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Journal of Mammary Gland Biology and Neoplasia

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https://www.readbyqxmd.com/read/27900586/role-of-prolactin-in-promotion-of-immune-cell-migration-into-the-mammary-gland
#1
Riva Dill, Ameae M Walker
Immune cells in the mammary gland play a number of important roles, including protection against infection during lactation and, after passing into milk, modulation of offspring immunity. However, little is known about the mechanism of recruitment of immune cells to the lactating gland in the absence of infection. Given the importance of prolactin to other aspects of lactation, we hypothesized it would also play a role in immune cell recruitment. Prolactin treatment of adult female mice for a period equivalent to pregnancy and the first week of lactation increased immune cell flux through the mammary gland, as reflected in the number of immune cells in mammary gland-draining, but not other lymph nodes...
November 29, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27889858/the-pursuit-of-truth-in-the-company-of-friends-in-memorium-charles-w-daniel
#2
EDITORIAL
Gary B Silberstein, Michael T Lewis
No abstract text is available yet for this article.
November 26, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27889857/accurate-control-of-17%C3%AE-estradiol-long-term-release-increases-reliability-and-reproducibility-of-preclinical-animal-studies
#3
Céline Gérard, Anne Gallez, Charline Dubois, Pierre Drion, Philippe Delahaut, Etienne Quertemont, Agnès Noël, Christel Pequeux
Estrogens are the subject of intensive researches aiming to elucidate their mechanism of action on the various tissues they target and especially on mammary gland and breast cancer. The use of ready-to-use slow releasing devices to administer steroids, especially estrogens, to small experimental animals remains the method of choice in terms of animal well-being and of safety for both the researcher and the animal. In this study, we evaluated and compared, in vitro and in vivo, the release kinetic of estradiol (E2) over sixty days from two different slow-releasing systems: the matrix pellet (MP) and the reservoir implant (RI)...
November 26, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27815674/epithelial-plasticity-during-human-breast-morphogenesis-and-cancer-progression
#4
REVIEW
Saevar Ingthorsson, Eirikur Briem, Jon Thor Bergthorsson, Thorarinn Gudjonsson
Understanding the complex events leading to formation of an epithelial-based organ such as the breast requires a detailed insight into the crosstalk between epithelial and stromal compartments. These interactions occur both through heterotypic cellular interactions and between cells and matrix components. While in vivo models may partially capture these complex interactions, there is a need for in- vitro models to study these events. In this review we discuss cell-cell interactions in breast development focusing on the stem cell niche and branching morphogenesis...
November 4, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27815673/erratum-to-patient-derived-mammosphere-and-xenograft-tumour-initiation-correlates-with-progression-to-metastasis
#5
Rachel Eyre, Denis G Alférez, Kath Spence, Mohamed Kamal, Frances L Shaw, Bruno M Simões, Angélica Santiago-Gómez, Aida Sarmiento-Castro, Maria Bramley, Mohammed Absar, Zahida Saad, Sumohan Chatterjee, Cliona Kirwan, Ashu Gandhi, Anne C Armstrong, Andrew M Wardley, Ciara S O'Brien, Gillian Farnie, Sacha J Howell, Robert B Clarke
No abstract text is available yet for this article.
November 4, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27796616/human-milk-fatty-acid-composition-comparison-of-novel-dried-milk-spot-versus-standard-liquid-extraction-methods
#6
Michael C Rudolph, Bridget E Young, Kristina Harris Jackson, Nancy F Krebs, William S Harris, Paul S MacLean
Accurate assessment of the long chain polyunsaturated fatty acid (LC-PUFA) content of human milk (HM) provides a powerful means to evaluate the FA nutrient status of breastfed infants. The conventional standard for FA composition analysis of HM is liquid extraction, trans-methylation, and analyte detection resolved by gas chromatography. This standard approach requires fresh or frozen samples, storage in deep freeze, organic solvents, and specialized equipment in processing and analysis. Further, HM collection is often impractical for many studies in the free living environment, particularly for studies in developing countries...
October 28, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27744517/the-many-axes-of-deer-lactation
#7
Francisco Ceacero, Andrés J García, Tomás Landete-Castillejos, Martina Komárková, Francisco Hidalgo, Martina P Serrano, Laureano Gallego
In undomesticated animals information about the production and composition of milk over time is still scarce. In general, for most mammals it is known that milk composition changes across lactation, is different for male and female offspring, and even that marsupials, such as kangaroos, can simultaneously produce milk of different compositions for young of different ages. Such parallel milk production of differing compositions has not yet been studied in single-offspring placental mammals, but may help to explain behavioural processes like allosuckling (feeding the young of other adults) and lateralized suckling preferences...
