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Journal of Mammary Gland Biology and Neoplasia

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https://www.readbyqxmd.com/read/29968174/polarized-secretion-of-extracellular-vesicles-by-mammary-epithelia
#1
Andrew R Chin, Wei Yan, Minghui Cao, Xuxiang Liu, Shizhen Emily Wang
Extracellular vesicles (EVs) are secreted by many cell types and are increasingly investigated for their role in human diseases including cancer. Here we focus on the secretion and potential physiological function of non-pathological EVs secreted by polarized normal mammary epithelial cells. Using a transwell system to allow formation of epithelial polarity and EV collection from the apical versus basolateral compartments, we found that impaired secretion of EVs by knockdown of RAB27A or RAB27B suppressed the establishment of mammary epithelial polarity, and that addition of apical but not basolateral EVs suppressed epithelial polarity in a dose-dependent manner...
July 3, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29956080/histology-and-transcriptome-profiles-of-the-mammary-gland-across-critical-windows-of-development-in-sprague-dawley-rats
#2
Kalpana Gopalakrishnan, Susan L Teitelbaum, James Wetmur, Fabiana Manservisi, Laura Falcioni, Simona Panzacchi, Federica Gnudi, Fiorella Belpoggi, Jia Chen
Breast development occurs through well-defined stages representing 'windows of susceptibility' to adverse environmental exposures that potentially modify breast cancer risk. Systematic characterization of morphology and transcriptome during normal breast development lays the foundation of our understanding of cancer etiology. We examined mammary glands in female Sprague Dawley rats across six developmental stages - pre-pubertal, peri-pubertal, pubertal, lactation, adult parous and adult nulliparous. We investigated histology by Hematoxylin and Eosin and Mallory's Trichrome stain, proliferative and apoptotic rate by immunohistochemistry and whole-transcriptome by microarrays...
June 28, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29948751/oxytocin-induces-mammary-epithelium-disruption-and-could-stimulate-epithelial-cell-exfoliation
#3
L Herve, V Lollivier, H Quesnel, Marion Boutinaud
Mammary epithelial cells (MEC) are exfoliated from the epithelium into milk, influencing the number of MEC present in the udder. This process is associated with epithelium integrity. The release of oxytocin (OT) induced by milking causes myoepithelial cell contraction, which, in turn, may stimulate MEC exfoliation through mechanical forces. To investigate the role of OT in MEC exfoliation, we inhibited or induced myoepithelial cell contraction by injecting the OT receptor antagonist atosiban (Ato) or a supraphysiological dose of OT, respectively...
June 8, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29876871/ciap2-is-an-independent-signaling-and-survival-factor-during-mammary-lactational-involution-and-tumorigenesis
#4
David Carr, Rosanna Lau, Alexandra D Hnatykiw, Gwendoline C D Ward, Manijeh Daneshmand, Miguel A Cabrita, M A Christine Pratt
Cellular inhibitor of apoptosis proteins-1 and -2 (cIAP1/2) are integral to regulation of apoptosis and signaling by the tumor necrosis factor (TNF) and related family of receptors. The expression of cIAP2 in tissues is typically low and considered functionally redundant with cIAP1, however cIAP2 can be activated by a variety of cellular stresses. Members of the TNFR family and their ligands have essential roles in mammary gland biology. We have found that cIAP2-/- virgin mammary glands have reduced ductal branching and delayed lobuloalveogenesis in early pregnancy...
June 6, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29855766/attenuation-of-mammary-gland-dysplasia-and-feeding-difficulties-in-tabby-mice-by-fetal-therapy
#5
Mandy Wahlbuhl, Sonia Schuepbach-Mallepell, Christine Kowalczyk-Quintas, Angela Dick, Fabian B Fahlbusch, Pascal Schneider, Holm Schneider
Hypohidrotic ectodermal dysplasias (HED) are hereditary differentiation disorders of multiple ectodermal structures including the mammary gland. The X-linked form of HED (XLHED) is caused by a lack of the secreted signaling molecule ectodysplasin A1 (EDA1) which is encoded by the gene EDA and belongs to the tumor necrosis factor (TNF) superfamily. Although male patients (hemizygous) are usually more severely affected by XLHED, heterozygous female carriers of an EDA mutation may also suffer from a variety of symptoms, in particular from abnormal development of their breasts...
June 1, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29777406/can-bovine-leukemia-virus-be-related-to-human-breast-cancer-a-review-of-the-evidence
#6
REVIEW
Lucia Martinez Cuesta, Pamela Anahi Lendez, Maria Victoria Nieto Farias, Guillermina Laura Dolcini, Maria Carolina Ceriani
The incidence of breast cancer is continuously increasing worldwide, as influenced by many factors that act synergistically. In the last decade there was an increasing interest in the possible viral etiology of human breast cancer. Since then, many viruses have been associated with this disease (murine mammary tumor virus, MMTV; Epstein-Barr virus, EBV; and human papillomavirus, HPV). Recently, BLV has been identified in human breast cancers giving rise to the hypothesis that it could be one of the causative agents of this condition...
