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Journal of Mammary Gland Biology and Neoplasia

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https://www.readbyqxmd.com/read/28455726/developmental-expression-of-claudins-in-the-mammary-gland
#1
Heidi K Baumgartner, Michael C Rudolph, Palaniappian Ramanathan, Valerie Burns, Patricia Webb, Benjamin G Bitler, Torsten Stein, Ken Kobayashi, Margaret C Neville
Claudins are a large family of membrane proteins whose classic function is to regulate the permeability of tight junctions in epithelia. They are tetraspanins, with four alpha-helices crossing the membrane, two extracellular loops, a short cytoplasmic N-terminus and a longer and more variable C-terminus. The extracellular ends of the helices are known to undergo side-to-side (cis) interactions that allow the formation of claudin polymers in the plane of the membrane. The extracellular loops also engage in head-to-head (trans) interactions thought to mediate the formation of tight junctions...
April 28, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28451789/current-update-of-patient-derived-xenograft-model-for-translational-breast-cancer-research
#2
REVIEW
Tsutomu Kawaguchi, Barbara A Foster, Jessica Young, Kazuaki Takabe
Despite recent advances in the treatment of patients with breast cancer (BrCa), BrCa remains the third leading cause of cancer death for women in the US due to intrinsic or acquired resistance to therapy. Continued understanding of gene expression profiling and genomic sequencing has clarified underlying intratumoral molecular heterogeneity. Recently, the patient-derived xenograft (PDX) models have emerged as a novel tool to address the issues of BrCa genomics and tumor heterogeneity, and to critically transform translational BrCa research in the preclinical setting...
April 27, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28124185/mouse-models-of-breast-cancer-share-amplification-and-deletion-events-with-human-breast-cancer
#3
Jonathan Rennhack, Briana To, Harrison Wermuth, Eran R Andrechek
Breast tumor heterogeneity has been well documented through the use of multiplatform -omic studies in human tumors. However, there is no integrative database to capture the heterogeneity within mouse models of breast cancer. This project identifies genomic copy number alterations (CNAs) in 600 tumors across 27 major mouse models of breast cancer through the application of a predictive algorithm to publicly available gene expression data. It was found that despite the presence of strong oncogenic drivers in most mouse models, CNAs are extremely common but heterogeneous both between models and within models...
March 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28124184/reelin-deficiency-delays-mammary-tumor-growth-and-metastatic-progression
#4
Elvira Khialeeva, Joan W Chou, Denise E Allen, Alec M Chiu, Steven J Bensinger, Ellen M Carpenter
Reelin is a regulator of cell migration in the nervous system, and has other functions in the development of a number of non-neuronal tissues. In addition, alterations in reelin expression levels have been reported in breast, pancreatic, liver, gastric, and other cancers. Reelin is normally expressed in mammary gland stromal cells, but whether stromal reelin contributes to breast cancer progression is unknown. Herein, we used a syngeneic mouse mammary tumor transplantation model to examine the impact of host-derived reelin on breast cancer progression...
March 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27900586/role-of-prolactin-in-promotion-of-immune-cell-migration-into-the-mammary-gland
#5
Riva Dill, Ameae M Walker
Immune cells in the mammary gland play a number of important roles, including protection against infection during lactation and, after passing into milk, modulation of offspring immunity. However, little is known about the mechanism of recruitment of immune cells to the lactating gland in the absence of infection. Given the importance of prolactin to other aspects of lactation, we hypothesized it would also play a role in immune cell recruitment. Prolactin treatment of adult female mice for a period equivalent to pregnancy and the first week of lactation increased immune cell flux through the mammary gland, as reflected in the number of immune cells in mammary gland-draining, but not other lymph nodes...