October 15, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27714576/comparison-of-the-adipose-and-luminal-mammary-gland-compartment-as-orthotopic-inoculation-sites-in-a-4t1-based-immunocompetent-preclinical-model-for-triple-negative-breast-cancer
#8
Jonas Steenbrugge, Koen Breyne, Sofie Denies, Melissa Dekimpe, Kristel Demeyere, Olivier De Wever, Peter Vermeulen, Steven Van Laere, Niek N Sanders, Evelyne Meyer
Breast tumorigenesis is classically studied in mice by inoculating tumor cells in the fat pad, the adipose compartment of the mammary gland. Alternatively, the mammary ducts, which constitute the luminal mammary gland compartment, also provide a suitable inoculation site to induce breast cancer in murine models. The microenvironments in these compartments influence tumor cell progression, yet this effect has not been investigated in an immunocompetent context. Here, we compared both mammary gland compartments as distinct inoculation sites, taking into account the immunological aspect by inoculating 4T1 tumor cells in immunocompetent mice...
October 6, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27680982/patient-derived-mammosphere-and-xenograft-tumour-initiation-correlates-with-progression-to-metastasis
#9
Rachel Eyre, Denis G Alférez, Kath Spence, Mohamed Kamal, Frances L Shaw, Bruno M Simões, Angélica Santiago-Gómez, Aida Sarmiento-Castro, Maria Bramley, Mohammed Absar, Zahida Saad, Sumohan Chatterjee, Cliona Kirwan, Ashu Gandhi, Anne C Armstrong, Andrew M Wardley, Ciara S O'Brien, Gillian Farnie, Sacha J Howell, Robert B Clarke
Breast cancer specific mortality results from tumour cell dissemination and metastatic colonisation. Identification of the cells and processes responsible for metastasis will enable better prevention and control of metastatic disease, thus reducing relapse and mortality. To better understand these processes, we prospectively collected 307 patient-derived breast cancer samples (n = 195 early breast cancers (EBC) and n = 112 metastatic samples (MBC)). We assessed colony-forming activity in vitro by growing isolated cells in both primary (formation) and secondary (self-renewal) mammosphere culture, and tumour initiating activity in vivo through subcutaneous transplantation of fragments or cells into mice...
September 28, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27544761/retraction-note-to-roles-of-micrornas-and-other-non-coding-rnas-in-breast-cancer-metastasis
#10
Scott Valastyan
No abstract text is available yet for this article.
August 20, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27518775/generation-of-multicellular-breast-cancer-tumor-spheroids-comparison-of-different-protocols
#11
Karolin Froehlich, Jan-Dirk Haeger, Julia Heger, Jana Pastuschek, Stella Mary Photini, Yan Yan, Amelie Lupp, Christiane Pfarrer, Ralf Mrowka, Ekkehard Schleußner, Udo R Markert, André Schmidt
Multicellular tumor spheroids are widely used models in tumor research. Because of their three dimensional organization they can simulate avascular tumor areas comprising proliferative and necrotic cells. Nonetheless, protocols for spheroid generation are still inconsistent. Therefore, in this study the breast cancer cell lines MCF-7, MDA-MB-231 and SK-BR-3 have been used to compare different spheroid generation models including hanging drop, liquid overlay and suspension culture techniques, each under several conditions...
August 12, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27411687/p120-catenin-is-critical-for-the-development-of-invasive-lobular-carcinoma-in-mice
#12
Milou Tenhagen, Sjoerd Klarenbeek, Tanya M Braumuller, Ilse Hofmann, Petra van der Groep, Natalie Ter Hoeve, Elsken van der Wall, Jos Jonkers, Patrick W B Derksen
Loss of E-cadherin expression is causal to the development of invasive lobular breast carcinoma (ILC). E-cadherin loss leads to dismantling of the adherens junction and subsequent translocation of p120-catenin (p120) to the cytosol and nucleus. Although p120 is critical for the metastatic potential of ILC through the regulation of Rock-dependent anoikis resistance, it remains unknown whether p120 also contributes to ILC development. Using genetically engineered mouse models with mammary gland-specific inactivation of E-cadherin, p120 and p53, we demonstrate that ILC formation induced by E-cadherin and p53 loss is severely impaired upon concomitant inactivation of p120...
July 13, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27314856/erratum-to-exome-sequencing-of-slc30a2-identifies-novel-loss-and-gain-of-function-variants-associated-with-breast-cell-dysfunction
#13
Samina Alam, Stephen R Hennigar, Carla Gallagher, David I Soybel, Shannon L Kelleher
No abstract text is available yet for this article.
June 17, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27255141/binuclear-cells-in-the-lactating-mammary-gland-new-insights-on-an-old-concept
#14
REVIEW
Gilbert H Smith
In a recent paper (Rios et al. Nat Commun. 7:11400, 2016), it was reported that polyploid cells are frequent in lactating mammary tissues. This phenomenon was observed in mammary tissue sampled from five separate mammalian species. According to that report, these binucleated cells occur late in pregnancy and early in lactation. Unfortunately, this paper did not mention a number of earlier observations and findings that remain pertinent to this day (Banerjee et al. Life sciences Pt 2: Biochemistry, general and molecular biology...