May 18, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29744755/radiological-histological-and-chemical-analysis-of-breast-microcalcifications-diagnostic-value-and-biological-significance
#7
Rita Bonfiglio, Manuel Scimeca, Nicola Toschi, Chiara Adriana Pistolese, Elena Giannini, Chiara Antonacci, Sara Ciuffa, Virginia Tancredi, Umberto Tarantino, Loredana Albonici, Elena Bonanno
Classification of mammary microcalcifications is based on radiological and histological characteristics that are routinely evaluated during the diagnostic path for the identification of breast cancer, or in patients at risk of developing breast cancer. The main aim of this study was to explore the relationship between the imaging parameters most commonly used for the study of mammary microcalcifications and the corresponding histological and chemical properties. To this end, we matched the radiographic characteristics of microcalcifications to breast lesion type, histology of microcalcifications and elemental composition of microcalcifications as obtained by energy dispersive x ray (EDX)-microanalysis...
May 9, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29705830/the-mammary-microenvironment-in-mastitis-in-humans-dairy-ruminants-rabbits-and-rodents-a-one-health-focus
#8
REVIEW
Katherine Hughes, Christine J Watson
The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One Health approach. In this review, we will evaluate the role of the mammary microenvironment in mastitis in humans, ruminants and rabbits, where appropriate also drawing on studies utilising laboratory animal models...
June 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29687293/psychosocial-stress-exposure-disrupts-mammary-gland-development
#9
Marianna B Johnson, Joscelyn N Hoffmann, Hannah M You, Ricardo R Lastra, Sully Fernandez, Jordan W Strober, Ahmad B Allaw, Matthew J Brady, Suzanne D Conzen, Martha K McClintock
Exposure to psychosocial stressors and ensuing stress physiology have been associated with spontaneous invasive mammary tumors in the Sprague-Dawley rat model of human breast cancer. Mammary gland (MG) development is a time when physiologic and environmental exposures influence breast cancer risk. However, the effect of psychosocial stress exposure on MG development remains unknown. Here, in the first comprehensive longitudinal study of MG development in nulliparous female rats (from puberty through young adulthood; 8-25 wks of age), we quantify the spatial gradient of differentiation within the MG of socially stressed (isolated) and control (grouped) rats...
June 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29644495/does-the-mouse-mammary-gland-arise-from-unipotent-or-multipotent-mammary-stem-progenitor-cells
#10
REVIEW
Gilbert H Smith, Daniel Medina
The presence of long-lived lineage restricted progenitor and multipotent progenitor cells in adult mouse mammary gland for cancer development is compelling. Mammary cancers are phenotypically diverse This might be explained by transformation of long-lived, lineage-limited progenitor subpopulations. Mammary multipotent epithelial stem cells and their environmental niches must be considered, since their niche(s), once empty might be occupied by lineage-limited progenitors that are proximal. The existence of premalignant mammary populationst that manifest characteristics of lineage limitation argues strongly for this proposition...
June 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29633073/moderate-high-temperature-condition-induces-the-lactation-capacity-of-mammary-epithelial-cells-through-control-of-stat3-and-stat5-signaling
#11
Ken Kobayashi, Yusaku Tsugami, Kota Matsunaga, Takahiro Suzuki, Takahiro Nishimura
In lactating mammary glands, alveolar mammary epithelial cells (MECs) synthesize and secrete milk components. MECs also form less permeable tight junctions (TJs) to prevent the leakage of milk components. During lactation, MECs are exposed to temperature changes by metabolic heat production and air ambient temperature. In this study, we investigated whether temperature changes influence milk production ability and TJ barriers in MECs by using two lactating culture models. The results showed that 39 °C treatment activated milk production and enhanced the formation of less-permeable TJs...
June 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29603039/could-use-of-selective-serotonin-reuptake-inhibitors-during-lactation-cause-persistent-effects-on-maternal-bone
#12
REVIEW
Samantha R Weaver, Laura L Hernandez
The lactating mammary gland elegantly coordinates maternal homeostasis to provide calcium for milk. During lactation, the monoamine serotonin regulates the synthesis and release of various mammary gland-derived factors, such as parathyroid hormone-related protein (PTHrP), to stimulate bone resorption. Recent evidence suggests that bone mineral lost during prolonged lactation is not fully recovered following weaning, possibly putting women at increased risk of fracture or osteoporosis. Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants have also been associated with reduced bone mineral density and increased fracture risk...
June 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29574638/long-chain-omega-3-polyunsaturated-fatty-acids-modulate-mammary-gland-composition-and-inflammation
#13
Saraswoti Khadge, Geoffrey M Thiele, John Graham Sharp, Timothy R McGuire, Lynell W Klassen, Paul N Black, Concetta C DiRusso, James E Talmadge
Studies in rodents have shown that dietary modifications as mammary glands (MG) develop, regulates susceptibility to mammary tumor initiation. However, the effects of dietary PUFA composition on MGs in adult life, remains poorly understood. This study investigated morphological alterations and inflammatory microenvironments in the MGs of adult mice fed isocaloric and isolipidic liquid diets with varying compositions of omega (ω)-6 and long-chain (Lc)-ω3FA that were pair-fed. Despite similar consumption levels of the diets, mice fed the ω-3 diet had significantly lower body-weight gains, and abdominal-fat and mammary fat pad (MFP) weights...