March 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27889857/accurate-control-of-17%C3%AE-estradiol-long-term-release-increases-reliability-and-reproducibility-of-preclinical-animal-studies
#6
Céline Gérard, Anne Gallez, Charline Dubois, Pierre Drion, Philippe Delahaut, Etienne Quertemont, Agnès Noël, Christel Pequeux
Estrogens are the subject of intensive researches aiming to elucidate their mechanism of action on the various tissues they target and especially on mammary gland and breast cancer. The use of ready-to-use slow releasing devices to administer steroids, especially estrogens, to small experimental animals remains the method of choice in terms of animal well-being and of safety for both the researcher and the animal. In this study, we evaluated and compared, in vitro and in vivo, the release kinetic of estradiol (E2) over sixty days from two different slow-releasing systems: the matrix pellet (MP) and the reservoir implant (RI)...
March 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28243823/role-of-phospholipid-flux-during-milk-secretion-in-the-mammary-gland
#7
REVIEW
Michał Smoczyński
Lipids are a complex group of chemical compounds that are a significant component of the human diet and are one of the main constituents of milk. In mammals, lipids are produced in the milk-secreting cells in the form of milk fat globules. The chemical properties of these compounds necessitate developing separate processes for effective management of non-polar substances in the polar environment of the cell, not only during their biosynthesis and accumulation in the cell interior and secretion of intracytoplasmic lipid droplets outside the cell, but also during digestion in the offspring...
February 27, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28168376/the-terminal-end-bud-the-little-engine-that-could
#8
REVIEW
Ingrid S Paine, Michael T Lewis
The mammary gland is one of the most regenerative organs in the body, with the majority of development occurring postnatally and in the adult mammal. Formation of the ductal tree is orchestrated by a specialized structure called the terminal end bud (TEB). The TEB is responsible for the production of mature cell types leading to the elongation of the subtending duct. The TEB is also the regulatory control point for basement membrane deposition, branching, angiogenesis, and pattern formation. While the hormonal control of TEB growth is well characterized, the local regulatory factors are less well understood...
February 6, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28144768/variation-of-human-milk-glucocorticoids-over-24%C3%A2-hour-period
#9
Shikha Pundir, Clare R Wall, Cameron J Mitchell, Eric B Thorstensen, Ching T Lai, Donna T Geddes, David Cameron-Smith
Human milk (HM) contains a complex array of hormones, including members of the glucocorticoid family. The predominant glucocorticoids, cortisol and cortisone may influence the growth and behaviour of the breastfed infant. However, little is understood of the factors regulating the levels of these hormones within HM. The aim of the study was to examine HM cortisol and cortisone concentration, measured in samples collected at each feed during a 24 hour period. Twenty three exclusively breastfeeding mothers collected milk, prior to and after each breastfeeding session over 24 hour period at 3...
January 31, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28078601/inhibition-of-epithelial-mesenchymal-transition-and-metastasis-by-combined-tgfbeta-knockdown-and-metformin-treatment-in-a-canine-mammary-cancer-xenograft-model
#10
Camila Leonel, Thaiz Ferraz Borin, Lívia de Carvalho Ferreira, Marina Gobbe Moschetta, Marcio Chaim Bajgelman, Alicia M Viloria-Petit, Debora Aparecida Pires de Campos Zuccari
Epithelial mesenchymal transition (EMT) is a process by which epithelial cells acquire mesenchymal properties, generating metastases. Transforming growth factor beta (TGF-β) is associated with this malignancy by having the ability to induce EMT. Metformin, has been shown to inhibit EMT in breast cancer cells. Based on this evidence we hypothesize that treatment with metformin and the silencing of TGF-β, inhibits the EMT in cancer cells. Canine metastatic mammary tumor cell line CF41 was stably transduced with a shRNA-lentivirus, reducing expression level of TGF-β1...