June 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27236659/in-memoriam-isabel-a-forsyth-1936-2016
#15
EDITORIAL
Margaret C Neville, Malcolm Peaker
No abstract text is available yet for this article.
June 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27194029/interstitial-fluid-sphingosine-1-phosphate-in-murine-mammary-gland-and-cancer-and-human-breast-tissue-and-cancer-determined-by-novel-methods
#16
Masayuki Nagahashi, Akimitsu Yamada, Hiroshi Miyazaki, Jeremy C Allegood, Junko Tsuchida, Tomoyoshi Aoyagi, Wei-Ching Huang, Krista P Terracina, Barbara J Adams, Omar M Rashid, Sheldon Milstien, Toshifumi Wakai, Sarah Spiegel, Kazuaki Takabe
The tumor microenvironment is a determining factor for cancer biology and progression. Sphingosine-1-phosphate (S1P), produced by sphingosine kinases (SphKs), is a bioactive lipid mediator that regulates processes important for cancer progression. Despite its critical roles, the levels of S1P in interstitial fluid (IF), an important component of the tumor microenvironment, have never previously been measured due to a lack of efficient methods for collecting and quantifying IF. The purpose of this study is to clarify the levels of S1P in the IF from murine mammary glands and its tumors utilizing our novel methods...
June 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27059487/adipokines-and-vascular-endothelial-growth-factor-in-normal-human-breast-tissue-in-vivo-correlations-and-attenuation-by-dietary-flaxseed
#17
Vivian Morad, Annelie Abrahamsson, Preben Kjölhede, Charlotta Dabrosin
Exposure to sex steroids increases the risk of breast cancer but the exact mechanisms are yet to be elucidated. Events in the microenvironment are important for carcinogenesis. Diet containing phytoestrogens can affect the breast microenvironment and alter the risk of breast cancer. It has previously been shown that estrogen regulates extracellular levels of leptin, adiponectin, and VEGF in normal breast tissue in vivo. Whether these proteins correlate in breast tissue in vivo or if diet addition of flaxseed, a major source of phytoestrogens in Western diets, alters adipokine levels in breast tissue are unknown...
June 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27048289/isolation-of-endoplasmic-reticulum-fractions-from-mammary-epithelial-tissue
#18
Eric Chanat, Annabelle Le Parc, Hichem Lahouassa, Bouabid Badaoui
In the mammary glands of lactating animals, the mammary epithelial cells that surround the lumen of the acini produce and secrete copious amounts of milk. Functional differentiation of these mammary epithelial cells depends on the development of high-efficiency secretory pathways, notably for protein and lipid secretion. Protein secretion is a fundamental process common to all animal cells that involves a subset of cellular organelles, including the endoplasmic reticulum and the Golgi apparatus. In contrast, en masse secretion of triglycerides and cholesterol esters in the form of milk fat globules is a unique feature of the mammary epithelial cell...
June 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27002722/a-comparative-study-on-the-in-vitro-effects-of-the-dna-methyltransferase-inhibitor-5-azacytidine-5-azac-in-breast-mammary-cancer-of-different-mammalian-species
#19
REVIEW
Rebecca M Harman, Theresa M Curtis, David J Argyle, Scott A Coonrod, Gerlinde R Van de Walle
Murine models are indispensible for the study of human breast cancer, but they have limitations: tumors arising spontaneously in humans must be induced in mice, and long-term follow up is limited by the short life span of rodents. In contrast, dogs and cats develop mammary tumors spontaneously and are relatively long-lived. This study examines the effects of the DNA methyltransferase (DNMT) inhibitor 5-Azacytidine (5-AzaC) on normal and tumoral mammary cell lines derived from dogs, cats and humans, as proof of concept that small companion animals are useful models of human breast cancer...
June 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/26769216/a-molecular-view-of-pathological-microcalcification-in-breast-cancer
#20
REVIEW
Tanu Sharma, James A Radosevich, Geeta Pachori, Chandi C Mandal
Breast microcalcification is a potential diagnostic indicator for non-palpable breast cancers. Microcalcification type I (calcium oxalate) is restricted to benign tissue, whereas type II (calcium hydroxyapatite) occurs both in benign as well as in malignant lesions. Microcalcification is a pathological complication of the mammary gland. Over the past few decades, much attention has been paid to exploit this property, which forms the basis for advances in diagnostic procedures and imaging techniques. The mechanism of its formation is still poorly understood...
June 2016: Journal of Mammary Gland Biology and Neoplasia
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