/recent-advances-in-oncological-submissions-of-dendrimer
#15
Namrata Soni, Muktika Tekade, Prashant Kesharwani, Pallab Bhattacharya, Rahul Maheshwari, Kamal Dua, Philp M Hansbro, Rakesh Kumar Tekade
BACKGROUND: Disseminated metastatic cancer requires insistent management owing to its reduced responsiveness for chemotherapeutic agents, toxicity to normal cells consequently lower survival rate and hampered quality of life of patients. METHODS: Dendrimer mediated cancer therapy is advantageous over conventional chemotherapy, radiotherapy and surgical resection due to reduced systemic toxicity, and molecular level cell injury to cancerous mass, for an appreciable survival of the subject...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356041/recent-advances-in-antiretroviral-agents-potent-integrase-inhibitors
#16
Mina Psichogiou, Garyphalia Poulakou, Dimitrios Basoulis, Dimitrios Paraskevis, Antonios Markogiannakis, George L Daikos
Integrase strand transfer inhibitors (INSTIs) belong to a novel class of antiretroviral agents that have emerged as the new first-line treatments. Three such compounds are currently available, raltegravir, elvitegravir, dolutegravir and two more under development, bictegravir and cabotegravir. These compounds share the same mode of action but exhibit different pharmacokinetic/ pharmacodynamic properties, and drug-drug interactions. A series of studies in the past decade have established their efficacy compared to previous regimens, both in treatment-naïve and experienced patients...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356040/the-relevance-of-dietary-polyphenols-in-cardiovascular-protection
#17
Ana Gabriela Murillo, Maria Luz Fernandez
The chemical structure of polyphenols consisting of aromatic rings, capable of quenching free radicals, makes them ideal candidates to protect against oxidation. Polyphenols are present in a variety of foods including grapes, berries, dark chocolate, coffee and tea to mention a few. A number of studies have shown that dietary polyphenols exert a protective effect against hypertension, dyslipidemias, inflammation, endothelial function and atherosclerosis, conditions associated with increased risk for cardiovascular disease...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356039/the-potential-protective-effects-of-phenolic-compounds-against-low-density-lipoprotein-oxidation
#18
Ryszard Amarowicz, Ronald B Pegg
BACKGROUND: The exact mechanism(s) of atherosclerosis in humans remains elusive, but one theory hypothesizes that this deleterious process results from the oxidative modification of low-density lipoprotein (LDL). Research suggests that foods rich in dietary phenolic compounds with antioxidant activity can mitigate the extent of LDL oxidation in vivo. With regard to the different classes of flavonoids, there appears to be a structure-function relationship between the various moieties/constituents attached to the flavonoids' three ring system and their impact at retarding LDL oxidation...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356038/factors-associated-with-hiv-testing-and-hiv-treatment-adherence-a-systematic-review
#19
Marios Detsis, Constantinos Tsioutis, Spyridon A Karageorgos, Theologia Sideroglou, Angelos Hatzakis, Eleftherios Mylonakis
BACKGROUND: The impact of the global economic crisis on HIV-related access and care remains unclear. The objective of this systematic review of the literature was to evaluate the association between socioeconomic factors and HIV diagnosis, and adherence to treatment, following the 2008 global economic crisis. METHODS: A systematic search of PubMed and Scopus for studies published between January 2008 and October 2016 was conducted. Studies providing data on social, demographic, economic and cultural barriers associated with HIV diagnosis and treatment were included...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356037/markers-of-early-vascular-ageing
#20
Vasilios Kotsis, Christina Antza, Ioannis Doundoulakis, Stella Stabouli
BACKGROUND: Cardiovascular damage is clinically manifested as coronary artery disease, heart failure, stroke and peripheral artery disease. The prevalence of these adverse conditions is higher with advancing age. Although many patients present cardiovascular damage late in their life, it is common to see patients with early atherosclerosis in cardiovascular intensive care units at ages lower than 50 years in men and 55 for women. METHODS AND RESULTS: In this review of the literature we identified risk factors of early vascular damage...
March 28, 2017: Current Pharmaceutical Design
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