January 11, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28074314/a-novel-effect-of-%C3%AE-adrenergic-receptor-on-mammary-branching-morphogenesis-and-its-possible-implications-in-breast-cancer
#11
Lucía Gargiulo, María May, Ezequiel M Rivero, Sabrina Copsel, Caroline Lamb, John Lydon, Carlos Davio, Claudia Lanari, Isabel A Lüthy, Ariana Bruzzone
Understanding the mechanisms that govern normal mammary gland development is crucial to the comprehension of breast cancer etiology. β-adrenergic receptors (β-AR) are targets of endogenous catecholamines such as epinephrine that have gained importance in the context of cancer biology. Differences in β2-AR expression levels may be responsible for the effects of epinephrine on tumor vs non-tumorigenic breast cell lines, the latter expressing higher levels of β2-AR. To study regulation of the breast cell phenotype by β2-AR, we over-expressed β2-AR in MCF-7 breast cancer cells and knocked-down the receptor in non-tumorigenic MCF-10A breast cells...
January 11, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27889858/the-pursuit-of-truth-in-the-company-of-friends-in-memorium-charles-w-daniel
#12
EDITORIAL
Gary B Silberstein, Michael T Lewis
No abstract text is available yet for this article.
December 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27815674/epithelial-plasticity-during-human-breast-morphogenesis-and-cancer-progression
#13
REVIEW
Saevar Ingthorsson, Eirikur Briem, Jon Thor Bergthorsson, Thorarinn Gudjonsson
Understanding the complex events leading to formation of an epithelial-based organ such as the breast requires a detailed insight into the crosstalk between epithelial and stromal compartments. These interactions occur both through heterotypic cellular interactions and between cells and matrix components. While in vivo models may partially capture these complex interactions, there is a need for in- vitro models to study these events. In this review we discuss cell-cell interactions in breast development focusing on the stem cell niche and branching morphogenesis...
December 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27815673/erratum-to-patient-derived-mammosphere-and-xenograft-tumour-initiation-correlates-with-progression-to-metastasis
#14
Rachel Eyre, Denis G Alférez, Kath Spence, Mohamed Kamal, Frances L Shaw, Bruno M Simões, Angélica Santiago-Gómez, Aida Sarmiento-Castro, Maria Bramley, Mohammed Absar, Zahida Saad, Sumohan Chatterjee, Cliona Kirwan, Ashu Gandhi, Anne C Armstrong, Andrew M Wardley, Ciara S O'Brien, Gillian Farnie, Sacha J Howell, Robert B Clarke
No abstract text is available yet for this article.
December 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27796616/human-milk-fatty-acid-composition-comparison-of-novel-dried-milk-spot-versus-standard-liquid-extraction-methods
#15
Michael C Rudolph, Bridget E Young, Kristina Harris Jackson, Nancy F Krebs, William S Harris, Paul S MacLean
Accurate assessment of the long chain polyunsaturated fatty acid (LC-PUFA) content of human milk (HM) provides a powerful means to evaluate the FA nutrient status of breastfed infants. The conventional standard for FA composition analysis of HM is liquid extraction, trans-methylation, and analyte detection resolved by gas chromatography. This standard approach requires fresh or frozen samples, storage in deep freeze, organic solvents, and specialized equipment in processing and analysis. Further, HM collection is often impractical for many studies in the free living environment, particularly for studies in developing countries...
December 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27744517/the-many-axes-of-deer-lactation
#16
Francisco Ceacero, Andrés J García, Tomás Landete-Castillejos, Martina Komárková, Francisco Hidalgo, Martina P Serrano, Laureano Gallego
In undomesticated animals information about the production and composition of milk over time is still scarce. In general, for most mammals it is known that milk composition changes across lactation, is different for male and female offspring, and even that marsupials, such as kangaroos, can simultaneously produce milk of different compositions for young of different ages. Such parallel milk production of differing compositions has not yet been studied in single-offspring placental mammals, but may help to explain behavioural processes like allosuckling (feeding the young of other adults) and lateralized suckling preferences...