June 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29464498/milk-proteins-are-predigested-within-the-human-mammary-gland
#14
Søren D Nielsen, Robert L Beverly, David C Dallas
Previous work demonstrates that proteases present in human milk release hundreds of peptides derived from milk proteins. However, the question of whether human milk protein digestion begins within the mammary gland remains incompletely answered. The primary objective of this study was to determine whether proteolytic degradation of human milk proteins into peptides begins within the mammary gland. The secondary objectives were to determine which milk proteases participate in the proteolysis and to predict which released peptides have bioactivity...
December 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29446000/see-one-do-one-teach-one-a-practical-course-on-methods-in-mammary-gland-biology
#15
EDITORIAL
Martin Jechlinger, Howard Kendrick, Matthew Smalley, Maria dM Vivanco
No abstract text is available yet for this article.
December 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29188494/menin-modulates-mammary-epithelial-cell-numbers-in-bovine-mammary-glands-through-cyclin-d1
#16
Kerong Shi, Xue Liu, Honghui Li, Xueyan Lin, Zhengui Yan, Qiaoqiao Cao, Meng Zhao, Zhongjin Xu, Zhonghua Wang
Menin, the protein encoded by the MEN1 gene, is abundantly expressed in the epithelial cells of mammary glands. Here, we found MEN1/menin expression slowly decreased with advancing lactation but increased by the end of lactation. It happened that the number of bovine mammary epithelial cells decreases since lactation, suggesting a role of menin in the control of mammary epithelial cell growth. Indeed, reduction of menin expression through MEN1-specific siRNA transfection in the bovine mammary epithelial cells caused cell growth arrest in G1/S phase...
December 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29188493/lipid-droplet-fusion-in-mammary-epithelial-cells-is-regulated-by-phosphatidylethanolamine-metabolism
#17
Bat-Chen Cohen, Chen Raz, Avi Shamay, Nurit Argov-Argaman
Mammary epithelial cells (MEC) secrete fat in the form of milk fat globules (MFG) which are found in milk in diverse sizes. MFG originate from intracellular lipid droplets, and the mechanism underlying their size regulation is still elusive. Two main mechanisms have been suggested to control lipid droplet size. The first is a well-documented pathway, which involves regulation of cellular triglyceride content. The second is the fusion pathway, which is less-documented, especially in mammalian cells, and its importance in the regulation of droplet size is still unclear...
December 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28822004/in-vitro-validation-of-the-hippo-pathway-as-a-pharmacological-target-for-canine-mammary-gland-tumors
#18
Samantha Guillemette, Charlène Rico, Philippe Godin, Derek Boerboom, Marilène Paquet
Canine mammary tumors (CMTs) are the most common neoplasms in intact female dogs. Some clinical and molecular similarities between certain CMT subtypes and breast cancer make them a potential model for the study of the human disease. As misregulated Hippo signaling is thought to play an important role in breast cancer development and also occurs in CMTs, we sought to determine if Hippo represents a valid pharmacological target for the treatment of CMTs. Six CMT cell lines were assessed for their expression of the Hippo pathway effectors YAP and TAZ and for their sensitivity to verteporfin, an inhibitor of YAP-mediated transcriptional coactivation...
September 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28707256/monitoring-in-vivo-the-mammary-gland-microstructure-during-morphogenesis-from-lactation-to-post-weaning-using-diffusion-tensor-mri
#19
Noam Nissan, Edna Furman-Haran, Myra Shapiro-Feinberg, Dov Grobgeld, Hadassa Degani
Lactation and the return to the pre-conception state during post-weaning are regulated by hormonal induced processes that modify the microstructure of the mammary gland, leading to changes in the features of the ductal / glandular tissue, the stroma and the fat tissue. These changes create a challenge in the radiological workup of breast disorder during lactation and early post-weaning. Here we present non-invasive MRI protocols designed to record in vivo high spatial resolution, T2-weighted images and diffusion tensor images of the entire mammary gland...
September 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28664511/the-role-of-nitrosamine-nnk-in-breast-cancer-carcinogenesis
#20
REVIEW
Nomundelger Gankhuyag, Kang-Hoon Lee, Je-Yoel Cho
Smoking cigarettes is one of the most concerning issues that leads to tobacco-related cancers and can even result in death. Therefore, these issues should be addressed with a great sense of urgency with low-cost and simple approaches. Over the past several years, the scientific community has attempted to find solutions to overcome this issue. Thus, a large number of excellent studies have been reported in this field, and summarizing these results and providing important roadmaps for future studies is currently of great importance...
September 2017: Journal of Mammary Gland Biology and Neoplasia
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