December 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27714576/comparison-of-the-adipose-and-luminal-mammary-gland-compartment-as-orthotopic-inoculation-sites-in-a-4t1-based-immunocompetent-preclinical-model-for-triple-negative-breast-cancer
#17
Jonas Steenbrugge, Koen Breyne, Sofie Denies, Melissa Dekimpe, Kristel Demeyere, Olivier De Wever, Peter Vermeulen, Steven Van Laere, Niek N Sanders, Evelyne Meyer
Breast tumorigenesis is classically studied in mice by inoculating tumor cells in the fat pad, the adipose compartment of the mammary gland. Alternatively, the mammary ducts, which constitute the luminal mammary gland compartment, also provide a suitable inoculation site to induce breast cancer in murine models. The microenvironments in these compartments influence tumor cell progression, yet this effect has not been investigated in an immunocompetent context. Here, we compared both mammary gland compartments as distinct inoculation sites, taking into account the immunological aspect by inoculating 4T1 tumor cells in immunocompetent mice...
December 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27680982/patient-derived-mammosphere-and-xenograft-tumour-initiation-correlates-with-progression-to-metastasis
#18
Rachel Eyre, Denis G Alférez, Kath Spence, Mohamed Kamal, Frances L Shaw, Bruno M Simões, Angélica Santiago-Gómez, Aida Sarmiento-Castro, Maria Bramley, Mohammed Absar, Zahida Saad, Sumohan Chatterjee, Cliona Kirwan, Ashu Gandhi, Anne C Armstrong, Andrew M Wardley, Ciara S O'Brien, Gillian Farnie, Sacha J Howell, Robert B Clarke
Breast cancer specific mortality results from tumour cell dissemination and metastatic colonisation. Identification of the cells and processes responsible for metastasis will enable better prevention and control of metastatic disease, thus reducing relapse and mortality. To better understand these processes, we prospectively collected 307 patient-derived breast cancer samples (n = 195 early breast cancers (EBC) and n = 112 metastatic samples (MBC)). We assessed colony-forming activity in vitro by growing isolated cells in both primary (formation) and secondary (self-renewal) mammosphere culture, and tumour initiating activity in vivo through subcutaneous transplantation of fragments or cells into mice...
December 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27518775/generation-of-multicellular-breast-cancer-tumor-spheroids-comparison-of-different-protocols
#19
REVIEW
Karolin Froehlich, Jan-Dirk Haeger, Julia Heger, Jana Pastuschek, Stella Mary Photini, Yan Yan, Amelie Lupp, Christiane Pfarrer, Ralf Mrowka, Ekkehard Schleußner, Udo R Markert, André Schmidt
Multicellular tumor spheroids are widely used models in tumor research. Because of their three dimensional organization they can simulate avascular tumor areas comprising proliferative and necrotic cells. Nonetheless, protocols for spheroid generation are still inconsistent. Therefore, in this study the breast cancer cell lines MCF-7, MDA-MB-231 and SK-BR-3 have been used to compare different spheroid generation models including hanging drop, liquid overlay and suspension culture techniques, each under several conditions...
December 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27411687/p120-catenin-is-critical-for-the-development-of-invasive-lobular-carcinoma-in-mice
#20
Milou Tenhagen, Sjoerd Klarenbeek, Tanya M Braumuller, Ilse Hofmann, Petra van der Groep, Natalie Ter Hoeve, Elsken van der Wall, Jos Jonkers, Patrick W B Derksen
Loss of E-cadherin expression is causal to the development of invasive lobular breast carcinoma (ILC). E-cadherin loss leads to dismantling of the adherens junction and subsequent translocation of p120-catenin (p120) to the cytosol and nucleus. Although p120 is critical for the metastatic potential of ILC through the regulation of Rock-dependent anoikis resistance, it remains unknown whether p120 also contributes to ILC development. Using genetically engineered mouse models with mammary gland-specific inactivation of E-cadherin, p120 and p53, we demonstrate that ILC formation induced by E-cadherin and p53 loss is severely impaired upon concomitant inactivation of p120...
December 2016: Journal of Mammary Gland Biology and Neoplasia
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